@saibolla/ada 0.1.2

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Files changed (1432) hide show
  1. package/.ada/SYSTEM.md +81 -0
  2. package/.ada/agents/researcher.md +69 -0
  3. package/.ada/agents/reviewer.md +92 -0
  4. package/.ada/agents/verifier.md +45 -0
  5. package/.ada/agents/writer.md +54 -0
  6. package/.ada/settings.json +32 -0
  7. package/.ada/themes/ada.json +85 -0
  8. package/.env.example +31 -0
  9. package/AGENTS.md +79 -0
  10. package/LICENSE +191 -0
  11. package/README.md +188 -0
  12. package/bin/ada.js +26 -0
  13. package/dist/bootstrap/sync.js +143 -0
  14. package/dist/cli.js +404 -0
  15. package/dist/config/paths.js +32 -0
  16. package/dist/index.js +10 -0
  17. package/dist/model/catalog.js +255 -0
  18. package/dist/model/commands.js +180 -0
  19. package/dist/pi/launch.js +33 -0
  20. package/dist/pi/package-presets.js +55 -0
  21. package/dist/pi/runtime.js +81 -0
  22. package/dist/pi/settings.js +108 -0
  23. package/dist/pi/web-access.js +74 -0
  24. package/dist/search/commands.js +12 -0
  25. package/dist/setup/doctor.js +126 -0
  26. package/dist/setup/preview.js +117 -0
  27. package/dist/setup/prompts.js +34 -0
  28. package/dist/setup/setup.js +98 -0
  29. package/dist/setup/update.js +133 -0
  30. package/dist/system/executables.js +38 -0
  31. package/dist/system/node-version.js +31 -0
  32. package/dist/system/open-url.js +35 -0
  33. package/dist/system/promise-polyfill.js +12 -0
  34. package/dist/ui/terminal.js +64 -0
  35. package/dist/web/launch.js +48 -0
  36. package/dist/web-search.js +1 -0
  37. package/extensions/docparser/constants.ts +62 -0
  38. package/extensions/docparser/deps.ts +584 -0
  39. package/extensions/docparser/doctor.ts +353 -0
  40. package/extensions/docparser/index.ts +9 -0
  41. package/extensions/docparser/input.ts +230 -0
  42. package/extensions/docparser/request.ts +67 -0
  43. package/extensions/docparser/schema.ts +82 -0
  44. package/extensions/docparser/tool.ts +305 -0
  45. package/extensions/docparser/types.ts +99 -0
  46. package/extensions/research-tools/alpha.ts +107 -0
  47. package/extensions/research-tools/header.ts +284 -0
  48. package/extensions/research-tools/help.ts +93 -0
  49. package/extensions/research-tools/project-scaffold.ts +64 -0
  50. package/extensions/research-tools/project.ts +123 -0
  51. package/extensions/research-tools/shared.ts +16 -0
  52. package/extensions/research-tools.ts +42 -0
  53. package/logo.d.mts +3 -0
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  55. package/metadata/commands.d.mts +46 -0
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  63. package/prompts/jobs.md +16 -0
  64. package/prompts/litreview.md +18 -0
  65. package/prompts/log.md +14 -0
  66. package/prompts/replicate.md +24 -0
  67. package/prompts/review.md +18 -0
  68. package/prompts/watch.md +16 -0
  69. package/scripts/build-native-bundle.mjs +349 -0
  70. package/scripts/check-node-version.mjs +35 -0
  71. package/scripts/patch-embedded-pi.mjs +588 -0
  72. package/scripts/prepare-runtime-workspace.mjs +162 -0
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+ # OpenRouter Setup Guide
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+
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+ Complete guide to setting up and using OpenRouter for Perplexity model access.
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+
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+ ## What is OpenRouter?
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+
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+ OpenRouter is a unified API gateway that provides access to 100+ AI models from various providers through a single API interface. It offers:
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+
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+ - **Single API key**: Access multiple models with one key
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+ - **Unified format**: OpenAI-compatible API format
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+ - **Cost tracking**: Built-in usage monitoring and billing
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+ - **Model routing**: Intelligent fallback and load balancing
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+ - **Pay-as-you-go**: No subscriptions, pay only for what you use
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+
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+ For Perplexity models specifically, OpenRouter provides exclusive access to certain models like Sonar Pro Search.
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+
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+ ## Getting Started
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+
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+ ### Step 1: Create OpenRouter Account
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+
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+ 1. Visit https://openrouter.ai/
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+ 2. Click "Sign Up" in the top right
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+ 3. Sign up with Google, GitHub, or email
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+ 4. Verify your email if using email signup
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+
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+ ### Step 2: Add Payment Method
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+
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+ OpenRouter uses pay-as-you-go billing:
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+
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+ 1. Navigate to https://openrouter.ai/account
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+ 2. Click "Credits" tab
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+ 3. Add a payment method (credit card)
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+ 4. Add initial credits (minimum $5 recommended)
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+ 5. Optionally set up auto-recharge
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+
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+ **Pricing notes:**
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+ - Models have different per-token costs
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+ - See https://openrouter.ai/perplexity for Perplexity pricing
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+ - Monitor usage at https://openrouter.ai/activity
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+
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+ ### Step 3: Generate API Key
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+
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+ 1. Go to https://openrouter.ai/keys
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+ 2. Click "Create Key"
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+ 3. Give your key a descriptive name (e.g., "perplexity-search-skill")
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+ 4. Optionally set usage limits for safety
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+ 5. Copy the key (starts with `sk-or-v1-...`)
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+ 6. **Important**: Save this key securely - you can't view it again!
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+
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+ **Security tips:**
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+ - Never share your API key publicly
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+ - Don't commit keys to version control
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+ - Use separate keys for different projects
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+ - Set usage limits to prevent unexpected charges
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+ - Rotate keys periodically
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+
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+ ### Step 4: Configure Environment
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+
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+ You have two options for setting up your API key:
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+
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+ #### Option A: Environment Variable (Recommended)
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+
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+ **Linux/macOS:**
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+ ```bash
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+ export OPENROUTER_API_KEY='sk-or-v1-your-key-here'
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+ ```
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+
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+ To make it permanent, add to your shell profile:
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+ ```bash
70
+ # For bash: Add to ~/.bashrc or ~/.bash_profile
71
+ echo 'export OPENROUTER_API_KEY="sk-or-v1-your-key-here"' >> ~/.bashrc
72
+ source ~/.bashrc
73
+
74
+ # For zsh: Add to ~/.zshrc
75
+ echo 'export OPENROUTER_API_KEY="sk-or-v1-your-key-here"' >> ~/.zshrc
76
+ source ~/.zshrc
77
+ ```
78
+
79
+ **Windows (PowerShell):**
80
+ ```powershell
81
+ $env:OPENROUTER_API_KEY = "sk-or-v1-your-key-here"
82
+ ```
83
+
84
+ To make it permanent:
85
+ ```powershell
86
+ [System.Environment]::SetEnvironmentVariable('OPENROUTER_API_KEY', 'sk-or-v1-your-key-here', 'User')
87
+ ```
88
+
89
+ #### Option B: .env File
90
+
91
+ Create a `.env` file in your project directory:
92
+
93
+ ```bash
94
+ # Create .env file
95
+ cat > .env << EOF
96
+ OPENROUTER_API_KEY=sk-or-v1-your-key-here
97
+ EOF
98
+ ```
99
+
100
+ Or use the setup script:
101
+ ```bash
102
+ python scripts/setup_env.py --api-key sk-or-v1-your-key-here
103
+ ```
104
+
105
+ Then load it before running scripts:
106
+ ```bash
107
+ # Load environment variables from .env
108
+ source .env
109
+
110
+ # Or use python-dotenv
111
+ pip install python-dotenv
112
+ ```
113
+
114
+ **Using python-dotenv in scripts:**
115
+ ```python
116
+ from dotenv import load_dotenv
117
+ load_dotenv() # Loads .env file automatically
118
+
119
+ import os
120
+ api_key = os.environ.get("OPENROUTER_API_KEY")
121
+ ```
122
+
123
+ ### Step 5: Install Dependencies
124
+
125
+ Install LiteLLM using uv:
126
+
127
+ ```bash
128
+ uv pip install litellm
129
+ ```
130
+
131
+ Or with regular pip:
132
+ ```bash
133
+ pip install litellm
134
+ ```
135
+
136
+ **Optional dependencies:**
137
+ ```bash
138
+ # For .env file support
139
+ uv pip install python-dotenv
140
+
141
+ # For additional features
142
+ uv pip install litellm[proxy] # If using LiteLLM proxy server
143
+ ```
144
+
145
+ ### Step 6: Verify Setup
146
+
147
+ Test your configuration:
148
+
149
+ ```bash
150
+ # Using the setup script
151
+ python scripts/setup_env.py --validate
152
+
153
+ # Or using the search script
154
+ python scripts/perplexity_search.py --check-setup
155
+ ```
156
+
157
+ You should see:
158
+ ```
159
+ ✓ OPENROUTER_API_KEY is set (sk-or-v1-...xxxx)
160
+ ✓ LiteLLM is installed (version X.X.X)
161
+ ✓ Setup is complete! You're ready to use Perplexity Search.
162
+ ```
163
+
164
+ ### Step 7: Test Your First Search
165
+
166
+ Run a simple test query:
167
+
168
+ ```bash
169
+ python scripts/perplexity_search.py "What is CRISPR gene editing?"
170
+ ```
171
+
172
+ Expected output:
173
+ ```
174
+ ================================================================================
175
+ ANSWER
176
+ ================================================================================
177
+ CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a
178
+ revolutionary gene editing technology that allows precise modifications to DNA...
179
+ [detailed answer continues]
180
+ ================================================================================
181
+ ```
182
+
183
+ ## Usage Monitoring
184
+
185
+ ### Check Your Usage
186
+
187
+ Monitor your OpenRouter usage and costs:
188
+
189
+ 1. Visit https://openrouter.ai/activity
190
+ 2. View requests, tokens, and costs
191
+ 3. Filter by date range, model, or key
192
+ 4. Export usage data for analysis
193
+
194
+ ### Set Usage Limits
195
+
196
+ Protect against unexpected charges:
197
+
198
+ 1. Go to https://openrouter.ai/keys
199
+ 2. Click on your key
200
+ 3. Set "Rate limit" (requests per minute)
201
+ 4. Set "Spending limit" (maximum total spend)
202
+ 5. Enable "Auto-recharge" with limit if desired
203
+
204
+ **Recommended limits for development:**
205
+ - Rate limit: 10-20 requests per minute
206
+ - Spending limit: $10-50 depending on usage
207
+
208
+ ### Cost Optimization
209
+
210
+ Tips for reducing costs:
211
+
212
+ 1. **Choose appropriate models**: Use Sonar for simple queries, not Sonar Pro Search
213
+ 2. **Set max_tokens**: Limit response length with `--max-tokens` parameter
214
+ 3. **Batch queries**: Combine multiple simple questions when possible
215
+ 4. **Monitor usage**: Check costs daily during heavy development
216
+ 5. **Use caching**: Store results for repeated queries
217
+
218
+ ## Troubleshooting
219
+
220
+ ### Error: "OpenRouter API key not configured"
221
+
222
+ **Cause**: Environment variable not set
223
+
224
+ **Solution**:
225
+ ```bash
226
+ # Check if variable is set
227
+ echo $OPENROUTER_API_KEY
228
+
229
+ # If empty, set it
230
+ export OPENROUTER_API_KEY='sk-or-v1-your-key-here'
231
+
232
+ # Or use setup script
233
+ python scripts/setup_env.py --api-key sk-or-v1-your-key-here
234
+ ```
235
+
236
+ ### Error: "Invalid API key"
237
+
238
+ **Causes**:
239
+ - Key was deleted or revoked
240
+ - Key has expired
241
+ - Typo in the key
242
+ - Wrong key format
243
+
244
+ **Solutions**:
245
+ 1. Verify key at https://openrouter.ai/keys
246
+ 2. Check for extra spaces or quotes
247
+ 3. Generate a new key if needed
248
+ 4. Ensure key starts with `sk-or-v1-`
249
+
250
+ ### Error: "Insufficient credits"
251
+
252
+ **Cause**: OpenRouter account has run out of credits
253
+
254
+ **Solution**:
255
+ 1. Go to https://openrouter.ai/account
256
+ 2. Click "Credits" tab
257
+ 3. Add more credits
258
+ 4. Consider enabling auto-recharge
259
+
260
+ ### Error: "Rate limit exceeded"
261
+
262
+ **Cause**: Too many requests in a short time
263
+
264
+ **Solutions**:
265
+ 1. Wait a few seconds before retrying
266
+ 2. Increase rate limit at https://openrouter.ai/keys
267
+ 3. Implement exponential backoff in code
268
+ 4. Batch requests or reduce frequency
269
+
270
+ ### Error: "Model not found"
271
+
272
+ **Cause**: Incorrect model name or model no longer available
273
+
274
+ **Solution**:
275
+ 1. Check available models at https://openrouter.ai/models
276
+ 2. Use correct format: `openrouter/perplexity/sonar-pro`
277
+ 3. Verify model is still supported
278
+
279
+ ### Error: "LiteLLM not installed"
280
+
281
+ **Cause**: LiteLLM package is not installed
282
+
283
+ **Solution**:
284
+ ```bash
285
+ uv pip install litellm
286
+ ```
287
+
288
+ ### Import Error with LiteLLM
289
+
290
+ **Cause**: Python path issues or version conflicts
291
+
292
+ **Solutions**:
293
+ 1. Verify installation: `pip list | grep litellm`
294
+ 2. Reinstall: `uv pip install --force-reinstall litellm`
295
+ 3. Check Python version: `python --version` (requires 3.8+)
296
+ 4. Use virtual environment to avoid conflicts
297
+
298
+ ## Advanced Configuration
299
+
300
+ ### Using Multiple Keys
301
+
302
+ For different projects or team members:
303
+
304
+ ```bash
305
+ # Project 1
306
+ export OPENROUTER_API_KEY='sk-or-v1-project1-key'
307
+
308
+ # Project 2
309
+ export OPENROUTER_API_KEY='sk-or-v1-project2-key'
310
+ ```
311
+
312
+ Or use .env files in different directories.
313
+
314
+ ### Custom Base URL
315
+
316
+ If using OpenRouter proxy or custom endpoint:
317
+
318
+ ```python
319
+ from litellm import completion
320
+
321
+ response = completion(
322
+ model="openrouter/perplexity/sonar-pro",
323
+ messages=[{"role": "user", "content": "query"}],
324
+ api_base="https://custom-endpoint.com/v1" # Custom URL
325
+ )
326
+ ```
327
+
328
+ ### Request Headers
329
+
330
+ Add custom headers for tracking:
331
+
332
+ ```python
333
+ from litellm import completion
334
+
335
+ response = completion(
336
+ model="openrouter/perplexity/sonar-pro",
337
+ messages=[{"role": "user", "content": "query"}],
338
+ extra_headers={
339
+ "HTTP-Referer": "https://your-app.com",
340
+ "X-Title": "Your App Name"
341
+ }
342
+ )
343
+ ```
344
+
345
+ ### Timeout Configuration
346
+
347
+ Set custom timeouts for long-running queries:
348
+
349
+ ```python
350
+ from litellm import completion
351
+
352
+ response = completion(
353
+ model="openrouter/perplexity/sonar-pro-search",
354
+ messages=[{"role": "user", "content": "complex query"}],
355
+ timeout=120 # 120 seconds timeout
356
+ )
357
+ ```
358
+
359
+ ## Security Best Practices
360
+
361
+ ### API Key Management
362
+
363
+ 1. **Never commit keys**: Add `.env` to `.gitignore`
364
+ 2. **Use key rotation**: Rotate keys every 3-6 months
365
+ 3. **Separate keys**: Different keys for dev/staging/production
366
+ 4. **Monitor usage**: Check for unauthorized access
367
+ 5. **Set limits**: Configure spending and rate limits
368
+
369
+ ### .gitignore Template
370
+
371
+ Add to your `.gitignore`:
372
+ ```
373
+ # Environment variables
374
+ .env
375
+ .env.local
376
+ .env.*.local
377
+
378
+ # API keys
379
+ *api_key*
380
+ *apikey*
381
+ *.key
382
+
383
+ # Sensitive configs
384
+ config/secrets.yaml
385
+ ```
386
+
387
+ ### Key Revocation
388
+
389
+ If a key is compromised:
390
+
391
+ 1. Go to https://openrouter.ai/keys immediately
392
+ 2. Click "Delete" on the compromised key
393
+ 3. Generate a new key
394
+ 4. Update all applications using the old key
395
+ 5. Review usage logs for unauthorized access
396
+ 6. Contact OpenRouter support if needed
397
+
398
+ ## FAQs
399
+
400
+ **Q: How much does it cost to use Perplexity via OpenRouter?**
401
+
402
+ A: Pricing varies by model. Sonar is cheapest (~$0.001-0.002 per query), Sonar Pro is moderate (~$0.002-0.005), and Sonar Pro Search is most expensive (~$0.02-0.05+ per query). See https://openrouter.ai/perplexity for exact pricing.
403
+
404
+ **Q: Do I need a separate Perplexity API key?**
405
+
406
+ A: No! OpenRouter provides access to Perplexity models using only your OpenRouter key.
407
+
408
+ **Q: Can I use OpenRouter for other models besides Perplexity?**
409
+
410
+ A: Yes! OpenRouter provides access to 100+ models from OpenAI, Anthropic, Google, Meta, and more through the same API key.
411
+
412
+ **Q: Is there a free tier?**
413
+
414
+ A: OpenRouter requires payment, but offers very competitive pricing. Initial $5 credit should last for extensive testing.
415
+
416
+ **Q: How do I cancel my OpenRouter account?**
417
+
418
+ A: Contact OpenRouter support. Note that unused credits may not be refundable.
419
+
420
+ **Q: Can I use OpenRouter in production applications?**
421
+
422
+ A: Yes, OpenRouter is designed for production use with robust infrastructure, SLAs, and enterprise support available.
423
+
424
+ ## Resources
425
+
426
+ **Official Documentation:**
427
+ - OpenRouter: https://openrouter.ai/docs
428
+ - Perplexity Models: https://openrouter.ai/perplexity
429
+ - LiteLLM: https://docs.litellm.ai/
430
+
431
+ **Account Management:**
432
+ - Dashboard: https://openrouter.ai/account
433
+ - API Keys: https://openrouter.ai/keys
434
+ - Usage: https://openrouter.ai/activity
435
+ - Billing: https://openrouter.ai/credits
436
+
437
+ **Community:**
438
+ - OpenRouter Discord: https://discord.gg/openrouter
439
+ - GitHub Issues: https://github.com/OpenRouter
440
+ - LiteLLM GitHub: https://github.com/BerriAI/litellm
441
+
442
+ ## Summary
443
+
444
+ Setting up OpenRouter for Perplexity access involves:
445
+
446
+ 1. Create account at https://openrouter.ai
447
+ 2. Add payment method and credits
448
+ 3. Generate API key at https://openrouter.ai/keys
449
+ 4. Set `OPENROUTER_API_KEY` environment variable
450
+ 5. Install LiteLLM: `uv pip install litellm`
451
+ 6. Verify setup: `python scripts/setup_env.py --validate`
452
+ 7. Start searching: `python scripts/perplexity_search.py "your query"`
453
+
454
+ Monitor usage and costs regularly to optimize your spending and ensure security.
@@ -0,0 +1,258 @@
1
+ # Search Strategies for Perplexity
2
+
3
+ Best practices and strategies for crafting effective search queries with Perplexity models.
4
+
5
+ ## Query Design Principles
6
+
7
+ ### Be Specific and Detailed
8
+
9
+ Better results come from specific, well-structured queries rather than broad questions.
10
+
11
+ **Good examples:**
12
+ - "What are the latest clinical trial results for CAR-T cell therapy in treating B-cell lymphoma published in 2024?"
13
+ - "Compare the efficacy and safety profiles of mRNA vaccines versus viral vector vaccines for COVID-19"
14
+ - "Explain the mechanism of CRISPR-Cas9 off-target effects and current mitigation strategies"
15
+
16
+ **Bad examples:**
17
+ - "Tell me about cancer treatment" (too broad)
18
+ - "CRISPR" (too vague)
19
+ - "vaccines" (lacks specificity)
20
+
21
+ ### Structure Complex Queries
22
+
23
+ Break complex questions into clear components:
24
+
25
+ 1. **Topic**: What is the main subject?
26
+ 2. **Scope**: What specific aspect are you interested in?
27
+ 3. **Context**: What time frame, domain, or constraints apply?
28
+ 4. **Output**: What format or type of answer do you need?
29
+
30
+ **Example:**
31
+ ```
32
+ Topic: Protein folding prediction
33
+ Scope: AlphaFold3 improvements over AlphaFold2
34
+ Context: Published research from 2023-2024
35
+ Output: Technical comparison with specific accuracy metrics
36
+ ```
37
+
38
+ **Query:**
39
+ "What improvements does AlphaFold3 offer over AlphaFold2 for protein structure prediction, according to research published between 2023 and 2024? Include specific accuracy metrics and benchmarks."
40
+
41
+ ## Domain-Specific Search Patterns
42
+
43
+ ### Scientific Literature Search
44
+
45
+ For scientific queries, include:
46
+ - Specific terminology and concepts
47
+ - Time constraints (recent publications)
48
+ - Methodology or study types of interest
49
+ - Journal quality or domain constraints
50
+
51
+ **Template:**
52
+ "What does recent research (2023-2024) say about [specific scientific concept] in [domain]? Focus on [peer-reviewed/preprint] studies and include [specific metrics/findings]."
53
+
54
+ **Example:**
55
+ "What does recent research (2023-2024) say about the role of gut microbiome in Parkinson's disease? Focus on peer-reviewed studies and include specific bacterial species identified."
56
+
57
+ ### Technical/Engineering Search
58
+
59
+ For technical queries, specify:
60
+ - Technology stack or framework
61
+ - Use case or application context
62
+ - Version requirements
63
+ - Performance or implementation constraints
64
+
65
+ **Template:**
66
+ "How to [specific technical task] using [technology/framework] for [use case]? Include [implementation details/performance considerations]."
67
+
68
+ **Example:**
69
+ "How to implement real-time data streaming from Kafka to PostgreSQL using Python? Include considerations for handling backpressure and ensuring exactly-once semantics."
70
+
71
+ ### Medical/Clinical Search
72
+
73
+ For medical queries, include:
74
+ - Specific conditions, treatments, or interventions
75
+ - Patient population or demographics
76
+ - Outcomes of interest
77
+ - Evidence level (RCTs, meta-analyses, etc.)
78
+
79
+ **Template:**
80
+ "What is the evidence for [intervention] in treating [condition] in [population]? Focus on [study types] and report [specific outcomes]."
81
+
82
+ **Example:**
83
+ "What is the evidence for intermittent fasting in managing type 2 diabetes in adults? Focus on randomized controlled trials and report HbA1c changes and weight loss outcomes."
84
+
85
+ ## Advanced Query Techniques
86
+
87
+ ### Comparative Analysis
88
+
89
+ For comparing multiple options:
90
+
91
+ **Template:**
92
+ "Compare [option A] versus [option B] for [use case] in terms of [criteria 1], [criteria 2], and [criteria 3]. Include [specific evidence or metrics]."
93
+
94
+ **Example:**
95
+ "Compare PyTorch versus TensorFlow for implementing transformer models in terms of ease of use, performance, and ecosystem support. Include benchmarks from recent studies."
96
+
97
+ ### Trend Analysis
98
+
99
+ For understanding trends over time:
100
+
101
+ **Template:**
102
+ "What are the key trends in [domain/topic] over the past [time period]? Highlight [specific aspects] and include [data or examples]."
103
+
104
+ **Example:**
105
+ "What are the key trends in single-cell RNA sequencing technology over the past 5 years? Highlight improvements in throughput, cost, and resolution, with specific examples."
106
+
107
+ ### Gap Identification
108
+
109
+ For finding research or knowledge gaps:
110
+
111
+ **Template:**
112
+ "What are the current limitations and open questions in [field/topic]? Focus on [specific aspects] and identify areas needing further research."
113
+
114
+ **Example:**
115
+ "What are the current limitations and open questions in quantum error correction? Focus on practical implementations and identify scalability challenges."
116
+
117
+ ### Mechanism Explanation
118
+
119
+ For understanding how things work:
120
+
121
+ **Template:**
122
+ "Explain the mechanism by which [process/phenomenon] occurs in [context]. Include [level of detail] and discuss [specific aspects]."
123
+
124
+ **Example:**
125
+ "Explain the mechanism by which mRNA vaccines induce immune responses. Include molecular details of translation, antigen presentation, and memory cell formation."
126
+
127
+ ## Query Refinement Strategies
128
+
129
+ ### Start Broad, Then Narrow
130
+
131
+ 1. **Initial query**: "Recent developments in cancer immunotherapy"
132
+ 2. **Refined query**: "Recent developments in checkpoint inhibitor combination therapies for melanoma"
133
+ 3. **Specific query**: "What are the clinical trial results for combining anti-PD-1 and anti-CTLA-4 checkpoint inhibitors in metastatic melanoma patients, published 2023-2024?"
134
+
135
+ ### Add Constraints Iteratively
136
+
137
+ Start with core query, then add constraints:
138
+
139
+ 1. **Base**: "Machine learning for drug discovery"
140
+ 2. **Add domain**: "Machine learning for small molecule drug discovery"
141
+ 3. **Add method**: "Deep learning approaches for small molecule property prediction"
142
+ 4. **Add context**: "Recent deep learning approaches (2023-2024) for predicting ADMET properties of small molecules, including accuracy benchmarks"
143
+
144
+ ### Specify Desired Output Format
145
+
146
+ Improve answers by specifying the output format:
147
+
148
+ - "Provide a step-by-step explanation..."
149
+ - "Summarize in bullet points..."
150
+ - "Create a comparison table of..."
151
+ - "List the top 5 approaches with pros and cons..."
152
+ - "Include specific numerical benchmarks and metrics..."
153
+
154
+ ## Common Pitfalls to Avoid
155
+
156
+ ### Too Vague
157
+
158
+ **Problem**: "Tell me about AI"
159
+ **Solution**: "What are the current state-of-the-art approaches for few-shot learning in computer vision as of 2024?"
160
+
161
+ ### Loaded Questions
162
+
163
+ **Problem**: "Why is drug X better than drug Y?"
164
+ **Solution**: "Compare the efficacy and safety profiles of drug X versus drug Y based on clinical trial evidence."
165
+
166
+ ### Multiple Unrelated Questions
167
+
168
+ **Problem**: "What is CRISPR and how do vaccines work and what causes cancer?"
169
+ **Solution**: Ask separate queries for each topic.
170
+
171
+ ### Assumed Knowledge Without Context
172
+
173
+ **Problem**: "What are the latest results?" (Latest results for what?)
174
+ **Solution**: "What are the latest clinical trial results for CAR-T cell therapy in treating acute lymphoblastic leukemia?"
175
+
176
+ ## Domain-Specific Keywords
177
+
178
+ ### Biomedical Research
179
+
180
+ Use precise terminology:
181
+ - "randomized controlled trial" instead of "study"
182
+ - "meta-analysis" instead of "review"
183
+ - "in vitro" vs "in vivo" vs "clinical"
184
+ - "peer-reviewed" for quality filter
185
+ - Specific gene/protein names (e.g., "BRCA1" not "breast cancer gene")
186
+
187
+ ### Computational/AI Research
188
+
189
+ Use technical terms:
190
+ - "transformer architecture" not "AI model"
191
+ - "few-shot learning" not "learning from limited data"
192
+ - "zero-shot" vs "few-shot" vs "fine-tuning"
193
+ - Specific model names (e.g., "GPT-4" not "language model")
194
+
195
+ ### Chemistry/Drug Discovery
196
+
197
+ Use IUPAC names and specific terms:
198
+ - "small molecule" vs "biologic"
199
+ - "pharmacokinetics" (ADME) vs "pharmacodynamics"
200
+ - Specific assay types (e.g., "IC50", "EC50")
201
+ - Drug names (generic vs brand)
202
+
203
+ ## Time-Constrained Searches
204
+
205
+ Perplexity searches real-time web data, making time constraints valuable:
206
+
207
+ **Templates:**
208
+ - "What papers were published in [journal] in [month/year] about [topic]?"
209
+ - "What are the latest developments (past 6 months) in [field]?"
210
+ - "What was announced at [conference] [year] regarding [topic]?"
211
+ - "What are the most recent clinical trial results (2024) for [treatment]?"
212
+
213
+ **Examples:**
214
+ - "What papers were published in Nature Medicine in January 2024 about long COVID?"
215
+ - "What are the latest developments (past 6 months) in large language model training efficiency?"
216
+ - "What was announced at NeurIPS 2023 regarding AI safety and alignment?"
217
+
218
+ ## Source Quality Considerations
219
+
220
+ For high-quality results, mention source preferences:
221
+
222
+ - "According to peer-reviewed publications..."
223
+ - "Based on clinical trial registries like clinicaltrials.gov..."
224
+ - "From authoritative sources such as Nature, Science, Cell..."
225
+ - "According to FDA/EMA approvals..."
226
+ - "Based on systematic reviews or meta-analyses..."
227
+
228
+ **Example:**
229
+ "What is the current understanding of microplastics' impact on human health according to peer-reviewed research published in high-impact journals since 2022?"
230
+
231
+ ## Iterative Search Workflow
232
+
233
+ For comprehensive research:
234
+
235
+ 1. **Broad overview**: Get general understanding
236
+ 2. **Specific deep-dives**: Focus on particular aspects
237
+ 3. **Comparative analysis**: Compare approaches/methods
238
+ 4. **Latest updates**: Find most recent developments
239
+ 5. **Critical evaluation**: Identify limitations and gaps
240
+
241
+ **Example workflow for "CAR-T cell therapy":**
242
+
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+ 1. "What is CAR-T cell therapy and how does it work?"
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+ 2. "What are the specific molecular mechanisms by which CAR-T cells recognize and kill cancer cells?"
245
+ 3. "Compare first-generation, second-generation, and third-generation CAR-T cell designs"
246
+ 4. "What are the latest clinical trial results for CAR-T therapy in treating solid tumors (2024)?"
247
+ 5. "What are the current limitations and challenges in CAR-T cell therapy, and what approaches are being investigated to address them?"
248
+
249
+ ## Summary
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+
251
+ Effective Perplexity searches require:
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+ 1. **Specificity**: Clear, detailed queries
253
+ 2. **Structure**: Well-organized questions with context
254
+ 3. **Terminology**: Domain-appropriate keywords
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+ 4. **Constraints**: Time frames, sources, output formats
256
+ 5. **Iteration**: Refine based on initial results
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+
258
+ The more specific and structured your query, the better and more relevant your results will be.