@synsci/cli-darwin-x64-baseline 1.1.76 → 1.1.78

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (830) hide show
  1. package/bin/skills/adaptyv/SKILL.md +114 -0
  2. package/bin/skills/adaptyv/reference/api_reference.md +308 -0
  3. package/bin/skills/adaptyv/reference/examples.md +913 -0
  4. package/bin/skills/adaptyv/reference/experiments.md +360 -0
  5. package/bin/skills/adaptyv/reference/protein_optimization.md +637 -0
  6. package/bin/skills/aeon/SKILL.md +374 -0
  7. package/bin/skills/aeon/references/anomaly_detection.md +154 -0
  8. package/bin/skills/aeon/references/classification.md +144 -0
  9. package/bin/skills/aeon/references/clustering.md +123 -0
  10. package/bin/skills/aeon/references/datasets_benchmarking.md +387 -0
  11. package/bin/skills/aeon/references/distances.md +256 -0
  12. package/bin/skills/aeon/references/forecasting.md +140 -0
  13. package/bin/skills/aeon/references/networks.md +289 -0
  14. package/bin/skills/aeon/references/regression.md +118 -0
  15. package/bin/skills/aeon/references/segmentation.md +163 -0
  16. package/bin/skills/aeon/references/similarity_search.md +187 -0
  17. package/bin/skills/aeon/references/transformations.md +246 -0
  18. package/bin/skills/alphafold-database/SKILL.md +513 -0
  19. package/bin/skills/alphafold-database/references/api_reference.md +423 -0
  20. package/bin/skills/anndata/SKILL.md +400 -0
  21. package/bin/skills/anndata/references/best_practices.md +525 -0
  22. package/bin/skills/anndata/references/concatenation.md +396 -0
  23. package/bin/skills/anndata/references/data_structure.md +314 -0
  24. package/bin/skills/anndata/references/io_operations.md +404 -0
  25. package/bin/skills/anndata/references/manipulation.md +516 -0
  26. package/bin/skills/arboreto/SKILL.md +243 -0
  27. package/bin/skills/arboreto/references/algorithms.md +138 -0
  28. package/bin/skills/arboreto/references/basic_inference.md +151 -0
  29. package/bin/skills/arboreto/references/distributed_computing.md +242 -0
  30. package/bin/skills/arboreto/scripts/basic_grn_inference.py +97 -0
  31. package/bin/skills/astropy/SKILL.md +331 -0
  32. package/bin/skills/astropy/references/coordinates.md +273 -0
  33. package/bin/skills/astropy/references/cosmology.md +307 -0
  34. package/bin/skills/astropy/references/fits.md +396 -0
  35. package/bin/skills/astropy/references/tables.md +489 -0
  36. package/bin/skills/astropy/references/time.md +404 -0
  37. package/bin/skills/astropy/references/units.md +178 -0
  38. package/bin/skills/astropy/references/wcs_and_other_modules.md +373 -0
  39. package/bin/skills/benchling-integration/SKILL.md +480 -0
  40. package/bin/skills/benchling-integration/references/api_endpoints.md +883 -0
  41. package/bin/skills/benchling-integration/references/authentication.md +379 -0
  42. package/bin/skills/benchling-integration/references/sdk_reference.md +774 -0
  43. package/bin/skills/biopython/SKILL.md +443 -0
  44. package/bin/skills/biopython/references/advanced.md +577 -0
  45. package/bin/skills/biopython/references/alignment.md +362 -0
  46. package/bin/skills/biopython/references/blast.md +455 -0
  47. package/bin/skills/biopython/references/databases.md +484 -0
  48. package/bin/skills/biopython/references/phylogenetics.md +566 -0
  49. package/bin/skills/biopython/references/sequence_io.md +285 -0
  50. package/bin/skills/biopython/references/structure.md +564 -0
  51. package/bin/skills/biorxiv-database/SKILL.md +483 -0
  52. package/bin/skills/biorxiv-database/references/api_reference.md +280 -0
  53. package/bin/skills/biorxiv-database/scripts/biorxiv_search.py +445 -0
  54. package/bin/skills/bioservices/SKILL.md +361 -0
  55. package/bin/skills/bioservices/references/identifier_mapping.md +685 -0
  56. package/bin/skills/bioservices/references/services_reference.md +636 -0
  57. package/bin/skills/bioservices/references/workflow_patterns.md +811 -0
  58. package/bin/skills/bioservices/scripts/batch_id_converter.py +347 -0
  59. package/bin/skills/bioservices/scripts/compound_cross_reference.py +378 -0
  60. package/bin/skills/bioservices/scripts/pathway_analysis.py +309 -0
  61. package/bin/skills/bioservices/scripts/protein_analysis_workflow.py +408 -0
  62. package/bin/skills/brenda-database/SKILL.md +719 -0
  63. package/bin/skills/brenda-database/references/api_reference.md +537 -0
  64. package/bin/skills/brenda-database/scripts/brenda_queries.py +844 -0
  65. package/bin/skills/brenda-database/scripts/brenda_visualization.py +772 -0
  66. package/bin/skills/brenda-database/scripts/enzyme_pathway_builder.py +1053 -0
  67. package/bin/skills/cellxgene-census/SKILL.md +511 -0
  68. package/bin/skills/cellxgene-census/references/census_schema.md +182 -0
  69. package/bin/skills/cellxgene-census/references/common_patterns.md +351 -0
  70. package/bin/skills/chembl-database/SKILL.md +389 -0
  71. package/bin/skills/chembl-database/references/api_reference.md +272 -0
  72. package/bin/skills/chembl-database/scripts/example_queries.py +278 -0
  73. package/bin/skills/cirq/SKILL.md +346 -0
  74. package/bin/skills/cirq/references/building.md +307 -0
  75. package/bin/skills/cirq/references/experiments.md +572 -0
  76. package/bin/skills/cirq/references/hardware.md +515 -0
  77. package/bin/skills/cirq/references/noise.md +515 -0
  78. package/bin/skills/cirq/references/simulation.md +350 -0
  79. package/bin/skills/cirq/references/transformation.md +416 -0
  80. package/bin/skills/clinicaltrials-database/SKILL.md +507 -0
  81. package/bin/skills/clinicaltrials-database/references/api_reference.md +358 -0
  82. package/bin/skills/clinicaltrials-database/scripts/query_clinicaltrials.py +215 -0
  83. package/bin/skills/clinpgx-database/SKILL.md +638 -0
  84. package/bin/skills/clinpgx-database/references/api_reference.md +757 -0
  85. package/bin/skills/clinpgx-database/scripts/query_clinpgx.py +518 -0
  86. package/bin/skills/clinvar-database/SKILL.md +362 -0
  87. package/bin/skills/clinvar-database/references/api_reference.md +227 -0
  88. package/bin/skills/clinvar-database/references/clinical_significance.md +218 -0
  89. package/bin/skills/clinvar-database/references/data_formats.md +358 -0
  90. package/bin/skills/cobrapy/SKILL.md +463 -0
  91. package/bin/skills/cobrapy/references/api_quick_reference.md +655 -0
  92. package/bin/skills/cobrapy/references/workflows.md +593 -0
  93. package/bin/skills/cosmic-database/SKILL.md +336 -0
  94. package/bin/skills/cosmic-database/references/cosmic_data_reference.md +220 -0
  95. package/bin/skills/cosmic-database/scripts/download_cosmic.py +231 -0
  96. package/bin/skills/dask/SKILL.md +456 -0
  97. package/bin/skills/dask/references/arrays.md +497 -0
  98. package/bin/skills/dask/references/bags.md +468 -0
  99. package/bin/skills/dask/references/best-practices.md +277 -0
  100. package/bin/skills/dask/references/dataframes.md +368 -0
  101. package/bin/skills/dask/references/futures.md +541 -0
  102. package/bin/skills/dask/references/schedulers.md +504 -0
  103. package/bin/skills/datacommons-client/SKILL.md +255 -0
  104. package/bin/skills/datacommons-client/references/getting_started.md +417 -0
  105. package/bin/skills/datacommons-client/references/node.md +250 -0
  106. package/bin/skills/datacommons-client/references/observation.md +185 -0
  107. package/bin/skills/datacommons-client/references/resolve.md +246 -0
  108. package/bin/skills/datamol/SKILL.md +706 -0
  109. package/bin/skills/datamol/references/conformers_module.md +131 -0
  110. package/bin/skills/datamol/references/core_api.md +130 -0
  111. package/bin/skills/datamol/references/descriptors_viz.md +195 -0
  112. package/bin/skills/datamol/references/fragments_scaffolds.md +174 -0
  113. package/bin/skills/datamol/references/io_module.md +109 -0
  114. package/bin/skills/datamol/references/reactions_data.md +218 -0
  115. package/bin/skills/deepchem/SKILL.md +597 -0
  116. package/bin/skills/deepchem/references/api_reference.md +303 -0
  117. package/bin/skills/deepchem/references/workflows.md +491 -0
  118. package/bin/skills/deepchem/scripts/graph_neural_network.py +338 -0
  119. package/bin/skills/deepchem/scripts/predict_solubility.py +224 -0
  120. package/bin/skills/deepchem/scripts/transfer_learning.py +375 -0
  121. package/bin/skills/deeptools/SKILL.md +531 -0
  122. package/bin/skills/deeptools/assets/quick_reference.md +58 -0
  123. package/bin/skills/deeptools/references/effective_genome_sizes.md +116 -0
  124. package/bin/skills/deeptools/references/normalization_methods.md +410 -0
  125. package/bin/skills/deeptools/references/tools_reference.md +533 -0
  126. package/bin/skills/deeptools/references/workflows.md +474 -0
  127. package/bin/skills/deeptools/scripts/validate_files.py +195 -0
  128. package/bin/skills/deeptools/scripts/workflow_generator.py +454 -0
  129. package/bin/skills/denario/SKILL.md +215 -0
  130. package/bin/skills/denario/references/examples.md +494 -0
  131. package/bin/skills/denario/references/installation.md +213 -0
  132. package/bin/skills/denario/references/llm_configuration.md +265 -0
  133. package/bin/skills/denario/references/research_pipeline.md +471 -0
  134. package/bin/skills/diffdock/SKILL.md +483 -0
  135. package/bin/skills/diffdock/assets/batch_template.csv +4 -0
  136. package/bin/skills/diffdock/assets/custom_inference_config.yaml +90 -0
  137. package/bin/skills/diffdock/references/confidence_and_limitations.md +182 -0
  138. package/bin/skills/diffdock/references/parameters_reference.md +163 -0
  139. package/bin/skills/diffdock/references/workflows_examples.md +392 -0
  140. package/bin/skills/diffdock/scripts/analyze_results.py +334 -0
  141. package/bin/skills/diffdock/scripts/prepare_batch_csv.py +254 -0
  142. package/bin/skills/diffdock/scripts/setup_check.py +278 -0
  143. package/bin/skills/dnanexus-integration/SKILL.md +383 -0
  144. package/bin/skills/dnanexus-integration/references/app-development.md +247 -0
  145. package/bin/skills/dnanexus-integration/references/configuration.md +646 -0
  146. package/bin/skills/dnanexus-integration/references/data-operations.md +400 -0
  147. package/bin/skills/dnanexus-integration/references/job-execution.md +412 -0
  148. package/bin/skills/dnanexus-integration/references/python-sdk.md +523 -0
  149. package/bin/skills/document-skills/docx/LICENSE.txt +30 -0
  150. package/bin/skills/document-skills/docx/SKILL.md +233 -0
  151. package/bin/skills/document-skills/docx/docx-js.md +350 -0
  152. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-chart.xsd +1499 -0
  153. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-chartDrawing.xsd +146 -0
  154. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-diagram.xsd +1085 -0
  155. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-lockedCanvas.xsd +11 -0
  156. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-main.xsd +3081 -0
  157. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-picture.xsd +23 -0
  158. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/dml-spreadsheetDrawing.xsd +185 -0
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  160. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/pml.xsd +1676 -0
  161. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/shared-additionalCharacteristics.xsd +28 -0
  162. package/bin/skills/document-skills/docx/ooxml/schemas/ISO-IEC29500-4_2016/shared-bibliography.xsd +144 -0
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  193. package/bin/skills/document-skills/docx/ooxml/scripts/validate.py +69 -0
  194. package/bin/skills/document-skills/docx/ooxml/scripts/validation/__init__.py +15 -0
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1
+ # Complexity and Entropy Analysis
2
+
3
+ ## Overview
4
+
5
+ Complexity measures quantify the irregularity, unpredictability, and multiscale structure of time series signals. NeuroKit2 provides comprehensive entropy, fractal dimension, and nonlinear dynamics measures for assessing physiological signal complexity.
6
+
7
+ ## Main Function
8
+
9
+ ### complexity()
10
+
11
+ Compute multiple complexity metrics simultaneously for exploratory analysis.
12
+
13
+ ```python
14
+ complexity_indices = nk.complexity(signal, sampling_rate=1000, show=False)
15
+ ```
16
+
17
+ **Returns:**
18
+ - DataFrame with numerous complexity measures across categories:
19
+ - Entropy indices
20
+ - Fractal dimensions
21
+ - Nonlinear dynamics measures
22
+ - Information-theoretic metrics
23
+
24
+ **Use case:**
25
+ - Exploratory analysis to identify relevant measures
26
+ - Comprehensive signal characterization
27
+ - Comparative studies across signals
28
+
29
+ ## Parameter Optimization
30
+
31
+ Before computing complexity measures, optimal embedding parameters should be determined:
32
+
33
+ ### complexity_delay()
34
+
35
+ Determine optimal time delay (τ) for phase space reconstruction.
36
+
37
+ ```python
38
+ optimal_tau = nk.complexity_delay(signal, delay_max=100, method='fraser1986', show=False)
39
+ ```
40
+
41
+ **Methods:**
42
+ - `'fraser1986'`: Mutual information first minimum
43
+ - `'theiler1990'`: Autocorrelation first zero crossing
44
+ - `'casdagli1991'`: Cao's method
45
+
46
+ **Use for:** Embedding delay in entropy, attractor reconstruction
47
+
48
+ ### complexity_dimension()
49
+
50
+ Determine optimal embedding dimension (m).
51
+
52
+ ```python
53
+ optimal_m = nk.complexity_dimension(signal, delay=None, dimension_max=20,
54
+ method='afn', show=False)
55
+ ```
56
+
57
+ **Methods:**
58
+ - `'afn'`: Average False Nearest Neighbors
59
+ - `'fnn'`: False Nearest Neighbors
60
+ - `'correlation'`: Correlation dimension saturation
61
+
62
+ **Use for:** Entropy calculations, phase space reconstruction
63
+
64
+ ### complexity_tolerance()
65
+
66
+ Determine optimal tolerance (r) for entropy measures.
67
+
68
+ ```python
69
+ optimal_r = nk.complexity_tolerance(signal, method='sd', show=False)
70
+ ```
71
+
72
+ **Methods:**
73
+ - `'sd'`: Standard deviation-based (0.1-0.25 × SD typical)
74
+ - `'maxApEn'`: Maximize ApEn
75
+ - `'recurrence'`: Based on recurrence rate
76
+
77
+ **Use for:** Approximate entropy, sample entropy
78
+
79
+ ### complexity_k()
80
+
81
+ Determine optimal k parameter for Higuchi fractal dimension.
82
+
83
+ ```python
84
+ optimal_k = nk.complexity_k(signal, k_max=20, show=False)
85
+ ```
86
+
87
+ **Use for:** Higuchi fractal dimension calculation
88
+
89
+ ## Entropy Measures
90
+
91
+ Entropy quantifies randomness, unpredictability, and information content.
92
+
93
+ ### entropy_shannon()
94
+
95
+ Shannon entropy - classical information-theoretic measure.
96
+
97
+ ```python
98
+ shannon_entropy = nk.entropy_shannon(signal)
99
+ ```
100
+
101
+ **Interpretation:**
102
+ - Higher: more random, less predictable
103
+ - Lower: more regular, predictable
104
+ - Units: bits (information)
105
+
106
+ **Use cases:**
107
+ - General randomness assessment
108
+ - Information content
109
+ - Signal irregularity
110
+
111
+ ### entropy_approximate()
112
+
113
+ Approximate Entropy (ApEn) - regularity of patterns.
114
+
115
+ ```python
116
+ apen = nk.entropy_approximate(signal, delay=1, dimension=2, tolerance='sd')
117
+ ```
118
+
119
+ **Parameters:**
120
+ - `delay`: Time delay (τ)
121
+ - `dimension`: Embedding dimension (m)
122
+ - `tolerance`: Similarity threshold (r)
123
+
124
+ **Interpretation:**
125
+ - Lower ApEn: more regular, self-similar patterns
126
+ - Higher ApEn: more complex, irregular
127
+ - Sensitive to signal length (≥100-300 points recommended)
128
+
129
+ **Physiological applications:**
130
+ - HRV: reduced ApEn in heart disease
131
+ - EEG: altered ApEn in neurological disorders
132
+
133
+ ### entropy_sample()
134
+
135
+ Sample Entropy (SampEn) - improved ApEn.
136
+
137
+ ```python
138
+ sampen = nk.entropy_sample(signal, delay=1, dimension=2, tolerance='sd')
139
+ ```
140
+
141
+ **Advantages over ApEn:**
142
+ - Less dependent on signal length
143
+ - More consistent across recordings
144
+ - No self-matching bias
145
+
146
+ **Interpretation:**
147
+ - Same as ApEn but more reliable
148
+ - Preferred in most applications
149
+
150
+ **Typical values:**
151
+ - HRV: 0.5-2.5 (context-dependent)
152
+ - EEG: 0.3-1.5
153
+
154
+ ### entropy_multiscale()
155
+
156
+ Multiscale Entropy (MSE) - complexity across temporal scales.
157
+
158
+ ```python
159
+ mse = nk.entropy_multiscale(signal, scale=20, dimension=2, tolerance='sd',
160
+ method='MSEn', show=False)
161
+ ```
162
+
163
+ **Methods:**
164
+ - `'MSEn'`: Multiscale Sample Entropy
165
+ - `'MSApEn'`: Multiscale Approximate Entropy
166
+ - `'CMSE'`: Composite Multiscale Entropy
167
+ - `'RCMSE'`: Refined Composite Multiscale Entropy
168
+
169
+ **Interpretation:**
170
+ - Entropy at different coarse-graining scales
171
+ - Healthy/complex systems: high entropy across multiple scales
172
+ - Diseased/simpler systems: reduced entropy, especially at larger scales
173
+
174
+ **Use cases:**
175
+ - Distinguish true complexity from randomness
176
+ - White noise: constant across scales
177
+ - Pink noise/complexity: structured variation across scales
178
+
179
+ ### entropy_fuzzy()
180
+
181
+ Fuzzy Entropy - uses fuzzy membership functions.
182
+
183
+ ```python
184
+ fuzzen = nk.entropy_fuzzy(signal, delay=1, dimension=2, tolerance='sd', r=0.2)
185
+ ```
186
+
187
+ **Advantages:**
188
+ - More stable with noisy signals
189
+ - Fuzzy boundaries for pattern matching
190
+ - Better performance with short signals
191
+
192
+ ### entropy_permutation()
193
+
194
+ Permutation Entropy - based on ordinal patterns.
195
+
196
+ ```python
197
+ perment = nk.entropy_permutation(signal, delay=1, dimension=3)
198
+ ```
199
+
200
+ **Method:**
201
+ - Encodes signal into ordinal patterns (permutations)
202
+ - Counts pattern frequencies
203
+ - Robust to noise and non-stationarity
204
+
205
+ **Interpretation:**
206
+ - Lower: more regular ordinal structure
207
+ - Higher: more random ordering
208
+
209
+ **Use cases:**
210
+ - EEG analysis
211
+ - Anesthesia depth monitoring
212
+ - Fast computation
213
+
214
+ ### entropy_spectral()
215
+
216
+ Spectral Entropy - based on power spectrum.
217
+
218
+ ```python
219
+ spec_ent = nk.entropy_spectral(signal, sampling_rate=1000, bands=None)
220
+ ```
221
+
222
+ **Method:**
223
+ - Normalized Shannon entropy of power spectrum
224
+ - Quantifies frequency distribution regularity
225
+
226
+ **Interpretation:**
227
+ - 0: Single frequency (pure tone)
228
+ - 1: White noise (flat spectrum)
229
+
230
+ **Use cases:**
231
+ - EEG: spectral distribution changes with states
232
+ - Anesthesia monitoring
233
+
234
+ ### entropy_svd()
235
+
236
+ Singular Value Decomposition Entropy.
237
+
238
+ ```python
239
+ svd_ent = nk.entropy_svd(signal, delay=1, dimension=2)
240
+ ```
241
+
242
+ **Method:**
243
+ - SVD on trajectory matrix
244
+ - Entropy of singular value distribution
245
+
246
+ **Use cases:**
247
+ - Attractor complexity
248
+ - Deterministic vs. stochastic dynamics
249
+
250
+ ### entropy_differential()
251
+
252
+ Differential Entropy - continuous analog of Shannon entropy.
253
+
254
+ ```python
255
+ diff_ent = nk.entropy_differential(signal)
256
+ ```
257
+
258
+ **Use for:** Continuous probability distributions
259
+
260
+ ### Other Entropy Measures
261
+
262
+ **Tsallis Entropy:**
263
+ ```python
264
+ tsallis = nk.entropy_tsallis(signal, q=2)
265
+ ```
266
+ - Generalized entropy with parameter q
267
+ - q=1 reduces to Shannon entropy
268
+
269
+ **Rényi Entropy:**
270
+ ```python
271
+ renyi = nk.entropy_renyi(signal, alpha=2)
272
+ ```
273
+ - Generalized entropy with parameter α
274
+
275
+ **Additional specialized entropies:**
276
+ - `entropy_attention()`: Attention entropy
277
+ - `entropy_grid()`: Grid-based entropy
278
+ - `entropy_increment()`: Increment entropy
279
+ - `entropy_slope()`: Slope entropy
280
+ - `entropy_dispersion()`: Dispersion entropy
281
+ - `entropy_symbolicdynamic()`: Symbolic dynamics entropy
282
+ - `entropy_range()`: Range entropy
283
+ - `entropy_phase()`: Phase entropy
284
+ - `entropy_quadratic()`, `entropy_cumulative_residual()`, `entropy_rate()`: Specialized variants
285
+
286
+ ## Fractal Dimension Measures
287
+
288
+ Fractal dimensions characterize self-similarity and roughness.
289
+
290
+ ### fractal_katz()
291
+
292
+ Katz Fractal Dimension - waveform complexity.
293
+
294
+ ```python
295
+ kfd = nk.fractal_katz(signal)
296
+ ```
297
+
298
+ **Interpretation:**
299
+ - 1: straight line
300
+ - >1: increasing roughness and complexity
301
+ - Typical range: 1.0-2.0
302
+
303
+ **Advantages:**
304
+ - Simple, fast computation
305
+ - No parameter tuning
306
+
307
+ ### fractal_higuchi()
308
+
309
+ Higuchi Fractal Dimension - self-similarity.
310
+
311
+ ```python
312
+ hfd = nk.fractal_higuchi(signal, k_max=10)
313
+ ```
314
+
315
+ **Method:**
316
+ - Constructs k new time series from original
317
+ - Estimates dimension from length-scale relationship
318
+
319
+ **Interpretation:**
320
+ - Higher HFD: more complex, irregular
321
+ - Lower HFD: smoother, more regular
322
+
323
+ **Use cases:**
324
+ - EEG complexity
325
+ - HRV analysis
326
+ - Epilepsy detection
327
+
328
+ ### fractal_petrosian()
329
+
330
+ Petrosian Fractal Dimension - rapid estimation.
331
+
332
+ ```python
333
+ pfd = nk.fractal_petrosian(signal)
334
+ ```
335
+
336
+ **Advantages:**
337
+ - Fast computation
338
+ - Direct calculation (no curve fitting)
339
+
340
+ ### fractal_sevcik()
341
+
342
+ Sevcik Fractal Dimension - normalized waveform complexity.
343
+
344
+ ```python
345
+ sfd = nk.fractal_sevcik(signal)
346
+ ```
347
+
348
+ ### fractal_nld()
349
+
350
+ Normalized Length Density - curve length-based measure.
351
+
352
+ ```python
353
+ nld = nk.fractal_nld(signal)
354
+ ```
355
+
356
+ ### fractal_psdslope()
357
+
358
+ Power Spectral Density Slope - frequency-domain fractal measure.
359
+
360
+ ```python
361
+ slope = nk.fractal_psdslope(signal, sampling_rate=1000)
362
+ ```
363
+
364
+ **Method:**
365
+ - Linear fit to log-log power spectrum
366
+ - Slope β relates to fractal dimension
367
+
368
+ **Interpretation:**
369
+ - β ≈ 0: White noise (random)
370
+ - β ≈ -1: Pink noise (1/f, complex)
371
+ - β ≈ -2: Brown noise (Brownian motion)
372
+
373
+ ### fractal_hurst()
374
+
375
+ Hurst Exponent - long-range dependence.
376
+
377
+ ```python
378
+ hurst = nk.fractal_hurst(signal, show=False)
379
+ ```
380
+
381
+ **Interpretation:**
382
+ - H < 0.5: Anti-persistent (mean-reverting)
383
+ - H = 0.5: Random walk (white noise)
384
+ - H > 0.5: Persistent (trending, long-memory)
385
+
386
+ **Use cases:**
387
+ - Assess long-term correlations
388
+ - Financial time series
389
+ - HRV analysis
390
+
391
+ ### fractal_correlation()
392
+
393
+ Correlation Dimension - attractor dimensionality.
394
+
395
+ ```python
396
+ corr_dim = nk.fractal_correlation(signal, delay=1, dimension=10, radius=64)
397
+ ```
398
+
399
+ **Method:**
400
+ - Grassberger-Procaccia algorithm
401
+ - Estimates dimension of attractor in phase space
402
+
403
+ **Interpretation:**
404
+ - Low dimension: deterministic, low-dimensional chaos
405
+ - High dimension: high-dimensional chaos or noise
406
+
407
+ ### fractal_dfa()
408
+
409
+ Detrended Fluctuation Analysis - scaling exponent.
410
+
411
+ ```python
412
+ dfa_alpha = nk.fractal_dfa(signal, multifractal=False, q=2, show=False)
413
+ ```
414
+
415
+ **Interpretation:**
416
+ - α < 0.5: Anti-correlated
417
+ - α = 0.5: Uncorrelated (white noise)
418
+ - α = 1.0: 1/f noise (pink noise, healthy complexity)
419
+ - α = 1.5: Brownian noise
420
+ - α > 1.0: Persistent long-range correlations
421
+
422
+ **HRV applications:**
423
+ - α1 (short-term, 4-11 beats): Reflects autonomic regulation
424
+ - α2 (long-term, >11 beats): Long-range correlations
425
+ - Reduced α1: Cardiac pathology
426
+
427
+ ### fractal_mfdfa()
428
+
429
+ Multifractal DFA - multiscale fractal properties.
430
+
431
+ ```python
432
+ mfdfa_results = nk.fractal_mfdfa(signal, q=None, show=False)
433
+ ```
434
+
435
+ **Method:**
436
+ - Extends DFA to multiple q-orders
437
+ - Characterizes multifractal spectrum
438
+
439
+ **Returns:**
440
+ - Generalized Hurst exponents h(q)
441
+ - Multifractal spectrum f(α)
442
+ - Width indicates multifractality strength
443
+
444
+ **Use cases:**
445
+ - Detect multifractal structure
446
+ - HRV multifractality in health vs. disease
447
+ - EEG multiscale dynamics
448
+
449
+ ### fractal_tmf()
450
+
451
+ Multifractal Nonlinearity - deviation from monofractal.
452
+
453
+ ```python
454
+ tmf = nk.fractal_tmf(signal)
455
+ ```
456
+
457
+ **Interpretation:**
458
+ - Quantifies departure from simple scaling
459
+ - Higher: more multifractal structure
460
+
461
+ ### fractal_density()
462
+
463
+ Density Fractal Dimension.
464
+
465
+ ```python
466
+ density_fd = nk.fractal_density(signal)
467
+ ```
468
+
469
+ ### fractal_linelength()
470
+
471
+ Line Length - total variation measure.
472
+
473
+ ```python
474
+ linelength = nk.fractal_linelength(signal)
475
+ ```
476
+
477
+ **Use case:**
478
+ - Simple complexity proxy
479
+ - EEG seizure detection
480
+
481
+ ## Nonlinear Dynamics
482
+
483
+ ### complexity_lyapunov()
484
+
485
+ Largest Lyapunov Exponent - chaos and divergence.
486
+
487
+ ```python
488
+ lyap = nk.complexity_lyapunov(signal, delay=None, dimension=None,
489
+ sampling_rate=1000, show=False)
490
+ ```
491
+
492
+ **Interpretation:**
493
+ - λ < 0: Stable fixed point
494
+ - λ = 0: Periodic orbit
495
+ - λ > 0: Chaotic (nearby trajectories diverge exponentially)
496
+
497
+ **Use cases:**
498
+ - Detect chaos in physiological signals
499
+ - HRV: positive Lyapunov suggests nonlinear dynamics
500
+ - EEG: epilepsy detection (decreased λ before seizure)
501
+
502
+ ### complexity_lempelziv()
503
+
504
+ Lempel-Ziv Complexity - algorithmic complexity.
505
+
506
+ ```python
507
+ lz = nk.complexity_lempelziv(signal, symbolize='median')
508
+ ```
509
+
510
+ **Method:**
511
+ - Counts number of distinct patterns
512
+ - Coarse-grained measure of randomness
513
+
514
+ **Interpretation:**
515
+ - Lower: repetitive, predictable patterns
516
+ - Higher: diverse, unpredictable patterns
517
+
518
+ **Use cases:**
519
+ - EEG: consciousness levels, anesthesia
520
+ - HRV: autonomic complexity
521
+
522
+ ### complexity_rqa()
523
+
524
+ Recurrence Quantification Analysis - phase space recurrences.
525
+
526
+ ```python
527
+ rqa_indices = nk.complexity_rqa(signal, delay=1, dimension=3, tolerance='sd')
528
+ ```
529
+
530
+ **Metrics:**
531
+ - **Recurrence Rate (RR)**: Percentage of recurrent states
532
+ - **Determinism (DET)**: Percentage of recurrent points in lines
533
+ - **Laminarity (LAM)**: Percentage in vertical structures (laminar states)
534
+ - **Trapping Time (TT)**: Average vertical line length
535
+ - **Longest diagonal/vertical**: System predictability
536
+ - **Entropy (ENTR)**: Shannon entropy of line length distribution
537
+
538
+ **Interpretation:**
539
+ - High DET: deterministic dynamics
540
+ - High LAM: system trapped in specific states
541
+ - Low RR: random, non-recurrent dynamics
542
+
543
+ **Use cases:**
544
+ - Detect transitions in system dynamics
545
+ - Physiological state changes
546
+ - Nonlinear time series analysis
547
+
548
+ ### complexity_hjorth()
549
+
550
+ Hjorth Parameters - time-domain complexity.
551
+
552
+ ```python
553
+ hjorth = nk.complexity_hjorth(signal)
554
+ ```
555
+
556
+ **Metrics:**
557
+ - **Activity**: Variance of signal
558
+ - **Mobility**: Proportion of standard deviation of derivative to signal
559
+ - **Complexity**: Change in mobility with derivative
560
+
561
+ **Use cases:**
562
+ - EEG feature extraction
563
+ - Seizure detection
564
+ - Signal characterization
565
+
566
+ ### complexity_decorrelation()
567
+
568
+ Decorrelation Time - memory duration.
569
+
570
+ ```python
571
+ decorr_time = nk.complexity_decorrelation(signal, show=False)
572
+ ```
573
+
574
+ **Interpretation:**
575
+ - Time lag where autocorrelation drops below threshold
576
+ - Shorter: rapid fluctuations, short memory
577
+ - Longer: slow fluctuations, long memory
578
+
579
+ ### complexity_relativeroughness()
580
+
581
+ Relative Roughness - smoothness measure.
582
+
583
+ ```python
584
+ roughness = nk.complexity_relativeroughness(signal)
585
+ ```
586
+
587
+ ## Information Theory
588
+
589
+ ### fisher_information()
590
+
591
+ Fisher Information - measure of order.
592
+
593
+ ```python
594
+ fisher = nk.fisher_information(signal, delay=1, dimension=2)
595
+ ```
596
+
597
+ **Interpretation:**
598
+ - High: ordered, structured
599
+ - Low: disordered, random
600
+
601
+ **Use cases:**
602
+ - Combine with Shannon entropy (Fisher-Shannon plane)
603
+ - Characterize system complexity
604
+
605
+ ### fishershannon_information()
606
+
607
+ Fisher-Shannon Information Product.
608
+
609
+ ```python
610
+ fs = nk.fishershannon_information(signal)
611
+ ```
612
+
613
+ **Method:**
614
+ - Product of Fisher information and Shannon entropy
615
+ - Characterizes order-disorder balance
616
+
617
+ ### mutual_information()
618
+
619
+ Mutual Information - shared information between variables.
620
+
621
+ ```python
622
+ mi = nk.mutual_information(signal1, signal2, method='knn')
623
+ ```
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+
625
+ **Methods:**
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+ - `'knn'`: k-nearest neighbors (nonparametric)
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+ - `'kernel'`: Kernel density estimation
628
+ - `'binning'`: Histogram-based
629
+
630
+ **Use cases:**
631
+ - Coupling between signals
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+ - Feature selection
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+ - Nonlinear dependence
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+
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+ ## Practical Considerations
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+
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+ ### Signal Length Requirements
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+
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+ | Measure | Minimum Length | Optimal Length |
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+ |---------|---------------|----------------|
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+ | Shannon entropy | 50 | 200+ |
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+ | ApEn, SampEn | 100-300 | 500-1000 |
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+ | Multiscale entropy | 500 | 1000+ per scale |
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+ | DFA | 500 | 1000+ |
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+ | Lyapunov | 1000 | 5000+ |
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+ | Correlation dimension | 1000 | 5000+ |
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+
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+ ### Parameter Selection
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+
650
+ **General guidelines:**
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+ - Use parameter optimization functions first
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+ - Or use conventional defaults:
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+ - Delay (τ): 1 for HRV, autocorrelation first minimum for EEG
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+ - Dimension (m): 2-3 typical
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+ - Tolerance (r): 0.2 × SD common
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+
657
+ **Sensitivity:**
658
+ - Results can be parameter-sensitive
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+ - Report parameters used
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+ - Consider sensitivity analysis
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+
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+ ### Normalization and Preprocessing
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+
664
+ **Standardization:**
665
+ - Many measures sensitive to signal amplitude
666
+ - Z-score normalization often recommended
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+ - Detrending may be necessary
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+
669
+ **Stationarity:**
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+ - Some measures assume stationarity
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+ - Check with statistical tests (e.g., ADF test)
672
+ - Segment non-stationary signals
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+
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+ ### Interpretation
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+
676
+ **Context-dependent:**
677
+ - No universal "good" or "bad" complexity
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+ - Compare within-subject or between groups
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+ - Consider physiological context
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+
681
+ **Complexity vs. randomness:**
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+ - Maximum entropy ≠ maximum complexity
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+ - True complexity: structured variability
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+ - White noise: high entropy but low complexity (MSE distinguishes)
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+
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+ ## Applications
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+
688
+ **Cardiovascular:**
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+ - HRV complexity: reduced in heart disease, aging
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+ - DFA α1: prognostic marker post-MI
691
+
692
+ **Neuroscience:**
693
+ - EEG complexity: consciousness, anesthesia depth
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+ - Entropy: Alzheimer's, epilepsy, sleep stages
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+ - Permutation entropy: anesthesia monitoring
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+
697
+ **Psychology:**
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+ - Complexity loss in depression, anxiety
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+ - Increased regularity under stress
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+
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+ **Aging:**
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+ - "Complexity loss" with aging across systems
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+ - Reduced multiscale complexity
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+
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+ **Critical transitions:**
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+ - Complexity changes before state transitions
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+ - Early warning signals (critical slowing down)
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+
709
+ ## References
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+
711
+ - Pincus, S. M. (1991). Approximate entropy as a measure of system complexity. Proceedings of the National Academy of Sciences, 88(6), 2297-2301.
712
+ - Richman, J. S., & Moorman, J. R. (2000). Physiological time-series analysis using approximate entropy and sample entropy. American Journal of Physiology-Heart and Circulatory Physiology, 278(6), H2039-H2049.
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+ - Peng, C. K., et al. (1995). Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. Chaos, 5(1), 82-87.
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+ - Costa, M., Goldberger, A. L., & Peng, C. K. (2005). Multiscale entropy analysis of biological signals. Physical review E, 71(2), 021906.
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+ - Grassberger, P., & Procaccia, I. (1983). Measuring the strangeness of strange attractors. Physica D: Nonlinear Phenomena, 9(1-2), 189-208.