@pikaa-ai/pikaa 0.3.1 → 0.3.4
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/cli.js +1169 -601
- package/dist/index.js +525 -204
- package/package.json +5 -3
- package/skills/adaptyv/references/api-endpoints.md +0 -690
- package/skills/aeon/references/anomaly_detection.md +0 -154
- package/skills/aeon/references/classification.md +0 -144
- package/skills/aeon/references/clustering.md +0 -123
- package/skills/aeon/references/datasets_benchmarking.md +0 -392
- package/skills/aeon/references/distances.md +0 -256
- package/skills/aeon/references/forecasting.md +0 -109
- package/skills/aeon/references/networks.md +0 -289
- package/skills/aeon/references/regression.md +0 -118
- package/skills/aeon/references/segmentation.md +0 -163
- package/skills/aeon/references/similarity_search.md +0 -187
- package/skills/aeon/references/transformations.md +0 -246
- package/skills/analytical-method-validation/assets/validation-protocol-template.md +0 -106
- package/skills/analytical-method-validation/assets/validation-report-template.md +0 -116
- package/skills/analytical-method-validation/references/compendial-and-clsi.md +0 -96
- package/skills/analytical-method-validation/references/framework-selection.md +0 -87
- package/skills/analytical-method-validation/references/ich-m10-bioanalytical.md +0 -123
- package/skills/analytical-method-validation/references/ich-q2r2.md +0 -229
- package/skills/analytical-method-validation/references/source-ledger.md +0 -125
- package/skills/analytical-method-validation/references/statistics.md +0 -209
- package/skills/analytical-method-validation/scripts/_catalog.py +0 -499
- package/skills/analytical-method-validation/scripts/_common.py +0 -955
- package/skills/analytical-method-validation/scripts/check_accuracy_precision.py +0 -328
- package/skills/analytical-method-validation/scripts/check_bioanalytical_run.py +0 -293
- package/skills/analytical-method-validation/scripts/check_detection_limits.py +0 -310
- package/skills/analytical-method-validation/scripts/check_response.py +0 -243
- package/skills/analytical-method-validation/scripts/compare_methods.py +0 -215
- package/skills/analytical-method-validation/scripts/plan_validation.py +0 -381
- package/skills/anndata/references/best_practices.md +0 -532
- package/skills/anndata/references/concatenation.md +0 -399
- package/skills/anndata/references/data_structure.md +0 -314
- package/skills/anndata/references/io_operations.md +0 -466
- package/skills/anndata/references/manipulation.md +0 -516
- package/skills/arbor/references/arbor-upstream.md +0 -91
- package/skills/arbor/references/executor-brief.md +0 -68
- package/skills/arbor/references/htr-methodology.md +0 -177
- package/skills/arbor/references/report-template.md +0 -39
- package/skills/arbor/scripts/tree.py +0 -564
- package/skills/arboreto/references/algorithms.md +0 -152
- package/skills/arboreto/references/basic_inference.md +0 -181
- package/skills/arboreto/references/distributed_computing.md +0 -242
- package/skills/arboreto/scripts/basic_grn_inference.py +0 -107
- package/skills/astropy/references/coordinates.md +0 -280
- package/skills/astropy/references/cosmology.md +0 -309
- package/skills/astropy/references/fits.md +0 -398
- package/skills/astropy/references/tables.md +0 -495
- package/skills/astropy/references/time.md +0 -412
- package/skills/astropy/references/units.md +0 -178
- package/skills/astropy/references/wcs_and_other_modules.md +0 -377
- package/skills/autoskill/config.yaml +0 -53
- package/skills/autoskill/references/https-proxy.md +0 -62
- package/skills/autoskill/references/screenpipe-config.yaml +0 -61
- package/skills/autoskill/scripts/autoskill.py +0 -35
- package/skills/autoskill/scripts/backends.py +0 -116
- package/skills/autoskill/scripts/cluster.py +0 -54
- package/skills/autoskill/scripts/doctor.py +0 -108
- package/skills/autoskill/scripts/fetch_window.py +0 -33
- package/skills/autoskill/scripts/match_skills.py +0 -46
- package/skills/autoskill/scripts/promote.py +0 -58
- package/skills/autoskill/scripts/redact.py +0 -40
- package/skills/autoskill/scripts/run.py +0 -194
- package/skills/autoskill/scripts/synthesize.py +0 -72
- package/skills/benchling-integration/references/api_endpoints.md +0 -883
- package/skills/benchling-integration/references/authentication.md +0 -390
- package/skills/benchling-integration/references/core_capabilities.md +0 -355
- package/skills/benchling-integration/references/eventbridge.md +0 -255
- package/skills/benchling-integration/references/sdk_reference.md +0 -772
- package/skills/bids/references/beps.yml +0 -637
- package/skills/bids/references/bids_schema.json +0 -21015
- package/skills/bids/references/bids_specification.md +0 -165
- package/skills/bids/references/conversion_tools.md +0 -475
- package/skills/bids/references/core_workflows.md +0 -552
- package/skills/bids/references/metadata_fields.md +0 -365
- package/skills/bids/scripts/update_schema.py +0 -89
- package/skills/biopython/references/advanced.md +0 -580
- package/skills/biopython/references/alignment.md +0 -377
- package/skills/biopython/references/blast.md +0 -463
- package/skills/biopython/references/databases.md +0 -492
- package/skills/biopython/references/phylogenetics.md +0 -566
- package/skills/biopython/references/sequence_io.md +0 -289
- package/skills/biopython/references/structure.md +0 -564
- package/skills/bioservices/references/identifier_mapping.md +0 -685
- package/skills/bioservices/references/services_reference.md +0 -638
- package/skills/bioservices/references/workflow_patterns.md +0 -813
- package/skills/bioservices/scripts/batch_id_converter.py +0 -347
- package/skills/bioservices/scripts/compound_cross_reference.py +0 -387
- package/skills/bioservices/scripts/pathway_analysis.py +0 -309
- package/skills/bioservices/scripts/protein_analysis_workflow.py +0 -441
- package/skills/bulk-rnaseq/references/counts-and-handoff.md +0 -91
- package/skills/bulk-rnaseq/references/design-and-qc.md +0 -68
- package/skills/bulk-rnaseq/references/upstream-manual.md +0 -128
- package/skills/bulk-rnaseq/references/upstream-nfcore.md +0 -108
- package/skills/bulk-rnaseq/scripts/build_counts_matrix.py +0 -203
- package/skills/bulk-rnaseq/scripts/validate_samplesheet.py +0 -206
- package/skills/cellxgene-census/references/census_schema.md +0 -218
- package/skills/cellxgene-census/references/common_patterns.md +0 -368
- package/skills/cellxgene-census/references/core_workflow_patterns.md +0 -297
- package/skills/cirq/references/building.md +0 -307
- package/skills/cirq/references/experiments.md +0 -572
- package/skills/cirq/references/hardware.md +0 -527
- package/skills/cirq/references/noise.md +0 -514
- package/skills/cirq/references/simulation.md +0 -353
- package/skills/cirq/references/transformation.md +0 -416
- package/skills/citation-management/assets/bibtex_template.bib +0 -264
- package/skills/citation-management/assets/citation_checklist.md +0 -386
- package/skills/citation-management/references/best_practices.md +0 -91
- package/skills/citation-management/references/bibtex_formatting.md +0 -908
- package/skills/citation-management/references/citation_validation.md +0 -835
- package/skills/citation-management/references/core_workflow.md +0 -569
- package/skills/citation-management/references/example_workflows.md +0 -126
- package/skills/citation-management/references/google_scholar_search.md +0 -732
- package/skills/citation-management/references/metadata_extraction.md +0 -870
- package/skills/citation-management/references/pubmed_search.md +0 -839
- package/skills/citation-management/references/script_reference.md +0 -250
- package/skills/citation-management/references/search_strategies.md +0 -110
- package/skills/citation-management/scripts/_common.py +0 -331
- package/skills/citation-management/scripts/doi_to_bibtex.py +0 -204
- package/skills/citation-management/scripts/extract_metadata.py +0 -690
- package/skills/citation-management/scripts/format_bibtex.py +0 -356
- package/skills/citation-management/scripts/search_google_scholar.py +0 -268
- package/skills/citation-management/scripts/search_openalex.py +0 -297
- package/skills/citation-management/scripts/search_pubmed.py +0 -419
- package/skills/citation-management/scripts/validate_citations.py +0 -688
- package/skills/clinical-decision-support/assets/aggregate_cohort_table_template.json +0 -114
- package/skills/clinical-decision-support/assets/aggregate_model_evaluation_template.json +0 -115
- package/skills/clinical-decision-support/assets/artifact_intended_use_template.json +0 -81
- package/skills/clinical-decision-support/assets/decision_logic_traceability_template.json +0 -108
- package/skills/clinical-decision-support/assets/deidentification_checklist_template.json +0 -176
- package/skills/clinical-decision-support/assets/evidence_profile_template.json +0 -139
- package/skills/clinical-decision-support/assets/survival_analysis_plan_template.json +0 -134
- package/skills/clinical-decision-support/references/cohort_evaluation.md +0 -142
- package/skills/clinical-decision-support/references/decision_logic_traceability.md +0 -146
- package/skills/clinical-decision-support/references/evidence_profiles.md +0 -153
- package/skills/clinical-decision-support/references/model_biomarker_evaluation.md +0 -152
- package/skills/clinical-decision-support/references/privacy_and_disclosure.md +0 -144
- package/skills/clinical-decision-support/references/regulatory_and_governance.md +0 -104
- package/skills/clinical-decision-support/references/safety_and_scope.md +0 -103
- package/skills/clinical-decision-support/references/security_validation.md +0 -60
- package/skills/clinical-decision-support/references/sources.md +0 -119
- package/skills/clinical-decision-support/references/study_reporting.md +0 -134
- package/skills/clinical-decision-support/references/survival_analysis.md +0 -156
- package/skills/clinical-decision-support/scripts/_common.py +0 -223
- package/skills/clinical-decision-support/scripts/cohort_table_generator.py +0 -288
- package/skills/clinical-decision-support/scripts/decision_logic_traceability.py +0 -313
- package/skills/clinical-decision-support/scripts/deidentification_checklist.py +0 -260
- package/skills/clinical-decision-support/scripts/evidence_profile_check.py +0 -259
- package/skills/clinical-decision-support/scripts/model_biomarker_evaluation.py +0 -345
- package/skills/clinical-decision-support/scripts/survival_plan_validator.py +0 -294
- package/skills/clinical-decision-support/scripts/validate_cds_artifact.py +0 -269
- package/skills/clinical-reports/assets/adverse_event_aggregate_input_template.csv +0 -1
- package/skills/clinical-reports/assets/case_report_template.json +0 -43
- package/skills/clinical-reports/assets/clinical_trial_csr_template.json +0 -51
- package/skills/clinical-reports/assets/clinical_trial_results_template.json +0 -66
- package/skills/clinical-reports/assets/clinical_trial_safety_aggregate_template.json +0 -49
- package/skills/clinical-reports/assets/consistency_manifest_template.json +0 -15
- package/skills/clinical-reports/assets/deidentification_process_checklist.json +0 -56
- package/skills/clinical-reports/assets/lab_report_template.json +0 -36
- package/skills/clinical-reports/assets/pathology_report_template.json +0 -36
- package/skills/clinical-reports/assets/provenance_manifest_template.json +0 -17
- package/skills/clinical-reports/assets/quality_review_checklist.json +0 -34
- package/skills/clinical-reports/assets/radiology_report_template.json +0 -34
- package/skills/clinical-reports/assets/research_summary_template.json +0 -36
- package/skills/clinical-reports/assets/terminology_manifest_template.json +0 -11
- package/skills/clinical-reports/assets/trial_protocol_reporting_checklist.json +0 -70
- package/skills/clinical-reports/references/case_report_guidelines.md +0 -72
- package/skills/clinical-reports/references/clinical_trial_reporting.md +0 -97
- package/skills/clinical-reports/references/data_presentation.md +0 -92
- package/skills/clinical-reports/references/diagnostic_reports_standards.md +0 -76
- package/skills/clinical-reports/references/medical_terminology.md +0 -84
- package/skills/clinical-reports/references/privacy_and_deidentification.md +0 -84
- package/skills/clinical-reports/references/professional_review.md +0 -78
- package/skills/clinical-reports/references/report_type_routing.md +0 -57
- package/skills/clinical-reports/references/safety_reporting.md +0 -109
- package/skills/clinical-reports/references/sources.md +0 -75
- package/skills/clinical-reports/scripts/_common.py +0 -263
- package/skills/clinical-reports/scripts/check_deidentification.py +0 -298
- package/skills/clinical-reports/scripts/consistency_checker.py +0 -390
- package/skills/clinical-reports/scripts/format_adverse_events.py +0 -455
- package/skills/clinical-reports/scripts/generate_report_template.py +0 -115
- package/skills/clinical-reports/scripts/provenance_validator.py +0 -263
- package/skills/clinical-reports/scripts/terminology_validator.py +0 -277
- package/skills/clinical-reports/scripts/validate_case_report.py +0 -278
- package/skills/clinical-reports/scripts/validate_trial_report.py +0 -534
- package/skills/cobrapy/references/api_quick_reference.md +0 -665
- package/skills/cobrapy/references/workflows.md +0 -600
- package/skills/consciousness-council/references/advanced-configurations.md +0 -96
- package/skills/dask/references/arrays.md +0 -495
- package/skills/dask/references/bags.md +0 -468
- package/skills/dask/references/best-practices.md +0 -277
- package/skills/dask/references/dataframes.md +0 -370
- package/skills/dask/references/futures.md +0 -541
- package/skills/dask/references/schedulers.md +0 -517
- package/skills/database-lookup/references/addgene.md +0 -38
- package/skills/database-lookup/references/alphafold.md +0 -52
- package/skills/database-lookup/references/alphavantage.md +0 -261
- package/skills/database-lookup/references/bea.md +0 -409
- package/skills/database-lookup/references/bindingdb.md +0 -85
- package/skills/database-lookup/references/biogrid.md +0 -110
- package/skills/database-lookup/references/bls.md +0 -235
- package/skills/database-lookup/references/brenda.md +0 -71
- package/skills/database-lookup/references/cbioportal.md +0 -206
- package/skills/database-lookup/references/census.md +0 -251
- package/skills/database-lookup/references/chebi.md +0 -103
- package/skills/database-lookup/references/chembl.md +0 -80
- package/skills/database-lookup/references/clinicaltrials.md +0 -86
- package/skills/database-lookup/references/clinpgx.md +0 -64
- package/skills/database-lookup/references/clinvar.md +0 -91
- package/skills/database-lookup/references/cod.md +0 -121
- package/skills/database-lookup/references/cosmic.md +0 -59
- package/skills/database-lookup/references/dailymed.md +0 -65
- package/skills/database-lookup/references/database_selection_guide.md +0 -166
- package/skills/database-lookup/references/datacommons.md +0 -237
- package/skills/database-lookup/references/dbsnp.md +0 -143
- package/skills/database-lookup/references/disgenet.md +0 -52
- package/skills/database-lookup/references/drugbank.md +0 -54
- package/skills/database-lookup/references/ecb.md +0 -191
- package/skills/database-lookup/references/emdb.md +0 -37
- package/skills/database-lookup/references/ena.md +0 -372
- package/skills/database-lookup/references/encode.md +0 -47
- package/skills/database-lookup/references/ensembl.md +0 -539
- package/skills/database-lookup/references/epa.md +0 -232
- package/skills/database-lookup/references/eurostat.md +0 -237
- package/skills/database-lookup/references/fda.md +0 -64
- package/skills/database-lookup/references/federal-reserve.md +0 -216
- package/skills/database-lookup/references/fred.md +0 -297
- package/skills/database-lookup/references/gene-ontology.md +0 -147
- package/skills/database-lookup/references/geo.md +0 -130
- package/skills/database-lookup/references/gnomad.md +0 -93
- package/skills/database-lookup/references/gtex.md +0 -136
- package/skills/database-lookup/references/gwas-catalog.md +0 -46
- package/skills/database-lookup/references/hca.md +0 -35
- package/skills/database-lookup/references/hpo.md +0 -48
- package/skills/database-lookup/references/human-protein-atlas.md +0 -57
- package/skills/database-lookup/references/interpro.md +0 -120
- package/skills/database-lookup/references/jaspar.md +0 -50
- package/skills/database-lookup/references/kegg.md +0 -78
- package/skills/database-lookup/references/lincs-l1000.md +0 -68
- package/skills/database-lookup/references/materials-project.md +0 -123
- package/skills/database-lookup/references/metabolomics-workbench.md +0 -98
- package/skills/database-lookup/references/monarch.md +0 -46
- package/skills/database-lookup/references/mousemine.md +0 -40
- package/skills/database-lookup/references/nasa-exoplanet-archive.md +0 -112
- package/skills/database-lookup/references/nasa.md +0 -121
- package/skills/database-lookup/references/ncbi-gene.md +0 -64
- package/skills/database-lookup/references/ncbi-protein.md +0 -104
- package/skills/database-lookup/references/ncbi-taxonomy.md +0 -121
- package/skills/database-lookup/references/nist.md +0 -105
- package/skills/database-lookup/references/noaa.md +0 -199
- package/skills/database-lookup/references/omim.md +0 -114
- package/skills/database-lookup/references/opentargets.md +0 -459
- package/skills/database-lookup/references/openweathermap.md +0 -255
- package/skills/database-lookup/references/pdb.md +0 -121
- package/skills/database-lookup/references/pride.md +0 -74
- package/skills/database-lookup/references/pubchem.md +0 -145
- package/skills/database-lookup/references/quickgo.md +0 -45
- package/skills/database-lookup/references/reactome.md +0 -140
- package/skills/database-lookup/references/retrieval-contract.md +0 -123
- package/skills/database-lookup/references/rummageo.md +0 -32
- package/skills/database-lookup/references/sdss.md +0 -130
- package/skills/database-lookup/references/sec-edgar.md +0 -315
- package/skills/database-lookup/references/simbad.md +0 -405
- package/skills/database-lookup/references/sra.md +0 -149
- package/skills/database-lookup/references/string.md +0 -283
- package/skills/database-lookup/references/tcga-gdc.md +0 -58
- package/skills/database-lookup/references/treasury.md +0 -215
- package/skills/database-lookup/references/ucsc-genome.md +0 -135
- package/skills/database-lookup/references/uniprot.md +0 -283
- package/skills/database-lookup/references/usgs.md +0 -260
- package/skills/database-lookup/references/uspto.md +0 -130
- package/skills/database-lookup/references/who.md +0 -283
- package/skills/database-lookup/references/worldbank.md +0 -239
- package/skills/database-lookup/references/zinc.md +0 -202
- package/skills/datamol/references/conformers_module.md +0 -131
- package/skills/datamol/references/core_api.md +0 -136
- package/skills/datamol/references/core_workflows.md +0 -451
- package/skills/datamol/references/descriptors_viz.md +0 -195
- package/skills/datamol/references/fragments_scaffolds.md +0 -174
- package/skills/datamol/references/io_module.md +0 -112
- package/skills/datamol/references/reactions_data.md +0 -218
- package/skills/datamol/references/workflow_patterns.md +0 -104
- package/skills/deepchem/references/api_reference.md +0 -305
- package/skills/deepchem/references/core_capabilities.md +0 -276
- package/skills/deepchem/references/typical_workflows.md +0 -109
- package/skills/deepchem/references/workflows.md +0 -491
- package/skills/deepchem/scripts/graph_neural_network.py +0 -350
- package/skills/deepchem/scripts/predict_solubility.py +0 -223
- package/skills/deepchem/scripts/transfer_learning.py +0 -443
- package/skills/deepspot-m/references/api.md +0 -186
- package/skills/deepspot-m/references/whole_slide.md +0 -174
- package/skills/deeptools/assets/quick_reference.md +0 -65
- package/skills/deeptools/references/core_workflows.md +0 -134
- package/skills/deeptools/references/effective_genome_sizes.md +0 -118
- package/skills/deeptools/references/normalization_methods.md +0 -424
- package/skills/deeptools/references/tools_reference.md +0 -569
- package/skills/deeptools/references/workflows.md +0 -476
- package/skills/deeptools/scripts/validate_files.py +0 -195
- package/skills/deeptools/scripts/workflow_generator.py +0 -520
- package/skills/depmap/references/dependency_analysis.md +0 -178
- package/skills/dhdna-profiler/references/advanced-profiling.md +0 -72
- package/skills/diffdock/assets/batch_template.csv +0 -4
- package/skills/diffdock/assets/custom_inference_config.yaml +0 -94
- package/skills/diffdock/references/confidence_and_limitations.md +0 -182
- package/skills/diffdock/references/parameters_reference.md +0 -173
- package/skills/diffdock/references/workflows_examples.md +0 -401
- package/skills/diffdock/scripts/analyze_results.py +0 -346
- package/skills/diffdock/scripts/prepare_batch_csv.py +0 -257
- package/skills/diffdock/scripts/setup_check.py +0 -283
- package/skills/dnanexus-integration/references/app-development.md +0 -371
- package/skills/dnanexus-integration/references/authentication.md +0 -226
- package/skills/dnanexus-integration/references/configuration.md +0 -444
- package/skills/dnanexus-integration/references/data-operations.md +0 -474
- package/skills/dnanexus-integration/references/job-execution.md +0 -482
- package/skills/dnanexus-integration/references/operations-and-troubleshooting.md +0 -506
- package/skills/dnanexus-integration/references/python-sdk.md +0 -548
- package/skills/dnanexus-integration/references/sources.md +0 -168
- package/skills/dnanexus-integration/references/workflow-languages.md +0 -292
- package/skills/dnanexus-integration/scripts/inspect_dxpy.py +0 -366
- package/skills/dnanexus-integration/scripts/validate_dxapp.py +0 -796
- package/skills/docx/LICENSE.txt +0 -30
- package/skills/docx/scripts/__init__.py +0 -1
- package/skills/docx/scripts/accept_changes.py +0 -135
- package/skills/docx/scripts/comment.py +0 -368
- package/skills/docx/scripts/merge_runs.py +0 -310
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- package/skills/xlsx/scripts/office/schemas/microsoft/wml-cid-2016.xsd +0 -13
- package/skills/xlsx/scripts/office/schemas/microsoft/wml-sdtdatahash-2020.xsd +0 -4
- package/skills/xlsx/scripts/office/schemas/microsoft/wml-symex-2015.xsd +0 -8
- package/skills/xlsx/scripts/office/soffice.py +0 -232
- package/skills/xlsx/scripts/office/validate.py +0 -173
- package/skills/xlsx/scripts/office/validators/__init__.py +0 -15
- package/skills/xlsx/scripts/office/validators/base.py +0 -875
- package/skills/xlsx/scripts/office/validators/docx.py +0 -466
- package/skills/xlsx/scripts/office/validators/pptx.py +0 -441
- package/skills/xlsx/scripts/office/validators/redlining.py +0 -299
- package/skills/xlsx/scripts/recalc.py +0 -308
- package/skills/zarr-python/references/api_reference.md +0 -162
- package/skills/zarr-python/references/chunking_and_compression.md +0 -138
- package/skills/zarr-python/references/integration.md +0 -147
- package/skills/zarr-python/references/performance_and_patterns.md +0 -198
- package/skills/zarr-python/references/storage_backends.md +0 -91
- package/skills/zarr-python/references/v3_migration.md +0 -127
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# Ethical and Confidential Peer Review
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COPE identifies peer review as one of its 10 Core Practices and states that the process should be transparently described and well managed, with policies for conflicts, appeals, and disputes. The target journal’s published process controls the individual assignment.
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## Role boundary
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## Before accepting or starting
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The journal decides whether a disclosed conflict permits review. If unresolved, stop. Do not accept merely to gain access to unpublished work.
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### Capacity and timeliness
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### Journal policy
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Record:
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# Reporting Guidelines and Domain Metadata Standards
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Verified against primary or official sources on **2026-07-23**. The dated evidence record is `assets/source_ledger.csv`; the machine-readable selector catalog is `assets/reporting_guidelines.json`.
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## What reporting guidelines do—and do not do
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- A method for designing or conducting the study
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Checklist completion must never be converted automatically into a quality score. A fully reported study can have serious design problems; an incompletely reported study may be impossible to assess. Record missing information as a reporting gap, then separately assess any design, conduct, analysis, reproducibility, or ethics concern using appropriate evidence and expertise.
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Use the guideline’s current statement together with its explanation and elaboration. Check applicable extensions and the target venue’s instructions. Do not copy checklist wording into a review when a specific, contextual comment is more useful.
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## Selection workflow
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Run:
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```
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The bundled catalog is a dated aid, not a live registry. Consult the [EQUATOR Network](https://www.equator-network.org/) and official guideline site when the study type is unclear or a newer extension may apply.
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## Major current health-research guidelines
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### Randomized trial results — CONSORT 2025
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- Current statement: **CONSORT 2025**, published 14 April 2025
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- Structure: 30 main checklist items and a participant flow diagram
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- Supersedes: CONSORT 2010
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- Use for: reports of randomized trials
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- Review with: explanation and elaboration plus design/intervention extensions
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- Important boundary: the statement explicitly says it is not a quality assessment instrument
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Check registration, protocol and statistical analysis plan consistency, allocation, participant flow, outcomes and harms, effect estimates and uncertainty, protocol changes, data sharing, conflicts, and patient/public involvement where applicable.
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Official sources: [CONSORT–SPIRIT](https://www.consort-spirit.org/) and the [CONSORT 2025 statement](https://www.bmj.com/content/389/bmj-2024-081123).
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### Randomized trial protocols — SPIRIT 2025
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- Current statement: **SPIRIT 2025**, published 28 April 2025
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- Structure: 34 main checklist items and a participant timeline
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- Supersedes: SPIRIT 2013
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- Use for: randomized trial protocols
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Compare the protocol with registration, statistical analysis plan, ethics records, amendments, and any completed-trial report. Explicitly stated non-applicability with rationale is not missing reporting.
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62
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-
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63
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Official sources: [CONSORT–SPIRIT](https://www.consort-spirit.org/) and the [SPIRIT 2025 statement](https://www.bmj.com/content/389/bmj-2024-081477).
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64
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-
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65
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-
### Systematic reviews — PRISMA 2020
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66
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-
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67
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- Current statement: **PRISMA 2020** (named 2020; published 2021)
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68
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- Structure: 27 main items, expanded checklist, abstract checklist, and flow diagrams
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69
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- Use for: completed systematic reviews, primarily reviews of intervention effects
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70
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- Protocols: use PRISMA-P
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71
|
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- Extensions: use the appropriate extension for scoping, diagnostic, individual-participant-data, network, equity, harms, or other specialized reviews
|
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72
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-
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73
|
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PRISMA explicitly does not assess review conduct or methodological quality. Use appropriate methods and risk-of-bias tools separately.
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74
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-
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75
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-
Official sources: [PRISMA 2020 resources](https://www.prisma-statement.org/prisma-2020) and the [primary statement](https://www.bmj.com/content/372/bmj.n71).
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76
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77
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-
### Observational studies — STROBE
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78
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-
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79
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- Current base statement: **STROBE 2007**
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80
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- Structure: 22 main items with cohort, case-control, cross-sectional, and combined checklists
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81
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- Use for: reports of observational epidemiologic studies
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82
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- Extensions: examples include RECORD for routinely collected health data, STREGA for genetic association studies, STROBE-MR, and domain-specific extensions
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83
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-
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84
|
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STROBE helps identify whether selection, measurement, bias, confounding, missing data, sensitivity analyses, and generalizability are reported. It does not establish that those methods were adequate.
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85
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-
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86
|
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Official source: [STROBE](https://www.strobe-statement.org/).
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87
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-
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88
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-
### Diagnostic accuracy — STARD 2015
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89
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-
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90
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- Current base statement: **STARD 2015**
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91
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- Structure: 30 main items and a flow diagram
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92
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- Use for: studies estimating diagnostic accuracy against a reference standard
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93
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94
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Separately assess risk of bias and applicability with a suitable tool such as the current QUADAS family when relevant. STARD’s official implementation guidance explicitly says not to use the reporting checklist as a design-quality tool.
|
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95
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-
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|
96
|
-
Official source: [STARD 2015](https://www.equator-network.org/reporting-guidelines/stard/).
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97
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|
98
|
-
### AI-centered diagnostic accuracy — STARD-AI
|
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99
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-
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|
100
|
-
- Current statement: **STARD-AI 2025**
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|
101
|
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- Published: 15 September 2025; an author correction was published 13 July 2026
|
|
102
|
-
- Structure: 40 items, including 18 new or modified items relative to STARD 2015
|
|
103
|
-
- Use for: AI-centered diagnostic accuracy studies, including suitable diagnostic classification tasks
|
|
104
|
-
|
|
105
|
-
Check dataset practices, index-test specification, evaluation, algorithmic bias and fairness, applicability, and generalizability. If the primary aim is development or evaluation of a multivariable prediction model, use TRIPOD+AI instead.
|
|
106
|
-
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107
|
-
Official source: [STARD-AI](https://www.nature.com/articles/s41591-025-03953-8).
|
|
108
|
-
|
|
109
|
-
### Clinical prediction models — TRIPOD+AI
|
|
110
|
-
|
|
111
|
-
- Current statement: **TRIPOD+AI 2024**
|
|
112
|
-
- Structure: 27 main items plus a 13-item abstract checklist
|
|
113
|
-
- Replaces: TRIPOD 2015
|
|
114
|
-
- Use for: development, evaluation, or updating of diagnostic or prognostic prediction models using regression or machine-learning methods
|
|
115
|
-
|
|
116
|
-
Do not select it solely because software called “AI” appears in a paper. Select it when the study’s primary object is a prediction model. Relevant extensions include TRIPOD-Cluster, TRIPOD-SRMA, and TRIPOD-LLM.
|
|
117
|
-
|
|
118
|
-
Official sources: [TRIPOD](https://www.tripod-statement.org/) and the [TRIPOD+AI statement](https://www.bmj.com/content/385/bmj-2023-078378).
|
|
119
|
-
|
|
120
|
-
### Case reports — CARE
|
|
121
|
-
|
|
122
|
-
- Current base checklist: **CARE 2013**
|
|
123
|
-
- Explanation and elaboration/manual: 2017
|
|
124
|
-
- Structure: 13 main items
|
|
125
|
-
- Use for: clinical case reports
|
|
126
|
-
|
|
127
|
-
Check timeline, diagnostic reasoning, interventions, outcomes, adverse events, patient perspective where available, informed consent, privacy, and venue requirements.
|
|
128
|
-
|
|
129
|
-
Official source: [CARE checklist](https://www.care-statement.org/checklist).
|
|
130
|
-
|
|
131
|
-
### In vivo animal research — ARRIVE 2.0
|
|
132
|
-
|
|
133
|
-
- Current statement: **ARRIVE 2.0**, published July 2020
|
|
134
|
-
- Structure: Essential 10 plus 11 Recommended Set items
|
|
135
|
-
- Use for: research involving live animals across bioscience disciplines
|
|
136
|
-
|
|
137
|
-
The Essential 10 are a minimum reporting set, not a ranking. Review study design, sample size, inclusion/exclusion, randomization, blinding, outcome measures, statistics, animal details, procedures, and results; also assess ethics, welfare, humane endpoints, adverse events, protocol registration, data access, and interests.
|
|
138
|
-
|
|
139
|
-
Official source: [ARRIVE 2.0](https://arriveguidelines.org/arrive-guidelines).
|
|
140
|
-
|
|
141
|
-
### Quality improvement — SQUIRE 2.0
|
|
142
|
-
|
|
143
|
-
- Current statement: **SQUIRE 2.0**, published 2015
|
|
144
|
-
- Structure: 18 main items
|
|
145
|
-
- Use for: system-level work intended to improve healthcare quality, safety, value, or equity where methods seek to relate outcomes to the intervention
|
|
146
|
-
|
|
147
|
-
SQUIRE states that every item should be considered, but not every element belongs in every manuscript. Attend to local context, rationale, intervention evolution, measures, analysis, ethics, unintended consequences, and sustainability.
|
|
148
|
-
|
|
149
|
-
Official source: [SQUIRE 2.0](https://www.squire-statement.org/index.cfm?fuseaction=page.viewPage&pageID=471&nodeID=1).
|
|
150
|
-
|
|
151
|
-
### Health economic evaluations — CHEERS 2022
|
|
152
|
-
|
|
153
|
-
- Current statement: **CHEERS 2022**
|
|
154
|
-
- Structure: 28 main items
|
|
155
|
-
- Replaces: CHEERS 2013
|
|
156
|
-
- Use for: economic evaluations of health interventions
|
|
157
|
-
|
|
158
|
-
Assess perspective, comparators, time horizon, discounting, outcome and cost measurement, model assumptions, heterogeneity, distributional effects where applicable, uncertainty, engagement, funding, and conflicts. Use a separate critical-appraisal framework for methodological quality.
|
|
159
|
-
|
|
160
|
-
Official source: [ISPOR CHEERS](https://www.ispor.org/heor-resources/good-practices/cheers).
|
|
161
|
-
|
|
162
|
-
### Qualitative research — SRQR and COREQ
|
|
163
|
-
|
|
164
|
-
- **SRQR**: broad qualitative research reporting standard
|
|
165
|
-
- **COREQ**: 32-item checklist specifically for interviews and focus groups
|
|
166
|
-
|
|
167
|
-
Select by methods, not by the presence of quotations. Review researcher reflexivity, sampling, context, data collection, analytic process, credibility, participant voice, ethics, and limitations without imposing one epistemology on all qualitative traditions.
|
|
168
|
-
|
|
169
|
-
Official registry records: [SRQR](https://www.equator-network.org/reporting-guidelines/srqr) and [COREQ](https://www.equator-network.org/reporting-guidelines/coreq/).
|
|
170
|
-
|
|
171
|
-
## AI extensions and overlap
|
|
172
|
-
|
|
173
|
-
Use the guideline that matches the study’s primary design and claim:
|
|
174
|
-
|
|
175
|
-
- Randomized trial of an AI intervention: CONSORT 2025 plus current CONSORT-AI guidance
|
|
176
|
-
- Protocol for such a trial: SPIRIT 2025 plus current SPIRIT-AI guidance
|
|
177
|
-
- AI diagnostic accuracy: STARD-AI
|
|
178
|
-
- Prediction model development or performance evaluation: TRIPOD+AI
|
|
179
|
-
- Biomedical large-language-model prediction or evaluation: check TRIPOD-LLM and design-specific guidance
|
|
180
|
-
- Medical imaging AI: consider current modality guidance in addition to the design-specific base
|
|
181
|
-
|
|
182
|
-
Multiple guidelines can apply, but do not create redundant demands. State which base and extension address each concern.
|
|
183
|
-
|
|
184
|
-
## Domain metadata standards: verified legacy status
|
|
185
|
-
|
|
186
|
-
These standards describe minimum experiment or repository metadata. They complement, rather than replace, study-design reporting and methodological appraisal.
|
|
187
|
-
|
|
188
|
-
### MIAME and MINSEQE
|
|
189
|
-
|
|
190
|
-
**Retain with qualification.** NCBI GEO’s page was last modified 8 July 2026 and still states that GEO submission procedures implement:
|
|
191
|
-
|
|
192
|
-
- MIAME for microarray experiments
|
|
193
|
-
- MINSEQE for next-generation/high-throughput sequencing experiments
|
|
194
|
-
|
|
195
|
-
ArrayExpress/Annotare also continues to reference these standards. Verify the current repository’s fields, file formats, raw/processed data expectations, and accession requirements; do not rely on an old static project page alone.
|
|
196
|
-
|
|
197
|
-
Official implementation source: [GEO and MIAME/MINSEQE](https://www.ncbi.nlm.nih.gov/geo/info/MIAME.html).
|
|
198
|
-
|
|
199
|
-
### MIAPE
|
|
200
|
-
|
|
201
|
-
**Retain as a modular current-qualified standard.** The HUPO Proteomics Standards Initiative lists released components with separate versions, including mass spectrometry, mass-spectrometry informatics, quantification, gel electrophoresis, gel informatics, chromatography, and capillary electrophoresis.
|
|
202
|
-
|
|
203
|
-
Select only components relevant to the actual workflow and verify current repository expectations. Do not present “MIAPE” as one unversioned universal checklist.
|
|
204
|
-
|
|
205
|
-
Official source: [HUPO-PSI MIAPE](https://www.psidev.info/miape).
|
|
206
|
-
|
|
207
|
-
### MIFlowCyt
|
|
208
|
-
|
|
209
|
-
**Retain with qualification.** ISAC continues to identify MIFlowCyt 1.0 as an ISAC recommendation for experiment overview, samples, instrumentation, and data analysis. Also check current FCS, gating, panel, controls, and FlowRepository requirements.
|
|
210
|
-
|
|
211
|
-
Official source: [ISAC MIFlowCyt](https://isac-net.org/miflowcyt-2/).
|
|
212
|
-
|
|
213
|
-
### MIAPPE
|
|
214
|
-
|
|
215
|
-
**Use MIAPPE 1.2**, released October 2024, for plant phenotyping metadata. It remains compatible with 1.1; version 2.0 was still in early development on the verification date.
|
|
216
|
-
|
|
217
|
-
Official source: [MIAPPE releases](https://www.miappe.org/releases).
|
|
218
|
-
|
|
219
|
-
### MIGS and MIMS
|
|
220
|
-
|
|
221
|
-
**Do not present standalone MIGS/MIMS as the current umbrella.** The Genomic Standards Consortium now organizes these legacy checklists within **MIxS** (Minimum Information about any Sequence), alongside newer checklists and environmental packages. Select the current MIxS release and applicable checklist/package.
|
|
222
|
-
|
|
223
|
-
Official source: [GSC standards](https://www.gensc.org/pages/standards-intro.html).
|
|
224
|
-
|
|
225
|
-
## Other study types
|
|
226
|
-
|
|
227
|
-
The EQUATOR database contains hundreds of guidelines. Common additional choices include:
|
|
228
|
-
|
|
229
|
-
- Protocols: design-specific protocol guidance
|
|
230
|
-
- Routinely collected health data: RECORD
|
|
231
|
-
- Clinical practice guidelines: RIGHT and AGREE reporting guidance
|
|
232
|
-
- Surveys: design-appropriate survey reporting guidance
|
|
233
|
-
- Implementation studies: current implementation-reporting guidance
|
|
234
|
-
- Mixed methods: current mixed-methods guidance
|
|
235
|
-
- Laboratory and omics studies: study-design reporting plus current repository metadata standards
|
|
236
|
-
|
|
237
|
-
If no suitable guideline exists, say so. Do not force the nearest checklist or invent one.
|
|
238
|
-
|
|
239
|
-
## Coverage language for reviews
|
|
240
|
-
|
|
241
|
-
Use:
|
|
242
|
-
|
|
243
|
-
> “Item 12 is not reported clearly enough to determine the analysis population. Please identify the included participants and reconcile this denominator with Figure 1.”
|
|
244
|
-
|
|
245
|
-
Avoid:
|
|
246
|
-
|
|
247
|
-
> “The manuscript scores 18/30 on CONSORT and is therefore low quality.”
|
|
248
|
-
|
|
249
|
-
Report counts or item identifiers only as navigation aids. The local selector deliberately emits no percentage or merit score.
|
|
@@ -1,75 +0,0 @@
|
|
|
1
|
-
# Security Validation Record
|
|
2
|
-
|
|
3
|
-
Validation date: **2026-07-23** (local project date).
|
|
4
|
-
|
|
5
|
-
## Baseline
|
|
6
|
-
|
|
7
|
-
The repository `SECURITY.md` entry recorded **10 findings** with maximum severity **CRITICAL**:
|
|
8
|
-
|
|
9
|
-
- Cross-file environment-variable and network exfiltration
|
|
10
|
-
- A multi-file collection/transmission chain
|
|
11
|
-
- Environment harvesting in both schematic scripts
|
|
12
|
-
- API-key transmission to an external model service
|
|
13
|
-
- Full environment propagation to a subprocess
|
|
14
|
-
- Repeated costly model/image operations
|
|
15
|
-
- Mandatory external schematic/cross-skill behavior
|
|
16
|
-
|
|
17
|
-
The affected files were:
|
|
18
|
-
|
|
19
|
-
- Deleted: scripts/generate_schematic.py
|
|
20
|
-
- Deleted: scripts/generate_schematic_ai.py
|
|
21
|
-
- The former `SKILL.md`
|
|
22
|
-
|
|
23
|
-
## Remediation
|
|
24
|
-
|
|
25
|
-
- Deleted both external schematic scripts.
|
|
26
|
-
- Removed credentials, environment access, `.env` loading, subprocess chaining, network requests, model calls, image generation, mandatory figures, and cross-skill calls.
|
|
27
|
-
- Replaced them with bounded deterministic local JSON/CSV/Markdown validators and generators.
|
|
28
|
-
- Added strict schemas, duplicate-key/header detection, size/row/cell limits, symlink rejection, private atomic output, and no implicit overwrite.
|
|
29
|
-
- Added report minimization: IDs, counts, rule codes, and line numbers instead of manuscript/review prose.
|
|
30
|
-
- Added AST tests that reject network libraries, executable serialization, dynamic code execution, and environment credential access.
|
|
31
|
-
- Added confidentiality, no-reuse, authorization, conflict, competence, AI-policy, disclosure, and deletion/retention gates.
|
|
32
|
-
|
|
33
|
-
## Validation results
|
|
34
|
-
|
|
35
|
-
- Agent Skills reference validator: **PASS**
|
|
36
|
-
- Dependency-free CLI help checks: **PASS**
|
|
37
|
-
- Synthetic standard-library tests: **26 passed**
|
|
38
|
-
- Explicit AST parse with bytecode disabled: **8 scripts parsed**
|
|
39
|
-
- Bytecode artifacts: **0**
|
|
40
|
-
- IDE lints: **0**
|
|
41
|
-
- Documented local-path link test: **PASS**
|
|
42
|
-
- Markdown link check: **PASS** (access-controlled HTTP 403 treated as reachable)
|
|
43
|
-
- Direct behavioral security scan: **SAFE, 0 findings**
|
|
44
|
-
- Pull-request gate with `--fail-on HIGH`: **PASS**
|
|
45
|
-
- CRITICAL: 0
|
|
46
|
-
- HIGH: 0
|
|
47
|
-
- LOW: 3
|
|
48
|
-
|
|
49
|
-
## Residual LOW findings
|
|
50
|
-
|
|
51
|
-
The final LLM-assisted pull-request scan reported:
|
|
52
|
-
|
|
53
|
-
1. **Missing `allowed-tools` declaration** — informational. This field is optional under the Agent Skills specification. The compatibility and body explicitly constrain bundled tools to local standard-library processing with no network, model, image, credential, or environment access.
|
|
54
|
-
2. **Broad description** — accepted as a scoped capability description. The mandatory authorization and venue-policy gate applies before confidential content is read, and the body limits all functions to peer-review assessment.
|
|
55
|
-
3. **Bounded CSV/JSON processing** — defensive observation with “no action required” in the scanner output. Inputs are already limited to 4 MiB, 5,000 CSV rows, 12,000 characters per cell, and finite list sizes; tests cover oversize rejection.
|
|
56
|
-
|
|
57
|
-
None of the LOW findings permits data transmission or credential access. No CRITICAL or HIGH issue remains.
|
|
58
|
-
|
|
59
|
-
## Reproduction
|
|
60
|
-
|
|
61
|
-
```bash
|
|
62
|
-
PYTHONDONTWRITEBYTECODE=1 python3 -m unittest discover \
|
|
63
|
-
-s tests/peer-review -p "test_*.py" -v
|
|
64
|
-
|
|
65
|
-
uv run skills-ref validate skills/peer-review
|
|
66
|
-
|
|
67
|
-
uv run skill-scanner scan skills/peer-review --use-behavioral
|
|
68
|
-
|
|
69
|
-
uv run python scan_pr_skills.py \
|
|
70
|
-
--fail-on HIGH \
|
|
71
|
-
--output /tmp/peer-review-pr-scan.md \
|
|
72
|
-
skills/peer-review
|
|
73
|
-
```
|
|
74
|
-
|
|
75
|
-
The repository-level `SECURITY.md` was intentionally not edited in this scoped refresh; its generated snapshot will update through the repository’s normal scan process.
|