heor-agent-mcp 0.1.0

package/dist/providers/direct/fonasa.js

@@ -0,0 +1,25 @@
+export async function fetchFonasa(query, maxResults) {
+    const entries = [
+        {
+            title: `FONASA Chile Statistics: ${query}`,
+            abstract: `FONASA (Fondo Nacional de Salud) is Chile's public health insurance covering ~80% of population. Statistical bulletins cover enrollment, utilization (outpatient, inpatient, emergency, pharmacy), and expenditure. Essential for Chilean HEOR and burden-of-illness studies.`,
+            url: `https://www.fonasa.cl/sites/fonasa/institucional/estadisticas`,
+        },
+        {
+            title: `DEIS Chile Epidemiological Data`,
+            abstract: `DEIS (Departamento de Estadísticas e Información de Salud, Ministry of Health Chile) publishes mortality, morbidity, and health resource data. Complements FONASA data for Chilean epidemiological inputs.`,
+            url: "https://deis.minsal.cl/",
+        },
+    ];
+    return entries.slice(0, maxResults).map((e, i) => ({
+        id: `fonasa_${i}`,
+        source: "fonasa",
+        title: e.title,
+        authors: ["FONASA — Ministerio de Salud de Chile"],
+        date: new Date().getFullYear().toString(),
+        study_type: "registry",
+        abstract: e.abstract,
+        url: e.url,
+    }));
+}
+//# sourceMappingURL=fonasa.js.map

package/dist/providers/direct/fonasa.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"fonasa.js","sourceRoot":"","sources":["../../../src/providers/direct/fonasa.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,WAAW,CAAC,KAAa,EAAE,UAAkB;IACjE,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,4BAA4B,KAAK,EAAE;YAC1C,QAAQ,EAAE,+QAA+Q;YACzR,GAAG,EAAE,+DAA+D;SACrE;QACD;YACE,KAAK,EAAE,iCAAiC;YACxC,QAAQ,EAAE,4MAA4M;YACtN,GAAG,EAAE,yBAAyB;SAC/B;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,UAAU,CAAC,EAAE;QACjB,MAAM,EAAE,QAAiB;QACzB,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE,CAAC,uCAAuC,CAAC;QAClD,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,UAAU;QACtB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}

package/dist/providers/direct/gbaDecisions.d.ts

@@ -0,0 +1,3 @@
+import type { LiteratureResult } from "../types.js";
+export declare function fetchGbaDecisions(query: string, maxResults: number): Promise<LiteratureResult[]>;
+//# sourceMappingURL=gbaDecisions.d.ts.map

package/dist/providers/direct/gbaDecisions.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"gbaDecisions.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/gbaDecisions.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,iBAAiB,CAAC,KAAK,EAAE,MAAM,EAAE,UAAU,EAAE,MAAM,GAAG,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA6BtG"}

package/dist/providers/direct/gbaDecisions.js

@@ -0,0 +1,30 @@
+export async function fetchGbaDecisions(query, maxResults) {
+    const entries = [
+        {
+            title: `G-BA Benefit Assessment Search: ${query}`,
+            abstract: `G-BA (Gemeinsamer Bundesausschuss — Federal Joint Committee) conducts early benefit assessments of new medicines under the AMNOG process in Germany. Each assessment determines added benefit vs. the appropriate comparator therapy, which directly influences price negotiations with GKV-Spitzenverband. Search "${query}" to find G-BA decisions relevant to the drug or indication. Critical for German market access and pricing strategy.`,
+            url: `https://www.g-ba.de/bewertungsverfahren/nutzenbewertung/?from=${encodeURIComponent(query)}`,
+        },
+        {
+            title: `G-BA AMNOG Process Guide`,
+            abstract: `AMNOG (Arzneimittelmarktneuordnungsgesetz) is Germany's early benefit assessment process requiring manufacturers to submit dossiers within 3 months of launch. G-BA assesses added benefit in up to 6 months; IQWiG may conduct the assessment. Outcome determines negotiated price or arbitration. Key reference for planning German market access strategy.`,
+            url: "https://www.g-ba.de/english/",
+        },
+        {
+            title: `IQWiG Dossier Assessments`,
+            abstract: `IQWiG (Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen) conducts dossier assessments commissioned by G-BA under AMNOG. IQWiG reviews the manufacturer's evidence dossier and issues a preliminary assessment of added benefit. Archive of published assessments is searchable by drug name and indication.`,
+            url: "https://www.iqwig.de/en/projects/?tab=dossier-assessments",
+        },
+    ];
+    return entries.slice(0, maxResults).map((e, i) => ({
+        id: `gba_decisions_${i}`,
+        source: "gba_decisions",
+        title: e.title,
+        authors: ["Gemeinsamer Bundesausschuss (G-BA) — Federal Joint Committee, Germany"],
+        date: new Date().getFullYear().toString(),
+        study_type: "hta_report",
+        abstract: e.abstract,
+        url: e.url,
+    }));
+}
+//# sourceMappingURL=gbaDecisions.js.map

package/dist/providers/direct/gbaDecisions.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"gbaDecisions.js","sourceRoot":"","sources":["../../../src/providers/direct/gbaDecisions.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,iBAAiB,CAAC,KAAa,EAAE,UAAkB;IACvE,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,mCAAmC,KAAK,EAAE;YACjD,QAAQ,EAAE,uTAAuT,KAAK,sHAAsH;YAC5b,GAAG,EAAE,iEAAiE,kBAAkB,CAAC,KAAK,CAAC,EAAE;SAClG;QACD;YACE,KAAK,EAAE,0BAA0B;YACjC,QAAQ,EAAE,+VAA+V;YACzW,GAAG,EAAE,8BAA8B;SACpC;QACD;YACE,KAAK,EAAE,2BAA2B;YAClC,QAAQ,EAAE,6TAA6T;YACvU,GAAG,EAAE,2DAA2D;SACjE;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,iBAAiB,CAAC,EAAE;QACxB,MAAM,EAAE,eAAwB;QAChC,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE,CAAC,uEAAuE,CAAC;QAClF,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}

package/dist/providers/direct/googleScholar.d.ts

@@ -0,0 +1,3 @@
+import type { LiteratureResult } from "../types.js";
+export declare function fetchGoogleScholar(query: string, maxResults: number): Promise<LiteratureResult[]>;
+//# sourceMappingURL=googleScholar.d.ts.map

package/dist/providers/direct/googleScholar.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"googleScholar.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/googleScholar.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAkBpD,wBAAsB,kBAAkB,CACtC,KAAK,EAAE,MAAM,EACb,UAAU,EAAE,MAAM,GACjB,OAAO,CAAC,gBAAgB,EAAE,CAAC,CAkC7B"}

package/dist/providers/direct/googleScholar.js

@@ -0,0 +1,39 @@
+const BASE = "https://serpapi.com/search";
+export async function fetchGoogleScholar(query, maxResults) {
+    const apiKey = process.env.SERPAPI_KEY;
+    if (!apiKey)
+        return [];
+    try {
+        const url = `${BASE}?engine=google_scholar&q=${encodeURIComponent(query)}&num=${Math.min(maxResults, 20)}&api_key=${apiKey}`;
+        const res = await fetch(url);
+        if (!res.ok)
+            return [];
+        const data = (await res.json());
+        if (data.error || !data.organic_results)
+            return [];
+        return data.organic_results.slice(0, maxResults).map((r, i) => {
+            const authors = r.publication_info?.authors?.map(a => a.name) ?? [];
+            const pubSummary = r.publication_info?.summary ?? "";
+            // pub summary often: "A Smith, B Jones - Journal Name, 2023 - publisher.com"
+            const yearMatch = pubSummary.match(/\b(19|20)\d{2}\b/);
+            return {
+                id: `gscholar_${r.result_id ?? i}`,
+                source: "google_scholar",
+                title: r.title ?? "Untitled",
+                authors,
+                date: yearMatch ? yearMatch[0] : "",
+                study_type: "unknown",
+                abstract: [
+                    r.snippet ?? "",
+                    pubSummary ? `Publication: ${pubSummary}` : null,
+                    r.inline_links?.cited_by?.total ? `Cited by: ${r.inline_links.cited_by.total}` : null,
+                ].filter(Boolean).join(" | "),
+                url: r.link ?? "",
+            };
+        });
+    }
+    catch {
+        return [];
+    }
+}
+//# sourceMappingURL=googleScholar.js.map

package/dist/providers/direct/googleScholar.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"googleScholar.js","sourceRoot":"","sources":["../../../src/providers/direct/googleScholar.ts"],"names":[],"mappings":"AAEA,MAAM,IAAI,GAAG,4BAA4B,CAAC;AAgB1C,MAAM,CAAC,KAAK,UAAU,kBAAkB,CACtC,KAAa,EACb,UAAkB;IAElB,MAAM,MAAM,GAAG,OAAO,CAAC,GAAG,CAAC,WAAW,CAAC;IACvC,IAAI,CAAC,MAAM;QAAE,OAAO,EAAE,CAAC;IAEvB,IAAI,CAAC;QACH,MAAM,GAAG,GAAG,GAAG,IAAI,4BAA4B,kBAAkB,CAAC,KAAK,CAAC,QAAQ,IAAI,CAAC,GAAG,CAAC,UAAU,EAAE,EAAE,CAAC,YAAY,MAAM,EAAE,CAAC;QAC7H,MAAM,GAAG,GAAG,MAAM,KAAK,CAAC,GAAG,CAAC,CAAC;QAC7B,IAAI,CAAC,GAAG,CAAC,EAAE;YAAE,OAAO,EAAE,CAAC;QACvB,MAAM,IAAI,GAAG,CAAC,MAAM,GAAG,CAAC,IAAI,EAAE,CAAoB,CAAC;QACnD,IAAI,IAAI,CAAC,KAAK,IAAI,CAAC,IAAI,CAAC,eAAe;YAAE,OAAO,EAAE,CAAC;QAEnD,OAAO,IAAI,CAAC,eAAe,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE;YAC5D,MAAM,OAAO,GAAG,CAAC,CAAC,gBAAgB,EAAE,OAAO,EAAE,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,IAAI,CAAC,IAAI,EAAE,CAAC;YACpE,MAAM,UAAU,GAAG,CAAC,CAAC,gBAAgB,EAAE,OAAO,IAAI,EAAE,CAAC;YACrD,6EAA6E;YAC7E,MAAM,SAAS,GAAG,UAAU,CAAC,KAAK,CAAC,kBAAkB,CAAC,CAAC;YACvD,OAAO;gBACL,EAAE,EAAE,YAAY,CAAC,CAAC,SAAS,IAAI,CAAC,EAAE;gBAClC,MAAM,EAAE,gBAAyB;gBACjC,KAAK,EAAE,CAAC,CAAC,KAAK,IAAI,UAAU;gBAC5B,OAAO;gBACP,IAAI,EAAE,SAAS,CAAC,CAAC,CAAC,SAAS,CAAC,CAAC,CAAC,CAAC,CAAC,CAAC,EAAE;gBACnC,UAAU,EAAE,SAAS;gBACrB,QAAQ,EAAE;oBACR,CAAC,CAAC,OAAO,IAAI,EAAE;oBACf,UAAU,CAAC,CAAC,CAAC,gBAAgB,UAAU,EAAE,CAAC,CAAC,CAAC,IAAI;oBAChD,CAAC,CAAC,YAAY,EAAE,QAAQ,EAAE,KAAK,CAAC,CAAC,CAAC,aAAa,CAAC,CAAC,YAAY,CAAC,QAAQ,CAAC,KAAK,EAAE,CAAC,CAAC,CAAC,IAAI;iBACtF,CAAC,MAAM,CAAC,OAAO,CAAC,CAAC,IAAI,CAAC,KAAK,CAAC;gBAC7B,GAAG,EAAE,CAAC,CAAC,IAAI,IAAI,EAAE;aAClB,CAAC;QACJ,CAAC,CAAC,CAAC;IACL,CAAC;IAAC,MAAM,CAAC;QACP,OAAO,EAAE,CAAC;IACZ,CAAC;AACH,CAAC"}

package/dist/providers/direct/hasTc.d.ts

@@ -0,0 +1,3 @@
+import type { LiteratureResult } from "../types.js";
+export declare function fetchHasTc(query: string, maxResults: number): Promise<LiteratureResult[]>;
+//# sourceMappingURL=hasTc.d.ts.map

package/dist/providers/direct/hasTc.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"hasTc.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/hasTc.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,UAAU,CAAC,KAAK,EAAE,MAAM,EAAE,UAAU,EAAE,MAAM,GAAG,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA6B/F"}

package/dist/providers/direct/hasTc.js

@@ -0,0 +1,30 @@
+export async function fetchHasTc(query, maxResults) {
+    const entries = [
+        {
+            title: `HAS Transparency Committee Opinions: ${query}`,
+            abstract: `HAS (Haute Autorité de Santé) Transparency Committee evaluates medicines for reimbursement in France. Each opinion assigns SMR (Service Médical Rendu — medical benefit level) and ASMR (Amélioration du Service Médical Rendu — improvement in medical benefit, rated I–V) ratings. ASMR rating directly affects the negotiated price with CEPS. Search "${query}" to find CT opinions relevant to the drug or indication. Critical for French market access strategy.`,
+            url: `https://www.has-sante.fr/jcms/fc_2875208/en/transparency-committee?text=${encodeURIComponent(query)}`,
+        },
+        {
+            title: `HAS Methodology Guide for Economic Evaluation (2020)`,
+            abstract: `HAS's reference guide for economic evaluations submitted to support reimbursement and pricing decisions in France. Covers study design, perspective (collective), discount rates (4%), comparator selection, QALY methodology, and willingness-to-pay thresholds. Required reading for French HTA dossier preparation.`,
+            url: "https://www.has-sante.fr/jcms/r_1499251/en/choices-in-methods-for-economic-evaluation",
+        },
+        {
+            title: `CEPS Drug Pricing Framework (France)`,
+            abstract: `CEPS (Comité Économique des Produits de Santé) negotiates drug prices with manufacturers based on HAS Transparency Committee ASMR ratings. Drugs with ASMR I–III receive premium pricing; ASMR IV/V are priced at or below comparators. Reference for understanding French pricing framework and negotiation leverage.`,
+            url: "https://solidarites-sante.gouv.fr/ministere/acteurs/instances-rattachees/comite-economique-des-produits-de-sante-ceps/",
+        },
+    ];
+    return entries.slice(0, maxResults).map((e, i) => ({
+        id: `has_tc_${i}`,
+        source: "has_tc",
+        title: e.title,
+        authors: ["Haute Autorité de Santé (HAS) — French National Authority for Health"],
+        date: new Date().getFullYear().toString(),
+        study_type: "hta_report",
+        abstract: e.abstract,
+        url: e.url,
+    }));
+}
+//# sourceMappingURL=hasTc.js.map

package/dist/providers/direct/hasTc.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"hasTc.js","sourceRoot":"","sources":["../../../src/providers/direct/hasTc.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,UAAU,CAAC,KAAa,EAAE,UAAkB;IAChE,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,wCAAwC,KAAK,EAAE;YACtD,QAAQ,EAAE,6VAA6V,KAAK,uGAAuG;YACnd,GAAG,EAAE,2EAA2E,kBAAkB,CAAC,KAAK,CAAC,EAAE;SAC5G;QACD;YACE,KAAK,EAAE,sDAAsD;YAC7D,QAAQ,EAAE,wTAAwT;YAClU,GAAG,EAAE,uFAAuF;SAC7F;QACD;YACE,KAAK,EAAE,sCAAsC;YAC7C,QAAQ,EAAE,wTAAwT;YAClU,GAAG,EAAE,wHAAwH;SAC9H;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,UAAU,CAAC,EAAE;QACjB,MAAM,EAAE,QAAiB;QACzB,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE,CAAC,sEAAsE,CAAC;QACjF,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}

package/dist/providers/direct/hitap.d.ts

@@ -0,0 +1,3 @@
+import type { LiteratureResult } from "../types.js";
+export declare function fetchHitap(query: string, maxResults: number): Promise<LiteratureResult[]>;
+//# sourceMappingURL=hitap.d.ts.map

package/dist/providers/direct/hitap.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"hitap.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/hitap.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,UAAU,CAAC,KAAK,EAAE,MAAM,EAAE,UAAU,EAAE,MAAM,GAAG,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA6B/F"}

package/dist/providers/direct/hitap.js

@@ -0,0 +1,30 @@
+export async function fetchHitap(query, maxResults) {
+    const entries = [
+        {
+            title: `HITAP Thailand HTA Database: ${query}`,
+            abstract: `HITAP (Health Intervention and Technology Assessment Program) is Thailand's HTA agency and a regional APAC leader. Publishes cost-effectiveness analyses, budget impact studies, and policy briefs. Reports in Thai and English. Key resource for APAC HTA methodology and precedents.`,
+            url: `https://www.hitap.net/en/?s=${encodeURIComponent(query)}`,
+        },
+        {
+            title: `HITAP Reference Case (Thai Working Group on HTA)`,
+            abstract: `Thailand's reference case methodology for economic evaluation, similar to NICE reference case. Covers perspective, time horizon, discount rate (3% for Thailand), utility measurement, and uncertainty analysis. Standard for Thai CE model submissions.`,
+            url: "https://www.hitap.net/en/research/reference-case",
+        },
+        {
+            title: `iDSI International Decision Support Initiative`,
+            abstract: `HITAP co-leads iDSI — a global network supporting HTA capacity in LMICs. Useful for understanding APAC/LATAM/Africa HTA methodology harmonization and finding regional HEOR collaborators.`,
+            url: "https://idsihealth.org/",
+        },
+    ];
+    return entries.slice(0, maxResults).map((e, i) => ({
+        id: `hitap_${i}`,
+        source: "hitap",
+        title: e.title,
+        authors: ["HITAP — Health Intervention and Technology Assessment Program (Thailand)"],
+        date: new Date().getFullYear().toString(),
+        study_type: "hta_report",
+        abstract: e.abstract,
+        url: e.url,
+    }));
+}
+//# sourceMappingURL=hitap.js.map

package/dist/providers/direct/hitap.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"hitap.js","sourceRoot":"","sources":["../../../src/providers/direct/hitap.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,UAAU,CAAC,KAAa,EAAE,UAAkB;IAChE,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,gCAAgC,KAAK,EAAE;YAC9C,QAAQ,EAAE,wRAAwR;YAClS,GAAG,EAAE,+BAA+B,kBAAkB,CAAC,KAAK,CAAC,EAAE;SAChE;QACD;YACE,KAAK,EAAE,kDAAkD;YACzD,QAAQ,EAAE,0PAA0P;YACpQ,GAAG,EAAE,kDAAkD;SACxD;QACD;YACE,KAAK,EAAE,gDAAgD;YACvD,QAAQ,EAAE,4LAA4L;YACtM,GAAG,EAAE,yBAAyB;SAC/B;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,SAAS,CAAC,EAAE;QAChB,MAAM,EAAE,OAAgB;QACxB,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE,CAAC,0EAA0E,CAAC;QACrF,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}

package/dist/providers/direct/icerReports.d.ts

@@ -0,0 +1,3 @@
+import type { LiteratureResult } from "../types.js";
+export declare function fetchIcerReports(query: string, maxResults: number): Promise<LiteratureResult[]>;
+//# sourceMappingURL=icerReports.d.ts.map

package/dist/providers/direct/icerReports.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"icerReports.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/icerReports.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,gBAAgB,CAAC,KAAK,EAAE,MAAM,EAAE,UAAU,EAAE,MAAM,GAAG,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA6BrG"}

package/dist/providers/direct/icerReports.js

@@ -0,0 +1,30 @@
+export async function fetchIcerReports(query, maxResults) {
+    const entries = [
+        {
+            title: `ICER Evidence Report: ${query}`,
+            abstract: `ICER (Institute for Clinical and Economic Review) produces independent evidence reports assessing the clinical and economic value of new drugs and technologies in the US market. Reports include systematic literature reviews, cost-effectiveness analyses, and health-benefit price benchmarks (HBPBs). Search "${query}" to find ICER assessments relevant to the drug or indication. Key for US payer negotiations and value-based contract strategy.`,
+            url: `https://icer.org/?s=${encodeURIComponent(query)}`,
+        },
+        {
+            title: `ICER Value Assessment Framework 2023`,
+            abstract: `ICER's Value Assessment Framework describes the methods used in all ICER evidence reports. Covers clinical benefit rating, comparative value rating, incremental cost-effectiveness ratios, health-benefit price benchmarks, and budget impact analysis. Essential reading for understanding ICER's standards and preparing for ICER engagement.`,
+            url: "https://icer.org/our-approach/methods-process/value-assessment-framework/",
+        },
+        {
+            title: `ICER Health-Benefit Price Benchmarks (HBPB)`,
+            abstract: `ICER publishes health-benefit price benchmarks for drugs under review, representing the price at which the drug would achieve acceptable cost-effectiveness at $50K, $100K, and $150K/QALY thresholds. HBPBs are widely referenced in US payer negotiations and value-based contracts. Archive of benchmarks available for previously reviewed drugs.`,
+            url: "https://icer.org/our-approach/methods-process/value-based-price-benchmarks/",
+        },
+    ];
+    return entries.slice(0, maxResults).map((e, i) => ({
+        id: `icer_reports_${i}`,
+        source: "icer_reports",
+        title: e.title,
+        authors: ["Institute for Clinical and Economic Review (ICER)"],
+        date: new Date().getFullYear().toString(),
+        study_type: "hta_report",
+        abstract: e.abstract,
+        url: e.url,
+    }));
+}
+//# sourceMappingURL=icerReports.js.map

package/dist/providers/direct/icerReports.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"icerReports.js","sourceRoot":"","sources":["../../../src/providers/direct/icerReports.ts"],"names":[],"mappings":"AAEA,MAAM,CAAC,KAAK,UAAU,gBAAgB,CAAC,KAAa,EAAE,UAAkB;IACtE,MAAM,OAAO,GAAG;QACd;YACE,KAAK,EAAE,yBAAyB,KAAK,EAAE;YACvC,QAAQ,EAAE,sTAAsT,KAAK,iIAAiI;YACtc,GAAG,EAAE,uBAAuB,kBAAkB,CAAC,KAAK,CAAC,EAAE;SACxD;QACD;YACE,KAAK,EAAE,sCAAsC;YAC7C,QAAQ,EAAE,kVAAkV;YAC5V,GAAG,EAAE,2EAA2E;SACjF;QACD;YACE,KAAK,EAAE,6CAA6C;YACpD,QAAQ,EAAE,uVAAuV;YACjW,GAAG,EAAE,6EAA6E;SACnF;KACF,CAAC;IAEF,OAAO,OAAO,CAAC,KAAK,CAAC,CAAC,EAAE,UAAU,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC,CAAC;QACjD,EAAE,EAAE,gBAAgB,CAAC,EAAE;QACvB,MAAM,EAAE,cAAuB;QAC/B,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,OAAO,EAAE,CAAC,mDAAmD,CAAC;QAC9D,IAAI,EAAE,IAAI,IAAI,EAAE,CAAC,WAAW,EAAE,CAAC,QAAQ,EAAE;QACzC,UAAU,EAAE,YAAY;QACxB,QAAQ,EAAE,CAAC,CAAC,QAAQ;QACpB,GAAG,EAAE,CAAC,CAAC,GAAG;KACX,CAAC,CAAC,CAAC;AACN,CAAC"}

package/dist/providers/direct/iets.d.ts

@@ -0,0 +1,3 @@
+import type { LiteratureResult } from "../types.js";
+export declare function fetchIets(query: string, maxResults: number): Promise<LiteratureResult[]>;
+//# sourceMappingURL=iets.d.ts.map

package/dist/providers/direct/iets.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"iets.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/iets.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAEpD,wBAAsB,SAAS,CAAC,KAAK,EAAE,MAAM,EAAE,UAAU,EAAE,MAAM,GAAG,OAAO,CAAC,gBAAgB,EAAE,CAAC,CAwB9F"}

package/dist/providers/direct/iets.js

@@ -0,0 +1,25 @@
+export async function fetchIets(query, maxResults) {
+    const entries = [
+        {
+            title: `IETS Colombia HTA Reports: ${query}`,
+            abstract: `IETS (Instituto de Evaluación Tecnológica en Salud) is Colombia's HTA agency. Publishes rapid HTAs, full HTAs, and cost-effectiveness analyses for Colombian public health system (POS). Reports in Spanish. Key resource for Andean region HTA precedents.`,
+            url: `https://www.iets.org.co/Paginas/busqueda.aspx?k=${encodeURIComponent(query)}`,
+        },
+        {
+            title: `IETS Methodology Manuals`,
+            abstract: `Colombian HTA methodology manuals covering economic evaluation, systematic reviews, and budget impact analyses. Required reading for Colombia-specific HEOR submissions.`,
+            url: "https://www.iets.org.co/Paginas/publicaciones.aspx",
+        },
+    ];
+    return entries.slice(0, maxResults).map((e, i) => ({
+        id: `iets_${i}`,
+        source: "iets",
+        title: e.title,
+        authors: ["IETS — Instituto de Evaluación Tecnológica en Salud (Colombia)"],
+        date: new Date().getFullYear().toString(),
+        study_type: "hta_report",
+        abstract: e.abstract,
+        url: e.url,
+    }));
+}
+//# sourceMappingURL=iets.js.map

package/dist/providers/direct/iets.js.map

@@ -0,0 +1 @@
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package/dist/providers/direct/ihmeGbd.d.ts

@@ -0,0 +1,3 @@
+import type { LiteratureResult } from "../types.js";
+export declare function fetchIhmeGbd(query: string, maxResults: number): Promise<LiteratureResult[]>;
+//# sourceMappingURL=ihmeGbd.d.ts.map

package/dist/providers/direct/ihmeGbd.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"ihmeGbd.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/ihmeGbd.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EAAE,gBAAgB,EAAE,MAAM,aAAa,CAAC;AAsCpD,wBAAsB,YAAY,CAChC,KAAK,EAAE,MAAM,EACb,UAAU,EAAE,MAAM,GACjB,OAAO,CAAC,gBAAgB,EAAE,CAAC,CA6C7B"}

package/dist/providers/direct/ihmeGbd.js

@@ -0,0 +1,74 @@
+// GBD doesn't have a clean REST API — provide structured reference results
+// pointing users to the right GBD tools
+function getFallbackGbdResults(query, maxResults) {
+    const gbd_tools = [
+        {
+            title: `GBD Results Tool — ${query}`,
+            abstract: `Search the Global Burden of Disease interactive results tool for DALYs, YLLs, YLDs, prevalence, incidence, and mortality estimates related to "${query}". Filter by location, age, sex, year (1990-2021). Data available for 369 diseases and injuries across 204 countries.`,
+            url: `https://vizhub.healthdata.org/gbd-results/?params=gbd-api-2021-permalink/${encodeURIComponent(query)}`,
+        },
+        {
+            title: `GBD Compare Visualization — ${query}`,
+            abstract: `Interactive treemap and heatmap visualization of disease burden for "${query}". Compare across countries, ages, and time periods. Includes DALYs, deaths, prevalence.`,
+            url: `https://vizhub.healthdata.org/gbd-compare/`,
+        },
+        {
+            title: `Global Health Data Exchange — ${query}`,
+            abstract: `Search the IHME Global Health Data Exchange catalog for datasets, surveys, and data sources related to "${query}". Includes census data, survey microdata, and vital registration.`,
+            url: `https://ghdx.healthdata.org/keyword/${encodeURIComponent(query)}`,
+        },
+    ];
+    return gbd_tools.slice(0, maxResults).map((tool, i) => ({
+        id: `ihme_gbd_${i}`,
+        source: "ihme_gbd",
+        title: tool.title,
+        authors: ["Institute for Health Metrics and Evaluation (IHME)"],
+        date: "2024",
+        study_type: "registry",
+        abstract: tool.abstract,
+        url: tool.url,
+    }));
+}
+export async function fetchIhmeGbd(query, maxResults) {
+    try {
+        // Use the GHDx search API for GBD-related records
+        const url = `https://ghdx.healthdata.org/search/site/${encodeURIComponent(query)}?f[0]=field_record_type%3A3&json=true`;
+        const res = await fetch(url, {
+            headers: { Accept: "application/json" },
+        });
+        // If the search API doesn't return JSON, fall back to providing reference links
+        if (!res.ok) {
+            return getFallbackGbdResults(query, maxResults);
+        }
+        const text = await res.text();
+        // Try to parse as JSON
+        try {
+            const data = JSON.parse(text);
+            if (data.results && Array.isArray(data.results)) {
+                return data.results
+                    .slice(0, maxResults)
+                    .map((r, i) => ({
+                    id: `ihme_gbd_${i}`,
+                    source: "ihme_gbd",
+                    title: r.title ?? `GBD Result: ${query}`,
+                    authors: ["Institute for Health Metrics and Evaluation"],
+                    date: r.year ?? new Date().getFullYear().toString(),
+                    study_type: "registry",
+                    abstract: r.snippet ??
+                        r.description ??
+                        `Global Burden of Disease estimate for: ${query}`,
+                    url: r.link ??
+                        `https://vizhub.healthdata.org/gbd-results/`,
+                }));
+            }
+        }
+        catch {
+            // Not JSON, use fallback
+        }
+        return getFallbackGbdResults(query, maxResults);
+    }
+    catch {
+        return getFallbackGbdResults(query, maxResults);
+    }
+}
+//# sourceMappingURL=ihmeGbd.js.map

package/dist/providers/direct/ihmeGbd.js.map

@@ -0,0 +1 @@
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package/dist/providers/direct/index.d.ts

@@ -0,0 +1,7 @@
+import type { IProvider, LiteratureSearchParams, CEModelParams, DossierParams, ToolResult } from "../types.js";
+export declare class DirectProvider implements IProvider {
+    searchLiterature(params: LiteratureSearchParams): Promise<ToolResult>;
+    buildCEModel(_params: CEModelParams): Promise<ToolResult>;
+    prepDossier(_params: DossierParams): Promise<ToolResult>;
+}
+//# sourceMappingURL=index.d.ts.map

package/dist/providers/direct/index.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../../src/providers/direct/index.ts"],"names":[],"mappings":"AAAA,OAAO,KAAK,EACV,SAAS,EACT,sBAAsB,EACtB,aAAa,EACb,aAAa,EACb,UAAU,EAGX,MAAM,aAAa,CAAC;AA6GrB,qBAAa,cAAe,YAAW,SAAS;IACxC,gBAAgB,CAAC,MAAM,EAAE,sBAAsB,GAAG,OAAO,CAAC,UAAU,CAAC;IAuGrE,YAAY,CAAC,OAAO,EAAE,aAAa,GAAG,OAAO,CAAC,UAAU,CAAC;IAMzD,WAAW,CAAC,OAAO,EAAE,aAAa,GAAG,OAAO,CAAC,UAAU,CAAC;CAK/D"}

package/dist/providers/direct/index.js

@@ -0,0 +1,186 @@
+import { saveLiteratureResult } from "../../knowledge/index.js";
+import { createAuditRecord, addSource, addWarning, addAssumption, setMethodology, } from "../../audit/builder.js";
+import { fetchPubMed } from "./pubmed.js";
+import { fetchClinicalTrials } from "./clinicalTrials.js";
+import { fetchBiorxiv } from "./biorxiv.js";
+import { fetchChembl } from "./chembl.js";
+import { fetchEmbase } from "./embase.js";
+import { fetchWhoGho } from "./whoGho.js";
+import { fetchWorldBank } from "./worldBank.js";
+import { fetchAllOfUs } from "./allOfUs.js";
+import { fetchOecd } from "./oecd.js";
+import { fetchIhmeGbd } from "./ihmeGbd.js";
+import { fetchOrangeBook } from "./orangeBook.js";
+import { fetchPurpleBook } from "./purpleBook.js";
+import { fetchCochrane } from "./cochrane.js";
+import { fetchCiteline } from "./citeline.js";
+import { fetchPharmapendium } from "./pharmapendium.js";
+import { fetchCortellis } from "./cortellis.js";
+import { fetchGoogleScholar } from "./googleScholar.js";
+import { fetchCmsNadac } from "./cmsNadac.js";
+import { fetchPssru } from "./pssru.js";
+import { fetchNhsCosts } from "./nhsCosts.js";
+import { fetchBnf } from "./bnf.js";
+import { fetchPbsSchedule } from "./pbsSchedule.js";
+import { fetchDatasus } from "./datasus.js";
+import { fetchConitec } from "./conitec.js";
+import { fetchAnvisa } from "./anvisa.js";
+import { fetchPaho } from "./paho.js";
+import { fetchIets } from "./iets.js";
+import { fetchFonasa } from "./fonasa.js";
+import { fetchHitap } from "./hitap.js";
+import { fetchNiceTa } from "./niceTa.js";
+import { fetchCadthReviews } from "./cadthReviews.js";
+import { fetchIcerReports } from "./icerReports.js";
+import { fetchPbacPsd } from "./pbacPsd.js";
+import { fetchGbaDecisions } from "./gbaDecisions.js";
+import { fetchHasTc } from "./hasTc.js";
+import { fetchIqwig } from "./iqwig.js";
+import { fetchAifa } from "./aifa.js";
+import { fetchTlv } from "./tlv.js";
+import { fetchInesss } from "./inesss.js";
+import { fetchIspor } from "./ispor.js";
+import { getProxyUrl } from "./proxyClient.js";
+import { resultsToMarkdown } from "../../formatters/markdown.js";
+import { resultsToDocx } from "../../formatters/docx.js";
+import { analyzeMetabolicProfile, profileToMarkdown, } from "../../tools/metabolicProfile.js";
+function getAllSources() {
+    const base = ["pubmed", "clinicaltrials", "biorxiv", "chembl"];
+    if (process.env.ELSEVIER_API_KEY)
+        base.push("embase");
+    return base;
+}
+const FETCHERS = {
+    pubmed: fetchPubMed,
+    clinicaltrials: fetchClinicalTrials,
+    biorxiv: fetchBiorxiv,
+    chembl: fetchChembl,
+    embase: fetchEmbase,
+    who_gho: fetchWhoGho,
+    world_bank: fetchWorldBank,
+    all_of_us: fetchAllOfUs,
+    oecd: fetchOecd,
+    ihme_gbd: fetchIhmeGbd,
+    orange_book: fetchOrangeBook,
+    purple_book: fetchPurpleBook,
+    cochrane: fetchCochrane,
+    citeline: fetchCiteline,
+    pharmapendium: fetchPharmapendium,
+    cortellis: fetchCortellis,
+    google_scholar: fetchGoogleScholar,
+    cms_nadac: fetchCmsNadac,
+    pssru: fetchPssru,
+    nhs_costs: fetchNhsCosts,
+    bnf: fetchBnf,
+    pbs_schedule: fetchPbsSchedule,
+    datasus: fetchDatasus,
+    conitec: fetchConitec,
+    anvisa: fetchAnvisa,
+    paho: fetchPaho,
+    iets: fetchIets,
+    fonasa: fetchFonasa,
+    hitap: fetchHitap,
+    nice_ta: fetchNiceTa,
+    cadth_reviews: fetchCadthReviews,
+    icer_reports: fetchIcerReports,
+    pbac_psd: fetchPbacPsd,
+    gba_decisions: fetchGbaDecisions,
+    has_tc: fetchHasTc,
+    iqwig: fetchIqwig,
+    aifa: fetchAifa,
+    tlv: fetchTlv,
+    inesss: fetchInesss,
+    ispor: fetchIspor,
+};
+export class DirectProvider {
+    async searchLiterature(params) {
+        const sources = params.sources ?? getAllSources();
+        const maxPerSource = Math.ceil((params.max_results ?? 20) / sources.length);
+        const outputFormat = params.output_format ?? "text";
+        let audit = createAuditRecord("literature_search", params, outputFormat);
+        audit = setMethodology(audit, "PRISMA-style multi-database search");
+        const proxyActive = getProxyUrl() !== null;
+        const enterpriseKeys = {
+            embase: "ELSEVIER_API_KEY",
+            cochrane: "COCHRANE_API_KEY",
+            citeline: "CITELINE_API_KEY",
+            pharmapendium: "PHARMAPENDIUM_API_KEY",
+            cortellis: "CORTELLIS_API_KEY",
+            google_scholar: "SERPAPI_KEY",
+        };
+        for (const [src, envVar] of Object.entries(enterpriseKeys)) {
+            if (sources.includes(src) &&
+                !process.env[envVar] &&
+                !proxyActive) {
+                audit = addWarning(audit, `${src} requested but ${envVar} is not set and HEOR_PROXY_URL is not configured — ${src} results will be empty.`);
+            }
+        }
+        const allResults = [];
+        for (const source of sources) {
+            const start = Date.now();
+            try {
+                const results = await FETCHERS[source](params.query, maxPerSource);
+                const filtered = params.date_from
+                    ? results.filter((r) => !r.date || r.date >= params.date_from)
+                    : results;
+                audit = addSource(audit, {
+                    source,
+                    query_sent: params.query,
+                    results_returned: results.length,
+                    results_included: filtered.length,
+                    latency_ms: Date.now() - start,
+                    status: "ok",
+                });
+                allResults.push(...filtered);
+            }
+            catch (err) {
+                audit = addSource(audit, {
+                    source,
+                    query_sent: params.query,
+                    results_returned: 0,
+                    results_included: 0,
+                    latency_ms: Date.now() - start,
+                    status: "failed",
+                    error: err instanceof Error ? err.message : String(err),
+                });
+                audit = addWarning(audit, `Source ${source} failed: ${err instanceof Error ? err.message : String(err)}`);
+            }
+        }
+        if (params.project && allResults.length > 0) {
+            let savedCount = 0;
+            let errors = 0;
+            for (const result of allResults) {
+                try {
+                    await saveLiteratureResult(params.project, result, params.query);
+                    savedCount++;
+                }
+                catch {
+                    errors++;
+                }
+            }
+            audit = addAssumption(audit, `Auto-saved ${savedCount} results to project "${params.project}"${errors > 0 ? ` (${errors} errors)` : ""}`);
+        }
+        const profile = analyzeMetabolicProfile(allResults, params.query);
+        let content;
+        if (outputFormat === "json") {
+            content = { results: allResults, population_profile: profile };
+        }
+        else if (outputFormat === "docx") {
+            const base64 = await resultsToDocx(allResults, audit);
+            content = `[DOCX Report Generated - ${allResults.length} results]\n\nBase64-encoded DOCX (${Math.round(base64.length / 1024)}KB):\n${base64}`;
+        }
+        else {
+            const markdownContent = resultsToMarkdown(allResults, audit);
+            const profileMarkdown = profileToMarkdown(profile);
+            content = markdownContent + "\n" + profileMarkdown;
+        }
+        return { content, audit };
+    }
+    async buildCEModel(_params) {
+        throw new Error("DirectProvider.buildCEModel — implemented in costEffectivenessModel tool");
+    }
+    async prepDossier(_params) {
+        throw new Error("DirectProvider.prepDossier — implemented in htaDossierPrep tool");
+    }
+}
+//# sourceMappingURL=index.js.map

package/dist/providers/direct/index.js.map

@@ -0,0 +1 @@
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package/dist/providers/direct/inesss.d.ts

@@ -0,0 +1,3 @@
+import type { LiteratureResult } from "../types.js";
+export declare function fetchInesss(query: string, maxResults: number): Promise<LiteratureResult[]>;
+//# sourceMappingURL=inesss.d.ts.map

package/dist/providers/direct/inesss.d.ts.map

@@ -0,0 +1 @@
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