medsci-skills 4.1.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/LICENSE +50 -0
- package/README.md +602 -0
- package/README_FIRST.md +27 -0
- package/bin/medsci-skills.js +159 -0
- package/installers/install-macos.command +19 -0
- package/installers/install-windows.cmd +26 -0
- package/installers/install-windows.ps1 +17 -0
- package/installers/install.py +218 -0
- package/metadata/skills_catalog.json +452 -0
- package/package.json +48 -0
- package/skills/academic-aio/SKILL.md +408 -0
- package/skills/academic-aio/references/case_studies/kjr_mllm_2025.md +82 -0
- package/skills/academic-aio/references/checklists/AIO_GENERAL.md +354 -0
- package/skills/academic-aio/references/journal_summarybox_templates.yaml +126 -0
- package/skills/academic-aio/references/oac_funding_checklist.yaml +129 -0
- package/skills/academic-aio/references/reporting_guideline_mapping.md +39 -0
- package/skills/academic-aio/references/schema_markup_templates/CodeRepository.jsonld +32 -0
- package/skills/academic-aio/references/schema_markup_templates/Dataset.jsonld +36 -0
- package/skills/academic-aio/references/schema_markup_templates/Person.jsonld +30 -0
- package/skills/academic-aio/references/schema_markup_templates/README.md +43 -0
- package/skills/academic-aio/references/schema_markup_templates/ScholarlyArticle.jsonld +55 -0
- package/skills/academic-aio/scripts/batch_metadata_audit.py +169 -0
- package/skills/academic-aio/scripts/validate_schema.py +118 -0
- package/skills/academic-aio/skill.yml +36 -0
- package/skills/academic-aio/templates/aio_audit_checklist.md.j2 +108 -0
- package/skills/add-journal/SKILL.md +482 -0
- package/skills/add-journal/skill.yml +33 -0
- package/skills/analyze-stats/SKILL.md +598 -0
- package/skills/analyze-stats/references/analysis_guides/missing_data.md +109 -0
- package/skills/analyze-stats/references/analysis_guides/nhis_icd10_mapping.md +247 -0
- package/skills/analyze-stats/references/analysis_guides/propensity_score.md +132 -0
- package/skills/analyze-stats/references/analysis_guides/regression.md +115 -0
- package/skills/analyze-stats/references/analysis_guides/repeated_measures.md +160 -0
- package/skills/analyze-stats/references/analysis_guides/survey_weighted.md +366 -0
- package/skills/analyze-stats/references/analysis_guides/test_selection.md +86 -0
- package/skills/analyze-stats/references/style/figure_style.mplstyle +69 -0
- package/skills/analyze-stats/references/style/theme_publication.R +147 -0
- package/skills/analyze-stats/references/table-standards/journal-profiles/ajr.yaml +51 -0
- package/skills/analyze-stats/references/table-standards/journal-profiles/european_radiology.yaml +55 -0
- package/skills/analyze-stats/references/table-standards/journal-profiles/jama.yaml +66 -0
- package/skills/analyze-stats/references/table-standards/journal-profiles/lancet.yaml +57 -0
- package/skills/analyze-stats/references/table-standards/journal-profiles/nejm.yaml +51 -0
- package/skills/analyze-stats/references/table-standards/journal-profiles/radiology.yaml +66 -0
- package/skills/analyze-stats/references/table-standards/table-standards.md +287 -0
- package/skills/analyze-stats/references/table-standards/table-types/diagnostic_accuracy.md +36 -0
- package/skills/analyze-stats/references/table-standards/table-types/meta_analysis.md +58 -0
- package/skills/analyze-stats/references/table-standards/table-types/model_comparison.md +36 -0
- package/skills/analyze-stats/references/table-standards/table-types/regression_results.md +50 -0
- package/skills/analyze-stats/references/table-standards/table-types/table1_demographics.md +51 -0
- package/skills/analyze-stats/references/table-standards/tool-comparison.md +79 -0
- package/skills/analyze-stats/references/templates/agreement_analysis.py +436 -0
- package/skills/analyze-stats/references/templates/dca_plot.R +237 -0
- package/skills/analyze-stats/references/templates/diagnostic_accuracy.py +401 -0
- package/skills/analyze-stats/references/templates/dta_meta_analysis.R +384 -0
- package/skills/analyze-stats/references/templates/forest_plot.py +412 -0
- package/skills/analyze-stats/references/templates/likert_summary.py +356 -0
- package/skills/analyze-stats/references/templates/meta_analysis.R +365 -0
- package/skills/analyze-stats/references/templates/propensity_score.py +478 -0
- package/skills/analyze-stats/references/templates/regression.py +425 -0
- package/skills/analyze-stats/references/templates/repeated_measures.py +434 -0
- package/skills/analyze-stats/references/templates/sample_size.R +382 -0
- package/skills/analyze-stats/references/templates/survey_weighted_analysis.py +411 -0
- package/skills/analyze-stats/references/templates/survival_analysis.py +325 -0
- package/skills/analyze-stats/references/templates/table1_demographics.py +287 -0
- package/skills/analyze-stats/scripts/check_generated_code.py +335 -0
- package/skills/analyze-stats/skill.yml +38 -0
- package/skills/analyze-stats/tests/fixtures/gen_bad.R +16 -0
- package/skills/analyze-stats/tests/fixtures/gen_bad.py +24 -0
- package/skills/analyze-stats/tests/fixtures/gen_clean.py +21 -0
- package/skills/analyze-stats/tests/test_generated_code.sh +59 -0
- package/skills/analyze-stats/tests/test_survival_template.sh +53 -0
- package/skills/author-strategy/SKILL.md +117 -0
- package/skills/author-strategy/analyze_patterns.py +303 -0
- package/skills/author-strategy/fetch_pubmed.py +374 -0
- package/skills/author-strategy/skill.yml +34 -0
- package/skills/batch-cohort/SKILL.md +223 -0
- package/skills/batch-cohort/references/base_template_knhanes.R +210 -0
- package/skills/batch-cohort/references/batch_template_generator.R +222 -0
- package/skills/batch-cohort/references/variable_coding_registry.md +136 -0
- package/skills/batch-cohort/skill.yml +35 -0
- package/skills/calc-sample-size/SKILL.md +491 -0
- package/skills/calc-sample-size/references/formulas.md +655 -0
- package/skills/calc-sample-size/references/observational_cohort.md +49 -0
- package/skills/calc-sample-size/skill.yml +51 -0
- package/skills/check-reporting/SKILL.md +534 -0
- package/skills/check-reporting/references/LICENSES.md +41 -0
- package/skills/check-reporting/references/checklists/AMSTAR2.md +54 -0
- package/skills/check-reporting/references/checklists/ARRIVE_2.md +234 -0
- package/skills/check-reporting/references/checklists/CARE.md +102 -0
- package/skills/check-reporting/references/checklists/CLAIM_2024.md +128 -0
- package/skills/check-reporting/references/checklists/CLEAR.md +113 -0
- package/skills/check-reporting/references/checklists/CONSORT.md +86 -0
- package/skills/check-reporting/references/checklists/COSMIN_RoB.md +136 -0
- package/skills/check-reporting/references/checklists/GRRAS.md +61 -0
- package/skills/check-reporting/references/checklists/MI_CLEAR_LLM.md +167 -0
- package/skills/check-reporting/references/checklists/MOOSE.md +85 -0
- package/skills/check-reporting/references/checklists/NOS.md +88 -0
- package/skills/check-reporting/references/checklists/PRISMA_2020.md +135 -0
- package/skills/check-reporting/references/checklists/PRISMA_DTA.md +36 -0
- package/skills/check-reporting/references/checklists/PRISMA_P.md +56 -0
- package/skills/check-reporting/references/checklists/PROBAST.md +75 -0
- package/skills/check-reporting/references/checklists/PROBAST_AI.md +130 -0
- package/skills/check-reporting/references/checklists/QUADAS2.md +77 -0
- package/skills/check-reporting/references/checklists/QUADAS_C.md +131 -0
- package/skills/check-reporting/references/checklists/ROBINS_E.md +179 -0
- package/skills/check-reporting/references/checklists/ROBINS_I.md +87 -0
- package/skills/check-reporting/references/checklists/ROBIS.md +114 -0
- package/skills/check-reporting/references/checklists/ROB_ME.md +126 -0
- package/skills/check-reporting/references/checklists/RoB2.md +79 -0
- package/skills/check-reporting/references/checklists/RoB_NMA.md +96 -0
- package/skills/check-reporting/references/checklists/SPIRIT.md +112 -0
- package/skills/check-reporting/references/checklists/SQUIRE_2.md +68 -0
- package/skills/check-reporting/references/checklists/STARD.md +129 -0
- package/skills/check-reporting/references/checklists/STARD_AI.md +211 -0
- package/skills/check-reporting/references/checklists/STROBE.md +80 -0
- package/skills/check-reporting/references/checklists/SWiM.md +33 -0
- package/skills/check-reporting/references/checklists/TRIPOD.md +157 -0
- package/skills/check-reporting/references/checklists/TRIPOD_AI.md +140 -0
- package/skills/check-reporting/references/step4c_registration_timing.md +93 -0
- package/skills/check-reporting/references/step4d_prisma_figure_audit.md +137 -0
- package/skills/check-reporting/scripts/check_checklist_exists.py +183 -0
- package/skills/check-reporting/scripts/check_checklist_version.py +168 -0
- package/skills/check-reporting/scripts/check_framework_naming.py +206 -0
- package/skills/check-reporting/scripts/check_prisma_figure.py +209 -0
- package/skills/check-reporting/scripts/prisma_cascade_check.py +274 -0
- package/skills/check-reporting/skill.yml +41 -0
- package/skills/check-reporting/tests/fixtures/framework_bad.md +8 -0
- package/skills/check-reporting/tests/fixtures/framework_clean.md +7 -0
- package/skills/check-reporting/tests/test_checklist_fail_fast.sh +77 -0
- package/skills/check-reporting/tests/test_checklist_version.sh +72 -0
- package/skills/check-reporting/tests/test_framework_naming.sh +45 -0
- package/skills/check-reporting/tests/test_prisma_cascade.sh +104 -0
- package/skills/clean-data/SKILL.md +180 -0
- package/skills/clean-data/references/cleaning_patterns.md +299 -0
- package/skills/clean-data/references/profiling_template.py +304 -0
- package/skills/clean-data/scripts/check_structural_zero.py +174 -0
- package/skills/clean-data/skill.yml +35 -0
- package/skills/clean-data/tests/fixtures/smoking.csv +8 -0
- package/skills/clean-data/tests/test_structural_zero.sh +49 -0
- package/skills/cross-national/SKILL.md +264 -0
- package/skills/cross-national/skill.yml +37 -0
- package/skills/define-variables/SKILL.md +146 -0
- package/skills/define-variables/references/common_definitions.md +190 -0
- package/skills/define-variables/skill.yml +34 -0
- package/skills/define-variables/templates/variable_operationalization.md +64 -0
- package/skills/deidentify/SKILL.md +203 -0
- package/skills/deidentify/deidentify.py +1224 -0
- package/skills/deidentify/locales/_template.json +45 -0
- package/skills/deidentify/locales/au.json +43 -0
- package/skills/deidentify/locales/ca.json +44 -0
- package/skills/deidentify/locales/cn.json +47 -0
- package/skills/deidentify/locales/de.json +48 -0
- package/skills/deidentify/locales/fr.json +48 -0
- package/skills/deidentify/locales/in.json +48 -0
- package/skills/deidentify/locales/jp.json +48 -0
- package/skills/deidentify/locales/kr.json +48 -0
- package/skills/deidentify/locales/uk.json +45 -0
- package/skills/deidentify/locales/us.json +43 -0
- package/skills/deidentify/references/date_shift_guide.md +82 -0
- package/skills/deidentify/references/hipaa_18_identifiers.md +48 -0
- package/skills/deidentify/references/korean_phi_patterns.md +135 -0
- package/skills/deidentify/skill.yml +43 -0
- package/skills/deidentify/tests/README.md +26 -0
- package/skills/deidentify/tests/test_clean.csv +16 -0
- package/skills/deidentify/tests/test_edge_cases.csv +11 -0
- package/skills/deidentify/tests/test_phi_korean.csv +11 -0
- package/skills/design-ai-benchmarking/SKILL.md +214 -0
- package/skills/design-ai-benchmarking/references/benchmark_export_schema.json +69 -0
- package/skills/design-ai-benchmarking/references/elicitation_rubric_template.md +37 -0
- package/skills/design-ai-benchmarking/skill.yml +38 -0
- package/skills/design-study/SKILL.md +298 -0
- package/skills/design-study/skill.yml +33 -0
- package/skills/fill-icmje-coi/SKILL.md +216 -0
- package/skills/fill-icmje-coi/scripts/fill_icmje_coi.py +140 -0
- package/skills/fill-icmje-coi/skill.yml +35 -0
- package/skills/fill-icmje-coi/templates/icmje_coi_seed_synthetic.docx +0 -0
- package/skills/fill-protocol/SKILL.md +248 -0
- package/skills/fill-protocol/examples/example_irb_template.yaml +53 -0
- package/skills/fill-protocol/references/best_practices.md +121 -0
- package/skills/fill-protocol/scripts/doc_to_docx.py +111 -0
- package/skills/fill-protocol/scripts/fill_form.py +611 -0
- package/skills/fill-protocol/scripts/inspect_template.py +61 -0
- package/skills/fill-protocol/setup.sh +162 -0
- package/skills/fill-protocol/skill.yml +37 -0
- package/skills/find-cohort-gap/SKILL.md +309 -0
- package/skills/find-cohort-gap/references/cohort_profile_template.md +93 -0
- package/skills/find-cohort-gap/references/onepager_template.md +84 -0
- package/skills/find-cohort-gap/references/pattern_scoring_rubric.md +169 -0
- package/skills/find-cohort-gap/references/saturation_query_templates.md +143 -0
- package/skills/find-cohort-gap/skill.yml +35 -0
- package/skills/find-journal/POLICY.md +87 -0
- package/skills/find-journal/SKILL.md +340 -0
- package/skills/find-journal/references/journal_profiles/AJNR.md +29 -0
- package/skills/find-journal/references/journal_profiles/AJR.md +30 -0
- package/skills/find-journal/references/journal_profiles/Abdominal_Radiology.md +30 -0
- package/skills/find-journal/references/journal_profiles/Academic_Radiology.md +30 -0
- package/skills/find-journal/references/journal_profiles/Annals_of_Internal_Medicine.md +33 -0
- package/skills/find-journal/references/journal_profiles/Artificial_Intelligence_in_Medicine.md +28 -0
- package/skills/find-journal/references/journal_profiles/BMC_Medicine.md +31 -0
- package/skills/find-journal/references/journal_profiles/British_Journal_of_Radiology.md +39 -0
- package/skills/find-journal/references/journal_profiles/CVIR.md +30 -0
- package/skills/find-journal/references/journal_profiles/Chest.md +39 -0
- package/skills/find-journal/references/journal_profiles/Clinical_Radiology.md +30 -0
- package/skills/find-journal/references/journal_profiles/Clinical_and_Molecular_Hepatology.md +32 -0
- package/skills/find-journal/references/journal_profiles/Diabetes_Metabolism_Journal.md +36 -0
- package/skills/find-journal/references/journal_profiles/Diagnostic_and_Interventional_Radiology.md +32 -0
- package/skills/find-journal/references/journal_profiles/Endocrinology_and_Metabolism.md +37 -0
- package/skills/find-journal/references/journal_profiles/European_Journal_of_Preventive_Cardiology.md +39 -0
- package/skills/find-journal/references/journal_profiles/European_Radiology.md +29 -0
- package/skills/find-journal/references/journal_profiles/Hepatology_Communications.md +40 -0
- package/skills/find-journal/references/journal_profiles/Hepatology_International.md +37 -0
- package/skills/find-journal/references/journal_profiles/IEEE_JBHI.md +28 -0
- package/skills/find-journal/references/journal_profiles/IEEE_TMI.md +28 -0
- package/skills/find-journal/references/journal_profiles/INSI.md +29 -0
- package/skills/find-journal/references/journal_profiles/Investigative_Radiology.md +25 -0
- package/skills/find-journal/references/journal_profiles/JACC_Advances.md +41 -0
- package/skills/find-journal/references/journal_profiles/JACC_Asia.md +30 -0
- package/skills/find-journal/references/journal_profiles/JACR.md +28 -0
- package/skills/find-journal/references/journal_profiles/JAMA.md +40 -0
- package/skills/find-journal/references/journal_profiles/JAMA_Network_Open.md +30 -0
- package/skills/find-journal/references/journal_profiles/JCSM.md +39 -0
- package/skills/find-journal/references/journal_profiles/JKMS.md +32 -0
- package/skills/find-journal/references/journal_profiles/JMIR.md +29 -0
- package/skills/find-journal/references/journal_profiles/JMIR_Medical_Education.md +29 -0
- package/skills/find-journal/references/journal_profiles/JNIS.md +35 -0
- package/skills/find-journal/references/journal_profiles/JVIR.md +31 -0
- package/skills/find-journal/references/journal_profiles/Journal_of_Biomedical_Informatics.md +29 -0
- package/skills/find-journal/references/journal_profiles/Journal_of_Clinical_Endocrinology_and_Metabolism.md +40 -0
- package/skills/find-journal/references/journal_profiles/Journal_of_Magnetic_Resonance_Imaging.md +30 -0
- package/skills/find-journal/references/journal_profiles/Journal_of_Nuclear_Medicine.md +31 -0
- package/skills/find-journal/references/journal_profiles/Journal_of_Stroke.md +32 -0
- package/skills/find-journal/references/journal_profiles/KJR.md +38 -0
- package/skills/find-journal/references/journal_profiles/Korean_Circulation_Journal.md +38 -0
- package/skills/find-journal/references/journal_profiles/Korean_Journal_of_Internal_Medicine.md +36 -0
- package/skills/find-journal/references/journal_profiles/Lancet_Diabetes_and_Endocrinology.md +40 -0
- package/skills/find-journal/references/journal_profiles/Lancet_Gastroenterology_and_Hepatology.md +49 -0
- package/skills/find-journal/references/journal_profiles/Lancet_Infectious_Diseases.md +38 -0
- package/skills/find-journal/references/journal_profiles/Lancet_Neurology.md +39 -0
- package/skills/find-journal/references/journal_profiles/Lancet_Oncology.md +40 -0
- package/skills/find-journal/references/journal_profiles/Lancet_Psychiatry.md +38 -0
- package/skills/find-journal/references/journal_profiles/Lancet_Public_Health.md +30 -0
- package/skills/find-journal/references/journal_profiles/Lancet_Respiratory_Medicine.md +39 -0
- package/skills/find-journal/references/journal_profiles/Liver_International.md +33 -0
- package/skills/find-journal/references/journal_profiles/Medical_Image_Analysis.md +28 -0
- package/skills/find-journal/references/journal_profiles/NEJM.md +33 -0
- package/skills/find-journal/references/journal_profiles/Nature_Machine_Intelligence.md +31 -0
- package/skills/find-journal/references/journal_profiles/Nature_Medicine.md +39 -0
- package/skills/find-journal/references/journal_profiles/Neuroradiology.md +31 -0
- package/skills/find-journal/references/journal_profiles/Nutrition_Metabolism_and_Cardiovascular_Diseases.md +39 -0
- package/skills/find-journal/references/journal_profiles/PLOS_Medicine.md +32 -0
- package/skills/find-journal/references/journal_profiles/RYAI.md +28 -0
- package/skills/find-journal/references/journal_profiles/Radiology.md +29 -0
- package/skills/find-journal/references/journal_profiles/Skeletal_Radiology.md +31 -0
- package/skills/find-journal/references/journal_profiles/Stroke.md +37 -0
- package/skills/find-journal/references/journal_profiles/The_BMJ.md +31 -0
- package/skills/find-journal/references/journal_profiles/The_Lancet.md +31 -0
- package/skills/find-journal/references/journal_profiles/The_Lancet_Digital_Health.md +29 -0
- package/skills/find-journal/references/journal_profiles/World_Journal_of_Hepatology.md +53 -0
- package/skills/find-journal/references/journal_profiles/npj_Digital_Medicine.md +29 -0
- package/skills/find-journal/skill.yml +34 -0
- package/skills/fulltext-retrieval/SKILL.md +174 -0
- package/skills/fulltext-retrieval/fetch_oa.py +433 -0
- package/skills/fulltext-retrieval/pdf_to_md.py +160 -0
- package/skills/fulltext-retrieval/skill.yml +41 -0
- package/skills/generate-codebook/SKILL.md +155 -0
- package/skills/generate-codebook/references/codebook_schema.md +76 -0
- package/skills/generate-codebook/scripts/generate_codebook.py +278 -0
- package/skills/generate-codebook/skill.yml +35 -0
- package/skills/generate-codebook/tests/test_generate_codebook.sh +76 -0
- package/skills/grant-builder/SKILL.md +251 -0
- package/skills/grant-builder/skill.yml +34 -0
- package/skills/humanize/SKILL.md +251 -0
- package/skills/humanize/references/ai_patterns.md +571 -0
- package/skills/humanize/skill.yml +33 -0
- package/skills/intake-project/SKILL.md +264 -0
- package/skills/intake-project/skill.yml +34 -0
- package/skills/lit-sync/SKILL.md +448 -0
- package/skills/lit-sync/references/locale/ko/note_templates.md +110 -0
- package/skills/lit-sync/skill.yml +52 -0
- package/skills/lit-sync/tests/test_poll_logic.sh +92 -0
- package/skills/ma-scout/SKILL.md +640 -0
- package/skills/ma-scout/references/project_readme_template.md +95 -0
- package/skills/ma-scout/references/project_readme_template_ko.md +82 -0
- package/skills/ma-scout/skill.yml +33 -0
- package/skills/make-figures/SKILL.md +957 -0
- package/skills/make-figures/references/critic_rubrics/data_plot.md +166 -0
- package/skills/make-figures/references/critic_rubrics/flow_diagram.md +169 -0
- package/skills/make-figures/references/design_principles.md +181 -0
- package/skills/make-figures/references/exemplar_diagrams/README.md +65 -0
- package/skills/make-figures/references/exemplar_diagrams/consort/README.md +15 -0
- package/skills/make-figures/references/exemplar_diagrams/consort/template_input.yaml +37 -0
- package/skills/make-figures/references/exemplar_diagrams/consort/template_output.pdf +0 -0
- package/skills/make-figures/references/exemplar_diagrams/consort/template_output.png +0 -0
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"""
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survival_analysis.py — Publication-ready Survival Analysis
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===========================================================
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Kaplan-Meier curves, log-rank test, Cox proportional hazards model.
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Input CSV columns:
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time : float — Time to event or censoring (in days/months/years)
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event : int — Event indicator (1 = event occurred, 0 = censored)
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group : str — Group variable for KM comparison (optional)
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[covariates]: float/int — Covariates for Cox model
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Outputs:
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- KM plot with at-risk table (PNG/PDF, 300 DPI)
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- Cox model results table (CSV)
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- Console: complete results summary
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Usage:
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python survival_analysis.py --input data.csv \
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--time time_months --event event \
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--group treatment_group \
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--covariates age sex bmi comorbidity \
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--time-unit "Months" \
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--output survival_analysis
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Dependencies:
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pip install lifelines pandas numpy matplotlib scipy
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"""
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import argparse
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import sys
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from datetime import datetime
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import numpy as np
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import pandas as pd
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import matplotlib.pyplot as plt
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import matplotlib.gridspec as gridspec
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try:
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from lifelines import KaplanMeierFitter, CoxPHFitter
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from lifelines.statistics import logrank_test, multivariate_logrank_test
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from lifelines.utils import restricted_mean_survival_time, median_survival_times
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LIFELINES_AVAILABLE = True
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except ImportError:
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LIFELINES_AVAILABLE = False
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print("ERROR: lifelines not installed. Install with: pip install lifelines")
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sys.exit(1)
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# ── Reproducibility ───────────────────────────────────────────────────────────
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SCRIPT_VERSION = "1.0.0"
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SEED = 42
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np.random.seed(SEED)
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def _fmt_time(x):
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"""Format a survival time; 'NR' (not reached) for inf/NaN."""
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if x is None or not np.isfinite(x):
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return "NR"
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return f"{x:.1f}"
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def median_with_ci(kmf, unit):
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"""Median survival with its 95% CI from a fitted KaplanMeierFitter.
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A median point estimate reported without its CI is incomplete (analyze-stats
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Survival reporting rule). Returns 'NR' when the median is not reached.
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"""
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med = kmf.median_survival_time_
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try:
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ci = median_survival_times(kmf.confidence_interval_)
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lo, hi = ci.iloc[0, 0], ci.iloc[0, 1]
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except Exception:
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lo = hi = float("nan")
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return f"{_fmt_time(med)} (95% CI {_fmt_time(lo)}–{_fmt_time(hi)}) {unit}"
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print(f"survival_analysis.py v{SCRIPT_VERSION} | {datetime.now().strftime('%Y-%m-%d')}")
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# ── Style ─────────────────────────────────────────────────────────────────────
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plt.rcParams.update({
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"font.family": "Arial",
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"font.size": 9,
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"axes.labelsize": 9,
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"xtick.labelsize": 8,
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"ytick.labelsize": 8,
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})
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WONG_COLORS = ["#0072B2", "#D55E00", "#009E73", "#E69F00", "#CC79A7", "#56B4E9"]
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LINE_STYLES = ["-", "--", "-.", ":", (0, (3, 1, 1, 1))]
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def load_data(filepath, time_col, event_col):
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df = pd.read_csv(filepath)
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for col in [time_col, event_col]:
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if col not in df.columns:
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raise ValueError(f"Column '{col}' not found in {filepath}")
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df = df.dropna(subset=[time_col, event_col])
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return df
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def km_analysis(df, time_col, event_col, group_col=None,
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time_unit="Months", output_path="survival"):
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"""Kaplan-Meier analysis with at-risk table."""
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fig = plt.figure(figsize=(7.0, 5.0))
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if group_col and group_col in df.columns:
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groups = sorted(df[group_col].dropna().unique())
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n_groups = len(groups)
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gs = gridspec.GridSpec(2, 1, height_ratios=[3.5, 1.5], hspace=0.05)
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else:
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groups = None
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n_groups = 1
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gs = gridspec.GridSpec(2, 1, height_ratios=[3.5, 1.5], hspace=0.05)
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ax_km = fig.add_subplot(gs[0])
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ax_risk = fig.add_subplot(gs[1])
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fitters = {}
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if groups:
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for i, g in enumerate(groups):
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mask = df[group_col] == g
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d = df[mask]
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kmf = KaplanMeierFitter()
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kmf.fit(d[time_col], d[event_col], label=str(g))
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fitters[g] = kmf
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kmf.plot_survival_function(
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ax=ax_km,
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color=WONG_COLORS[i % len(WONG_COLORS)],
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linestyle=LINE_STYLES[i % len(LINE_STYLES)],
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linewidth=1.5,
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ci_show=True,
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ci_alpha=0.15,
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)
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# Median survival with 95% CI
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print(f" {g}: Median survival = {median_with_ci(kmf, time_unit)}")
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# Log-rank test
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if n_groups == 2:
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g1, g2 = groups
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lr = logrank_test(
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df.loc[df[group_col] == g1, time_col],
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df.loc[df[group_col] == g2, time_col],
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df.loc[df[group_col] == g1, event_col],
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df.loc[df[group_col] == g2, event_col],
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)
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p_str = f"P {'< .001' if lr.p_value < 0.001 else f'= {lr.p_value:.3f}'}"
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147
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ax_km.text(0.98, 0.5, f"Log-rank {p_str}",
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transform=ax_km.transAxes, fontsize=8,
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va="center", ha="right")
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150
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print(f"\n Log-rank test: χ² = {lr.test_statistic:.3f}, P = {lr.p_value:.4f}")
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else:
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mlr = multivariate_logrank_test(
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df[time_col], df[group_col], df[event_col]
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)
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155
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p_str = f"P {'< .001' if mlr.p_value < 0.001 else f'= {mlr.p_value:.3f}'}"
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156
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ax_km.text(0.98, 0.5, f"Log-rank {p_str}",
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157
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transform=ax_km.transAxes, fontsize=8,
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158
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va="center", ha="right")
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159
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else:
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160
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# Single-group KM
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161
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kmf = KaplanMeierFitter()
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162
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kmf.fit(df[time_col], df[event_col], label="All patients")
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163
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fitters["All"] = kmf
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164
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kmf.plot_survival_function(ax=ax_km, color=WONG_COLORS[0],
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165
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linewidth=1.5, ci_show=True, ci_alpha=0.2)
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166
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print(f" Median survival: {median_with_ci(kmf, time_unit)}")
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167
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+
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168
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# KM axis formatting
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169
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ax_km.set_ylim(-0.02, 1.05)
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ax_km.set_xlim(left=0)
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ax_km.set_ylabel("Survival probability", fontsize=9)
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ax_km.set_xlabel("")
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ax_km.spines[["top", "right"]].set_visible(False)
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ax_km.legend(fontsize=8, frameon=False)
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ax_km.grid(axis="y", color="#EEEEEE", linewidth=0.5)
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+
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# At-risk table
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ax_risk.set_axis_off()
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+
time_points = np.linspace(0, df[time_col].max() * 0.95, 6)
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+
row_offset = 1.0
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+
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+
for i, (label, kmf) in enumerate(fitters.items()):
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+
at_risk = [kmf.event_table["at_risk"].iloc[
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+
max(0, (kmf.event_table.index <= t).sum() - 1)
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+
] for t in time_points]
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ax_risk.text(-0.01, row_offset - i * 0.35, str(label),
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+
transform=ax_risk.transAxes, fontsize=7.5,
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+
va="top", ha="right",
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+
color=WONG_COLORS[i % len(WONG_COLORS)])
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+
for j, (t, n) in enumerate(zip(time_points, at_risk)):
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+
ax_risk.text(j / (len(time_points) - 1), row_offset - i * 0.35,
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+
str(int(n)), transform=ax_risk.transAxes,
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+
fontsize=7.5, va="top", ha="center")
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+
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+
ax_km.set_xticks(time_points)
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ax_km.set_xlabel(time_unit, fontsize=9)
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+
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plt.suptitle("Kaplan-Meier Survival Curves", fontsize=10, y=1.01, fontweight="bold")
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+
plt.tight_layout()
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+
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+
for ext in ["pdf", "png"]:
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outfile = f"{output_path}_km.{ext}"
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+
dpi = 300 if ext == "png" else None
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plt.savefig(outfile, dpi=dpi, bbox_inches="tight",
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+
facecolor="white", edgecolor="none")
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+
print(f"Saved: {outfile}")
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plt.close()
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+
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+
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+
def cox_analysis(df, time_col, event_col, covariates, output_path="survival",
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+
cluster_col=None):
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+
"""Cox proportional hazards model.
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+
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+
cluster_col: id column for nested observation units (e.g. multiple lesions /
|
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+
eyes / repeated episodes per subject). When set, lifelines computes a robust
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216
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+
(cluster-sandwich) variance so the HR CIs reflect within-subject correlation
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|
+
rather than treating correlated rows as independent.
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+
"""
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+
keep = [time_col, event_col] + covariates + ([cluster_col] if cluster_col else [])
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+
model_df = df[keep].dropna()
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|
+
print(f"\n── Cox PH Model (N = {len(model_df)}) ───────────────────────")
|
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222
|
+
|
|
223
|
+
# Events-per-variable (EPV) gate — mirror of the logistic EPV rule. A Wald CI
|
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|
+
# from a sparse-event model is not stable; warn and rely on the penalizer.
|
|
225
|
+
n_events = int(model_df[event_col].sum())
|
|
226
|
+
epv = n_events / max(len(covariates), 1)
|
|
227
|
+
print(f"EPV = {epv:.1f} ({n_events} events / {len(covariates)} covariates; "
|
|
228
|
+
f"minimum recommended: 10)")
|
|
229
|
+
if epv < 10:
|
|
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|
+
print("⚠ WARNING: EPV < 10 — Cox estimates may be unstable. The penalized "
|
|
231
|
+
"fit (penalizer=0.1) shrinks coefficients; consider Firth/penalized "
|
|
232
|
+
"Cox or profile-likelihood CIs and interpret Wald CIs with caution.")
|
|
233
|
+
|
|
234
|
+
cph = CoxPHFitter(penalizer=0.1)
|
|
235
|
+
fit_kw = {"duration_col": time_col, "event_col": event_col}
|
|
236
|
+
if cluster_col:
|
|
237
|
+
fit_kw["cluster_col"] = cluster_col # robust (cluster-sandwich) SE
|
|
238
|
+
print(f"Robust cluster-sandwich SE on '{cluster_col}' (nested units).")
|
|
239
|
+
cph.fit(model_df, **fit_kw)
|
|
240
|
+
cph.print_summary()
|
|
241
|
+
|
|
242
|
+
# Check PH assumption
|
|
243
|
+
print("\n── Proportional Hazards Assumption (Schoenfeld residuals) ───")
|
|
244
|
+
try:
|
|
245
|
+
cph.check_assumptions(model_df, p_value_threshold=0.05, show_plots=False)
|
|
246
|
+
except Exception as e:
|
|
247
|
+
print(f" PH assumption check: {e}")
|
|
248
|
+
|
|
249
|
+
# Save results table
|
|
250
|
+
summary = cph.summary.copy()
|
|
251
|
+
summary.columns = [c.replace(" ", "_") for c in summary.columns]
|
|
252
|
+
outfile = f"{output_path}_cox_results.csv"
|
|
253
|
+
summary.to_csv(outfile)
|
|
254
|
+
print(f"\nSaved: {outfile}")
|
|
255
|
+
|
|
256
|
+
# Concordance index
|
|
257
|
+
print(f"\nConcordance index (C-statistic): {cph.concordance_index_:.3f}")
|
|
258
|
+
|
|
259
|
+
return cph
|
|
260
|
+
|
|
261
|
+
|
|
262
|
+
def rmst_analysis(df, time_col, event_col, group_col, t_star, output_path="survival"):
|
|
263
|
+
"""Restricted Mean Survival Time analysis."""
|
|
264
|
+
if group_col not in df.columns:
|
|
265
|
+
return
|
|
266
|
+
|
|
267
|
+
groups = df[group_col].dropna().unique()
|
|
268
|
+
print(f"\n── Restricted Mean Survival Time (t* = {t_star}) ────────────")
|
|
269
|
+
for g in groups:
|
|
270
|
+
d = df[df[group_col] == g]
|
|
271
|
+
kmf = KaplanMeierFitter()
|
|
272
|
+
kmf.fit(d[time_col], d[event_col])
|
|
273
|
+
rmst = restricted_mean_survival_time(kmf, t=t_star)
|
|
274
|
+
print(f" {g}: RMST = {rmst:.2f}")
|
|
275
|
+
|
|
276
|
+
|
|
277
|
+
def main():
|
|
278
|
+
parser = argparse.ArgumentParser(description="Survival analysis")
|
|
279
|
+
parser.add_argument("--input", required=True)
|
|
280
|
+
parser.add_argument("--time", required=True, help="Time column name")
|
|
281
|
+
parser.add_argument("--event", required=True, help="Event column name (1=event, 0=censored)")
|
|
282
|
+
parser.add_argument("--group", default=None)
|
|
283
|
+
parser.add_argument("--covariates", nargs="+", default=None)
|
|
284
|
+
parser.add_argument("--cluster", default=None,
|
|
285
|
+
help="ID column for nested units → robust cluster SE in Cox")
|
|
286
|
+
parser.add_argument("--time-unit", default="Months")
|
|
287
|
+
parser.add_argument("--rmst-t", type=float, default=None,
|
|
288
|
+
help="t* for RMST (in same units as time)")
|
|
289
|
+
parser.add_argument("--output", default="survival_analysis")
|
|
290
|
+
|
|
291
|
+
args = parser.parse_args()
|
|
292
|
+
|
|
293
|
+
df = load_data(args.input, args.time, args.event)
|
|
294
|
+
print(f"\nN = {len(df)} | Events: {df[args.event].sum()} "
|
|
295
|
+
f"({df[args.event].mean()*100:.1f}%)")
|
|
296
|
+
|
|
297
|
+
print("\n── Kaplan-Meier Analysis ────────────────────")
|
|
298
|
+
km_analysis(df, args.time, args.event, args.group,
|
|
299
|
+
args.time_unit, args.output)
|
|
300
|
+
|
|
301
|
+
if args.covariates:
|
|
302
|
+
cox_analysis(df, args.time, args.event, args.covariates, args.output,
|
|
303
|
+
cluster_col=args.cluster)
|
|
304
|
+
|
|
305
|
+
if args.rmst_t and args.group:
|
|
306
|
+
rmst_analysis(df, args.time, args.event, args.group,
|
|
307
|
+
args.rmst_t, args.output)
|
|
308
|
+
|
|
309
|
+
print(f"\n── Session Info ─────────────────────────────")
|
|
310
|
+
print(f"Python: {sys.version.split()[0]}")
|
|
311
|
+
for pkg in ["lifelines", "pandas", "numpy", "scipy"]:
|
|
312
|
+
try:
|
|
313
|
+
import importlib
|
|
314
|
+
m = importlib.import_module(pkg)
|
|
315
|
+
print(f" {pkg}: {m.__version__}")
|
|
316
|
+
except Exception:
|
|
317
|
+
pass
|
|
318
|
+
|
|
319
|
+
|
|
320
|
+
if __name__ == "__main__":
|
|
321
|
+
if len(sys.argv) == 1:
|
|
322
|
+
print("Usage: python survival_analysis.py --input data.csv "
|
|
323
|
+
"--time time_months --event event --group treatment")
|
|
324
|
+
else:
|
|
325
|
+
main()
|
|
@@ -0,0 +1,287 @@
|
|
|
1
|
+
"""
|
|
2
|
+
Template: Table 1 — Baseline Demographics
|
|
3
|
+
Generates a publication-ready demographics table from tabular data.
|
|
4
|
+
|
|
5
|
+
Usage:
|
|
6
|
+
Modify the CONFIGURATION section below, then run:
|
|
7
|
+
python table1_demographics.py
|
|
8
|
+
|
|
9
|
+
Input: CSV or Excel file with one row per subject
|
|
10
|
+
Output: table1_demographics.csv, table1_demographics.md (console), summary text
|
|
11
|
+
"""
|
|
12
|
+
|
|
13
|
+
# === REPRODUCIBILITY HEADER ===
|
|
14
|
+
import sys
|
|
15
|
+
import datetime
|
|
16
|
+
import numpy as np
|
|
17
|
+
import pandas as pd
|
|
18
|
+
from scipy import stats
|
|
19
|
+
|
|
20
|
+
np.random.seed(42)
|
|
21
|
+
print(f"Date: {datetime.date.today()}")
|
|
22
|
+
print(f"Python: {sys.version}")
|
|
23
|
+
print(f"numpy: {np.__version__}, pandas: {pd.__version__}, scipy: {stats.scipy.__version__}")
|
|
24
|
+
print()
|
|
25
|
+
|
|
26
|
+
# === CONFIGURATION (modify for your study) ===
|
|
27
|
+
INPUT_FILE = "data.csv" # Path to input data
|
|
28
|
+
OUTPUT_DIR = "." # Output directory
|
|
29
|
+
GROUP_COL = None # Column name for group comparison (None = no comparison)
|
|
30
|
+
CONTINUOUS_VARS = [] # List of continuous variable column names
|
|
31
|
+
CATEGORICAL_VARS = [] # List of categorical variable column names
|
|
32
|
+
VAR_LABELS = {} # Optional display labels: {"col_name": "Display Name (unit)"}
|
|
33
|
+
DECIMAL_PLACES = 1 # Decimal places for continuous variables
|
|
34
|
+
# ==============================================
|
|
35
|
+
|
|
36
|
+
|
|
37
|
+
def load_data(filepath: str) -> pd.DataFrame:
|
|
38
|
+
"""Load CSV or Excel file."""
|
|
39
|
+
if filepath.endswith((".xlsx", ".xls")):
|
|
40
|
+
return pd.read_excel(filepath)
|
|
41
|
+
return pd.read_csv(filepath)
|
|
42
|
+
|
|
43
|
+
|
|
44
|
+
def test_normality(series: pd.Series, alpha: float = 0.05) -> tuple:
|
|
45
|
+
"""Test normality using Shapiro-Wilk (n<50) or Kolmogorov-Smirnov (n>=50)."""
|
|
46
|
+
clean = series.dropna()
|
|
47
|
+
if len(clean) < 3:
|
|
48
|
+
return False, np.nan
|
|
49
|
+
if len(clean) < 50:
|
|
50
|
+
stat, p = stats.shapiro(clean)
|
|
51
|
+
else:
|
|
52
|
+
stat, p = stats.kstest(clean, "norm", args=(clean.mean(), clean.std()))
|
|
53
|
+
return p >= alpha, p
|
|
54
|
+
|
|
55
|
+
|
|
56
|
+
def format_continuous(series: pd.Series, is_normal: bool, dp: int = 1) -> str:
|
|
57
|
+
"""Format continuous variable as mean +/- SD or median (IQR)."""
|
|
58
|
+
clean = series.dropna()
|
|
59
|
+
if is_normal:
|
|
60
|
+
return f"{clean.mean():.{dp}f} +/- {clean.std():.{dp}f}"
|
|
61
|
+
else:
|
|
62
|
+
q1, median, q3 = clean.quantile([0.25, 0.5, 0.75])
|
|
63
|
+
return f"{median:.{dp}f} ({q1:.{dp}f}-{q3:.{dp}f})"
|
|
64
|
+
|
|
65
|
+
|
|
66
|
+
def format_categorical(series: pd.Series) -> dict:
|
|
67
|
+
"""Format categorical variable as n (%)."""
|
|
68
|
+
counts = series.value_counts(dropna=False)
|
|
69
|
+
total = len(series)
|
|
70
|
+
result = {}
|
|
71
|
+
for cat, n in counts.items():
|
|
72
|
+
pct = 100.0 * n / total if total > 0 else 0.0
|
|
73
|
+
label = str(cat) if pd.notna(cat) else "Missing"
|
|
74
|
+
result[label] = f"{n} ({pct:.1f}%)"
|
|
75
|
+
return result
|
|
76
|
+
|
|
77
|
+
|
|
78
|
+
def compare_continuous(groups: list, is_normal: bool) -> tuple:
|
|
79
|
+
"""Compare continuous variable between groups."""
|
|
80
|
+
clean_groups = [g.dropna() for g in groups]
|
|
81
|
+
if len(clean_groups) == 2:
|
|
82
|
+
if is_normal:
|
|
83
|
+
stat, p = stats.ttest_ind(*clean_groups)
|
|
84
|
+
return "t-test", p
|
|
85
|
+
else:
|
|
86
|
+
stat, p = stats.mannwhitneyu(*clean_groups, alternative="two-sided")
|
|
87
|
+
return "Mann-Whitney U", p
|
|
88
|
+
else:
|
|
89
|
+
if is_normal:
|
|
90
|
+
stat, p = stats.f_oneway(*clean_groups)
|
|
91
|
+
return "ANOVA", p
|
|
92
|
+
else:
|
|
93
|
+
stat, p = stats.kruskal(*clean_groups)
|
|
94
|
+
return "Kruskal-Wallis", p
|
|
95
|
+
|
|
96
|
+
|
|
97
|
+
def compare_categorical(contingency: pd.DataFrame) -> tuple:
|
|
98
|
+
"""Compare categorical variable between groups using chi-square or Fisher's exact."""
|
|
99
|
+
table = contingency.values
|
|
100
|
+
# Use Fisher's exact test for 2x2 tables with any expected count < 5
|
|
101
|
+
if table.shape == (2, 2):
|
|
102
|
+
expected = stats.chi2_contingency(table, correction=False)[3]
|
|
103
|
+
if (expected < 5).any():
|
|
104
|
+
odds_ratio, p = stats.fisher_exact(table)
|
|
105
|
+
return "Fisher's exact", p
|
|
106
|
+
# Otherwise chi-square (with Yates' correction for 2x2)
|
|
107
|
+
chi2, p, dof, expected = stats.chi2_contingency(table)
|
|
108
|
+
if (expected < 5).any():
|
|
109
|
+
print(f" Warning: expected counts < 5 in some cells; consider collapsing categories.")
|
|
110
|
+
return "Chi-square", p
|
|
111
|
+
|
|
112
|
+
|
|
113
|
+
def format_p(p: float) -> str:
|
|
114
|
+
"""Format p-value per reporting rules."""
|
|
115
|
+
if pd.isna(p):
|
|
116
|
+
return ""
|
|
117
|
+
if p < 0.001:
|
|
118
|
+
return "<0.001"
|
|
119
|
+
return f"{p:.3f}"
|
|
120
|
+
|
|
121
|
+
|
|
122
|
+
def build_table1(df: pd.DataFrame) -> pd.DataFrame:
|
|
123
|
+
"""Build the full Table 1 dataframe."""
|
|
124
|
+
rows = []
|
|
125
|
+
test_footnotes = set()
|
|
126
|
+
|
|
127
|
+
if GROUP_COL and GROUP_COL in df.columns:
|
|
128
|
+
groups = df[GROUP_COL].dropna().unique()
|
|
129
|
+
groups = sorted(groups, key=str)
|
|
130
|
+
group_dfs = {str(g): df[df[GROUP_COL] == g] for g in groups}
|
|
131
|
+
else:
|
|
132
|
+
groups = []
|
|
133
|
+
group_dfs = {}
|
|
134
|
+
|
|
135
|
+
n_row = {"Variable": "n"}
|
|
136
|
+
if group_dfs:
|
|
137
|
+
for g_name, g_df in group_dfs.items():
|
|
138
|
+
n_row[g_name] = str(len(g_df))
|
|
139
|
+
n_row["Overall"] = str(len(df))
|
|
140
|
+
if group_dfs:
|
|
141
|
+
n_row["p-value"] = ""
|
|
142
|
+
n_row["Test"] = ""
|
|
143
|
+
rows.append(n_row)
|
|
144
|
+
|
|
145
|
+
# --- Continuous variables ---
|
|
146
|
+
for var in CONTINUOUS_VARS:
|
|
147
|
+
if var not in df.columns:
|
|
148
|
+
print(f"Warning: '{var}' not found in data, skipping.")
|
|
149
|
+
continue
|
|
150
|
+
label = VAR_LABELS.get(var, var)
|
|
151
|
+
is_normal, norm_p = test_normality(df[var])
|
|
152
|
+
stat_type = "mean +/- SD" if is_normal else "median (IQR)"
|
|
153
|
+
|
|
154
|
+
row = {"Variable": f"{label}, {stat_type}"}
|
|
155
|
+
row["Overall"] = format_continuous(df[var], is_normal, DECIMAL_PLACES)
|
|
156
|
+
|
|
157
|
+
if group_dfs:
|
|
158
|
+
for g_name, g_df in group_dfs.items():
|
|
159
|
+
row[g_name] = format_continuous(g_df[var], is_normal, DECIMAL_PLACES)
|
|
160
|
+
grp_series = [g_df[var] for g_df in group_dfs.values()]
|
|
161
|
+
test_name, p_val = compare_continuous(grp_series, is_normal)
|
|
162
|
+
row["p-value"] = format_p(p_val)
|
|
163
|
+
row["Test"] = test_name
|
|
164
|
+
test_footnotes.add(test_name)
|
|
165
|
+
|
|
166
|
+
rows.append(row)
|
|
167
|
+
|
|
168
|
+
# --- Categorical variables ---
|
|
169
|
+
for var in CATEGORICAL_VARS:
|
|
170
|
+
if var not in df.columns:
|
|
171
|
+
print(f"Warning: '{var}' not found in data, skipping.")
|
|
172
|
+
continue
|
|
173
|
+
label = VAR_LABELS.get(var, var)
|
|
174
|
+
|
|
175
|
+
# Header row for this variable
|
|
176
|
+
header_row = {"Variable": f"{label}, n (%)"}
|
|
177
|
+
|
|
178
|
+
if group_dfs:
|
|
179
|
+
contingency = pd.crosstab(df[var], df[GROUP_COL])
|
|
180
|
+
test_name, p_val = compare_categorical(contingency)
|
|
181
|
+
header_row["p-value"] = format_p(p_val)
|
|
182
|
+
header_row["Test"] = test_name
|
|
183
|
+
test_footnotes.add(test_name)
|
|
184
|
+
for g_name in group_dfs:
|
|
185
|
+
header_row[g_name] = ""
|
|
186
|
+
header_row["Overall"] = ""
|
|
187
|
+
rows.append(header_row)
|
|
188
|
+
|
|
189
|
+
# Category rows
|
|
190
|
+
all_cats = format_categorical(df[var])
|
|
191
|
+
for cat_label, cat_val in all_cats.items():
|
|
192
|
+
cat_row = {"Variable": f" {cat_label}"}
|
|
193
|
+
cat_row["Overall"] = cat_val
|
|
194
|
+
if group_dfs:
|
|
195
|
+
for g_name, g_df in group_dfs.items():
|
|
196
|
+
cat_counts = format_categorical(g_df[var])
|
|
197
|
+
cat_row[g_name] = cat_counts.get(cat_label, "0 (0.0%)")
|
|
198
|
+
cat_row["p-value"] = ""
|
|
199
|
+
cat_row["Test"] = ""
|
|
200
|
+
rows.append(cat_row)
|
|
201
|
+
|
|
202
|
+
# Build dataframe
|
|
203
|
+
table_df = pd.DataFrame(rows)
|
|
204
|
+
|
|
205
|
+
# Reorder columns
|
|
206
|
+
col_order = ["Variable"]
|
|
207
|
+
if group_dfs:
|
|
208
|
+
col_order += [str(g) for g in sorted(groups, key=str)]
|
|
209
|
+
col_order += ["Overall"]
|
|
210
|
+
if group_dfs:
|
|
211
|
+
col_order += ["p-value", "Test"]
|
|
212
|
+
table_df = table_df[col_order]
|
|
213
|
+
|
|
214
|
+
print("\n--- Test Methods Used ---")
|
|
215
|
+
for t in sorted(test_footnotes):
|
|
216
|
+
print(f" - {t}")
|
|
217
|
+
print()
|
|
218
|
+
|
|
219
|
+
return table_df
|
|
220
|
+
|
|
221
|
+
|
|
222
|
+
def save_outputs(table_df: pd.DataFrame) -> None:
|
|
223
|
+
"""Save table as CSV and print markdown version."""
|
|
224
|
+
import os
|
|
225
|
+
csv_path = os.path.join(OUTPUT_DIR, "table1_demographics.csv")
|
|
226
|
+
|
|
227
|
+
# Save CSV (without Test column for manuscript)
|
|
228
|
+
export_df = table_df.drop(columns=["Test"], errors="ignore")
|
|
229
|
+
export_df.to_csv(csv_path, index=False)
|
|
230
|
+
print(f"Saved: {csv_path}")
|
|
231
|
+
|
|
232
|
+
# Print markdown table
|
|
233
|
+
print("\n--- Table 1. Baseline Characteristics ---\n")
|
|
234
|
+
print(export_df.to_markdown(index=False))
|
|
235
|
+
|
|
236
|
+
|
|
237
|
+
def print_results_text(df: pd.DataFrame, table_df: pd.DataFrame) -> None:
|
|
238
|
+
"""Print copy-paste-ready text for Results section."""
|
|
239
|
+
print("\n--- Results Text (copy-paste ready) ---\n")
|
|
240
|
+
n_total = len(df)
|
|
241
|
+
|
|
242
|
+
if GROUP_COL and GROUP_COL in df.columns:
|
|
243
|
+
groups = df[GROUP_COL].dropna().unique()
|
|
244
|
+
group_counts = df[GROUP_COL].value_counts()
|
|
245
|
+
parts = [f"{g} (n = {group_counts[g]})" for g in sorted(groups, key=str)]
|
|
246
|
+
print(f"A total of {n_total} subjects were included and divided into "
|
|
247
|
+
f"{len(groups)} groups: {', '.join(parts)}. "
|
|
248
|
+
f"Baseline characteristics are summarized in Table 1.")
|
|
249
|
+
else:
|
|
250
|
+
print(f"A total of {n_total} subjects were included. "
|
|
251
|
+
f"Baseline characteristics are summarized in Table 1.")
|
|
252
|
+
|
|
253
|
+
# Report missing data
|
|
254
|
+
missing = df[CONTINUOUS_VARS + CATEGORICAL_VARS].isnull().sum()
|
|
255
|
+
missing = missing[missing > 0]
|
|
256
|
+
if len(missing) > 0:
|
|
257
|
+
print(f"\nMissing data: ", end="")
|
|
258
|
+
parts = [f"{VAR_LABELS.get(col, col)}: {n} ({100*n/len(df):.1f}%)"
|
|
259
|
+
for col, n in missing.items()]
|
|
260
|
+
print("; ".join(parts) + ".")
|
|
261
|
+
|
|
262
|
+
|
|
263
|
+
# === MAIN ===
|
|
264
|
+
if __name__ == "__main__":
|
|
265
|
+
print("=" * 60)
|
|
266
|
+
print("Table 1: Baseline Demographics")
|
|
267
|
+
print("=" * 60)
|
|
268
|
+
|
|
269
|
+
df = load_data(INPUT_FILE)
|
|
270
|
+
print(f"\nLoaded: {INPUT_FILE} ({df.shape[0]} rows, {df.shape[1]} columns)")
|
|
271
|
+
|
|
272
|
+
# Auto-detect if CONTINUOUS_VARS and CATEGORICAL_VARS are empty
|
|
273
|
+
if not CONTINUOUS_VARS and not CATEGORICAL_VARS:
|
|
274
|
+
print("\nNo variables specified. Auto-detecting from data types...")
|
|
275
|
+
for col in df.columns:
|
|
276
|
+
if col == GROUP_COL:
|
|
277
|
+
continue
|
|
278
|
+
if pd.api.types.is_numeric_dtype(df[col]) and df[col].nunique() > 10:
|
|
279
|
+
CONTINUOUS_VARS.append(col)
|
|
280
|
+
print(f" Continuous: {col}")
|
|
281
|
+
elif df[col].nunique() <= 20:
|
|
282
|
+
CATEGORICAL_VARS.append(col)
|
|
283
|
+
print(f" Categorical: {col}")
|
|
284
|
+
|
|
285
|
+
table_df = build_table1(df)
|
|
286
|
+
save_outputs(table_df)
|
|
287
|
+
print_results_text(df, table_df)
|