medsci-skills 4.1.0

package/skills/write-paper/references/journal_profiles/NEJM.md

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+# Journal Profile: NEJM
+
+## Journal Identity
+
+- **Full name**: The New England Journal of Medicine
+- **Abbreviation**: NEJM, N Engl J Med
+- **Publisher**: Massachusetts Medical Society
+- **ISSN**: 0028-4793 (print), 1533-4406 (online)
+- **Frequency**: Weekly (52 issues/year)
+- **Impact Factor**: ~176 (JCR 2023), ranked 1st among general medical journals
+- **Open Access**: Hybrid (selected articles OA; most subscription-based)
+- **Acceptance rate**: ~5% for Original Articles
+- **Peer review**: Single-blind; dedicated statistical review for all manuscripts
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures/Tables |
+|------|----------------|----------|------------|----------------|
+| Original Article | 2700 words | 250 words (structured) | 40 | 4 |
+| Special Article | 2700 words | 250 words (unstructured) | 40 | 4 |
+| Review Article | 3500 words | 250 words (unstructured) | 100 | 5 |
+| Case Records (MGH) | Commissioned | N/A | 30 | 6 |
+| Clinical Practice | Commissioned | None | 40 | 3 |
+| Brief Report | 1500 words | 150 words | 15 | 2 |
+| Correspondence | 175 words | None | 5 | 1 |
+
+Word counts exclude abstract, references, tables, and figure legends.
+
+---
+
+## Abstract Requirements
+
+**Structured abstract, 250 words maximum (Original Articles):**
+
+```
+Background: [Context and knowledge gap — why this study was needed]
+Methods: [Study design, setting, participants, interventions, primary outcome]
+Results: [Key findings with numerical results, effect sizes, CIs, P values]
+Conclusions: [Main conclusion — 1-2 sentences directly answering the question]
+```
+
+**Critical**: NEJM uses a 4-heading structured abstract (Background, Methods, Results, Conclusions). The abstract must stand alone as a complete summary. ClinicalTrials.gov registration number required at end of abstract for trials.
+
+---
+
+## Required Sections (Original Article)
+
+1. **Introduction** — brief (2-3 short paragraphs); state the gap and end with the study objective
+2. **Methods**
+   - Ethics: IRB/ethics committee approval statement
+   - Study design and oversight: registration number, funding source, role of funder
+   - Participants: eligibility criteria, enrollment dates
+   - Interventions or exposures
+   - Outcomes: primary endpoint clearly stated
+   - Statistical analysis: prespecified plan, sample size rationale
+3. **Results** — begin with enrollment/demographics; report primary endpoint first
+4. **Discussion** — concise (4 paragraphs max); start with key findings, address limitations explicitly
+
+**Note**: NEJM does not use a separate "Conclusions" heading in the body. The final paragraph of Discussion serves as the conclusion.
+
+---
+
+## Statistical Reporting
+
+NEJM has exceptionally rigorous statistical standards:
+- Report exact P values (two-sided) to 2 decimal places; use P < 0.001 below that threshold.
+- 95% CI mandatory for primary and key secondary outcomes.
+- Hazard ratios, odds ratios, relative risks with CIs.
+- Absolute risk differences and number needed to treat (NNT) for clinical trials.
+- Sample size calculation with assumptions (power, alpha, expected effect size, dropout rate).
+- Pre-specified primary outcome; secondary outcomes clearly labeled.
+- Interim analyses and stopping rules described.
+- For non-inferiority trials: margin justification required.
+- Subgroup analyses: pre-specified; present with forest plot and interaction P values.
+- Missing data handling explicitly described (multiple imputation preferred).
+- Statistical software and version stated in Methods.
+
+---
+
+## Figures
+
+- **Maximum 4 figures/tables combined** — extremely limited; plan carefully
+- **Resolution**: 300 DPI minimum
+- **Format**: EPS, TIFF, or PDF for figures; editable (Word) for tables
+- **Color**: Free online; authors may be charged for print color
+- **Supplementary Appendix**: Unlimited eFigures, eTables, eMethods; published online-only
+- **CONSORT/study flow**: counts as one figure
+- **Figure quality**: Professional quality expected; NEJM may redraw accepted figures
+
+---
+
+## Common Rejection Reasons
+
+1. **Insufficient sample size or clinical impact** — NEJM expects large, definitive trials (typically N > 1000) or landmark observational studies
+2. **Narrow specialty focus** — must have broad relevance to general medical practice
+3. **Incremental findings** — results must be practice-changing, not confirmatory
+4. **Methodological concerns** — inadequate randomization, high dropout, or missing pre-registration for trials
+5. **Overclaiming** — causal language in observational studies; overgeneralization
+6. **Word count violations** — NEJM has among the strictest limits (2700 words); excess length is immediate concern
+
+---
+
+## Cover Letter
+
+Must include:
+- Brief statement of what the study adds (1-2 sentences)
+- Confirmation of exclusivity (not under consideration elsewhere)
+- Trial registration number (if applicable)
+- Disclosure of related published or submitted manuscripts
+- Suggested reviewers (optional)
+- Any potential conflicts of interest
+
+---
+
+## AI Writing Disclosure Policy
+- **Requirement level:** Required
+- **Permitted scope:** Language editing only — AI/LLM tools may be used for grammar and language editing; AI cannot generate scientific content, interpret data, or draw conclusions; AI tools cannot be listed as authors
+- **Disclosure location:** Methods — describe the AI tool name, version, and how it was used
+- **AI-generated images:** Not permitted — AI-generated clinical images, pathology, or radiology images are not allowed
+- **Policy URL:** https://www.nejm.org/author-center/new-manuscripts
+
+---
+
+## Author Guidelines URL
+
+https://www.nejm.org/author-center/new-manuscripts
+
+---
+
+## Positioning
+
+| Feature | NEJM | The Lancet | JAMA |
+|---------|------|-----------|------|
+| IF | ~176 | ~169 | ~120 |
+| Abstract style | 4-heading structured | Unstructured (300 words) | 7-heading structured |
+| Word limit (Original) | 2700 | 3500 | 3000 |
+| OA model | Hybrid | Hybrid | Hybrid |
+| Unique feature | Strictest word limit, clinical focus | Global health strength | Key Points box |
+| AI/radiology | Rare, only practice-changing | Occasional | Via JAMA Network |
+
+NEJM is appropriate when:
+- Large RCT with unambiguous clinical endpoint (mortality, major morbidity)
+- Practice-changing finding with immediate impact on patient care
+- Landmark epidemiological study with public health implications
+- Novel therapeutic approved or likely to change guidelines
+
+Not appropriate for: small studies, technical methodology papers, AI without clinical validation, narrow subspecialty findings, pilot/exploratory studies.

package/skills/write-paper/references/journal_profiles/Nature_Medicine.md

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+# Journal Profile: Nature Medicine
+
+## Journal Identity
+
+- **Full name**: Nature Medicine
+- **Abbreviation**: Nat Med
+- **Publisher**: Springer Nature
+- **ISSN**: 1078-8956 (print), 1546-170X (online)
+- **Frequency**: Monthly (12 issues/year)
+- **Impact Factor**: ~82 (JCR 2023), top-ranked translational medicine journal
+- **Open Access**: Hybrid (transformative agreements may cover OA at many institutions)
+- **Acceptance rate**: ~8% for Articles
+- **Peer review**: Single-blind; in-house editors with PhD/MD backgrounds handle triage
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures |
+|------|----------------|----------|------------|---------|
+| Article | No strict limit (typically 3000-5000) | 150 words (unstructured) | 50 | 8 |
+| Brief Communication | 1500 words | 3 sentences (unstructured) | 20 | 4 |
+| Review | No strict limit | 150 words | No limit | No limit |
+| Analysis | 3000 words | 150 words | 50 | 6 |
+| Correspondence | 500 words | None | 10 | 1 |
+| Resource | No strict limit | 150 words | 50 | 8 |
+
+Word counts include Methods summary in main text. Detailed Methods go in Online Methods.
+
+---
+
+## Abstract Requirements
+
+**Unstructured abstract, 150 words maximum:**
+
+A single paragraph, no headings. Must include:
+- Study rationale (1 sentence)
+- What was done (design, N, key method)
+- Main findings (primary result with effect size)
+- Significance (1 sentence: why this matters)
+
+**Critical**: Nature Medicine abstracts are very short (150 words). Every word must count. No background preamble — start with the gap or objective.
+
+---
+
+## Required Journal-Specific Elements
+
+### 1. Online Methods
+
+Detailed methods go in the Online Methods section (separate from main text). This section has no word limit and should include:
+- Study design and participants
+- Detailed protocols
+- Statistical analysis
+- Code availability
+- Data availability
+
+The main-text Methods summary is typically 1-2 paragraphs referencing the Online Methods.
+
+### 2. Reporting Summary
+
+Nature Research Reporting Summary required at submission. Covers:
+- Study design, statistical methods, data availability
+- Life sciences: ethics, clinical trial registration
+- Software and code availability
+
+### 3. Data Availability Statement
+
+Mandatory. Must specify: what data, where deposited, accession codes, access conditions.
+
+### 4. Code Availability Statement
+
+Mandatory if computational methods are used. Must specify: repository URL, version, DOI.
+
+---
+
+## Required Sections (Article)
+
+1. **Introduction** — 2-3 paragraphs; concise, end with study aims
+2. **Results** — presented first (before Methods in main text); subheadings encouraged
+3. **Discussion** — 3-4 paragraphs; limitations discussed within
+4. **Methods** (summary in main text) — brief overview referencing Online Methods
+5. **Online Methods** — full methodological detail (no word limit)
+6. **References**
+7. **Acknowledgements**
+8. **Author Contributions** — specific per-author contributions
+9. **Competing Interests** — or "The authors declare no competing interests"
+10. **Extended Data** — up to 10 figures/tables, peer-reviewed (unlike Supplementary)
+
+**Note**: Nature Medicine uses Results-before-Methods order in the main text.
+
+---
+
+## Statistical Reporting
+
+Nature Medicine follows Nature Research statistical guidelines:
+- Report exact P values where possible; state as P < 0.001 if below that threshold.
+- 95% CI for all primary outcomes.
+- Effect sizes required; do not report P values alone.
+- For multiple comparisons: describe correction method (Bonferroni, FDR, etc.) or justify if none applied.
+- Sample sizes and how they were determined must be stated (power analysis preferred).
+- For each statistical test: state the test name, whether one-tailed or two-tailed, and the exact value of N.
+- Data distribution: state whether normality was tested and which test was used.
+- Box plots: define center line, box limits, whiskers, and individual data points shown.
+- Source data for all figures must be provided.
+- Statistical software and version must be identified in Methods.
+
+---
+
+## Figures
+
+- **Maximum 8 figures** for Articles, 4 for Brief Communications
+- **Extended Data**: up to 10 additional figures/tables (peer-reviewed, unlike Supplementary)
+- **Supplementary Information**: unlimited (not peer-reviewed, for completeness)
+- **Resolution**: 300 DPI (bitmap), vector preferred (PDF, EPS, AI)
+- **Figure size**: single column (88 mm) or double column (180 mm)
+- **Color**: free, no charges
+- **Panels**: Label a, b, c (lowercase); scale bars required for microscopy/imaging
+- **Source data**: Raw data for each figure must be provided as Source Data files
+
+---
+
+## Common Rejection Reasons
+
+1. **Insufficient translational impact** — Nature Medicine requires clear bridge from bench to bedside; pure methodology papers rejected
+2. **Lack of clinical validation** — AI/computational studies need clinical or at least large retrospective clinical cohort validation
+3. **Single-center without external validation** — multi-site strongly preferred
+4. **Abstract too long** — 150-word limit is strictly enforced
+5. **Methods in wrong location** — main text should have Results before Methods summary
+6. **Missing data/code availability** — mandatory for all computational studies
+7. **Overclaiming causation** — editors flag causal language in observational designs
+8. **Incremental advance** — must demonstrate substantial advance over existing methods/knowledge
+
+---
+
+## Cover Letter
+
+Nature Medicine cover letters are read carefully by editors. Must include:
+- Why this study is important for Nature Medicine's readership (translational impact)
+- Key finding in 1-2 sentences
+- Why the study is timely
+- Statement of originality (not published/submitted elsewhere)
+- Suggested reviewers (3-5, with brief justification for each)
+- Opposed reviewers (optional)
+
+---
+
+## Author Guidelines URL
+
+https://www.nature.com/nm/submission-guidelines
+
+---
+
+## Positioning
+
+Nature Medicine is appropriate when:
+- AI/ML study with clinical validation on large, diverse patient cohort
+- Multi-center prospective study with clinical endpoint
+- Novel biomarker or diagnostic with translational path
+- First-in-human results for novel therapeutic approach
+- Large-scale genomic/proteomic study with disease mechanism insight
+
+Not appropriate for: pure technical methodology (use Nature Methods or Nature Machine Intelligence), small retrospective studies, incremental improvements to existing methods, studies without clinical relevance.
+
+---
+
+## Brief Communication vs Article
+
+| Dimension | Article | Brief Communication |
+|-----------|---------|-------------------|
+| Scope | Full study, multiple analyses | Single key finding |
+| Abstract | 150 words | 3 sentences |
+| Body | ~3000-5000 words | 1500 words |
+| Figures | 8 | 4 |
+| Use when | Comprehensive study | Striking result, rapid publication |
+
+---
+
+## AI Writing Disclosure Policy
+- **Requirement level:** Required
+- **Permitted scope:** Language editing only — AI/LLM tools (e.g., ChatGPT, Claude) may assist with language, grammar, and readability but cannot be listed as authors; AI must not generate scientific content, interpret results, or draw conclusions; authors bear full responsibility for accuracy and integrity
+- **Disclosure location:** Methods — describe the AI tool name, version, and how it was used in the Methods section; Nature Portfolio requires disclosure in the manuscript body, not just a cover letter; also captured in the Nature Research Reporting Summary
+- **AI-generated images:** Banned — AI-generated images are not permitted in published figures; any image manipulation must follow Nature's image integrity policies; computational visualizations from AI research tools must be clearly labeled
+- **Policy URL:** https://www.nature.com/nature-portfolio/editorial-policies/ai

package/skills/write-paper/references/journal_profiles/Neuroradiology.md

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+# Journal Profile: Neuroradiology
+
+## Journal Identity
+
+- **Full name**: Neuroradiology
+- **Abbreviation**: Neuroradiology
+- **Publisher**: Springer Nature (European Society of Neuroradiology, ESNR)
+- **ISSN**: 0028-3940 (print), 1432-1920 (online)
+- **Frequency**: Monthly (12 issues/year)
+- **Impact Factor**: ~3.4 (JCR 2023)
+- **Open Access**: Hybrid (Springer transformative agreements may cover OA)
+- **Acceptance rate**: ~30%
+- **Peer review**: Single-blind; typically 2 reviewers
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures/Tables |
+|------|----------------|----------|------------|----------------|
+| Original Article | 3500 words | 250 words (structured) | 35 | 6 |
+| Review Article | 5000 words | 250 words | 60 | 8 |
+| Technical Note | 2000 words | 150 words (unstructured) | 15 | 4 |
+| Diagnostic Neuroradiology | 1500 words | 150 words | 10 | 6 |
+| Interventional Neuroradiology | 3000 words | 250 words (structured) | 30 | 6 |
+| Letter to the Editor | 500 words | None | 5 | 1 |
+| Pictorial Review | 3000 words | 200 words | 20 | 12 |
+
+Word counts exclude abstract, references, tables, and figure legends.
+
+---
+
+## Abstract Requirements
+
+**Structured abstract for Original Articles and Interventional, 250 words maximum:**
+
+```
+Purpose: [Study aim — 1-2 sentences]
+Methods: [Design, population, imaging protocol, analysis]
+Results: [Key findings with statistics]
+Conclusion: [Main conclusion — 1-2 sentences]
+```
+
+**Unstructured abstract for Technical Notes and Diagnostic Neuroradiology, 150 words.**
+
+---
+
+## Required Sections (Original Article)
+
+1. **Introduction** — clinical context, gap, purpose (2-3 paragraphs)
+2. **Methods** (Springer uses "Methods" not "Materials and Methods")
+   - Study Design: IRB approval, retrospective/prospective
+   - Patient Population: inclusion/exclusion, time period
+   - Imaging Protocol: scanner model, sequence parameters (critical for neuroradiology)
+   - Image Analysis: readers, blinding, measurement methods
+   - Statistical Analysis: software, tests
+3. **Results** — demographics, imaging findings, quantitative results
+4. **Discussion** — comparison with literature, pathophysiological implications, limitations
+5. **Conclusion** — brief (1-2 sentences)
+
+---
+
+## Statistical Reporting
+
+- Report exact p-values; use p < 0.001 below that threshold.
+- 95% CI for primary outcomes.
+- For diagnostic accuracy: sensitivity, specificity, AUC with 95% CI.
+- Inter-reader agreement: ICC with model/type specification, or kappa with weighting scheme.
+- For volumetric measurements: Bland-Altman analysis with limits of agreement.
+- Multiple comparisons: Bonferroni or false discovery rate correction.
+- Statistical software and version must be identified.
+
+---
+
+## Neuroradiology-Specific Requirements
+
+### Imaging Protocol Detail
+
+Neuroradiology expects detailed MRI/CT protocol reporting:
+- Scanner manufacturer, model, field strength
+- Sequence names and key parameters (TR, TE, flip angle, slice thickness, matrix, FOV)
+- Contrast agent: name, dose, injection rate, delay
+- Post-processing: software, version, reconstruction parameters
+
+### Anatomy and Pathology Terminology
+
+Use standardized neuroradiology terminology:
+- Stroke: use ASPECTS, mRS, NIHSS
+- Tumors: WHO classification with molecular markers
+- Vascular: use standard aneurysm measurement conventions
+- Spine: use standard nomenclature for disc herniation (protrusion, extrusion, sequestration)
+
+---
+
+## Figures
+
+- **Maximum 6 figures/tables** for original articles; **12 for Pictorial Reviews**
+- **Resolution**: 300 DPI minimum
+- **Format**: TIFF, EPS, JPEG (high quality)
+- **Color**: Free online; Springer handles conversion
+- **Neuroimaging conventions**: window/level should match clinical display; annotations with arrows/arrowheads; anatomical orientation labeled
+
+---
+
+## Common Rejection Reasons
+
+1. **Insufficient imaging protocol detail** — neuroradiology readers expect MRI sequence-level specificity
+2. **Small single-center retrospective** without novelty — Neuroradiology accepts more readily than AJNR but still needs contribution
+3. **Missing inter-reader agreement** — for studies with subjective measurements
+4. **Overlapping scope with AJNR** — if the study has a stronger North American angle, consider AJNR first
+5. **Diagnostic Neuroradiology cases** too common — must be genuinely educational or rare
+
+---
+
+## Cover Letter
+
+Should include:
+- Relevance to European neuroradiology practice
+- Brief summary of key findings
+- Statement of originality
+- Suggested reviewers with neuroradiology expertise
+
+---
+
+## Author Guidelines URL
+
+https://www.springer.com/journal/234/submission-guidelines
+
+---
+
+## Positioning
+
+Neuroradiology is appropriate when:
+- Brain, spine, or head/neck imaging study with clinical relevance
+- AI applied to neuroimaging with diagnostic validation
+- Interventional neuroradiology outcome study (thrombectomy, embolization, stenting)
+- Advanced imaging technique (perfusion, diffusion, spectroscopy) in neurological disease
+- Pictorial reviews of neuroradiology topics
+
+Not appropriate for: body imaging, non-neurological applications, pure methodology without neuroimaging data.
+
+---
+
+## Differentiation from AJNR
+
+| Dimension | Neuroradiology | AJNR |
+|-----------|---------------|------|
+| Society | ESNR (European) | ASNR (American) |
+| Impact factor | ~3.4 | ~3.5 |
+| Scope | Diagnostic + interventional neuro | Diagnostic + interventional + spine |
+| Geography | European/international | North American/international |
+| Case reports | "Diagnostic Neuroradiology" category | "Case Report" (limited acceptance) |
+| Pictorial reviews | Accepted (up to 12 figures) | Less common format |

package/skills/write-paper/references/journal_profiles/Nutrition_Metabolism_and_Cardiovascular_Diseases.md

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+# Journal Profile: Nutrition, Metabolism and Cardiovascular Diseases (NMCD)
+
+## Journal Identity
+
+- **Full name**: Nutrition, Metabolism and Cardiovascular Diseases
+- **Abbreviation**: Nutr Metab Cardiovasc Dis
+- **Publisher**: Elsevier
+- **ISSN**: 0939-4753 (print) / 1590-3729 (online)
+- **Frequency**: Monthly
+- **Impact Factor**: ~3.9 (recent JCR; verify at submission)
+- **Open Access**: Hybrid — APC USD 3,560 for gold open access; subscription model available
+- **Peer review**: Single-blind; statistical review where methodology is heavy
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures/Tables |
+|------|----------------|----------|------------|----------------|
+| Original Article | 4,000 words | 250 (structured) | 60 max | 6 max |
+| Systematic Review / Meta-analysis | 6,000 words | 250 (structured) | 120 max | 8 max |
+| Viewpoint / Short Review | 3,000 words | 200 (unstructured) | 50 max | 4 max |
+| Institutional Review | as Original | as Original | as Original | as Original |
+| Short Communication | 1,500 words | 200 | 20 max | 2 max |
+| Letter to the Editor | 800 words | none | 10 max | 1 max |
+
+Word counts exclude abstract, references, tables, and figure legends.
+
+---
+
+## Abstract Requirements
+
+**Structured abstract for Original Article, 250 words maximum, with 3 headings:**
+
+```
+Background and Aims: [Context + specific research question or hypothesis]
+Methods and Results: [Design, setting, population, exposures, outcomes, statistical approach + primary results with effect sizes, 95% CIs, P values]
+Conclusion: [Direct answer to Aims with clinical or public-health implication]
+```
+
+The merged "Methods and Results" heading is a NMCD-specific stylistic choice. Reviewers and the editorial system check this heading exactly.
+
+---
+
+## Required Journal-Specific Elements
+
+### 1. Graphical Abstract (optional)
+
+Encouraged for Original Articles and Meta-analyses; uploaded as a separate file at submission.
+
+### 2. Article Information
+
+- Author affiliations with department, institution, city, country
+- Corresponding author full contact details
+- Funding statement with grant identifiers
+- Disclosures: per-author ICMJE conflicts of interest
+- Data availability statement
+- Ethical statement (IRB or equivalent + informed consent)
+
+---
+
+## Required Sections (Original Article)
+
+1. **Introduction** — 2–3 paragraphs ending with clear aims
+2. **Methods**
+   - Ethics approval with body name
+   - Study design and setting
+   - Participants and eligibility
+   - Variables / definitions (nutrition exposures and metabolic measures defined explicitly)
+   - Outcomes (primary, secondary, exploratory clearly distinguished)
+   - Statistical analysis with software and versions
+3. **Results** — STROBE/CONSORT flow; primary outcome before secondary
+4. **Discussion** — Strengths and Limitations sub-paragraphs; conclude with mechanistic and clinical/public-health implications
+5. **Conclusion** — brief; avoid overclaiming
+
+---
+
+## Statistical Reporting
+
+- Exact P values to 3 decimal places (P < 0.001 below threshold)
+- 95% CI for all primary effect estimates
+- Effect sizes appropriate to design (HR, OR, mean difference, absolute risk difference)
+- Proportional-hazards assumption check (Schoenfeld) when Cox is used
+- For nutrition exposures: report measurement method (FFQ, 24h recall, weighed records) with validation reference
+- For metabolic biomarkers: report assay, intra- and inter-assay CV, and calibration source
+- Sensitivity analyses for major analytic choices (missing data, alternative cutpoints, exposure misclassification)
+- Software and version reported
+
+---
+
+## Figures
+
+- **Maximum 6 figures/tables combined** for Original Article
+- Resolution: 300 DPI minimum
+- Format: TIFF, EPS, PDF, or high-quality PNG
+- Color: encouraged
+- Supplementary material: online-only supplement permitted
+
+---
+
+## Common Rejection Reasons
+
+1. **Insufficient nutrition–metabolism–cardiovascular linkage** — manuscripts framed as pure cardiology or pure nutrition without the crossover axis are redirected
+2. **Single-center cohort without external comparison** — population-based or multicenter preferred
+3. **Missing measurement-method detail for nutrition exposures** — methodology bar is high for dietary assessment
+4. **Overclaiming on observational data** — wide-CI estimates without exploratory qualifier
+5. **Abstract heading mismatch** — using Background/Methods/Results/Conclusions instead of Background and Aims/Methods and Results/Conclusion
+6. **AI policy non-compliance** — undisclosed AI use or AI listed as author
+7. **Reference style violations** — failing to follow numbered citation order with first-6-then-et-al rule
+
+---
+
+## Cover Letter
+
+Must include:
+- Brief statement of novelty and the nutrition–metabolism–CVD crossover relevance
+- Confirmation manuscript is not under consideration elsewhere
+- Confirmation all authors meet ICMJE criteria
+- Disclosure of related manuscripts (same cohort, same group)
+- Suggested reviewers (3–5; senior PI curates)
+- AI disclosure aligned with the in-manuscript declaration
+
+---
+
+## AI Writing Disclosure Policy
+
+- **Requirement level**: Required
+- **Disclosure template** (verbatim, immediately before references):
+  > "During the preparation of this work the author(s) used [NAME OF TOOL / SERVICE] in order to [REASON]. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication."
+- **Permitted scope**: AI/LLM tools may be used for language editing, structural review, and consistency checks; AI cannot be listed as author
+- **Disclosure location**: Dedicated declaration immediately before the references
+- **AI-generated images**: Elsevier policy prohibits AI generation or alteration of images
+- **Grammar/spell-check exception**: Basic grammar/spelling/punctuation tools need no declaration
+- **Policy URL**: https://www.elsevier.com/about/policies-and-standards/the-use-of-generative-ai-and-ai-assisted-technologies-in-writing-for-elsevier
+
+---
+
+## Submission Portal
+
+https://www.editorialmanager.com/nmcd
+
+---
+
+## Author Guidelines URL
+
+https://www.sciencedirect.com/journal/nutrition-metabolism-and-cardiovascular-diseases/publish/guide-for-authors
+
+---
+
+## Positioning
+
+| Criterion | NMCD | EJPC | JACC: Advances | Atherosclerosis |
+|-----------|------|------|----------------|------------------|
+| **Society** | independent (Elsevier) | ESC/EAPC | ACC | EAS-affiliated (Elsevier) |
+| **Impact Factor** | ~3.9 | ~8 | not indexed yet | ~5 |
+| **Open Access** | Hybrid | Hybrid | Full Gold OA | Hybrid |
+| **Geographic stance** | International | Europe-centric | Global | International (Europe-centric) |
+| **Primary framing** | Nutrition–metabolism–CVD crossover | Cardiovascular prevention | Cardiovascular broad | Atherosclerosis / lipid biology |
+| **Abstract first heading** | Background and Aims | Aims | Background | Background and Aims |
+| **Word cap (Original)** | 4,000 | 5,000 | 5,000 (incl. refs+legends) | varies |
+
+**Choose NMCD when:**
+- Nutrition exposure or metabolic intervention is integral to the exposure or interpretation
+- Mediterranean diet, MASLD, metabolic syndrome, or insulin-resistance pathway is the central narrative
+- Crossover audience (cardiology + nutrition + endocrinology) matters
+
+**Choose EJPC instead when:**
+- Primary prevention angle dominates over the nutrition crossover
+- ESC ecosystem reach matters more than the Elsevier cardio-metabolic platform
+
+**Choose JACC: Advances instead when:**
+- AHA-aligned framework application (e.g., CKM staging) is the central methodological contribution
+- ACC ecosystem and Full Gold OA matter
+
+**Choose Atherosclerosis instead when:**
+- Lipid or plaque biology is the dominant mechanistic axis
+- The contribution is more about vascular biology than nutrition/metabolic clustering
+
+---
+
+## Verification
+
+- **Source (compact harvest):** local private profile (2026-05-20 fetch from https://www.sciencedirect.com/journal/nutrition-metabolism-and-cardiovascular-diseases/publish/guide-for-authors)
+- **Source (detail authored):** based on harvested compact + Elsevier publisher-level AI policy + NMCD-specific abstract heading verbatim
+- **Date (promoted to public):** 2026-05-21
+- **Notes:** Verify APC and IF directly on the journal site at submission. Word limits sourced from compact harvest.