medsci-skills 4.1.0

package/skills/write-paper/references/journal_profiles/IEEE_TMI.md

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+# Journal Profile: IEEE Transactions on Medical Imaging (IEEE TMI)
+
+## Journal Identity
+
+- **Full name**: IEEE Transactions on Medical Imaging
+- **Abbreviation**: IEEE Trans Med Imaging
+- **Publisher**: IEEE (Institute of Electrical and Electronics Engineers)
+- **ISSN**: 0278-0062 (print), 1558-254X (online)
+- **Frequency**: Monthly (12 issues/year)
+- **Impact Factor**: ~10.6 (JCR 2023), top-ranked in medical imaging engineering
+- **Open Access**: Hybrid (IEEE OA option with APC ~$2,095)
+- **Acceptance rate**: ~20-25%
+- **Peer review**: Single-blind; associate editors assign 3+ expert reviewers
+
+## Manuscript Types and Page Limits
+
+| Type | Page Limit | Abstract | References |
+|------|-----------|----------|------------|
+| Regular Paper | 12 pages (IEEE 2-column) | 250 words | No strict limit |
+| Short Paper | 6 pages | 150 words | No strict limit |
+| Correspondence | 3 pages | 100 words | 15 |
+
+**Page limits include everything**: text, figures, tables, references. This is stricter than word-count journals — plan figure sizes carefully.
+
+**Overlength charges**: $175 per page beyond the limit (mandatory).
+
+---
+
+## Abstract Requirements
+
+**Unstructured abstract, 250 words maximum:**
+
+Single paragraph covering:
+- Problem statement and clinical relevance (1-2 sentences)
+- Proposed approach (2-3 sentences)
+- Key experimental results with metrics (2-3 sentences)
+- Conclusion/significance (1 sentence)
+
+---
+
+## Required Journal-Specific Elements
+
+### 1. IEEE Keywords
+
+Select from the IEEE controlled keyword taxonomy. Typically 5-8 keywords including:
+- Index Terms from IEEE Thesaurus
+- Common: "medical image analysis," "deep learning," "convolutional neural networks," "image segmentation," "computed tomography," "magnetic resonance imaging"
+
+### 2. IEEE Author Profile
+
+Each author needs an IEEE-format biography (2-3 sentences: degree, institution, research interests). Placed at the end of the paper with optional author photo.
+
+### 3. Acknowledgment Section
+
+Funding sources and grant numbers in a dedicated Acknowledgment section (before References).
+
+---
+
+## Required Sections (Regular Paper)
+
+1. **Introduction** — problem statement, literature review, contribution summary (typically bulleted list of contributions at end)
+2. **Related Work** — detailed comparison with prior approaches
+3. **Methods / Proposed Method**
+   - Mathematical formulation with equations
+   - Architecture description with diagram
+   - Training procedure: loss function, optimizer, hyperparameters
+   - Implementation details
+4. **Experiments**
+   - Datasets: description, split strategy, preprocessing
+   - Evaluation metrics
+   - Baseline methods
+   - Ablation study
+   - Computational complexity analysis
+5. **Results and Discussion** — can be combined or separate
+6. **Conclusion**
+7. **Acknowledgment**
+8. **References**
+9. **Author Biographies**
+
+---
+
+## Statistical Reporting
+
+IEEE TMI follows engineering/computing conventions:
+- Report metrics with mean and standard deviation across folds, runs, or subjects.
+- Statistical significance: paired t-test or Wilcoxon signed-rank between methods; report exact P values.
+- For segmentation: Dice, Hausdorff distance (HD95), average surface distance (ASD).
+- For detection: sensitivity at fixed false positive rates, FROC.
+- For classification: AUC, accuracy, sensitivity, specificity, F1.
+- Ablation table: systematically add/remove components with corresponding metric changes.
+- Computational cost: FLOPs, parameters, training time, inference time, GPU memory.
+- Cross-validation: report per-fold results or confidence intervals, not just mean.
+- Reproducibility: random seed, number of runs, hardware specification.
+- Software framework and version must be identified.
+
+---
+
+## Formatting
+
+### IEEE Two-Column Format
+
+- **Template**: Use `IEEEtran.cls` LaTeX class (mandatory for camera-ready)
+- **Font**: Times New Roman (auto in IEEEtran)
+- **Margins**: IEEE standard (auto in template)
+- **Equations**: Numbered sequentially; referenced as (1), (2), etc.
+- **Figures**: Fit within single column (3.5 in / 88 mm) or span both columns (7.16 in / 182 mm)
+- **Tables**: Same column/span rules as figures
+- **References**: IEEE abbreviated style (e.g., [1], [2])
+
+### Figure Requirements
+
+- **Resolution**: 300 DPI minimum (600 DPI for line art)
+- **Format**: PDF, EPS, or high-resolution PNG/TIFF
+- **Color**: Free for online; grayscale conversion should be legible
+- **Captions**: Below figures; brief but self-explanatory
+- **Size matters**: figures consume page budget — use multi-panel layouts efficiently
+
+---
+
+## Common Rejection Reasons
+
+1. **Page limit exceeded** — 12-page limit is strict; overlength papers are returned without review
+2. **Insufficient novelty** — applying existing deep learning to new dataset without methodological innovation
+3. **Unfair experimental comparison** — different training conditions between proposed and baseline methods
+4. **Missing ablation study** — IEEE TMI reviewers consistently require component-wise evaluation
+5. **Poor writing quality** — IEEE TMI has high standards for technical writing clarity
+6. **No comparison with recent methods** — must include methods from the last 2 years
+7. **Single dataset** — multi-dataset evaluation expected for generalizability
+8. **Conference paper overlap** — if extending a conference paper (MICCAI, ISBI), must clearly state and quantify the additional contribution (typically 30%+ new content)
+
+---
+
+## Cover Letter
+
+IEEE TMI does not require a formal cover letter but ScholarOne submission requires:
+- Manuscript type selection
+- Suggested reviewers (3-5 with affiliations and emails)
+- Statement of originality
+- If conference extension: explicit statement of what is new (with percentage estimate)
+
+---
+
+## Author Guidelines URL
+
+https://www.embs.org/tmi/authors/
+
+---
+
+## Conference-to-Journal Extension
+
+IEEE TMI commonly receives extended versions of MICCAI, ISBI, IPMI papers. Requirements:
+- At least 30% new content (experiments, methods, or analysis)
+- Must cite and explicitly compare with conference version
+- Reviewers assess the delta, not just the full paper
+- State clearly in cover letter and introduction what is new
+
+---
+
+## Positioning
+
+IEEE TMI is appropriate when:
+- Novel imaging algorithm with rigorous quantitative evaluation
+- New reconstruction, registration, or segmentation method with mathematical foundation
+- Multi-modal fusion or novel imaging physics-informed approach
+- Comprehensive benchmark study on medical imaging task
+- Conference paper extension with substantial new experiments/methods
+
+Not appropriate for: clinical outcome studies without technical contribution (use clinical journals), pure application of existing methods, papers without quantitative evaluation on medical data.
+
+---
+
+## Differentiation from Related Venues
+
+| Dimension | IEEE TMI | MedIA | IEEE JBHI |
+|-----------|---------|-------|-----------|
+| Format | 12-page IEEE 2-column | No page limit, Elsevier | 10-page IEEE 2-column |
+| Scope | Medical imaging methods | Medical image analysis methods | Health informatics (broader) |
+| Emphasis | Imaging + math rigor | Methods depth + ablation | EHR, wearables, signals + imaging |
+| LaTeX class | IEEEtran (mandatory) | elsarticle (preferred) | IEEEtran (mandatory) |
+| Typical length | Shorter, denser | Longer, more detailed | Shorter |

package/skills/write-paper/references/journal_profiles/INSI.md

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+# Journal Profile: Interventional Neuroradiology (INSI)
+
+## Basic Information
+
+- **Publisher:** SAGE Publications
+- **Society:** European Society of Minimally Invasive Neurological Therapy (ESMINT) / World Federation of Interventional and Therapeutic Neuroradiology (WFITN)
+- **Impact Factor:** ~2.5–3.0 (2023–2024)
+- **Scope:** Endovascular and minimally invasive neuroradiology; neurovascular interventions; stroke intervention; head/neck vascular procedures
+- **Open Access:** Optional (SAGE Choice)
+- **Language:** American English
+
+---
+
+## Scope — Covered Topics
+
+- Cerebral aneurysm treatment (coiling, stent-assisted coiling, flow diversion, WEB device)
+- Mechanical thrombectomy for acute ischemic stroke
+- Carotid and vertebral artery stenting
+- Cerebral arteriovenous malformation (AVM) embolization
+- Dural arteriovenous fistula (dAVF) embolization
+- Intracranial atherosclerosis treatment
+- Venous sinus stenting for idiopathic intracranial hypertension
+- Tumor embolization (head/neck, meningioma)
+- Spinal vascular interventions
+- Novel devices and techniques in neurointerventional radiology
+
+---
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | Figures | References |
+|------|----------------|----------|---------|------------|
+| Original Article | 3500 words | 250 words | 8 | 40 |
+| Review Article | 5000 words | 300 words | 10 | 60 |
+| Technical Note | 2000 words | 150 words | 6 | 20 |
+| Case Report | 2000 words | 200 words | 6 | 20 |
+| Letter | 600 words | None | 2 | 5 |
+
+---
+
+## Abstract Requirements
+
+**Structured abstract, 250 words:**
+
+```
+Background and Purpose: [Why this procedure/study is needed; clinical context]
+Methods: [Study design, patient population, procedural details, outcomes assessed]
+Results: [Technical success rate, clinical outcomes, complication rates with 95% CI,
+          follow-up duration]
+Conclusions: [Main conclusion; clinical implication]
+```
+
+---
+
+## Domain-Specific Outcome Measures
+
+### For Stroke/Thrombectomy Studies
+
+- **Recanalization:** mTICI (modified Treatment in Cerebral Infarction) scale — state score threshold for success (typically mTICI ≥ 2b)
+- **Clinical outcome at 90 days:** mRS (modified Rankin Scale) — good outcome = mRS 0–2
+- **Early neurological improvement:** NIHSS change at 24 hours
+- **Mortality at 90 days**
+- **Symptomatic intracranial hemorrhage (sICH):** ECASS II or SITS criteria — specify which
+
+### For Aneurysm Studies
+
+- **Technical success:** Complete coil/device deployment without procedure-related mortality or major stroke
+- **Aneurysm occlusion:** Raymond-Roy Occlusion Classification (RROC) or O'Kelly-Marotta (OKM) scale for flow diversion
+- **Procedure-related complications:** stroke, parent artery occlusion, aneurysm perforation, thromboembolic events
+- **Aneurysm recurrence:** Defined explicitly (e.g., recanalization requiring retreatment)
+- **Follow-up imaging:** DSA (gold standard) or MRA; state modality and timing
+
+### For General Neurointerventional Studies
+
+- **Technical success rate:** [Clearly define what constitutes technical success]
+- **Procedural complications:** Define minor (no permanent deficit) vs. major (permanent neurological deficit or death)
+- **Clinical outcomes:** Follow-up mRS or equivalent functional score
+- **Radiation exposure:** DAP (dose area product), fluoroscopy time (for technique comparison studies)
+- **Procedure time:** From femoral puncture to end of procedure
+
+---
+
+## Required Sections
+
+1. **Introduction** — Clinical background; why the specific technique/device/approach is being studied
+2. **Materials and Methods**
+   - Ethics: IRB number + consent (or exemption for retrospective studies)
+   - Patient population: Consecutive or selected? Selection criteria for treatment
+   - Procedural details: Describe technique in enough detail to be replicable; include specific devices/catheters/materials with brand names and catalog numbers for first-time techniques
+   - Outcome definitions: Define each outcome explicitly before reporting results
+   - Statistical analysis
+3. **Results**
+   - Patient baseline characteristics (Table 1)
+   - Technical outcomes (Table 2)
+   - Clinical outcomes at each follow-up time point
+   - Complications (ALL complications — report even if none: "No procedure-related complications occurred")
+4. **Discussion**
+5. **Conclusion**
+
+---
+
+## Common Complications to Always Address
+
+For any neurointerventional study, explicitly address these even if not observed:
+- Thromboembolic events (stroke, TIA)
+- Access site complications (hematoma, pseudoaneurysm, AV fistula)
+- Vessel perforation or rupture
+- Contrast reaction
+- Radiation injury (for prolonged procedures)
+- Device-specific complications (coil migration, stent misplacement)
+
+---
+
+## Statistical Requirements
+
+- Report 95% CI for all primary outcomes (especially rates/proportions)
+- Clopper-Pearson exact 95% CI for proportions (appropriate for small N)
+- Kaplan-Meier for time-to-event outcomes (recurrence, re-treatment)
+- For technique comparisons: appropriate parametric/non-parametric test with effect size
+- Report N analyzed at each follow-up time point (attrition matters)
+
+---
+
+## Figures for Neurointerventional Papers
+
+| Figure | Content |
+|--------|---------|
+| Figure 1 | Representative case — pre-procedure angiogram |
+| Figure 2 | Intra-procedure steps (guide catheter placement, device deployment) |
+| Figure 3 | Post-procedure result (immediate angiogram) |
+| Figure 4 | Follow-up angiogram or imaging |
+| Figure 5 | Outcome charts (bar chart of mRS distribution, OKM grades) |
+
+DSA images should be high-quality screen captures or exports from angiography workstation. Show projections that best demonstrate the finding (typically AP and lateral, or working projection for treatment).
+
+---
+
+## Common Rejection Reasons
+
+1. **Small single-center series** — INSI accepts these for novel techniques but sample size must be explicitly justified
+2. **Missing complication reporting** — every study must report all complications, including minor ones and access site issues
+3. **Undefined outcome measures** — define mTICI success threshold, mRS cutoff, and occlusion classification before reporting results
+4. **No follow-up imaging** — aneurysm studies without angiographic follow-up (minimum 6–12 months) are typically insufficient for original articles
+5. **Heterogeneous patient mix** — mixing ruptured and unruptured aneurysms without subgroup analysis is a common methodology concern
+6. **Operator experience not described** — for technique papers, describe center volume (procedures/year) and operator experience
+
+---
+
+## Author Guidelines URL
+
+https://journals.sagepub.com/author-instructions/INI
+
+---
+
+## Positioning
+
+INSI is appropriate when:
+- Study is specifically about neurointerventional procedures or devices
+- Technique paper for a new or modified approach
+- Case series demonstrating feasibility of a new technique (N = 5–20 acceptable for technical notes)
+- Retrospective registry study with good follow-up
+
+INSI is not appropriate for: purely diagnostic neuroradiology (without intervention), brain tumor imaging without intervention, purely basic science (use JNIS or AJNR for those).

package/skills/write-paper/references/journal_profiles/Investigative_Radiology.md

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+# Investigative Radiology
+
+## Journal Identity
+
+- **Full name**: Investigative Radiology
+- **Abbreviation**: Invest Radiol
+- **Publisher**: Wolters Kluwer / Lippincott Williams & Wilkins
+- **ISSN**: Not specified in guidelines
+- **Frequency**: Monthly
+- **Impact Factor**: Not specified in guidelines
+- **Open Access**: Hybrid (subscription + OA option under CC BY-NC-ND)
+- **APC**: See Wolters Kluwer policies; read-and-publish agreements available
+
+## Manuscript Types and Word Limits
+
+| Type | Abstract | Manuscript Body | References | Figures/Tables |
+|------|----------|----------------|------------|----------------|
+| Original Research | No word limit (structured) | No strict cap | No cap | No strict cap |
+
+Case reports are NOT accepted.
+
+## Abstract Format
+
+Structured with four headings:
+1. **Objectives**
+2. **Materials and Methods**
+3. **Results**
+4. **Conclusions**
+
+No word limit stated. No references in abstract. Limit abbreviations and acronyms.
+
+## Keywords
+
+Up to 10 keywords.
+
+## Required Sections
+
+1. **Introduction**
+2. **Materials and Methods**
+3. **Results**
+4. **Discussion**
+
+Required submission files (all separate):
+- **Cover letter**: authorship statement, COI, ethical adherence
+- **Title page**: title, authors with degrees/affiliations, corresponding author, running head (max 45 characters), funding, COI statement
+- **Acknowledgment section** (optional, separate file)
+- **Manuscript**: title, abstract, keywords, body, tables, figure legends
+- **Figures**: separate image files
+
+## Citation Style
+
+- AMA (American Medical Association) style, 11th edition
+- Numbered sequentially in order of appearance
+- More than 3 authors: list first 3, then "et al."
+- Journal abbreviations per Index Medicus
+- Example: `Rand NS, Dawson JM, Juliao SF, et al. In vivo macrophage recruitment by murine intervertebral disc cells. J Spinal Disord. 2001;14:339-342.`
+- Unpublished data/personal communications: cite in text parenthetically, not in reference list
+
+## Reporting Guidelines
+
+- Follow ICMJE authorship criteria (all four)
+- Declaration of Helsinki for human studies
+- ARRIVE guidelines for animal studies
+- CONSORT for randomized trials
+
+## Statistical Reporting
+
+Follows ICMJE statistical reporting recommendations:
+- Report exact p-values; do not use "P < .05" as a substitute for exact values.
+- 95% CI required for all primary outcomes.
+- Specify the statistical test used for each comparison; parametric vs non-parametric choice must be justified.
+- For diagnostic/prognostic studies: AUC with 95% CI; calibration required for prediction models.
+- Missing data handling must be described in Methods.
+- Statistical software and version required in Methods.
+- No journal-specific statistical reporting requirements beyond ICMJE standards are published; follow discipline-appropriate guidelines (STARD, TRIPOD, STROBE).
+
+## Special Notes
+
+- **Emphasizes early and timely publication** of diagnostic imaging research.
+- **AI policy**: AI tools may NOT be listed as author; use must be disclosed in cover letter and Acknowledgments section. AI use is discouraged.
+- **Co-first authorship**: max 2, requires justification and EIC approval.
+- **Proof turnaround**: 24-48 hours; only critical accuracy corrections allowed.
+- **Self-archiving**: 12-month embargo for accepted manuscripts.
+- **Figures**: line art minimum 1200 dpi; photographs minimum 300 dpi.
+- Tables must be created in Word (NOT Excel).
+- Running head maximum 45 characters including spaces.

package/skills/write-paper/references/journal_profiles/JACC_Advances.md

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+# Journal Profile: JACC: Advances
+
+## Journal Identity
+
+- **Full name**: JACC: Advances
+- **Abbreviation**: JACC Adv
+- **Publisher**: Elsevier (on behalf of the American College of Cardiology)
+- **ISSN**: 2772-963X (online; full open access, no print ISSN)
+- **Frequency**: Monthly
+- **Impact Factor**: Not yet indexed (Web of Science indexing pending as of audit date)
+- **Open Access**: Full Gold OA — APC USD 3,024 (Original Research / Reviews / Methodology / Expert Panel); USD 1,300 (Research Letters / Brief Reports). 10% discount for ACC members and early-career authors (≤10 years post-training); 50% discount for all authors from developing countries.
+- **Acceptance rate**: Not published; broadly estimated 25–35% for Original Research within target scope
+- **Peer review**: Single-blind; statistical review applied selectively (more frequent for methodology-heavy submissions)
+
+## Manuscript Types and Word Limits
+
+| Type | Body Word Limit | Abstract | References | Figures/Tables |
+|------|----------------|----------|------------|----------------|
+| Original Research Paper | 5,000 words (text + refs + figure legends combined) | 250 words (structured) | included in 5,000 | not separately capped |
+| State-of-the-Art Review | 10,000 words | 150 words (unstructured) | included in 10,000 | not separately capped |
+| Methodology Corner | 5,000 words | 250 words (structured) | included in 5,000 | not separately capped |
+| Brief Report | 1,200 words | None | not specified | ≤1 simple figure (≤2 parts) OR 1 table |
+| Research Letter | 1,000 words | None | not specified | ≤1 simple figure (≤2 parts) OR 1 table |
+| Viewpoint | 2,000 words | None | not specified | ≤1 simple figure (≤2 parts) OR 1 table |
+| Editorial Comment | 1,500 words | None | not specified | not specified |
+| JACC: Advances Expert Panel | ≤10,000 or ≤5,000 (per invitation) | 150 words (unstructured) | varies | varies |
+
+The 5,000-word cap for Original Research includes text, references, and figure legends combined — tighter than most cardiology peers; trim aggressively before initial submission.
+
+---
+
+## Abstract Requirements
+
+**Structured abstract for Original Research, 250 words maximum, with 4 explicit headings:**
+
+```
+Background: [Context and knowledge gap]
+Objectives: [Specific aim of the study]
+Methods: [Design, setting, population, exposures, outcomes, analytic approach]
+Results: [Primary results with effect sizes, 95% CIs, P values; N analyzed]
+Conclusions: [Direct answer to objective with clinical/translational implication]
+```
+
+The 4-heading structure (**Background / Objectives / Methods / Results / Conclusions**) differs slightly from Circulation's 4-heading Background / Methods / Results / Conclusions — JACC: Advances inserts an explicit **Objectives** heading between Background and Methods. Reviewers and the editorial system will reject submissions that omit Objectives.
+
+---
+
+## Required Journal-Specific Elements
+
+### 1. Central Illustration
+
+Strongly encouraged for all Original Research. A single panel that conveys the main scientific message — typically a graphical summary combining cohort, key finding (forest plot or Kaplan-Meier), and interpretive caption. Counts toward figure cap.
+
+### 2. Highlights / Key Points (recommended)
+
+Three to five bullet points summarizing the principal contribution at submission.
+
+### 3. Article Information
+
+- Affiliations: department, institution, city, country (numbered superscripts)
+- Corresponding author: full contact details
+- Funding: complete disclosure with grant identifiers
+- Disclosures: per-author conflicts of interest (ICMJE form)
+- Data and code availability statement
+- Acknowledgments separated from disclosures
+
+---
+
+## Required Sections (Original Research)
+
+1. **Introduction** — 2–4 paragraphs ending in a clearly stated objective. JACC: Advances editors tolerate broader scoping than JACC main but still want a tight knowledge-gap framing.
+2. **Methods**
+   - Ethics: IRB approval with institution name and waiver status
+   - Study design, setting, population, eligibility criteria, dates of enrollment
+   - Exposures / interventions
+   - Outcomes: primary, secondary, and exploratory clearly distinguished
+   - Statistical analysis: software (with versions), tests, sample-size or power note, missing-data handling, multiplicity adjustment, sensitivity analyses
+3. **Results** — STROBE/CONSORT flow first; primary outcome before secondary
+4. **Discussion** — 4–6 paragraphs; dedicated Strengths and Limitations sub-paragraphs; conclude with implications and future directions
+5. **Conclusions** — brief (2–3 sentences); avoid overclaiming, especially for small-event composite outcomes
+
+---
+
+## Statistical Reporting
+
+- Exact P values to 3 decimal places (e.g., P = 0.032); use P < 0.001 below threshold
+- 95% CI for all primary effect estimates
+- Effect sizes appropriate to design (HR, sHR, OR, mean difference, AUC)
+- Proportional-hazards assumption check (Schoenfeld) when Cox is used
+- Competing-risks framework (Fine–Gray) when non-CV death competes with CV endpoint
+- Pre-specified sensitivity analyses for major analytic choices (missing data, alternative cutpoints, exposure misclassification)
+- Software and version must be reported
+- For observational cohort: STROBE reporting checklist as supplement, even if not requested in submission portal
+
+---
+
+## Figures
+
+- **No hard cap stated** for Original Research figure count (but tight 5,000-word cap discourages excess)
+- **Brief Reports / Research Letters / Viewpoints**: maximum 1 simple figure (≤2 parts) OR 1 table
+- Resolution: 300 DPI minimum
+- Format: TIFF, EPS, PDF, or high-quality PNG
+- Color: free (full OA model)
+- Central Illustration: 1 figure, square or landscape, conveying main message
+- Supplementary material: unlimited online-only supplement
+
+---
+
+## Common Rejection Reasons
+
+1. **Insufficient novelty within CKM / cardio-metabolic space** — JACC: Advances welcomes incremental contributions but expects a clear delta versus existing JACC family content
+2. **Methodologic gaps** — missing PH check for Cox, missing competing-risks framework when applicable, missing sensitivity analyses
+3. **Overclaiming on small-event composite endpoints** — wide CI estimates narrated without "exploratory" or "hypothesis-generating" qualifiers
+4. **Cohort selection bias unacknowledged** — single-center screening cohorts must explicitly characterize selection direction
+5. **5,000-word cap violation** — failing to combine text + refs + legends within the cap is the single most common pre-review desk reject reason
+6. **Mismatch between Abstract Objectives and Conclusions** — JACC: Advances editors specifically check this alignment
+7. **AI policy non-compliance** — undisclosed AI use in writing/editing, or attempts to fabricate AI-generated images
+
+---
+
+## Cover Letter
+
+Must include:
+- Brief statement of novelty and clinical significance (2–3 sentences)
+- Confirmation manuscript is not under consideration elsewhere
+- Confirmation all authors meet ICMJE criteria
+- Disclosure of related manuscripts (same cohort, same group)
+- Suggested reviewers (3–5; the senior PI should curate)
+- AI disclosure statement aligned with the in-manuscript declaration
+
+---
+
+## AI Writing Disclosure Policy
+
+- **Requirement level**: Required (Elsevier publisher-level policy applies; the JACC: Advances Guide for Authors does not display a journal-specific AI policy as of audit date)
+- **Permitted scope**: AI/LLM tools may be used for language editing, structural review, and internal consistency checks; AI cannot be listed as an author; authorship implies responsibilities that can only be attributed to and performed by humans
+- **Disclosure location**: A separate "Declaration of generative AI and AI-assisted technologies in the writing process" section inserted **immediately above the references**
+- **AI-generated images**: Elsevier does not permit the use of generative AI or AI-assisted tools to create or alter images in submitted manuscripts
+- **Grammar/spell-check exception**: Basic checks of grammar, spelling and punctuation need no declaration
+- **Policy URL**: https://www.elsevier.com/about/policies-and-standards/the-use-of-generative-ai-and-ai-assisted-technologies-in-writing-for-elsevier
+
+---
+
+## Submission Portal
+
+https://www.jaccsubmit-advances.org
+
+---
+
+## Author Guidelines URL
+
+https://www.sciencedirect.com/journal/jacc-advances/publish/guide-for-authors
+
+---
+
+## Positioning
+
+| Criterion | JACC: Advances | JACC main | JACC: Asia | EJPC |
+|-----------|----------------|-----------|------------|------|
+| **Society** | ACC | ACC | ACC (Asia-Pacific focus) | ESC/EAPC |
+| **Impact Factor** | not indexed yet | ~22 | not indexed yet | ~8 |
+| **Open Access** | Full Gold OA ($3,024) | Hybrid | Full Gold OA | Hybrid |
+| **Geographic stance** | Global, no regional anchor | Global, NA-centric | Asia-Pacific anchor | Europe-centric |
+| **Event-count tolerance** | Moderate (welcomes exploratory framings with adequate caveats) | High (expects definitive outcomes) | Moderate (Asia-Pacific data privileged) | Moderate (prevention-focused) |
+| **Submission angle** | "Novel framework application or extension of CKM/CV evidence" | "Practice-changing or guideline-shifting finding" | "Asia-Pacific cardiovascular evidence" | "Cardiovascular prevention, rehabilitation, or epidemiology" |
+| **Abstract style** | 4-heading (Background/Objectives/Methods/Results/Conclusions, 250 words) | Unstructured 250 words | Same as JACC: Advances | 4-heading (Aims/Methods/Results/Conclusion, 250 words) |
+| **Word cap (Original)** | 5,000 (incl. refs + legends) | 5,000 | 5,000 | 5,000 |
+| **AI policy** | Elsevier publisher-level (no journal page) | ACC/Elsevier | ACC/Elsevier | OUP/ESC explicit on guidelines page |
+
+**Choose JACC: Advances when:**
+- AHA 2023 CKM framework or other society-aligned framework application
+- Korean / non-Western cohort with broad generalizability narrative (not Asia-specific anchor)
+- Observational cohort with modest event count that needs "exploratory but rigorous" reception
+- Authors who value Gold OA and ACC ecosystem visibility over JCR-indexed IF (transitional period)
+
+**Choose JACC main instead when:**
+- Multicenter, large-event-count, practice-changing finding
+- Findings likely to be cited in ACC/AHA guidelines within 1–2 years
+- Higher IF requirement (e.g., faculty promotion tracks)
+
+**Choose JACC: Asia instead when:**
+- Asia-Pacific regional contribution is the dominant framing (not "first Korean ___")
+- Asia-Pacific healthcare-system policy implications are central
+
+**Choose EJPC instead when:**
+- Primary prevention angle is dominant
+- ESC/EAPC ecosystem reach matters more than ACC reach
+- Manuscript needs sponsor society alignment with European preventive cardiology community
+
+---
+
+## Verification Notes
+
+Audit performed 2026-05-20. Sources opened:
+- Homepage: https://www.sciencedirect.com/journal/jacc-advances (ISSN, EIC, APC, scope)
+- Guide for Authors: https://www.sciencedirect.com/journal/jacc-advances/publish/guide-for-authors (article types, word limits, abstract structure, references, figures, submission portal)
+- Elsevier publisher AI policy: https://www.elsevier.com/about/policies-and-standards/the-use-of-generative-ai-and-ai-assisted-technologies-in-writing-for-elsevier (AI policy verbatim source)