@sjcrh/proteinpaint-client 2.222.0 → 2.224.0

package/dist/block.tk.hicstraw-MVLZALFC.js

@@ -1,814 +0,0 @@
-import {
-  hicparsefragdata,
-  hicparsestat
-} from "./chunk-FJ2JV2VK.js";
-import {
-  ColorScale
-} from "./chunk-4ASBDE27.js";
-import "./chunk-HJ6L54YS.js";
-import "./chunk-OF6FDDKV.js";
-import "./chunk-CNFTQSNE.js";
-import "./chunk-RIHO7ZD5.js";
-import "./chunk-TVJOSRCH.js";
-import "./chunk-3CIL7KH7.js";
-import "./chunk-T4XPCSLP.js";
-import {
-  dofetch2
-} from "./chunk-4TJO2DGU.js";
-import "./chunk-W5J3LTYS.js";
-import "./chunk-MHWYRNGA.js";
-import "./chunk-JHLF2ZC2.js";
-import {
-  bplen
-} from "./chunk-WJLRU5OF.js";
-import "./chunk-HBNB5TRH.js";
-import "./chunk-PF4DSFDR.js";
-import "./chunk-4OLM3KSB.js";
-import "./chunk-PWYMHUXY.js";
-import "./chunk-TLT4YIG3.js";
-import "./chunk-5R63Q5KH.js";
-import "./chunk-I6Y4O3RR.js";
-import {
-  rgb
-} from "./chunk-Q5RDQNIT.js";
-import "./chunk-HS5PO5ZQ.js";
-
-// src/block.tk.hicstraw.ts
-var defaultnmeth = "NONE";
-var minimumbinnum_bp = 200;
-var minimumbinnum_frag = 200;
-var labyspace = 5;
-var insidedomaincolor = "102,102,102";
-var docurl_text = "https://github.com/stjude/proteinpaint/wiki/Interaction-Tracks:-Hi%E2%80%90C-and-Arc#text-data-copy--paste";
-function loadTk(tk, block) {
-  block.tkcloakon(tk);
-  block.block_setheight();
-  Promise.resolve().then(() => {
-    if (!tk.uninitialized) return;
-    delete tk.uninitialized;
-    makeTk(tk, block);
-    if (tk.textdata || tk.bedfile || tk.bedurl) return;
-    return dofetch2("hicstat?" + (tk.file ? "file=" + tk.file : "url=" + tk.url)).then((data) => {
-      if (data.error) throw data.error;
-      const err = hicparsestat(tk.hic, data.out);
-      if (err) throw err;
-    });
-  }).then(() => {
-    return setResolution(tk, block);
-  }).then(() => {
-    return mayLoadDomainoverlay(tk);
-  }).then(() => {
-    if (tk.textdata) return textdata_load(tk, block);
-    if (tk.bedfile || tk.bedurl) return bedfile_load(tk, block);
-    updateNormalizationArray(tk.hic);
-    return loadStrawdata(tk, block);
-  }).then(() => {
-    if (tk.data.length == 0) {
-      tk.height_main = 100;
-      tk.img.attr("width", 0);
-      throw tk.name + ": no data in view range";
-    }
-    drawCanvas(tk, block);
-  }).catch((err) => {
-    if (err.stack) {
-      console.error(err.stack);
-    }
-    return typeof err == "string" ? err : err.message;
-  }).then((errmsg) => {
-    block.tkcloakoff(tk, { error: errmsg });
-    block.block_setheight();
-  });
-}
-function setResolution(tk, block) {
-  const regions = [];
-  let x = 0;
-  for (let i = block.startidx; i <= block.stopidx; i++) {
-    const r = block.rglst[i];
-    regions.push({
-      chr: r.chr,
-      start: r.start,
-      stop: r.stop,
-      width: r.width,
-      x: x + (i == 0 ? 0 : 1) * block.regionspace
-    });
-    x += block.regionspace + r.width;
-  }
-  for (const r of block.subpanels) {
-    regions.push({
-      chr: r.chr,
-      start: r.start,
-      stop: r.stop,
-      width: r.width,
-      x: x + r.leftpad
-    });
-    x += r.leftpad + r.width;
-  }
-  tk.regions = regions;
-  if (tk.textdata || tk.bedfile || tk.bedurl) {
-    return;
-  }
-  const maxbpwidth = Math.max(...regions.map((i) => i.stop - i.start));
-  let resolution_bp = null;
-  for (const res of tk.hic.bpresolution) {
-    if (maxbpwidth / res > minimumbinnum_bp) {
-      resolution_bp = res;
-      break;
-    }
-  }
-  return Promise.resolve().then(() => {
-    if (resolution_bp) {
-      return;
-    }
-    if (!tk.hic.enzymefile || !tk.hic.fragresolution?.length) {
-      resolution_bp = tk.hic.bpresolution[tk.hic.bpresolution.length - 1];
-      return;
-    }
-    const tasks = [];
-    for (const r of regions) {
-      const arg = {
-        getdata: 1,
-        getBED: 1,
-        file: tk.hic.enzymefile,
-        rglst: [{ chr: r.chr, start: r.start, stop: r.stop }],
-        genome: block.genome.name
-      };
-      tasks.push(
-        dofetch2("tkbedj", { method: "POST", body: JSON.stringify(arg) }).then((data) => {
-          if (data.error) throw data.error;
-          if (!data.items) throw ".items[] missing at mapping coord to fragment index";
-          const [err, map, start, stop] = hicparsefragdata(data.items);
-          if (err) throw err;
-          r.frag = {
-            id2coord: map,
-            startidx: start,
-            stopidx: stop
-          };
-          return;
-        })
-      );
-    }
-    return Promise.all(tasks);
-  }).then(() => {
-    let resolution_frag;
-    if (!resolution_bp) {
-      const maxfragspan = Math.max(...regions.map((i) => i.frag.stopidx - i.frag.startidx));
-      for (const v of tk.hic.fragresolution) {
-        if (maxfragspan / v > minimumbinnum_frag) {
-          resolution_frag = v;
-          break;
-        }
-      }
-      if (!resolution_frag) {
-        resolution_frag = tk.hic.fragresolution[tk.hic.fragresolution.length - 1];
-      }
-    }
-    tk.resolution_bp = resolution_bp;
-    tk.resolution_frag = resolution_frag;
-    if (resolution_bp) {
-      tk.label_resolution.text("Resolution: " + bplen(resolution_bp));
-    } else {
-      tk.label_resolution.text("Resolution: " + resolution_frag + " fragment" + (resolution_frag > 1 ? "s" : ""));
-    }
-    return;
-  });
-}
-function mayLoadDomainoverlay(tk) {
-  if (!tk.domainoverlay || !tk.domainoverlay.inuse) return;
-  return Promise.resolve().then(() => {
-    const tasks = [];
-    for (const r of tk.regions) {
-      const arg = { getdata: 1, getBED: 1, rglst: [{ chr: r.chr, start: r.start, stop: r.stop }] };
-      if (tk.domainoverlay.file) {
-        arg.file = tk.domainoverlay.file;
-      } else {
-        arg.url = tk.domainoverlay.url;
-      }
-      tasks.push(
-        dofetch2("tkbedj", { method: "POST", body: JSON.stringify(arg) }).then((data) => {
-          if (data.error) throw data.error;
-          if (!data.items || data.items.length == 0) return;
-          r.domainlst = data.items;
-        })
-      );
-    }
-    return Promise.all(tasks);
-  });
-}
-function textdata_load(tk, block) {
-  tk.data = [];
-  for (const i of tk.textdata.lst) {
-    const point = coordpair2plotpoint(i.chr1, i.start1, i.stop1, i.chr2, i.start2, i.stop2, block);
-    if (point) {
-      point.push(i.value);
-      tk.data.push(point);
-    }
-  }
-}
-function coordpair2plotpoint(chr1, start1, stop1, chr2, start2, stop2, block) {
-  let left1 = map_point(chr1, start1, block);
-  let left2 = map_point(chr1, stop1, block);
-  if (left1 == -1 && left2 == -1) return;
-  if (left1 == -1) left1 = left2;
-  else if (left2 == -1) left2 = left1;
-  let right1 = map_point(chr2, start2, block);
-  let right2 = map_point(chr2, stop2, block);
-  if (right1 == -1 && right2 == -1) return;
-  if (right1 == -1) right1 = right2;
-  else if (right2 == -1) right2 = right1;
-  if (left1 < right1) return [left1, left2, right1, right2];
-  return [right1, right2, left1, left2];
-}
-function map_point(chr, pos, block) {
-  const lst = block.seekcoord(chr, pos);
-  for (const r of lst) {
-    if (r.ridx != void 0) {
-      if (r.x > 0 && r.x < block.width) return r.x;
-    } else if (r.subpanelidx != void 0) {
-      return r.x;
-    }
-  }
-  return -1;
-}
-function bedfile_load(tk, block) {
-  const arg = {
-    getdata: 1,
-    getBED: 1,
-    rglst: tk.regions.map((i) => {
-      return { chr: i.chr, start: i.start, stop: i.stop };
-    }),
-    genome: block.genome.name
-  };
-  if (tk.bedfile) {
-    arg.file = tk.bedfile;
-  } else {
-    arg.url = tk.bedurl;
-    if (tk.bedindexURL) arg.indexURL = tk.bedindexURL;
-  }
-  return dofetch2("tkbedj", { method: "POST", body: JSON.stringify(arg) }).then((data) => {
-    if (data.error) throw data.error;
-    tk.data = [];
-    if (!data.items) {
-      return;
-    }
-    const usedlines = /* @__PURE__ */ new Set();
-    for (const i of data.items) {
-      const skipline = i.chr + " " + i.start + " " + i.stop + " " + i.rest[0] + " " + i.rest[1] + " " + i.rest[2];
-      if (usedlines.has(skipline)) continue;
-      const thisline = i.rest[0] + " " + i.rest[1] + " " + i.rest[2] + " " + i.chr + " " + i.start + " " + i.stop;
-      usedlines.add(thisline);
-      const chr2 = i.rest[0];
-      const start2 = Number.parseInt(i.rest[1]);
-      const stop2 = Number.parseInt(i.rest[2]);
-      if (Number.isNaN(start2)) throw "invalid start2 position: " + i.rest[1];
-      if (Number.isNaN(stop2)) throw "invalid stop2 position: " + i.rest[2];
-      const value = Number.parseFloat(i.rest[3]);
-      if (Number.isNaN(value)) throw "invalid value: " + i.rest[3];
-      const point = coordpair2plotpoint(i.chr, i.start, i.stop, chr2, start2, stop2, block);
-      if (point) {
-        point.push(value);
-        tk.data.push(point);
-      }
-    }
-  });
-}
-function updateNormalizationArray(hic) {
-  if (hic.normalization?.length > 0 && !hic.normalization.includes(defaultnmeth)) {
-    hic.normalization.unshift(defaultnmeth);
-  }
-}
-function loadStrawdata(tk, block) {
-  const resolution_bp = tk.resolution_bp;
-  const resolution_frag = tk.resolution_frag;
-  for (const r of tk.regions) {
-    r._str = (tk.hic.nochr ? r.chr.replace("chr", "") : r.chr) + ":" + (resolution_bp ? r.start + ":" + r.stop : r.frag.startidx + ":" + r.frag.stopidx);
-  }
-  const tasks = [];
-  for (const [i, r] of tk.regions.entries()) {
-    const par = {
-      jwt: block.jwt,
-      file: tk.file,
-      url: tk.url,
-      pos1: r._str,
-      pos2: r._str,
-      nmeth: tk.normalizationmethod,
-      mincutoff: tk.mincutoff
-    };
-    if (resolution_bp) {
-      par.resolution = resolution_bp;
-    } else {
-      par.resolution = resolution_frag;
-      par.isfrag = true;
-    }
-    tasks.push(
-      dofetch2("hicdata", {
-        method: "POST",
-        body: JSON.stringify(par)
-      }).then((data) => {
-        if (data.error) throw data.error;
-        if (!data.items || data.items.length == 0) {
-          return null;
-        }
-        return {
-          items: data.items,
-          regionidx: i
-        };
-      })
-    );
-  }
-  for (let i = 0; i < tk.regions.length - 1; i++) {
-    for (let j = i + 1; j < tk.regions.length; j++) {
-      const par = {
-        jwt: block.jwt,
-        file: tk.file,
-        url: tk.url,
-        pos1: tk.regions[i]._str,
-        pos2: tk.regions[j]._str,
-        nmeth: tk.normalizationmethod,
-        mincutoff: tk.mincutoff
-      };
-      if (resolution_bp) {
-        par.resolution = resolution_bp;
-      } else {
-        par.resolution = resolution_frag;
-        par.isfrag = true;
-      }
-      tasks.push(
-        dofetch2("hicdata", {
-          method: "POST",
-          body: JSON.stringify(par)
-        }).then((data) => {
-          if (data.error) throw { message: data.error };
-          if (!data.items || data.items.length == 0) {
-            return null;
-          }
-          return {
-            items: data.items,
-            leftregionidx: i,
-            rightregionidx: j
-          };
-        })
-      );
-    }
-  }
-  return Promise.all(tasks).then((data) => {
-    return parseStrawData(data, resolution_bp, resolution_frag, tk, block);
-  });
-}
-function parseStrawData(datalst, resolution_bp, resolution_frag, tk, block) {
-  tk.data = [];
-  for (const data of datalst) {
-    if (!data) {
-      continue;
-    }
-    let r_left, r_right, fs_left, fs_right;
-    let firstisleft = false;
-    if (data.regionidx != void 0) {
-      r_left = r_right = tk.regions[data.regionidx];
-      fs_left = fs_right = r_left.width / (r_left.stop - r_left.start);
-      firstisleft = true;
-    } else {
-      r_left = tk.regions[data.leftregionidx];
-      fs_left = r_left.width / (r_left.stop - r_left.start);
-      r_right = tk.regions[data.rightregionidx];
-      fs_right = r_right.width / (r_right.stop - r_right.start);
-      firstisleft = tk.hic.chrorder.indexOf(r_left.chr) < tk.hic.chrorder.indexOf(r_right.chr);
-    }
-    for (const [n1, n2, v] of data.items) {
-      let coord1, coord2, span1, span2;
-      if (resolution_frag) {
-        const idx_left = firstisleft ? n1 : n2;
-        const idx_right = firstisleft ? n2 : n1;
-        let a = r_left.frag.id2coord.get(idx_left);
-        if (!a) {
-          a = r_right.frag.id2coord.get(idx_left);
-          if (!a) return "unknown frag id in region " + data.leftregionidx + ": " + idx_left;
-        }
-        coord1 = a[0];
-        span1 = a[1] - a[0];
-        if (r_left.frag.id2coord.has(idx_left + resolution_frag)) {
-          const x = r_left.frag.id2coord.get(idx_left + resolution_frag);
-          span1 = x[1] - coord1;
-        }
-        let b = r_right.frag.id2coord.get(idx_right);
-        if (!b) {
-          b = r_left.frag.id2coord.get(idx_right);
-          if (!b) return "unknown frag id in region " + data.rightregionidx + ": " + idx_right;
-        }
-        coord2 = b[0];
-        span2 = b[1] - b[0];
-        if (r_right.frag.id2coord.has(idx_right + resolution_frag)) {
-          const x = r_right.frag.id2coord.get(idx_right + resolution_frag);
-          span2 = x[1] - coord2;
-        }
-      } else {
-        coord1 = firstisleft ? n1 : n2;
-        coord2 = firstisleft ? n2 : n1;
-        span1 = span2 = resolution_bp;
-      }
-      let insidedomain = false;
-      if (tk.domainoverlay && tk.domainoverlay.inuse) {
-        if (data.regionidx != void 0) {
-          if (r_left.domainlst) {
-            if (r_left.domainlst.find((i) => i.start <= coord1 && i.stop >= coord2)) {
-              insidedomain = true;
-            }
-          }
-        } else {
-        }
-      }
-      if (data.leftregionidx != void 0 && r_left.chr == r_right.chr) {
-        if (coord1 > r_left.start - span1 && coord1 < r_left.stop && coord2 > r_right.start - span2 && coord2 < r_right.stop) {
-          const left1 = r_left.x + fs_left * (coord1 - r_left.start);
-          const left2 = left1 + fs_left * span1;
-          const right1 = r_right.x + fs_right * (coord2 - r_right.start);
-          const right2 = right1 + fs_right * span2;
-          tk.data.push([left1, left2, right1, right2, v, insidedomain]);
-        }
-        if (coord2 > r_left.start - span2 && coord2 < r_left.stop && coord1 > r_right.start && coord1 < r_right.stop) {
-          const left1 = r_left.x + fs_left * (coord2 - r_left.start);
-          const left2 = left1 + fs_left * span2;
-          const right1 = r_right.x + fs_right * (coord1 - r_right.start);
-          const right2 = right1 + fs_right * span1;
-          tk.data.push([left1, left2, right1, right2, v, insidedomain]);
-        }
-      } else {
-        const left1 = r_left.x + fs_left * (coord1 - r_left.start);
-        const left2 = left1 + fs_left * span1;
-        const right1 = r_right.x + fs_right * (coord2 - r_right.start);
-        const right2 = right1 + fs_right * span2;
-        tk.data.push([left1, left2, right1, right2, v, insidedomain]);
-      }
-    }
-  }
-  drawCanvas(tk, block);
-  return;
-}
-function drawCanvas(tk, block) {
-  if (tk.data.length == 0) return;
-  let rgbstring;
-  {
-    const t = rgb(tk.color);
-    rgbstring = t.r + "," + t.g + "," + t.b;
-  }
-  const canvas = tk.hiddencanvas.node();
-  const canvaswidth = block.width + block.subpanels.reduce((i, j) => i + j.leftpad + j.width, 0);
-  let canvasheight = 0;
-  if (tk.mode_hm) {
-    canvasheight = Math.min(
-      canvaswidth,
-      tk.data.reduce((i, j) => Math.max(i, (j[3] - j[0]) / 2), 0)
-    );
-  } else if (tk.mode_arc) {
-    for (const i of tk.data) {
-      const arcxspan = (i[2] + i[3]) / 2 - (i[0] + i[1]) / 2;
-      const h = arcxspan / 2 / Math.tan((Math.PI - tk.arcangle / 2) / 2);
-      canvasheight = Math.max(canvasheight, h);
-    }
-  }
-  canvas.width = canvaswidth;
-  canvas.height = canvasheight;
-  const ctx = canvas.getContext("2d");
-  if (window.devicePixelRatio > 1) {
-    canvas.width = canvaswidth * window.devicePixelRatio;
-    canvas.height = canvasheight * window.devicePixelRatio;
-    ctx.scale(window.devicePixelRatio, window.devicePixelRatio);
-  }
-  let maxv;
-  {
-    const values = tk.data.map((i) => i[4]);
-    values.sort((i, j) => i - j);
-    maxv = values[Math.floor(values.length * tk.percentile_max / 100)];
-  }
-  resize_label(tk, block);
-  for (const [left1, left2, right1, right2, value, insidedomain] of tk.data) {
-    if (value < tk.mincutoff) {
-      continue;
-    }
-    let color;
-    if (insidedomain) {
-      color = "rgba(" + insidedomaincolor + "," + (value / maxv).toFixed(2) + ")";
-    } else {
-      color = "rgba(" + rgbstring + "," + (value / maxv).toFixed(2) + ")";
-    }
-    if (tk.mode_hm) {
-      ctx.fillStyle = color;
-      ctx.beginPath();
-      let x1, y1, x2, y2, x3, y3, x4, y4;
-      if (tk.pyramidup) {
-        x1 = (left1 + right2) / 2;
-        y1 = canvasheight - (right2 - left1) / 2;
-        x2 = (left1 + right1) / 2;
-        y2 = canvasheight - (right1 - left1) / 2;
-        x3 = (left2 + right1) / 2;
-        y3 = canvasheight - (right1 - left2) / 2;
-        x4 = (left2 + right2) / 2;
-        y4 = canvasheight - (right2 - left2) / 2;
-      } else {
-        x1 = (left2 + right1) / 2;
-        y1 = (right1 - left2) / 2;
-        x2 = (left1 + right1) / 2;
-        y2 = (right1 - left1) / 2;
-        x3 = (left1 + right2) / 2;
-        y3 = (right2 - left1) / 2;
-        x4 = (left2 + right2) / 2;
-        y4 = (right2 - left2) / 2;
-      }
-      ctx.moveTo(x1, y1);
-      ctx.lineTo(x2, y2);
-      ctx.lineTo(x3, y3);
-      ctx.lineTo(x4, y4);
-      ctx.closePath();
-      ctx.fill();
-    } else if (tk.mode_arc) {
-      const a = (left1 + left2) / 2;
-      const b = (right1 + right2) / 2;
-      const arcxspan = Math.abs(a - b);
-      const centerx = Math.min(a, b) + arcxspan / 2;
-      const radius = arcxspan / 2 / Math.sin(tk.arcangle / 2);
-      let centery, startangle, endangle;
-      if (tk.pyramidup) {
-        centery = canvasheight + radius * Math.cos(tk.arcangle / 2);
-        startangle = Math.PI + (Math.PI - tk.arcangle) / 2;
-        endangle = startangle + tk.arcangle;
-      } else {
-        centery = -radius * Math.cos(tk.arcangle / 2);
-        startangle = (Math.PI - tk.arcangle) / 2;
-        endangle = startangle + tk.arcangle;
-      }
-      ctx.strokeStyle = color;
-      ctx.beginPath();
-      ctx.arc(centerx, centery, radius, startangle, endangle);
-      ctx.stroke();
-    }
-  }
-  tk.img.attr("width", canvaswidth).attr("height", canvasheight).attr("xlink:href", canvas.toDataURL());
-  tk.colorScale.domain = [0, maxv];
-  tk.colorScale.markedValue = tk.mincutoff;
-  tk.colorScale.updateScale();
-  tk.height_main = tk.toppad + Math.max(tk.left_labelheight, canvasheight) + tk.bottompad;
-}
-function resize_label(tk, block) {
-  tk.leftLabelMaxwidth = tk.colorScale.barwidth;
-  tk.tklabel.each(function() {
-    tk.leftLabelMaxwidth = Math.max(tk.leftLabelMaxwidth, this.getBBox().width);
-  });
-  if (tk.label_resolution) {
-    tk.label_resolution.each(function() {
-      tk.leftLabelMaxwidth = Math.max(tk.leftLabelMaxwidth, this.getBBox().width);
-    });
-  }
-  block.setllabel();
-}
-function makeTk(tk, block) {
-  if (tk.textdata) {
-    if (!tk.textdata.raw) throw ".raw missing from textdata";
-    const err = textdata_parseraw(tk, block);
-    if (err) throw "Error with text data: " + err;
-  }
-  if (tk.mode_hm == void 0) tk.mode_hm = true;
-  if (tk.mode_arc == void 0) tk.mode_arc = false;
-  if (tk.mode_hm && tk.mode_arc) {
-    tk.mode_arc = false;
-  } else if (!tk.mode_hm && !tk.mode_arc) {
-    tk.mode_hm = true;
-  }
-  if (!tk.color) tk.color = "#ff0000";
-  tk.arcangle = Math.PI / 2;
-  if (tk.pyramidup == void 0) tk.pyramidup = true;
-  tk.hic.genome = block.genome;
-  if (tk.hic.enzyme) {
-    if (block.genome.hicenzymefragment) {
-      const e = block.genome.hicenzymefragment.find((i) => i.enzyme.toUpperCase() == tk.hic.enzyme.toUpperCase());
-      if (e) {
-        tk.hic.enzymefile = e.file;
-      } else {
-        block.error("unknown Hi-C enzyme: " + tk.hic.enzyme);
-        delete tk.hic.enzyme;
-      }
-    } else {
-      block.error("Hi-C enzyme fragment not available for this genome");
-      delete tk.hic.enzyme;
-    }
-  }
-  if (!tk.percentile_max) {
-    tk.percentile_max = 90;
-  }
-  if (tk.mincutoff == void 0) {
-    tk.mincutoff = 0;
-  }
-  if (!tk.normalizationmethod) {
-    tk.normalizationmethod = defaultnmeth;
-  }
-  let laby = labyspace + block.labelfontsize;
-  if (tk.file || tk.url) {
-    tk.label_resolution = block.maketklefthandle(tk, laby).attr("class", null);
-    laby += labyspace + block.labelfontsize;
-  }
-  {
-    const barheight = 14;
-    const barwidth = 100;
-    const space = 1;
-    const holder = tk.gleft.append("g").attr("transform", `scale(1), translate(${block.tkleftlabel_xshift - barwidth}, ${laby})`);
-    tk.colorScale = new ColorScale({
-      barheight,
-      barwidth,
-      //data will update after loading data
-      domain: [0, 1],
-      fontSize: 12,
-      height: 45,
-      width: 120,
-      holder,
-      colors: ["white", tk.color],
-      position: `6,${barheight + space}`,
-      ticks: 2,
-      tickSize: 2,
-      markedValue: tk.mincutoff
-    });
-    laby += barheight + 10 + block.labelfontsize;
-  }
-  laby += 10;
-  tk.left_labelheight = laby;
-  tk.img = tk.glider.append("image");
-  tk.hiddencanvas = block.holder.append("canvas").style("display", "none");
-  tk.config_handle = block.maketkconfighandle(tk).on("click", () => {
-    configPanel(tk, block);
-  });
-}
-function configPanel(tk, block) {
-  tk.tkconfigtip.clear().showunder(tk.config_handle.node());
-  if (tk.textdata) {
-    tk.tkconfigtip.d.append("div").attr("class", "sja_menuoption").attr("data-testid", "sjpp-edit-interaction-data").style("margin-bottom", "10px").text("Edit interaction data").on("click", () => {
-      textdata_editUI(tk, block);
-    });
-  }
-  {
-    const row = tk.tkconfigtip.d.append("div").style("margin-bottom", "10px");
-    row.append("span").text("Change color");
-    row.append("input").style("margin-left", "5px").attr("type", "color").property("value", tk.color).on("change", (event) => {
-      tk.color = event.target.value;
-      tk.colorScale.colors[tk.colorScale.colors.length - 1] = tk.color;
-      tk.colorScale.updateScale();
-      drawCanvas(tk, block);
-    });
-  }
-  {
-    const row = tk.tkconfigtip.d.append("div").style("margin-bottom", "10px");
-    row.append("input").attr("type", "number").style("width", "40px").property("value", tk.percentile_max).on("keyup", (event) => {
-      if (event.code != "Enter" && event.code != "NumpadEnter") return;
-      const v = Number.parseFloat(event.target.value);
-      if (Number.isNaN(v) || v <= 0 || v >= 100) {
-        alert("Please enter a value between 0 and 100");
-        return;
-      }
-      tk.percentile_max = v;
-      drawCanvas(tk, block);
-    });
-    row.append("span").html("&nbsp;percentile for color scale max");
-  }
-  {
-    const row = tk.tkconfigtip.d.append("div").style("margin-bottom", "10px");
-    row.append("input").attr("type", "number").style("width", "50px").property("value", tk.mincutoff).on("keyup", (event) => {
-      if (event.code != "Enter" && event.code != "NumpadEnter") return;
-      const v = Number.parseFloat(event.target.value);
-      if (Number.isNaN(v)) {
-        alert("Please enter a valid number");
-        return;
-      }
-      tk.mincutoff = v;
-      loadTk(tk, block);
-    });
-    row.append("span").html("&nbsp;for minimum cutoff value");
-    row.append("div").style("font-size", ".8em").style("opacity", 0.5).html("Interactions with scores &le; cutoff will not be shown.");
-  }
-  if (tk.file || tk.url) {
-    const normalization = tk.hic.normalization;
-    const row = tk.tkconfigtip.d.append("div").style("margin-bottom", "10px");
-    row.append("span").html("Normalization&nbsp;");
-    if (tk.hic.normalization.length > 0) {
-      const s = row.append("select").on("change", () => {
-        const ss = s.node();
-        tk.normalizationmethod = ss.options[ss.selectedIndex].innerHTML;
-        loadTk(tk, block);
-      });
-      for (const method of normalization) s.append("option").text(method);
-      for (const o of s.node().options) {
-        if (o.innerHTML == tk.normalizationmethod) {
-          o.selected = true;
-          break;
-        }
-      }
-    } else {
-      row.append("span").text(defaultnmeth);
-    }
-  }
-  if (tk.domainoverlay) {
-    const row = tk.tkconfigtip.d.append("div").style("margin-bottom", "10px");
-    row.append("span").html("Overlay with " + tk.domainoverlay.name + " domains&nbsp;");
-    row.append("button").text(tk.domainoverlay.inuse ? "No" : "Yes").on("click", () => {
-      tk.tkconfigtip.hide();
-      tk.domainoverlay.inuse = !tk.domainoverlay.inuse;
-      loadTk(tk, block);
-    });
-  }
-  {
-    const row = tk.tkconfigtip.d.append("div").style("margin-bottom", "10px");
-    const id = Math.random().toString();
-    row.append("input").attr("name", id).attr("id", id + "1").attr("type", "radio").property("checked", tk.mode_hm).on("change", (event) => {
-      if (event.target.checked) {
-        tk.mode_hm = true;
-        tk.mode_arc = false;
-      } else {
-        tk.mode_hm = false;
-        tk.mode_arc = true;
-      }
-      drawCanvas(tk, block);
-      block.block_setheight();
-    });
-    row.append("label").attr("for", id + "1").attr("class", "sja_clbtext").html("&nbsp;Heatmap");
-    row.append("input").style("margin-left", "10px").attr("name", id).attr("id", id + "2").attr("type", "radio").property("checked", tk.mode_arc).on("change", (event) => {
-      if (event.target.checked) {
-        tk.mode_hm = false;
-        tk.mode_arc = true;
-      } else {
-        tk.mode_hm = true;
-        tk.mode_arc = false;
-      }
-      drawCanvas(tk, block);
-      block.block_setheight();
-    });
-    row.append("label").attr("for", id + "2").attr("class", "sja_clbtext").html("&nbsp;Arc");
-    row.append("span").style("margin-left", "10px").style("opacity", 0.5).text("for showing interactions.");
-  }
-  {
-    tk.tkconfigtip.d.append("div").style("margin", "20px 0px").append("button").text("Point " + (tk.pyramidup ? "down" : "up")).on("click", () => {
-      tk.pyramidup = !tk.pyramidup;
-      drawCanvas(tk, block);
-      tk.tkconfigtip.hide();
-    });
-  }
-  if (tk.hic.version) {
-    tk.tkconfigtip.d.append("div").style("opacity", 0.5).text("HiC file version: " + tk.hic.version);
-  }
-}
-function textdata_editUI(tk, block) {
-  tk.tkconfigtip.d.transition().style("left", Number.parseInt(tk.tkconfigtip.d.style("left")) - 500 + "px");
-  tk.tkconfigtip.clear();
-  const d = tk.tkconfigtip.d.append("div");
-  const ta = d.append("textarea").attr("cols", 50).attr("rows", 10);
-  ta.property("value", tk.textdata.raw);
-  const row2 = d.append("div").style("margin-top", "10px");
-  row2.append("button").text("Update").on("click", () => {
-    const text = ta.property("value");
-    if (!text) {
-      window.alert("Enter text interaction data");
-      return;
-    }
-    tk.textdata.raw = text;
-    const err = textdata_parseraw(tk, block);
-    if (err) {
-      window.alert(err);
-      return;
-    }
-    loadTk(tk, block);
-    tk.tkconfigtip.hide();
-  });
-  row2.append("span").style("margin-left", "5px").html("<a href=" + docurl_text + " target=_blank>Text data format</a>");
-  row2.append("button").style("margin-left", "30px").text("Cancel").on("click", () => tk.tkconfigtip.hide());
-}
-function textdata_parseraw(tk, block) {
-  tk.textdata.lst = [];
-  const lines = tk.textdata.raw.trim().split(/\r?\n/);
-  for (let i = 0; i < lines.length; i++) {
-    const line = lines[i].trim();
-    if (!line) continue;
-    const l = line.split(/[\t\s]+/);
-    const chr1 = l[0];
-    if (!block.genome.chrlookup[chr1.toUpperCase()]) return "wrong chrA name at line " + (i + 1);
-    const start1 = Number.parseInt(l[1]);
-    if (Number.isNaN(start1)) return "invalid startA at line " + (i + 1);
-    const stop1 = Number.parseInt(l[2]);
-    if (Number.isNaN(stop1)) return "invalid stopA name at line " + (i + 1);
-    const chr2 = l[3];
-    if (!block.genome.chrlookup[chr2.toUpperCase()]) return "wrong chrB name at line " + (i + 1);
-    const start2 = Number.parseInt(l[4]);
-    if (Number.isNaN(start2)) return "invalid startB at line " + (i + 1);
-    const stop2 = Number.parseInt(l[5]);
-    if (Number.isNaN(stop2)) return "invalid stopB at line " + (i + 1);
-    const value = Number.parseFloat(l[7]);
-    if (Number.isNaN(value)) return "invalid value (8th column) at line " + (i + 1);
-    tk.textdata.lst.push({
-      chr1,
-      start1,
-      stop1,
-      chr2,
-      start2,
-      stop2,
-      value
-    });
-  }
-  if (tk.textdata.lst.length == 0) return "No data points from text input";
-}
-export {
-  loadTk
-};
-//# sourceMappingURL=block.tk.hicstraw-MVLZALFC.js.map