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+        Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>.
+        To find a statistically significant separation point for the QuantiFERON Gold
+        In-Tube (QFT) interferon gamma release assay that could define an optimal
+        \u201cretesting zone\u201d for use in serially tested low-risk populations
+        who have test \u201creversions\u201d from initially positive to subsequently
+        negative results.<jats:italic>Method<\/jats:italic>. Using receiver operating
+        characteristic analysis (ROC) to analyze retrospective data collected from
+        3 major hospitals, we searched for predictors of reversion until statistically
+        significant separation points were revealed. A confirmatory regression analysis
+        was performed on an additional sample.<jats:italic>Results<\/jats:italic>.
+        In 575 initially positive US healthcare workers (HCWs), 300 (52.2%) had reversions,
+        while 275 (47.8%) had two sequential positive tests. The most statistically
+        significant (Kappa\u2009=\u20090.48, chi-square\u2009=\u2009131.0,<mml:math
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+        separation point identified by the ROC for predicting reversion was the tuberculosis
+        antigen minus-nil (TBag-nil) value at 1.11 International Units per milliliter
+        (IU\/mL). The second separation point was found at TBag-nil at 0.72\u2009IU\/mL
+        (Kappa\u2009=\u20090.16, chi-square\u2009=\u20098.2,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"
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+        The model was validated by the regression analysis of 287\u2009HCWs.<jats:italic>Conclusion<\/jats:italic>.
+        Reversion likelihood increases as the TBag-nil approaches the manufacturer''s
+        cut-point of 0.35\u2009IU\/mL. The most statistically significant separation
+        point between those who test repeatedly positive and those who revert is 1.11\u2009IU\/mL.
+        Clinicians should retest low-risk individuals with initial QFT results\u2009&lt;\u20091.11\u2009IU\/mL.<\/jats:p>","DOI":"10.1155\/2012\/291294","type":"journal-article","created":{"date-parts":[[2012,12,30]],"date-time":"2012-12-30T21:05:01Z","timestamp":1356901501000},"page":"1-7","source":"Crossref","is-referenced-by-count":30,"title":["Delineating
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+        it becomes evident that this change in the dynamics is related to changes
+        of the solvent properties. These changes are accompanied by an increasing
+        heterogeneity in the dynamics of the tracer particles. The findings are in
+        agreement with an interpretation that domains of correlated dynamics in the
+        supercooled glass formers grow in size with decreasing temperature.","descriptionType":"Abstract"},{"description":"Published
+        by University of Hamburg, Hamburg","descriptionType":"Other"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"http://bib-pubdb1.desy.de/record/166827","contentUrl":null,"metadataVersion":1,"schemaVersion":null,"source":null,"isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0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