medsci-skills 4.1.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (702) hide show
  1. package/LICENSE +50 -0
  2. package/README.md +602 -0
  3. package/README_FIRST.md +27 -0
  4. package/bin/medsci-skills.js +159 -0
  5. package/installers/install-macos.command +19 -0
  6. package/installers/install-windows.cmd +26 -0
  7. package/installers/install-windows.ps1 +17 -0
  8. package/installers/install.py +218 -0
  9. package/metadata/skills_catalog.json +452 -0
  10. package/package.json +48 -0
  11. package/skills/academic-aio/SKILL.md +408 -0
  12. package/skills/academic-aio/references/case_studies/kjr_mllm_2025.md +82 -0
  13. package/skills/academic-aio/references/checklists/AIO_GENERAL.md +354 -0
  14. package/skills/academic-aio/references/journal_summarybox_templates.yaml +126 -0
  15. package/skills/academic-aio/references/oac_funding_checklist.yaml +129 -0
  16. package/skills/academic-aio/references/reporting_guideline_mapping.md +39 -0
  17. package/skills/academic-aio/references/schema_markup_templates/CodeRepository.jsonld +32 -0
  18. package/skills/academic-aio/references/schema_markup_templates/Dataset.jsonld +36 -0
  19. package/skills/academic-aio/references/schema_markup_templates/Person.jsonld +30 -0
  20. package/skills/academic-aio/references/schema_markup_templates/README.md +43 -0
  21. package/skills/academic-aio/references/schema_markup_templates/ScholarlyArticle.jsonld +55 -0
  22. package/skills/academic-aio/scripts/batch_metadata_audit.py +169 -0
  23. package/skills/academic-aio/scripts/validate_schema.py +118 -0
  24. package/skills/academic-aio/skill.yml +36 -0
  25. package/skills/academic-aio/templates/aio_audit_checklist.md.j2 +108 -0
  26. package/skills/add-journal/SKILL.md +482 -0
  27. package/skills/add-journal/skill.yml +33 -0
  28. package/skills/analyze-stats/SKILL.md +598 -0
  29. package/skills/analyze-stats/references/analysis_guides/missing_data.md +109 -0
  30. package/skills/analyze-stats/references/analysis_guides/nhis_icd10_mapping.md +247 -0
  31. package/skills/analyze-stats/references/analysis_guides/propensity_score.md +132 -0
  32. package/skills/analyze-stats/references/analysis_guides/regression.md +115 -0
  33. package/skills/analyze-stats/references/analysis_guides/repeated_measures.md +160 -0
  34. package/skills/analyze-stats/references/analysis_guides/survey_weighted.md +366 -0
  35. package/skills/analyze-stats/references/analysis_guides/test_selection.md +86 -0
  36. package/skills/analyze-stats/references/style/figure_style.mplstyle +69 -0
  37. package/skills/analyze-stats/references/style/theme_publication.R +147 -0
  38. package/skills/analyze-stats/references/table-standards/journal-profiles/ajr.yaml +51 -0
  39. package/skills/analyze-stats/references/table-standards/journal-profiles/european_radiology.yaml +55 -0
  40. package/skills/analyze-stats/references/table-standards/journal-profiles/jama.yaml +66 -0
  41. package/skills/analyze-stats/references/table-standards/journal-profiles/lancet.yaml +57 -0
  42. package/skills/analyze-stats/references/table-standards/journal-profiles/nejm.yaml +51 -0
  43. package/skills/analyze-stats/references/table-standards/journal-profiles/radiology.yaml +66 -0
  44. package/skills/analyze-stats/references/table-standards/table-standards.md +287 -0
  45. package/skills/analyze-stats/references/table-standards/table-types/diagnostic_accuracy.md +36 -0
  46. package/skills/analyze-stats/references/table-standards/table-types/meta_analysis.md +58 -0
  47. package/skills/analyze-stats/references/table-standards/table-types/model_comparison.md +36 -0
  48. package/skills/analyze-stats/references/table-standards/table-types/regression_results.md +50 -0
  49. package/skills/analyze-stats/references/table-standards/table-types/table1_demographics.md +51 -0
  50. package/skills/analyze-stats/references/table-standards/tool-comparison.md +79 -0
  51. package/skills/analyze-stats/references/templates/agreement_analysis.py +436 -0
  52. package/skills/analyze-stats/references/templates/dca_plot.R +237 -0
  53. package/skills/analyze-stats/references/templates/diagnostic_accuracy.py +401 -0
  54. package/skills/analyze-stats/references/templates/dta_meta_analysis.R +384 -0
  55. package/skills/analyze-stats/references/templates/forest_plot.py +412 -0
  56. package/skills/analyze-stats/references/templates/likert_summary.py +356 -0
  57. package/skills/analyze-stats/references/templates/meta_analysis.R +365 -0
  58. package/skills/analyze-stats/references/templates/propensity_score.py +478 -0
  59. package/skills/analyze-stats/references/templates/regression.py +425 -0
  60. package/skills/analyze-stats/references/templates/repeated_measures.py +434 -0
  61. package/skills/analyze-stats/references/templates/sample_size.R +382 -0
  62. package/skills/analyze-stats/references/templates/survey_weighted_analysis.py +411 -0
  63. package/skills/analyze-stats/references/templates/survival_analysis.py +325 -0
  64. package/skills/analyze-stats/references/templates/table1_demographics.py +287 -0
  65. package/skills/analyze-stats/scripts/check_generated_code.py +335 -0
  66. package/skills/analyze-stats/skill.yml +38 -0
  67. package/skills/analyze-stats/tests/fixtures/gen_bad.R +16 -0
  68. package/skills/analyze-stats/tests/fixtures/gen_bad.py +24 -0
  69. package/skills/analyze-stats/tests/fixtures/gen_clean.py +21 -0
  70. package/skills/analyze-stats/tests/test_generated_code.sh +59 -0
  71. package/skills/analyze-stats/tests/test_survival_template.sh +53 -0
  72. package/skills/author-strategy/SKILL.md +117 -0
  73. package/skills/author-strategy/analyze_patterns.py +303 -0
  74. package/skills/author-strategy/fetch_pubmed.py +374 -0
  75. package/skills/author-strategy/skill.yml +34 -0
  76. package/skills/batch-cohort/SKILL.md +223 -0
  77. package/skills/batch-cohort/references/base_template_knhanes.R +210 -0
  78. package/skills/batch-cohort/references/batch_template_generator.R +222 -0
  79. package/skills/batch-cohort/references/variable_coding_registry.md +136 -0
  80. package/skills/batch-cohort/skill.yml +35 -0
  81. package/skills/calc-sample-size/SKILL.md +491 -0
  82. package/skills/calc-sample-size/references/formulas.md +655 -0
  83. package/skills/calc-sample-size/references/observational_cohort.md +49 -0
  84. package/skills/calc-sample-size/skill.yml +51 -0
  85. package/skills/check-reporting/SKILL.md +534 -0
  86. package/skills/check-reporting/references/LICENSES.md +41 -0
  87. package/skills/check-reporting/references/checklists/AMSTAR2.md +54 -0
  88. package/skills/check-reporting/references/checklists/ARRIVE_2.md +234 -0
  89. package/skills/check-reporting/references/checklists/CARE.md +102 -0
  90. package/skills/check-reporting/references/checklists/CLAIM_2024.md +128 -0
  91. package/skills/check-reporting/references/checklists/CLEAR.md +113 -0
  92. package/skills/check-reporting/references/checklists/CONSORT.md +86 -0
  93. package/skills/check-reporting/references/checklists/COSMIN_RoB.md +136 -0
  94. package/skills/check-reporting/references/checklists/GRRAS.md +61 -0
  95. package/skills/check-reporting/references/checklists/MI_CLEAR_LLM.md +167 -0
  96. package/skills/check-reporting/references/checklists/MOOSE.md +85 -0
  97. package/skills/check-reporting/references/checklists/NOS.md +88 -0
  98. package/skills/check-reporting/references/checklists/PRISMA_2020.md +135 -0
  99. package/skills/check-reporting/references/checklists/PRISMA_DTA.md +36 -0
  100. package/skills/check-reporting/references/checklists/PRISMA_P.md +56 -0
  101. package/skills/check-reporting/references/checklists/PROBAST.md +75 -0
  102. package/skills/check-reporting/references/checklists/PROBAST_AI.md +130 -0
  103. package/skills/check-reporting/references/checklists/QUADAS2.md +77 -0
  104. package/skills/check-reporting/references/checklists/QUADAS_C.md +131 -0
  105. package/skills/check-reporting/references/checklists/ROBINS_E.md +179 -0
  106. package/skills/check-reporting/references/checklists/ROBINS_I.md +87 -0
  107. package/skills/check-reporting/references/checklists/ROBIS.md +114 -0
  108. package/skills/check-reporting/references/checklists/ROB_ME.md +126 -0
  109. package/skills/check-reporting/references/checklists/RoB2.md +79 -0
  110. package/skills/check-reporting/references/checklists/RoB_NMA.md +96 -0
  111. package/skills/check-reporting/references/checklists/SPIRIT.md +112 -0
  112. package/skills/check-reporting/references/checklists/SQUIRE_2.md +68 -0
  113. package/skills/check-reporting/references/checklists/STARD.md +129 -0
  114. package/skills/check-reporting/references/checklists/STARD_AI.md +211 -0
  115. package/skills/check-reporting/references/checklists/STROBE.md +80 -0
  116. package/skills/check-reporting/references/checklists/SWiM.md +33 -0
  117. package/skills/check-reporting/references/checklists/TRIPOD.md +157 -0
  118. package/skills/check-reporting/references/checklists/TRIPOD_AI.md +140 -0
  119. package/skills/check-reporting/references/step4c_registration_timing.md +93 -0
  120. package/skills/check-reporting/references/step4d_prisma_figure_audit.md +137 -0
  121. package/skills/check-reporting/scripts/check_checklist_exists.py +183 -0
  122. package/skills/check-reporting/scripts/check_checklist_version.py +168 -0
  123. package/skills/check-reporting/scripts/check_framework_naming.py +206 -0
  124. package/skills/check-reporting/scripts/check_prisma_figure.py +209 -0
  125. package/skills/check-reporting/scripts/prisma_cascade_check.py +274 -0
  126. package/skills/check-reporting/skill.yml +41 -0
  127. package/skills/check-reporting/tests/fixtures/framework_bad.md +8 -0
  128. package/skills/check-reporting/tests/fixtures/framework_clean.md +7 -0
  129. package/skills/check-reporting/tests/test_checklist_fail_fast.sh +77 -0
  130. package/skills/check-reporting/tests/test_checklist_version.sh +72 -0
  131. package/skills/check-reporting/tests/test_framework_naming.sh +45 -0
  132. package/skills/check-reporting/tests/test_prisma_cascade.sh +104 -0
  133. package/skills/clean-data/SKILL.md +180 -0
  134. package/skills/clean-data/references/cleaning_patterns.md +299 -0
  135. package/skills/clean-data/references/profiling_template.py +304 -0
  136. package/skills/clean-data/scripts/check_structural_zero.py +174 -0
  137. package/skills/clean-data/skill.yml +35 -0
  138. package/skills/clean-data/tests/fixtures/smoking.csv +8 -0
  139. package/skills/clean-data/tests/test_structural_zero.sh +49 -0
  140. package/skills/cross-national/SKILL.md +264 -0
  141. package/skills/cross-national/skill.yml +37 -0
  142. package/skills/define-variables/SKILL.md +146 -0
  143. package/skills/define-variables/references/common_definitions.md +190 -0
  144. package/skills/define-variables/skill.yml +34 -0
  145. package/skills/define-variables/templates/variable_operationalization.md +64 -0
  146. package/skills/deidentify/SKILL.md +203 -0
  147. package/skills/deidentify/deidentify.py +1224 -0
  148. package/skills/deidentify/locales/_template.json +45 -0
  149. package/skills/deidentify/locales/au.json +43 -0
  150. package/skills/deidentify/locales/ca.json +44 -0
  151. package/skills/deidentify/locales/cn.json +47 -0
  152. package/skills/deidentify/locales/de.json +48 -0
  153. package/skills/deidentify/locales/fr.json +48 -0
  154. package/skills/deidentify/locales/in.json +48 -0
  155. package/skills/deidentify/locales/jp.json +48 -0
  156. package/skills/deidentify/locales/kr.json +48 -0
  157. package/skills/deidentify/locales/uk.json +45 -0
  158. package/skills/deidentify/locales/us.json +43 -0
  159. package/skills/deidentify/references/date_shift_guide.md +82 -0
  160. package/skills/deidentify/references/hipaa_18_identifiers.md +48 -0
  161. package/skills/deidentify/references/korean_phi_patterns.md +135 -0
  162. package/skills/deidentify/skill.yml +43 -0
  163. package/skills/deidentify/tests/README.md +26 -0
  164. package/skills/deidentify/tests/test_clean.csv +16 -0
  165. package/skills/deidentify/tests/test_edge_cases.csv +11 -0
  166. package/skills/deidentify/tests/test_phi_korean.csv +11 -0
  167. package/skills/design-ai-benchmarking/SKILL.md +214 -0
  168. package/skills/design-ai-benchmarking/references/benchmark_export_schema.json +69 -0
  169. package/skills/design-ai-benchmarking/references/elicitation_rubric_template.md +37 -0
  170. package/skills/design-ai-benchmarking/skill.yml +38 -0
  171. package/skills/design-study/SKILL.md +298 -0
  172. package/skills/design-study/skill.yml +33 -0
  173. package/skills/fill-icmje-coi/SKILL.md +216 -0
  174. package/skills/fill-icmje-coi/scripts/fill_icmje_coi.py +140 -0
  175. package/skills/fill-icmje-coi/skill.yml +35 -0
  176. package/skills/fill-icmje-coi/templates/icmje_coi_seed_synthetic.docx +0 -0
  177. package/skills/fill-protocol/SKILL.md +248 -0
  178. package/skills/fill-protocol/examples/example_irb_template.yaml +53 -0
  179. package/skills/fill-protocol/references/best_practices.md +121 -0
  180. package/skills/fill-protocol/scripts/doc_to_docx.py +111 -0
  181. package/skills/fill-protocol/scripts/fill_form.py +611 -0
  182. package/skills/fill-protocol/scripts/inspect_template.py +61 -0
  183. package/skills/fill-protocol/setup.sh +162 -0
  184. package/skills/fill-protocol/skill.yml +37 -0
  185. package/skills/find-cohort-gap/SKILL.md +309 -0
  186. package/skills/find-cohort-gap/references/cohort_profile_template.md +93 -0
  187. package/skills/find-cohort-gap/references/onepager_template.md +84 -0
  188. package/skills/find-cohort-gap/references/pattern_scoring_rubric.md +169 -0
  189. package/skills/find-cohort-gap/references/saturation_query_templates.md +143 -0
  190. package/skills/find-cohort-gap/skill.yml +35 -0
  191. package/skills/find-journal/POLICY.md +87 -0
  192. package/skills/find-journal/SKILL.md +340 -0
  193. package/skills/find-journal/references/journal_profiles/AJNR.md +29 -0
  194. package/skills/find-journal/references/journal_profiles/AJR.md +30 -0
  195. package/skills/find-journal/references/journal_profiles/Abdominal_Radiology.md +30 -0
  196. package/skills/find-journal/references/journal_profiles/Academic_Radiology.md +30 -0
  197. package/skills/find-journal/references/journal_profiles/Annals_of_Internal_Medicine.md +33 -0
  198. package/skills/find-journal/references/journal_profiles/Artificial_Intelligence_in_Medicine.md +28 -0
  199. package/skills/find-journal/references/journal_profiles/BMC_Medicine.md +31 -0
  200. package/skills/find-journal/references/journal_profiles/British_Journal_of_Radiology.md +39 -0
  201. package/skills/find-journal/references/journal_profiles/CVIR.md +30 -0
  202. package/skills/find-journal/references/journal_profiles/Chest.md +39 -0
  203. package/skills/find-journal/references/journal_profiles/Clinical_Radiology.md +30 -0
  204. package/skills/find-journal/references/journal_profiles/Clinical_and_Molecular_Hepatology.md +32 -0
  205. package/skills/find-journal/references/journal_profiles/Diabetes_Metabolism_Journal.md +36 -0
  206. package/skills/find-journal/references/journal_profiles/Diagnostic_and_Interventional_Radiology.md +32 -0
  207. package/skills/find-journal/references/journal_profiles/Endocrinology_and_Metabolism.md +37 -0
  208. package/skills/find-journal/references/journal_profiles/European_Journal_of_Preventive_Cardiology.md +39 -0
  209. package/skills/find-journal/references/journal_profiles/European_Radiology.md +29 -0
  210. package/skills/find-journal/references/journal_profiles/Hepatology_Communications.md +40 -0
  211. package/skills/find-journal/references/journal_profiles/Hepatology_International.md +37 -0
  212. package/skills/find-journal/references/journal_profiles/IEEE_JBHI.md +28 -0
  213. package/skills/find-journal/references/journal_profiles/IEEE_TMI.md +28 -0
  214. package/skills/find-journal/references/journal_profiles/INSI.md +29 -0
  215. package/skills/find-journal/references/journal_profiles/Investigative_Radiology.md +25 -0
  216. package/skills/find-journal/references/journal_profiles/JACC_Advances.md +41 -0
  217. package/skills/find-journal/references/journal_profiles/JACC_Asia.md +30 -0
  218. package/skills/find-journal/references/journal_profiles/JACR.md +28 -0
  219. package/skills/find-journal/references/journal_profiles/JAMA.md +40 -0
  220. package/skills/find-journal/references/journal_profiles/JAMA_Network_Open.md +30 -0
  221. package/skills/find-journal/references/journal_profiles/JCSM.md +39 -0
  222. package/skills/find-journal/references/journal_profiles/JKMS.md +32 -0
  223. package/skills/find-journal/references/journal_profiles/JMIR.md +29 -0
  224. package/skills/find-journal/references/journal_profiles/JMIR_Medical_Education.md +29 -0
  225. package/skills/find-journal/references/journal_profiles/JNIS.md +35 -0
  226. package/skills/find-journal/references/journal_profiles/JVIR.md +31 -0
  227. package/skills/find-journal/references/journal_profiles/Journal_of_Biomedical_Informatics.md +29 -0
  228. package/skills/find-journal/references/journal_profiles/Journal_of_Clinical_Endocrinology_and_Metabolism.md +40 -0
  229. package/skills/find-journal/references/journal_profiles/Journal_of_Magnetic_Resonance_Imaging.md +30 -0
  230. package/skills/find-journal/references/journal_profiles/Journal_of_Nuclear_Medicine.md +31 -0
  231. package/skills/find-journal/references/journal_profiles/Journal_of_Stroke.md +32 -0
  232. package/skills/find-journal/references/journal_profiles/KJR.md +38 -0
  233. package/skills/find-journal/references/journal_profiles/Korean_Circulation_Journal.md +38 -0
  234. package/skills/find-journal/references/journal_profiles/Korean_Journal_of_Internal_Medicine.md +36 -0
  235. package/skills/find-journal/references/journal_profiles/Lancet_Diabetes_and_Endocrinology.md +40 -0
  236. package/skills/find-journal/references/journal_profiles/Lancet_Gastroenterology_and_Hepatology.md +49 -0
  237. package/skills/find-journal/references/journal_profiles/Lancet_Infectious_Diseases.md +38 -0
  238. package/skills/find-journal/references/journal_profiles/Lancet_Neurology.md +39 -0
  239. package/skills/find-journal/references/journal_profiles/Lancet_Oncology.md +40 -0
  240. package/skills/find-journal/references/journal_profiles/Lancet_Psychiatry.md +38 -0
  241. package/skills/find-journal/references/journal_profiles/Lancet_Public_Health.md +30 -0
  242. package/skills/find-journal/references/journal_profiles/Lancet_Respiratory_Medicine.md +39 -0
  243. package/skills/find-journal/references/journal_profiles/Liver_International.md +33 -0
  244. package/skills/find-journal/references/journal_profiles/Medical_Image_Analysis.md +28 -0
  245. package/skills/find-journal/references/journal_profiles/NEJM.md +33 -0
  246. package/skills/find-journal/references/journal_profiles/Nature_Machine_Intelligence.md +31 -0
  247. package/skills/find-journal/references/journal_profiles/Nature_Medicine.md +39 -0
  248. package/skills/find-journal/references/journal_profiles/Neuroradiology.md +31 -0
  249. package/skills/find-journal/references/journal_profiles/Nutrition_Metabolism_and_Cardiovascular_Diseases.md +39 -0
  250. package/skills/find-journal/references/journal_profiles/PLOS_Medicine.md +32 -0
  251. package/skills/find-journal/references/journal_profiles/RYAI.md +28 -0
  252. package/skills/find-journal/references/journal_profiles/Radiology.md +29 -0
  253. package/skills/find-journal/references/journal_profiles/Skeletal_Radiology.md +31 -0
  254. package/skills/find-journal/references/journal_profiles/Stroke.md +37 -0
  255. package/skills/find-journal/references/journal_profiles/The_BMJ.md +31 -0
  256. package/skills/find-journal/references/journal_profiles/The_Lancet.md +31 -0
  257. package/skills/find-journal/references/journal_profiles/The_Lancet_Digital_Health.md +29 -0
  258. package/skills/find-journal/references/journal_profiles/World_Journal_of_Hepatology.md +53 -0
  259. package/skills/find-journal/references/journal_profiles/npj_Digital_Medicine.md +29 -0
  260. package/skills/find-journal/skill.yml +34 -0
  261. package/skills/fulltext-retrieval/SKILL.md +174 -0
  262. package/skills/fulltext-retrieval/fetch_oa.py +433 -0
  263. package/skills/fulltext-retrieval/pdf_to_md.py +160 -0
  264. package/skills/fulltext-retrieval/skill.yml +41 -0
  265. package/skills/generate-codebook/SKILL.md +155 -0
  266. package/skills/generate-codebook/references/codebook_schema.md +76 -0
  267. package/skills/generate-codebook/scripts/generate_codebook.py +278 -0
  268. package/skills/generate-codebook/skill.yml +35 -0
  269. package/skills/generate-codebook/tests/test_generate_codebook.sh +76 -0
  270. package/skills/grant-builder/SKILL.md +251 -0
  271. package/skills/grant-builder/skill.yml +34 -0
  272. package/skills/humanize/SKILL.md +251 -0
  273. package/skills/humanize/references/ai_patterns.md +571 -0
  274. package/skills/humanize/skill.yml +33 -0
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@@ -0,0 +1,515 @@
1
+ ---
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+ name: revise
3
+ description: Parse peer reviewer comments and generate a structured Response to Reviewers document with tracked manuscript changes. Classifies comments as MAJOR/MINOR/REBUTTAL, coordinates new analyses with /analyze-stats and /make-figures, and produces cover letter for editor.
4
+ triggers: revise paper, respond to reviewers, revision letter, reviewer comments, major revision, minor revision, resubmit, R1 revision, revision round, response letter, point-by-point response
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+ tools: Read, Write, Edit, Bash, Grep, Glob
6
+ model: inherit
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+ ---
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+
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+ # Revision Skill -- Response to Peer Reviewers
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+
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+ ## Purpose
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+
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+ Parse reviewer decision letters, classify each comment by type, generate a formal Response to Reviewers document, track required manuscript changes, and coordinate with /analyze-stats or /make-figures when new analyses or visuals are needed.
14
+
15
+ ---
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+
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+ ## Activation
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+
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+ When the user provides reviewer comments (pasted text, PDF, or file path), or requests revision of a manuscript, this skill activates. Before proceeding, confirm:
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+
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+ 1. The reviewer decision letter (pasted text or file path)
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+ 2. The current manuscript file (`paper/main.tex` or `paper/main.qmd`)
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+ 3. The revision round number (default: R1)
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+ 4. The journal name (affects cover letter format)
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+
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+ ---
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+
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+ ## Reference Files
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+
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+ - **Response-letter voice gallery**: `${CLAUDE_SKILL_DIR}/references/r2r_voice.md` -- before/after examples, three response skeletons (accept / partial-accept / polite-rebuttal), and a meta-phrase-to-natural conversion table. Read it before drafting the Response to Reviewers document.
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+
32
+ ---
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+
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+ ## Step 1: Parse and Number All Comments
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+
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+ Read the full decision letter. Extract every discrete comment from every reviewer and the editor.
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+
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+ ### Numbering Convention
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+
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+ ```
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+ E-1, E-2, ... <- Editor comments
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+ R1-1, R1-2, ... <- Reviewer 1 comments
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+ R2-1, R2-2, ... <- Reviewer 2 comments
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+ R3-1, R3-2, ... <- Reviewer 3 (if present)
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+ ```
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+
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+ If a reviewer groups multiple requests in one paragraph, split them into sub-items: `R1-3a, R1-3b, R1-3c`
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+
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+ ### Classification
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+
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+ | Type | Symbol | Definition |
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+ |------|--------|------------|
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+ | **MAJOR** | `[MAJ]` | Requires new experiment, re-analysis, new figure/table, or substantial structural rewrite |
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+ | **MINOR** | `[MIN]` | Requires text revision, clarification, formatting change, or additional citation |
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+ | **REBUTTAL** | `[REB]` | Reviewer is factually incorrect, misunderstood the study, or requests something scientifically unjustified |
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+
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+ Output a classified comment list before generating responses:
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+
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+ ```
60
+ E-1 [MIN] Request to shorten abstract
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+ R1-1 [MAJ] Requires subgroup analysis by scanner type
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+ R1-2 [MIN] Clarify exclusion criteria rationale
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+ R1-3 [REB] Claims our sample size is underpowered (we disagree)
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+ R2-1 [MAJ] Requires additional figure showing calibration curve
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+ R2-2 [MIN] Add reference to [Author Year]
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+ ```
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+
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+ **Gate:** Present the classified comment list to the user. Confirm classifications
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+ (especially REBUTTAL vs MAJOR) before generating responses. A misclassified REBUTTAL
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+ generates a response that argues with a valid reviewer point.
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+
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+ ---
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+
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+ ## Step 2: Triage -- Flag External Actions Needed
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+
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+ Before writing responses, identify which comments require external action:
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+
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+ **Comments requiring /analyze-stats:** Flag any MAJOR comment that requires new statistical analysis, re-run of existing analysis, additional metric (calibration, NRI, ICC), or sample size recalculation.
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+
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+ **Comments requiring /make-figures:** Flag any MAJOR comment that requires a new figure or revised figure (calibration plot, subgroup forest plot, Bland-Altman, new panel).
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+
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+ Output: "The following comments require statistical analysis before responses can be finalized: R1-1, R2-3. Run /analyze-stats with these tasks, then return to /revise."
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+
84
+ ---
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+
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+ ## Step 2.5: Revision Numerical Lineage Check (MANDATORY)
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+
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+ Revision-time is the highest-risk moment for numerical hallucinations. A new analysis script
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+ written to satisfy a reviewer — typically a comparative arm, a subgroup, or a sensitivity
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+ check — frequently hand-enters values copied by eye from the original paper's tables, bypassing
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+ the locked extraction CSV. The resulting numbers then flow into the response letter, the
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+ revised manuscript, and regenerated figures, and they can be internally consistent everywhere
93
+ while still being wrong at the source.
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+
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+ **Precedent failure pattern — treat as a lived failure, not hypothetical:**
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+ > An R1 revision introduced a new comparative-arm analysis script to answer a reviewer
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+ > request. The Fisher exact matrix was hand-typed from the primary source Table, with an
98
+ > adjacent severity-grade column misread as the event count. The script, the revised
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+ > manuscript, and an accompanying Table all converged on the same direction-reversed
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+ > numbers relative to what the primary source actually reported.
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+
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+ **Non-negotiable actions when Step 2 flags any `/analyze-stats` re-run:**
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+
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+ 1. **Tag every new numerical claim with `[VERIFY-CSV]`** as it is written into the revised
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+ manuscript, response letter, or new table. The tag is a tripwire — it only comes off at
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+ Step 7 (Final Verification) after explicit CSV + primary-source back-check.
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+
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+ 2. **New analysis scripts must read from the locked extraction CSV.** Hand-typed `matrix()`,
109
+ `c(...)`, or `data.frame(...)` numerical inputs are PROHIBITED when a CSV row exists. If
110
+ hand entry is truly unavoidable (e.g., comparative-arm subset not present in the CSV), the
111
+ line MUST carry a comment citing the CSV coordinate AND the primary-source Table/Figure:
112
+ ```r
113
+ # source: data_extraction_final.csv row <N> (<first-author> <year>, <arm> only),
114
+ # verified against <primary source> Table <X>, page <P>
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+ fisher.test(matrix(c(0, 45, 1, 55), nrow = 2, byrow = FALSE))
116
+ ```
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+
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+ 3. **Comparative / arm-specific values must enter `extraction_consensus_log.md` as separate
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+ rows** before the analysis script references them. Do not let a new script invent values
120
+ that never passed through the dual-extraction consensus layer.
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+
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+ 4. **Revision-time numerical audit table** — maintain this inside the response document draft
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+ and copy into the final change log:
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+
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+ | New claim (response + manuscript location) | Source script:line | CSV row/col | Primary source (Table/Fig, page) | Match? |
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+ |---|---|---|---|---|
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+
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+ 5. **Gate before Step 3** — do not generate response prose for a MAJOR comment whose new
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+ numbers have not yet cleared this check. Prose written around un-audited numbers is very
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+ hard to unwind cleanly after a mismatch is found.
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+
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+ **Why this matters for reviewer politics:** a numerical reversal caught by the reviewer in R2
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+ is far more damaging than the same error caught internally in R1 — it implies extraction
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+ integrity problems to the editor and licenses deeper scrutiny of the rest of the data. Treat
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+ Step 2.5 as a reputation-preservation gate, not just a QC step.
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+
137
+ ---
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+
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+ ## Step 3: Generate Response to Reviewers Document
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+
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+ **Output location:** `revision/R[N]/response_to_reviewers_R[N].md`
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+
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+ ### Document Header
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+
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+ ```
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+ Response to Reviewers
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+
148
+ Manuscript ID: [JOURNAL-XXXXX]
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+ Manuscript Title: [Full title]
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+ Authors: [Last name of first author] et al.
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+ Revision Round: [R1 / R2 / R3]
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+ Date: [YYYY-MM-DD]
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+
154
+ We thank the Editor and reviewers for their careful reading of our manuscript
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+ and their constructive comments. We have revised the manuscript accordingly
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+ and provide a point-by-point response below. All changes are shown in the
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+ revised manuscript with tracked changes (or highlighted in yellow).
158
+ ```
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+
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+ ### Per-Comment Response Block
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+
162
+ ```
163
+ ---
164
+
165
+ **Comment R[X]-[Y]** [MAJ/MIN/REB]
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+
167
+ *Reviewer's comment:*
168
+ > [Exact text of the comment, quoted verbatim]
169
+
170
+ **Response:**
171
+
172
+ [Response text -- format by type below]
173
+
174
+ **Manuscript change:**
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+ - Section: [Methods / Results / Discussion / etc.]
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+ - Page [X], Line [Y] (in the revised manuscript)
177
+ - [Quote the new or changed sentence if short]
178
+ ```
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+
180
+ ---
181
+
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+ ## Step 4: Response Formats by Comment Type
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+
184
+ ### MINOR Comment
185
+
186
+ Keep concise (3-8 sentences). Acknowledge, explain the change.
187
+
188
+ ```
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+ We thank the reviewer for this observation. We have [describe change] in
190
+ the [section] section. The revised text now reads: "[new sentence]."
191
+ ```
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+
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+ ### MAJOR Comment
194
+
195
+ Structured response with four parts: acknowledgment -> new analysis -> key result -> location of changes.
196
+
197
+ ```
198
+ We thank the reviewer for this important suggestion. [State the concern.]
199
+
200
+ To address this, we [describe new analysis/experiment/rewrite].
201
+ [Key result: metric = value (95% CI, lower-upper; P = exact value)]
202
+ (All new results MUST include 95% CI and exact p-value.)
203
+
204
+ This finding [supports / strengthens / does not change] our original
205
+ conclusion because [brief interpretation].
206
+
207
+ Note: New text added to the Results section must contain only factual
208
+ findings. Interpretation belongs in the response letter text or Discussion.
209
+
210
+ We have added:
211
+ - New [Table X / Figure X / Supplementary Table X] showing [content]
212
+ - Methods revised: Page X, Lines Y-Z
213
+ - Results revised: Page X, Lines Y-Z
214
+ ```
215
+
216
+ ### REBUTTAL Comment
217
+
218
+ Polite but firm. Do not capitulate without scientific justification.
219
+
220
+ ```
221
+ We thank the reviewer for raising this point. We respectfully suggest
222
+ that [restate reviewer's claim], while we [state your position].
223
+
224
+ [Explanation with supporting evidence. Cite literature if available:
225
+ "This is consistent with [Author et al., Year; PMID XXXXXX], who
226
+ demonstrated that..."]
227
+
228
+ [If applicable: "We have added the following clarifying sentence to
229
+ [section] (Page X, Line Y): '[new sentence].'"]
230
+
231
+ We believe this issue does not warrant [the specific change requested]
232
+ because [reason]. We hope the reviewer finds this explanation satisfactory.
233
+ ```
234
+
235
+ **Voice caution:** The acknowledgment lines in these templates are schematic placeholders, not literal text to paste under every comment. Repeating the same opener ("We thank the reviewer for this important suggestion.") across a dozen responses is itself an AI-tell that careful reviewers notice. Vary the openers and apply the **Response-Letter Voice & AI-Tell Avoidance** section below before finalizing any response.
236
+
237
+ ---
238
+
239
+ ## 5-Category Triage Strategy
240
+
241
+ Before writing individual responses, classify every comment into one of five categories.
242
+ This classification determines the response template and effort level. Process Category 1
243
+ (Simple) comments first — they are the most numerous and clearing them early reduces the
244
+ perceived workload.
245
+
246
+ ### Category 1: Simple Question (most common)
247
+
248
+ Reviewer asks for additional description, clarification, or minor data.
249
+ **Response**: Add the requested text and point to the location. Keep the response short.
250
+ **Example**: "Please specify the study period" → add dates, reply "Done. See page X, line Y."
251
+
252
+ ### Category 2: Misunderstanding
253
+
254
+ Reviewer misinterpreted the study design, population, or analysis.
255
+ **Response**: Never say "you are wrong." Instead: "We apologize for the lack of clarity"
256
+ → re-explain the intended meaning → revise the manuscript text to prevent future confusion.
257
+
258
+ ### Category 3: Further Discussion
259
+
260
+ Reviewer raises a contextual concern (different healthcare system, different clinical practice).
261
+ **Response**: Acknowledge the valid perspective → explain your study context → add a brief
262
+ note in Discussion if appropriate. The full explanation can stay in the response letter
263
+ without bloating the manuscript.
264
+
265
+ ### Category 4: Additional Results
266
+
267
+ Reviewer requests new analysis (subgroup, sensitivity, additional metric).
268
+ **Response**: Perform the analysis → add results to Supplementary (or main text if important)
269
+ → describe what was done and what was found. Treat this as a constructive contribution,
270
+ not an attack. **Never ignore these requests** — reviewer engagement is a positive signal.
271
+
272
+ ### Category 5: Statistical Method Challenge
273
+
274
+ Reviewer questions or requests changes to statistical methods.
275
+ **Response**: Consult a biostatistician if unfamiliar → provide a reasoned justification
276
+ for your method choice with references → if the reviewer's suggestion is valid, perform
277
+ both analyses and show results are consistent. "This analysis was reviewed in consultation
278
+ with our biostatistician" adds credibility.
279
+
280
+ ### Mapping to MAJ/MIN/REB
281
+
282
+ | Category | Typical Classification |
283
+ |----------|----------------------|
284
+ | 1. Simple Question | MIN |
285
+ | 2. Misunderstanding | MIN or REB |
286
+ | 3. Further Discussion | MIN (if text change) or REB (if disagree) |
287
+ | 4. Additional Results | MAJ |
288
+ | 5. Statistical Challenge | MAJ |
289
+
290
+ Use the 5-category triage to inform the MAJ/MIN/REB classification in Step 1, not replace it.
291
+
292
+ ---
293
+
294
+ ## Handling Low-Quality Reviews
295
+
296
+ Reviewer quality varies widely. When facing comments that suggest the reviewer did not
297
+ carefully read the manuscript:
298
+
299
+ 1. **Do not get combative.** Respond with the same professionalism regardless of review quality.
300
+ 2. **Address every point**, even trivial or off-topic ones. Skipping a comment signals
301
+ disrespect to the editor.
302
+ 3. **For irrelevant comments**: Add a clarifying sentence to Discussion or Methods, and
303
+ reply: "We have added clarification in [section] to address this concern." This shows
304
+ effort without conceding a scientific point.
305
+ 4. **For factually incorrect comments**: Provide evidence (with references) politely.
306
+ Frame as "We believe there may be a misunderstanding" rather than "The reviewer is wrong."
307
+ 5. **Remember the audience**: The response letter is read by the editor, not just the
308
+ reviewer. A measured, thorough response demonstrates manuscript quality even when
309
+ the review does not.
310
+
311
+ ---
312
+
313
+ ## Response-Letter Voice & AI-Tell Avoidance
314
+
315
+ A response-to-reviewers letter is a reviewer-facing scientific argument, not an internal
316
+ change-log. The dominant AI-tell in machine-drafted letters is the **editing-mechanism
317
+ register**: prose that narrates *how the text was edited* ("the revised Methods adds one
318
+ sentence at line 88", "a grep-and-soften pass replaced six phrases", "no further manuscript
319
+ change") instead of stating, in plain language, what changed and why.
320
+
321
+ Three principles when drafting (the AI-tell patterns themselves are defined once in humanize
322
+ `references/ai_patterns.md`, patterns 22-24 — this section is the authoring guidance):
323
+
324
+ 1. **Write the change and the science, not the editing mechanism.** Describe what changed and
325
+ why, and quote the new sentence. Never narrate the diff: no version prefixes ("v2 adds..."),
326
+ no "softened N phrases", no grep/verification language, no internal FIX codes, no bare "No
327
+ further manuscript change" stubs. Describing a *new analysis you ran* ("we performed a
328
+ sensitivity analysis and found X") is the science, not a tell — that is welcome.
329
+ 2. **No `§` symbols, no internal draft line numbers.** A revised-manuscript page/line
330
+ ("page 7, lines 177-178", stated once as referring to the revised manuscript) is fine;
331
+ only internal draft line numbers that will not match the reviewer's view are banned.
332
+ 3. **Format is free.** Free prose, a structured `Response:` / `Changes made:` block, an
333
+ `Original → Revised` pair, or a left-comment/right-response table are all standard human
334
+ conventions. Pick any; strip only the mechanism narration.
335
+
336
+ ### Reviewer-facing tone
337
+
338
+ - **Vary openers.** "We thank the reviewer for this point." / "We agree." / "This is an important concern." / "We have addressed this as follows." Do not repeat one acknowledgment sentence down the whole letter.
339
+ - **Calibrate the stance**: full agreement, partial agreement with a bounded clarification, or a polite, evidence-backed rebuttal. Match the register to the substance.
340
+ - **Admit error plainly** when the reviewer is right ("The reviewer is correct; we have corrected this.") — natural humility reads as human and builds editor trust.
341
+ - **Quote the new manuscript text** verbatim in quotation marks, then name its section — what experienced authors do, and the single strongest human signal across real letters.
342
+
343
+ ### Succinctness & non-defensiveness (especially R2+)
344
+
345
+ Let the point-by-point prove the work; strip the pre-emptive defence. This matters most on **R2+ rounds**, where over-explaining reads as anxiety rather than rigor.
346
+
347
+ - **No pre-emptive hand-holding.** Drop "Reviewers 2 and 3 also accepted this," "we left it unchanged because the other reviewers were satisfied," and similar cross-reviewer lobbying. Answer the comment in front of you.
348
+ - **A satisfied reviewer gets one sentence.** If a reviewer is content or offers only praise, "We thank the reviewer." or a single sentence is the whole response. Do not manufacture paragraphs.
349
+ - **Cut defensive meta-comments.** Remove "We confirm this statement is unchanged and not softened," "These passages already make the point, so no further text was added." State plainly where the matter is handled and move on.
350
+ - **Fold methodology disclosure into the comment it answers.** Multiplicity, a SAP deviation, or an analysis caveat goes inside the relevant response — not into a separate "Statistical note" front section. Keep the disclosure (never hide a deviation), but keep it in place.
351
+ - **Split, do not bundle.** When a reviewer packs several points into one paragraph, answer each as its own comment with that reviewer sentence quoted, not one block reply to the whole paragraph. Succinct means short *answers*, not fewer *comments*.
352
+
353
+ See `${CLAUDE_SKILL_DIR}/references/r2r_voice.md` for the before/after gallery, response
354
+ skeletons, and the meta-phrase conversion table.
355
+
356
+ ### Mandatory pre-submission scan
357
+
358
+ Before circulating or uploading the response letter and cover letter, run `/humanize` on
359
+ **both documents**. The R2R AI-tell patterns (22-24) are defined in humanize
360
+ `references/ai_patterns.md`; together with 13 (em dash), 16 (filler), and 19 (`§`) they form
361
+ the response-letter scan. Also apply `~/.claude/rules/manuscript-style-classical.md` (`§`,
362
+ em-dash, heading discipline) — the same senior-reviewer red flags apply to the letter.
363
+
364
+ ---
365
+
366
+ ## Step 5: Cover Letter to Editor
367
+
368
+ **Output location:** `revision/R[N]/cover_letter_R[N].md`
369
+
370
+ ```
371
+ [Date]
372
+
373
+ Dear Dr. [Editor Name / "Editor-in-Chief"],
374
+
375
+ Thank you for the opportunity to revise our manuscript, "[Full title]"
376
+ (Manuscript ID: XXXX), submitted to [Journal Name]. We have carefully
377
+ reviewed the comments from the Editor and reviewers and have revised
378
+ the manuscript accordingly.
379
+
380
+ In brief, the principal changes in this revision are: [1) ..., 2) ...,
381
+ 3) ...]. A point-by-point response to each comment is provided in the
382
+ accompanying Response to Reviewers document. Revised sections are
383
+ highlighted in yellow in the manuscript.
384
+
385
+ We believe the revised manuscript addresses all concerns raised in the
386
+ review and is now suitable for publication in [Journal Name].
387
+
388
+ Sincerely,
389
+
390
+ [First Author Name], MD/PhD
391
+ [Institution]
392
+ [Email]
393
+ On behalf of all authors
394
+ ```
395
+
396
+ ### R1 vs R2+ cover-letter protocol
397
+
398
+ The template above is the **R1** convention: a standalone editor cover letter (200-400 words).
399
+
400
+ On an **R2+ round (second revision onward), do not write a separate cover letter.** Whatever you would say to the editor — the greeting and the brief change summary — belongs in the **head of the response-to-reviewers letter**, not in a second document. A standalone cover letter that merely restates the response letter's summary reads as redundant and, on later rounds, as boilerplate. If an earlier round already produced a `cover_letter_R1.md`, move it to `_superseded/`, exclude it from the R2+ package, and reuse the response-letter head verbatim in any portal "cover letter" field. (Exception: a journal that explicitly requires a separate cover letter at every round — then keep the head summary and the cover letter from duplicating each other.)
401
+
402
+ **Response-letter head (R2+)** — placed at the top of `response_to_reviewers_R[N].md`, before the point-by-point:
403
+
404
+ ```
405
+ Dear Dr. [Editor Name / "Editor-in-Chief"],
406
+
407
+ Thank you for the opportunity to revise our manuscript once more. In brief, this
408
+ revision [1-2 sentence summary of the principal changes — e.g., "adds the requested
409
+ subgroup analysis and tempers the three comparisons the reviewers flagged as
410
+ over-stated"].
411
+
412
+ [If applicable: one sentence on a companion paper, a re-analysis, or a verification
413
+ the editor requested.]
414
+
415
+ All quotations below are from the revised manuscript. A point-by-point response to each
416
+ comment follows.
417
+
418
+ Sincerely,
419
+ [First Author Name], on behalf of all authors
420
+ ```
421
+
422
+ Keep the head to a short greeting, a one-paragraph "in brief," an optional companion/verification note, the single line stating quotations are from the revised manuscript, and the signature. Everything else is point-by-point.
423
+
424
+ ---
425
+
426
+ ## Step 6: Change Log
427
+
428
+ **Output location:** `revision/R[N]/change_log_R[N].md`
429
+
430
+ | Comment | Type | Change Made | Section | Page | Lines |
431
+ |---------|------|-------------|---------|------|-------|
432
+ | R1-1 | MAJ | Added subgroup analysis by scanner type | Results 4.3, Table 3 | 12 | 234-251 |
433
+ | R1-2 | MIN | Clarified exclusion criteria for motion artifact | Methods 2.2 | 6 | 112-115 |
434
+
435
+ ---
436
+
437
+ ## Step 7: Final Verification
438
+
439
+ After all responses are drafted, check:
440
+
441
+ - [ ] Every reviewer comment has a response (none skipped)
442
+ - [ ] Every MAJOR comment has a corresponding manuscript change with location
443
+ - [ ] Every REBUTTAL is backed by cited evidence or clear scientific reasoning
444
+ - [ ] All new statistics include 95% CI and exact p-values
445
+ - [ ] Page/line number references match the revised manuscript (not the original)
446
+ - [ ] No internal draft line numbers ("(line 43)"); locations point to section names or revised-manuscript page/line
447
+ - [ ] No `§` symbols and no editing-mechanism narration ("v2 adds one sentence", "grep verification", "No further manuscript change")
448
+ - [ ] Acknowledgment openers varied (not one sentence repeated across responses)
449
+ - [ ] Response letter AND cover letter ran through `/humanize` (patterns 22-24 triage hits reviewed; confirmed instances = 0; `§` = 0 hard)
450
+ - [ ] (R2+) No separate cover letter — the editor greeting and "in brief" summary are folded into the response-letter head
451
+ - [ ] (R2+) Satisfied reviewers get ≤1-2 sentences; no pre-emptive hand-holding or cross-reviewer lobbying
452
+ - [ ] Multi-point reviewer paragraphs are split into discrete comments (reviewer sentence quoted + Response N), not answered as a block
453
+ - [ ] Methodology disclosure (multiplicity, SAP deviation) is folded into the relevant response, not a separate front section
454
+ - [ ] Cover letter is addressed to the correct editor
455
+ - [ ] Response letter is 5000-8000 words
456
+ - [ ] Tracked changes are enabled in the revised manuscript
457
+ - [ ] All new figures/tables are referenced in the response letter
458
+
459
+ ---
460
+
461
+ ## Revision Round File Structure
462
+
463
+ | Round | Folder | Files |
464
+ |-------|--------|-------|
465
+ | R1 | `revision/R1/` | `response_to_reviewers_R1.md`, `cover_letter_R1.md`, `change_log_R1.md` |
466
+ | R2 | `revision/R2/` | `response_to_reviewers_R2.md`, `cover_letter_R2.md`, `change_log_R2.md` |
467
+
468
+ Revised manuscript: `paper/main_revised_R[N].tex` (or `.qmd`)
469
+
470
+ For R2+, acknowledge whether R1 concerns were fully resolved. If a reviewer raises a new concern at R2, note: "This comment was not raised in the first review round; we address it as follows."
471
+
472
+ ---
473
+
474
+ ## Word Count Guidance
475
+
476
+ - Response letter total: 5000-8000 words (including quoted reviewer comments)
477
+ - Cover letter: 200-400 words (R1 only; on R2+ there is no separate cover letter — see Step 5)
478
+ - MINOR response: 50-150 words
479
+ - MAJOR response: 150-400 words
480
+ - REBUTTAL response: 200-500 words
481
+ - **R2+ rounds run leaner.** Most R1 concerns are already resolved, so the letter is shorter and a satisfied reviewer's response is 1-2 sentences. Do not pad an R2+ reply to reach the R1 range.
482
+
483
+ ---
484
+
485
+ ## Common Mistakes to Avoid
486
+
487
+ 1. Do not agree with every MAJOR comment without providing the actual new data or analysis.
488
+ 2. Do not write vague responses ("We have revised the text accordingly") without specifying what changed and where.
489
+ 3. Do not skip any comment, even if trivial or addressed elsewhere.
490
+ 4. Do not reference page/line numbers from the original manuscript; use the revised version.
491
+ 5. Do not begin a rebuttal aggressively; always open with acknowledgment.
492
+ 6. Do not promise changes that were not actually made.
493
+ 7. Do not forget to renumber figures and tables if new items were inserted.
494
+
495
+ ## Anti-Hallucination
496
+
497
+ - **Never fabricate references.** All citations must be verified via `/search-lit` with confirmed DOI or PMID. Mark unverified references as `[UNVERIFIED - NEEDS MANUAL CHECK]`.
498
+ - **Never invent clinical definitions, diagnostic criteria, or guideline recommendations.** If uncertain, flag with `[VERIFY]` and ask the user.
499
+ - **Never fabricate numerical results** — compliance percentages, scores, effect sizes, or sample sizes must come from actual data or analysis output.
500
+ - If a reporting guideline item, journal policy, or clinical standard is uncertain, state the uncertainty rather than guessing.
501
+
502
+ ---
503
+
504
+ ## Gates
505
+
506
+ | Gate | Severity | Trigger | Action on fail |
507
+ |---|---|---|---|
508
+ | Comment classification (MAJOR / MINOR / REBUTTAL) | ENFORCED | comment unclassified or classification disputed | ask user; do not silently default |
509
+ | Step 2.5 `[VERIFY-CSV]` tagging on revision-introduced numbers | ENFORCED | new numerical claim added without `[VERIFY-CSV]` tag | tag automatically; HALT until CSV cross-check completes |
510
+ | Reference re-render after revisions touching citations | ENFORCED | any new `[@bibkey]` added in R1+ | route to `/manage-refs` Phase 7.6 re-render before R1 submission |
511
+ | `/verify-refs --strict` post-revision | ENFORCED | FABRICATED / HIGH_MISMATCH_FIRST_AUTHOR > 0 | HALT R1 submission |
512
+ | New analysis coordination | ENFORCED | reviewer asks for new analysis | route to `/analyze-stats` (and `/make-figures` if figure changes); never hand-write new numbers |
513
+ | Cover letter to editor | ENFORCED at R1 submission | R1 missing editor cover letter | block submission |
514
+ | R2+ cover-letter handling | ENFORCED at R2+ submission | standalone cover letter present on an R2+ round (not folded into the response-letter head) | move it to `_superseded/`; fold the summary into the head |
515
+ | Response-letter voice / AI-tell | ENFORCED before submission | editing-mechanism narration, internal draft line refs, `§`, tooling leak, or repeated openers in response/cover letter | run `/humanize` (patterns 22-24 as triage; `§` = 0 hard); resolve confirmed tells before submission |