heor-agent-mcp 0.1.0

package/dist/providers/types.d.ts

@@ -0,0 +1,176 @@
+import type { AuditRecord } from "../audit/types.js";
+export type OutputFormat = "text" | "json" | "docx";
+export type HtaBody = "nice" | "ema" | "fda" | "iqwig" | "has" | "jca";
+export type SubmissionType = "sta" | "mta" | "early_access" | "initial" | "renewal" | "variation";
+export type DataSource = "pubmed" | "clinicaltrials" | "biorxiv" | "chembl" | "embase" | "who_gho" | "world_bank" | "all_of_us" | "oecd" | "ihme_gbd" | "orange_book" | "purple_book" | "cochrane" | "citeline" | "pharmapendium" | "cortellis" | "google_scholar" | "cms_nadac" | "pssru" | "nhs_costs" | "bnf" | "pbs_schedule" | "datasus" | "conitec" | "anvisa" | "paho" | "iets" | "fonasa" | "hitap" | "nice_ta" | "cadth_reviews" | "icer_reports" | "pbac_psd" | "gba_decisions" | "has_tc" | "iqwig" | "aifa" | "tlv" | "inesss" | "ispor";
+export type StudyType = "rct" | "meta_analysis" | "observational" | "review";
+export type TimeHorizon = "lifetime" | "5yr" | "10yr" | number;
+export type Perspective = "nhs" | "us_payer" | "societal";
+export interface LiteratureResult {
+    id: string;
+    source: DataSource;
+    title: string;
+    authors: string[];
+    date: string;
+    study_type: string;
+    abstract: string;
+    url: string;
+}
+export interface LiteratureSearchParams {
+    query: string;
+    sources?: DataSource[];
+    max_results?: number;
+    date_from?: string;
+    study_types?: StudyType[];
+    output_format?: OutputFormat;
+    project?: string;
+}
+export interface CEModelParams {
+    intervention: string;
+    comparator: string;
+    indication: string;
+    time_horizon: TimeHorizon;
+    perspective: Perspective;
+    clinical_inputs: {
+        efficacy_delta: number;
+        mortality_reduction?: number;
+        ae_rate?: number;
+    };
+    cost_inputs: {
+        drug_cost_annual: number;
+        admin_cost?: number;
+        ae_cost?: number;
+        comparator_cost_annual: number;
+    };
+    utility_inputs?: {
+        qaly_on_treatment: number;
+        qaly_comparator: number;
+    };
+    output_format?: OutputFormat;
+    model_type?: "markov" | "partsa" | "decision_tree";
+    states?: string[];
+    run_psa?: boolean;
+    psa_iterations?: number;
+    run_owsa?: boolean;
+    parameter_uncertainty?: {
+        transition_probabilities?: Record<string, {
+            mean: number;
+            ci_lower: number;
+            ci_upper: number;
+        }>;
+        utilities?: Record<string, {
+            mean: number;
+            ci_lower: number;
+            ci_upper: number;
+        }>;
+        costs?: Record<string, {
+            mean: number;
+            sd: number;
+        }>;
+    };
+    project?: string;
+    survival_inputs?: {
+        os_median_months?: number;
+        pfs_median_months?: number;
+        os_median_months_comparator?: number;
+        pfs_median_months_comparator?: number;
+        survival_distribution?: "exponential" | "weibull";
+        weibull_shape?: number;
+    };
+}
+export interface PicoDefinition {
+    id: string;
+    population: string;
+    comparator: string;
+    outcomes: string[];
+}
+export interface DossierParams {
+    hta_body: HtaBody;
+    submission_type: SubmissionType;
+    drug_name: string;
+    indication: string;
+    evidence_summary?: string | LiteratureResult[];
+    model_results?: CEModelResult;
+    output_format?: OutputFormat;
+    picos?: PicoDefinition[];
+    project?: string;
+}
+export interface ToolResult {
+    content: string | object;
+    audit: AuditRecord;
+}
+export interface WTPAssessment {
+    threshold_low: number;
+    threshold_high: number;
+    currency: string;
+    symbol: string;
+    verdict: "cost_effective" | "borderline" | "not_cost_effective" | "dominated";
+}
+export interface PSASummary {
+    iterations: number;
+    mean_icer: number;
+    ci_icer_lower: number;
+    ci_icer_upper: number;
+    prob_cost_effective: Record<string, number>;
+    ceac: Array<{
+        wtp: number;
+        prob_ce: number;
+    }>;
+    evpi: number;
+    scatter: Array<{
+        delta_cost: number;
+        delta_qaly: number;
+    }>;
+}
+export interface OWSASummary {
+    parameter: string;
+    low_value: number;
+    high_value: number;
+    icer_low: number;
+    icer_high: number;
+    impact: number;
+}
+export interface CEModelResult {
+    base_case: {
+        icer: number;
+        delta_cost: number;
+        delta_qaly: number;
+        incremental_lys: number;
+        total_cost_intervention: number;
+        total_cost_comparator: number;
+        total_qaly_intervention: number;
+        total_qaly_comparator: number;
+    };
+    psa?: PSASummary;
+    owsa?: OWSASummary[];
+    wtp_analysis: {
+        nhs: WTPAssessment;
+        us_payer: WTPAssessment;
+        societal: WTPAssessment;
+    };
+    model_metadata: {
+        model_type: string;
+        states: string[];
+        cycles: number;
+        cycle_length: string;
+        discount_rate_costs: number;
+        discount_rate_outcomes: number;
+        time_horizon_years: number;
+    };
+    audit: AuditRecord;
+}
+export interface DossierSection {
+    name: string;
+    content: string;
+    status: "complete" | "partial" | "missing";
+}
+export interface DossierResult {
+    sections: DossierSection[];
+    gaps: string[];
+}
+export interface IProvider {
+    searchLiterature(params: LiteratureSearchParams): Promise<ToolResult>;
+    buildCEModel(params: CEModelParams): Promise<ToolResult>;
+    prepDossier(params: DossierParams): Promise<ToolResult>;
+}
+//# sourceMappingURL=types.d.ts.map

package/dist/providers/types.d.ts.map

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package/dist/providers/types.js

@@ -0,0 +1,2 @@
+export {};
+//# sourceMappingURL=types.js.map

package/dist/providers/types.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"types.js","sourceRoot":"","sources":["../../src/providers/types.ts"],"names":[],"mappings":""}

package/dist/server.d.ts

@@ -0,0 +1,3 @@
+#!/usr/bin/env node
+export {};
+//# sourceMappingURL=server.d.ts.map

package/dist/server.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"server.d.ts","sourceRoot":"","sources":["../src/server.ts"],"names":[],"mappings":""}

package/dist/server.js

@@ -0,0 +1,80 @@
+#!/usr/bin/env node
+import { Server } from "@modelcontextprotocol/sdk/server/index.js";
+import { StdioServerTransport } from "@modelcontextprotocol/sdk/server/stdio.js";
+import { CallToolRequestSchema, ListToolsRequestSchema, } from "@modelcontextprotocol/sdk/types.js";
+import { handleLiteratureSearch, literatureSearchToolSchema, } from "./tools/literatureSearch.js";
+import { handleCostEffectivenessModel, costEffectivenessModelToolSchema, } from "./tools/costEffectivenessModel.js";
+import { handleHtaDossierPrep, htaDossierPrepToolSchema, } from "./tools/htaDossierPrep.js";
+import { handleKnowledgeSearch, knowledgeSearchToolSchema, } from "./tools/knowledgeSearch.js";
+import { handleKnowledgeRead, knowledgeReadToolSchema, } from "./tools/knowledgeRead.js";
+import { handleKnowledgeWrite, knowledgeWriteToolSchema, } from "./tools/knowledgeWrite.js";
+import { handleProjectCreate, projectCreateToolSchema, } from "./tools/projectCreate.js";
+const server = new Server({ name: "heor-agent-mcp", version: "0.1.0" }, { capabilities: { tools: {} } });
+server.setRequestHandler(ListToolsRequestSchema, async () => ({
+    tools: [
+        literatureSearchToolSchema,
+        costEffectivenessModelToolSchema,
+        htaDossierPrepToolSchema,
+        knowledgeSearchToolSchema,
+        knowledgeReadToolSchema,
+        knowledgeWriteToolSchema,
+        projectCreateToolSchema,
+    ],
+}));
+server.setRequestHandler(CallToolRequestSchema, async (request) => {
+    const { name, arguments: args } = request.params;
+    try {
+        let result;
+        switch (name) {
+            case "literature_search":
+                result = await handleLiteratureSearch(args);
+                break;
+            case "cost_effectiveness_model":
+                result = await handleCostEffectivenessModel(args);
+                break;
+            case "hta_dossier_prep":
+                result = await handleHtaDossierPrep(args);
+                break;
+            case "knowledge_search":
+                result = await handleKnowledgeSearch(args);
+                break;
+            case "knowledge_read":
+                result = await handleKnowledgeRead(args);
+                break;
+            case "knowledge_write":
+                result = await handleKnowledgeWrite(args);
+                break;
+            case "project_create":
+                result = await handleProjectCreate(args);
+                break;
+            default:
+                return {
+                    content: [{ type: "text", text: `Unknown tool: ${name}` }],
+                    isError: true,
+                };
+        }
+        const content = typeof result.content === "string"
+            ? result.content
+            : JSON.stringify(result.content, null, 2);
+        return {
+            content: [{ type: "text", text: content }],
+        };
+    }
+    catch (err) {
+        const message = err instanceof Error ? err.message : String(err);
+        return {
+            content: [{ type: "text", text: `Error: ${message}` }],
+            isError: true,
+        };
+    }
+});
+async function main() {
+    const transport = new StdioServerTransport();
+    await server.connect(transport);
+    console.error("HEORAgent MCP server running on stdio");
+}
+main().catch((err) => {
+    console.error("Fatal error:", err);
+    process.exit(1);
+});
+//# sourceMappingURL=server.js.map

package/dist/server.js.map

@@ -0,0 +1 @@
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package/dist/tools/costEffectivenessModel.d.ts

@@ -0,0 +1,98 @@
+import type { ToolResult } from "../providers/types.js";
+export declare function handleCostEffectivenessModel(rawParams: unknown): Promise<ToolResult>;
+export declare const costEffectivenessModelToolSchema: {
+    name: string;
+    description: string;
+    inputSchema: {
+        type: string;
+        properties: {
+            intervention: {
+                type: string;
+                description: string;
+            };
+            comparator: {
+                type: string;
+                description: string;
+            };
+            indication: {
+                type: string;
+                description: string;
+            };
+            time_horizon: {
+                type: string;
+                description: string;
+            };
+            perspective: {
+                type: string;
+                enum: string[];
+            };
+            model_type: {
+                type: string;
+                enum: string[];
+                description: string;
+            };
+            clinical_inputs: {
+                type: string;
+                properties: {
+                    efficacy_delta: {
+                        type: string;
+                    };
+                    mortality_reduction: {
+                        type: string;
+                    };
+                    ae_rate: {
+                        type: string;
+                    };
+                };
+                required: string[];
+            };
+            cost_inputs: {
+                type: string;
+                properties: {
+                    drug_cost_annual: {
+                        type: string;
+                    };
+                    admin_cost: {
+                        type: string;
+                    };
+                    ae_cost: {
+                        type: string;
+                    };
+                    comparator_cost_annual: {
+                        type: string;
+                    };
+                };
+                required: string[];
+            };
+            utility_inputs: {
+                type: string;
+                properties: {
+                    qaly_on_treatment: {
+                        type: string;
+                    };
+                    qaly_comparator: {
+                        type: string;
+                    };
+                };
+            };
+            run_psa: {
+                type: string;
+                description: string;
+            };
+            psa_iterations: {
+                type: string;
+                description: string;
+            };
+            output_format: {
+                type: string;
+                enum: string[];
+            };
+            project: {
+                type: string;
+                description: string;
+            };
+        };
+        required: string[];
+    };
+};
+//# sourceMappingURL=costEffectivenessModel.d.ts.map

package/dist/tools/costEffectivenessModel.d.ts.map

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