medsci-skills 4.1.0

package/skills/write-paper/references/journal_profiles/JACC_Asia.md

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+# Journal Profile: JACC: Asia
+
+## Journal Identity
+
+- **Full name**: JACC: Asia
+- **Abbreviation**: JACC Asia
+- **Publisher**: Elsevier (American College of Cardiology Foundation)
+- **ISSN**: 2772-3747 (online)
+- **Frequency**: Monthly
+- **Impact Factor**: Not yet indexed in JCR; SCI indexing expected 2027 (anticipated IF ~5–6) [VERIFY at journal site]
+- **Open Access**: Full Gold OA
+- **Acceptance rate**: Not published [TODO: verify at journal site]
+- **Peer review**: Single-blind, ACC editorial process
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures/Tables | Authors |
+|------|----------------|----------|------------|----------------|---------|
+| Original Investigation | ≤ 5,000 (text + references + figure legends combined) | 250 w (structured) | Within 5,000-word combined cap; Index Medicus abbreviations | Reasonable, no explicit cap | No explicit cap |
+| State-of-the-Art Review | ≤ 10,000 | 250 w (unstructured or structured) | Within combined cap | Reasonable | No explicit cap |
+| Research Letter | ≤ 800 | None | ≤ 5 | 1 figure or table | ≤ 5 typical |
+| Editorial / Viewpoint | Invited; ≤ 1,500 | None | ≤ 10 | None typical | ≤ 3 |
+| Letter to the Editor | ≤ 500 | None | ≤ 5 | None typical | ≤ 3 |
+
+The 5,000-word limit for Original Investigations is **inclusive** of main text, references, and figure legends; abstract, title page, and tables are not counted. Verify against the live Guide for Authors before submission.
+
+---
+
+## Abstract Requirements
+
+Structured, 250 words maximum, with the following 5 mandatory headings:
+
+```
+Background
+Objectives
+Methods
+Results
+Conclusions
+```
+
+Avoid citations and abbreviations in the abstract. Report effect sizes with 95% confidence intervals where applicable.
+
+---
+
+## Required Sections (Original Investigation)
+
+1. **Title page** — full title, short title, authors with degrees and affiliations, ORCID, corresponding author full contact, word/figure/table counts, key words (3–5), funding, conflict of interest disclosures
+2. **Structured Abstract** (Background/Objectives/Methods/Results/Conclusions, 250 w)
+3. **Condensed Abstract / Visual Abstract** (where required by article category)
+4. **Introduction**
+5. **Methods** — must include statistical methods, ethics statement (IRB approval and informed consent or waiver), and data availability statement
+6. **Results**
+7. **Discussion** — must include a Limitations subsection
+8. **Conclusions** (or as last paragraph of Discussion)
+9. **Perspectives** — JACC family signature feature: 2 short bullets ("Competency in …" / "Translational outlook"), each ≤ 50 words
+10. **Acknowledgments** — including AI-tool disclosure if applicable
+11. **Funding Sources / Disclosures** — granular per author; align with ICMJE COI form
+12. **References**
+13. **Figure Legends**
+14. **Tables and Figures**
+
+---
+
+## Statistical Reporting
+
+- Report exact p-values to 2–3 significant figures; use p < 0.001 below threshold; avoid bare "p < 0.05".
+- 95% confidence intervals required for primary effect estimates.
+- Effect sizes with clinically meaningful units (HR, OR, RR, mean difference).
+- Time-to-event analyses: report median follow-up, person-time, KM estimates, and proportional hazards assessment.
+- Pre-specified vs. post-hoc analyses must be labeled.
+- Multiplicity adjustment required when multiple primary endpoints are reported; otherwise note absence and rationale.
+- Statistical software, version, and key packages must be identified in Methods.
+- For prediction or AI-related work, the journal expects calibration plus discrimination, and adherence to TRIPOD+AI / CLAIM as applicable [VERIFY at journal site for AI-specific addenda].
+
+---
+
+## References
+
+- **Style**: Vancouver, **superscript numerals** in citation order in the text.
+- **Author listing**: first 3 authors followed by **et al.** (no period after initials).
+- **Journal abbreviations**: Index Medicus / NLM standard.
+- **DOI**: include where available.
+- **Reference manager**: any (EndNote, Zotero, BBT). The journal accepts standard Vancouver-superscript output; CSL: Vancouver superscript / JACC family.
+
+Example:
+```
+1. Greenland P, Blaha MJ, Budoff MJ, et al. Coronary calcium score and cardiovascular risk. J Am Coll Cardiol. 2018;72(4):434-447.
+```
+
+---
+
+## Figures
+
+- **Maximum**: not explicitly capped; editors expect a number proportionate to a 5,000-word article (typical 3–6 figures plus tables) [VERIFY at journal site]
+- **Resolution**: line art ≥ 1,000 dpi; combination art ≥ 500 dpi; halftone ≥ 300 dpi (Elsevier standard)
+- **Format**: TIFF, EPS, or PDF (vector preferred for line art)
+- **Color**: free in OA articles
+- **Central illustration**: encouraged for Original Investigations — single integrative figure capturing the take-home message; recommended in JACC family
+
+---
+
+## Common Rejection Reasons
+
+1. Cohort or analysis lacks an Asia-specific framing or generalizability argument — reviewers expect explicit positioning relative to Asian epidemiology and healthcare systems.
+2. Word count (text + references + figure legends combined) exceeds 5,000 — frequent technical-check failure.
+3. Structured abstract missing one of the 5 mandatory headings or exceeds 250 words.
+4. Reference style not Vancouver superscript, or > 3 authors listed without et al.
+5. Methods missing IRB statement, data availability statement, or AI-tool disclosure when applicable.
+6. Discrimination metrics for prediction models reported without calibration (or vice versa).
+7. Conclusions over-claim beyond the data (e.g., recommending screening intervals from a single-center retrospective cohort).
+8. Missing Perspectives bullet block or visual / central illustration where the journal requires it.
+
+---
+
+## Cover Letter
+
+Should include:
+- Statement that the manuscript is original, has not been published or submitted elsewhere, and that all authors have approved the submission.
+- 2–4 sentence positioning of why JACC: Asia is the appropriate venue (Asian-data specificity, regional clinical relevance, alignment with the journal's scope).
+- Explicit AI-use disclosure (mirrored in the Acknowledgments).
+- Suggested reviewers (with any conflicts noted) and any preferred-non-reviewers.
+- Conflict of interest summary with reference to ICMJE COI forms.
+- Funding sources.
+
+Avoid over-claiming language beyond what the manuscript supports.
+
+---
+
+## AI Writing Disclosure Policy
+
+- **Requirement level:** Required (follows Elsevier / ICMJE 2024–2025 policy)
+- **Permitted scope:** Language editing and readability improvements only; AI may not be used for study design, data analysis, interpretation, or content generation
+- **Disclosure location:** Cover letter **and** Acknowledgments (dual disclosure)
+- **AI authorship:** Prohibited — AI tools cannot be listed as authors
+- **AI-generated images:** Not permitted unless explicitly declared and justified; original imaging data and figures must be authentic
+- **Policy URL:** https://www.elsevier.com/about/policies-and-standards/the-use-of-generative-ai-and-ai-assisted-technologies-in-writing-for-elsevier
+
+---
+
+## Author Guidelines URL
+
+https://www.sciencedirect.com/journal/jacc-asia/publish/guide-for-authors
+
+---
+
+## Positioning
+
+**Submit here when:**
+- The dataset, cohort, or clinical question is Asian-specific or Asia-Pacific-focused.
+- The work fills an Asian evidence gap relative to predominantly Western cohorts (e.g., MESA, Heinz Nixdorf Recall, CAC Consortium).
+- The audience is Asian cardiologists, imagers, and policy stakeholders.
+- Open-access publication is desired (full Gold OA, regional readership).
+
+**Do NOT submit here when:**
+- The cohort is Western with no specific Asian relevance (consider parent JACC or JACC: Cardiovascular Imaging instead).
+- The methodological scope demands an indexed legacy IF for tenure (the journal is not yet SCI-indexed; anticipated 2027 indexing) — discuss with senior authors before committing.
+- The article requires a non-OA model.
+
+| Dimension | JACC: Asia | JACC | JACC: Cardiovascular Imaging | Circulation: Cardiovascular Imaging |
+|-----------|-----------|------|------------------------------|--------------------------------------|
+| Society | ACC (regional) | ACC | ACC | AHA |
+| Scope | Asian / Asia-Pacific cardiovascular | Global cardiovascular flagship | Cardiovascular imaging (global) | Cardiovascular imaging (global) |
+| Indexing / IF | Not yet SCI-indexed; expected 2027, anticipated IF ~5–6 | SCI Q1 (IF ~24+) | SCI Q1 (IF ~12+) | SCI Q1 (IF ~6+) |
+| Open Access | Full Gold OA | Hybrid | Hybrid | Hybrid |
+| Emphasis | Asian data, regional translation, policy fit | Mechanistic + landmark trials | Imaging mechanism / outcomes | Imaging-focused outcomes |
+| Word limit (Original) | 5,000 (text + refs + legends combined) | 4,500 + abstract | 5,000 | 5,000 |
+
+Use JACC: Asia when Asian-data specificity is the headline of the work; use the parent JACC for landmark global trials, and the imaging-focused sisters when the contribution is primarily methodological imaging science rather than regional epidemiology.

package/skills/write-paper/references/journal_profiles/JACR.md

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+# Journal of the American College of Radiology
+
+## Journal Identity
+
+- **Full name**: Journal of the American College of Radiology
+- **Abbreviation**: J Am Coll Radiol
+- **Publisher**: Elsevier (American College of Radiology)
+- **ISSN**: Not specified in guidelines
+- **Frequency**: Monthly
+- **Impact Factor**: Not specified in guidelines
+- **Open Access**: Hybrid (Gold OA + subscription)
+- **APC**: See Elsevier OA policies
+
+## Manuscript Types and Word Limits
+
+| Type | Abstract | Manuscript Body | References | Figures/Tables | Authors |
+|------|----------|----------------|------------|----------------|---------|
+| Original Article | 250 w (structured) | < 3,000 (excl. refs) | No cap | 7 combined | ≤ 7 |
+| Brief Report | None | ≤ 1,400 (incl. refs) | 8 | 3 combined | Invited only |
+| Opinion | None | ≤ 1,400 (incl. refs) | 8 | No strict cap | ≤ 5 |
+| Letter to the Editor | None | < 500 | 3 | 0 | ≤ 3 |
+
+JACR does NOT publish clinical reviews, book reviews, or case reports.
+
+## Abstract Format
+
+Structured for Original Articles:
+1. **Objective**
+2. **Methods**
+3. **Results**
+4. **Discussion**
+
+Maximum 250 words. Avoid citations in abstract.
+
+## Keywords
+
+3-5 keywords.
+
+## Required Sections
+
+For Original Articles:
+1. Standard IMRAD sections
+2. **Limitations section** (required)
+3. **Summary Sentence**: < 35 words, taken word-for-word from manuscript
+4. **Take Home Points**: 3-6 bulleted principal conclusions (replaces traditional Conclusions)
+
+Additional required elements:
+- **Title**: max 129 characters; no question format
+- **Title page**: author contributions (ICMJE), leadership roles, data statement, funding
+- **Declaration Statement** via Elsevier Declarations tool (separate file)
+- **Blinded manuscript** for initial submission (all author/institution info masked)
+
+## Citation Style
+
+- AMA (American Medical Association) style
+- No specific reference cap for Original Articles (editors may advise)
+- Avoid citations in abstract
+
+## Reporting Guidelines
+
+| Study Type | Required Guideline |
+|------------|-------------------|
+| Randomized trials | CONSORT |
+| Observational studies | STROBE |
+| Systematic reviews | PRISMA |
+| Quality improvement | SQUIRE |
+| AI/ML studies | CLAIM |
+
+## Statistical Reporting
+
+Follows ICMJE and ACR statistical reporting conventions:
+- Report exact p-values where feasible; avoid "P < .05" alone.
+- 95% CI required for primary outcomes in quantitative studies.
+- Health services research: include measures of effect (odds ratios, risk ratios) with CI; report absolute differences alongside relative measures.
+- AI/data science studies: follow CLAIM checklist; discrimination with CI required; calibration required for prediction models.
+- Statistical software and version must be identified in Methods.
+- No journal-specific statistical reporting requirements beyond ICMJE are published.
+
+## Special Notes
+
+- **Five domains**: health services research/policy, clinical practice management, data science, training/education, leadership.
+- **EZ Submit**: initial submission can be a single file (Word or PDF) with figures/tables inline.
+- **Data statement required** on title page for all Original Articles: authors must declare full data access and responsibility.
+- **AI policy**: generative AI only for language/readability improvement; cannot be listed as author; must declare use.
+- **Leadership roles**: all authors must list institutional and ACR leadership roles on title page.
+- **Prior publication/preprint**: must be disclosed; submitted work must be substantively different from prior publications.
+- **Author limits strictly enforced**: Original Article ≤ 7 (EIC approval for more); Opinion ≤ 5; Letter ≤ 3.

package/skills/write-paper/references/journal_profiles/JAMA.md

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+# Journal Profile: JAMA
+
+## Journal Identity
+
+- **Full name**: JAMA (Journal of the American Medical Association)
+- **Abbreviation**: JAMA
+- **Publisher**: American Medical Association (AMA)
+- **ISSN**: 0098-7484 (print), 1538-3598 (online)
+- **Frequency**: Weekly (48 issues/year)
+- **Impact Factor**: ~120 (JCR 2023), ranked 2nd among general medical journals
+- **Open Access**: Hybrid (optional OA with APC ~$5,000)
+- **Acceptance rate**: ~5% for Original Investigations
+- **Peer review**: Single-blind; statistical editor review on all accepted manuscripts
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures/Tables |
+|------|----------------|----------|------------|----------------|
+| Original Investigation | 3000 words | 350 words (structured) | 50 | 5 |
+| Research Letter | 600 words | None | 6 | 1 |
+| Review | 3500 words | 350 words (structured) | 75 | 5 |
+| Viewpoint | 1200 words | None | 12 | 1 |
+| Diagnostic Test Interpretation | 2500 words | None | 20 | 4 |
+| Brief Report | 1800 words | 350 words | 20 | 2 |
+
+Word counts exclude abstract, references, tables, and figure legends.
+
+---
+
+## Abstract Requirements
+
+**Structured abstract, 350 words maximum:**
+
+```
+Importance: [Why this question matters — clinical impact, knowledge gap]
+Objective: [Specific aims — 1 sentence]
+Design, Setting, and Participants: [Study design, setting, eligibility criteria,
+    dates of data collection, follow-up duration]
+Intervention(s) [if applicable]: [Description of interventions/exposures]
+Main Outcomes and Measures: [Primary and secondary outcomes defined]
+Results: [Number enrolled/analyzed, demographic summary, primary results
+    with effect sizes, CIs, and exact P values]
+Conclusions and Relevance: [Main conclusion — 1-2 sentences answering
+    the Objective; clinical relevance]
+```
+
+**Critical**: JAMA's structured abstract has 7 headings (not 4). The "Importance" heading is unique to JAMA and is the first thing editors read.
+
+---
+
+## Required Journal-Specific Elements
+
+### 1. Key Points Box
+
+Placed immediately before the abstract. Three components:
+
+- **Question**: One sentence framing the research question.
+- **Findings**: One sentence with the main quantitative result (effect size + CI).
+- **Meaning**: One sentence stating clinical relevance.
+
+Example:
+```
+Key Points
+
+Question  Does AI-assisted colonoscopy improve adenoma detection rates
+compared with standard colonoscopy?
+
+Findings  In this randomized clinical trial of 3058 patients, AI-assisted
+colonoscopy was associated with a significantly higher adenoma detection
+rate (29.1% vs 20.3%; relative risk, 1.43 [95% CI, 1.22-1.69]).
+
+Meaning  AI-assisted colonoscopy may improve polyp detection in
+routine clinical practice.
+```
+
+### 2. Article Information
+
+- Author affiliations with department, institution, city
+- Corresponding author email
+- Author contributions (CRediT format accepted)
+- Conflict of interest disclosures (ICMJE form required from all authors)
+- Funding/support statement
+- Data sharing statement
+
+---
+
+## Required Sections (Original Investigation)
+
+1. **Introduction** — brief (2-3 paragraphs); end with explicit objective
+2. **Methods**
+   - Ethics: IRB approval with institution name + approval number
+   - Study Design and Participants: inclusion/exclusion, recruitment dates
+   - Interventions or Exposures (if applicable)
+   - Outcomes: primary and secondary clearly defined
+   - Statistical Analysis: software, tests, sample size calculation, handling of multiplicity
+3. **Results** — begin with participant flow and baseline characteristics
+4. **Discussion** — 4-5 paragraphs; begin with key findings summary, end with Limitations paragraph
+5. **Conclusions** — brief (1-2 sentences, matching abstract conclusion)
+
+---
+
+## Statistical Reporting
+
+JAMA has among the most rigorous statistical review processes in medicine:
+- Report exact P values to 2 decimal places (e.g., P = .03); use P < .001 below that threshold.
+- 95% CI required for all primary and key secondary outcomes.
+- Effect sizes with units (absolute risk difference, NNT, hazard ratio, odds ratio).
+- For diagnostic accuracy: sensitivity, specificity, AUC with 95% CI; calibration if prediction model.
+- Sample size justification required in Methods (power calculation with assumptions stated).
+- Report both intention-to-treat and per-protocol analyses for RCTs.
+- Multiple comparisons: pre-specify primary outcome; correct for multiplicity or declare secondary analyses as exploratory.
+- Means with SDs for normally distributed data; medians with IQRs for skewed data.
+- Bayesian analyses accepted but must include prior justification and sensitivity analysis.
+- Statistical software and version must be identified in Methods.
+
+---
+
+## Figures
+
+- **Maximum 5 figures/tables combined** — plan carefully
+- **Resolution**: 300 DPI minimum (600 DPI for line art)
+- **Format**: EPS, PDF, or TIFF preferred
+- **Color**: Free for online; print charges may apply
+- **Supplementary material**: Unlimited; include as eSupplement (eTables, eFigures, eMethods)
+- **Figure panels**: Label A, B, C; legends must be self-explanatory
+- **CONSORT/STARD flow**: counts as one figure
+
+---
+
+## Common Rejection Reasons
+
+1. **Insufficient novelty for general readership** — JAMA expects findings relevant across specialties; narrow subspecialty findings should go to JAMA Network journals
+2. **Missing Key Points box** — required at submission; auto-reject without it
+3. **Underpowered study** — JAMA rarely accepts pilot studies or small single-center work
+4. **Inadequate comparator** — clinical studies need meaningful control groups
+5. **Overclaiming** — editors are sensitive to causal language in observational studies
+6. **Statistical issues** — dedicated statistical editors flag problems at review; common: missing multiplicity adjustment, no sample size justification
+7. **AI studies without clinical endpoint** — technical AI papers should go to JAMA Network Open or specialty journals
+
+---
+
+## Cover Letter
+
+Must include:
+- Statement of novelty (1-2 sentences: what this adds beyond existing literature)
+- Statement that manuscript is not under consideration elsewhere
+- Statement that all authors approved the final version
+- Disclosure of any related manuscripts (submitted or in press)
+- Suggested and opposed reviewers (optional but recommended)
+
+---
+
+## Author Guidelines URL
+
+https://jamanetwork.com/journals/jama/pages/instructions-for-authors
+
+---
+
+## JAMA Network Transfer
+
+If rejected from JAMA, authors can transfer to JAMA Network specialty journals without reformatting:
+- **JAMA Internal Medicine** — internal medicine focus
+- **JAMA Surgery** — surgical studies
+- **JAMA Network Open** — all fields, multidisciplinary OA (most realistic for AI/radiology)
+- **JAMA Oncology**, **JAMA Cardiology**, **JAMA Neurology**, etc.
+
+Transfer preserves reviews. Editors of receiving journals make independent decisions.
+
+---
+
+## Positioning
+
+JAMA is appropriate when:
+- Large RCT or prospective cohort (N > 1000 preferred) with clinical endpoint
+- Practice-changing finding with broad relevance beyond one specialty
+- Public health or health policy implications
+- Diagnostic accuracy study with clear clinical decision impact
+
+Not appropriate for: small retrospective studies, technical AI methodology without clinical validation, narrow subspecialty findings (use JAMA Network journals instead).
+
+---
+
+## AI Writing Disclosure Policy
+- **Requirement level:** Required
+- **Permitted scope:** Language editing only — AI/LLM tools may be used for editing, grammar, and language improvement but cannot be listed as authors; AI must not generate scientific content, data analysis, or conclusions; authors bear full responsibility for all content including any AI-assisted text
+- **Disclosure location:** Methods + Cover letter — describe the AI tool name, version, and how it was used in the Methods section; also disclose in the cover letter; ICMJE-compliant disclosure required
+- **AI-generated images:** Discouraged — submission and publication of clinical images created by AI tools is discouraged unless part of formal research design or methods; if used, authors must provide a clear description of the content created and the AI tool name, version, and manufacturer; AI-generated or AI-manipulated images must be disclosed; fabrication/falsification policies apply (JAMA editorial 2024; confirmed Apr 2026)
+- **Policy URL:** https://jamanetwork.com/journals/jama/pages/instructions-for-authors#702720037

package/skills/write-paper/references/journal_profiles/JAMA_Network_Open.md

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+# Journal Profile: JAMA Network Open
+
+## Journal Identity
+
+- **Full name**: JAMA Network Open
+- **Abbreviation**: JAMA Netw Open
+- **Publisher**: American Medical Association (AMA)
+- **ISSN**: 2574-3805
+- **Frequency**: Continuous online publication (daily)
+- **Impact Factor**: ~13.8 (JCR 2023), ranked among top general medical journals
+- **Open Access**: Full OA (APC ~$3,500; waiver available for LMIC)
+- **Acceptance rate**: ~15-20% for Original Investigations
+- **Peer review**: Single-blind; statistical editor review on accepted manuscripts
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures/Tables |
+|------|----------------|----------|------------|----------------|
+| Original Investigation | 3000 words | 350 words (structured) | 50 | 5 |
+| Research Letter | 600 words | None | 6 | 1 |
+| Systematic Review & Meta-Analysis | 3500 words | 350 words (structured) | 75 | 5 |
+| Invited Commentary | 1000 words | None | 10 | 1 |
+| Diagnostic/Prognostic Study | 3000 words | 350 words (structured) | 50 | 5 |
+
+Word counts exclude abstract, references, tables, and figure legends.
+
+---
+
+## Abstract Requirements
+
+**Structured abstract, 350 words maximum:**
+
+```
+Importance: [Clinical significance, public health impact, knowledge gap]
+Objective: [Specific study aim — 1 sentence]
+Design, Setting, and Participants: [Study design, setting, eligibility criteria,
+    dates of data collection, analysis dates, follow-up duration]
+Exposure(s) [or Intervention(s)]: [Description of exposures/interventions]
+Main Outcomes and Measures: [Primary and secondary outcomes prespecified]
+Results: [Number enrolled/analyzed, demographic summary (age, sex),
+    primary results with effect sizes, 95% CIs, and exact P values]
+Conclusions and Relevance: [Main conclusion — 1-2 sentences;
+    clinical/public health relevance]
+```
+
+**Critical**: Follows JAMA Network 7-heading format. "Importance" is the first heading and the first thing editors evaluate. Include "Analysis dates" in Design heading (unique JAMA Network requirement since 2023).
+
+---
+
+## Required Sections (Original Investigation)
+
+### 1. Key Points Box
+
+Required at submission (placed before abstract). Three components:
+
+- **Question**: One sentence framing the research question.
+- **Findings**: One sentence with the main quantitative result (effect size + CI).
+- **Meaning**: One sentence stating clinical or public health relevance.
+
+### 2. Body Sections
+
+1. **Introduction** — brief (2-3 paragraphs); end with explicit study objective
+2. **Methods**
+   - Ethics: IRB approval with institution name + approval number; informed consent
+   - Study Design and Participants: inclusion/exclusion, recruitment dates, analysis dates
+   - Exposures or Interventions
+   - Outcomes: primary and secondary clearly defined a priori
+   - Statistical Analysis: software, tests, sample size justification, handling of missing data, sensitivity analyses
+3. **Results** — begin with participant flow and baseline characteristics table
+4. **Discussion** — begin with key findings summary; include Limitations subsection
+5. **Conclusions** — brief (1-2 sentences, matching abstract conclusion)
+
+### 3. Article Information
+
+- Author affiliations, corresponding author email
+- Author contributions (CRediT format accepted)
+- ICMJE conflict of interest forms from all authors
+- Funding/support and role of funder
+- Data sharing statement (required)
+
+---
+
+## Statistical Reporting
+
+- Report exact P values to 2 decimal places (e.g., P = .03); use P < .001 below that threshold.
+- 2-sided significance threshold stated (typically alpha = .05).
+- 95% CI required for all primary and key secondary outcomes.
+- Effect sizes with units (absolute risk difference, relative risk, hazard ratio, odds ratio).
+- For diagnostic accuracy: sensitivity, specificity, AUC with 95% CI; calibration reported.
+- Sample size justification in Methods (power calculation with assumptions).
+- Multiple comparisons: pre-specify primary outcome; use Bonferroni or similar correction, or declare secondary analyses as exploratory.
+- Missing data: describe mechanism (MCAR/MAR/MNAR) and handling approach.
+- Sensitivity analyses required for key assumptions.
+- Statistical software and version identified in Methods.
+- For AI/ML studies: internal and external validation; report discrimination and calibration.
+
+---
+
+## Figures
+
+- **Maximum 5 figures/tables combined** — plan carefully
+- **Resolution**: 300 DPI minimum (600 DPI for line art)
+- **Format**: EPS, PDF, or TIFF preferred; PowerPoint accepted
+- **Color**: Free (online-only journal)
+- **Supplementary material**: Unlimited eSupplement (eTables, eFigures, eMethods, eResults)
+- **Figure panels**: Label A, B, C; legends must be self-explanatory
+- **CONSORT/STARD/PRISMA flow**: counts as one figure
+- **Reporting checklist**: Upload completed checklist (STROBE, CONSORT, PRISMA, STARD, etc.)
+
+---
+
+## Common Rejection Reasons
+
+1. **Lack of novelty or clinical relevance** — findings must advance knowledge meaningfully
+2. **Missing Key Points box** — required at submission; technical reject without it
+3. **Inadequate methodology for study type** — wrong statistical approach, selection bias not addressed
+4. **No reporting checklist** — EQUATOR network guidelines strictly enforced
+5. **Overclaiming causality** — observational studies must use appropriate hedging language
+6. **Insufficient sample size without justification** — power calculation expected
+7. **AI studies without clinical validation** — must show clinical utility, not just technical performance
+
+---
+
+## Cover Letter
+
+Must include:
+- Statement of novelty (1-2 sentences: what this adds)
+- Statement that manuscript is not under consideration elsewhere
+- All authors approved the final version
+- Disclosure of related submitted/published manuscripts
+- AI tool disclosure (if used for writing/editing)
+- Suggested and opposed reviewers (optional)
+
+---
+
+## AI Writing Disclosure Policy
+- **Requirement level:** Required (Moderate)
+- **Permitted scope:** Language editing only — AI/LLM tools may be used for editing, grammar, and language improvement; AI must not generate scientific content, data analysis, or conclusions; AI cannot be listed as authors; authors bear full responsibility for all content
+- **Disclosure location:** Methods + Cover letter — describe the AI tool name, version, and specific use in the Methods section; also disclose in cover letter; ICMJE-compliant disclosure required
+- **AI-generated images:** Discouraged — AI-generated or AI-manipulated images must be disclosed; fabrication/falsification policies apply; if used as part of research design, provide full description of tool and process
+- **Policy URL:** https://jamanetwork.com/journals/jamanetworkopen/pages/instructions-for-authors
+
+---
+
+## Author Guidelines URL
+
+https://jamanetwork.com/journals/jamanetworkopen/pages/instructions-for-authors
+
+---
+
+## Positioning
+
+| Feature | JAMA Netw Open | JAMA | BMJ Open | PLOS Medicine |
+|---------|---------------|------|----------|---------------|
+| IF | ~13.8 | ~120 | ~3.0 | ~10.5 |
+| OA model | Full OA | Hybrid | Full OA | Full OA |
+| APC | ~$3,500 | ~$5,000 (optional) | ~$2,590 | ~$3,000 |
+| Abstract style | 7-heading (JAMA format) | 7-heading | Structured (varied) | Structured (varied) |
+| Acceptance rate | ~15-20% | ~5% | ~25% | ~10% |
+| Unique feature | Broadest JAMA Network scope | Highest prestige | High acceptance | Global health focus |
+| AI studies | Strong fit | Only practice-changing | Acceptable | If policy-relevant |
+
+JAMA Network Open is appropriate when:
+- Well-designed study with clinical relevance across medicine
+- Diagnostic accuracy or AI study with clinical endpoint validation
+- Systematic review or meta-analysis on a general medical topic
+- Study too specialized for JAMA but too general for specialty journals
+- Transferred from JAMA or JAMA specialty journal
+
+Not appropriate for: pure technical AI methodology, studies without clinical/public health relevance, case reports, very small pilot studies without justification.