pharmaobservatory 0.1.2 → 0.1.4

data/lib/pharmaobservatory/api/biomarkers_api.rb

@@ -19,599 +19,55 @@ module PharmaObservatory
     def initialize(api_client = ApiClient.default)
       @api_client = api_client
     end
-    # Assay-provider ledger
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersAssayProviderLedger200Response]
-    def biomarkers_assay_provider_ledger(id, opts = {})
-      data, _status_code, _headers = biomarkers_assay_provider_ledger_with_http_info(id, opts)
-      data
-    end
-
-    # Assay-provider ledger
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersAssayProviderLedger200Response, Integer, Hash)>] BiomarkersAssayProviderLedger200Response data, response status code and response headers
-    def biomarkers_assay_provider_ledger_with_http_info(id, opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_assay_provider_ledger ...'
-      end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_assay_provider_ledger"
-      end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/assay_provider_ledger'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersAssayProviderLedger200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_assay_provider_ledger",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_assay_provider_ledger\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
-      end
-      return data, status_code, headers
-    end
-
-    # Actionable biomarkers
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersCgi200Response]
-    def biomarkers_cgi(id, opts = {})
-      data, _status_code, _headers = biomarkers_cgi_with_http_info(id, opts)
-      data
-    end
-
-    # Actionable biomarkers
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersCgi200Response, Integer, Hash)>] BiomarkersCgi200Response data, response status code and response headers
-    def biomarkers_cgi_with_http_info(id, opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_cgi ...'
-      end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_cgi"
-      end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/cgi'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersCgi200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_cgi",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_cgi\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
-      end
-      return data, status_code, headers
-    end
-
-    # Coverage by traversal
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersCoverageByTraversal200Response]
-    def biomarkers_coverage_by_traversal(id, opts = {})
-      data, _status_code, _headers = biomarkers_coverage_by_traversal_with_http_info(id, opts)
-      data
-    end
-
-    # Coverage by traversal
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersCoverageByTraversal200Response, Integer, Hash)>] BiomarkersCoverageByTraversal200Response data, response status code and response headers
-    def biomarkers_coverage_by_traversal_with_http_info(id, opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_coverage_by_traversal ...'
-      end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_coverage_by_traversal"
-      end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/coverage_by_traversal'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersCoverageByTraversal200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_coverage_by_traversal",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_coverage_by_traversal\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
-      end
-      return data, status_code, headers
-    end
-
-    # Evidence over time
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersEvidenceOverTime200Response]
-    def biomarkers_evidence_over_time(id, opts = {})
-      data, _status_code, _headers = biomarkers_evidence_over_time_with_http_info(id, opts)
-      data
-    end
-
-    # Evidence over time
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersEvidenceOverTime200Response, Integer, Hash)>] BiomarkersEvidenceOverTime200Response data, response status code and response headers
-    def biomarkers_evidence_over_time_with_http_info(id, opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_evidence_over_time ...'
-      end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_evidence_over_time"
-      end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/evidence_over_time'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersEvidenceOverTime200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_evidence_over_time",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_evidence_over_time\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
-      end
-      return data, status_code, headers
-    end
-
-    # FDA biomarker qualification projects
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersFdaBqp200Response]
-    def biomarkers_fda_bqp(id, opts = {})
-      data, _status_code, _headers = biomarkers_fda_bqp_with_http_info(id, opts)
-      data
-    end
-
-    # FDA biomarker qualification projects
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersFdaBqp200Response, Integer, Hash)>] BiomarkersFdaBqp200Response data, response status code and response headers
-    def biomarkers_fda_bqp_with_http_info(id, opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_fda_bqp ...'
-      end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_fda_bqp"
-      end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/fda_bqp'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersFdaBqp200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_fda_bqp",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_fda_bqp\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
-      end
-      return data, status_code, headers
-    end
-
-    # FDA companion diagnostic assertions
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersFdaCdx200Response]
-    def biomarkers_fda_cdx(id, opts = {})
-      data, _status_code, _headers = biomarkers_fda_cdx_with_http_info(id, opts)
-      data
-    end
-
-    # FDA companion diagnostic assertions
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersFdaCdx200Response, Integer, Hash)>] BiomarkersFdaCdx200Response data, response status code and response headers
-    def biomarkers_fda_cdx_with_http_info(id, opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_fda_cdx ...'
-      end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_fda_cdx"
-      end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/fda_cdx'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersFdaCdx200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_fda_cdx",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_fda_cdx\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
-      end
-      return data, status_code, headers
-    end
-
-    # One biomarkers record
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersGet200Response]
-    def biomarkers_get(id, opts = {})
-      data, _status_code, _headers = biomarkers_get_with_http_info(id, opts)
-      data
-    end
-
-    # One biomarkers record
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersGet200Response, Integer, Hash)>] BiomarkersGet200Response data, response status code and response headers
-    def biomarkers_get_with_http_info(id, opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_get ...'
-      end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_get"
-      end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersGet200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_get",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_get\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
-      end
-      return data, status_code, headers
-    end
-
-    # Biomarker evidence, labeled by type
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersHubTierTables200Response]
-    def biomarkers_hub_tier_tables(opts = {})
-      data, _status_code, _headers = biomarkers_hub_tier_tables_with_http_info(opts)
-      data
-    end
-
-    # Biomarker evidence, labeled by type
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersHubTierTables200Response, Integer, Hash)>] BiomarkersHubTierTables200Response data, response status code and response headers
-    def biomarkers_hub_tier_tables_with_http_info(opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_hub_tier_tables ...'
-      end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/hub_tier_tables'
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersHubTierTables200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_hub_tier_tables",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_hub_tier_tables\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
-      end
-      return data, status_code, headers
-    end
-
-    # Biomarker identity
+    # FDA biomarker qualification projects
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersIdentity200Response]
-    def biomarkers_identity(id, opts = {})
-      data, _status_code, _headers = biomarkers_identity_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerBqpAssertionsResponse]
+    def biomarkers_biomarker_bqp_assertions(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_bqp_assertions_with_http_info(id, opts)
       data
     end
 
-    # Biomarker identity
+    # FDA biomarker qualification projects
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersIdentity200Response, Integer, Hash)>] BiomarkersIdentity200Response data, response status code and response headers
-    def biomarkers_identity_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerBqpAssertionsResponse, Integer, Hash)>] BiomarkerBqpAssertionsResponse data, response status code and response headers
+    def biomarkers_biomarker_bqp_assertions_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_identity ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_bqp_assertions ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_identity"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_bqp_assertions"
       end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/identity'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersIdentity200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_identity",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_identity\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_bqp_assertions, must be smaller than or equal to 500.'
       end
-      return data, status_code, headers
-    end
-
-    # Biomarkers
-    # @param [Hash] opts the optional parameters
-    # @option opts [String] :cursor 
-    # @option opts [String] :dir 
-    # @option opts [Integer] :evidence 
-    # @option opts [Boolean] :facets 
-    # @option opts [String] :identity 
-    # @option opts [String] :kind 
-    # @option opts [Integer] :limit 
-    # @option opts [String] :q 
-    # @option opts [String] :sort 
-    # @option opts [Integer] :validated 
-    # @return [BiomarkersList200Response]
-    def biomarkers_list(opts = {})
-      data, _status_code, _headers = biomarkers_list_with_http_info(opts)
-      data
-    end
 
-    # Biomarkers
-    # @param [Hash] opts the optional parameters
-    # @option opts [String] :cursor 
-    # @option opts [String] :dir 
-    # @option opts [Integer] :evidence 
-    # @option opts [Boolean] :facets 
-    # @option opts [String] :identity 
-    # @option opts [String] :kind 
-    # @option opts [Integer] :limit 
-    # @option opts [String] :q 
-    # @option opts [String] :sort 
-    # @option opts [Integer] :validated 
-    # @return [Array<(BiomarkersList200Response, Integer, Hash)>] BiomarkersList200Response data, response status code and response headers
-    def biomarkers_list_with_http_info(opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_list ...'
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_bqp_assertions, must be greater than or equal to 1.'
       end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers'
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_bqp_assertions'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
       query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
-      query_params[:'dir'] = opts[:'dir'] if !opts[:'dir'].nil?
-      query_params[:'evidence'] = opts[:'evidence'] if !opts[:'evidence'].nil?
-      query_params[:'facets'] = opts[:'facets'] if !opts[:'facets'].nil?
-      query_params[:'identity'] = opts[:'identity'] if !opts[:'identity'].nil?
-      query_params[:'kind'] = opts[:'kind'] if !opts[:'kind'].nil?
       query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
-      query_params[:'q'] = opts[:'q'] if !opts[:'q'].nil?
       query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
-      query_params[:'validated'] = opts[:'validated'] if !opts[:'validated'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -625,13 +81,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersList200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerBqpAssertionsResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_list",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_bqp_assertions",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -642,98 +98,60 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_list\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_bqp_assertions\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Trial-cited literature mentions
+    # FDA companion diagnostic assertions
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersLiterature200Response]
-    def biomarkers_literature(id, opts = {})
-      data, _status_code, _headers = biomarkers_literature_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerCdxAssertionsResponse]
+    def biomarkers_biomarker_cdx_assertions(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_cdx_assertions_with_http_info(id, opts)
       data
     end
 
-    # Trial-cited literature mentions
+    # FDA companion diagnostic assertions
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersLiterature200Response, Integer, Hash)>] BiomarkersLiterature200Response data, response status code and response headers
-    def biomarkers_literature_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerCdxAssertionsResponse, Integer, Hash)>] BiomarkerCdxAssertionsResponse data, response status code and response headers
+    def biomarkers_biomarker_cdx_assertions_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_literature ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_cdx_assertions ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_literature"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_cdx_assertions"
       end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/literature'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersLiterature200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_literature",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_literature\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_cdx_assertions, must be smaller than or equal to 500.'
       end
-      return data, status_code, headers
-    end
 
-    # Target-disease associations
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersOtAssociation200Response]
-    def biomarkers_ot_association(id, opts = {})
-      data, _status_code, _headers = biomarkers_ot_association_with_http_info(id, opts)
-      data
-    end
-
-    # Target-disease associations
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersOtAssociation200Response, Integer, Hash)>] BiomarkersOtAssociation200Response data, response status code and response headers
-    def biomarkers_ot_association_with_http_info(id, opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_ot_association ...'
-      end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_ot_association"
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_cdx_assertions, must be greater than or equal to 1.'
       end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/ot_association'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_cdx_assertions'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -747,13 +165,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersOtAssociation200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerCdxAssertionsResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_ot_association",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_cdx_assertions",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -764,98 +182,60 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_ot_association\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_cdx_assertions\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Population allele frequency
+    # Biomarker evidence
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersPopulationAlleleFrequency200Response]
-    def biomarkers_population_allele_frequency(id, opts = {})
-      data, _status_code, _headers = biomarkers_population_allele_frequency_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerEvidenceResponse]
+    def biomarkers_biomarker_evidence(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_evidence_with_http_info(id, opts)
       data
     end
 
-    # Population allele frequency
+    # Biomarker evidence
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersPopulationAlleleFrequency200Response, Integer, Hash)>] BiomarkersPopulationAlleleFrequency200Response data, response status code and response headers
-    def biomarkers_population_allele_frequency_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerEvidenceResponse, Integer, Hash)>] BiomarkerEvidenceResponse data, response status code and response headers
+    def biomarkers_biomarker_evidence_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_population_allele_frequency ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_evidence ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_population_allele_frequency"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_evidence"
       end
-      # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/population_allele_frequency'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
-
-      # query parameters
-      query_params = opts[:query_params] || {}
-
-      # header parameters
-      header_params = opts[:header_params] || {}
-      # HTTP header 'Accept' (if needed)
-      header_params['Accept'] = @api_client.select_header_accept(['application/json']) unless header_params['Accept']
-
-      # form parameters
-      form_params = opts[:form_params] || {}
-
-      # http body (model)
-      post_body = opts[:debug_body]
-
-      # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersPopulationAlleleFrequency200Response'
-
-      # auth_names
-      auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
-
-      new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_population_allele_frequency",
-        :header_params => header_params,
-        :query_params => query_params,
-        :form_params => form_params,
-        :body => post_body,
-        :auth_names => auth_names,
-        :return_type => return_type
-      )
-
-      data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
-      if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_population_allele_frequency\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_evidence, must be smaller than or equal to 500.'
       end
-      return data, status_code, headers
-    end
-
-    # Organizations publishing
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [BiomarkersPublishingOrg200Response]
-    def biomarkers_publishing_org(id, opts = {})
-      data, _status_code, _headers = biomarkers_publishing_org_with_http_info(id, opts)
-      data
-    end
 
-    # Organizations publishing
-    # @param id [String] 
-    # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersPublishingOrg200Response, Integer, Hash)>] BiomarkersPublishingOrg200Response data, response status code and response headers
-    def biomarkers_publishing_org_with_http_info(id, opts = {})
-      if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_publishing_org ...'
-      end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_publishing_org"
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_evidence, must be greater than or equal to 1.'
       end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/publishing_org'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_evidence'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -869,13 +249,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersPublishingOrg200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerEvidenceResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_publishing_org",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_evidence",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -886,37 +266,60 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_publishing_org\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_evidence\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Related biomarkers
+    # Trial-cited literature mentions
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersRelatedBiomarkers200Response]
-    def biomarkers_related_biomarkers(id, opts = {})
-      data, _status_code, _headers = biomarkers_related_biomarkers_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerLiteratureResponse]
+    def biomarkers_biomarker_literature(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_literature_with_http_info(id, opts)
       data
     end
 
-    # Related biomarkers
+    # Trial-cited literature mentions
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersRelatedBiomarkers200Response, Integer, Hash)>] BiomarkersRelatedBiomarkers200Response data, response status code and response headers
-    def biomarkers_related_biomarkers_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerLiteratureResponse, Integer, Hash)>] BiomarkerLiteratureResponse data, response status code and response headers
+    def biomarkers_biomarker_literature_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_related_biomarkers ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_literature ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_related_biomarkers"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_literature"
+      end
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_literature, must be smaller than or equal to 500.'
+      end
+
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_literature, must be greater than or equal to 1.'
       end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/related_biomarkers'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_literature'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -930,13 +333,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersRelatedBiomarkers200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerLiteratureResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_related_biomarkers",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_literature",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -947,37 +350,60 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_related_biomarkers\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_literature\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Related conditions
+    # Companies publishing on a biomarker
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersRelatedConditions200Response]
-    def biomarkers_related_conditions(id, opts = {})
-      data, _status_code, _headers = biomarkers_related_conditions_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerPublishingCompaniesResponse]
+    def biomarkers_biomarker_publishing_companies(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_publishing_companies_with_http_info(id, opts)
       data
     end
 
-    # Related conditions
+    # Companies publishing on a biomarker
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersRelatedConditions200Response, Integer, Hash)>] BiomarkersRelatedConditions200Response data, response status code and response headers
-    def biomarkers_related_conditions_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerPublishingCompaniesResponse, Integer, Hash)>] BiomarkerPublishingCompaniesResponse data, response status code and response headers
+    def biomarkers_biomarker_publishing_companies_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_related_conditions ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_publishing_companies ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_related_conditions"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_publishing_companies"
+      end
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_publishing_companies, must be smaller than or equal to 500.'
+      end
+
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_publishing_companies, must be greater than or equal to 1.'
       end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/related_conditions'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_publishing_companies'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -991,13 +417,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersRelatedConditions200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerPublishingCompaniesResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_related_conditions",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_publishing_companies",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -1008,37 +434,60 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_related_conditions\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_publishing_companies\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Related organisations
+    # Literature-extracted relations
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersRelatedOrganizations200Response]
-    def biomarkers_related_organizations(id, opts = {})
-      data, _status_code, _headers = biomarkers_related_organizations_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerRelationsResponse]
+    def biomarkers_biomarker_relations(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_relations_with_http_info(id, opts)
       data
     end
 
-    # Related organisations
+    # Literature-extracted relations
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersRelatedOrganizations200Response, Integer, Hash)>] BiomarkersRelatedOrganizations200Response data, response status code and response headers
-    def biomarkers_related_organizations_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerRelationsResponse, Integer, Hash)>] BiomarkerRelationsResponse data, response status code and response headers
+    def biomarkers_biomarker_relations_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_related_organizations ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_relations ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_related_organizations"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_relations"
+      end
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_relations, must be smaller than or equal to 500.'
+      end
+
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_relations, must be greater than or equal to 1.'
       end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/related_organizations'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_relations'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -1052,13 +501,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersRelatedOrganizations200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerRelationsResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_related_organizations",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_relations",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -1069,40 +518,60 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_related_organizations\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_relations\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Literature-extracted relations
+    # Human sample screening coverage (GDC)
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @option opts [String] :chemicals 
-    # @return [BiomarkersRelations200Response]
-    def biomarkers_relations(id, opts = {})
-      data, _status_code, _headers = biomarkers_relations_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerSampleCoverageResponse]
+    def biomarkers_biomarker_sample_coverage(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_sample_coverage_with_http_info(id, opts)
       data
     end
 
-    # Literature-extracted relations
+    # Human sample screening coverage (GDC)
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @option opts [String] :chemicals 
-    # @return [Array<(BiomarkersRelations200Response, Integer, Hash)>] BiomarkersRelations200Response data, response status code and response headers
-    def biomarkers_relations_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerSampleCoverageResponse, Integer, Hash)>] BiomarkerSampleCoverageResponse data, response status code and response headers
+    def biomarkers_biomarker_sample_coverage_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_relations ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_sample_coverage ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_relations"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_sample_coverage"
+      end
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_sample_coverage, must be smaller than or equal to 500.'
       end
+
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_sample_coverage, must be greater than or equal to 1.'
+      end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/relations'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_sample_coverage'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
-      query_params[:'chemicals'] = opts[:'chemicals'] if !opts[:'chemicals'].nil?
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -1116,13 +585,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersRelations200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerSampleCoverageResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_relations",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_sample_coverage",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -1133,40 +602,60 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_relations\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_sample_coverage\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Human sample screening reference
+    # Human sample screening reference (GDC cohorts)
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @option opts [Integer] :positive_samples 
-    # @return [BiomarkersSampleScreening200Response]
-    def biomarkers_sample_screening(id, opts = {})
-      data, _status_code, _headers = biomarkers_sample_screening_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerSamplePrevalenceResponse]
+    def biomarkers_biomarker_sample_prevalence(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_sample_prevalence_with_http_info(id, opts)
       data
     end
 
-    # Human sample screening reference
+    # Human sample screening reference (GDC cohorts)
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @option opts [Integer] :positive_samples 
-    # @return [Array<(BiomarkersSampleScreening200Response, Integer, Hash)>] BiomarkersSampleScreening200Response data, response status code and response headers
-    def biomarkers_sample_screening_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerSamplePrevalenceResponse, Integer, Hash)>] BiomarkerSamplePrevalenceResponse data, response status code and response headers
+    def biomarkers_biomarker_sample_prevalence_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_sample_screening ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_sample_prevalence ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_sample_screening"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_sample_prevalence"
+      end
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_sample_prevalence, must be smaller than or equal to 500.'
+      end
+
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_sample_prevalence, must be greater than or equal to 1.'
       end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/sample_screening'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_sample_prevalence'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
-      query_params[:'positive_samples'] = opts[:'positive_samples'] if !opts[:'positive_samples'].nil?
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -1180,13 +669,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersSampleScreening200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerSamplePrevalenceResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_sample_screening",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_sample_prevalence",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -1197,37 +686,60 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_sample_screening\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_sample_prevalence\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Trial mentions
+    # Biomarker validation ladder
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersTrialMention200Response]
-    def biomarkers_trial_mention(id, opts = {})
-      data, _status_code, _headers = biomarkers_trial_mention_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerValidationResponse]
+    def biomarkers_biomarker_validation(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_validation_with_http_info(id, opts)
       data
     end
 
-    # Trial mentions
+    # Biomarker validation ladder
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersTrialMention200Response, Integer, Hash)>] BiomarkersTrialMention200Response data, response status code and response headers
-    def biomarkers_trial_mention_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerValidationResponse, Integer, Hash)>] BiomarkerValidationResponse data, response status code and response headers
+    def biomarkers_biomarker_validation_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_trial_mention ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_validation ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_trial_mention"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_validation"
+      end
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_validation, must be smaller than or equal to 500.'
+      end
+
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_validation, must be greater than or equal to 1.'
       end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/trial_mention'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_validation'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -1241,13 +753,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersTrialMention200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerValidationResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_trial_mention",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_validation",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -1258,7 +770,7 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_trial_mention\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_validation\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
@@ -1266,29 +778,52 @@ module PharmaObservatory
     # Protein variant mentions
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersVariantMentions200Response]
-    def biomarkers_variant_mentions(id, opts = {})
-      data, _status_code, _headers = biomarkers_variant_mentions_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkerVariantMentionsResponse]
+    def biomarkers_biomarker_variant_mentions(id, opts = {})
+      data, _status_code, _headers = biomarkers_biomarker_variant_mentions_with_http_info(id, opts)
       data
     end
 
     # Protein variant mentions
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersVariantMentions200Response, Integer, Hash)>] BiomarkersVariantMentions200Response data, response status code and response headers
-    def biomarkers_variant_mentions_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkerVariantMentionsResponse, Integer, Hash)>] BiomarkerVariantMentionsResponse data, response status code and response headers
+    def biomarkers_biomarker_variant_mentions_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_variant_mentions ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_biomarker_variant_mentions ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_variant_mentions"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_biomarker_variant_mentions"
       end
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_variant_mentions, must be smaller than or equal to 500.'
+      end
+
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_biomarker_variant_mentions, must be greater than or equal to 1.'
+      end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/variant_mentions'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}/biomarker_variant_mentions'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -1302,13 +837,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersVariantMentions200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkerVariantMentionsResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_variant_mentions",
+        :operation => :"BiomarkersApi.biomarkers_biomarker_variant_mentions",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -1319,34 +854,34 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_variant_mentions\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_biomarker_variant_mentions\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Vendor sourcing
+    # One biomarker
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersVendorSourcing200Response]
-    def biomarkers_vendor_sourcing(id, opts = {})
-      data, _status_code, _headers = biomarkers_vendor_sourcing_with_http_info(id, opts)
+    # @return [BiomarkersRecord]
+    def biomarkers_get(id, opts = {})
+      data, _status_code, _headers = biomarkers_get_with_http_info(id, opts)
       data
     end
 
-    # Vendor sourcing
+    # One biomarker
     # @param id [String] 
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersVendorSourcing200Response, Integer, Hash)>] BiomarkersVendorSourcing200Response data, response status code and response headers
-    def biomarkers_vendor_sourcing_with_http_info(id, opts = {})
+    # @return [Array<(BiomarkersRecord, Integer, Hash)>] BiomarkersRecord data, response status code and response headers
+    def biomarkers_get_with_http_info(id, opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_vendor_sourcing ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_get ...'
       end
       # verify the required parameter 'id' is set
       if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_vendor_sourcing"
+        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_get"
       end
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/vendor_sourcing'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers/{id}'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
 
       # query parameters
       query_params = opts[:query_params] || {}
@@ -1363,13 +898,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersVendorSourcing200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkersRecord'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_vendor_sourcing",
+        :operation => :"BiomarkersApi.biomarkers_get",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -1380,37 +915,54 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_vendor_sourcing\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_get\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end
 
-    # Where it appears
-    # @param id [String] 
+    # List biomarkers
     # @param [Hash] opts the optional parameters
-    # @return [BiomarkersWhereItAppears200Response]
-    def biomarkers_where_it_appears(id, opts = {})
-      data, _status_code, _headers = biomarkers_where_it_appears_with_http_info(id, opts)
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [BiomarkersResponse]
+    def biomarkers_list(opts = {})
+      data, _status_code, _headers = biomarkers_list_with_http_info(opts)
       data
     end
 
-    # Where it appears
-    # @param id [String] 
+    # List biomarkers
     # @param [Hash] opts the optional parameters
-    # @return [Array<(BiomarkersWhereItAppears200Response, Integer, Hash)>] BiomarkersWhereItAppears200Response data, response status code and response headers
-    def biomarkers_where_it_appears_with_http_info(id, opts = {})
+    # @option opts [String] :cursor The next_cursor of the previous page. Opaque; it is bound to the filters and the warehouse build that issued it.
+    # @option opts [Integer] :limit Rows per page, up to 500 (default 50).
+    # @option opts [String] :sort Comma separated columns, a leading minus for descending: sort&#x3D;a,-b.
+    # @option opts [String] :group_by A dimension to group by; a date takes :year, :quarter or :month.
+    # @option opts [String] :measure count, sum(col), avg(col), min(col), max(col), median(col) or count_distinct(col).
+    # @return [Array<(BiomarkersResponse, Integer, Hash)>] BiomarkersResponse data, response status code and response headers
+    def biomarkers_list_with_http_info(opts = {})
       if @api_client.config.debugging
-        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_where_it_appears ...'
+        @api_client.config.logger.debug 'Calling API: BiomarkersApi.biomarkers_list ...'
       end
-      # verify the required parameter 'id' is set
-      if @api_client.config.client_side_validation && id.nil?
-        fail ArgumentError, "Missing the required parameter 'id' when calling BiomarkersApi.biomarkers_where_it_appears"
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] > 500
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_list, must be smaller than or equal to 500.'
+      end
+
+      if @api_client.config.client_side_validation && !opts[:'limit'].nil? && opts[:'limit'] < 1
+        fail ArgumentError, 'invalid value for "opts[:"limit"]" when calling BiomarkersApi.biomarkers_list, must be greater than or equal to 1.'
       end
+
       # resource path
-      local_var_path = '/api/v1/biomarkers/{id}/where_it_appears'.sub('{' + 'id' + '}', CGI.escape(id.to_s))
+      local_var_path = '/api/v1/biomarkers'
 
       # query parameters
       query_params = opts[:query_params] || {}
+      query_params[:'cursor'] = opts[:'cursor'] if !opts[:'cursor'].nil?
+      query_params[:'limit'] = opts[:'limit'] if !opts[:'limit'].nil?
+      query_params[:'sort'] = opts[:'sort'] if !opts[:'sort'].nil?
+      query_params[:'group_by'] = opts[:'group_by'] if !opts[:'group_by'].nil?
+      query_params[:'measure'] = opts[:'measure'] if !opts[:'measure'].nil?
 
       # header parameters
       header_params = opts[:header_params] || {}
@@ -1424,13 +976,13 @@ module PharmaObservatory
       post_body = opts[:debug_body]
 
       # return_type
-      return_type = opts[:debug_return_type] || 'BiomarkersWhereItAppears200Response'
+      return_type = opts[:debug_return_type] || 'BiomarkersResponse'
 
       # auth_names
       auth_names = opts[:debug_auth_names] || ['ApiBearerJwt']
 
       new_options = opts.merge(
-        :operation => :"BiomarkersApi.biomarkers_where_it_appears",
+        :operation => :"BiomarkersApi.biomarkers_list",
         :header_params => header_params,
         :query_params => query_params,
         :form_params => form_params,
@@ -1441,7 +993,7 @@ module PharmaObservatory
 
       data, status_code, headers = @api_client.call_api(:GET, local_var_path, new_options)
       if @api_client.config.debugging
-        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_where_it_appears\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
+        @api_client.config.logger.debug "API called: BiomarkersApi#biomarkers_list\nData: #{data.inspect}\nStatus code: #{status_code}\nHeaders: #{headers}"
       end
       return data, status_code, headers
     end