medsci-skills 4.1.0

package/skills/write-paper/references/journal_profiles/Academic_Radiology.md

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+# Academic Radiology
+
+## Journal Identity
+
+- **Full name**: Academic Radiology
+- **Abbreviation**: Acad Radiol
+- **Publisher**: Elsevier (Association of Academic Radiology)
+- **ISSN**: Not specified in guidelines
+- **Frequency**: Monthly
+- **Impact Factor**: Not specified in guidelines
+- **Open Access**: Hybrid (subscription + OA option)
+- **APC**: See Elsevier OA policies
+
+## Manuscript Types and Word Limits
+
+| Type | Abstract | Manuscript Body | References | Figures/Tables |
+|------|----------|----------------|------------|----------------|
+| Original Investigation | 200 w (structured) | No strict cap | No cap | No strict cap |
+| Clinical Review / Systematic Review | 250 w | 5,000 | 100 | 5 T + 10 F |
+| Innovations | 200 w | 2,500 | 15 | 5 |
+| Perspectives | None | 2,000 | 20 | 2 |
+| Beyond Academic Radiology | None | 1,000 | 10 | 2 |
+| White Papers | None | 5,000 | 50 | 5 |
+| Letter to the Editor | None | 500 | 5 | 0 |
+
+Word counts exclude abstract, references, figure legends, and tables.
+
+## Abstract Format
+
+Structured with four headings (for Original Investigations):
+1. **Background**
+2. **Methods**
+3. **Results**
+4. **Conclusion**
+
+Maximum 200 words (Original Investigation) or 250 words (Clinical Review).
+No abbreviations unless established. No references in abstract.
+
+## Keywords
+
+3-5 keywords on the title page.
+
+## Required Sections
+
+1. **Introduction**
+2. **Material and Methods**
+3. **Results**
+4. **Conclusions**
+
+Additional required elements:
+- **Take-Home Messages**: 1-2 bullet points (max 50 words total) for Original Investigations; up to 3 for Clinical Reviews
+- **Title page** (separate): title, authors, affiliations, corresponding author, keywords, disclosures, funding, AI declaration
+- **Blinded manuscript** (separate): no author-identifying information (double-blind review)
+- **Acknowledgements** (separate file)
+
+## Citation Style
+
+- Vancouver (numbered) style
+- Numbered sequentially in order of first appearance
+- DOI highly encouraged
+- Journal abbreviations per ISSN List of Title Word Abbreviations
+- Example: `Boyko A, Qureshi MM, Fishman MDC, Slanetz PJ. Predictors of breast cancer outcome... Acad Radiol. 2024;31(5):1727-1734. doi: 10.1016/j.acra.2023.11.037.`
+
+## Reporting Guidelines
+
+| Study Type | Required Guideline |
+|------------|-------------------|
+| Systematic reviews / meta-analyses | PRISMA |
+| Observational studies | STROBE |
+| Quality improvement | SQUIRE |
+| AI/ML studies | CLAIM |
+| Randomized trials | CONSORT |
+
+## Statistical Reporting
+
+Follows standard biomedical statistical reporting conventions:
+- Report exact p-values; use P < .001 only when value is below that threshold.
+- 95% CI required for all primary outcomes.
+- For AI/ML studies: CLAIM checklist compliance required; discrimination and calibration both expected.
+- Effect sizes with units; identify specific statistical tests used.
+- Statistical software and version must be named in Methods.
+- No journal-specific statistical reporting requirements beyond standard practice; SAMPL guidelines recommended as reference.
+
+## Special Notes
+
+- **Double-blind review**: author information must be completely removed from the blinded manuscript file.
+- **AI declaration mandatory**: generative AI use must be declared; failure to disclose leads to automatic rejection and possible submission ban.
+- **Co-first authors**: up to two allowed; no co-senior authors accepted.
+- **Proof turnaround**: 48 hours.
+- Drug/instrument names: use generic name first, then trade name with manufacturer and location in parentheses.

package/skills/write-paper/references/journal_profiles/Annals_of_Internal_Medicine.md

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+# Journal Profile: Annals of Internal Medicine
+
+## Journal Identity
+
+- **Full name**: Annals of Internal Medicine
+- **Abbreviation**: Ann Intern Med
+- **Publisher**: American College of Physicians (ACP)
+- **ISSN**: 0003-4819 (print), 1539-3704 (online)
+- **Frequency**: Monthly (12 issues/year + online-first)
+- **Impact Factor**: ~39 (JCR 2023), top-5 general/internal medicine journal
+- **Open Access**: Hybrid (optional OA; standard subscription)
+- **Acceptance rate**: ~5% for Original Research
+- **Peer review**: Double-blind; dedicated statistical reviewers
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures/Tables |
+|------|----------------|----------|------------|----------------|
+| Original Research | 3000 words | 325 words (structured) | 50 | 6 |
+| Review | 4000 words | 250 words | 75 | 6 |
+| Research Letter | 600 words | None | 6 | 1 |
+| Ideas and Opinions | 1200 words | None | 10 | 1 |
+| Clinical Guidelines | By invitation | 250 words | Varies | Varies |
+| Systematic Review | 3500 words | 325 words | 75 | 6 |
+
+Word counts exclude abstract, references, tables, figure legends, and appendices.
+
+---
+
+## Abstract Requirements
+
+**Structured abstract, 325 words maximum:**
+
+```
+Background: [Context and knowledge gap — 2-3 sentences]
+Objective: [Specific aims]
+Design: [Study design (e.g., retrospective cohort, RCT)]
+Setting: [Single center/multi-center, country]
+Participants: [Eligibility, sample size]
+Intervention: [If applicable]
+Measurements: [Primary and secondary outcomes]
+Results: [Key results with effect sizes, CIs, P values]
+Limitation: [1-2 key limitations]
+Conclusion: [Main conclusion answering the Objective]
+Primary Funding Source: [Funder name]
+```
+
+**Unique feature**: Annals includes "Limitation" as an abstract heading — the only major general journal to do so. Do not omit this.
+
+---
+
+## Required Journal-Specific Elements
+
+### 1. Visual Abstract (Encouraged)
+
+Annals encourages a single-page graphical summary suitable for social media. Not required but strongly recommended for visibility.
+
+### 2. Summaries for Patients
+
+For all Original Research articles, Annals publishes a plain-language "Summaries for Patients" companion. Authors may be asked to draft this (~300 words, written at 8th-grade reading level).
+
+### 3. Appendix
+
+Detailed methods, supplementary tables/figures, sensitivity analyses go in an online Appendix (no word limit). Referenced from main text.
+
+---
+
+## Required Sections (Original Research)
+
+1. **Introduction** — concise (2 paragraphs); end with clear objective
+2. **Methods**
+   - Study Design and Oversight: IRB approval, registration (ClinicalTrials.gov for RCTs)
+   - Participants and Setting: eligibility, recruitment, sites
+   - Measurements/Interventions
+   - Statistical Analysis: pre-specified, power calculation, missing data handling, sensitivity analyses
+   - Role of the Funding Source: explicit statement
+3. **Results** — begin with participant flow; baseline table; primary then secondary outcomes
+4. **Discussion** — start with key findings; compare with literature; Limitations paragraph; conclude with implications
+5. **Appendix** — detailed methods, supplementary analyses
+
+---
+
+## Statistical Reporting
+
+Annals of Internal Medicine has historically championed transparent statistical reporting:
+- Report exact P values (e.g., P = .04); use P < .001 below that threshold.
+- 95% CI required for all primary outcomes; preferred over P values alone.
+- Effect sizes in clinically meaningful units (absolute risk difference, NNT/NNH, mean difference with units).
+- For diagnostic accuracy: report sensitivity, specificity, and likelihood ratios with CIs.
+- Prediction models: calibration required (Hosmer-Lemeshow or calibration plot); discrimination alone insufficient.
+- Report both unadjusted and adjusted results for observational studies.
+- Multiple comparisons: describe approach; secondary analyses should be labeled exploratory.
+- Missing data: state the amount and handling method (complete case, imputation).
+- Power calculation with assumptions stated for all prospective studies.
+- Statistical software and version must be identified in Methods.
+
+**Note**: Annals published the TRIPOD statement (Moons et al., 2015) and enforces its items rigorously for prediction model papers.
+
+---
+
+## Figures
+
+- **Maximum 6 figures/tables combined**
+- **Resolution**: 300 DPI (600 DPI for line art)
+- **Format**: TIFF, EPS, or high-resolution PDF
+- **Color**: Free online; grayscale for print
+- **Appendix figures**: Unlimited (online only)
+- **Multi-panel**: Counts as one figure; label A, B, C
+
+---
+
+## Common Rejection Reasons
+
+1. **Too specialized for internal medicine audience** — Annals expects relevance to practicing internists; pure subspecialty or methodological papers should target specialty journals
+2. **Missing Limitation in abstract** — unique to Annals; omission signals unfamiliarity with journal
+3. **Underpowered or single-center** — Annals favors large multi-center studies
+4. **Observational study with causal claims** — editors and statistical reviewers scrutinize causal language
+5. **No clinical endpoint** — surrogate outcomes insufficient unless no alternative exists
+6. **AI study without clinical utility demonstration** — must show impact on clinical decision-making, not just accuracy
+7. **Incomplete reporting** — Annals requires adherence to EQUATOR guidelines; missing checklist items flagged
+
+---
+
+## Cover Letter
+
+Must include:
+- Why this study is important for Annals' readership (internists and generalists)
+- Key finding in 1-2 sentences
+- Statement of originality
+- Disclosure of related submissions
+- Suggested reviewers (optional)
+
+---
+
+## Author Guidelines URL
+
+https://www.acpjournals.org/journal/aim/authors
+
+---
+
+## Positioning
+
+Annals of Internal Medicine is appropriate when:
+- Large prospective or multi-center study relevant to internal medicine practice
+- Systematic review or meta-analysis following PRISMA rigorously
+- Diagnostic accuracy study affecting common clinical decisions (screening, triage)
+- Prediction model validated externally with clinical decision impact
+- Health policy study with evidence-based recommendations
+
+Not appropriate for: pure radiology methodology, small pilot studies, AI technical papers without clinical integration, narrow subspecialty findings.

package/skills/write-paper/references/journal_profiles/Artificial_Intelligence_in_Medicine.md

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+# Artificial Intelligence in Medicine
+
+## Journal Identity
+
+- **Full name**: Artificial Intelligence in Medicine
+- **Abbreviation**: Artif Intell Med
+- **Publisher**: Elsevier
+- **ISSN**: 0933-3657 (print) / 1873-2860 (online)
+- **Frequency**: Continuous
+- **Impact Factor**: ~6.2 (2024)
+- **Open Access**: Hybrid (subscription + Gold OA option)
+- **APC**: USD 3,310
+
+## Manuscript Types and Word Limits
+
+| Type | Abstract | Manuscript Body | References | Notes |
+|------|----------|----------------|------------|-------|
+| Original Research | 250 w | No strict cap | No cap | Must show AI novelty + medical impact |
+| Methodological Review/Survey | 250 w | No strict cap | No cap | Classify and critically analyze methods |
+| Position Paper | 250 w | No strict cap | No cap | Scientific challenges of a field |
+| Letter to the Editor | 250 w | Short | No cap | Comment on recent articles |
+| PhD Project | 250 w | Short | No cap | Overall goals, not detailed results |
+
+Mere application of known algorithms to medical data is NOT considered original.
+
+## Abstract Format
+
+Unstructured, maximum 250 words.
+State purpose, principal results, and major conclusions.
+Must stand alone; avoid references. Define non-standard abbreviations at first mention.
+
+## Keywords
+
+1-7 keywords. Avoid multi-word keywords using "and"/"or". Use established abbreviations only.
+
+## Required Sections
+
+1. **Introduction**
+2. **Material and Methods**
+3. **Results**
+4. **Discussion**
+5. **Conclusions**
+
+Additional required elements:
+- **Highlights**: separate file, 3-5 bullet points, max 85 characters each (including spaces)
+- **CRediT Author Contributions**: mandatory
+- **Acknowledgements**: separate section before references
+- **Numbered sections** (1, 1.1, 1.2, etc.)
+
+## Citation Style
+
+- Numbered [1], [2] in order of appearance
+- No strict formatting required at submission (any consistent style accepted)
+- After acceptance: numbered Vancouver-like style applied
+- More than 6 authors: list first 6, then "et al."
+- DOI recommended
+- Example: `Van der Geer J, Hanraads JAJ, Lupton RA. The art of writing a scientific article. J Sci Commun 2020;163:51-9. https://doi.org/10.1016/j.sc.2020.00372.`
+
+## Reporting Guidelines
+
+- Follow ICMJE recommendations and Declaration of Helsinki for human studies
+- Clinical trials: register before enrollment; include registration number in title page and abstract; follow CONSORT
+- SAGER guidelines for sex/gender reporting
+
+## Statistical Reporting
+
+Follows ICMJE and SAGER guidelines:
+- Report exact p-values where applicable.
+- 95% CI for primary outcomes; effect sizes with units.
+- For AI model evaluations: discrimination metrics (AUC, F1, accuracy) with CI; calibration expected for prediction models; external or independent test set required.
+- Sex and gender disaggregation of results per SAGER guidelines.
+- Statistical software and version identified in Methods.
+- No journal-specific statistical reporting requirements beyond ICMJE and SAGER are published.
+
+## Special Notes
+
+- **Single-blind review** (reviewers know author identity).
+- **AI-generated images NOT permitted** in artwork (exception: AI as part of research methods).
+- **Clinical assessment strongly recommended**: manuscripts should demonstrate potential clinical impact.
+- **Median review time**: submission to first decision ~12 days; to acceptance ~303 days.
+- Preprints allowed; free posting on SSRN during submission.
+- Self-archiving: 12-month embargo for subscription articles.

package/skills/write-paper/references/journal_profiles/British_Journal_of_Radiology.md

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+# Journal Profile: British Journal of Radiology (BJR)
+
+## Basic Information
+
+- **Publisher:** Oxford University Press (on behalf of The British Institute of Radiology)
+- **Impact Factor:** [TODO: verify at journal site — typically reported in JCR]
+- **ISSN:** 0007-1285 (print) / 1748-880X (online)
+- **Frequency:** 12 issues per year (online)
+- **Scope:** All subspecialties of diagnostic radiology, interventional radiology, nuclear medicine, radiation oncology, radiation physics; particular interest in clinical research, methodology, and translational radiology
+- **Open Access:** Hybrid — optional Open Access under Creative Commons (CC BY or CC BY-NC); APC £2,393 for CC licenses; Read and Publish institutional agreements available
+- **Language:** English only
+
+---
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | Figures | Tables | References |
+|------|----------------|----------|---------|--------|------------|
+| Research Article | 3,000 words | 250 words (structured) | 10 | 5 | 50 |
+| Review | 4,000 words | 200 words (unstructured) | 12 | 5 | 100 |
+| Systematic Review | 3,000 words | 250 words (structured) | 10 | 5 | 50 |
+| Pictorial Review | 1,500 words | 200 words (unstructured) | 15 | 4 | 15 |
+| Guidelines | 4,000 words | 200 words (unstructured) | 12 | 5 | 100 |
+| Short Communication | 2,000 words | 250 words (structured) | 5 | 2 | 15 |
+| Commentary | 1,500 words | 200 words (unstructured) | 4 | 2 | 15 |
+| Letter to Editor | 750 words | None | 2 (max) | — | 10 |
+
+---
+
+## Abstract Requirements
+
+**Structured abstract** (Research Articles, Short Communications, Systematic Reviews) — 250 words, five required headings:
+
+```
+Objectives: [Primary aim of the study]
+Methods: [Design, population, intervention/exposure, comparator, outcome]
+Results: [Key findings with statistics and 95% CIs]
+Conclusions: [Main interpretation]
+Advances in knowledge: [What this study adds]
+```
+
+The "Advances in knowledge" heading is BJR-specific — it must explicitly state the novelty contribution and is checked by reviewers.
+
+**Unstructured abstract** (Reviews, Pictorial Reviews, Guidelines, Commentary) — 200 words, single paragraph.
+
+---
+
+## Required Sections (Research Article)
+
+Standard IMRAD:
+
+1. **Introduction**
+2. **Methods**
+3. **Results**
+4. **Discussion**
+
+Ethics, funding, conflict of interest, and data availability statements are required as separate end-matter sections.
+
+---
+
+## Statistical Reporting
+
+- Measures of variation must be included for all important results
+- Estimates of differences must be provided with 95% confidence limits
+- For diagnostic test evaluation: sensitivity, specificity, and predictive values are required
+- p-value reporting format: [TODO: verify at journal site — follow standard convention]
+- Statistical software identification: [TODO: verify — recommend stating software + version]
+
+---
+
+## Figure Requirements
+
+- **Resolution:** 300 DPI (color), 600 DPI (grayscale/combination), 1,200 DPI (monochrome line art)
+- **Formats accepted:** JPEG, PNG, TIFF, SVG, PDF, EPS
+- **Color:** accepted (online publication is in color)
+- **Maximum:** 10 figures + 5 tables for Research Articles (see manuscript-type table above)
+
+---
+
+## Common Rejection Reasons
+
+1. **Insufficient novelty** — BJR Research Articles are expected to clearly state advancement over existing literature in the dedicated "Advances in knowledge" abstract heading
+2. **Single-center study with limited generalizability** — multi-center or representative cohort designs preferred
+3. **Missing structured abstract elements** — particularly omission of the "Advances in knowledge" line
+4. **Inadequate statistical reporting** — confidence intervals and effect sizes required, not just p-values
+5. **Poor English language quality** — BJR expects professional editing prior to submission
+6. **Pictorial Review without sufficient teaching value** — pictorial submissions must demonstrate clear pedagogical contribution beyond image collection
+
+---
+
+## AI Writing Disclosure Policy
+
+- **Requirement level:** Required (mandatory disclosure)
+- **Permitted scope:** Content generation, image generation, code writing, data processing, translation — all permitted with disclosure; AI tools cannot be listed as authors
+- **Disclosure location:** Both (a) cover letter to editors AND (b) Methods or Acknowledgements section
+- **AI-generated images:** Must be disclosed; AI image policy aligns with COPE/ICMJE guidance
+- **Policy URL:** https://academic.oup.com/bjr/pages/author-guidelines
+
+---
+
+## Cover Letter
+
+Not mandatory per current author guidelines, but recommended; if AI tools were used in manuscript preparation, AI disclosure in the cover letter is required (see AI Writing Disclosure Policy above).
+
+---
+
+## Open Access and APC
+
+- **Hybrid model**: Subscription default; optional Open Access under CC BY or CC BY-NC
+- **APC:** £2,393 (for CC license; may vary — verify at submission)
+- **Read and Publish agreements:** institutional waiver may apply if author's institution has an OUP Read and Publish deal
+
+---
+
+## Peer Review
+
+- **Type:** Double-anonymized peer review (both author and reviewer identities blinded)
+- **Number of reviewers:** Typically 2 reviewers
+- **Turnaround:** [TODO: verify at journal site]
+
+Because BJR uses double-anonymized review, manuscript files (including supplementary materials and registry record PDFs) must be blinded prior to submission. Author identifiers (names, institutions, ORCID, funding grant IDs that identify a specific group) should be removed from all uploaded files except the separately-uploaded title page.
+
+---
+
+## Author Guidelines URL
+
+https://academic.oup.com/bjr/pages/author-guidelines
+
+---
+
+## Positioning
+
+BJR is well-suited for:
+- Clinical radiology research with clear translational impact
+- Methodology and radiation-physics studies that complement clinical findings
+- Studies with explicit "Advances in knowledge" framing
+- Authors seeking a UK/European-oriented general radiology audience with mid-range Q1/Q2 visibility
+
+| Dimension | British Journal of Radiology | Clinical Radiology | European Radiology |
+|-----------|-----------------------------|-------------------|--------------------|
+| Society | British Institute of Radiology | Royal College of Radiologists (UK) | European Society of Radiology |
+| Scope | Diagnostic + interventional + radiation oncology + physics | Diagnostic radiology (general) | Diagnostic radiology (general) |
+| Peer review | Double-anonymized | [varies] | Single-blind |
+| Emphasis | "Advances in knowledge" novelty statement; methodology and physics included | UK-leaning clinical practice | European multi-center studies, AI |
+| OA option | Hybrid (CC BY / CC BY-NC) | Hybrid | Hybrid |
+
+---
+
+## Formatting Notes
+
+- References: Vancouver style (numbered)
+- Units: SI units
+- Abbreviations: define at first use
+- Double-anonymized: blind all uploaded files except title page (see Peer Review section above)
+
+
+---
+
+## Verification
+- **Source:** https://academic.oup.com/bjr/pages/author-guidelines
+- **Date:** 2026-05-21

package/skills/write-paper/references/journal_profiles/CVIR.md

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+# Journal Profile: CardioVascular and Interventional Radiology (CVIR)
+
+## Journal Identity
+
+- **Full name**: CardioVascular and Interventional Radiology
+- **Abbreviation**: Cardiovasc Intervent Radiol
+- **Publisher**: Springer Nature (CIRSE — Cardiovascular and Interventional Radiological Society of Europe)
+- **ISSN**: 0174-1551 (print), 1432-086X (online)
+- **Frequency**: Monthly (12 issues/year)
+- **Impact Factor**: ~3.0 (JCR 2023)
+- **Open Access**: Hybrid (Springer transformative agreements may cover OA)
+- **Acceptance rate**: ~25-30%
+- **Peer review**: Single-blind; 2-3 reviewers per manuscript
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures/Tables |
+|------|----------------|----------|------------|----------------|
+| Original Article | 3500 words | 250 words (structured) | 30 | 6 |
+| Review Article | 5000 words | 250 words | 60 | 8 |
+| Technical Note | 2000 words | 150 words (unstructured) | 15 | 4 |
+| Case Report | 1500 words | 150 words (unstructured) | 10 | 4 |
+| Letter to the Editor | 500 words | None | 5 | 1 |
+| Systematic Review / Meta-Analysis | 4000 words | 250 words (structured) | 50 | 8 |
+
+Word counts exclude abstract, references, tables, and figure legends.
+
+---
+
+## Abstract Requirements
+
+**Structured abstract for Original Articles and SRMAs, 250 words maximum:**
+
+```
+Purpose: [Study aim — 1-2 sentences]
+Materials and Methods: [Design, population, intervention/technique, outcomes,
+    statistical methods]
+Results: [Key results with effect sizes and CIs or p-values]
+Conclusion: [Main conclusion — 1-2 sentences]
+```
+
+**Unstructured abstract for Technical Notes and Case Reports, 150 words maximum.**
+
+---
+
+## Required Sections (Original Article)
+
+1. **Introduction** — brief (2-3 paragraphs); end with study purpose
+2. **Materials and Methods**
+   - Study Design: prospective/retrospective, IRB approval
+   - Patient Population: inclusion/exclusion criteria, recruitment period
+   - Procedure/Intervention: detailed technical description
+   - Outcome Measures: primary (technical success, clinical success) and secondary
+   - Follow-up: imaging and clinical follow-up protocol
+   - Statistical Analysis: software, tests, significance level
+3. **Results** — patient demographics, technical outcomes, clinical outcomes, complications
+4. **Discussion** — comparison with literature, limitations, clinical implications
+5. **Conclusion** — brief (1-2 sentences)
+
+---
+
+## Statistical Reporting
+
+- Report exact p-values (e.g., p = 0.032); use p < 0.001 below that threshold.
+- 95% CI for primary outcomes.
+- For diagnostic/technical studies: sensitivity, specificity, accuracy with CIs.
+- For intervention studies: technical success rate, clinical success rate with definitions.
+- Complication rates with Clavien-Dindo or SIR classification.
+- Kaplan-Meier for time-to-event outcomes; Cox regression for multivariate analysis.
+- For meta-analyses: I-squared, prediction intervals, funnel plot for publication bias.
+- Statistical software and version must be identified.
+
+---
+
+## IR-Specific Requirements
+
+### Complication Reporting
+
+CVIR expects standardized complication classification:
+- **SIR Classification** (Society of Interventional Radiology): Minor (A, B) and Major (C, D, E, F)
+- **Clavien-Dindo** for post-procedural complications
+- Report per-patient and per-procedure rates separately
+
+### Technical Outcome Definitions
+
+Define clearly:
+- **Technical success**: procedure completed as intended (specific criteria)
+- **Clinical success**: symptom improvement or target outcome achieved (specific criteria and timepoint)
+- **Primary patency / secondary patency** (for vascular interventions)
+- **Local tumor progression / technique efficacy** (for ablation studies)
+
+### Device and Equipment
+
+Report: device manufacturer, model, size/configuration used. CVIR readers expect this level of procedural detail.
+
+---
+
+## Figures
+
+- **Maximum 6 figures/tables combined** for original articles
+- **Resolution**: 300 DPI minimum
+- **Format**: TIFF, EPS, or high-resolution JPEG
+- **Color**: Free online; grayscale for print
+- **Typical figure set for IR studies**: pre-procedure imaging, procedural images (key steps), post-procedure imaging, follow-up imaging
+
+---
+
+## Common Rejection Reasons
+
+1. **Small sample size without novelty** — single-center retrospective with N < 50 needs strong technical innovation
+2. **Inadequate complication reporting** — missing SIR classification or Clavien-Dindo grading
+3. **Vague technical success definition** — must be operationally defined before the study
+4. **Missing follow-up data** — IR studies need adequate follow-up duration with imaging
+5. **No comparison with existing techniques** — CVIR favors comparative studies
+6. **Overclaiming for observational data** — causal language in retrospective series
+
+---
+
+## Cover Letter
+
+Should emphasize:
+- Relevance to interventional radiology practice in Europe
+- Technical innovation or comparative advantage
+- Patient safety implications
+- Suggested reviewers with IR expertise
+
+---
+
+## Author Guidelines URL
+
+https://www.springer.com/journal/270/submission-guidelines
+
+---
+
+## Positioning
+
+CVIR is appropriate when:
+- Interventional radiology procedure with clinical outcome data (embolization, ablation, drainage, vascular)
+- CBCT-guided interventions with technical or clinical outcomes
+- Comparative study of IR techniques (new vs standard)
+- Systematic review or meta-analysis of IR procedures
+- Technical innovation in IR devices or techniques
+
+Not appropriate for: diagnostic imaging studies without interventional component, pure AI methodology, non-vascular/non-interventional radiology.
+
+---
+
+## Differentiation from JVIR
+
+| Dimension | CVIR | JVIR |
+|-----------|------|------|
+| Society | CIRSE (European) | SIR (American) |
+| Geography emphasis | European and international | North American and international |
+| Impact factor | ~3.0 | ~3.5 |
+| Scope | Cardiovascular + interventional | Interventional (broader) |
+| Meta-analyses | Accepts readily | Accepts readily |
+| Review speed | ~4-6 weeks first decision | ~4-6 weeks first decision |