@synsci/cli-darwin-x64-baseline 1.1.76 → 1.1.78

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (830) hide show
  1. package/bin/skills/adaptyv/SKILL.md +114 -0
  2. package/bin/skills/adaptyv/reference/api_reference.md +308 -0
  3. package/bin/skills/adaptyv/reference/examples.md +913 -0
  4. package/bin/skills/adaptyv/reference/experiments.md +360 -0
  5. package/bin/skills/adaptyv/reference/protein_optimization.md +637 -0
  6. package/bin/skills/aeon/SKILL.md +374 -0
  7. package/bin/skills/aeon/references/anomaly_detection.md +154 -0
  8. package/bin/skills/aeon/references/classification.md +144 -0
  9. package/bin/skills/aeon/references/clustering.md +123 -0
  10. package/bin/skills/aeon/references/datasets_benchmarking.md +387 -0
  11. package/bin/skills/aeon/references/distances.md +256 -0
  12. package/bin/skills/aeon/references/forecasting.md +140 -0
  13. package/bin/skills/aeon/references/networks.md +289 -0
  14. package/bin/skills/aeon/references/regression.md +118 -0
  15. package/bin/skills/aeon/references/segmentation.md +163 -0
  16. package/bin/skills/aeon/references/similarity_search.md +187 -0
  17. package/bin/skills/aeon/references/transformations.md +246 -0
  18. package/bin/skills/alphafold-database/SKILL.md +513 -0
  19. package/bin/skills/alphafold-database/references/api_reference.md +423 -0
  20. package/bin/skills/anndata/SKILL.md +400 -0
  21. package/bin/skills/anndata/references/best_practices.md +525 -0
  22. package/bin/skills/anndata/references/concatenation.md +396 -0
  23. package/bin/skills/anndata/references/data_structure.md +314 -0
  24. package/bin/skills/anndata/references/io_operations.md +404 -0
  25. package/bin/skills/anndata/references/manipulation.md +516 -0
  26. package/bin/skills/arboreto/SKILL.md +243 -0
  27. package/bin/skills/arboreto/references/algorithms.md +138 -0
  28. package/bin/skills/arboreto/references/basic_inference.md +151 -0
  29. package/bin/skills/arboreto/references/distributed_computing.md +242 -0
  30. package/bin/skills/arboreto/scripts/basic_grn_inference.py +97 -0
  31. package/bin/skills/astropy/SKILL.md +331 -0
  32. package/bin/skills/astropy/references/coordinates.md +273 -0
  33. package/bin/skills/astropy/references/cosmology.md +307 -0
  34. package/bin/skills/astropy/references/fits.md +396 -0
  35. package/bin/skills/astropy/references/tables.md +489 -0
  36. package/bin/skills/astropy/references/time.md +404 -0
  37. package/bin/skills/astropy/references/units.md +178 -0
  38. package/bin/skills/astropy/references/wcs_and_other_modules.md +373 -0
  39. package/bin/skills/benchling-integration/SKILL.md +480 -0
  40. package/bin/skills/benchling-integration/references/api_endpoints.md +883 -0
  41. package/bin/skills/benchling-integration/references/authentication.md +379 -0
  42. package/bin/skills/benchling-integration/references/sdk_reference.md +774 -0
  43. package/bin/skills/biopython/SKILL.md +443 -0
  44. package/bin/skills/biopython/references/advanced.md +577 -0
  45. package/bin/skills/biopython/references/alignment.md +362 -0
  46. package/bin/skills/biopython/references/blast.md +455 -0
  47. package/bin/skills/biopython/references/databases.md +484 -0
  48. package/bin/skills/biopython/references/phylogenetics.md +566 -0
  49. package/bin/skills/biopython/references/sequence_io.md +285 -0
  50. package/bin/skills/biopython/references/structure.md +564 -0
  51. package/bin/skills/biorxiv-database/SKILL.md +483 -0
  52. package/bin/skills/biorxiv-database/references/api_reference.md +280 -0
  53. package/bin/skills/biorxiv-database/scripts/biorxiv_search.py +445 -0
  54. package/bin/skills/bioservices/SKILL.md +361 -0
  55. package/bin/skills/bioservices/references/identifier_mapping.md +685 -0
  56. package/bin/skills/bioservices/references/services_reference.md +636 -0
  57. package/bin/skills/bioservices/references/workflow_patterns.md +811 -0
  58. package/bin/skills/bioservices/scripts/batch_id_converter.py +347 -0
  59. package/bin/skills/bioservices/scripts/compound_cross_reference.py +378 -0
  60. package/bin/skills/bioservices/scripts/pathway_analysis.py +309 -0
  61. package/bin/skills/bioservices/scripts/protein_analysis_workflow.py +408 -0
  62. package/bin/skills/brenda-database/SKILL.md +719 -0
  63. package/bin/skills/brenda-database/references/api_reference.md +537 -0
  64. package/bin/skills/brenda-database/scripts/brenda_queries.py +844 -0
  65. package/bin/skills/brenda-database/scripts/brenda_visualization.py +772 -0
  66. package/bin/skills/brenda-database/scripts/enzyme_pathway_builder.py +1053 -0
  67. package/bin/skills/cellxgene-census/SKILL.md +511 -0
  68. package/bin/skills/cellxgene-census/references/census_schema.md +182 -0
  69. package/bin/skills/cellxgene-census/references/common_patterns.md +351 -0
  70. package/bin/skills/chembl-database/SKILL.md +389 -0
  71. package/bin/skills/chembl-database/references/api_reference.md +272 -0
  72. package/bin/skills/chembl-database/scripts/example_queries.py +278 -0
  73. package/bin/skills/cirq/SKILL.md +346 -0
  74. package/bin/skills/cirq/references/building.md +307 -0
  75. package/bin/skills/cirq/references/experiments.md +572 -0
  76. package/bin/skills/cirq/references/hardware.md +515 -0
  77. package/bin/skills/cirq/references/noise.md +515 -0
  78. package/bin/skills/cirq/references/simulation.md +350 -0
  79. package/bin/skills/cirq/references/transformation.md +416 -0
  80. package/bin/skills/clinicaltrials-database/SKILL.md +507 -0
  81. package/bin/skills/clinicaltrials-database/references/api_reference.md +358 -0
  82. package/bin/skills/clinicaltrials-database/scripts/query_clinicaltrials.py +215 -0
  83. package/bin/skills/clinpgx-database/SKILL.md +638 -0
  84. package/bin/skills/clinpgx-database/references/api_reference.md +757 -0
  85. package/bin/skills/clinpgx-database/scripts/query_clinpgx.py +518 -0
  86. package/bin/skills/clinvar-database/SKILL.md +362 -0
  87. package/bin/skills/clinvar-database/references/api_reference.md +227 -0
  88. package/bin/skills/clinvar-database/references/clinical_significance.md +218 -0
  89. package/bin/skills/clinvar-database/references/data_formats.md +358 -0
  90. package/bin/skills/cobrapy/SKILL.md +463 -0
  91. package/bin/skills/cobrapy/references/api_quick_reference.md +655 -0
  92. package/bin/skills/cobrapy/references/workflows.md +593 -0
  93. package/bin/skills/cosmic-database/SKILL.md +336 -0
  94. package/bin/skills/cosmic-database/references/cosmic_data_reference.md +220 -0
  95. package/bin/skills/cosmic-database/scripts/download_cosmic.py +231 -0
  96. package/bin/skills/dask/SKILL.md +456 -0
  97. package/bin/skills/dask/references/arrays.md +497 -0
  98. package/bin/skills/dask/references/bags.md +468 -0
  99. package/bin/skills/dask/references/best-practices.md +277 -0
  100. package/bin/skills/dask/references/dataframes.md +368 -0
  101. package/bin/skills/dask/references/futures.md +541 -0
  102. package/bin/skills/dask/references/schedulers.md +504 -0
  103. package/bin/skills/datacommons-client/SKILL.md +255 -0
  104. package/bin/skills/datacommons-client/references/getting_started.md +417 -0
  105. package/bin/skills/datacommons-client/references/node.md +250 -0
  106. package/bin/skills/datacommons-client/references/observation.md +185 -0
  107. package/bin/skills/datacommons-client/references/resolve.md +246 -0
  108. package/bin/skills/datamol/SKILL.md +706 -0
  109. package/bin/skills/datamol/references/conformers_module.md +131 -0
  110. package/bin/skills/datamol/references/core_api.md +130 -0
  111. package/bin/skills/datamol/references/descriptors_viz.md +195 -0
  112. package/bin/skills/datamol/references/fragments_scaffolds.md +174 -0
  113. package/bin/skills/datamol/references/io_module.md +109 -0
  114. package/bin/skills/datamol/references/reactions_data.md +218 -0
  115. package/bin/skills/deepchem/SKILL.md +597 -0
  116. package/bin/skills/deepchem/references/api_reference.md +303 -0
  117. package/bin/skills/deepchem/references/workflows.md +491 -0
  118. package/bin/skills/deepchem/scripts/graph_neural_network.py +338 -0
  119. package/bin/skills/deepchem/scripts/predict_solubility.py +224 -0
  120. package/bin/skills/deepchem/scripts/transfer_learning.py +375 -0
  121. package/bin/skills/deeptools/SKILL.md +531 -0
  122. package/bin/skills/deeptools/assets/quick_reference.md +58 -0
  123. package/bin/skills/deeptools/references/effective_genome_sizes.md +116 -0
  124. package/bin/skills/deeptools/references/normalization_methods.md +410 -0
  125. package/bin/skills/deeptools/references/tools_reference.md +533 -0
  126. package/bin/skills/deeptools/references/workflows.md +474 -0
  127. package/bin/skills/deeptools/scripts/validate_files.py +195 -0
  128. package/bin/skills/deeptools/scripts/workflow_generator.py +454 -0
  129. package/bin/skills/denario/SKILL.md +215 -0
  130. package/bin/skills/denario/references/examples.md +494 -0
  131. package/bin/skills/denario/references/installation.md +213 -0
  132. package/bin/skills/denario/references/llm_configuration.md +265 -0
  133. package/bin/skills/denario/references/research_pipeline.md +471 -0
  134. package/bin/skills/diffdock/SKILL.md +483 -0
  135. package/bin/skills/diffdock/assets/batch_template.csv +4 -0
  136. package/bin/skills/diffdock/assets/custom_inference_config.yaml +90 -0
  137. package/bin/skills/diffdock/references/confidence_and_limitations.md +182 -0
  138. package/bin/skills/diffdock/references/parameters_reference.md +163 -0
  139. package/bin/skills/diffdock/references/workflows_examples.md +392 -0
  140. package/bin/skills/diffdock/scripts/analyze_results.py +334 -0
  141. package/bin/skills/diffdock/scripts/prepare_batch_csv.py +254 -0
  142. package/bin/skills/diffdock/scripts/setup_check.py +278 -0
  143. package/bin/skills/dnanexus-integration/SKILL.md +383 -0
  144. package/bin/skills/dnanexus-integration/references/app-development.md +247 -0
  145. package/bin/skills/dnanexus-integration/references/configuration.md +646 -0
  146. package/bin/skills/dnanexus-integration/references/data-operations.md +400 -0
  147. package/bin/skills/dnanexus-integration/references/job-execution.md +412 -0
  148. package/bin/skills/dnanexus-integration/references/python-sdk.md +523 -0
  149. package/bin/skills/document-skills/docx/LICENSE.txt +30 -0
  150. package/bin/skills/document-skills/docx/SKILL.md +233 -0
  151. package/bin/skills/document-skills/docx/docx-js.md +350 -0
  152. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-chart.xsd +1499 -0
  153. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-chartDrawing.xsd +146 -0
  154. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-diagram.xsd +1085 -0
  155. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-lockedCanvas.xsd +11 -0
  156. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-main.xsd +3081 -0
  157. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-picture.xsd +23 -0
  158. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-spreadsheetDrawing.xsd +185 -0
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  160. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/pml.xsd +1676 -0
  161. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/shared-additionalCharacteristics.xsd +28 -0
  162. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/shared-bibliography.xsd +144 -0
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  193. package/bin/skills/document-skills/docx/ooxml/scripts/validate.py +69 -0
  194. package/bin/skills/document-skills/docx/ooxml/scripts/validation/__init__.py +15 -0
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1
+ # General Signal Processing
2
+
3
+ ## Overview
4
+
5
+ NeuroKit2 provides comprehensive signal processing utilities applicable to any time series data. These functions support filtering, transformation, peak detection, decomposition, and analysis operations that work across all signal types.
6
+
7
+ ## Preprocessing Functions
8
+
9
+ ### signal_filter()
10
+
11
+ Apply frequency-domain filtering to remove noise or isolate frequency bands.
12
+
13
+ ```python
14
+ filtered = nk.signal_filter(signal, sampling_rate=1000, lowcut=None, highcut=None,
15
+ method='butterworth', order=5)
16
+ ```
17
+
18
+ **Filter types (via lowcut/highcut combinations):**
19
+
20
+ **Lowpass** (highcut only):
21
+ ```python
22
+ lowpass = nk.signal_filter(signal, sampling_rate=1000, highcut=50)
23
+ ```
24
+ - Removes frequencies above highcut
25
+ - Smooths signal, removes high-frequency noise
26
+
27
+ **Highpass** (lowcut only):
28
+ ```python
29
+ highpass = nk.signal_filter(signal, sampling_rate=1000, lowcut=0.5)
30
+ ```
31
+ - Removes frequencies below lowcut
32
+ - Removes baseline drift, DC offset
33
+
34
+ **Bandpass** (both lowcut and highcut):
35
+ ```python
36
+ bandpass = nk.signal_filter(signal, sampling_rate=1000, lowcut=0.5, highcut=50)
37
+ ```
38
+ - Retains frequencies between lowcut and highcut
39
+ - Isolates specific frequency band
40
+
41
+ **Bandstop/Notch** (powerline removal):
42
+ ```python
43
+ notch = nk.signal_filter(signal, sampling_rate=1000, method='powerline', powerline=50)
44
+ ```
45
+ - Removes 50 or 60 Hz powerline noise
46
+ - Narrow notch filter
47
+
48
+ **Methods:**
49
+ - `'butterworth'` (default): Smooth frequency response, flat passband
50
+ - `'bessel'`: Linear phase, minimal ringing
51
+ - `'chebyshev1'`: Steeper rolloff, ripple in passband
52
+ - `'chebyshev2'`: Steeper rolloff, ripple in stopband
53
+ - `'elliptic'`: Steepest rolloff, ripple in both bands
54
+ - `'powerline'`: Notch filter for 50/60 Hz
55
+
56
+ **Order parameter:**
57
+ - Higher order: Steeper transition, more ringing
58
+ - Lower order: Gentler transition, less ringing
59
+ - Typical: 2-5 for physiological signals
60
+
61
+ ### signal_sanitize()
62
+
63
+ Remove invalid values (NaN, inf) and optionally interpolate.
64
+
65
+ ```python
66
+ clean_signal = nk.signal_sanitize(signal, interpolate=True)
67
+ ```
68
+
69
+ **Use cases:**
70
+ - Handle missing data points
71
+ - Remove artifacts marked as NaN
72
+ - Prepare signal for algorithms requiring continuous data
73
+
74
+ ### signal_resample()
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+
76
+ Change sampling rate of signal (upsample or downsample).
77
+
78
+ ```python
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+ resampled = nk.signal_resample(signal, sampling_rate=1000, desired_sampling_rate=500,
80
+ method='interpolation')
81
+ ```
82
+
83
+ **Methods:**
84
+ - `'interpolation'`: Cubic spline interpolation
85
+ - `'FFT'`: Frequency-domain resampling
86
+ - `'poly'`: Polyphase filtering (best for downsampling)
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+
88
+ **Use cases:**
89
+ - Match sampling rates across multi-modal recordings
90
+ - Reduce data size (downsample)
91
+ - Increase temporal resolution (upsample)
92
+
93
+ ### signal_fillmissing()
94
+
95
+ Interpolate missing or invalid data points.
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+
97
+ ```python
98
+ filled = nk.signal_fillmissing(signal, method='linear')
99
+ ```
100
+
101
+ **Methods:**
102
+ - `'linear'`: Linear interpolation
103
+ - `'nearest'`: Nearest neighbor
104
+ - `'pad'`: Forward/backward fill
105
+ - `'cubic'`: Cubic spline
106
+ - `'polynomial'`: Polynomial fitting
107
+
108
+ ## Transformation Functions
109
+
110
+ ### signal_detrend()
111
+
112
+ Remove slow trends from signal.
113
+
114
+ ```python
115
+ detrended = nk.signal_detrend(signal, method='polynomial', order=1)
116
+ ```
117
+
118
+ **Methods:**
119
+ - `'polynomial'`: Fit and subtract polynomial (order 1 = linear)
120
+ - `'loess'`: Locally weighted regression
121
+ - `'tarvainen2002'`: Smoothness priors detrending
122
+
123
+ **Use cases:**
124
+ - Remove baseline drift
125
+ - Stabilize mean before analysis
126
+ - Prepare for stationarity-assuming algorithms
127
+
128
+ ### signal_decompose()
129
+
130
+ Decompose signal into constituent components.
131
+
132
+ ```python
133
+ components = nk.signal_decompose(signal, sampling_rate=1000, method='emd')
134
+ ```
135
+
136
+ **Methods:**
137
+
138
+ **Empirical Mode Decomposition (EMD):**
139
+ ```python
140
+ components = nk.signal_decompose(signal, sampling_rate=1000, method='emd')
141
+ ```
142
+ - Data-adaptive decomposition into Intrinsic Mode Functions (IMFs)
143
+ - Each IMF represents different frequency content (high to low)
144
+ - No predefined basis functions
145
+
146
+ **Singular Spectrum Analysis (SSA):**
147
+ ```python
148
+ components = nk.signal_decompose(signal, method='ssa')
149
+ ```
150
+ - Decomposes into trend, oscillations, and noise
151
+ - Based on eigenvalue decomposition of trajectory matrix
152
+
153
+ **Wavelet decomposition:**
154
+ - Time-frequency representation
155
+ - Localized in both time and frequency
156
+
157
+ **Returns:**
158
+ - Dictionary with component signals
159
+ - Trend, oscillatory components, residual
160
+
161
+ **Use cases:**
162
+ - Isolate physiological rhythms
163
+ - Separate signal from noise
164
+ - Multi-scale analysis
165
+
166
+ ### signal_recompose()
167
+
168
+ Reconstruct signal from decomposed components.
169
+
170
+ ```python
171
+ reconstructed = nk.signal_recompose(components, indices=[1, 2, 3])
172
+ ```
173
+
174
+ **Use case:**
175
+ - Selective reconstruction after decomposition
176
+ - Remove specific IMFs or components
177
+ - Adaptive filtering
178
+
179
+ ### signal_binarize()
180
+
181
+ Convert continuous signal to binary (0/1) based on threshold.
182
+
183
+ ```python
184
+ binary = nk.signal_binarize(signal, method='threshold', threshold=0.5)
185
+ ```
186
+
187
+ **Methods:**
188
+ - `'threshold'`: Simple threshold
189
+ - `'median'`: Median-based
190
+ - `'mean'`: Mean-based
191
+ - `'quantile'`: Percentile-based
192
+
193
+ **Use case:**
194
+ - Event detection from continuous signal
195
+ - Trigger extraction
196
+ - State classification
197
+
198
+ ### signal_distort()
199
+
200
+ Add controlled noise or artifacts for testing.
201
+
202
+ ```python
203
+ distorted = nk.signal_distort(signal, sampling_rate=1000, noise_amplitude=0.1,
204
+ noise_frequency=50, artifacts_amplitude=0.5)
205
+ ```
206
+
207
+ **Parameters:**
208
+ - `noise_amplitude`: Gaussian noise level
209
+ - `noise_frequency`: Sinusoidal interference (e.g., powerline)
210
+ - `artifacts_amplitude`: Random spike artifacts
211
+ - `artifacts_number`: Number of artifacts to add
212
+
213
+ **Use cases:**
214
+ - Algorithm robustness testing
215
+ - Preprocessing method evaluation
216
+ - Realistic data simulation
217
+
218
+ ### signal_interpolate()
219
+
220
+ Interpolate signal at new time points or fill gaps.
221
+
222
+ ```python
223
+ interpolated = nk.signal_interpolate(x_values, y_values, x_new=None, method='quadratic')
224
+ ```
225
+
226
+ **Methods:**
227
+ - `'linear'`, `'quadratic'`, `'cubic'`: Polynomial interpolation
228
+ - `'nearest'`: Nearest neighbor
229
+ - `'monotone_cubic'`: Preserves monotonicity
230
+
231
+ **Use case:**
232
+ - Convert irregular samples to regular grid
233
+ - Upsample for visualization
234
+ - Align signals with different time bases
235
+
236
+ ### signal_merge()
237
+
238
+ Combine multiple signals with different sampling rates.
239
+
240
+ ```python
241
+ merged = nk.signal_merge(signal1, signal2, time1=None, time2=None, sampling_rate=None)
242
+ ```
243
+
244
+ **Use case:**
245
+ - Multi-modal signal integration
246
+ - Combine data from different devices
247
+ - Synchronize based on timestamps
248
+
249
+ ### signal_flatline()
250
+
251
+ Identify periods of constant signal (artifacts or sensor failure).
252
+
253
+ ```python
254
+ flatline_mask = nk.signal_flatline(signal, duration=5.0, sampling_rate=1000)
255
+ ```
256
+
257
+ **Returns:**
258
+ - Binary mask where True indicates flatline periods
259
+ - Duration threshold prevents false positives from normal stability
260
+
261
+ ### signal_noise()
262
+
263
+ Add various types of noise to signal.
264
+
265
+ ```python
266
+ noisy = nk.signal_noise(signal, sampling_rate=1000, noise_type='gaussian',
267
+ amplitude=0.1)
268
+ ```
269
+
270
+ **Noise types:**
271
+ - `'gaussian'`: White noise
272
+ - `'pink'`: 1/f noise (common in physiological signals)
273
+ - `'brown'`: Brownian (random walk)
274
+ - `'powerline'`: Sinusoidal interference (50/60 Hz)
275
+
276
+ ### signal_surrogate()
277
+
278
+ Generate surrogate signals preserving certain properties.
279
+
280
+ ```python
281
+ surrogate = nk.signal_surrogate(signal, method='IAAFT')
282
+ ```
283
+
284
+ **Methods:**
285
+ - `'IAAFT'`: Iterated Amplitude Adjusted Fourier Transform
286
+ - Preserves amplitude distribution and power spectrum
287
+ - `'random_shuffle'`: Random permutation (null hypothesis testing)
288
+
289
+ **Use case:**
290
+ - Nonlinearity testing
291
+ - Null hypothesis generation for statistical tests
292
+
293
+ ## Peak Detection and Correction
294
+
295
+ ### signal_findpeaks()
296
+
297
+ Detect local maxima (peaks) in signal.
298
+
299
+ ```python
300
+ peaks_dict = nk.signal_findpeaks(signal, height_min=None, height_max=None,
301
+ relative_height_min=None, relative_height_max=None)
302
+ ```
303
+
304
+ **Key parameters:**
305
+ - `height_min/max`: Absolute amplitude thresholds
306
+ - `relative_height_min/max`: Relative to signal range (0-1)
307
+ - `threshold`: Minimum prominence
308
+ - `distance`: Minimum samples between peaks
309
+
310
+ **Returns:**
311
+ - Dictionary with:
312
+ - `'Peaks'`: Peak indices
313
+ - `'Height'`: Peak amplitudes
314
+ - `'Distance'`: Inter-peak intervals
315
+
316
+ **Use cases:**
317
+ - Generic peak detection for any signal
318
+ - R-peaks, respiratory peaks, pulse peaks
319
+ - Event detection
320
+
321
+ ### signal_fixpeaks()
322
+
323
+ Correct detected peaks for artifacts and anomalies.
324
+
325
+ ```python
326
+ corrected = nk.signal_fixpeaks(peaks, sampling_rate=1000, iterative=True,
327
+ method='Kubios', interval_min=None, interval_max=None)
328
+ ```
329
+
330
+ **Methods:**
331
+ - `'Kubios'`: Kubios HRV software method (default)
332
+ - `'Malik1996'`: Task Force Standards (1996)
333
+ - `'Kamath1993'`: Kamath's approach
334
+
335
+ **Corrections:**
336
+ - Remove physiologically implausible intervals
337
+ - Interpolate missing peaks
338
+ - Remove extra detected peaks (duplicates)
339
+
340
+ **Use case:**
341
+ - Artifact correction in R-R intervals
342
+ - Improve HRV analysis quality
343
+ - Respiratory or pulse peak correction
344
+
345
+ ## Analysis Functions
346
+
347
+ ### signal_rate()
348
+
349
+ Compute instantaneous rate from event occurrences (peaks).
350
+
351
+ ```python
352
+ rate = nk.signal_rate(peaks, sampling_rate=1000, desired_length=None)
353
+ ```
354
+
355
+ **Method:**
356
+ - Calculate inter-event intervals
357
+ - Convert to events per minute
358
+ - Interpolate to match desired length
359
+
360
+ **Use case:**
361
+ - Heart rate from R-peaks
362
+ - Breathing rate from respiratory peaks
363
+ - Any periodic event rate
364
+
365
+ ### signal_period()
366
+
367
+ Find dominant period/frequency in signal.
368
+
369
+ ```python
370
+ period = nk.signal_period(signal, sampling_rate=1000, method='autocorrelation',
371
+ show=False)
372
+ ```
373
+
374
+ **Methods:**
375
+ - `'autocorrelation'`: Peak in autocorrelation function
376
+ - `'powerspectraldensity'`: Peak in frequency spectrum
377
+
378
+ **Returns:**
379
+ - Period in samples or seconds
380
+ - Frequency (1/period) in Hz
381
+
382
+ **Use case:**
383
+ - Detect dominant rhythm
384
+ - Estimate fundamental frequency
385
+ - Breathing rate, heart rate estimation
386
+
387
+ ### signal_phase()
388
+
389
+ Compute instantaneous phase of signal.
390
+
391
+ ```python
392
+ phase = nk.signal_phase(signal, method='hilbert')
393
+ ```
394
+
395
+ **Methods:**
396
+ - `'hilbert'`: Hilbert transform (analytic signal)
397
+ - `'wavelet'`: Wavelet-based phase
398
+
399
+ **Returns:**
400
+ - Phase in radians (-π to π) or 0 to 1 (normalized)
401
+
402
+ **Use cases:**
403
+ - Phase-locked analysis
404
+ - Synchronization measures
405
+ - Phase-amplitude coupling
406
+
407
+ ### signal_psd()
408
+
409
+ Compute Power Spectral Density.
410
+
411
+ ```python
412
+ psd, freqs = nk.signal_psd(signal, sampling_rate=1000, method='welch',
413
+ max_frequency=None, show=False)
414
+ ```
415
+
416
+ **Methods:**
417
+ - `'welch'`: Welch's periodogram (windowed FFT, default)
418
+ - `'multitapers'`: Multitaper method (superior spectral estimation)
419
+ - `'lomb'`: Lomb-Scargle (unevenly sampled data)
420
+ - `'burg'`: Autoregressive (parametric)
421
+
422
+ **Returns:**
423
+ - `psd`: Power at each frequency (units²/Hz)
424
+ - `freqs`: Frequency bins (Hz)
425
+
426
+ **Use case:**
427
+ - Frequency content analysis
428
+ - HRV frequency domain
429
+ - Spectral signatures
430
+
431
+ ### signal_power()
432
+
433
+ Compute power in specific frequency bands.
434
+
435
+ ```python
436
+ power_dict = nk.signal_power(signal, sampling_rate=1000, frequency_bands={
437
+ 'VLF': (0.003, 0.04),
438
+ 'LF': (0.04, 0.15),
439
+ 'HF': (0.15, 0.4)
440
+ }, method='welch')
441
+ ```
442
+
443
+ **Returns:**
444
+ - Dictionary with absolute and relative power per band
445
+ - Peak frequencies
446
+
447
+ **Use case:**
448
+ - HRV frequency analysis
449
+ - EEG band power
450
+ - Rhythm quantification
451
+
452
+ ### signal_autocor()
453
+
454
+ Compute autocorrelation function.
455
+
456
+ ```python
457
+ autocorr = nk.signal_autocor(signal, lag=1000, show=False)
458
+ ```
459
+
460
+ **Interpretation:**
461
+ - High autocorrelation at lag: signal repeats every lag samples
462
+ - Periodic signals: peaks at multiples of period
463
+ - Random signals: rapid decay to zero
464
+
465
+ **Use cases:**
466
+ - Detect periodicity
467
+ - Assess temporal structure
468
+ - Memory in signal
469
+
470
+ ### signal_zerocrossings()
471
+
472
+ Count zero crossings (sign changes).
473
+
474
+ ```python
475
+ n_crossings = nk.signal_zerocrossings(signal)
476
+ ```
477
+
478
+ **Interpretation:**
479
+ - More crossings: higher frequency content
480
+ - Related to dominant frequency (rough estimate)
481
+
482
+ **Use case:**
483
+ - Simple frequency estimation
484
+ - Signal regularity assessment
485
+
486
+ ### signal_changepoints()
487
+
488
+ Detect abrupt changes in signal properties (mean, variance).
489
+
490
+ ```python
491
+ changepoints = nk.signal_changepoints(signal, penalty=10, method='pelt', show=False)
492
+ ```
493
+
494
+ **Methods:**
495
+ - `'pelt'`: Pruned Exact Linear Time (fast, exact)
496
+ - `'binseg'`: Binary segmentation (faster, approximate)
497
+
498
+ **Parameters:**
499
+ - `penalty`: Controls sensitivity (higher = fewer changepoints)
500
+
501
+ **Returns:**
502
+ - Indices of detected changepoints
503
+ - Segments between changepoints
504
+
505
+ **Use cases:**
506
+ - Segment signal into states
507
+ - Detect transitions (e.g., sleep stages, arousal states)
508
+ - Automatic epoch definition
509
+
510
+ ### signal_synchrony()
511
+
512
+ Assess synchronization between two signals.
513
+
514
+ ```python
515
+ sync = nk.signal_synchrony(signal1, signal2, method='correlation')
516
+ ```
517
+
518
+ **Methods:**
519
+ - `'correlation'`: Pearson correlation
520
+ - `'coherence'`: Frequency-domain coherence
521
+ - `'mutual_information'`: Information-theoretic measure
522
+ - `'phase'`: Phase locking value
523
+
524
+ **Use cases:**
525
+ - Heart-brain coupling
526
+ - Inter-brain synchrony
527
+ - Multi-channel coordination
528
+
529
+ ### signal_smooth()
530
+
531
+ Apply smoothing to reduce noise.
532
+
533
+ ```python
534
+ smoothed = nk.signal_smooth(signal, method='convolution', kernel='boxzen', size=10)
535
+ ```
536
+
537
+ **Methods:**
538
+ - `'convolution'`: Apply kernel (boxcar, Gaussian, etc.)
539
+ - `'median'`: Median filter (robust to outliers)
540
+ - `'savgol'`: Savitzky-Golay filter (preserves peaks)
541
+ - `'loess'`: Locally weighted regression
542
+
543
+ **Kernel types (for convolution):**
544
+ - `'boxcar'`: Simple moving average
545
+ - `'gaussian'`: Gaussian-weighted average
546
+ - `'hann'`, `'hamming'`, `'blackman'`: Windowing functions
547
+
548
+ **Use cases:**
549
+ - Noise reduction
550
+ - Trend extraction
551
+ - Visualization enhancement
552
+
553
+ ### signal_timefrequency()
554
+
555
+ Time-frequency representation (spectrogram).
556
+
557
+ ```python
558
+ tf, time, freq = nk.signal_timefrequency(signal, sampling_rate=1000, method='stft',
559
+ max_frequency=50, show=False)
560
+ ```
561
+
562
+ **Methods:**
563
+ - `'stft'`: Short-Time Fourier Transform
564
+ - `'cwt'`: Continuous Wavelet Transform
565
+
566
+ **Returns:**
567
+ - `tf`: Time-frequency matrix (power at each time-frequency point)
568
+ - `time`: Time bins
569
+ - `freq`: Frequency bins
570
+
571
+ **Use cases:**
572
+ - Non-stationary signal analysis
573
+ - Time-varying frequency content
574
+ - EEG/MEG time-frequency analysis
575
+
576
+ ## Simulation
577
+
578
+ ### signal_simulate()
579
+
580
+ Generate various synthetic signals for testing.
581
+
582
+ ```python
583
+ signal = nk.signal_simulate(duration=10, sampling_rate=1000, frequency=[5, 10],
584
+ amplitude=[1.0, 0.5], noise=0.1)
585
+ ```
586
+
587
+ **Signal types:**
588
+ - Sinusoidal oscillations (specify frequencies)
589
+ - Multiple frequency components
590
+ - Gaussian noise
591
+ - Combinations
592
+
593
+ **Use cases:**
594
+ - Algorithm testing
595
+ - Method validation
596
+ - Educational demonstrations
597
+
598
+ ## Visualization
599
+
600
+ ### signal_plot()
601
+
602
+ Visualize signal and optional markers.
603
+
604
+ ```python
605
+ nk.signal_plot(signal, sampling_rate=1000, peaks=None, show=True)
606
+ ```
607
+
608
+ **Features:**
609
+ - Time axis in seconds
610
+ - Peak markers
611
+ - Multiple subplots for signal arrays
612
+
613
+ ## Practical Tips
614
+
615
+ **Choosing filter parameters:**
616
+ - **Lowcut**: Set below lowest frequency of interest
617
+ - **Highcut**: Set above highest frequency of interest
618
+ - **Order**: Start with 2-5, increase if transition too slow
619
+ - **Method**: Butterworth is safe default
620
+
621
+ **Handling edge effects:**
622
+ - Filtering introduces artifacts at signal edges
623
+ - Pad signal before filtering, then trim
624
+ - Or discard initial/final seconds
625
+
626
+ **Dealing with gaps:**
627
+ - Small gaps: `signal_fillmissing()` with interpolation
628
+ - Large gaps: Segment signal, analyze separately
629
+ - Mark gaps as NaN, use interpolation carefully
630
+
631
+ **Combining operations:**
632
+ ```python
633
+ # Typical preprocessing pipeline
634
+ signal = nk.signal_sanitize(raw_signal) # Remove invalid values
635
+ signal = nk.signal_filter(signal, sampling_rate=1000, lowcut=0.5, highcut=40) # Bandpass
636
+ signal = nk.signal_detrend(signal, method='polynomial', order=1) # Remove linear trend
637
+ ```
638
+
639
+ **Performance considerations:**
640
+ - Filtering: FFT-based methods faster for long signals
641
+ - Resampling: Downsample early in pipeline to speed up
642
+ - Large datasets: Process in chunks if memory-limited
643
+
644
+ ## References
645
+
646
+ - Virtanen, P., et al. (2020). SciPy 1.0: fundamental algorithms for scientific computing in Python. Nature methods, 17(3), 261-272.
647
+ - Tarvainen, M. P., Ranta-aho, P. O., & Karjalainen, P. A. (2002). An advanced detrending method with application to HRV analysis. IEEE Transactions on Biomedical Engineering, 49(2), 172-175.
648
+ - Huang, N. E., et al. (1998). The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis. Proceedings of the Royal Society of London A, 454(1971), 903-995.