@nfdi4plants/arctrl 3.1.1 → 3.2.0

package/dist/ts/ts/Core/ArcTypes.js

@@ -1,21 +1,21 @@
-import { defaultArg, unwrap, value, map } from '../../node_modules/@fable-org/fable-library-js/Option.js';
-import { toArray, filter, contains, forAll, fold, length, toList, delay, map as map$1, item, choose, exists, tryFindIndex, iterate, removeAt, tryFind, append, collect } from '../../node_modules/@fable-org/fable-library-js/Seq.js';
-import { stringHash, getEnumerator, safeHash, equals, disposeSafe, defaultOf } from '../../node_modules/@fable-org/fable-library-js/Util.js';
+import { defaultArg, unwrap, value } from '../../node_modules/@fable-org/fable-library-ts/Option.js';
+import { toArray, filter, contains, forAll, fold, length, toList, delay, map, item, choose, exists, tryFindIndex, iterate, removeAt, tryFind, append, collect } from '../../node_modules/@fable-org/fable-library-ts/Seq.js';
+import { stringHash, getEnumerator, safeHash, equals, disposeSafe, Exception, defaultOf } from '../../node_modules/@fable-org/fable-library-ts/Util.js';
 import { ResizeArray_map, ResizeArray_filter, ResizeArray_choose } from './Helper/Collections.js';
-import { contains as contains$1, removeInPlace, addRangeInPlace } from '../../node_modules/@fable-org/fable-library-js/Array.js';
-import { toText, printf } from '../../node_modules/@fable-org/fable-library-js/String.js';
-import { rangeDouble } from '../../node_modules/@fable-org/fable-library-js/Range.js';
+import { contains as contains$1, removeInPlace, setItem, item as item$1, addRangeInPlace } from '../../node_modules/@fable-org/fable-library-ts/Array.js';
+import { toText, printf, concat } from '../../node_modules/@fable-org/fable-library-ts/String.js';
+import { rangeDouble } from '../../node_modules/@fable-org/fable-library-ts/Range.js';
 import { boxHashArray, boxHashOption, boxHashSeq } from './Helper/HashCodes.js';
 import { checkValidCharacters } from './Helper/Identifier.js';
 import { ArcTables, ArcTables_$reflection, ArcTablesAux_getIOMap, ArcTablesAux_applyIOMap } from './Table/ArcTables.js';
-import { class_type } from '../../node_modules/@fable-org/fable-library-js/Reflection.js';
-import { Array_distinct } from '../../node_modules/@fable-org/fable-library-js/Seq2.js';
-import { FSharpRef } from '../../node_modules/@fable-org/fable-library-js/Types.js';
+import { class_type } from '../../node_modules/@fable-org/fable-library-ts/Reflection.js';
+import { Array_distinct } from '../../node_modules/@fable-org/fable-library-ts/Seq2.js';
+import { FSharpRef } from '../../node_modules/@fable-org/fable-library-ts/Types.js';
 
 class ArcAssay extends ArcTables {
   constructor(identifier, title, description, measurementType, technologyType, technologyPlatform, tables, datamap, performers, comments) {
     super(defaultArg(tables, []));
-    let identifier_1;
+    let identifier_1 = void 0;
     const performers_1 = defaultArg(performers, []);
     const comments_1 = defaultArg(comments, []);
     this["identifier@129"] = (identifier_1 = identifier.trim(), checkValidCharacters(identifier_1), identifier_1);
@@ -30,10 +30,16 @@ class ArcAssay extends ArcTables {
     this["comments@141-1"] = comments_1;
     this.staticHash = 0;
   }
+  /**
+   * Must be unique in one study
+   */
   get Identifier() {
     const this$ = this;
     return this$["identifier@129"];
   }
+  /**
+   * Must be unique in one study
+   */
   set Identifier(i) {
     const this$ = this;
     this$["identifier@129"] = i;
@@ -141,7 +147,7 @@ class ArcAssay extends ArcTables {
         const source = s.RegisteredAssayIdentifiers;
         return contains(this$.Identifier, source, {
           Equals: (x, y) => x === y,
-          GetHashCode: stringHash
+          GetHashCode: (x) => stringHash(x) | 0
         });
       }, i.Studies));
     }
@@ -173,12 +179,18 @@ class ArcAssay extends ArcTables {
       return c;
     };
   }
+  /**
+   * Receive **copy** of table at `index`
+   */
   static getTableAt(index) {
     return (assay) => {
       const newAssay = assay.Copy();
       return newAssay.GetTableAt(index);
     };
   }
+  /**
+   * Receive **copy** of table with `name` = `ArcTable.Name`
+   */
   static getTable(name) {
     return (assay) => {
       const newAssay = assay.Copy();
@@ -368,10 +380,13 @@ class ArcAssay extends ArcTables {
     return assay;
   }
   Copy() {
+    let d = void 0;
     const this$ = this;
     const nextTables = ResizeArray_map((c) => c.Copy(), this$.Tables);
     const nextComments = ResizeArray_map((c_1) => c_1.Copy(), this$.Comments);
-    const nextDatamap = map((d) => d.Copy(), this$.Datamap);
+    let nextDatamap;
+    const option_1 = this$.Datamap;
+    nextDatamap = option_1 != null ? (d = value(option_1), d.Copy()) : void 0;
     const nextPerformers = ResizeArray_map((c_2) => c_2.Copy(), this$.Performers);
     const identifier = this$.Identifier;
     const title = this$.Title;
@@ -381,6 +396,9 @@ class ArcAssay extends ArcTables {
     const technologyPlatform = this$.TechnologyPlatform;
     return ArcAssay.make(identifier, title, description, measurementType, technologyType, technologyPlatform, nextTables, nextDatamap, nextPerformers, nextComments);
   }
+  /**
+   * Updates given assay with another assay, Identifier will never be updated. By default update is full replace. Optional Parameters can be used to specify update logic.
+   */
   UpdateBy(assay, onlyReplaceExisting, appendSequences) {
     const this$ = this;
     const onlyReplaceExisting_1 = defaultArg(onlyReplaceExisting, false);
@@ -415,7 +433,7 @@ class ArcAssay extends ArcTables {
             const e = enumerator["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e, combined, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_1) => safeHash(x_1) | 0
             })) {
               void combined.push(e);
             }
@@ -429,7 +447,7 @@ class ArcAssay extends ArcTables {
             const e_1 = enumerator_1["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_1, combined, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_2) => safeHash(x_2) | 0
             })) {
               void combined.push(e_1);
             }
@@ -455,7 +473,7 @@ class ArcAssay extends ArcTables {
             const e_2 = enumerator_2["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_2, combined_1, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_4) => safeHash(x_4) | 0
             })) {
               void combined_1.push(e_2);
             }
@@ -469,7 +487,7 @@ class ArcAssay extends ArcTables {
             const e_1_1 = enumerator_1_1["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_1_1, combined_1, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_5) => safeHash(x_5) | 0
             })) {
               void combined_1.push(e_1_1);
             }
@@ -495,7 +513,7 @@ class ArcAssay extends ArcTables {
             const e_3 = enumerator_3["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_3, combined_2, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_7) => safeHash(x_7) | 0
             })) {
               void combined_2.push(e_3);
             }
@@ -509,7 +527,7 @@ class ArcAssay extends ArcTables {
             const e_1_2 = enumerator_1_2["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_1_2, combined_2, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_8) => safeHash(x_8) | 0
             })) {
               void combined_2.push(e_1_2);
             }
@@ -543,6 +561,9 @@ class ArcAssay extends ArcTables {
     const this$ = this;
     this$.Investigation = void 0;
   }
+  /**
+   * Updates given assay stored in an study or investigation file with values from an assay file.
+   */
   UpdateReferenceByAssayFile(assay, onlyReplaceExisting) {
     const this$ = this;
     const updateAlways = !defaultArg(onlyReplaceExisting, false);
@@ -573,7 +594,7 @@ class ArcAssay extends ArcTables {
     }
   }
   StructurallyEquals(other) {
-    let a, b, a_1, b_1, a_2, b_2;
+    let a = void 0, b = void 0, a_1 = void 0, b_1 = void 0, a_2 = void 0, b_2 = void 0;
     const this$ = this;
     return forAll((x) => x === true, [this$.Identifier === other.Identifier, equals(this$.Title, other.Title), equals(this$.Description, other.Description), equals(this$.MeasurementType, other.MeasurementType), equals(this$.TechnologyType, other.TechnologyType), equals(this$.TechnologyPlatform, other.TechnologyPlatform), equals(this$.Datamap, other.Datamap), (a = this$.Tables, b = other.Tables, length(a) === length(b) && fold((acc, e) => {
       if (acc) {
@@ -581,26 +602,31 @@ class ArcAssay extends ArcTables {
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_1) => equals(item(i_1, a), item(i_1, b)), rangeDouble(0, 1, length(a) - 1)))))), (a_1 = this$.Performers, b_1 = other.Performers, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
+    }, true, toList(delay(() => map((i_1) => equals(item(i_1, a), item(i_1, b)), rangeDouble(0, 1, length(a) - 1)))))), (a_1 = this$.Performers, b_1 = other.Performers, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
       if (acc_1) {
         return e_1;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.Comments, b_2 = other.Comments, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
+    }, true, toList(delay(() => map((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.Comments, b_2 = other.Comments, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
       if (acc_2) {
         return e_2;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1))))))]);
+    }, true, toList(delay(() => map((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1))))))]);
   }
+  /**
+   * Use this function to check if this ArcAssay and the input ArcAssay refer to the same object.
+   * 
+   * If true, updating one will update the other due to mutability.
+   */
   ReferenceEquals(other) {
     const this$ = this;
     return this$ === other;
   }
   Equals(other) {
-    let assay;
+    let assay = void 0;
     const this$ = this;
     return other instanceof ArcAssay && (assay = other, this$.StructurallyEquals(assay));
   }
@@ -622,33 +648,39 @@ function ArcAssay_$ctor_Z69B192EC(identifier, title, description, measurementTyp
 class ArcStudy extends ArcTables {
   constructor(identifier, title, description, submissionDate, publicReleaseDate, publications, contacts, studyDesignDescriptors, tables, datamap, registeredAssayIdentifiers, comments) {
     super(defaultArg(tables, []));
-    let identifier_1;
+    let identifier_1 = void 0;
     const publications_1 = defaultArg(publications, []);
     const contacts_1 = defaultArg(contacts, []);
     const studyDesignDescriptors_1 = defaultArg(studyDesignDescriptors, []);
     const registeredAssayIdentifiers_1 = defaultArg(registeredAssayIdentifiers, []);
     const comments_1 = defaultArg(comments, []);
-    this["identifier@579"] = (identifier_1 = identifier.trim(), checkValidCharacters(identifier_1), identifier_1);
+    this["identifier@582"] = (identifier_1 = identifier.trim(), checkValidCharacters(identifier_1), identifier_1);
     this.investigation = void 0;
-    this["title@584"] = title;
-    this["description@585"] = description;
-    this["submissionDate@586"] = submissionDate;
-    this["publicReleaseDate@587"] = publicReleaseDate;
-    this["publications@588-1"] = publications_1;
-    this["contacts@589-1"] = contacts_1;
-    this["studyDesignDescriptors@590-1"] = studyDesignDescriptors_1;
-    this["datamap@591"] = datamap;
-    this["registeredAssayIdentifiers@592-1"] = registeredAssayIdentifiers_1;
-    this["comments@593-1"] = comments_1;
+    this["title@587"] = title;
+    this["description@588"] = description;
+    this["submissionDate@589"] = submissionDate;
+    this["publicReleaseDate@590"] = publicReleaseDate;
+    this["publications@591-1"] = publications_1;
+    this["contacts@592-1"] = contacts_1;
+    this["studyDesignDescriptors@593-1"] = studyDesignDescriptors_1;
+    this["datamap@594"] = datamap;
+    this["registeredAssayIdentifiers@595-1"] = registeredAssayIdentifiers_1;
+    this["comments@596-1"] = comments_1;
     this.staticHash = 0;
   }
+  /**
+   * Must be unique in one investigation
+   */
   get Identifier() {
     const this$ = this;
-    return this$["identifier@579"];
+    return this$["identifier@582"];
   }
+  /**
+   * Must be unique in one investigation
+   */
   set Identifier(i) {
     const this$ = this;
-    this$["identifier@579"] = i;
+    this$["identifier@582"] = i;
   }
   get Investigation() {
     const this$ = this;
@@ -660,83 +692,83 @@ class ArcStudy extends ArcTables {
   }
   get Title() {
     const this$ = this;
-    return unwrap(this$["title@584"]);
+    return unwrap(this$["title@587"]);
   }
   set Title(n) {
     const this$ = this;
-    this$["title@584"] = n;
+    this$["title@587"] = n;
   }
   get Description() {
     const this$ = this;
-    return unwrap(this$["description@585"]);
+    return unwrap(this$["description@588"]);
   }
   set Description(n) {
     const this$ = this;
-    this$["description@585"] = n;
+    this$["description@588"] = n;
   }
   get SubmissionDate() {
     const this$ = this;
-    return unwrap(this$["submissionDate@586"]);
+    return unwrap(this$["submissionDate@589"]);
   }
   set SubmissionDate(n) {
     const this$ = this;
-    this$["submissionDate@586"] = n;
+    this$["submissionDate@589"] = n;
   }
   get PublicReleaseDate() {
     const this$ = this;
-    return unwrap(this$["publicReleaseDate@587"]);
+    return unwrap(this$["publicReleaseDate@590"]);
   }
   set PublicReleaseDate(n) {
     const this$ = this;
-    this$["publicReleaseDate@587"] = n;
+    this$["publicReleaseDate@590"] = n;
   }
   get Publications() {
     const this$ = this;
-    return this$["publications@588-1"];
+    return this$["publications@591-1"];
   }
   set Publications(n) {
     const this$ = this;
-    this$["publications@588-1"] = n;
+    this$["publications@591-1"] = n;
   }
   get Contacts() {
     const this$ = this;
-    return this$["contacts@589-1"];
+    return this$["contacts@592-1"];
   }
   set Contacts(n) {
     const this$ = this;
-    this$["contacts@589-1"] = n;
+    this$["contacts@592-1"] = n;
   }
   get StudyDesignDescriptors() {
     const this$ = this;
-    return this$["studyDesignDescriptors@590-1"];
+    return this$["studyDesignDescriptors@593-1"];
   }
   set StudyDesignDescriptors(n) {
     const this$ = this;
-    this$["studyDesignDescriptors@590-1"] = n;
+    this$["studyDesignDescriptors@593-1"] = n;
   }
   get Datamap() {
     const this$ = this;
-    return unwrap(this$["datamap@591"]);
+    return unwrap(this$["datamap@594"]);
   }
   set Datamap(n) {
     const this$ = this;
-    this$["datamap@591"] = n;
+    this$["datamap@594"] = n;
   }
   get RegisteredAssayIdentifiers() {
     const this$ = this;
-    return this$["registeredAssayIdentifiers@592-1"];
+    return this$["registeredAssayIdentifiers@595-1"];
   }
   set RegisteredAssayIdentifiers(n) {
     const this$ = this;
-    this$["registeredAssayIdentifiers@592-1"] = n;
+    this$["registeredAssayIdentifiers@595-1"] = n;
   }
   get Comments() {
     const this$ = this;
-    return this$["comments@593-1"];
+    return this$["comments@596-1"];
   }
   set Comments(n) {
     const this$ = this;
-    this$["comments@593-1"] = n;
+    this$["comments@596-1"] = n;
   }
   get StaticHash() {
     const this$ = this;
@@ -755,6 +787,9 @@ class ArcStudy extends ArcTables {
   static make(identifier, title, description, submissionDate, publicReleaseDate, publications, contacts, studyDesignDescriptors, tables, datamap, registeredAssayIdentifiers, comments) {
     return new ArcStudy(identifier, unwrap(title), unwrap(description), unwrap(submissionDate), unwrap(publicReleaseDate), publications, contacts, studyDesignDescriptors, tables, unwrap(datamap), registeredAssayIdentifiers, comments);
   }
+  /**
+   * Returns true if all fields are None/ empty sequences **except** Identifier.
+   */
   get isEmpty() {
     const this$ = this;
     return equals(this$.Title, void 0) && equals(this$.Description, void 0) && equals(this$.SubmissionDate, void 0) && equals(this$.PublicReleaseDate, void 0) && this$.Publications.length === 0 && this$.Contacts.length === 0 && this$.StudyDesignDescriptors.length === 0 && this$.Tables.length === 0 && this$.RegisteredAssayIdentifiers.length === 0 && this$.Comments.length === 0;
@@ -762,14 +797,23 @@ class ArcStudy extends ArcTables {
   static get FileName() {
     return "isa.study.xlsx";
   }
+  /**
+   * Returns the count of registered assay *identifiers*. This is not necessarily the same as the count of registered assays, as not all identifiers correspond to an existing assay.
+   */
   get RegisteredAssayIdentifierCount() {
     const this$ = this;
     return this$.RegisteredAssayIdentifiers.length | 0;
   }
+  /**
+   * Returns the count of registered assays. This is not necessarily the same as the count of registered assay *identifiers*, as not all identifiers correspond to an existing assay.
+   */
   get RegisteredAssayCount() {
     const this$ = this;
     return this$.RegisteredAssays.length | 0;
   }
+  /**
+   * Returns all assays registered in this study, that correspond to an existing assay object in the associated investigation.
+   */
   get RegisteredAssays() {
     const this$ = this;
     let inv;
@@ -777,11 +821,14 @@ class ArcStudy extends ArcTables {
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     const collection = choose((assayIdentifier) => inv.TryGetAssay(assayIdentifier), this$.RegisteredAssayIdentifiers);
     return Array.from(collection);
   }
+  /**
+   * Returns all registered assay identifiers that do not correspond to an existing assay object in the associated investigation.
+   */
   get VacantAssayIdentifiers() {
     const this$ = this;
     let inv;
@@ -789,11 +836,14 @@ class ArcStudy extends ArcTables {
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     const collection = filter((arg) => !inv.ContainsAssay(arg), this$.RegisteredAssayIdentifiers);
     return Array.from(collection);
   }
+  /**
+   * Add assay to investigation and register it to study.
+   */
   AddRegisteredAssay(assay) {
     const this$ = this;
     let inv;
@@ -801,7 +851,7 @@ class ArcStudy extends ArcTables {
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     inv.AddAssay(assay);
     inv.RegisterAssay(this$.Identifier, assay.Identifier);
@@ -829,9 +879,9 @@ class ArcStudy extends ArcTables {
     const this$ = this;
     if (contains(assayIdentifier, this$.RegisteredAssayIdentifiers, {
       Equals: (x, y) => x === y,
-      GetHashCode: stringHash
+      GetHashCode: (x) => stringHash(x) | 0
     })) {
-      throw new Error(`Assay \`${assayIdentifier}\` is already registered on the study.`);
+      throw new Exception(concat("Assay `", assayIdentifier, "` is already registered on the study."));
     }
     void this$.RegisteredAssayIdentifiers.push(assayIdentifier);
   }
@@ -846,7 +896,7 @@ class ArcStudy extends ArcTables {
     const this$ = this;
     removeInPlace(assayIdentifier, this$.RegisteredAssayIdentifiers, {
       Equals: (x, y) => x === y,
-      GetHashCode: stringHash
+      GetHashCode: (x) => stringHash(x) | 0
     });
   }
   static deregisterAssay(assayIdentifier) {
@@ -860,16 +910,16 @@ class ArcStudy extends ArcTables {
     const this$ = this;
     if (!contains(assayIdentifier, this$.RegisteredAssayIdentifiers, {
       Equals: (x, y) => x === y,
-      GetHashCode: stringHash
+      GetHashCode: (x) => stringHash(x) | 0
     })) {
-      throw new Error(`Assay \`${assayIdentifier}\` is not registered on the study.`);
+      throw new Exception(concat("Assay `", assayIdentifier, "` is not registered on the study."));
     }
     let inv;
     const investigation = this$.Investigation;
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     return inv.GetAssay(assayIdentifier);
   }
@@ -885,6 +935,9 @@ class ArcStudy extends ArcTables {
       return copy.RegisteredAssays;
     };
   }
+  /**
+   * Returns ArcAssays registered in study, or if no parent exists, initializies new ArcAssay from identifier.
+   */
   GetRegisteredAssaysOrIdentifier() {
     const this$ = this;
     const matchValue = this$.Investigation;
@@ -902,6 +955,9 @@ class ArcStudy extends ArcTables {
       }, this$.RegisteredAssayIdentifiers);
     }
   }
+  /**
+   * Returns ArcAssays registered in study, or if no parent exists, initializies new ArcAssay from identifier.
+   */
   static getRegisteredAssaysOrIdentifier() {
     return (study) => {
       const copy = study.Copy();
@@ -935,12 +991,18 @@ class ArcStudy extends ArcTables {
       return c;
     };
   }
+  /**
+   * Receive **copy** of table at `index`
+   */
   static getTableAt(index) {
     return (study) => {
       const newAssay = study.Copy();
       return newAssay.GetTableAt(index);
     };
   }
+  /**
+   * Receive **copy** of table with `name` = `ArcTable.Name`
+   */
   static getTable(name) {
     return (study) => {
       const newAssay = study.Copy();
@@ -1133,7 +1195,15 @@ class ArcStudy extends ArcTables {
     const this$ = this;
     this$.Investigation = void 0;
   }
+  /**
+   * Copies ArcStudy object without the pointer to the parent ArcInvestigation
+   * 
+   * This copy does only contain the identifiers of the registered ArcAssays and not the actual objects.
+   * 
+   * In order to copy the ArcAssays as well, use the Copy() method of the ArcInvestigation.
+   */
   Copy(copyInvestigationRef) {
+    let d = void 0;
     const this$ = this;
     const copyInvestigationRef_1 = defaultArg(copyInvestigationRef, false);
     const nextTables = [];
@@ -1152,7 +1222,9 @@ class ArcStudy extends ArcTables {
     const nextContacts = ResizeArray_map((c_1) => c_1.Copy(), this$.Contacts);
     const nextPublications = ResizeArray_map((c_2) => c_2.Copy(), this$.Publications);
     const nextStudyDesignDescriptors = ResizeArray_map((c_3) => c_3.Copy(), this$.StudyDesignDescriptors);
-    const nextDatamap = map((d) => d.Copy(), this$.Datamap);
+    let nextDatamap;
+    const option_1 = this$.Datamap;
+    nextDatamap = option_1 != null ? (d = value(option_1), d.Copy()) : void 0;
     let study;
     const identifier = this$.Identifier;
     const title = this$.Title;
@@ -1165,6 +1237,9 @@ class ArcStudy extends ArcTables {
     }
     return study;
   }
+  /**
+   * Updates given study from an investigation file against a study from a study file. Identifier will never be updated.
+   */
   UpdateReferenceByStudyFile(study, onlyReplaceExisting, keepUnusedRefTables) {
     const this$ = this;
     const updateAlways = !defaultArg(onlyReplaceExisting, false);
@@ -1202,7 +1277,7 @@ class ArcStudy extends ArcTables {
     }
   }
   StructurallyEquals(other) {
-    let a, b, a_1, b_1, a_2, b_2, a_3, b_3, a_4, b_4, a_5, b_5;
+    let a = void 0, b = void 0, a_1 = void 0, b_1 = void 0, a_2 = void 0, b_2 = void 0, a_3 = void 0, b_3 = void 0, a_4 = void 0, b_4 = void 0, a_5 = void 0, b_5 = void 0;
     const this$ = this;
     return forAll((x) => x === true, [this$.Identifier === other.Identifier, equals(this$.Title, other.Title), equals(this$.Description, other.Description), equals(this$.SubmissionDate, other.SubmissionDate), equals(this$.PublicReleaseDate, other.PublicReleaseDate), equals(this$.Datamap, other.Datamap), (a = this$.Publications, b = other.Publications, length(a) === length(b) && fold((acc, e) => {
       if (acc) {
@@ -1210,38 +1285,43 @@ class ArcStudy extends ArcTables {
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_1) => equals(item(i_1, a), item(i_1, b)), rangeDouble(0, 1, length(a) - 1)))))), (a_1 = this$.Contacts, b_1 = other.Contacts, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
+    }, true, toList(delay(() => map((i_1) => equals(item(i_1, a), item(i_1, b)), rangeDouble(0, 1, length(a) - 1)))))), (a_1 = this$.Contacts, b_1 = other.Contacts, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
       if (acc_1) {
         return e_1;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.StudyDesignDescriptors, b_2 = other.StudyDesignDescriptors, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
+    }, true, toList(delay(() => map((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.StudyDesignDescriptors, b_2 = other.StudyDesignDescriptors, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
       if (acc_2) {
         return e_2;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1)))))), (a_3 = this$.Tables, b_3 = other.Tables, length(a_3) === length(b_3) && fold((acc_3, e_3) => {
+    }, true, toList(delay(() => map((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1)))))), (a_3 = this$.Tables, b_3 = other.Tables, length(a_3) === length(b_3) && fold((acc_3, e_3) => {
       if (acc_3) {
         return e_3;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_4) => equals(item(i_4, a_3), item(i_4, b_3)), rangeDouble(0, 1, length(a_3) - 1)))))), (a_4 = this$.RegisteredAssayIdentifiers, b_4 = other.RegisteredAssayIdentifiers, length(a_4) === length(b_4) && fold((acc_4, e_4) => {
+    }, true, toList(delay(() => map((i_4) => equals(item(i_4, a_3), item(i_4, b_3)), rangeDouble(0, 1, length(a_3) - 1)))))), (a_4 = this$.RegisteredAssayIdentifiers, b_4 = other.RegisteredAssayIdentifiers, length(a_4) === length(b_4) && fold((acc_4, e_4) => {
       if (acc_4) {
         return e_4;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_5) => item(i_5, a_4) === item(i_5, b_4), rangeDouble(0, 1, length(a_4) - 1)))))), (a_5 = this$.Comments, b_5 = other.Comments, length(a_5) === length(b_5) && fold((acc_5, e_5) => {
+    }, true, toList(delay(() => map((i_5) => item(i_5, a_4) === item(i_5, b_4), rangeDouble(0, 1, length(a_4) - 1)))))), (a_5 = this$.Comments, b_5 = other.Comments, length(a_5) === length(b_5) && fold((acc_5, e_5) => {
       if (acc_5) {
         return e_5;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_6) => equals(item(i_6, a_5), item(i_6, b_5)), rangeDouble(0, 1, length(a_5) - 1))))))]);
+    }, true, toList(delay(() => map((i_6) => equals(item(i_6, a_5), item(i_6, b_5)), rangeDouble(0, 1, length(a_5) - 1))))))]);
   }
+  /**
+   * Use this function to check if this ArcStudy and the input ArcStudy refer to the same object.
+   * 
+   * If true, updating one will update the other due to mutability.
+   */
   ReferenceEquals(other) {
     const this$ = this;
     return this$ === other;
@@ -1262,7 +1342,7 @@ class ArcStudy extends ArcTables {
     return toText(printf("ArcStudy {\r\n    Identifier = %A,\r\n    Title = %A,\r\n    Description = %A,\r\n    SubmissionDate = %A,\r\n    PublicReleaseDate = %A,\r\n    Publications = %A,\r\n    Contacts = %A,\r\n    StudyDesignDescriptors = %A,\r\n    Tables = %A,\r\n    RegisteredAssayIdentifiers = %A,\r\n    Comments = %A,\r\n}"))(arg)(arg_1)(arg_2)(arg_3)(arg_4)(arg_5)(arg_6)(arg_7)(arg_8)(arg_9)(arg_10);
   }
   Equals(other) {
-    let s;
+    let s = void 0;
     const this$ = this;
     return other instanceof ArcStudy && (s = other, this$.StructurallyEquals(s));
   }
@@ -1283,30 +1363,36 @@ function ArcStudy_$ctor_Z273F64C5(identifier, title, description, submissionDate
 }
 class ArcWorkflow {
   constructor(identifier, title, description, workflowType, uri, version, subWorkflowIdentifiers, parameters, components, datamap, contacts, cwlDescription, comments) {
-    let identifier_1;
-    this["identifier@1151"] = (identifier_1 = identifier.trim(), checkValidCharacters(identifier_1), identifier_1);
+    let identifier_1 = void 0;
+    this["identifier@1157"] = (identifier_1 = identifier.trim(), checkValidCharacters(identifier_1), identifier_1);
     this.investigation = void 0;
-    this["title@1156"] = title;
-    this["description@1157"] = description;
-    this["subWorkflowIdentifiers@1158"] = defaultArg(subWorkflowIdentifiers, []);
-    this["workflowType@1159"] = workflowType;
-    this["uri@1160"] = uri;
-    this["version@1161"] = version;
-    this["parameters@1162"] = defaultArg(parameters, []);
-    this["components@1163"] = defaultArg(components, []);
-    this["datamap@1164"] = datamap;
-    this["contacts@1165"] = defaultArg(contacts, []);
-    this["cwlDescription@1166"] = cwlDescription;
-    this["comments@1167"] = defaultArg(comments, []);
+    this["title@1162"] = title;
+    this["description@1163"] = description;
+    this["subWorkflowIdentifiers@1164"] = defaultArg(subWorkflowIdentifiers, []);
+    this["workflowType@1165"] = workflowType;
+    this["uri@1166"] = uri;
+    this["version@1167"] = version;
+    this["parameters@1168"] = defaultArg(parameters, []);
+    this["components@1169"] = defaultArg(components, []);
+    this["datamap@1170"] = datamap;
+    this["contacts@1171"] = defaultArg(contacts, []);
+    this["cwlDescription@1172"] = cwlDescription;
+    this["comments@1173"] = defaultArg(comments, []);
     this.staticHash = 0;
   }
+  /**
+   * Must be unique in one study
+   */
   get Identifier() {
     const this$ = this;
-    return this$["identifier@1151"];
+    return this$["identifier@1157"];
   }
+  /**
+   * Must be unique in one study
+   */
   set Identifier(i) {
     const this$ = this;
-    this$["identifier@1151"] = i;
+    this$["identifier@1157"] = i;
   }
   get Investigation() {
     const this$ = this;
@@ -1318,99 +1404,99 @@ class ArcWorkflow {
   }
   get Title() {
     const this$ = this;
-    return unwrap(this$["title@1156"]);
+    return unwrap(this$["title@1162"]);
   }
   set Title(t) {
     const this$ = this;
-    this$["title@1156"] = t;
+    this$["title@1162"] = t;
   }
   get Description() {
     const this$ = this;
-    return unwrap(this$["description@1157"]);
+    return unwrap(this$["description@1163"]);
   }
   set Description(d) {
     const this$ = this;
-    this$["description@1157"] = d;
+    this$["description@1163"] = d;
   }
   get SubWorkflowIdentifiers() {
     const this$ = this;
-    return this$["subWorkflowIdentifiers@1158"];
+    return this$["subWorkflowIdentifiers@1164"];
   }
   set SubWorkflowIdentifiers(s) {
     const this$ = this;
-    this$["subWorkflowIdentifiers@1158"] = s;
+    this$["subWorkflowIdentifiers@1164"] = s;
   }
   get WorkflowType() {
     const this$ = this;
-    return unwrap(this$["workflowType@1159"]);
+    return unwrap(this$["workflowType@1165"]);
   }
   set WorkflowType(w) {
     const this$ = this;
-    this$["workflowType@1159"] = w;
+    this$["workflowType@1165"] = w;
   }
   get URI() {
     const this$ = this;
-    return unwrap(this$["uri@1160"]);
+    return unwrap(this$["uri@1166"]);
   }
   set URI(u) {
     const this$ = this;
-    this$["uri@1160"] = u;
+    this$["uri@1166"] = u;
   }
   get Version() {
     const this$ = this;
-    return unwrap(this$["version@1161"]);
+    return unwrap(this$["version@1167"]);
   }
   set Version(v) {
     const this$ = this;
-    this$["version@1161"] = v;
+    this$["version@1167"] = v;
   }
   get Parameters() {
     const this$ = this;
-    return this$["parameters@1162"];
+    return this$["parameters@1168"];
   }
   set Parameters(p) {
     const this$ = this;
-    this$["parameters@1162"] = p;
+    this$["parameters@1168"] = p;
   }
   get Components() {
     const this$ = this;
-    return this$["components@1163"];
+    return this$["components@1169"];
   }
   set Components(c) {
     const this$ = this;
-    this$["components@1163"] = c;
+    this$["components@1169"] = c;
   }
   get Datamap() {
     const this$ = this;
-    return unwrap(this$["datamap@1164"]);
+    return unwrap(this$["datamap@1170"]);
   }
   set Datamap(dm) {
     const this$ = this;
-    this$["datamap@1164"] = dm;
+    this$["datamap@1170"] = dm;
   }
   get Contacts() {
     const this$ = this;
-    return this$["contacts@1165"];
+    return this$["contacts@1171"];
   }
   set Contacts(c) {
     const this$ = this;
-    this$["contacts@1165"] = c;
+    this$["contacts@1171"] = c;
   }
   get CWLDescription() {
     const this$ = this;
-    return unwrap(this$["cwlDescription@1166"]);
+    return unwrap(this$["cwlDescription@1172"]);
   }
   set CWLDescription(c) {
     const this$ = this;
-    this$["cwlDescription@1166"] = c;
+    this$["cwlDescription@1172"] = c;
   }
   get Comments() {
     const this$ = this;
-    return this$["comments@1167"];
+    return this$["comments@1173"];
   }
   set Comments(c) {
     const this$ = this;
-    this$["comments@1167"] = c;
+    this$["comments@1173"] = c;
   }
   get StaticHash() {
     const this$ = this;
@@ -1432,14 +1518,23 @@ class ArcWorkflow {
   static get FileName() {
     return "isa.run.xlsx";
   }
+  /**
+   * Returns the count of registered subWorkflow *identifiers*. This is not necessarily the same as the count of registered subWorkflows, as not all identifiers correspond to an existing subWorkflow.
+   */
   get SubWorkflowIdentifiersCount() {
     const this$ = this;
     return this$.SubWorkflowIdentifiers.length | 0;
   }
+  /**
+   * Returns the count of registered subWorkflows. This is not necessarily the same as the count of registered subWorkflow *identifiers*, as not all identifiers correspond to an existing subWorkflow.
+   */
   get SubWorkflowCount() {
     const this$ = this;
     return this$.SubWorkflows.length | 0;
   }
+  /**
+   * Returns all subWorkflows registered in this workflow, that correspond to an existing subWorkflow object in the associated investigation.
+   */
   get SubWorkflows() {
     const this$ = this;
     let inv;
@@ -1447,11 +1542,14 @@ class ArcWorkflow {
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     const collection = choose((workflowIdentifier) => inv.TryGetWorkflow(workflowIdentifier), this$.SubWorkflowIdentifiers);
     return Array.from(collection);
   }
+  /**
+   * Returns all registered subWorkflow identifiers that do not correspond to an existing subWorkflow object in the associated investigation.
+   */
   get VacantSubWorkflowIdentifiers() {
     const this$ = this;
     let inv;
@@ -1459,11 +1557,14 @@ class ArcWorkflow {
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     const collection = filter((arg) => !inv.ContainsWorkflow(arg), this$.SubWorkflowIdentifiers);
     return Array.from(collection);
   }
+  /**
+   * Add subWorkflow to investigation and register it to workflow.
+   */
   AddSubWorkflow(subWorkflow) {
     const this$ = this;
     let inv;
@@ -1471,7 +1572,7 @@ class ArcWorkflow {
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     inv.AddWorkflow(subWorkflow);
   }
@@ -1498,9 +1599,9 @@ class ArcWorkflow {
     const this$ = this;
     if (contains(subWorkflowIdentifier, this$.SubWorkflowIdentifiers, {
       Equals: (x, y) => x === y,
-      GetHashCode: stringHash
+      GetHashCode: (x) => stringHash(x) | 0
     })) {
-      throw new Error(`SubWorkflow \`${subWorkflowIdentifier}\` is already registered on the workflow.`);
+      throw new Exception(concat("SubWorkflow `", subWorkflowIdentifier, "` is already registered on the workflow."));
     }
     void this$.SubWorkflowIdentifiers.push(subWorkflowIdentifier);
   }
@@ -1515,7 +1616,7 @@ class ArcWorkflow {
     const this$ = this;
     removeInPlace(subWorkflowIdentifier, this$.SubWorkflowIdentifiers, {
       Equals: (x, y) => x === y,
-      GetHashCode: stringHash
+      GetHashCode: (x) => stringHash(x) | 0
     });
   }
   static deregisterSubWorkflow(subWorkflowIdentifier) {
@@ -1529,16 +1630,16 @@ class ArcWorkflow {
     const this$ = this;
     if (!contains(subWorkflowIdentifier, this$.SubWorkflowIdentifiers, {
       Equals: (x, y) => x === y,
-      GetHashCode: stringHash
+      GetHashCode: (x) => stringHash(x) | 0
     })) {
-      throw new Error(`SubWorkflow \`${subWorkflowIdentifier}\` is not registered on the workflow.`);
+      throw new Exception(concat("SubWorkflow `", subWorkflowIdentifier, "` is not registered on the workflow."));
     }
     let inv;
     const investigation = this$.Investigation;
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     return inv.GetWorkflow(subWorkflowIdentifier);
   }
@@ -1554,6 +1655,9 @@ class ArcWorkflow {
       return copy.SubWorkflows;
     };
   }
+  /**
+   * Returns ArcSubWorkflows registered in workflow, or if no parent exists, initializies new ArcSubWorkflow from identifier.
+   */
   GetRegisteredSubWorkflowsOrIdentifier() {
     const this$ = this;
     const matchValue = this$.Investigation;
@@ -1571,20 +1675,35 @@ class ArcWorkflow {
       }, this$.SubWorkflowIdentifiers);
     }
   }
+  /**
+   * Returns ArcSubWorkflows registered in workflow, or if no parent exists, initializies new ArcSubWorkflow from identifier.
+   */
   static getRegisteredSubWorkflowsOrIdentifier() {
     return (workflow) => {
       const copy = workflow.Copy();
       return copy.GetRegisteredSubWorkflowsOrIdentifier();
     };
   }
+  /**
+   * Copies ArcStudy object without the pointer to the parent ArcInvestigation
+   * 
+   * This copy does only contain the identifiers of the registered ArcAssays and not the actual objects.
+   * 
+   * In order to copy the ArcAssays as well, use the Copy() method of the ArcInvestigation.
+   */
   Copy(copyInvestigationRef) {
+    let w = void 0, d = void 0;
     const this$ = this;
     const copyInvestigationRef_1 = defaultArg(copyInvestigationRef, false);
-    const nextWorkFlowType = map((w) => w.Copy(), this$.WorkflowType);
+    let nextWorkFlowType;
+    const option_1 = this$.WorkflowType;
+    nextWorkFlowType = option_1 != null ? (w = value(option_1), w.Copy()) : void 0;
     const nextSubWorkflowIdentifiers = Array.from(this$.SubWorkflowIdentifiers);
     const nextParameters = ResizeArray_map((x) => x, this$.Parameters);
     const nextComponents = ResizeArray_map((x_1) => x_1, this$.Components);
-    const nextDatamap = map((d) => d.Copy(), this$.Datamap);
+    let nextDatamap;
+    const option_3 = this$.Datamap;
+    nextDatamap = option_3 != null ? (d = value(option_3), d.Copy()) : void 0;
     const nextContacts = ResizeArray_map((c) => c.Copy(), this$.Contacts);
     const nextComments = ResizeArray_map((c_1) => c_1.Copy(), this$.Comments);
     let workflow;
@@ -1601,7 +1720,7 @@ class ArcWorkflow {
     return workflow;
   }
   StructurallyEquals(other) {
-    let a, b, a_1, b_1, a_2, b_2, a_3, b_3, a_4, b_4;
+    let a = void 0, b = void 0, a_1 = void 0, b_1 = void 0, a_2 = void 0, b_2 = void 0, a_3 = void 0, b_3 = void 0, a_4 = void 0, b_4 = void 0;
     const this$ = this;
     return forAll((x) => x === true, [this$.Identifier === other.Identifier, equals(this$.Title, other.Title), equals(this$.Description, other.Description), equals(this$.WorkflowType, other.WorkflowType), equals(this$.URI, other.URI), equals(this$.Version, other.Version), (a = this$.SubWorkflowIdentifiers, b = other.SubWorkflowIdentifiers, length(a) === length(b) && fold((acc, e) => {
       if (acc) {
@@ -1609,32 +1728,37 @@ class ArcWorkflow {
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_1) => item(i_1, a) === item(i_1, b), rangeDouble(0, 1, length(a) - 1)))))), (a_1 = this$.Parameters, b_1 = other.Parameters, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
+    }, true, toList(delay(() => map((i_1) => item(i_1, a) === item(i_1, b), rangeDouble(0, 1, length(a) - 1)))))), (a_1 = this$.Parameters, b_1 = other.Parameters, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
       if (acc_1) {
         return e_1;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.Components, b_2 = other.Components, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
+    }, true, toList(delay(() => map((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.Components, b_2 = other.Components, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
       if (acc_2) {
         return e_2;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1)))))), equals(this$.Datamap, other.Datamap), (a_3 = this$.Contacts, b_3 = other.Contacts, length(a_3) === length(b_3) && fold((acc_3, e_3) => {
+    }, true, toList(delay(() => map((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1)))))), equals(this$.Datamap, other.Datamap), (a_3 = this$.Contacts, b_3 = other.Contacts, length(a_3) === length(b_3) && fold((acc_3, e_3) => {
       if (acc_3) {
         return e_3;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_4) => equals(item(i_4, a_3), item(i_4, b_3)), rangeDouble(0, 1, length(a_3) - 1)))))), equals(this$.CWLDescription, other.CWLDescription), (a_4 = this$.Comments, b_4 = other.Comments, length(a_4) === length(b_4) && fold((acc_4, e_4) => {
+    }, true, toList(delay(() => map((i_4) => equals(item(i_4, a_3), item(i_4, b_3)), rangeDouble(0, 1, length(a_3) - 1)))))), equals(this$.CWLDescription, other.CWLDescription), (a_4 = this$.Comments, b_4 = other.Comments, length(a_4) === length(b_4) && fold((acc_4, e_4) => {
       if (acc_4) {
         return e_4;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_5) => equals(item(i_5, a_4), item(i_5, b_4)), rangeDouble(0, 1, length(a_4) - 1))))))]);
+    }, true, toList(delay(() => map((i_5) => equals(item(i_5, a_4), item(i_5, b_4)), rangeDouble(0, 1, length(a_4) - 1))))))]);
   }
+  /**
+   * Use this function to check if this ArcWorkflow and the input ArcWorkflow refer to the same object.
+   * 
+   * If true, updating one will update the other due to mutability.
+   */
   ReferenceEquals(other) {
     const this$ = this;
     return this$ === other;
@@ -1656,7 +1780,7 @@ class ArcWorkflow {
     return toText(printf("ArcWorkflow {\r\n    Identifier = %A,\r\n    Title = %A,\r\n    Description = %A,\r\n    WorkflowType = %A,\r\n    URI = %A,\r\n    Version = %A,\r\n    SubWorkflowIdentifiers = %A,\r\n    Parameters = %A,\r\n    Components = %A,\r\n    Datamap = %A,\r\n    Contacts = %A,\r\n    Comments = %A}"))(arg)(arg_1)(arg_2)(arg_3)(arg_4)(arg_5)(arg_6)(arg_7)(arg_8)(arg_9)(arg_10)(arg_11);
   }
   Equals(other) {
-    let s;
+    let s = void 0;
     const this$ = this;
     return other instanceof ArcWorkflow && (s = other, this$.StructurallyEquals(s));
   }
@@ -1678,33 +1802,39 @@ function ArcWorkflow_$ctor_Z5FF2D3D5(identifier, title, description, workflowTyp
 class ArcRun extends ArcTables {
   constructor(identifier, title, description, measurementType, technologyType, technologyPlatform, workflowIdentifiers, tables, datamap, performers, cwlDescription, cwlInput, comments) {
     super(defaultArg(tables, []));
-    let identifier_1;
+    let identifier_1 = void 0;
     const performers_1 = defaultArg(performers, []);
     const comments_1 = defaultArg(comments, []);
     const workflowIdentifiers_1 = defaultArg(workflowIdentifiers, []);
     const cwlInput_1 = defaultArg(cwlInput, []);
-    this["identifier@1453"] = (identifier_1 = identifier.trim(), checkValidCharacters(identifier_1), identifier_1);
-    this["title@1457"] = title;
-    this["description@1458"] = description;
+    this["identifier@1462"] = (identifier_1 = identifier.trim(), checkValidCharacters(identifier_1), identifier_1);
+    this["title@1466"] = title;
+    this["description@1467"] = description;
     this.investigation = void 0;
-    this["measurementType@1460"] = measurementType;
-    this["technologyType@1461"] = technologyType;
-    this["technologyPlatform@1462"] = technologyPlatform;
-    this["workflowIdentifiers@1463-1"] = workflowIdentifiers_1;
-    this["datamap@1464"] = datamap;
-    this["performers@1465-1"] = performers_1;
-    this["cwlDescription@1466"] = cwlDescription;
-    this["cwlInput@1467-1"] = cwlInput_1;
-    this["comments@1468-1"] = comments_1;
+    this["measurementType@1469"] = measurementType;
+    this["technologyType@1470"] = technologyType;
+    this["technologyPlatform@1471"] = technologyPlatform;
+    this["workflowIdentifiers@1472-1"] = workflowIdentifiers_1;
+    this["datamap@1473"] = datamap;
+    this["performers@1474-1"] = performers_1;
+    this["cwlDescription@1475"] = cwlDescription;
+    this["cwlInput@1476-1"] = cwlInput_1;
+    this["comments@1477-1"] = comments_1;
     this.staticHash = 0;
   }
+  /**
+   * Must be unique in one study
+   */
   get Identifier() {
     const this$ = this;
-    return this$["identifier@1453"];
+    return this$["identifier@1462"];
   }
+  /**
+   * Must be unique in one study
+   */
   set Identifier(i) {
     const this$ = this;
-    this$["identifier@1453"] = i;
+    this$["identifier@1462"] = i;
   }
   get Investigation() {
     const this$ = this;
@@ -1716,91 +1846,91 @@ class ArcRun extends ArcTables {
   }
   get Title() {
     const this$ = this;
-    return unwrap(this$["title@1457"]);
+    return unwrap(this$["title@1466"]);
   }
   set Title(t) {
     const this$ = this;
-    this$["title@1457"] = t;
+    this$["title@1466"] = t;
   }
   get Description() {
     const this$ = this;
-    return unwrap(this$["description@1458"]);
+    return unwrap(this$["description@1467"]);
   }
   set Description(d) {
     const this$ = this;
-    this$["description@1458"] = d;
+    this$["description@1467"] = d;
   }
   get MeasurementType() {
     const this$ = this;
-    return unwrap(this$["measurementType@1460"]);
+    return unwrap(this$["measurementType@1469"]);
   }
   set MeasurementType(n) {
     const this$ = this;
-    this$["measurementType@1460"] = n;
+    this$["measurementType@1469"] = n;
   }
   get TechnologyType() {
     const this$ = this;
-    return unwrap(this$["technologyType@1461"]);
+    return unwrap(this$["technologyType@1470"]);
   }
   set TechnologyType(n) {
     const this$ = this;
-    this$["technologyType@1461"] = n;
+    this$["technologyType@1470"] = n;
   }
   get TechnologyPlatform() {
     const this$ = this;
-    return unwrap(this$["technologyPlatform@1462"]);
+    return unwrap(this$["technologyPlatform@1471"]);
   }
   set TechnologyPlatform(n) {
     const this$ = this;
-    this$["technologyPlatform@1462"] = n;
+    this$["technologyPlatform@1471"] = n;
   }
   get WorkflowIdentifiers() {
     const this$ = this;
-    return this$["workflowIdentifiers@1463-1"];
+    return this$["workflowIdentifiers@1472-1"];
   }
   set WorkflowIdentifiers(w) {
     const this$ = this;
-    this$["workflowIdentifiers@1463-1"] = w;
+    this$["workflowIdentifiers@1472-1"] = w;
   }
   get Datamap() {
     const this$ = this;
-    return unwrap(this$["datamap@1464"]);
+    return unwrap(this$["datamap@1473"]);
   }
   set Datamap(n) {
     const this$ = this;
-    this$["datamap@1464"] = n;
+    this$["datamap@1473"] = n;
   }
   get Performers() {
     const this$ = this;
-    return this$["performers@1465-1"];
+    return this$["performers@1474-1"];
   }
   set Performers(n) {
     const this$ = this;
-    this$["performers@1465-1"] = n;
+    this$["performers@1474-1"] = n;
   }
   get CWLDescription() {
     const this$ = this;
-    return unwrap(this$["cwlDescription@1466"]);
+    return unwrap(this$["cwlDescription@1475"]);
   }
   set CWLDescription(n) {
     const this$ = this;
-    this$["cwlDescription@1466"] = n;
+    this$["cwlDescription@1475"] = n;
   }
   get CWLInput() {
     const this$ = this;
-    return this$["cwlInput@1467-1"];
+    return this$["cwlInput@1476-1"];
   }
   set CWLInput(n) {
     const this$ = this;
-    this$["cwlInput@1467-1"] = n;
+    this$["cwlInput@1476-1"] = n;
   }
   get Comments() {
     const this$ = this;
-    return this$["comments@1468-1"];
+    return this$["comments@1477-1"];
   }
   set Comments(n) {
     const this$ = this;
-    this$["comments@1468-1"] = n;
+    this$["comments@1477-1"] = n;
   }
   get StaticHash() {
     const this$ = this;
@@ -1822,6 +1952,9 @@ class ArcRun extends ArcTables {
   static get FileName() {
     return "isa.run.xlsx";
   }
+  /**
+   * Returns the count of workflow *identifiers*. This is not necessarily the same as the count of workflows, as not all identifiers correspond to an existing workflow.
+   */
   get WorkflowIdentifierCount() {
     const this$ = this;
     return this$.WorkflowIdentifiers.length | 0;
@@ -1830,6 +1963,9 @@ class ArcRun extends ArcTables {
     const this$ = this;
     return this$.Workflows.length | 0;
   }
+  /**
+   * Returns all workflows registered in this run, that correspond to an existing workflow object in the associated investigation.
+   */
   get Workflows() {
     const this$ = this;
     let inv;
@@ -1837,11 +1973,14 @@ class ArcRun extends ArcTables {
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     const collection = choose((workflowIdentifier) => inv.TryGetWorkflow(workflowIdentifier), this$.WorkflowIdentifiers);
     return Array.from(collection);
   }
+  /**
+   * Returns all registered workflow identifiers that do not correspond to an existing workflow object in the associated investigation.
+   */
   get VacantWorkflowIdentifiers() {
     const this$ = this;
     let inv;
@@ -1849,7 +1988,7 @@ class ArcRun extends ArcTables {
     if (investigation != null) {
       inv = value(investigation);
     } else {
-      throw new Error("Cannot execute this function. Object is not part of ArcInvestigation.");
+      throw new Exception("Cannot execute this function. Object is not part of ArcInvestigation.");
     }
     const collection = filter((arg) => !inv.ContainsWorkflow(arg), this$.WorkflowIdentifiers);
     return Array.from(collection);
@@ -1881,12 +2020,18 @@ class ArcRun extends ArcTables {
       return c;
     };
   }
+  /**
+   * Receive **copy** of table at `index`
+   */
   static getTableAt(index) {
     return (run) => {
       const newRun = run.Copy();
       return newRun.GetTableAt(index);
     };
   }
+  /**
+   * Receive **copy** of table with `name` = `ArcTable.Name`
+   */
   static getTable(name) {
     return (run) => {
       const newRun = run.Copy();
@@ -2076,10 +2221,13 @@ class ArcRun extends ArcTables {
     return run;
   }
   Copy() {
+    let d = void 0;
     const this$ = this;
     const nextTables = ResizeArray_map((c) => c.Copy(), this$.Tables);
     const nextComments = ResizeArray_map((c_1) => c_1.Copy(), this$.Comments);
-    const nextDatamap = map((d) => d.Copy(), this$.Datamap);
+    let nextDatamap;
+    const option_1 = this$.Datamap;
+    nextDatamap = option_1 != null ? (d = value(option_1), d.Copy()) : void 0;
     const nextPerformers = ResizeArray_map((c_2) => c_2.Copy(), this$.Performers);
     const nextWorkflowIdentifiers = ResizeArray_map((c_3) => c_3, this$.WorkflowIdentifiers);
     const identifier = this$.Identifier;
@@ -2092,6 +2240,9 @@ class ArcRun extends ArcTables {
     const cwlInput = this$.CWLInput;
     return ArcRun.make(identifier, title, description, measurementType, technologyType, technologyPlatform, nextWorkflowIdentifiers, nextTables, nextDatamap, nextPerformers, cwlDescription, cwlInput, nextComments);
   }
+  /**
+   * Updates given run with another run, Identifier will never be updated. By default update is full replace. Optional Parameters can be used to specify update logic.
+   */
   UpdateBy(run, onlyReplaceExisting, appendSequences) {
     const this$ = this;
     const onlyReplaceExisting_1 = defaultArg(onlyReplaceExisting, false);
@@ -2126,7 +2277,7 @@ class ArcRun extends ArcTables {
             const e = enumerator["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e, combined, {
               Equals: (x_1, y) => x_1 === y,
-              GetHashCode: stringHash
+              GetHashCode: (x_1) => stringHash(x_1) | 0
             })) {
               void combined.push(e);
             }
@@ -2140,7 +2291,7 @@ class ArcRun extends ArcTables {
             const e_1 = enumerator_1["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_1, combined, {
               Equals: (x_2, y_1) => x_2 === y_1,
-              GetHashCode: stringHash
+              GetHashCode: (x_2) => stringHash(x_2) | 0
             })) {
               void combined.push(e_1);
             }
@@ -2169,7 +2320,7 @@ class ArcRun extends ArcTables {
             const e_2 = enumerator_2["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_2, combined_1, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_4) => safeHash(x_4) | 0
             })) {
               void combined_1.push(e_2);
             }
@@ -2183,7 +2334,7 @@ class ArcRun extends ArcTables {
             const e_1_1 = enumerator_1_1["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_1_1, combined_1, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_5) => safeHash(x_5) | 0
             })) {
               void combined_1.push(e_1_1);
             }
@@ -2209,7 +2360,7 @@ class ArcRun extends ArcTables {
             const e_3 = enumerator_3["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_3, combined_2, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_7) => safeHash(x_7) | 0
             })) {
               void combined_2.push(e_3);
             }
@@ -2223,7 +2374,7 @@ class ArcRun extends ArcTables {
             const e_1_2 = enumerator_1_2["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_1_2, combined_2, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_8) => safeHash(x_8) | 0
             })) {
               void combined_2.push(e_1_2);
             }
@@ -2252,7 +2403,7 @@ class ArcRun extends ArcTables {
             const e_4 = enumerator_4["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_4, combined_3, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_10) => safeHash(x_10) | 0
             })) {
               void combined_3.push(e_4);
             }
@@ -2266,7 +2417,7 @@ class ArcRun extends ArcTables {
             const e_1_3 = enumerator_1_3["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_1_3, combined_3, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_11) => safeHash(x_11) | 0
             })) {
               void combined_3.push(e_1_3);
             }
@@ -2292,7 +2443,7 @@ class ArcRun extends ArcTables {
             const e_5 = enumerator_5["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_5, combined_4, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_13) => safeHash(x_13) | 0
             })) {
               void combined_4.push(e_5);
             }
@@ -2306,7 +2457,7 @@ class ArcRun extends ArcTables {
             const e_1_4 = enumerator_1_4["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains$1(e_1_4, combined_4, {
               Equals: equals,
-              GetHashCode: safeHash
+              GetHashCode: (x_14) => safeHash(x_14) | 0
             })) {
               void combined_4.push(e_1_4);
             }
@@ -2343,7 +2494,7 @@ class ArcRun extends ArcTables {
     this$.Investigation = void 0;
   }
   StructurallyEquals(other) {
-    let a, b, a_1, b_1, a_2, b_2, a_3, b_3, a_4, b_4;
+    let a = void 0, b = void 0, a_1 = void 0, b_1 = void 0, a_2 = void 0, b_2 = void 0, a_3 = void 0, b_3 = void 0, a_4 = void 0, b_4 = void 0;
     const this$ = this;
     return forAll((x) => x === true, [this$.Identifier === other.Identifier, equals(this$.Title, other.Title), equals(this$.Description, other.Description), equals(this$.MeasurementType, other.MeasurementType), equals(this$.TechnologyType, other.TechnologyType), equals(this$.TechnologyPlatform, other.TechnologyPlatform), (a = this$.WorkflowIdentifiers, b = other.WorkflowIdentifiers, length(a) === length(b) && fold((acc, e) => {
       if (acc) {
@@ -2351,38 +2502,43 @@ class ArcRun extends ArcTables {
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_1) => item(i_1, a) === item(i_1, b), rangeDouble(0, 1, length(a) - 1)))))), equals(this$.Datamap, other.Datamap), (a_1 = this$.Tables, b_1 = other.Tables, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
+    }, true, toList(delay(() => map((i_1) => item(i_1, a) === item(i_1, b), rangeDouble(0, 1, length(a) - 1)))))), equals(this$.Datamap, other.Datamap), (a_1 = this$.Tables, b_1 = other.Tables, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
       if (acc_1) {
         return e_1;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.Performers, b_2 = other.Performers, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
+    }, true, toList(delay(() => map((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.Performers, b_2 = other.Performers, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
       if (acc_2) {
         return e_2;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1)))))), equals(this$.CWLDescription, other.CWLDescription), (a_3 = this$.CWLInput, b_3 = other.CWLInput, length(a_3) === length(b_3) && fold((acc_3, e_3) => {
+    }, true, toList(delay(() => map((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1)))))), equals(this$.CWLDescription, other.CWLDescription), (a_3 = this$.CWLInput, b_3 = other.CWLInput, length(a_3) === length(b_3) && fold((acc_3, e_3) => {
       if (acc_3) {
         return e_3;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_4) => equals(item(i_4, a_3), item(i_4, b_3)), rangeDouble(0, 1, length(a_3) - 1)))))), (a_4 = this$.Comments, b_4 = other.Comments, length(a_4) === length(b_4) && fold((acc_4, e_4) => {
+    }, true, toList(delay(() => map((i_4) => equals(item(i_4, a_3), item(i_4, b_3)), rangeDouble(0, 1, length(a_3) - 1)))))), (a_4 = this$.Comments, b_4 = other.Comments, length(a_4) === length(b_4) && fold((acc_4, e_4) => {
       if (acc_4) {
         return e_4;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_5) => equals(item(i_5, a_4), item(i_5, b_4)), rangeDouble(0, 1, length(a_4) - 1))))))]);
+    }, true, toList(delay(() => map((i_5) => equals(item(i_5, a_4), item(i_5, b_4)), rangeDouble(0, 1, length(a_4) - 1))))))]);
   }
+  /**
+   * Use this function to check if this ArcRun and the input ArcRun refer to the same object.
+   * 
+   * If true, updating one will update the other due to mutability.
+   */
   ReferenceEquals(other) {
     const this$ = this;
     return this$ === other;
   }
   Equals(other) {
-    let run;
+    let run = void 0;
     const this$ = this;
     return other instanceof ArcRun && (run = other, this$.StructurallyEquals(run));
   }
@@ -2459,143 +2615,149 @@ class ArcInvestigation {
     const registeredStudyIdentifiers_1 = defaultArg(registeredStudyIdentifiers, []);
     const comments_1 = defaultArg(comments, []);
     const remarks_1 = defaultArg(remarks, []);
-    this["identifier@1951"] = identifier;
-    this["title@1952"] = title;
-    this["description@1953"] = description;
-    this["submissionDate@1954"] = submissionDate;
-    this["publicReleaseDate@1955"] = publicReleaseDate;
-    this["ontologySourceReferences@1956-1"] = ontologySourceReferences_1;
-    this["publications@1957-1"] = publications_1;
-    this["contacts@1958-1"] = contacts_1;
-    this["assays@1959-1"] = assays_1;
-    this["studies@1960-1"] = studies_1;
-    this["workflows@1961-1"] = workflows_1;
-    this["runs@1962-1"] = runs_1;
-    this["registeredStudyIdentifiers@1963-1"] = registeredStudyIdentifiers_1;
-    this["comments@1964-1"] = comments_1;
-    this["remarks@1965-1"] = remarks_1;
+    this["identifier@1963"] = identifier;
+    this["title@1964"] = title;
+    this["description@1965"] = description;
+    this["submissionDate@1966"] = submissionDate;
+    this["publicReleaseDate@1967"] = publicReleaseDate;
+    this["ontologySourceReferences@1968-1"] = ontologySourceReferences_1;
+    this["publications@1969-1"] = publications_1;
+    this["contacts@1970-1"] = contacts_1;
+    this["assays@1971-1"] = assays_1;
+    this["studies@1972-1"] = studies_1;
+    this["workflows@1973-1"] = workflows_1;
+    this["runs@1974-1"] = runs_1;
+    this["registeredStudyIdentifiers@1975-1"] = registeredStudyIdentifiers_1;
+    this["comments@1976-1"] = comments_1;
+    this["remarks@1977-1"] = remarks_1;
     this.staticHash = 0;
-    this["init@1922"] = 1;
+    this["init@1934"] = 1;
   }
+  /**
+   * Must be unique in one investigation
+   */
   get Identifier() {
     const this$ = this;
-    return this$["identifier@1951"];
+    return this$["identifier@1963"];
   }
+  /**
+   * Must be unique in one investigation
+   */
   set Identifier(i) {
     const this$ = this;
-    this$["identifier@1951"] = i;
+    this$["identifier@1963"] = i;
   }
   get Title() {
     const this$ = this;
-    return unwrap(this$["title@1952"]);
+    return unwrap(this$["title@1964"]);
   }
   set Title(n) {
     const this$ = this;
-    this$["title@1952"] = n;
+    this$["title@1964"] = n;
   }
   get Description() {
     const this$ = this;
-    return unwrap(this$["description@1953"]);
+    return unwrap(this$["description@1965"]);
   }
   set Description(n) {
     const this$ = this;
-    this$["description@1953"] = n;
+    this$["description@1965"] = n;
   }
   get SubmissionDate() {
     const this$ = this;
-    return unwrap(this$["submissionDate@1954"]);
+    return unwrap(this$["submissionDate@1966"]);
   }
   set SubmissionDate(n) {
     const this$ = this;
-    this$["submissionDate@1954"] = n;
+    this$["submissionDate@1966"] = n;
   }
   get PublicReleaseDate() {
     const this$ = this;
-    return unwrap(this$["publicReleaseDate@1955"]);
+    return unwrap(this$["publicReleaseDate@1967"]);
   }
   set PublicReleaseDate(n) {
     const this$ = this;
-    this$["publicReleaseDate@1955"] = n;
+    this$["publicReleaseDate@1967"] = n;
   }
   get OntologySourceReferences() {
     const this$ = this;
-    return this$["ontologySourceReferences@1956-1"];
+    return this$["ontologySourceReferences@1968-1"];
   }
   set OntologySourceReferences(n) {
     const this$ = this;
-    this$["ontologySourceReferences@1956-1"] = n;
+    this$["ontologySourceReferences@1968-1"] = n;
   }
   get Publications() {
     const this$ = this;
-    return this$["publications@1957-1"];
+    return this$["publications@1969-1"];
   }
   set Publications(n) {
     const this$ = this;
-    this$["publications@1957-1"] = n;
+    this$["publications@1969-1"] = n;
   }
   get Contacts() {
     const this$ = this;
-    return this$["contacts@1958-1"];
+    return this$["contacts@1970-1"];
   }
   set Contacts(n) {
     const this$ = this;
-    this$["contacts@1958-1"] = n;
+    this$["contacts@1970-1"] = n;
   }
   get Assays() {
     const this$ = this;
-    return this$["assays@1959-1"];
+    return this$["assays@1971-1"];
   }
   set Assays(n) {
     const this$ = this;
-    this$["assays@1959-1"] = n;
+    this$["assays@1971-1"] = n;
   }
   get Studies() {
     const this$ = this;
-    return this$["studies@1960-1"];
+    return this$["studies@1972-1"];
   }
   set Studies(n) {
     const this$ = this;
-    this$["studies@1960-1"] = n;
+    this$["studies@1972-1"] = n;
   }
   get Workflows() {
     const this$ = this;
-    return this$["workflows@1961-1"];
+    return this$["workflows@1973-1"];
   }
   set Workflows(n) {
     const this$ = this;
-    this$["workflows@1961-1"] = n;
+    this$["workflows@1973-1"] = n;
   }
   get Runs() {
     const this$ = this;
-    return this$["runs@1962-1"];
+    return this$["runs@1974-1"];
   }
   set Runs(n) {
     const this$ = this;
-    this$["runs@1962-1"] = n;
+    this$["runs@1974-1"] = n;
   }
   get RegisteredStudyIdentifiers() {
     const this$ = this;
-    return this$["registeredStudyIdentifiers@1963-1"];
+    return this$["registeredStudyIdentifiers@1975-1"];
   }
   set RegisteredStudyIdentifiers(n) {
     const this$ = this;
-    this$["registeredStudyIdentifiers@1963-1"] = n;
+    this$["registeredStudyIdentifiers@1975-1"] = n;
   }
   get Comments() {
     const this$ = this;
-    return this$["comments@1964-1"];
+    return this$["comments@1976-1"];
   }
   set Comments(n) {
     const this$ = this;
-    this$["comments@1964-1"] = n;
+    this$["comments@1976-1"] = n;
   }
   get Remarks() {
     const this$ = this;
-    return this$["remarks@1965-1"];
+    return this$["remarks@1977-1"];
   }
   set Remarks(n) {
     const this$ = this;
-    this$["remarks@1965-1"] = n;
+    this$["remarks@1977-1"] = n;
   }
   get StaticHash() {
     const this$ = this;
@@ -2623,7 +2785,7 @@ class ArcInvestigation {
   }
   get AssayIdentifiers() {
     const this$ = this;
-    return Array.from(map$1((x) => x.Identifier, this$.Assays));
+    return Array.from(map((x) => x.Identifier, this$.Assays));
   }
   get UnregisteredAssays() {
     const this$ = this;
@@ -2632,10 +2794,10 @@ class ArcInvestigation {
   AddAssay(assay, registerIn) {
     const this$ = this;
     const assayIdent = assay.Identifier;
-    const matchValue = tryFindIndex((x_1) => x_1 === assayIdent, map$1((x) => x.Identifier, this$.Assays));
+    const matchValue = tryFindIndex((x_1) => x_1 === assayIdent, map((x) => x.Identifier, this$.Assays));
     if (matchValue == null) {
     } else {
-      throw new Error(`Cannot create assay with name ${assayIdent}, as assay names must be unique and assay at index ${value(matchValue)} has the same name.`);
+      throw new Exception(`Cannot create assay with name ${assayIdent}, as assay names must be unique and assay at index ${value(matchValue)} has the same name.`);
     }
     assay.Investigation = this$;
     void this$.Assays.push(assay);
@@ -2670,10 +2832,16 @@ class ArcInvestigation {
       return newInvestigation.InitAssay(assayIdentifier, unwrap(registerIn));
     };
   }
+  /**
+   * Removes assay at specified index from ArcInvestigation without deregistering it from studies.
+   */
   DeleteAssayAt(index) {
     const this$ = this;
     this$.Assays.splice(index, 1);
   }
+  /**
+   * Removes assay at specified index from ArcInvestigation without deregistering it from studies.
+   */
   static deleteAssayAt(index) {
     return (inv) => {
       const newInvestigation = inv.Copy();
@@ -2681,11 +2849,17 @@ class ArcInvestigation {
       return newInvestigation;
     };
   }
+  /**
+   * Removes assay with given identifier from ArcInvestigation without deregistering it from studies.
+   */
   DeleteAssay(assayIdentifier) {
     const this$ = this;
     const index = this$.GetAssayIndex(assayIdentifier) | 0;
     this$.DeleteAssayAt(index);
   }
+  /**
+   * Removes assay with given identifier from ArcInvestigation without deregistering it from studies.
+   */
   static deleteAssay(assayIdentifier) {
     return (inv) => {
       const newInv = inv.Copy();
@@ -2693,6 +2867,9 @@ class ArcInvestigation {
       return newInv;
     };
   }
+  /**
+   * Removes assay at specified index from ArcInvestigation and deregisteres it from all studies.
+   */
   RemoveAssayAt(index) {
     const this$ = this;
     const ident = this$.GetAssayAt(index).Identifier;
@@ -2707,6 +2884,9 @@ class ArcInvestigation {
       disposeSafe(enumerator);
     }
   }
+  /**
+   * Removes assay at specified index from ArcInvestigation and deregisteres it from all studies.
+   */
   static removeAssayAt(index) {
     return (inv) => {
       const newInvestigation = inv.Copy();
@@ -2714,11 +2894,17 @@ class ArcInvestigation {
       return newInvestigation;
     };
   }
+  /**
+   * Removes assay with specified identifier from ArcInvestigation and deregisteres it from all studies.
+   */
   RemoveAssay(assayIdentifier) {
     const this$ = this;
     const index = this$.GetAssayIndex(assayIdentifier) | 0;
     this$.RemoveAssayAt(index);
   }
+  /**
+   * Removes assay with specified identifier from ArcInvestigation and deregisteres it from all studies.
+   */
   static removeAssay(assayIdentifier) {
     return (inv) => {
       const newInv = inv.Copy();
@@ -2726,6 +2912,9 @@ class ArcInvestigation {
       return newInv;
     };
   }
+  /**
+   * Renames an assay in the whole investigation
+   */
   RenameAssay(oldIdentifier, newIdentifier) {
     const this$ = this;
     iterate((a) => {
@@ -2737,7 +2926,7 @@ class ArcInvestigation {
       const index = tryFindIndex((ai) => ai === oldIdentifier, s.RegisteredAssayIdentifiers);
       if (index != null) {
         const index_1 = value(index) | 0;
-        s.RegisteredAssayIdentifiers[index_1] = newIdentifier;
+        setItem(s.RegisteredAssayIdentifiers, index_1, newIdentifier);
       }
     }, this$.Studies);
   }
@@ -2748,6 +2937,9 @@ class ArcInvestigation {
       return newInv;
     };
   }
+  /**
+   * Renames an run in the whole investigation
+   */
   RenameRun(oldIdentifier, newIdentifier) {
     const this$ = this;
     iterate((a) => {
@@ -2763,6 +2955,9 @@ class ArcInvestigation {
       return newInv;
     };
   }
+  /**
+   * Renames an workflow in the whole investigation
+   */
   RenameWorkflow(oldIdentifier, newIdentifier) {
     const this$ = this;
     iterate((w) => {
@@ -2772,14 +2967,14 @@ class ArcInvestigation {
       const matchValue = tryFindIndex((subId) => subId === oldIdentifier, w.SubWorkflowIdentifiers);
       if (matchValue != null) {
         const i = value(matchValue) | 0;
-        w.SubWorkflowIdentifiers[i] = newIdentifier;
+        setItem(w.SubWorkflowIdentifiers, i, newIdentifier);
       }
     }, this$.Workflows);
     iterate((r) => {
       const matchValue_1 = tryFindIndex((wId) => wId === oldIdentifier, r.WorkflowIdentifiers);
       if (matchValue_1 != null) {
         const i_1 = value(matchValue_1) | 0;
-        r.WorkflowIdentifiers[i_1] = newIdentifier;
+        setItem(r.WorkflowIdentifiers, i_1, newIdentifier);
       }
     }, this$.Runs);
   }
@@ -2793,13 +2988,13 @@ class ArcInvestigation {
   SetAssayAt(index, assay) {
     const this$ = this;
     const assayIdent = assay.Identifier;
-    const matchValue = tryFindIndex((x) => x === assayIdent, map$1((a) => a.Identifier, removeAt(index, this$.Assays)));
+    const matchValue = tryFindIndex((x) => x === assayIdent, map((a) => a.Identifier, removeAt(index, this$.Assays)));
     if (matchValue == null) {
     } else {
-      throw new Error(`Cannot create assay with name ${assayIdent}, as assay names must be unique and assay at index ${value(matchValue)} has the same name.`);
+      throw new Exception(`Cannot create assay with name ${assayIdent}, as assay names must be unique and assay at index ${value(matchValue)} has the same name.`);
     }
     assay.Investigation = this$;
-    this$.Assays[index] = assay;
+    setItem(this$.Assays, index, assay);
     this$.DeregisterMissingAssays();
   }
   static setAssayAt(index, assay) {
@@ -2825,16 +3020,16 @@ class ArcInvestigation {
     const this$ = this;
     const index = this$.Assays.findIndex((a) => a.Identifier === assayIdentifier) | 0;
     if (index === -1) {
-      throw new Error(`Unable to find assay with specified identifier '${assayIdentifier}'!`);
+      throw new Exception(concat("Unable to find assay with specified identifier '", assayIdentifier, "'!"));
     }
     return index | 0;
   }
   static getAssayIndex(assayIdentifier) {
-    return (inv) => inv.GetAssayIndex(assayIdentifier);
+    return (inv) => inv.GetAssayIndex(assayIdentifier) | 0;
   }
   GetAssayAt(index) {
     const this$ = this;
-    return this$.Assays[index];
+    return item$1(index, this$.Assays);
   }
   static getAssayAt(index) {
     return (inv) => {
@@ -2846,7 +3041,7 @@ class ArcInvestigation {
     const this$ = this;
     const matchValue = this$.TryGetAssay(assayIdentifier);
     if (matchValue == null) {
-      throw new Error(ArcTypesAux_ErrorMsgs_unableToFindAssayIdentifier(assayIdentifier, this$.Identifier));
+      throw new Exception(ArcTypesAux_ErrorMsgs_unableToFindAssayIdentifier(assayIdentifier, this$.Identifier));
     } else {
       return value(matchValue);
     }
@@ -2874,18 +3069,30 @@ class ArcInvestigation {
   static containsAssay(assayIdentifier) {
     return (inv) => inv.ContainsAssay(assayIdentifier);
   }
+  /**
+   * Returns the count of registered study *identifiers*. This is not necessarily the same as the count of registered studies, as not all identifiers correspond to an existing study object.
+   */
   get RegisteredStudyIdentifierCount() {
     const this$ = this;
     return this$.RegisteredStudyIdentifiers.length | 0;
   }
+  /**
+   * Returns all studies registered in this investigation, that correspond to an existing study object investigation.
+   */
   get RegisteredStudies() {
     const this$ = this;
     return ResizeArray_choose((identifier) => this$.TryGetStudy(identifier), this$.RegisteredStudyIdentifiers);
   }
+  /**
+   * Returns the count of registered studies. This is not necessarily the same as the count of registered study *identifiers*, as not all identifiers correspond to an existing study object.
+   */
   get RegisteredStudyCount() {
     const this$ = this;
     return this$.RegisteredStudies.length | 0;
   }
+  /**
+   * Returns all registered study identifiers that do not correspond to an existing study object in the investigation.
+   */
   get VacantStudyIdentifiers() {
     const this$ = this;
     return ResizeArray_filter((arg) => !this$.ContainsStudy(arg), this$.RegisteredStudyIdentifiers);
@@ -2896,12 +3103,12 @@ class ArcInvestigation {
   }
   get StudyIdentifiers() {
     const this$ = this;
-    return toArray(map$1((x) => x.Identifier, this$.Studies));
+    return toArray(map((x) => x.Identifier, this$.Studies));
   }
   get UnregisteredStudies() {
     const this$ = this;
     return ResizeArray_filter((s) => {
-      let source, x;
+      let source = void 0, x = void 0;
       return !(source = this$.RegisteredStudyIdentifiers, exists((x = s.Identifier, (y) => x === y), source));
     }, this$.Studies);
   }
@@ -2911,7 +3118,7 @@ class ArcInvestigation {
     const matchValue = tryFindIndex((x) => x.Identifier === study_1.Identifier, this$.Studies);
     if (matchValue == null) {
     } else {
-      throw new Error(`Cannot create study with name ${study_1.Identifier}, as study names must be unique and study at index ${value(matchValue)} has the same name.`);
+      throw new Exception(`Cannot create study with name ${study_1.Identifier}, as study names must be unique and study at index ${value(matchValue)} has the same name.`);
     }
     study.Investigation = this$;
     void this$.Studies.push(study);
@@ -2941,14 +3148,14 @@ class ArcInvestigation {
     const matchValue = tryFind((x) => x === studyIdent, this$.StudyIdentifiers);
     if (matchValue != null) {
     } else {
-      throw new Error(`The given study with identifier '${studyIdent}' must be added to Investigation before it can be registered.`);
+      throw new Exception(concat("The given study with identifier '", studyIdent, "' must be added to Investigation before it can be registered."));
     }
     const studyIdent_1 = studyIdentifier;
     if (contains(studyIdent_1, this$.RegisteredStudyIdentifiers, {
       Equals: (x_1, y) => x_1 === y,
-      GetHashCode: stringHash
+      GetHashCode: (x_1) => stringHash(x_1) | 0
     })) {
-      throw new Error(`Study with identifier '${studyIdent_1}' is already registered!`);
+      throw new Exception(concat("Study with identifier '", studyIdent_1, "' is already registered!"));
     }
     void this$.RegisteredStudyIdentifiers.push(studyIdentifier);
   }
@@ -2972,10 +3179,16 @@ class ArcInvestigation {
       return copy;
     };
   }
+  /**
+   * Removes study at specified index from ArcInvestigation without deregistering it.
+   */
   DeleteStudyAt(index) {
     const this$ = this;
     this$.Studies.splice(index, 1);
   }
+  /**
+   * Removes study at specified index from ArcInvestigation without deregistering it.
+   */
   static deleteStudyAt(index) {
     return (i) => {
       const copy = i.Copy();
@@ -2983,11 +3196,17 @@ class ArcInvestigation {
       return copy;
     };
   }
+  /**
+   * Removes study with specified identifier from ArcInvestigation without deregistering it.
+   */
   DeleteStudy(studyIdentifier) {
     const this$ = this;
     const index = this$.Studies.findIndex((s) => s.Identifier === studyIdentifier) | 0;
     this$.DeleteStudyAt(index);
   }
+  /**
+   * Removes study with specified identifier from ArcInvestigation without deregistering it.
+   */
   static deleteStudy(studyIdentifier) {
     return (i) => {
       const copy = i.Copy();
@@ -2995,12 +3214,18 @@ class ArcInvestigation {
       return copy;
     };
   }
+  /**
+   * Removes study at specified index from ArcInvestigation and deregisteres it.
+   */
   RemoveStudyAt(index) {
     const this$ = this;
     const ident = this$.GetStudyAt(index).Identifier;
     this$.Studies.splice(index, 1);
     this$.DeregisterStudy(ident);
   }
+  /**
+   * Removes study at specified index from ArcInvestigation and deregisteres it.
+   */
   static removeStudyAt(index) {
     return (inv) => {
       const newInv = inv.Copy();
@@ -3008,11 +3233,17 @@ class ArcInvestigation {
       return newInv;
     };
   }
+  /**
+   * Removes study with specified identifier from ArcInvestigation and deregisteres it.
+   */
   RemoveStudy(studyIdentifier) {
     const this$ = this;
     const index = this$.GetStudyIndex(studyIdentifier) | 0;
     this$.RemoveStudyAt(index);
   }
+  /**
+   * Removes study with specified identifier from ArcInvestigation and deregisteres it.
+   */
   static removeStudy(studyIdentifier) {
     return (inv) => {
       const copy = inv.Copy();
@@ -3020,6 +3251,9 @@ class ArcInvestigation {
       return copy;
     };
   }
+  /**
+   * Renames a study in the whole investigation
+   */
   RenameStudy(oldIdentifier, newIdentifier) {
     const this$ = this;
     iterate((s) => {
@@ -3030,9 +3264,12 @@ class ArcInvestigation {
     const index = tryFindIndex((si) => si === oldIdentifier, this$.RegisteredStudyIdentifiers);
     if (index != null) {
       const index_1 = value(index) | 0;
-      this$.RegisteredStudyIdentifiers[index_1] = newIdentifier;
+      setItem(this$.RegisteredStudyIdentifiers, index_1, newIdentifier);
     }
   }
+  /**
+   * Renames a study in the whole investigation
+   */
   static renameStudy(oldIdentifier, newIdentifier) {
     return (inv) => {
       const newInv = inv.Copy();
@@ -3046,10 +3283,10 @@ class ArcInvestigation {
     const matchValue = tryFindIndex((x) => x.Identifier === study_1.Identifier, removeAt(index, this$.Studies));
     if (matchValue == null) {
     } else {
-      throw new Error(`Cannot create study with name ${study_1.Identifier}, as study names must be unique and study at index ${value(matchValue)} has the same name.`);
+      throw new Exception(`Cannot create study with name ${study_1.Identifier}, as study names must be unique and study at index ${value(matchValue)} has the same name.`);
     }
     study.Investigation = this$;
-    this$.Studies[index] = study;
+    setItem(this$.Studies, index, study);
   }
   static setStudyAt(index, study) {
     return (inv) => {
@@ -3074,16 +3311,16 @@ class ArcInvestigation {
     const this$ = this;
     const index = this$.Studies.findIndex((s) => s.Identifier === studyIdentifier) | 0;
     if (index === -1) {
-      throw new Error(`Unable to find study with specified identifier '${studyIdentifier}'!`);
+      throw new Exception(concat("Unable to find study with specified identifier '", studyIdentifier, "'!"));
     }
     return index | 0;
   }
   static getStudyIndex(studyIdentifier) {
-    return (inv) => inv.GetStudyIndex(studyIdentifier);
+    return (inv) => inv.GetStudyIndex(studyIdentifier) | 0;
   }
   GetStudyAt(index) {
     const this$ = this;
-    return this$.Studies[index];
+    return item$1(index, this$.Studies);
   }
   static getStudyAt(index) {
     return (inv) => {
@@ -3095,7 +3332,7 @@ class ArcInvestigation {
     const this$ = this;
     const matchValue = this$.TryGetStudy(studyIdentifier);
     if (matchValue == null) {
-      throw new Error(ArcTypesAux_ErrorMsgs_unableToFindStudyIdentifier(studyIdentifier, this$.Identifier));
+      throw new Exception(ArcTypesAux_ErrorMsgs_unableToFindStudyIdentifier(studyIdentifier, this$.Identifier));
     } else {
       return value(matchValue);
     }
@@ -3123,19 +3360,22 @@ class ArcInvestigation {
   static containsStudy(studyIdentifier) {
     return (inv) => inv.ContainsStudy(studyIdentifier);
   }
+  /**
+   * Register an existing assay from ArcInvestigation.Assays to a existing study.
+   */
   RegisterAssayAt(studyIndex, assayIdentifier) {
     const this$ = this;
     const study = this$.GetStudyAt(studyIndex);
-    const matchValue = tryFind((x) => x === assayIdentifier, map$1((a) => a.Identifier, this$.Assays));
+    const matchValue = tryFind((x) => x === assayIdentifier, map((a) => a.Identifier, this$.Assays));
     if (matchValue != null) {
     } else {
-      throw new Error("The given assay must be added to Investigation before it can be registered.");
+      throw new Exception("The given assay must be added to Investigation before it can be registered.");
     }
     const assayIdent_1 = assayIdentifier;
     const matchValue_1 = tryFindIndex((x_1) => x_1 === assayIdent_1, study.RegisteredAssayIdentifiers);
     if (matchValue_1 == null) {
     } else {
-      throw new Error(`Cannot create assay with name ${assayIdent_1}, as assay names must be unique and assay at index ${value(matchValue_1)} has the same name.`);
+      throw new Exception(`Cannot create assay with name ${assayIdent_1}, as assay names must be unique and assay at index ${value(matchValue_1)} has the same name.`);
     }
     study.RegisterAssay(assayIdentifier);
   }
@@ -3146,6 +3386,9 @@ class ArcInvestigation {
       return copy;
     };
   }
+  /**
+   * Register an existing assay from ArcInvestigation.Assays to a existing study.
+   */
   RegisterAssay(studyIdentifier, assayIdentifier) {
     const this$ = this;
     const index = this$.GetStudyIndex(studyIdentifier) | 0;
@@ -3186,7 +3429,7 @@ class ArcInvestigation {
     const this$ = this;
     removeInPlace(studyIdentifier, this$.RegisteredStudyIdentifiers, {
       Equals: (x, y) => x === y,
-      GetHashCode: stringHash
+      GetHashCode: (x) => stringHash(x) | 0
     });
   }
   static deregisterStudy(studyIdentifier) {
@@ -3202,18 +3445,18 @@ class ArcInvestigation {
   }
   get WorkflowIdentifiers() {
     const this$ = this;
-    return toArray(map$1((x) => x.Identifier, this$.Workflows));
+    return toArray(map((x) => x.Identifier, this$.Workflows));
   }
   GetWorkflowIndex(workflowIdentifier) {
     const this$ = this;
     const index = this$.Workflows.findIndex((w) => w.Identifier === workflowIdentifier) | 0;
     if (index === -1) {
-      throw new Error(`Unable to find workflow with specified identifier '${workflowIdentifier}'!`);
+      throw new Exception(concat("Unable to find workflow with specified identifier '", workflowIdentifier, "'!"));
     }
     return index | 0;
   }
   static getWorkflowIndex(workflowIdentifier) {
-    return (inv) => inv.GetWorkflowIndex(workflowIdentifier);
+    return (inv) => inv.GetWorkflowIndex(workflowIdentifier) | 0;
   }
   AddWorkflow(workflow) {
     const this$ = this;
@@ -3221,7 +3464,7 @@ class ArcInvestigation {
     const matchValue = tryFindIndex((x) => x.Identifier === workflow_1.Identifier, this$.Workflows);
     if (matchValue == null) {
     } else {
-      throw new Error(`Cannot create workflow with name ${workflow_1.Identifier}, as workflow names must be unique and workflow at index ${value(matchValue)} has the same name.`);
+      throw new Exception(`Cannot create workflow with name ${workflow_1.Identifier}, as workflow names must be unique and workflow at index ${value(matchValue)} has the same name.`);
     }
     workflow.Investigation = this$;
     void this$.Workflows.push(workflow);
@@ -3284,7 +3527,7 @@ class ArcInvestigation {
   }
   GetWorkflowAt(index) {
     const this$ = this;
-    return this$.Workflows[index];
+    return item$1(index, this$.Workflows);
   }
   static getWorkflowAt(index) {
     return (inv) => {
@@ -3296,7 +3539,7 @@ class ArcInvestigation {
     const this$ = this;
     const matchValue = this$.TryGetWorkflow(workflowIdentifier);
     if (matchValue == null) {
-      throw new Error(ArcTypesAux_ErrorMsgs_unableToFindWorkflowIdentifier(workflowIdentifier, this$.Identifier));
+      throw new Exception(ArcTypesAux_ErrorMsgs_unableToFindWorkflowIdentifier(workflowIdentifier, this$.Identifier));
     } else {
       return value(matchValue);
     }
@@ -3330,10 +3573,10 @@ class ArcInvestigation {
     const matchValue = tryFindIndex((x) => x.Identifier === workflow_1.Identifier, removeAt(index, this$.Workflows));
     if (matchValue == null) {
     } else {
-      throw new Error(`Cannot create workflow with name ${workflow_1.Identifier}, as workflow names must be unique and workflow at index ${value(matchValue)} has the same name.`);
+      throw new Exception(`Cannot create workflow with name ${workflow_1.Identifier}, as workflow names must be unique and workflow at index ${value(matchValue)} has the same name.`);
     }
     workflow.Investigation = this$;
-    this$.Workflows[index] = workflow;
+    setItem(this$.Workflows, index, workflow);
   }
   SetWorkflow(workflowIdentifier, workflow) {
     const this$ = this;
@@ -3360,18 +3603,18 @@ class ArcInvestigation {
   }
   get RunIdentifiers() {
     const this$ = this;
-    return toArray(map$1((x) => x.Identifier, this$.Runs));
+    return toArray(map((x) => x.Identifier, this$.Runs));
   }
   GetRunIndex(runIdentifier) {
     const this$ = this;
     const index = this$.Runs.findIndex((r) => r.Identifier === runIdentifier) | 0;
     if (index === -1) {
-      throw new Error(`Unable to find run with specified identifier '${runIdentifier}'!`);
+      throw new Exception(concat("Unable to find run with specified identifier '", runIdentifier, "'!"));
     }
     return index | 0;
   }
   static getRunIndex(runIdentifier) {
-    return (inv) => inv.GetRunIndex(runIdentifier);
+    return (inv) => inv.GetRunIndex(runIdentifier) | 0;
   }
   AddRun(run) {
     const this$ = this;
@@ -3379,7 +3622,7 @@ class ArcInvestigation {
     const matchValue = tryFindIndex((x) => x.Identifier === run_1.Identifier, this$.Runs);
     if (matchValue == null) {
     } else {
-      throw new Error(`Cannot create run with name ${run_1.Identifier}, as run names must be unique and run at index ${value(matchValue)} has the same name.`);
+      throw new Exception(`Cannot create run with name ${run_1.Identifier}, as run names must be unique and run at index ${value(matchValue)} has the same name.`);
     }
     run.Investigation = this$;
     void this$.Runs.push(run);
@@ -3428,7 +3671,7 @@ class ArcInvestigation {
   }
   GetRunAt(index) {
     const this$ = this;
-    return this$.Runs[index];
+    return item$1(index, this$.Runs);
   }
   static getRunAt(index) {
     return (inv) => {
@@ -3440,7 +3683,7 @@ class ArcInvestigation {
     const this$ = this;
     const matchValue = this$.TryGetRun(runIdentifier);
     if (matchValue == null) {
-      throw new Error(ArcTypesAux_ErrorMsgs_unableToFindRunIdentifier(runIdentifier, this$.Identifier));
+      throw new Exception(ArcTypesAux_ErrorMsgs_unableToFindRunIdentifier(runIdentifier, this$.Identifier));
     } else {
       return value(matchValue);
     }
@@ -3474,10 +3717,10 @@ class ArcInvestigation {
     const matchValue = tryFindIndex((x) => x.Identifier === run_1.Identifier, removeAt(index, this$.Runs));
     if (matchValue == null) {
     } else {
-      throw new Error(`Cannot create run with name ${run_1.Identifier}, as run names must be unique and run at index ${value(matchValue)} has the same name.`);
+      throw new Exception(`Cannot create run with name ${run_1.Identifier}, as run names must be unique and run at index ${value(matchValue)} has the same name.`);
     }
     run.Investigation = this$;
-    this$.Runs[index] = run;
+    setItem(this$.Runs, index, run);
   }
   SetRun(runIdentifier, run) {
     const this$ = this;
@@ -3498,6 +3741,9 @@ class ArcInvestigation {
       return copy;
     };
   }
+  /**
+   * Returns all fully distinct Contacts/Performers from assays/studies/investigation.
+   */
   GetAllPersons() {
     const this$ = this;
     const persons = [];
@@ -3540,9 +3786,12 @@ class ArcInvestigation {
     addRangeInPlace(this$.Contacts, persons);
     return Array_distinct(Array.from(persons), {
       Equals: equals,
-      GetHashCode: safeHash
+      GetHashCode: (x) => safeHash(x) | 0
     });
   }
+  /**
+   * Returns all fully distinct Contacts/Performers from assays/studies/investigation unfiltered.
+   */
   GetAllPublications() {
     const this$ = this;
     const pubs = [];
@@ -3558,9 +3807,12 @@ class ArcInvestigation {
     addRangeInPlace(this$.Publications, pubs);
     return Array_distinct(Array.from(pubs), {
       Equals: equals,
-      GetHashCode: safeHash
+      GetHashCode: (x) => safeHash(x) | 0
     });
   }
+  /**
+   * Deregisters assays not found in ArcInvestigation.Assays from all studies.
+   */
   DeregisterMissingAssays() {
     const this$ = this;
     const inv = this$;
@@ -3576,9 +3828,9 @@ class ArcInvestigation {
             const registeredAssay = enumerator_1["System.Collections.Generic.IEnumerator`1.get_Current"]();
             if (!contains(registeredAssay, existingAssays, {
               Equals: (x, y) => x === y,
-              GetHashCode: stringHash
+              GetHashCode: (x) => stringHash(x) | 0
             })) {
-              const value_1 = study.DeregisterAssay(registeredAssay);
+              study.DeregisterAssay(registeredAssay);
             }
           }
         } finally {
@@ -3596,8 +3848,19 @@ class ArcInvestigation {
       return copy;
     };
   }
+  /**
+   * Updates the IOtypes of the IO columns (Input, Output) across all tables in the investigation if possible.
+   * 
+   * If an entity (Row Value of IO Column) with the same name as an entity with a higher IOType specifity is found, the IOType of the entity with the lower IOType specificity is updated.
+   * 
+   * E.g. In Table1, there is a column "Output [Sample Name]" with an entity "Sample1". In Table2, there is a column "Input [Source Name]" with the same entity "Sample1". By equality of the entities, the IOType of the Input column in Table2 is inferred to be Sample, resulting in "Input [Sample Name]".
+   * 
+   * E.g. RawDataFile is more specific than Source, but less specific than DerivedDataFile.
+   * 
+   * E.g. Sample is equally specific to RawDataFile.
+   */
   UpdateIOTypeByEntityID() {
-    let collection;
+    let collection = void 0;
     const this$ = this;
     const ioMap = ArcTablesAux_getIOMap((collection = toList(delay(() => append(collect((study) => study.Tables, this$.Studies), delay(() => append(collect((assay) => assay.Tables, this$.Assays), delay(() => collect((run) => run.Tables, this$.Runs))))))), Array.from(collection)));
     let enumerator = getEnumerator(this$.Studies);
@@ -3683,7 +3946,7 @@ class ArcInvestigation {
     return new ArcInvestigation(this$.Identifier, unwrap(this$.Title), unwrap(this$.Description), unwrap(this$.SubmissionDate), unwrap(this$.PublicReleaseDate), nextOntologySourceReferences, nextPublications, nextContacts, nextAssays, nextStudies, nextWorkflows, nextRuns, nextStudyIdentifiers, nextComments, nextRemarks);
   }
   StructurallyEquals(other) {
-    let a, b, a_1, b_1, a_2, b_2, a_3, b_3, a_4, b_4, a_5, b_5, a_6, b_6, a_7, b_7, a_8, b_8, a_9, b_9;
+    let a = void 0, b = void 0, a_1 = void 0, b_1 = void 0, a_2 = void 0, b_2 = void 0, a_3 = void 0, b_3 = void 0, a_4 = void 0, b_4 = void 0, a_5 = void 0, b_5 = void 0, a_6 = void 0, b_6 = void 0, a_7 = void 0, b_7 = void 0, a_8 = void 0, b_8 = void 0, a_9 = void 0, b_9 = void 0;
     const this$ = this;
     return forAll((x) => x === true, [this$.Identifier === other.Identifier, equals(this$.Title, other.Title), equals(this$.Description, other.Description), equals(this$.SubmissionDate, other.SubmissionDate), equals(this$.PublicReleaseDate, other.PublicReleaseDate), (a = this$.Publications, b = other.Publications, length(a) === length(b) && fold((acc, e) => {
       if (acc) {
@@ -3691,62 +3954,67 @@ class ArcInvestigation {
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_1) => equals(item(i_1, a), item(i_1, b)), rangeDouble(0, 1, length(a) - 1)))))), (a_1 = this$.Contacts, b_1 = other.Contacts, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
+    }, true, toList(delay(() => map((i_1) => equals(item(i_1, a), item(i_1, b)), rangeDouble(0, 1, length(a) - 1)))))), (a_1 = this$.Contacts, b_1 = other.Contacts, length(a_1) === length(b_1) && fold((acc_1, e_1) => {
       if (acc_1) {
         return e_1;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.OntologySourceReferences, b_2 = other.OntologySourceReferences, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
+    }, true, toList(delay(() => map((i_2) => equals(item(i_2, a_1), item(i_2, b_1)), rangeDouble(0, 1, length(a_1) - 1)))))), (a_2 = this$.OntologySourceReferences, b_2 = other.OntologySourceReferences, length(a_2) === length(b_2) && fold((acc_2, e_2) => {
       if (acc_2) {
         return e_2;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1)))))), (a_3 = this$.Assays, b_3 = other.Assays, length(a_3) === length(b_3) && fold((acc_3, e_3) => {
+    }, true, toList(delay(() => map((i_3) => equals(item(i_3, a_2), item(i_3, b_2)), rangeDouble(0, 1, length(a_2) - 1)))))), (a_3 = this$.Assays, b_3 = other.Assays, length(a_3) === length(b_3) && fold((acc_3, e_3) => {
       if (acc_3) {
         return e_3;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_4) => equals(item(i_4, a_3), item(i_4, b_3)), rangeDouble(0, 1, length(a_3) - 1)))))), (a_4 = this$.Studies, b_4 = other.Studies, length(a_4) === length(b_4) && fold((acc_4, e_4) => {
+    }, true, toList(delay(() => map((i_4) => equals(item(i_4, a_3), item(i_4, b_3)), rangeDouble(0, 1, length(a_3) - 1)))))), (a_4 = this$.Studies, b_4 = other.Studies, length(a_4) === length(b_4) && fold((acc_4, e_4) => {
       if (acc_4) {
         return e_4;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_5) => equals(item(i_5, a_4), item(i_5, b_4)), rangeDouble(0, 1, length(a_4) - 1)))))), (a_5 = this$.Workflows, b_5 = other.Workflows, length(a_5) === length(b_5) && fold((acc_5, e_5) => {
+    }, true, toList(delay(() => map((i_5) => equals(item(i_5, a_4), item(i_5, b_4)), rangeDouble(0, 1, length(a_4) - 1)))))), (a_5 = this$.Workflows, b_5 = other.Workflows, length(a_5) === length(b_5) && fold((acc_5, e_5) => {
       if (acc_5) {
         return e_5;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_6) => equals(item(i_6, a_5), item(i_6, b_5)), rangeDouble(0, 1, length(a_5) - 1)))))), (a_6 = this$.Runs, b_6 = other.Runs, length(a_6) === length(b_6) && fold((acc_6, e_6) => {
+    }, true, toList(delay(() => map((i_6) => equals(item(i_6, a_5), item(i_6, b_5)), rangeDouble(0, 1, length(a_5) - 1)))))), (a_6 = this$.Runs, b_6 = other.Runs, length(a_6) === length(b_6) && fold((acc_6, e_6) => {
       if (acc_6) {
         return e_6;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_7) => equals(item(i_7, a_6), item(i_7, b_6)), rangeDouble(0, 1, length(a_6) - 1)))))), (a_7 = this$.RegisteredStudyIdentifiers, b_7 = other.RegisteredStudyIdentifiers, length(a_7) === length(b_7) && fold((acc_7, e_7) => {
+    }, true, toList(delay(() => map((i_7) => equals(item(i_7, a_6), item(i_7, b_6)), rangeDouble(0, 1, length(a_6) - 1)))))), (a_7 = this$.RegisteredStudyIdentifiers, b_7 = other.RegisteredStudyIdentifiers, length(a_7) === length(b_7) && fold((acc_7, e_7) => {
       if (acc_7) {
         return e_7;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_8) => item(i_8, a_7) === item(i_8, b_7), rangeDouble(0, 1, length(a_7) - 1)))))), (a_8 = this$.Comments, b_8 = other.Comments, length(a_8) === length(b_8) && fold((acc_8, e_8) => {
+    }, true, toList(delay(() => map((i_8) => item(i_8, a_7) === item(i_8, b_7), rangeDouble(0, 1, length(a_7) - 1)))))), (a_8 = this$.Comments, b_8 = other.Comments, length(a_8) === length(b_8) && fold((acc_8, e_8) => {
       if (acc_8) {
         return e_8;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_9) => equals(item(i_9, a_8), item(i_9, b_8)), rangeDouble(0, 1, length(a_8) - 1)))))), (a_9 = this$.Remarks, b_9 = other.Remarks, length(a_9) === length(b_9) && fold((acc_9, e_9) => {
+    }, true, toList(delay(() => map((i_9) => equals(item(i_9, a_8), item(i_9, b_8)), rangeDouble(0, 1, length(a_8) - 1)))))), (a_9 = this$.Remarks, b_9 = other.Remarks, length(a_9) === length(b_9) && fold((acc_9, e_9) => {
       if (acc_9) {
         return e_9;
       } else {
         return false;
       }
-    }, true, toList(delay(() => map$1((i_10) => equals(item(i_10, a_9), item(i_10, b_9)), rangeDouble(0, 1, length(a_9) - 1))))))]);
+    }, true, toList(delay(() => map((i_10) => equals(item(i_10, a_9), item(i_10, b_9)), rangeDouble(0, 1, length(a_9) - 1))))))]);
   }
+  /**
+   * Use this function to check if this ArcInvestigation and the input ArcInvestigation refer to the same object.
+   * 
+   * If true, updating one will update the other due to mutability.
+   */
   ReferenceEquals(other) {
     const this$ = this;
     return this$ === other;
@@ -3771,7 +4039,7 @@ class ArcInvestigation {
     return toText(printf("ArcInvestigation {\r\n    Identifier = %A,\r\n    Title = %A,\r\n    Description = %A,\r\n    SubmissionDate = %A,\r\n    PublicReleaseDate = %A,\r\n    OntologySourceReferences = %A,\r\n    Publications = %A,\r\n    Contacts = %A,\r\n    Assays = %A,\r\n    Studies = %A,\r\n    Workflows = %A,\r\n    Runs = %A,\r\n    RegisteredStudyIdentifiers = %A,\r\n    Comments = %A,\r\n    Remarks = %A,\r\n}"))(arg)(arg_1)(arg_2)(arg_3)(arg_4)(arg_5)(arg_6)(arg_7)(arg_8)(arg_9)(arg_10)(arg_11)(arg_12)(arg_13)(arg_14);
   }
   Equals(other) {
-    let i;
+    let i = void 0;
     const this$ = this;
     return other instanceof ArcInvestigation && (i = other, this$.StructurallyEquals(i));
   }