@synsci/cli-darwin-x64-baseline 1.1.76 → 1.1.78

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (830) hide show
  1. package/bin/skills/adaptyv/SKILL.md +114 -0
  2. package/bin/skills/adaptyv/reference/api_reference.md +308 -0
  3. package/bin/skills/adaptyv/reference/examples.md +913 -0
  4. package/bin/skills/adaptyv/reference/experiments.md +360 -0
  5. package/bin/skills/adaptyv/reference/protein_optimization.md +637 -0
  6. package/bin/skills/aeon/SKILL.md +374 -0
  7. package/bin/skills/aeon/references/anomaly_detection.md +154 -0
  8. package/bin/skills/aeon/references/classification.md +144 -0
  9. package/bin/skills/aeon/references/clustering.md +123 -0
  10. package/bin/skills/aeon/references/datasets_benchmarking.md +387 -0
  11. package/bin/skills/aeon/references/distances.md +256 -0
  12. package/bin/skills/aeon/references/forecasting.md +140 -0
  13. package/bin/skills/aeon/references/networks.md +289 -0
  14. package/bin/skills/aeon/references/regression.md +118 -0
  15. package/bin/skills/aeon/references/segmentation.md +163 -0
  16. package/bin/skills/aeon/references/similarity_search.md +187 -0
  17. package/bin/skills/aeon/references/transformations.md +246 -0
  18. package/bin/skills/alphafold-database/SKILL.md +513 -0
  19. package/bin/skills/alphafold-database/references/api_reference.md +423 -0
  20. package/bin/skills/anndata/SKILL.md +400 -0
  21. package/bin/skills/anndata/references/best_practices.md +525 -0
  22. package/bin/skills/anndata/references/concatenation.md +396 -0
  23. package/bin/skills/anndata/references/data_structure.md +314 -0
  24. package/bin/skills/anndata/references/io_operations.md +404 -0
  25. package/bin/skills/anndata/references/manipulation.md +516 -0
  26. package/bin/skills/arboreto/SKILL.md +243 -0
  27. package/bin/skills/arboreto/references/algorithms.md +138 -0
  28. package/bin/skills/arboreto/references/basic_inference.md +151 -0
  29. package/bin/skills/arboreto/references/distributed_computing.md +242 -0
  30. package/bin/skills/arboreto/scripts/basic_grn_inference.py +97 -0
  31. package/bin/skills/astropy/SKILL.md +331 -0
  32. package/bin/skills/astropy/references/coordinates.md +273 -0
  33. package/bin/skills/astropy/references/cosmology.md +307 -0
  34. package/bin/skills/astropy/references/fits.md +396 -0
  35. package/bin/skills/astropy/references/tables.md +489 -0
  36. package/bin/skills/astropy/references/time.md +404 -0
  37. package/bin/skills/astropy/references/units.md +178 -0
  38. package/bin/skills/astropy/references/wcs_and_other_modules.md +373 -0
  39. package/bin/skills/benchling-integration/SKILL.md +480 -0
  40. package/bin/skills/benchling-integration/references/api_endpoints.md +883 -0
  41. package/bin/skills/benchling-integration/references/authentication.md +379 -0
  42. package/bin/skills/benchling-integration/references/sdk_reference.md +774 -0
  43. package/bin/skills/biopython/SKILL.md +443 -0
  44. package/bin/skills/biopython/references/advanced.md +577 -0
  45. package/bin/skills/biopython/references/alignment.md +362 -0
  46. package/bin/skills/biopython/references/blast.md +455 -0
  47. package/bin/skills/biopython/references/databases.md +484 -0
  48. package/bin/skills/biopython/references/phylogenetics.md +566 -0
  49. package/bin/skills/biopython/references/sequence_io.md +285 -0
  50. package/bin/skills/biopython/references/structure.md +564 -0
  51. package/bin/skills/biorxiv-database/SKILL.md +483 -0
  52. package/bin/skills/biorxiv-database/references/api_reference.md +280 -0
  53. package/bin/skills/biorxiv-database/scripts/biorxiv_search.py +445 -0
  54. package/bin/skills/bioservices/SKILL.md +361 -0
  55. package/bin/skills/bioservices/references/identifier_mapping.md +685 -0
  56. package/bin/skills/bioservices/references/services_reference.md +636 -0
  57. package/bin/skills/bioservices/references/workflow_patterns.md +811 -0
  58. package/bin/skills/bioservices/scripts/batch_id_converter.py +347 -0
  59. package/bin/skills/bioservices/scripts/compound_cross_reference.py +378 -0
  60. package/bin/skills/bioservices/scripts/pathway_analysis.py +309 -0
  61. package/bin/skills/bioservices/scripts/protein_analysis_workflow.py +408 -0
  62. package/bin/skills/brenda-database/SKILL.md +719 -0
  63. package/bin/skills/brenda-database/references/api_reference.md +537 -0
  64. package/bin/skills/brenda-database/scripts/brenda_queries.py +844 -0
  65. package/bin/skills/brenda-database/scripts/brenda_visualization.py +772 -0
  66. package/bin/skills/brenda-database/scripts/enzyme_pathway_builder.py +1053 -0
  67. package/bin/skills/cellxgene-census/SKILL.md +511 -0
  68. package/bin/skills/cellxgene-census/references/census_schema.md +182 -0
  69. package/bin/skills/cellxgene-census/references/common_patterns.md +351 -0
  70. package/bin/skills/chembl-database/SKILL.md +389 -0
  71. package/bin/skills/chembl-database/references/api_reference.md +272 -0
  72. package/bin/skills/chembl-database/scripts/example_queries.py +278 -0
  73. package/bin/skills/cirq/SKILL.md +346 -0
  74. package/bin/skills/cirq/references/building.md +307 -0
  75. package/bin/skills/cirq/references/experiments.md +572 -0
  76. package/bin/skills/cirq/references/hardware.md +515 -0
  77. package/bin/skills/cirq/references/noise.md +515 -0
  78. package/bin/skills/cirq/references/simulation.md +350 -0
  79. package/bin/skills/cirq/references/transformation.md +416 -0
  80. package/bin/skills/clinicaltrials-database/SKILL.md +507 -0
  81. package/bin/skills/clinicaltrials-database/references/api_reference.md +358 -0
  82. package/bin/skills/clinicaltrials-database/scripts/query_clinicaltrials.py +215 -0
  83. package/bin/skills/clinpgx-database/SKILL.md +638 -0
  84. package/bin/skills/clinpgx-database/references/api_reference.md +757 -0
  85. package/bin/skills/clinpgx-database/scripts/query_clinpgx.py +518 -0
  86. package/bin/skills/clinvar-database/SKILL.md +362 -0
  87. package/bin/skills/clinvar-database/references/api_reference.md +227 -0
  88. package/bin/skills/clinvar-database/references/clinical_significance.md +218 -0
  89. package/bin/skills/clinvar-database/references/data_formats.md +358 -0
  90. package/bin/skills/cobrapy/SKILL.md +463 -0
  91. package/bin/skills/cobrapy/references/api_quick_reference.md +655 -0
  92. package/bin/skills/cobrapy/references/workflows.md +593 -0
  93. package/bin/skills/cosmic-database/SKILL.md +336 -0
  94. package/bin/skills/cosmic-database/references/cosmic_data_reference.md +220 -0
  95. package/bin/skills/cosmic-database/scripts/download_cosmic.py +231 -0
  96. package/bin/skills/dask/SKILL.md +456 -0
  97. package/bin/skills/dask/references/arrays.md +497 -0
  98. package/bin/skills/dask/references/bags.md +468 -0
  99. package/bin/skills/dask/references/best-practices.md +277 -0
  100. package/bin/skills/dask/references/dataframes.md +368 -0
  101. package/bin/skills/dask/references/futures.md +541 -0
  102. package/bin/skills/dask/references/schedulers.md +504 -0
  103. package/bin/skills/datacommons-client/SKILL.md +255 -0
  104. package/bin/skills/datacommons-client/references/getting_started.md +417 -0
  105. package/bin/skills/datacommons-client/references/node.md +250 -0
  106. package/bin/skills/datacommons-client/references/observation.md +185 -0
  107. package/bin/skills/datacommons-client/references/resolve.md +246 -0
  108. package/bin/skills/datamol/SKILL.md +706 -0
  109. package/bin/skills/datamol/references/conformers_module.md +131 -0
  110. package/bin/skills/datamol/references/core_api.md +130 -0
  111. package/bin/skills/datamol/references/descriptors_viz.md +195 -0
  112. package/bin/skills/datamol/references/fragments_scaffolds.md +174 -0
  113. package/bin/skills/datamol/references/io_module.md +109 -0
  114. package/bin/skills/datamol/references/reactions_data.md +218 -0
  115. package/bin/skills/deepchem/SKILL.md +597 -0
  116. package/bin/skills/deepchem/references/api_reference.md +303 -0
  117. package/bin/skills/deepchem/references/workflows.md +491 -0
  118. package/bin/skills/deepchem/scripts/graph_neural_network.py +338 -0
  119. package/bin/skills/deepchem/scripts/predict_solubility.py +224 -0
  120. package/bin/skills/deepchem/scripts/transfer_learning.py +375 -0
  121. package/bin/skills/deeptools/SKILL.md +531 -0
  122. package/bin/skills/deeptools/assets/quick_reference.md +58 -0
  123. package/bin/skills/deeptools/references/effective_genome_sizes.md +116 -0
  124. package/bin/skills/deeptools/references/normalization_methods.md +410 -0
  125. package/bin/skills/deeptools/references/tools_reference.md +533 -0
  126. package/bin/skills/deeptools/references/workflows.md +474 -0
  127. package/bin/skills/deeptools/scripts/validate_files.py +195 -0
  128. package/bin/skills/deeptools/scripts/workflow_generator.py +454 -0
  129. package/bin/skills/denario/SKILL.md +215 -0
  130. package/bin/skills/denario/references/examples.md +494 -0
  131. package/bin/skills/denario/references/installation.md +213 -0
  132. package/bin/skills/denario/references/llm_configuration.md +265 -0
  133. package/bin/skills/denario/references/research_pipeline.md +471 -0
  134. package/bin/skills/diffdock/SKILL.md +483 -0
  135. package/bin/skills/diffdock/assets/batch_template.csv +4 -0
  136. package/bin/skills/diffdock/assets/custom_inference_config.yaml +90 -0
  137. package/bin/skills/diffdock/references/confidence_and_limitations.md +182 -0
  138. package/bin/skills/diffdock/references/parameters_reference.md +163 -0
  139. package/bin/skills/diffdock/references/workflows_examples.md +392 -0
  140. package/bin/skills/diffdock/scripts/analyze_results.py +334 -0
  141. package/bin/skills/diffdock/scripts/prepare_batch_csv.py +254 -0
  142. package/bin/skills/diffdock/scripts/setup_check.py +278 -0
  143. package/bin/skills/dnanexus-integration/SKILL.md +383 -0
  144. package/bin/skills/dnanexus-integration/references/app-development.md +247 -0
  145. package/bin/skills/dnanexus-integration/references/configuration.md +646 -0
  146. package/bin/skills/dnanexus-integration/references/data-operations.md +400 -0
  147. package/bin/skills/dnanexus-integration/references/job-execution.md +412 -0
  148. package/bin/skills/dnanexus-integration/references/python-sdk.md +523 -0
  149. package/bin/skills/document-skills/docx/LICENSE.txt +30 -0
  150. package/bin/skills/document-skills/docx/SKILL.md +233 -0
  151. package/bin/skills/document-skills/docx/docx-js.md +350 -0
  152. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-chart.xsd +1499 -0
  153. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-chartDrawing.xsd +146 -0
  154. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-diagram.xsd +1085 -0
  155. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-lockedCanvas.xsd +11 -0
  156. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-main.xsd +3081 -0
  157. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-picture.xsd +23 -0
  158. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-spreadsheetDrawing.xsd +185 -0
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  160. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/pml.xsd +1676 -0
  161. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/shared-additionalCharacteristics.xsd +28 -0
  162. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/shared-bibliography.xsd +144 -0
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  193. package/bin/skills/document-skills/docx/ooxml/scripts/validate.py +69 -0
  194. package/bin/skills/document-skills/docx/ooxml/scripts/validation/__init__.py +15 -0
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@@ -0,0 +1,433 @@
1
+ # Hardware Backends and Execution
2
+
3
+ Qiskit is backend-agnostic and supports execution on simulators and real quantum hardware from multiple providers.
4
+
5
+ ## Backend Types
6
+
7
+ ### Local Simulators
8
+ - Run on your machine
9
+ - No account required
10
+ - Perfect for development and testing
11
+
12
+ ### Cloud-Based Hardware
13
+ - IBM Quantum (100+ qubit systems)
14
+ - IonQ (trapped ion)
15
+ - Amazon Braket (Rigetti, IonQ, Oxford Quantum Circuits)
16
+ - Other providers via plugins
17
+
18
+ ## IBM Quantum Backends
19
+
20
+ ### Connecting to IBM Quantum
21
+
22
+ ```python
23
+ from qiskit_ibm_runtime import QiskitRuntimeService
24
+
25
+ # First time: save credentials
26
+ QiskitRuntimeService.save_account(
27
+ channel="ibm_quantum",
28
+ token="YOUR_IBM_QUANTUM_TOKEN"
29
+ )
30
+
31
+ # Subsequent sessions: load credentials
32
+ service = QiskitRuntimeService()
33
+ ```
34
+
35
+ ### Listing Available Backends
36
+
37
+ ```python
38
+ # List all available backends
39
+ backends = service.backends()
40
+ for backend in backends:
41
+ print(f"{backend.name}: {backend.num_qubits} qubits")
42
+
43
+ # Filter by minimum qubits
44
+ backends_127q = service.backends(min_num_qubits=127)
45
+
46
+ # Get specific backend
47
+ backend = service.backend("ibm_brisbane")
48
+ backend = service.least_busy() # Get least busy backend
49
+ ```
50
+
51
+ ### Backend Properties
52
+
53
+ ```python
54
+ backend = service.backend("ibm_brisbane")
55
+
56
+ # Basic info
57
+ print(f"Name: {backend.name}")
58
+ print(f"Qubits: {backend.num_qubits}")
59
+ print(f"Version: {backend.version}")
60
+ print(f"Status: {backend.status()}")
61
+
62
+ # Coupling map (qubit connectivity)
63
+ print(backend.coupling_map)
64
+
65
+ # Basis gates
66
+ print(backend.configuration().basis_gates)
67
+
68
+ # Qubit properties
69
+ print(backend.qubit_properties(0)) # Properties of qubit 0
70
+ ```
71
+
72
+ ### Checking Backend Status
73
+
74
+ ```python
75
+ status = backend.status()
76
+ print(f"Operational: {status.operational}")
77
+ print(f"Pending jobs: {status.pending_jobs}")
78
+ print(f"Status message: {status.status_msg}")
79
+ ```
80
+
81
+ ## Running on IBM Quantum Hardware
82
+
83
+ ### Using Runtime Primitives
84
+
85
+ ```python
86
+ from qiskit import QuantumCircuit, transpile
87
+ from qiskit_ibm_runtime import QiskitRuntimeService, SamplerV2 as Sampler
88
+
89
+ service = QiskitRuntimeService()
90
+ backend = service.backend("ibm_brisbane")
91
+
92
+ # Create and transpile circuit
93
+ qc = QuantumCircuit(2)
94
+ qc.h(0)
95
+ qc.cx(0, 1)
96
+ qc.measure_all()
97
+
98
+ # Transpile for backend
99
+ transpiled_qc = transpile(qc, backend=backend, optimization_level=3)
100
+
101
+ # Run with Sampler
102
+ sampler = Sampler(backend)
103
+ job = sampler.run([transpiled_qc], shots=1024)
104
+
105
+ # Retrieve results
106
+ result = job.result()
107
+ counts = result[0].data.meas.get_counts()
108
+ print(counts)
109
+ ```
110
+
111
+ ### Job Management
112
+
113
+ ```python
114
+ # Submit job
115
+ job = sampler.run([qc], shots=1024)
116
+
117
+ # Get job ID (save for later retrieval)
118
+ job_id = job.job_id()
119
+ print(f"Job ID: {job_id}")
120
+
121
+ # Check job status
122
+ print(job.status())
123
+
124
+ # Wait for completion
125
+ result = job.result()
126
+
127
+ # Retrieve job later
128
+ service = QiskitRuntimeService()
129
+ retrieved_job = service.job(job_id)
130
+ result = retrieved_job.result()
131
+ ```
132
+
133
+ ### Job Queuing
134
+
135
+ ```python
136
+ # Check queue position
137
+ job_status = job.status()
138
+ print(f"Queue position: {job.queue_position()}")
139
+
140
+ # Cancel job if needed
141
+ job.cancel()
142
+ ```
143
+
144
+ ## Session Mode
145
+
146
+ Use sessions for iterative algorithms (VQE, QAOA) to reduce queue time:
147
+
148
+ ```python
149
+ from qiskit_ibm_runtime import Session, SamplerV2 as Sampler
150
+
151
+ service = QiskitRuntimeService()
152
+ backend = service.backend("ibm_brisbane")
153
+
154
+ with Session(backend=backend) as session:
155
+ sampler = Sampler(session=session)
156
+
157
+ # Multiple iterations in same session
158
+ for iteration in range(10):
159
+ # Parameterized circuit
160
+ qc = create_parameterized_circuit(params[iteration])
161
+ job = sampler.run([qc], shots=1024)
162
+ result = job.result()
163
+
164
+ # Update parameters based on results
165
+ params[iteration + 1] = optimize(result)
166
+ ```
167
+
168
+ Session benefits:
169
+ - Reduced queue waiting between iterations
170
+ - Guaranteed backend availability during session
171
+ - Better for variational algorithms
172
+
173
+ ## Batch Mode
174
+
175
+ Use batch mode for independent parallel jobs:
176
+
177
+ ```python
178
+ from qiskit_ibm_runtime import Batch, SamplerV2 as Sampler
179
+
180
+ service = QiskitRuntimeService()
181
+ backend = service.backend("ibm_brisbane")
182
+
183
+ with Batch(backend=backend) as batch:
184
+ sampler = Sampler(session=batch)
185
+
186
+ # Submit multiple independent jobs
187
+ jobs = []
188
+ for qc in circuit_list:
189
+ job = sampler.run([qc], shots=1024)
190
+ jobs.append(job)
191
+
192
+ # Collect all results
193
+ results = [job.result() for job in jobs]
194
+ ```
195
+
196
+ ## Local Simulators
197
+
198
+ ### StatevectorSampler (Ideal Simulation)
199
+
200
+ ```python
201
+ from qiskit.primitives import StatevectorSampler
202
+
203
+ sampler = StatevectorSampler()
204
+ result = sampler.run([qc], shots=1024).result()
205
+ counts = result[0].data.meas.get_counts()
206
+ ```
207
+
208
+ ### Aer Simulator (Realistic Noise)
209
+
210
+ ```python
211
+ from qiskit_aer import AerSimulator
212
+ from qiskit_ibm_runtime import SamplerV2 as Sampler
213
+
214
+ # Ideal simulation
215
+ simulator = AerSimulator()
216
+
217
+ # Simulate with backend noise model
218
+ backend = service.backend("ibm_brisbane")
219
+ noisy_simulator = AerSimulator.from_backend(backend)
220
+
221
+ # Run simulation
222
+ transpiled_qc = transpile(qc, simulator)
223
+ sampler = Sampler(simulator)
224
+ job = sampler.run([transpiled_qc], shots=1024)
225
+ result = job.result()
226
+ ```
227
+
228
+ ### Aer GPU Acceleration
229
+
230
+ ```python
231
+ # Use GPU for faster simulation
232
+ simulator = AerSimulator(method='statevector', device='GPU')
233
+ ```
234
+
235
+ ## Third-Party Providers
236
+
237
+ ### IonQ
238
+
239
+ IonQ offers trapped-ion quantum computers with all-to-all connectivity:
240
+
241
+ ```python
242
+ from qiskit_ionq import IonQProvider
243
+
244
+ provider = IonQProvider("YOUR_IONQ_API_TOKEN")
245
+
246
+ # List IonQ backends
247
+ backends = provider.backends()
248
+ backend = provider.get_backend("ionq_qpu")
249
+
250
+ # Run circuit
251
+ job = backend.run(qc, shots=1024)
252
+ result = job.result()
253
+ ```
254
+
255
+ ### Amazon Braket
256
+
257
+ ```python
258
+ from qiskit_braket_provider import BraketProvider
259
+
260
+ provider = BraketProvider()
261
+
262
+ # List available devices
263
+ backends = provider.backends()
264
+
265
+ # Use specific device
266
+ backend = provider.get_backend("Rigetti")
267
+ job = backend.run(qc, shots=1024)
268
+ result = job.result()
269
+ ```
270
+
271
+ ## Error Mitigation
272
+
273
+ ### Measurement Error Mitigation
274
+
275
+ ```python
276
+ from qiskit_ibm_runtime import SamplerV2 as Sampler, Options
277
+
278
+ # Configure error mitigation
279
+ options = Options()
280
+ options.resilience_level = 1 # 0=none, 1=minimal, 2=moderate, 3=heavy
281
+
282
+ sampler = Sampler(backend, options=options)
283
+ job = sampler.run([qc], shots=1024)
284
+ result = job.result()
285
+ ```
286
+
287
+ ### Error Mitigation Levels
288
+
289
+ - **Level 0**: No mitigation
290
+ - **Level 1**: Readout error mitigation
291
+ - **Level 2**: Level 1 + gate error mitigation
292
+ - **Level 3**: Level 2 + advanced techniques
293
+
294
+ **Qiskit's Samplomatic package** can reduce sampling overhead by up to 100x with probabilistic error cancellation.
295
+
296
+ ### Zero Noise Extrapolation (ZNE)
297
+
298
+ ```python
299
+ options = Options()
300
+ options.resilience_level = 2
301
+ options.resilience.zne_mitigation = True
302
+
303
+ sampler = Sampler(backend, options=options)
304
+ ```
305
+
306
+ ## Monitoring Usage and Costs
307
+
308
+ ### Check Account Usage
309
+
310
+ ```python
311
+ # For IBM Quantum
312
+ service = QiskitRuntimeService()
313
+
314
+ # Check remaining credits
315
+ print(service.usage())
316
+ ```
317
+
318
+ ### Estimate Job Cost
319
+
320
+ ```python
321
+ from qiskit_ibm_runtime import EstimatorV2 as Estimator
322
+
323
+ backend = service.backend("ibm_brisbane")
324
+
325
+ # Estimate job cost
326
+ estimator = Estimator(backend)
327
+ # Cost depends on circuit complexity and shots
328
+ ```
329
+
330
+ ## Best Practices
331
+
332
+ ### 1. Always Transpile Before Running
333
+
334
+ ```python
335
+ # Bad: Run without transpilation
336
+ job = sampler.run([qc], shots=1024)
337
+
338
+ # Good: Transpile first
339
+ qc_transpiled = transpile(qc, backend=backend, optimization_level=3)
340
+ job = sampler.run([qc_transpiled], shots=1024)
341
+ ```
342
+
343
+ ### 2. Test with Simulators First
344
+
345
+ ```python
346
+ # Test with noisy simulator before hardware
347
+ noisy_sim = AerSimulator.from_backend(backend)
348
+ qc_test = transpile(qc, noisy_sim, optimization_level=3)
349
+
350
+ # Verify results look reasonable
351
+ # Then run on hardware
352
+ ```
353
+
354
+ ### 3. Use Appropriate Shot Counts
355
+
356
+ ```python
357
+ # For optimization algorithms: fewer shots (100-1000)
358
+ # For final measurements: more shots (10000+)
359
+
360
+ # Adaptive shots based on stage
361
+ shots_optimization = 500
362
+ shots_final = 10000
363
+ ```
364
+
365
+ ### 4. Choose Backend Strategically
366
+
367
+ ```python
368
+ # For testing: Use least busy backend
369
+ backend = service.least_busy(min_num_qubits=5)
370
+
371
+ # For production: Use backend matching requirements
372
+ backend = service.backend("ibm_brisbane") # 127 qubits
373
+ ```
374
+
375
+ ### 5. Use Sessions for Variational Algorithms
376
+
377
+ Sessions are ideal for VQE, QAOA, and other iterative algorithms.
378
+
379
+ ### 6. Monitor Job Status
380
+
381
+ ```python
382
+ import time
383
+
384
+ job = sampler.run([qc], shots=1024)
385
+
386
+ while job.status().name not in ['DONE', 'ERROR', 'CANCELLED']:
387
+ print(f"Status: {job.status().name}")
388
+ time.sleep(10)
389
+
390
+ result = job.result()
391
+ ```
392
+
393
+ ## Troubleshooting
394
+
395
+ ### Issue: "Backend not found"
396
+ ```python
397
+ # List available backends
398
+ print([b.name for b in service.backends()])
399
+ ```
400
+
401
+ ### Issue: "Invalid credentials"
402
+ ```python
403
+ # Re-save credentials
404
+ QiskitRuntimeService.save_account(
405
+ channel="ibm_quantum",
406
+ token="YOUR_TOKEN",
407
+ overwrite=True
408
+ )
409
+ ```
410
+
411
+ ### Issue: Long queue times
412
+ ```python
413
+ # Use least busy backend
414
+ backend = service.least_busy(min_num_qubits=5)
415
+
416
+ # Or use batch mode for multiple independent jobs
417
+ ```
418
+
419
+ ### Issue: Job fails with "Circuit too large"
420
+ ```python
421
+ # Reduce circuit complexity
422
+ # Use higher transpilation optimization
423
+ qc_opt = transpile(qc, backend=backend, optimization_level=3)
424
+ ```
425
+
426
+ ## Backend Comparison
427
+
428
+ | Provider | Connectivity | Gate Set | Notes |
429
+ |----------|-------------|----------|--------|
430
+ | IBM Quantum | Limited | CX, RZ, SX, X | 100+ qubit systems, high quality |
431
+ | IonQ | All-to-all | GPI, GPI2, MS | Trapped ion, low error rates |
432
+ | Rigetti | Limited | CZ, RZ, RX | Superconducting qubits |
433
+ | Oxford Quantum Circuits | Limited | ECR, RZ, SX | Coaxmon technology |
@@ -0,0 +1,197 @@
1
+ # Quantum Circuit Building
2
+
3
+ ## Creating a Quantum Circuit
4
+
5
+ Create circuits using the `QuantumCircuit` class:
6
+
7
+ ```python
8
+ from qiskit import QuantumCircuit
9
+
10
+ # Create a circuit with 3 qubits
11
+ qc = QuantumCircuit(3)
12
+
13
+ # Create a circuit with 3 qubits and 3 classical bits
14
+ qc = QuantumCircuit(3, 3)
15
+ ```
16
+
17
+ ## Single-Qubit Gates
18
+
19
+ ### Pauli Gates
20
+
21
+ ```python
22
+ qc.x(0) # NOT/Pauli-X gate on qubit 0
23
+ qc.y(1) # Pauli-Y gate on qubit 1
24
+ qc.z(2) # Pauli-Z gate on qubit 2
25
+ ```
26
+
27
+ ### Hadamard Gate
28
+
29
+ Creates superposition:
30
+
31
+ ```python
32
+ qc.h(0) # Hadamard gate on qubit 0
33
+ ```
34
+
35
+ ### Phase Gates
36
+
37
+ ```python
38
+ qc.s(0) # S gate (√Z)
39
+ qc.t(0) # T gate (√S)
40
+ qc.p(π/4, 0) # Phase gate with custom angle
41
+ ```
42
+
43
+ ### Rotation Gates
44
+
45
+ ```python
46
+ from math import pi
47
+
48
+ qc.rx(pi/2, 0) # Rotation around X-axis
49
+ qc.ry(pi/4, 1) # Rotation around Y-axis
50
+ qc.rz(pi/3, 2) # Rotation around Z-axis
51
+ ```
52
+
53
+ ## Multi-Qubit Gates
54
+
55
+ ### CNOT (Controlled-NOT)
56
+
57
+ ```python
58
+ qc.cx(0, 1) # CNOT with control=0, target=1
59
+ ```
60
+
61
+ ### Controlled Gates
62
+
63
+ ```python
64
+ qc.cy(0, 1) # Controlled-Y
65
+ qc.cz(0, 1) # Controlled-Z
66
+ qc.ch(0, 1) # Controlled-Hadamard
67
+ ```
68
+
69
+ ### SWAP Gate
70
+
71
+ ```python
72
+ qc.swap(0, 1) # Swap qubits 0 and 1
73
+ ```
74
+
75
+ ### Toffoli (CCX) Gate
76
+
77
+ ```python
78
+ qc.ccx(0, 1, 2) # Toffoli with controls=0,1 and target=2
79
+ ```
80
+
81
+ ## Measurements
82
+
83
+ Add measurements to read qubit states:
84
+
85
+ ```python
86
+ # Measure all qubits
87
+ qc.measure_all()
88
+
89
+ # Measure specific qubits to specific classical bits
90
+ qc.measure(0, 0) # Measure qubit 0 to classical bit 0
91
+ qc.measure([0, 1], [0, 1]) # Measure qubits 0,1 to bits 0,1
92
+ ```
93
+
94
+ ## Circuit Composition
95
+
96
+ ### Combining Circuits
97
+
98
+ ```python
99
+ qc1 = QuantumCircuit(2)
100
+ qc1.h(0)
101
+
102
+ qc2 = QuantumCircuit(2)
103
+ qc2.cx(0, 1)
104
+
105
+ # Compose circuits
106
+ qc_combined = qc1.compose(qc2)
107
+ ```
108
+
109
+ ### Tensor Product
110
+
111
+ ```python
112
+ qc1 = QuantumCircuit(1)
113
+ qc1.h(0)
114
+
115
+ qc2 = QuantumCircuit(1)
116
+ qc2.x(0)
117
+
118
+ # Create larger circuit from smaller ones
119
+ qc_tensor = qc1.tensor(qc2) # Results in 2-qubit circuit
120
+ ```
121
+
122
+ ## Barriers and Labels
123
+
124
+ ```python
125
+ qc.barrier() # Add visual barrier in circuit
126
+ qc.barrier([0, 1]) # Barrier on specific qubits
127
+
128
+ # Add labels for clarity
129
+ qc.barrier(label="Initialization")
130
+ ```
131
+
132
+ ## Circuit Properties
133
+
134
+ ```python
135
+ print(qc.num_qubits) # Number of qubits
136
+ print(qc.num_clbits) # Number of classical bits
137
+ print(qc.depth()) # Circuit depth
138
+ print(qc.size()) # Total gate count
139
+ print(qc.count_ops()) # Dictionary of gate counts
140
+ ```
141
+
142
+ ## Example: Bell State
143
+
144
+ Create entanglement between two qubits:
145
+
146
+ ```python
147
+ qc = QuantumCircuit(2)
148
+ qc.h(0) # Superposition on qubit 0
149
+ qc.cx(0, 1) # Entangle qubit 0 and 1
150
+ qc.measure_all() # Measure both qubits
151
+ ```
152
+
153
+ ## Example: Quantum Fourier Transform (QFT)
154
+
155
+ ```python
156
+ from math import pi
157
+
158
+ def qft(n):
159
+ qc = QuantumCircuit(n)
160
+ for j in range(n):
161
+ qc.h(j)
162
+ for k in range(j+1, n):
163
+ qc.cp(pi/2**(k-j), k, j)
164
+ return qc
165
+
166
+ # Create 3-qubit QFT
167
+ qc_qft = qft(3)
168
+ ```
169
+
170
+ ## Parameterized Circuits
171
+
172
+ Create circuits with parameters for variational algorithms:
173
+
174
+ ```python
175
+ from qiskit.circuit import Parameter
176
+
177
+ theta = Parameter('θ')
178
+ qc = QuantumCircuit(1)
179
+ qc.ry(theta, 0)
180
+
181
+ # Bind parameter value
182
+ qc_bound = qc.assign_parameters({theta: pi/4})
183
+ ```
184
+
185
+ ## Circuit Operations
186
+
187
+ ```python
188
+ # Inverse of a circuit
189
+ qc_inverse = qc.inverse()
190
+
191
+ # Decompose gates to basis gates
192
+ qc_decomposed = qc.decompose()
193
+
194
+ # Draw circuit (returns string or diagram)
195
+ print(qc.draw())
196
+ print(qc.draw('mpl')) # Matplotlib figure
197
+ ```