@sjcrh/proteinpaint-client 2.203.0 → 2.203.1

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (884) hide show
  1. package/dist/2dmaf-6CEBP4SA.js +1366 -0
  2. package/dist/AIProjectAdmin-2CKKFC3A.js +951 -0
  3. package/dist/AggregateMatrix-5TBUMFE5.js +665 -0
  4. package/dist/AppHeader-5YBPWF44.js +829 -0
  5. package/dist/BoxPlot-UOJS5SJV.js +1210 -0
  6. package/dist/CorrelationVolcano-KX6JPZMT.js +613 -0
  7. package/dist/Cuminc-TLOOLZWR.js +1208 -0
  8. package/dist/DE-HUQLQ2Z3.js +87 -0
  9. package/dist/DEinput-WWUISAF2.js +404 -0
  10. package/dist/DifferentialAnalysis-6DTAGCEY.js +237 -0
  11. package/dist/Disco-P6ZLPYLF.js +3388 -0
  12. package/dist/Disco.UI-WGTMAFK2.js +242 -0
  13. package/dist/DmrPlot-3FRU5KUK.js +636 -0
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  15. package/dist/GSEA-DEEUAAMI.js +850 -0
  16. package/dist/GeneExpInput-6QWGEAFV.js +361 -0
  17. package/dist/Geomap-6HT2B7RH.js +83 -0
  18. package/dist/HicApp-PCNOUULF.js +2244 -0
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  36. package/dist/ProteomeInput-PRS3DEMZ.js +387 -0
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  153. package/dist/cohort-U7M6Q2UX.js +69 -0
  154. package/dist/condition-EGAV2PMJ.js +326 -0
  155. package/dist/controls-PTMYWUZV.js +33 -0
  156. package/dist/controls.config-DOA6PTP2.js +33 -0
  157. package/dist/correlation-Y3EL6GB7.js +94 -0
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  159. package/dist/dataDownload-EQGUAOK2.js +328 -0
  160. package/dist/databrowser.ui-ABGOJUWQ.js +424 -0
  161. package/dist/dictionary-YOLLEDE5.js +112 -0
  162. package/dist/dnaMethylation-JZT63UHO.js +32 -0
  163. package/dist/dnaMethylation.integration.spec-EATCABJW.js +197 -0
  164. package/dist/dofetch-YNBIUFV5.js +48 -0
  165. package/dist/e2pca-RD6COCRL.js +343 -0
  166. package/dist/ep-BAI7WUET.js +1248 -0
  167. package/dist/expclust.gdc.spec-LKV2CQA5.js +301 -0
  168. package/dist/facet-X3SXQIAC.js +518 -0
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  170. package/dist/geneExpClustering-BJD5U3KG.js +243 -0
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  180. package/dist/genefusion.ui-4T5R7DT7.js +302 -0
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  183. package/dist/grin2-EXBG7TMS.js +1136 -0
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  240. package/dist/proteinView-7GWHQYXC.js +1561 -0
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  818. /package/dist/{polar2-JKV74QV5.js.map → polar2-AB6SVYRS.js.map} +0 -0
  819. /package/dist/{profileForms-VDYCFH4M.js.map → profileForms-AIEHZ4GC.js.map} +0 -0
  820. /package/dist/{plot.app-MOIVGIS6.js.map → profilePlot-PZDFGXKZ.js.map} +0 -0
  821. /package/dist/{proteinView-A3EM6OR5.js.map → proteinView-7GWHQYXC.js.map} +0 -0
  822. /package/dist/{pseudbulk.unit.spec-CUMTLAH7.js.map → pseudbulk.unit.spec-NFT4VNTI.js.map} +0 -0
  823. /package/dist/{profilePlot-PR3LVRYU.js.map → pseudobulk-WDGWTXW4.js.map} +0 -0
  824. /package/dist/{pseudobulk-5E5MSMU3.js.map → qualitative-PZYJENE7.js.map} +0 -0
  825. /package/dist/{radar2-A5OYMORS.js.map → radar2-QHRGH3YS.js.map} +0 -0
  826. /package/dist/{radarFacility2-4TPJB6M4.js.map → radarFacility2-2JD26FL6.js.map} +0 -0
  827. /package/dist/{qualitative-WPXUBISK.js.map → render-YA4Z56LT.js.map} +0 -0
  828. /package/dist/{report-NCJOTYIC.js.map → report-2NUKFJTF.js.map} +0 -0
  829. /package/dist/{render-XQBWWS33.js.map → sampleView-2XVPJTVR.js.map} +0 -0
  830. /package/dist/{samplelst-FV7BAUN5.js.map → samplelst-DMILFDT5.js.map} +0 -0
  831. /package/dist/{samplematrix-DFD3PNI4.js.map → samplematrix-LYA5XTUM.js.map} +0 -0
  832. /package/dist/{sc-GIMTDVLG.js.map → sc-CM2C34MN.js.map} +0 -0
  833. /package/dist/{scatter-4GJ5HKUY.js.map → scatter-C3CH3HTF.js.map} +0 -0
  834. /package/dist/{scatter-P3ISZB3R.js.map → scatter-GO6LV6NY.js.map} +0 -0
  835. /package/dist/{selectGenomeWithTklst-ZZ4CEHDU.js.map → selectGenomeWithTklst-5C7UBTGZ.js.map} +0 -0
  836. /package/dist/{sampleView-2PUSMG4W.js.map → singleCellCellType-EZYESBVZ.js.map} +0 -0
  837. /package/dist/{singleCellCellType.unit.spec-JNEIICK5.js.map → singleCellCellType.unit.spec-DB6FM4XR.js.map} +0 -0
  838. /package/dist/{singleCellCellType-CEERCVTR.js.map → singleCellGeneExpression-DZLEFPW4.js.map} +0 -0
  839. /package/dist/{singleCellGeneExpression.unit.spec-CGRZGY66.js.map → singleCellGeneExpression.unit.spec-ZTBK3V43.js.map} +0 -0
  840. /package/dist/{singleCellGeneExpression-G5B7DDES.js.map → singleCellPlot-VF4TZ4FT.js.map} +0 -0
  841. /package/dist/{singlecell-IPTSIKNA.js.map → singlecell-2MHROPBN.js.map} +0 -0
  842. /package/dist/{singlecell-VB4KLPJF.js.map → singlecell-GPAFNOUZ.js.map} +0 -0
  843. /package/dist/{singleCellPlot-US5KTHS4.js.map → snp-K4EAEVW4.js.map} +0 -0
  844. /package/dist/{snp.unit.spec-Q537NGVG.js.map → snp.unit.spec-BUVQLVOY.js.map} +0 -0
  845. /package/dist/{snplocus-BV6WJTVP.js.map → snplocus-GEVISN6Z.js.map} +0 -0
  846. /package/dist/{spliceevent.a53ss.diagram-3BUQVK4Q.js.map → spliceevent.a53ss.diagram-5UPWNAZF.js.map} +0 -0
  847. /package/dist/{spliceevent.exonskip.diagram-CQZ2DFQ5.js.map → spliceevent.exonskip.diagram-7TKAQURC.js.map} +0 -0
  848. /package/dist/{spliceevent.noeventdiagram-QAEPR6LD.js.map → spliceevent.noeventdiagram-CDXZLR3Z.js.map} +0 -0
  849. /package/dist/{snp-6V2SCCRN.js.map → ssGSEA-NMCJUQXT.js.map} +0 -0
  850. /package/dist/{ssGSEA.unit.spec-A337IMC7.js.map → ssGSEA.unit.spec-3FQALTPQ.js.map} +0 -0
  851. /package/dist/{stattable-J4ZQKJFM.js.map → stattable-2RXQPWKK.js.map} +0 -0
  852. /package/dist/{summarizeCnvGeneexp-76UJXLA4.js.map → summarizeCnvGeneexp-4BQS5AFM.js.map} +0 -0
  853. /package/dist/{summarizeGeneexpSurvival-ZUEHXA2R.js.map → summarizeGeneexpSurvival-HTBZQFB5.js.map} +0 -0
  854. /package/dist/{summarizeMutationCnv-EBCBVMG6.js.map → summarizeMutationCnv-XUWZGPCM.js.map} +0 -0
  855. /package/dist/{ssGSEA-XNI5S7AC.js.map → summarizeMutationDiagnosis-QUJX42TO.js.map} +0 -0
  856. /package/dist/{summarizeMutationSurvival-QRFMJLLO.js.map → summarizeMutationSurvival-3R47TTR6.js.map} +0 -0
  857. /package/dist/{summarizeMutationDiagnosis-VLFI2ZIZ.js.map → summary-6UUB63QR.js.map} +0 -0
  858. /package/dist/{summary.integration.spec-52WP6SNY.js.map → summary.integration.spec-JJDE6SRV.js.map} +0 -0
  859. /package/dist/{summaryInput-WUJNHCGH.js.map → summaryInput-JG4AW6FW.js.map} +0 -0
  860. /package/dist/{sunburst-IJ3ZG2BC.js.map → sunburst-YKB42RZX.js.map} +0 -0
  861. /package/dist/{survival-SQRYWGWZ.js.map → survival-3IFFTDQA.js.map} +0 -0
  862. /package/dist/{survival-F2B5JKOO.js.map → survival-HOFNJENX.js.map} +0 -0
  863. /package/dist/{svgraph-HVCMF6KI.js.map → svgraph-WFEY4ZIZ.js.map} +0 -0
  864. /package/dist/{svmr-PROHTMTP.js.map → svmr-44EIX7YD.js.map} +0 -0
  865. /package/dist/{table-3E64OJNV.js.map → table-6MKVJUNC.js.map} +0 -0
  866. /package/dist/{termCollection-WKT6ESMI.js.map → termCollection-6JBVQL6Y.js.map} +0 -0
  867. /package/dist/{summary-U3YKEMZC.js.map → termCollection-TTELZVC5.js.map} +0 -0
  868. /package/dist/{termCollection.unit.spec-XMOCMVER.js.map → termCollection.unit.spec-6Z7X646L.js.map} +0 -0
  869. /package/dist/{termCollection-MUH7P6B5.js.map → termCollectionFractionSelection-5DVIJBM5.js.map} +0 -0
  870. /package/dist/{termCollectionFractionSelection.unit.spec-MG7E3EIZ.js.map → termCollectionFractionSelection.unit.spec-3HIM5BIF.js.map} +0 -0
  871. /package/dist/{termCollectionFractionSelection-P5G6WIJJ.js.map → tk-HSYWJCGQ.js.map} +0 -0
  872. /package/dist/{tk-HWUPUGOS.js.map → tk-PNOVG2XS.js.map} +0 -0
  873. /package/dist/{tp.ui-RRB5MJRD.js.map → tp.ui-COBBSUPB.js.map} +0 -0
  874. /package/dist/{tk-SBM2GN3S.js.map → tvs.dt-35AKURFI.js.map} +0 -0
  875. /package/dist/{tvs.dtcnv.categorical-7RJPQKMX.js.map → tvs.dtcnv.categorical-3EHXYROL.js.map} +0 -0
  876. /package/dist/{tvs.dtcnv.continuous-FW4ZXIYY.js.map → tvs.dtcnv.continuous-AXQ2GU6S.js.map} +0 -0
  877. /package/dist/{tvs.dtfusion-3GDWW3ML.js.map → tvs.dtfusion-PLJIMPNX.js.map} +0 -0
  878. /package/dist/{tvs.dtitd-FER4H4UO.js.map → tvs.dtitd-JS6RFBV5.js.map} +0 -0
  879. /package/dist/{tvs.dtsnvindel-ISEOJ5UA.js.map → tvs.dtsnvindel-MDEM5MPT.js.map} +0 -0
  880. /package/dist/{tvs.dtsv-JDML7EWE.js.map → tvs.dtsv-OU756YLO.js.map} +0 -0
  881. /package/dist/{tvs.samplelst-MJTM6GSV.js.map → tvs.samplelst-5NDICES4.js.map} +0 -0
  882. /package/dist/{tvs.termCollection-GMOXBJWF.js.map → tvs.termCollection-5URPDPH6.js.map} +0 -0
  883. /package/dist/{tvs.dt-I2ECKHQ2.js.map → vocabulary-CHCVMPK5.js.map} +0 -0
  884. /package/dist/{wsi.direct-IVPACPNT.js.map → wsi.direct-JSKV4H4X.js.map} +0 -0
@@ -1,2244 +0,0 @@
1
- import {
2
- blocklazyload
3
- } from "./chunk-OGQMELRU.js";
4
- import {
5
- hicParseFile
6
- } from "./chunk-CBRZIMNF.js";
7
- import {
8
- AppBase,
9
- ColorScale,
10
- axisstyle,
11
- first_genetrack_tolist,
12
- font,
13
- newpane,
14
- showErrorsWithCounter,
15
- tkt
16
- } from "./chunk-GQQ4R6BI.js";
17
- import "./chunk-HJ6L54YS.js";
18
- import "./chunk-XFAL46LZ.js";
19
- import "./chunk-7AYGTMED.js";
20
- import {
21
- Menu
22
- } from "./chunk-ELJX3QIQ.js";
23
- import "./chunk-7BLXK3GI.js";
24
- import "./chunk-VSSZJHOR.js";
25
- import "./chunk-5RUVBYLK.js";
26
- import {
27
- dofetch3
28
- } from "./chunk-HENLCRVM.js";
29
- import "./chunk-4WF3XDQP.js";
30
- import "./chunk-7UFK4GVI.js";
31
- import {
32
- bplen
33
- } from "./chunk-4QBRVM4V.js";
34
- import {
35
- StoreBase,
36
- getAppInit,
37
- getCompInit,
38
- getStoreInit
39
- } from "./chunk-H6INPPUC.js";
40
- import "./chunk-PF4DSFDR.js";
41
- import "./chunk-IMYSFDE5.js";
42
- import "./chunk-W5J3LTYS.js";
43
- import {
44
- axisBottom,
45
- axisRight
46
- } from "./chunk-4ZL6IBXM.js";
47
- import {
48
- format,
49
- linear
50
- } from "./chunk-OZVWP4ZR.js";
51
- import "./chunk-FXQXCOII.js";
52
- import "./chunk-TLT4YIG3.js";
53
- import "./chunk-5R63Q5KH.js";
54
- import {
55
- pointer_default,
56
- select_default
57
- } from "./chunk-I6Y4O3RR.js";
58
- import "./chunk-Q5RDQNIT.js";
59
- import "./chunk-DQC5FFGV.js";
60
- import "./chunk-HFNDKYVF.js";
61
-
62
- // tracks/hic/HicStore.ts
63
- var HicStore = class _HicStore extends StoreBase {
64
- constructor(opts) {
65
- super(opts);
66
- this.views = ["genome", "chrpair", "detail", "horizontal"];
67
- this.type = _HicStore.type;
68
- this.defaultState = {
69
- defaultNmeth: "NONE",
70
- loading: true,
71
- minBinNum_bp: 200,
72
- minFragSpan: 200,
73
- initialBinNum: 20,
74
- settings: {
75
- widthHeightPx: 800
76
- }
77
- };
78
- }
79
- static {
80
- this.type = "store";
81
- }
82
- init() {
83
- this.state = Object.assign({}, this.defaultState, this.state);
84
- }
85
- };
86
- var hicStoreInit = getStoreInit(HicStore);
87
- HicStore.prototype.actions = {
88
- view_create(action) {
89
- if (!action.view) throw Error("view_create: missing view");
90
- if (!this.views.some((v) => v == action.view)) throw Error(`view_create: unknown view = ${action.view}`);
91
- this.state.currView = action.view;
92
- const opts = Object.assign(this.state, action.config);
93
- this.state = opts;
94
- },
95
- view_update(action) {
96
- if (action.view) {
97
- if (!this.views.some((v) => v == action.view)) throw Error(`view_update: unknown view = ${action.view}`);
98
- const opts = Object.assign(this.state[action.view], action.config);
99
- this.state[action.view] = opts;
100
- } else {
101
- const opts = Object.assign(this.state, action.config);
102
- this.state = opts;
103
- }
104
- },
105
- loading_active(action) {
106
- this.state.loading = action.active;
107
- }
108
- };
109
-
110
- // tracks/hic/dom/LoadingOverlay.ts
111
- var LoadingOverlay = class _LoadingOverlay {
112
- constructor(opts) {
113
- this.hasStatePreMain = true;
114
- this.type = _LoadingOverlay.type;
115
- this.app = opts.app;
116
- this.loadingDiv = opts.loadingDiv;
117
- }
118
- static {
119
- this.type = "loadingOverlay";
120
- }
121
- reactsTo(action) {
122
- if (action.type.startsWith("loading")) return true;
123
- else return false;
124
- }
125
- getState(appState) {
126
- return appState;
127
- }
128
- init() {
129
- this.loadingDiv.append("div").attr("class", "sjpp-spinner").style("display", "");
130
- }
131
- main(appState) {
132
- const loading = this.app.getState(appState).loading;
133
- this.loadingDiv.style("display", loading ? "" : "none");
134
- }
135
- };
136
- var loadingInit = getCompInit(LoadingOverlay);
137
-
138
- // tracks/hic/dom/ColorizeElement.ts
139
- var ColorizeElement = class {
140
- colorizeElement(xCoord, yCoord, v, obj, width, height, bpMinV, bpMaxV, currView) {
141
- if (v >= 0) {
142
- const p = v >= bpMaxV ? 0 : v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV - v) / bpMaxV);
143
- const positiveFill = `rgb(255, ${p}, ${p})`;
144
- if (currView === "genome") {
145
- obj.ctx.fillStyle = positiveFill;
146
- obj.ctx2.fillStyle = positiveFill;
147
- } else {
148
- obj.fillStyle = positiveFill;
149
- }
150
- } else {
151
- const p = v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV + v) / bpMaxV);
152
- const negativeFill = `rgb(${p}, ${p}, 255)`;
153
- if (currView === "genome") {
154
- obj.ctx.fillStyle = negativeFill;
155
- obj.ctx2.fillStyle = negativeFill;
156
- } else {
157
- obj.fillStyle = negativeFill;
158
- }
159
- }
160
- if (currView === "genome") {
161
- obj.ctx.fillRect(yCoord, xCoord, width, height);
162
- obj.ctx2.fillRect(xCoord, yCoord, width, height);
163
- } else {
164
- obj.fillRect(xCoord, yCoord, width, height);
165
- }
166
- }
167
- };
168
-
169
- // tracks/hic/data/Resolution.ts
170
- var Resolution = class {
171
- constructor(error) {
172
- this.error = error;
173
- }
174
- getResolution(state, hic) {
175
- if (state.currView == "genome") return hic["bpresolution"][0];
176
- if (state.currView == "chrpair") {
177
- const resolution = this.getChrPairResolution(hic, state.x, state.y, state.minBinNum_bp);
178
- return resolution;
179
- } else if (state.currView == "detail") {
180
- const maxBpWidth = Math.max(state.x.stop - state.x.start, state.y.stop - state.y.start);
181
- let resolution = this.findResFromArray(maxBpWidth, state.minBinNum_bp, hic.bpresolution);
182
- if (resolution == null && !hic.enzyme) {
183
- resolution = hic.bpresolution[hic.bpresolution.length - 1];
184
- }
185
- return resolution;
186
- } else {
187
- this.error(`Unknown view: ${state.currView}`);
188
- throw `Unknown view: ${state.currView}`;
189
- }
190
- }
191
- getChrPairResolution(hic, x, y, minBinNum_bp) {
192
- const chrxlen = hic.genome.chrlookup[x.chr.toUpperCase()].len;
193
- const chrylen = hic.genome.chrlookup[y.chr.toUpperCase()].len;
194
- const maxchrlen = Math.max(chrxlen, chrylen);
195
- const resolution = this.findResFromArray(maxchrlen, minBinNum_bp, hic.bpresolution);
196
- if (resolution == null) {
197
- this.error(`No suitable resolution for ${x.chr}-${y.chr} pair.`);
198
- return;
199
- }
200
- return resolution;
201
- }
202
- findResFromArray(max, defaultValue, resolutionArray, returnNum) {
203
- let resolution = null;
204
- for (const res of resolutionArray) {
205
- if (max / res > defaultValue) {
206
- resolution = res;
207
- break;
208
- }
209
- }
210
- if (returnNum && resolution == null) {
211
- resolution = resolutionArray[resolutionArray.length - 1];
212
- }
213
- return resolution;
214
- }
215
- getDefaultViewSpan(hic, x, y, initialBinNum, minBinNum_bp) {
216
- const chrpairResolution = this.getChrPairResolution(hic, x, y, minBinNum_bp);
217
- if (!chrpairResolution) return;
218
- return chrpairResolution * initialBinNum;
219
- }
220
- };
221
-
222
- // tracks/hic/data/Positions.ts
223
- var Positions = class {
224
- constructor(error, minBinNum_bp) {
225
- this.error = error;
226
- this.resolution = new Resolution(this.error);
227
- this.minBinNum_bp = minBinNum_bp;
228
- }
229
- /**
230
- *
231
- * @param x x coordinate of pointer
232
- * @param y y coordinate of pointer
233
- * @param binpx
234
- * @param chrx x chr from state
235
- * @param chry y chr from state
236
- * @param hic
237
- * @param initialBinNum Set in the state
238
- * @returns
239
- */
240
- setPosition(x, y, binpx, chrx, chry, hic, initialBinNum) {
241
- const resolution = this.resolution.getChrPairResolution(hic, chrx, chry, this.minBinNum_bp);
242
- const viewrangebpw = resolution * initialBinNum;
243
- let coordx = Math.max(1, Math.floor(x * resolution / binpx) - viewrangebpw / 2);
244
- let coordy = Math.max(1, Math.floor(y * resolution / binpx) - viewrangebpw / 2);
245
- {
246
- const lenx = hic.genome.chrlookup[chrx.chr.toUpperCase()].len;
247
- if (coordx + viewrangebpw >= lenx) {
248
- coordx = lenx - viewrangebpw;
249
- }
250
- const leny = hic.genome.chrlookup[chry.chr.toUpperCase()].len;
251
- if (coordy + viewrangebpw > leny) {
252
- coordy = leny - viewrangebpw;
253
- }
254
- }
255
- const xObj = {
256
- chr: chrx.chr,
257
- start: coordx,
258
- stop: coordx + viewrangebpw
259
- };
260
- const yObj = {
261
- chr: chry.chr,
262
- start: coordy,
263
- stop: coordy + viewrangebpw
264
- };
265
- return [xObj, yObj];
266
- }
267
- };
268
-
269
- // tracks/hic/data/GridElementsFormattedData.ts
270
- var GridElementsFormattedData = class {
271
- /**
272
- * Format the data for the grid elements.
273
- * @param items The data to format.
274
- * @param binpx The bin size in pixels.
275
- * @param resolution The resolution.
276
- * @param isFirstChrX Whether the first chromosome is X. Used for chrpair view.
277
- * @param isIntraChr Whether the data is intra-chromosomal. Used for chrpair view
278
- * @returns The formatted data.
279
- */
280
- formatData(view, items, binpx, resolution, isFirstChrX, isIntraChr) {
281
- const formattedData = [];
282
- for (const [xCoord, yCoord, value] of items) {
283
- const xPx = Math.floor(xCoord / resolution) * binpx;
284
- const yPx = Math.floor(yCoord / resolution) * binpx;
285
- if (view == "genome") {
286
- formattedData.push([xPx, yPx, value]);
287
- }
288
- if (view == "chrpair") {
289
- const x = isFirstChrX ? xPx : yPx;
290
- const y = isFirstChrX ? yPx : xPx;
291
- formattedData.push([x, y, value]);
292
- if (isIntraChr) {
293
- formattedData.push([y, x, value]);
294
- }
295
- }
296
- }
297
- return formattedData;
298
- }
299
- };
300
-
301
- // tracks/hic/data/FirstChrX.ts
302
- var FirstChrX = class {
303
- constructor(chrorder, chrx, chry) {
304
- this.chrorder = chrorder;
305
- this.chrx = chrx;
306
- this.chry = chry;
307
- }
308
- isFirstX() {
309
- if (this.chrx == this.chry) return true;
310
- return this.chrorder.indexOf(this.chrx) < this.chrorder.indexOf(this.chry);
311
- }
312
- };
313
-
314
- // tracks/hic/chrpair/ChrPairView.ts
315
- var ChrPairView = class {
316
- constructor(opts) {
317
- this.binpx = 1;
318
- /** padding on the ends of x/y chr coordinate axes */
319
- this.axispad = 10;
320
- this.axisLabelFontSize = 15;
321
- this.calcResolution = null;
322
- this.data = [];
323
- this.app = opts.app;
324
- this.hic = opts.hic;
325
- this.plotDiv = opts.plotDiv;
326
- this.items = opts.items;
327
- this.parent = opts.parent;
328
- this.chrxlen = this.hic.genome.chrlookup[this.parent("state").x.chr.toUpperCase()].len;
329
- this.chrylen = this.hic.genome.chrlookup[this.parent("state").y.chr.toUpperCase()].len;
330
- this.maxchrlen = Math.max(this.chrxlen, this.chrylen);
331
- this.colorizeElement = new ColorizeElement();
332
- this.positions = new Positions(opts.error, this.parent("state").minBinNum_bp);
333
- this.formattedData = new GridElementsFormattedData();
334
- }
335
- setDefaultBinpx() {
336
- if (this.calcResolution == null) return;
337
- while (this.binpx * this.maxchrlen / this.calcResolution < 600) {
338
- this.binpx++;
339
- }
340
- }
341
- renderAxes() {
342
- if (this.calcResolution == null) return;
343
- const svgY = this.plotDiv.yAxis.append("svg");
344
- const h = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
345
- svgY.attr("width", 100).attr("height", this.axispad * 2 + h);
346
- svgY.append("g").attr("data-testid", "sjpp-chrpair-svg-y").attr("transform", "translate(80," + (this.axispad + h / 2) + ")").append("text").text(this.parent("state").y.chr).attr("text-anchor", "middle").attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("dominant-baseline", "central").attr("transform", "rotate(90)");
347
- axisstyle({
348
- axis: svgY.append("g").attr("transform", `translate(1, ${this.axispad})`).call(axisRight(linear().domain([0, this.chrylen]).range([0, h])).tickFormat(format(".2s"))),
349
- showline: true
350
- });
351
- const svgX = this.plotDiv.xAxis.append("svg").style("margin-top", "-4px");
352
- const w = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
353
- svgX.attr("height", 100).attr("width", this.axispad * 2 + w);
354
- svgX.append("text").attr("data-testid", "sjpp-chrpair-svg-x").text(this.parent("state").x.chr).attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("x", this.axispad + w / 2).attr("text-anchor", "middle").attr("y", 60);
355
- axisstyle({
356
- axis: svgX.append("g").attr("transform", "translate(" + this.axispad + ",1)").call(axisBottom(linear().domain([0, this.chrxlen]).range([0, w])).tickFormat(format(".2s"))),
357
- showline: true
358
- });
359
- }
360
- renderCanvas() {
361
- const initDetailView = this.initDetailView.bind(this);
362
- this.canvas = this.plotDiv.plot.append("canvas").attr("data-testid", "sjpp-chrpair-canvas").style("margin", this.axispad + "px").on("click", async function(event) {
363
- const [x, y] = pointer_default(event, this);
364
- initDetailView(x, y);
365
- }).node();
366
- this.canvas.width = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
367
- this.canvas.height = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
368
- this.ctx = this.canvas.getContext("2d");
369
- }
370
- initDetailView(x, y) {
371
- const [xObj, yObj] = this.positions.setPosition(
372
- x,
373
- y,
374
- this.binpx,
375
- this.parent("state").x,
376
- this.parent("state").y,
377
- this.hic,
378
- this.parent("state").initialBinNum
379
- );
380
- this.app.dispatch({
381
- type: "view_create",
382
- view: "detail",
383
- config: {
384
- x: xObj,
385
- y: yObj
386
- }
387
- });
388
- }
389
- render() {
390
- this.calcResolution = this.parent("calcResolution");
391
- this.setDefaultBinpx();
392
- this.renderAxes();
393
- this.renderCanvas();
394
- this.update(this.items);
395
- }
396
- update(items) {
397
- this.items = items;
398
- const firstisx = new FirstChrX(this.hic.chrorder, this.parent("state").x.chr, this.parent("state").y.chr).isFirstX();
399
- const isintrachr = this.parent("state").x.chr === this.parent("state").y.chr;
400
- this.data = this.formattedData.formatData(
401
- "chrpair",
402
- items.items,
403
- this.binpx,
404
- this.calcResolution,
405
- firstisx,
406
- isintrachr
407
- );
408
- this.ctx.clearRect(0, 0, this.canvas.width, this.canvas.height);
409
- for (const [x, y, v] of this.data) {
410
- this.colorizeElement.colorizeElement(
411
- x,
412
- y,
413
- v,
414
- this.ctx,
415
- this.binpx,
416
- //width
417
- this.binpx,
418
- //height
419
- this.parent("min"),
420
- this.parent("max"),
421
- "chrpair"
422
- );
423
- }
424
- this.app.dispatch({ type: "loading_active", active: false });
425
- }
426
- };
427
-
428
- // tracks/hic/horizontal/HorizontalView.ts
429
- var HorizontalView = class {
430
- constructor(opts) {
431
- /** Defaults*/
432
- this.maxPercentage = 5;
433
- this.subPanelPxWidth = 600;
434
- this.borderColor = "rgba(200,0,0,.1)";
435
- this.app = opts.app;
436
- this.hic = opts.hic;
437
- this.plotDiv = opts.plotDiv;
438
- this.items = opts.items;
439
- this.parent = opts.parent;
440
- }
441
- setRunPpTracks() {
442
- const tracks = [
443
- {
444
- type: "hicstraw",
445
- file: this.hic.file,
446
- url: this.hic.url,
447
- name: this.hic.name,
448
- enzyme: this.hic.enzyme,
449
- maxpercentage: this.maxPercentage,
450
- pyramindup: 1
451
- }
452
- ];
453
- if (this.hic.tklst) {
454
- for (const t of this.hic.tklst) {
455
- tracks.push(t);
456
- }
457
- }
458
- first_genetrack_tolist(this.hic.genome, tracks);
459
- return tracks;
460
- }
461
- setRunPpArgs(tracks) {
462
- const arg = {
463
- holder: this.plotDiv.plot,
464
- hostURL: this.hic.hostURL,
465
- jwt: this.hic.jwt,
466
- genome: this.hic.genome,
467
- nobox: 1,
468
- tklst: tracks
469
- };
470
- const state = this.parent("state");
471
- if (state.x.chr == state.y.chr && Math.max(state.x.start, state.y.start) < Math.min(state.x.stop, state.y.stop)) {
472
- arg["chr"] = state.x.chr;
473
- arg["start"] = Math.min(state.x.start, state.y.start);
474
- arg["stop"] = Math.max(state.x.stop, state.y.stop);
475
- } else {
476
- arg["chr"] = state.x.chr;
477
- arg["start"] = state.x.start;
478
- arg["stop"] = state.x.stop;
479
- arg["width"] = this.subPanelPxWidth;
480
- arg["subpanels"] = [
481
- {
482
- chr: state.y.chr,
483
- start: state.y.start,
484
- stop: state.y.stop,
485
- width: this.subPanelPxWidth,
486
- leftpad: 10,
487
- leftborder: this.borderColor
488
- }
489
- ];
490
- }
491
- return arg;
492
- }
493
- render() {
494
- const tracks = this.setRunPpTracks();
495
- const arg = this.setRunPpArgs(tracks);
496
- blocklazyload(arg);
497
- }
498
- // update() {
499
- // //Not required.
500
- // //If controls are added back. Implement changes here.
501
- // }
502
- };
503
-
504
- // tracks/hic/detail/DetailBlock.ts
505
- var DetailBlock = class {
506
- constructor(app, hic, blockwidth, bbmargin, holder, isYblock) {
507
- /** Defaults */
508
- this.leftheadw = 20;
509
- this.rightheadw = 40;
510
- this.lpad = 1;
511
- this.rpad = 1;
512
- this.firstRender = true;
513
- this.app = app;
514
- this.hic = hic;
515
- this.width = blockwidth;
516
- this.bbmargin = bbmargin;
517
- this.holder = holder;
518
- this.isYblock = isYblock;
519
- this.bbw = this.leftheadw + this.lpad + this.width + this.rpad + this.rightheadw + 2 * this.bbmargin;
520
- this.defaultLeft = this.bbmargin + this.leftheadw + this.lpad;
521
- this.defaultTop = this.bbmargin + this.rightheadw + this.rpad;
522
- }
523
- setArgs(chrObj) {
524
- const runPpArgs = {
525
- hostURL: this.hic.hostURL,
526
- genome: this.hic.genome,
527
- holder: this.holder,
528
- noresize: true,
529
- nobox: true,
530
- butrowbottom: true,
531
- style: {
532
- margin: `${this.bbmargin}px`
533
- },
534
- width: this.width,
535
- leftheadw: this.leftheadw,
536
- chr: chrObj.chr,
537
- start: chrObj.start,
538
- stop: chrObj.stop,
539
- rightheadw: this.rightheadw,
540
- tklst: [],
541
- rotated: this.isYblock,
542
- showreverse: this.isYblock
543
- };
544
- first_genetrack_tolist(this.hic.genome, runPpArgs.tklst);
545
- return runPpArgs;
546
- }
547
- setMethods(canvasHolder, canvas, sheath) {
548
- const runPpMethods = {
549
- onloadalltk_always: () => {
550
- this.onload(canvasHolder, canvas, sheath);
551
- },
552
- onpanning: (xoff) => this.onpanning(xoff, canvas)
553
- };
554
- if (this.isYblock) {
555
- runPpMethods["onsetheight"] = (bbh) => {
556
- this.holder.transition().style("left", `${bbh + this.bbmargin + 30}px`);
557
- };
558
- }
559
- return runPpMethods;
560
- }
561
- onload(canvasHolder, canvas, sheath) {
562
- this.bbw = this.block.leftheadw + this.block.lpad + this.block.width + this.block.rpad + this.block.rightheadw + 2 * this.bbmargin;
563
- if (this.isYblock) {
564
- sheath.transition().style("height", `${this.bbw}px`);
565
- canvasHolder.style("height", `${this.bbw}px`);
566
- } else canvasHolder.style("width", `${this.bbw}px`);
567
- if (this.isYblock) {
568
- this.defaultTop = this.bbmargin + this.block.rightheadw + this.block.rpad;
569
- canvas.style("top", `${this.defaultTop}px`);
570
- } else {
571
- this.defaultLeft = this.bbmargin + this.block.leftheadw + this.block.lpad;
572
- canvas.style("left", `${this.defaultLeft}px`);
573
- }
574
- const config = {
575
- [this.isYblock ? "y" : "x"]: {
576
- chr: this.block.rglst[0].chr,
577
- start: this.block.rglst[0].start,
578
- stop: this.block.rglst[0].stop
579
- }
580
- };
581
- if (this.firstRender == false) {
582
- this.app.dispatch({
583
- type: "view_update",
584
- config
585
- });
586
- } else {
587
- this.firstRender = false;
588
- }
589
- }
590
- onpanning(xoff, canvas) {
591
- if (!this.isYblock) canvas.style("left", `${xoff + this.defaultLeft}px`);
592
- else canvas.style("top", `${-xoff + this.defaultTop}px`);
593
- }
594
- async loadBlock(chrObj, canvasHolder, canvas, sheath) {
595
- const runPpArgs = this.setArgs(chrObj);
596
- const runPpMethods = this.isYblock ? this.setMethods(canvasHolder, canvas, sheath) : this.setMethods(canvasHolder, canvas);
597
- const args = Object.assign(runPpArgs, runPpMethods);
598
- await blocklazyload(args).then(async (block) => {
599
- this.block = block;
600
- });
601
- }
602
- };
603
-
604
- // tracks/hic/data/DetailDataFetcher.ts
605
- var DetailDataFetcher = class {
606
- constructor(errList) {
607
- this.obj = {
608
- rglst: []
609
- };
610
- this.errList = errList;
611
- }
612
- isFragData(hic, resolution) {
613
- if (resolution != null) return;
614
- if (!hic.enzyme) {
615
- resolution = hic.bpresolution[hic.bpresolution.length - 1];
616
- return;
617
- }
618
- }
619
- formatFragArgs(enzymefile, chr) {
620
- const arg = {
621
- getdata: 1,
622
- getBED: 1,
623
- file: enzymefile,
624
- rglst: [chr]
625
- };
626
- return arg;
627
- }
628
- /**
629
- * @param arg Formated obj from either fn above
630
- * @param errList
631
- * @returns
632
- */
633
- async getBedData(arg) {
634
- try {
635
- return await dofetch3("tkbedj", { method: "POST", body: JSON.stringify(arg) });
636
- } catch (e) {
637
- this.errList.push(e.message || e);
638
- if (e.stack) console.error(e.stack);
639
- }
640
- }
641
- async getXFragData(hic, resolution, chrx) {
642
- this.isFragData(hic, resolution);
643
- if (!hic.enzymefile) return;
644
- const reqArgs = this.formatFragArgs(hic.enzymefile, chrx);
645
- return await this.getBedData(reqArgs);
646
- }
647
- async getYFragData(hic, chry) {
648
- const reqArgs = this.formatFragArgs(hic.enzymefile, chry);
649
- return await this.getBedData(reqArgs);
650
- }
651
- /**
652
- * Separate request from data fetch
653
- * Returns the additional fragment data
654
- * @param fragCoords
655
- */
656
- async fetchData(hic, detailView, resolution, x, y, fragCoords) {
657
- const fragStrawArgs = {
658
- matrixType: detailView.matrixType,
659
- file: hic.file,
660
- url: hic.url,
661
- pos1: this.determinePosition(hic, x, fragCoords?.x),
662
- pos2: this.determinePosition(hic, y, fragCoords?.y),
663
- nmeth: detailView.nmeth,
664
- resolution
665
- };
666
- if (fragCoords) fragStrawArgs["isfrag"] = true;
667
- try {
668
- const data = dofetch3("hicdata?", {
669
- method: "POST",
670
- body: JSON.stringify(fragStrawArgs)
671
- });
672
- if (data.error) {
673
- this.errList.push(data.error);
674
- }
675
- return data;
676
- } catch (e) {
677
- this.errList.push(e.message || e);
678
- if (e.stack) console.error(e.stack);
679
- }
680
- }
681
- determinePosition(hic, chr, fragCoord) {
682
- if (fragCoord) {
683
- return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${fragCoord.start}:${fragCoord.stop}`;
684
- } else {
685
- return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${chr.start}:${chr.stop}`;
686
- }
687
- }
688
- };
689
-
690
- // tracks/hic/data/ParseFragData.ts
691
- var ParseFragData = class {
692
- constructor(errLst, items) {
693
- this.id2coord = /* @__PURE__ */ new Map();
694
- this.min = null;
695
- this.max = null;
696
- this.items = [];
697
- this.errLst = errLst;
698
- for (const i of items) {
699
- if (!i.rest || !i.rest[0]) {
700
- this.errLst.push("items[].rest data problem");
701
- }
702
- const id = Number.parseInt(i.rest[0]);
703
- if (Number.isNaN(id)) {
704
- this.errLst.push(`${i.start}.${i.stop} invalid fragment id: ${i.rest[0]}`);
705
- }
706
- this.id2coord.set(id, [i.start, i.stop]);
707
- if (this.min == null) {
708
- this.min = id;
709
- this.max = id;
710
- } else {
711
- this.min = Math.min(this.min, id);
712
- this.max = Math.max(this.max, id);
713
- }
714
- }
715
- }
716
- };
717
-
718
- // tracks/hic/data/DetailDataMapper.ts
719
- var DetailDataMapper = class {
720
- constructor(hic, errList, parent) {
721
- this.frag = {
722
- x: {},
723
- y: {}
724
- };
725
- this.hic = hic;
726
- this.errList = errList;
727
- this.dataFetcher = new DetailDataFetcher(errList);
728
- this.parent = parent;
729
- }
730
- async getFragData(chrx, chry) {
731
- try {
732
- const xFragData = await this.dataFetcher.getXFragData(this.hic, this.parent("calcResolution"), chrx);
733
- if (xFragData) {
734
- if (!xFragData.items) {
735
- this.errList.push(`No fragment data returned for ${chrx.chr}:${chrx.start}-${chrx.stop}`);
736
- return;
737
- }
738
- const xParse = new ParseFragData(this.errList, xFragData.items);
739
- if (this.errList.length) return;
740
- this.frag.x = {
741
- id2coord: xParse.id2coord,
742
- start: xParse.min,
743
- stop: xParse.max
744
- };
745
- const yFragData = await this.dataFetcher.getYFragData(this.hic, chry);
746
- if (this.errList.length) return;
747
- if (yFragData) {
748
- if (!yFragData.items) {
749
- this.errList.push(`No fragment data returned for ${chry.chr}:${chry.start}-${chry.stop}`);
750
- return;
751
- }
752
- const yParse = new ParseFragData(this.errList, yFragData.items);
753
- if (this.errList.length) return;
754
- this.frag.y = {
755
- id2coord: /* @__PURE__ */ new Map(),
756
- start: yParse.min,
757
- stop: yParse.max
758
- };
759
- this.determineMap(yParse.id2coord, chrx, chry);
760
- }
761
- }
762
- } catch (e) {
763
- this.errList.push(e.message || e);
764
- if (e.stack) console.error(e.stack);
765
- }
766
- }
767
- determineMap(map, chrx, chry) {
768
- if (chrx.chr == chry.chr) {
769
- for (const [id, pos] of map) {
770
- this.frag.x["id2coord"].set(id, pos);
771
- }
772
- this.frag.y["id2coord"] = this.frag.x["id2coord"];
773
- } else {
774
- this.frag.y["id2coord"] = map;
775
- }
776
- }
777
- async getData(chrx, chry, fragCoords) {
778
- return await this.dataFetcher.fetchData(
779
- this.hic,
780
- this.parent("state")["detail"],
781
- this.parent("calcResolution"),
782
- chrx,
783
- chry,
784
- fragCoords
785
- );
786
- }
787
- };
788
-
789
- // tracks/hic/data/DetailCoodinates.ts
790
- var DetailCoordinates = class {
791
- constructor(hic, errlist) {
792
- this.hic = hic;
793
- this.errlist = errlist;
794
- }
795
- getCoordinates(chrx, chry, data, resolution, widthHeightPx, fragData) {
796
- const isFirstX = new FirstChrX(this.hic.chrorder, chrx.chr, chry.chr).isFirstX();
797
- const isintrachr = chrx.chr == chry.chr;
798
- const xpxbp = widthHeightPx / (chrx.stop - chrx.start);
799
- const ypxbp = widthHeightPx / (chry.stop - chry.start);
800
- const list = this.calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData);
801
- return list;
802
- }
803
- calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData) {
804
- const list = [];
805
- for (const [xCoord, yCoord, value] of data.items) {
806
- let coord1, coord2, span1, span2;
807
- if (fragData) {
808
- const idx_start = isFirstX ? xCoord : yCoord;
809
- const idy_start = isFirstX ? yCoord : xCoord;
810
- if (fragData.x.id2coord.has(idx_start)) {
811
- const [a, b] = fragData.x.id2coord.get(idx_start);
812
- coord1 = a;
813
- span1 = b - a;
814
- } else {
815
- this.errlist.push(`[x id error] x: ${idx_start} y: ${idy_start}`);
816
- continue;
817
- }
818
- {
819
- const id_stop = idx_start + resolution;
820
- if (fragData.x.id2coord.has(id_stop)) {
821
- const ab = fragData.x.id2coord.get(id_stop);
822
- span1 = ab[1] - coord1;
823
- }
824
- }
825
- if (fragData.y.id2coord.has(idy_start)) {
826
- const [a, b] = fragData.y.id2coord.get(idy_start);
827
- coord2 = a;
828
- span2 = b - a;
829
- } else {
830
- this.errlist.push(`[y id error] x: ${idx_start} y: ${idy_start}`);
831
- continue;
832
- }
833
- {
834
- const id_stop = idy_start + resolution;
835
- if (fragData.y.id2coord.has(id_stop)) {
836
- const ab = fragData.y.id2coord.get(id_stop);
837
- span2 = ab[1] - coord2;
838
- }
839
- }
840
- } else {
841
- coord1 = isFirstX ? xCoord : yCoord;
842
- coord2 = isFirstX ? yCoord : xCoord;
843
- span1 = resolution;
844
- span2 = resolution;
845
- }
846
- if (isintrachr) {
847
- if (coord1 > chrx.start - span1 && coord1 < chrx.stop && coord2 > chry.start - span2 && coord2 < chry.stop) {
848
- list.push([
849
- Math.floor((coord1 - chrx.start) * xpxbp),
850
- Math.floor((coord2 - chry.start) * ypxbp),
851
- Math.ceil(span1 * xpxbp),
852
- Math.ceil(span2 * ypxbp),
853
- value
854
- ]);
855
- }
856
- if (coord2 > chrx.start - span2 && coord2 < chrx.stop && coord1 > chry.start && coord1 < chry.stop) {
857
- list.push([
858
- Math.floor((coord2 - chrx.start) * xpxbp),
859
- Math.floor((coord1 - chry.start) * ypxbp),
860
- Math.ceil(span2 * xpxbp),
861
- Math.ceil(span1 * ypxbp),
862
- value
863
- ]);
864
- }
865
- continue;
866
- }
867
- list.push([
868
- Math.floor((coord1 - chrx.start) * xpxbp),
869
- Math.floor((coord2 - chry.start) * ypxbp),
870
- Math.ceil(span1 * xpxbp),
871
- Math.ceil(span2 * ypxbp),
872
- value
873
- ]);
874
- }
875
- return list;
876
- }
877
- };
878
-
879
- // tracks/hic/detail/DetailView.ts
880
- var DetailView = class {
881
- constructor(opts) {
882
- this.calcResolution = null;
883
- /** Defaults **/
884
- this.binpx = 2;
885
- this.bbmargin = 1;
886
- this.app = opts.app;
887
- this.hic = opts.hic;
888
- this.plotDiv = opts.plotDiv;
889
- this.sheath = opts.plotDiv.yAxis.append("div").style("position", "relative").style("width", "200px").style("height", "800px");
890
- this.rotor = this.sheath.append("div").style("position", "absolute").style("bottom", "0px").style("transform", "rotate(-90deg)").style("transform-origin", "left bottom");
891
- this.data = opts.data;
892
- this.parent = opts.parent;
893
- this.errList = this.parent("errList");
894
- this.resolution = new Resolution(opts.error);
895
- this.colorizeElement = new ColorizeElement();
896
- this.viewRangeBpW = this.resolution.getDefaultViewSpan(
897
- this.hic,
898
- this.parent("state").x,
899
- this.parent("state").y,
900
- this.parent("state").initialBinNum,
901
- this.parent("state").minBinNum_bp
902
- );
903
- this.dataMapper = new DetailDataMapper(this.hic, opts.error, opts.parent);
904
- this.coordinates = new DetailCoordinates(this.hic, this.errList);
905
- }
906
- renderCanvas(blockwidth) {
907
- this.canvasHolder = this.plotDiv.plot.append("div").style("position", "relative").style("width", `${this.xBlock.bbw}px`).style("height", `${this.yBlock.bbw}px`).style("overflow", "hidden");
908
- this.canvas = this.canvasHolder.append("canvas").style("display", "block").style("position", "absolute").attr("data-testid", "sjpp-hic-detail-canvas").attr("width", blockwidth).attr("height", blockwidth).on("mousedown", (event) => {
909
- const body = select_default(document.body);
910
- const x = event.clientX;
911
- const y = event.clientY;
912
- const oldx = Number.parseInt(this.canvas.style("left"));
913
- const oldy = Number.parseInt(this.canvas.style("top"));
914
- body.on("mousemove", (event2) => {
915
- const xoff = event2.clientX - x;
916
- const yoff = event2.clientY - y;
917
- this.xBlock.block.panning(xoff);
918
- this.yBlock.block.panning(yoff);
919
- this.canvas.style("left", `${oldx + xoff}px`).style("top", `${oldy + yoff}px`);
920
- });
921
- body.on("mouseup", (event2) => {
922
- body.on("mousemove", null).on("mouseup", null);
923
- const xoff = event2.clientX - x;
924
- const yoff = event2.clientY - y;
925
- this.xBlock.block.pannedby(xoff);
926
- this.yBlock.block.pannedby(yoff);
927
- });
928
- });
929
- }
930
- async render() {
931
- this.calcResolution = this.parent("calcResolution");
932
- const state = this.parent("state");
933
- this.xBlock = new DetailBlock(
934
- this.app,
935
- this.hic,
936
- state.settings.widthHeightPx,
937
- this.bbmargin,
938
- this.plotDiv.xAxis,
939
- false
940
- );
941
- this.yBlock = new DetailBlock(this.app, this.hic, state.settings.widthHeightPx, this.bbmargin, this.rotor, true);
942
- this.renderCanvas(state.settings.widthHeightPx);
943
- await this.xBlock.loadBlock(state.x, this.canvasHolder, this.canvas);
944
- await this.yBlock.loadBlock(state.y, this.canvasHolder, this.canvas, this.sheath);
945
- this.update(this.data);
946
- }
947
- async update(data) {
948
- if (data.items.length == 0) {
949
- this.app.dispatch({ type: "loading_active", active: false });
950
- return;
951
- }
952
- this.data = data;
953
- const state = this.parent("state");
954
- const initialWidth = Number.parseInt(this.canvas.attr("width"));
955
- const holderChange = Number.parseInt(this.canvasHolder.style("width")) - initialWidth + state.settings.widthHeightPx;
956
- this.canvasHolder.style("width", `${holderChange}px`).style("height", `${holderChange}px`);
957
- this.canvas.attr("width", `${state.settings.widthHeightPx}px`).attr("height", `${state.settings.widthHeightPx}px`);
958
- if (this.xBlock.block.width != state.settings.widthHeightPx) {
959
- this.xBlock.block.width = state.settings.widthHeightPx;
960
- this.yBlock.block.width = state.settings.widthHeightPx;
961
- this.xBlock.block.zoom2px(0, initialWidth);
962
- this.yBlock.block.zoom2px(0, initialWidth);
963
- }
964
- this.ctx = this.canvas.node().getContext("2d");
965
- const coords = this.coordinates.getCoordinates(
966
- state.x,
967
- state.y,
968
- this.parent("data"),
969
- this.parent("calcResolution"),
970
- state.settings.widthHeightPx,
971
- this.parent("fragData")
972
- );
973
- this.coords = coords;
974
- this.ctx.clearRect(0, 0, state.settings.widthHeightPx, state.settings.widthHeightPx);
975
- for (const [xCoord, yCoord, width, height, value] of this.coords) {
976
- this.colorizeElement.colorizeElement(
977
- xCoord,
978
- yCoord,
979
- value,
980
- this.ctx,
981
- width,
982
- height,
983
- this.parent("min"),
984
- this.parent("max"),
985
- "detail"
986
- );
987
- }
988
- this.app.dispatch({ type: "loading_active", active: false });
989
- }
990
- };
991
-
992
- // tracks/hic/axes/Chromosome.ts
993
- var Chromosome = class {
994
- constructor(chr, width) {
995
- this.label = chr;
996
- this.width = width;
997
- }
998
- };
999
-
1000
- // tracks/hic/grid/Grid.ts
1001
- var Grid = class _Grid {
1002
- constructor(chrlst, resolution, chrlookup, binpx) {
1003
- this.chromosomeMatrix = /* @__PURE__ */ new Map();
1004
- this.chromosomeList = [];
1005
- this.xoff = 0;
1006
- this.yoff = 0;
1007
- this.chr2px = [];
1008
- this.chrlst = chrlst;
1009
- let totalpx = this.chrlst.length;
1010
- for (const chr of this.chrlst) {
1011
- const w = Math.ceil(chrlookup[chr.toUpperCase()].len / resolution) * binpx;
1012
- const chromosome = new Chromosome(chr, w);
1013
- this.chromosomeList.push(chromosome);
1014
- this.chr2px[chr] = w;
1015
- totalpx += w;
1016
- }
1017
- this.totalpx = totalpx;
1018
- for (let i = 0; i < this.chrlst.length; i++) {
1019
- const chrx = this.chrlst[i];
1020
- this.chromosomeMatrix.set(chrx, /* @__PURE__ */ new Map());
1021
- let yoff = 0;
1022
- for (let j = 0; j <= i; j++) {
1023
- const chry = this.chrlst[j];
1024
- const chrxChrLen = chrlookup[chrx.toUpperCase()].len;
1025
- const chryChrLen = chrlookup[chry.toUpperCase()].len;
1026
- const xbins = Math.ceil(chrxChrLen / resolution) * binpx;
1027
- const ybins = Math.ceil(chryChrLen / resolution) * binpx;
1028
- this.chromosomeMatrix.get(chrx).set(chry, {
1029
- x: this.xoff,
1030
- y: yoff,
1031
- xbins,
1032
- ybins,
1033
- data: []
1034
- //Empty array of data to fill later
1035
- });
1036
- yoff += this.chr2px[chry] + _Grid.borderWidth;
1037
- }
1038
- this.yoff = yoff;
1039
- this.xoff += this.chr2px[chrx] + _Grid.borderWidth;
1040
- }
1041
- }
1042
- static {
1043
- this.checkerFill = "#DEF3FA";
1044
- }
1045
- static {
1046
- this.spaceColor = "#CCC";
1047
- }
1048
- static {
1049
- this.fontSize = 15;
1050
- }
1051
- static {
1052
- this.font = font;
1053
- }
1054
- static {
1055
- this.borderWidth = 1;
1056
- }
1057
- static {
1058
- this.defaultChrLabWidth = 100;
1059
- }
1060
- };
1061
-
1062
- // tracks/hic/viewmodel/GridViewModel.ts
1063
- var GridViewModel = class {
1064
- constructor(opts) {
1065
- this.grid = new Grid(opts.hic.chrlst, opts.resolution || opts.hic.bpresolution[0], opts.hic.genome.chrlookup, 1);
1066
- }
1067
- };
1068
-
1069
- // tracks/hic/grid/GridRenderer.ts
1070
- var GridRenderer = class {
1071
- constructor(svg, layerMap, layerSv, grid) {
1072
- this.svg = svg;
1073
- this.layerMap = layerMap.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
1074
- this.layerSv = layerSv.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
1075
- this.grid = grid;
1076
- }
1077
- render() {
1078
- this.renderAxisX(this.grid);
1079
- this.renderAxisY(this.grid);
1080
- this.svg.attr("width", Grid.defaultChrLabWidth + this.grid.xoff).attr("height", Grid.fontSize + this.grid.yoff);
1081
- }
1082
- renderAxisX(grid) {
1083
- let xoff = 0;
1084
- this.grid.chromosomeList.forEach((chr, index) => {
1085
- const chrw = chr.width;
1086
- if (index % 2 === 0) {
1087
- this.layerMap.append("rect").attr("x", xoff).attr("width", chrw).attr("height", Grid.fontSize).attr("y", -Grid.fontSize).attr("fill", Grid.checkerFill);
1088
- }
1089
- this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-xAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "middle").attr("font-size", 12).attr("x", xoff + chrw / 2).text(chr.label);
1090
- xoff += chrw;
1091
- this.layerSv.append("line").attr("x1", xoff).attr("x2", xoff).attr("y2", grid.totalpx).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
1092
- xoff += Grid.borderWidth;
1093
- });
1094
- }
1095
- renderAxisY(grid) {
1096
- let yoff = 0;
1097
- this.grid.chromosomeList.forEach((chr, index) => {
1098
- const chrh = chr.width;
1099
- if (index % 2 === 0) {
1100
- this.layerMap.append("rect").attr("x", -Grid.defaultChrLabWidth).attr("width", Grid.defaultChrLabWidth).attr("height", chrh).attr("y", yoff).attr("fill", Grid.checkerFill);
1101
- }
1102
- this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-yAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "end").attr("dominant-baseline", "central").attr("font-size", 12).attr("y", yoff + chrh / 2).text(chr.label);
1103
- yoff += chrh;
1104
- this.layerSv.append("line").attr("x2", grid.totalpx).attr("y1", yoff).attr("y2", yoff).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
1105
- yoff += Grid.borderWidth;
1106
- });
1107
- }
1108
- };
1109
-
1110
- // tracks/hic/genome/ChrsTooltips.ts
1111
- var ChrsTooltips = class {
1112
- constructor() {
1113
- this.chrx_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1114
- this.chry_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1115
- }
1116
- render(img, chrx, chry) {
1117
- const p = img.node().getBoundingClientRect();
1118
- this.chrx_tip.clear().show(p.left, p.top).d.style("top", null).attr("data-testid", "sjpp-hic-chrx-tooltip").style("bottom", window.innerHeight - p.top - window.pageYOffset + "px").text(chrx);
1119
- this.chry_tip.clear().show(p.left, p.top).d.style("left", null).attr("data-testid", "sjpp-hic-chry-tooltip").style("right", document.body.clientWidth - p.left - window.pageXOffset + "px").text(chry);
1120
- }
1121
- };
1122
-
1123
- // tracks/hic/grid/GridElementRenderer.ts
1124
- var GridElementRenderer = class {
1125
- constructor(layerMap, app) {
1126
- this.app = app;
1127
- this.layerMap = layerMap;
1128
- this.tooltips = new ChrsTooltips();
1129
- }
1130
- render(obj, lead, follow, holder) {
1131
- obj.canvas = holder.append("canvas").style("display", "none").node();
1132
- obj.ctx = obj.canvas.getContext("2d");
1133
- obj.canvas.width = obj.xbins;
1134
- obj.canvas.height = obj.ybins;
1135
- obj.img = this.layerMap.append("image").attr("width", obj.canvas.width).attr("height", obj.canvas.height).attr("x", obj.x).attr("y", obj.y).on("click", async () => {
1136
- await this.app.dispatch({
1137
- type: "view_create",
1138
- view: "chrpair",
1139
- config: {
1140
- x: {
1141
- chr: lead
1142
- },
1143
- y: {
1144
- chr: follow
1145
- }
1146
- }
1147
- });
1148
- }).on("mouseover", () => {
1149
- this.tooltips.render(obj.img, lead, follow);
1150
- });
1151
- if (lead != follow) {
1152
- obj.canvas2 = holder.append("canvas").style("display", "none").node();
1153
- obj.canvas2.width = obj.ybins;
1154
- obj.canvas2.height = obj.xbins;
1155
- obj.ctx2 = obj.canvas2.getContext("2d");
1156
- obj.img2 = this.layerMap.append("image").attr("width", obj.canvas2.width).attr("height", obj.canvas2.height).attr("x", obj.y).attr("y", obj.x).on("click", async () => {
1157
- await this.app.dispatch({
1158
- type: "view_create",
1159
- view: "chrpair",
1160
- config: {
1161
- x: {
1162
- chr: follow
1163
- },
1164
- y: {
1165
- chr: lead
1166
- }
1167
- }
1168
- });
1169
- }).on("mouseover", () => {
1170
- this.tooltips.render(obj.img2, follow, lead);
1171
- });
1172
- } else {
1173
- obj.ctx2 = obj.ctx;
1174
- }
1175
- }
1176
- };
1177
-
1178
- // tracks/hic/grid/GridElementsRenderer.ts
1179
- var GridElementsRenderer = class {
1180
- constructor(grid, layerMap, app) {
1181
- this.grid = grid;
1182
- this.gridElementRenderer = new GridElementRenderer(layerMap, app);
1183
- }
1184
- render(holder) {
1185
- for (const [chrx, chryMap] of this.grid.chromosomeMatrix) {
1186
- for (const [chry, gridElem] of chryMap) {
1187
- this.gridElementRenderer.render(gridElem, chrx, chry, holder);
1188
- }
1189
- }
1190
- }
1191
- };
1192
-
1193
- // tracks/hic/genome/GenomeView.ts
1194
- var GenomeView = class {
1195
- constructor(opts) {
1196
- /** Dom */
1197
- this.tip = new Menu();
1198
- this.pica_x = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1199
- this.pica_y = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1200
- /** Data */
1201
- /** px width for each chr */
1202
- this.chr2px = {};
1203
- this.lead2follow = /* @__PURE__ */ new Map();
1204
- this.values = [];
1205
- /** Defaults */
1206
- this.defaultChrLabWidth = 100;
1207
- this.borderwidth = 1;
1208
- this.default_maxVPerc = 5;
1209
- this.fontsize = 15;
1210
- this.xoff = 0;
1211
- this.yoff = 0;
1212
- this.binpx = 1;
1213
- this.atdev_chrnum = 8;
1214
- this.min = 0;
1215
- this.max = 0;
1216
- this.app = opts.app;
1217
- this.hic = opts.hic;
1218
- this.plotDiv = opts.plotDiv;
1219
- this.data = opts.data;
1220
- this.parent = opts.parent;
1221
- this.resolution = opts.resolution || opts.hic.bpresolution[0];
1222
- this.svg = this.plotDiv.plot.append("svg").attr("data-testid", "sjpp-hic-genome-svg");
1223
- this.layer_map = this.svg.append("g").attr("data-testid", "sjpp-hic-layerMap-g");
1224
- this.layer_sv = this.svg.append("g").attr("data-testid", "sjpp-hic-layerSv-g");
1225
- this.colorizeElement = new ColorizeElement();
1226
- this.viewModel = new GridViewModel(opts);
1227
- this.viewRender = new GridRenderer(this.svg, this.layer_map, this.layer_sv, this.viewModel.grid);
1228
- this.gridElementsRenderer = new GridElementsRenderer(this.viewModel.grid, this.layer_map, this.app);
1229
- this.gridFormattedData = new GridElementsFormattedData();
1230
- }
1231
- makeSv() {
1232
- const unknownchr = /* @__PURE__ */ new Set();
1233
- const radius = 8;
1234
- for (const item of this.hic.sv.items) {
1235
- const _o = this.lead2follow.get(item.chr1);
1236
- if (!_o) {
1237
- unknownchr.add(item.chr1);
1238
- continue;
1239
- }
1240
- const obj = _o.get(item.chr2);
1241
- if (!obj) {
1242
- unknownchr.add(item.chr2);
1243
- continue;
1244
- }
1245
- const p1 = item.position1 / this.resolution;
1246
- const p2 = item.position2 / this.resolution;
1247
- this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cx", obj.x + p1).attr("cy", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
1248
- this.tooltipSv(event, item);
1249
- }).on("mouseout", () => {
1250
- this.tip.hide();
1251
- }).on("click", () => {
1252
- this.clickSv(item);
1253
- });
1254
- if (obj.img2) {
1255
- this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle-2").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cy", obj.x + p1).attr("cx", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
1256
- this.tooltipSv(event, item);
1257
- }).on("mouseout", () => {
1258
- this.tip.hide();
1259
- }).on("click", () => {
1260
- this.clickSv(item);
1261
- });
1262
- }
1263
- }
1264
- }
1265
- tooltipSv(event, item) {
1266
- this.tip.clear().show(event.clientX, event.clientY).d.append("div").text(
1267
- item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`
1268
- );
1269
- }
1270
- clickSv(item) {
1271
- const default_svpointspan = 5e5;
1272
- const default_subpanelpxwidth = 600;
1273
- const subpanel_bordercolor = "rgba(200,0,0,.1)";
1274
- const pane = newpane({ x: 100, y: 100 });
1275
- pane.header.text(
1276
- this.hic.name + " " + (item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`)
1277
- );
1278
- const tracks = [
1279
- {
1280
- type: tkt.hicstraw,
1281
- file: this.hic.file,
1282
- enzyme: this.hic.enzyme,
1283
- maxpercentage: this.default_maxVPerc,
1284
- pyramidup: 1,
1285
- name: this.hic.name
1286
- }
1287
- ];
1288
- if (this.hic.tklst) {
1289
- for (const t of this.hic.tklst) {
1290
- tracks.push(t);
1291
- }
1292
- }
1293
- first_genetrack_tolist(this.hic.genome, tracks);
1294
- const arg = {
1295
- holder: pane.body,
1296
- hostURL: this.hic.hostURL,
1297
- jwt: this.hic.jwt,
1298
- genome: this.hic.genome,
1299
- nobox: 1,
1300
- tklst: tracks
1301
- };
1302
- if (item.chr1 == item.chr2 && Math.abs(item.position2 - item.position1) < default_svpointspan * 2) {
1303
- arg.chr = item.chr1;
1304
- const w = Math.abs(item.position2 - item.position1);
1305
- arg.start = Math.max(1, Math.min(item.position1, item.position2) - w);
1306
- arg.stop = Math.min(
1307
- this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
1308
- Math.max(item.position1, item.position2) + w
1309
- );
1310
- } else {
1311
- arg.chr = item.chr1;
1312
- arg.start = Math.max(1, item.position1 - default_svpointspan / 2);
1313
- arg.stop = Math.min(
1314
- this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
1315
- item.position1 + default_svpointspan / 2
1316
- );
1317
- arg.width = default_subpanelpxwidth;
1318
- arg.subpanels = [
1319
- {
1320
- chr: item.chr2,
1321
- start: Math.max(1, item.position2 - default_svpointspan / 2),
1322
- stop: Math.min(
1323
- this.hic.genome.chrlookup[item.chr2.toUpperCase()].len,
1324
- item.position2 + default_svpointspan / 2
1325
- ),
1326
- width: default_subpanelpxwidth,
1327
- leftpad: 10,
1328
- leftborder: subpanel_bordercolor
1329
- }
1330
- ];
1331
- }
1332
- blocklazyload(arg);
1333
- }
1334
- render() {
1335
- this.viewRender.render();
1336
- this.gridElementsRenderer.render(this.hic.holder);
1337
- if (this.hic.sv && this.hic.sv.items) {
1338
- this.makeSv();
1339
- }
1340
- this.update(this.data);
1341
- }
1342
- update(data) {
1343
- this.data = data;
1344
- this.min = this.parent("min");
1345
- this.max = this.parent("max");
1346
- for (const data2 of this.data) {
1347
- if (!this.hic.chrlst.includes(data2.lead) || !this.hic.chrlst.includes(data2.follow)) continue;
1348
- const obj = this.viewModel.grid.chromosomeMatrix.get(data2.lead).get(data2.follow);
1349
- if (!obj) continue;
1350
- obj.ctx.clearRect(0, 0, obj.canvas.width, obj.canvas.height);
1351
- if (obj.canvas2) {
1352
- obj.ctx2.clearRect(0, 0, obj.canvas2.width, obj.canvas.height);
1353
- }
1354
- obj.data = this.gridFormattedData.formatData("genome", data2.items, this.binpx, this.resolution);
1355
- for (const [xPx, yPx, value] of obj.data) {
1356
- this.colorizeElement.colorizeElement(xPx, yPx, value, obj, this.binpx, this.binpx, this.min, this.max, "genome");
1357
- }
1358
- obj.img.attr("xlink:href", obj.canvas.toDataURL());
1359
- if (obj.canvas2) {
1360
- obj.img2.attr("xlink:href", obj.canvas2.toDataURL());
1361
- }
1362
- }
1363
- this.app.dispatch({ type: "loading_active", active: false });
1364
- }
1365
- };
1366
-
1367
- // tracks/hic/controls/NormalizationMethodControl.ts
1368
- var NormalizationMethodControl = class {
1369
- constructor(holder, normalization, defaultNmeth, callback) {
1370
- this.holder = holder;
1371
- this.normalization = normalization;
1372
- this.defaultNmeth = defaultNmeth;
1373
- this.callback = callback;
1374
- }
1375
- render() {
1376
- if (!this.normalization?.length) {
1377
- this.nmethSelect = this.holder.text(this.defaultNmeth);
1378
- } else {
1379
- this.nmethSelect = this.holder.attr("data-testid", "sjpp-hic-nmeth-select").style("margin-right", "10px").append("select").on("change", async () => {
1380
- const nmeth = this.nmethSelect.node().value;
1381
- this.callback(nmeth, "nmeth");
1382
- });
1383
- for (const n of this.normalization) {
1384
- this.nmethSelect.append("option").text(n);
1385
- }
1386
- }
1387
- }
1388
- update(option) {
1389
- const options = this.nmethSelect.node().options;
1390
- if (!options) return;
1391
- const selectedNmeth = Array.from(options).find((o) => o.value === option);
1392
- if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
1393
- selectedNmeth.selected = true;
1394
- }
1395
- };
1396
-
1397
- // tracks/hic/controls/CutoffControl.ts
1398
- var CutoffControl = class {
1399
- constructor(holder, value, callback) {
1400
- this.holder = holder;
1401
- this.value = value;
1402
- this.callback = callback;
1403
- }
1404
- render(opts) {
1405
- const cutoffDiv = this.holder.attr("data-testid", "sjpp-hic-cutoff-control").style("margin-right", "10px").append("input").attr("type", "number").style("width", opts && "width" in opts ? opts.width : "80px").style("margin-left", "0px").attr("type", "number").property("value", this.value).on("keyup", async (event) => {
1406
- if (event.code != "Enter") return;
1407
- const v = event.target.value;
1408
- this.callback(v);
1409
- });
1410
- return cutoffDiv;
1411
- }
1412
- };
1413
-
1414
- // tracks/hic/controls/MatrixTypeControl.ts
1415
- var MatrixTypeControl = class {
1416
- constructor(holder, callback) {
1417
- this.values = [
1418
- { label: "Observed", value: "observed" },
1419
- { label: "Expected", value: "expected" },
1420
- { label: "Observed/Expected", value: "oe" },
1421
- { label: "Log(Observed/Expected)", value: "log(oe)" }
1422
- // TODO: add server side logic to support these options
1423
- // { label: 'Log(Observed + 1)', value: 'log(obs+1)'},
1424
- // { label: 'Observed Pearson', value: 'op'}
1425
- ];
1426
- this.holder = holder;
1427
- this.callback = callback;
1428
- }
1429
- render() {
1430
- this.matrixSelect = this.holder.attr("data-testid", "sjpp-hic-matrix-type-select").style("margin-right", "10px").append("select").on("change", async () => {
1431
- this.callback(this.matrixSelect.node().value, "matrixType");
1432
- });
1433
- for (const matrixType of this.values) {
1434
- this.matrixSelect.append("option").text(matrixType.label).attr("value", matrixType.value);
1435
- }
1436
- }
1437
- update(option) {
1438
- const options = this.matrixSelect.node().options;
1439
- if (!options) return;
1440
- const selectedNmeth = Array.from(options).find((o) => o.value === option);
1441
- if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
1442
- selectedNmeth.selected = true;
1443
- }
1444
- };
1445
-
1446
- // tracks/hic/controls/ControlPanel.ts
1447
- var ControlPanel = class _ControlPanel {
1448
- constructor(opts) {
1449
- this.zoomBlockCallback = (bool) => {
1450
- const detailView = this.parent("detail");
1451
- detailView.xBlock.block.zoomblock(2, bool);
1452
- detailView.yBlock.block.zoomblock(2, bool);
1453
- };
1454
- this.minCallback = (v) => {
1455
- if (Number(v) > Number(this.parent("max"))) {
1456
- this.error("Min cutoff cannot be greater than max cutoff");
1457
- } else {
1458
- this.parent("min", Number(v));
1459
- this.reColorHeatmap();
1460
- this.parent("infoBar").update();
1461
- }
1462
- };
1463
- this.maxCallback = (v) => {
1464
- if (Number(v) < Number(this.parent("min"))) {
1465
- this.error(`Max cutoff cannot be less than min cutoff`);
1466
- } else if (Number(v) < 0) {
1467
- this.error(`Max cutoff cannot be less than 0`);
1468
- } else {
1469
- this.parent("max", Number(v));
1470
- this.reColorHeatmap();
1471
- this.parent("infoBar").update();
1472
- }
1473
- };
1474
- this.reColorHeatmap = () => {
1475
- if (this.parent("activeView") == "genome") {
1476
- const genomeView = this.parent("genome");
1477
- const chrMatrix = genomeView.viewRender.grid.chromosomeMatrix;
1478
- if (!chrMatrix) return;
1479
- for (const map of chrMatrix) {
1480
- const yMap = map[1];
1481
- for (const obj of yMap) {
1482
- const canvasObj = obj[1];
1483
- if (!canvasObj) continue;
1484
- for (const [leadpx, followpx, val] of canvasObj.data) {
1485
- this.colorizeElement.colorizeElement(
1486
- leadpx,
1487
- followpx,
1488
- val,
1489
- canvasObj,
1490
- 1,
1491
- 1,
1492
- this.parent("min"),
1493
- this.parent("max"),
1494
- "genome"
1495
- );
1496
- }
1497
- canvasObj.img.attr("xlink:href", canvasObj.canvas.toDataURL());
1498
- if (canvasObj.canvas2) {
1499
- canvasObj.img2.attr("xlink:href", canvasObj.canvas2.toDataURL());
1500
- }
1501
- }
1502
- }
1503
- } else if (this.parent("activeView") == "chrpair") {
1504
- const view = this.parent("chrpair");
1505
- for (const [xCoord, yCoord, val] of view.data) {
1506
- this.colorizeElement.colorizeElement(
1507
- xCoord,
1508
- yCoord,
1509
- val,
1510
- view.ctx,
1511
- view.binpx,
1512
- view.binpx,
1513
- this.parent("min"),
1514
- this.parent("max"),
1515
- "chrpair"
1516
- );
1517
- }
1518
- } else if (this.parent("activeView") == "detail") {
1519
- const view = this.parent("detail");
1520
- for (const [xCoord, yCoord, width, height, value] of view.coords) {
1521
- this.colorizeElement.colorizeElement(
1522
- xCoord,
1523
- yCoord,
1524
- value,
1525
- view.ctx,
1526
- width,
1527
- height,
1528
- this.parent("min"),
1529
- this.parent("max"),
1530
- "detail"
1531
- );
1532
- }
1533
- }
1534
- };
1535
- this.dropdownCallback = (v, prop) => {
1536
- const state = this.app.getState();
1537
- this.app.dispatch({
1538
- type: "view_update",
1539
- view: state.currView,
1540
- config: { [prop]: v }
1541
- });
1542
- };
1543
- this.type = _ControlPanel.type;
1544
- this.controls = {};
1545
- this.app = opts.app;
1546
- this.controlsDiv = opts.controlsDiv;
1547
- this.hic = opts.hic;
1548
- this.colorizeElement = new ColorizeElement();
1549
- this.parent = opts.parent;
1550
- this.error = opts.error;
1551
- }
1552
- static {
1553
- this.type = "controlPanel";
1554
- }
1555
- getState(appState) {
1556
- return appState;
1557
- }
1558
- addLabel(tr, text) {
1559
- return tr.append("td").style("color", "#858585").style("font-size", ".8em").style("vertical-align", text.toUpperCase() == "VIEW" ? "top" : "middle").text(text.toUpperCase());
1560
- }
1561
- init() {
1562
- const state = this.app.getState();
1563
- const menuWrapper = this.controlsDiv.attr("data-testid", "sjpp-hic-control-panel").style("background", "rgb(253, 250, 244)").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc");
1564
- let menuVisible = true;
1565
- this.controlsDiv.append("button").attr("data-testid", "sjpp-hic-burger-btn").style("display", "block").style("border", "none").style("font-size", "1.5em").style("background", "none").html("&#8801;").on("click", () => {
1566
- menuVisible = !menuVisible;
1567
- menu.style("display", menuVisible ? "block" : "none");
1568
- });
1569
- const menu = menuWrapper.append("div").attr("class", "sjpp-hic-menu").attr("data-testid", "sjpp-hic-menu").style("display", menuVisible ? "block" : "none");
1570
- const menuTable = menu.append("table").style("border-spacing", "3px");
1571
- this.controls.normalizationRow = menuTable.append("tr");
1572
- this.addLabel(this.controls.normalizationRow, "NORMALIZATION");
1573
- this.controls.nmeth = new NormalizationMethodControl(
1574
- this.controls.normalizationRow.append("td").attr("class", "sjpp-nmeth-select"),
1575
- this.hic.normalization,
1576
- state.defaultNmeth,
1577
- this.dropdownCallback
1578
- );
1579
- this.controls.nmeth.render();
1580
- this.controls.minCutoffRow = menuTable.append("tr");
1581
- this.controls.minCutoffLabel = this.addLabel(this.controls.minCutoffRow, "");
1582
- this.controls.inputBpMinV = new CutoffControl(
1583
- this.controls.minCutoffRow.append("td"),
1584
- this.parent("min"),
1585
- this.minCallback
1586
- ).render({ width: "120px" });
1587
- this.controls.maxCutoffRow = menuTable.append("tr");
1588
- this.controls.maxCutoffLabel = this.addLabel(this.controls.maxCutoffRow, "");
1589
- this.controls.inputBpMaxV = new CutoffControl(
1590
- this.controls.maxCutoffRow.append("td"),
1591
- this.parent("max"),
1592
- this.maxCallback
1593
- ).render({ width: "120px" });
1594
- this.controls.matrixTypeRow = menuTable.append("tr");
1595
- this.addLabel(this.controls.matrixTypeRow, "matrix type");
1596
- this.controls.matrixType = new MatrixTypeControl(this.controls.matrixTypeRow.append("td"), this.dropdownCallback);
1597
- this.controls.matrixType.render();
1598
- this.controls.widthRow = menuTable.append("tr");
1599
- this.addLabel(this.controls.widthRow, "WIDTH / height");
1600
- this.controls.width = this.controls.widthRow.append("td");
1601
- this.controls.width.attr("data-testid", "sjpp-hic-block-size-input").style("margin-right", "10px").append("input").attr("type", "number").style("width", "80px").style("margin-left", "0px").attr("type", "number").property("value", state.width).on("keyup", async (event) => {
1602
- if (event.code != "Enter") return;
1603
- const v = event.target.value;
1604
- this.app.dispatch({
1605
- type: "view_update",
1606
- config: {
1607
- settings: { widthHeightPx: Number.parseInt(v) }
1608
- }
1609
- });
1610
- });
1611
- const viewRow = menuTable.append("tr");
1612
- this.addLabel(viewRow, "VIEW");
1613
- const viewBtnDiv = viewRow.append("td");
1614
- this.controls.view = viewBtnDiv.append("span").attr("data-testid", "sjpp-hic-view-span").style("padding-right", "5px").style("display", "block");
1615
- this.controls.genomeViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-genome-view-btn").style("display", "none").style("padding", "2px").style("margin-top", "4px").html("&#8810; Genome").on("click", async () => {
1616
- await this.app.dispatch({
1617
- type: "view_create",
1618
- view: "genome",
1619
- config: {
1620
- x: {},
1621
- y: {}
1622
- }
1623
- });
1624
- });
1625
- this.controls.chrpairViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-chrpair-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").on("click", async () => {
1626
- const currState = this.app.getState();
1627
- await this.app.dispatch({
1628
- type: "view_create",
1629
- view: "chrpair",
1630
- config: {
1631
- x: {
1632
- chr: currState.x.chr
1633
- },
1634
- y: {
1635
- chr: currState.y.chr
1636
- }
1637
- }
1638
- });
1639
- });
1640
- this.controls.horizontalViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-horizontal-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("Horizontal View &#8811;").on("click", async () => {
1641
- await this.app.dispatch({
1642
- type: "view_create",
1643
- view: "horizontal"
1644
- });
1645
- });
1646
- this.controls.detailViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-detail-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("&#8810; Detailed View").on("click", async () => {
1647
- await this.app.dispatch({
1648
- type: "view_create",
1649
- view: "detail"
1650
- });
1651
- });
1652
- this.controls.zoomDiv = menuTable.append("tr").attr("data-testid", "sjpp-hic-zoom-div").style("display", state.currView == "detail" ? "contents" : "none");
1653
- this.addLabel(this.controls.zoomDiv, "ZOOM");
1654
- const zoomDiv = this.controls.zoomDiv.append("td");
1655
- this.controls.zoomIn = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-in-btn").style("margin-right", "10px").text("In").on("click", () => {
1656
- this.zoomBlockCallback(false);
1657
- });
1658
- this.controls.zoomOut = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-out-btn").style("margin-right", "10px").text("Out").on("click", () => {
1659
- this.zoomBlockCallback(true);
1660
- });
1661
- }
1662
- showBtns() {
1663
- const state = this.app.getState();
1664
- this.controls.genomeViewBtn.style("display", state.currView === "genome" ? "none" : "inline-block");
1665
- if (state.currView === "detail") {
1666
- this.controls.chrpairViewBtn.html(`&#8810; Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
1667
- this.controls.horizontalViewBtn.style("display", "block");
1668
- this.controls.zoomDiv.style("display", "contents");
1669
- this.controls.detailViewBtn.style("display", "none");
1670
- } else if (state.currView === "horizontal") {
1671
- this.controls.chrpairViewBtn.html(`&#8810; Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
1672
- this.controls.detailViewBtn.style("display", "block");
1673
- this.controls.horizontalViewBtn.style("display", "none");
1674
- this.controls.zoomDiv.style("display", "none");
1675
- } else {
1676
- this.controls.chrpairViewBtn.style("display", "none");
1677
- this.controls.horizontalViewBtn.style("display", "none");
1678
- this.controls.detailViewBtn.style("display", "none");
1679
- this.controls.zoomDiv.style("display", "none");
1680
- this.controls.widthRow.style("display", "none");
1681
- }
1682
- }
1683
- showHideControls() {
1684
- const state = this.app.getState();
1685
- this.controls.normalizationRow.style("display", state.currView == "horizontal" ? "none" : "");
1686
- this.controls.minCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
1687
- this.controls.maxCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
1688
- this.controls.matrixTypeRow.style("display", state.currView == "horizontal" ? "none" : "");
1689
- this.controls.widthRow.style("display", state.currView == "detail" ? "contents" : "none");
1690
- }
1691
- main(appState) {
1692
- const state = this.app.getState(appState);
1693
- this.controls.nmeth.update(state[state.currView].nmeth);
1694
- this.controls.matrixType.update(state[state.currView].matrixType);
1695
- this.controls.zoomDiv.style("display", state.currView == "detail" ? "contents" : "none");
1696
- if (state.currView == "chrpair") {
1697
- this.controls.view.text(`${state.x.chr}-${state.y.chr} Pair`);
1698
- } else {
1699
- this.controls.view.text(state.currView.charAt(0).toUpperCase() + state.currView.slice(1));
1700
- }
1701
- const formatAbsMin = this.parent("absMin") < 1e-5 ? Number(this.parent("absMin")).toExponential(1) : Number(this.parent("absMin").toFixed(6));
1702
- const formatAbsMax = this.parent("absMax") < 1e-5 ? Number(this.parent("absMax")).toExponential(1) : Number(this.parent("absMax").toFixed(6));
1703
- this.controls.width.select("input").property("value", state.settings.widthHeightPx);
1704
- this.controls.inputBpMinV.property("value", this.parent("min"));
1705
- this.controls.inputBpMaxV.property("value", this.parent("max"));
1706
- this.controls.minCutoffLabel.html(`MIN CUTOFF <br>(>= ${formatAbsMin})`);
1707
- this.controls.maxCutoffLabel.html(`MAX CUTOFF <br>(<= ${formatAbsMax})`);
1708
- this.showBtns();
1709
- this.showHideControls();
1710
- }
1711
- };
1712
- var controlPanelInit = getCompInit(ControlPanel);
1713
-
1714
- // tracks/hic/dom/InfoBar.ts
1715
- var InfoBar = class {
1716
- constructor(opts) {
1717
- /** Defaults **/
1718
- //Color shown on the left of the color scale
1719
- this.startColor = "white";
1720
- //Color shown on the right of the color scale
1721
- this.endColor = "red";
1722
- this.addLabel = (text) => {
1723
- return this.labelRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toLowerCase().replace(/\s/g, "-")}-label`).style("color", "#858585").style("font-size", ".8em").style("text-align", "center").style("vertical-align", "middle").text(text.toUpperCase());
1724
- };
1725
- this.addValue = (text) => {
1726
- return this.valueRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toString().toLowerCase().replace(/\s/g, "-")}-value`).style("font-size", "1em").style("text-align", "center").style("vertical-align", "middle").text(text);
1727
- };
1728
- this.type = "infoBar";
1729
- this.app = opts.app;
1730
- this.hic = opts.hic;
1731
- const table = opts.infoBarDiv;
1732
- this.labelRow = table.append("tr");
1733
- this.valueRow = table.append("tr");
1734
- this.parent = opts.parent;
1735
- }
1736
- async render() {
1737
- this.addLabel("Version");
1738
- this.addValue(this.hic.version);
1739
- this.addLabel("Enzyme");
1740
- this.addValue(this.hic.enzyme || "N/A");
1741
- this.addLabel("Resolution");
1742
- this.resolutionDiv = this.addValue("");
1743
- this.colorScaleLabel = this.addLabel("Scale");
1744
- this.colorScaleDiv = this.valueRow.append("td").attr("data-testid", "sjpp-hic-color-scale");
1745
- const min = this.parent("min");
1746
- let max = this.parent("max");
1747
- if (min == max) max = max + 0.01;
1748
- this.colorScale = new ColorScale({
1749
- barheight: 20,
1750
- barwidth: 100,
1751
- domain: [min, max],
1752
- fontSize: 12,
1753
- height: 40,
1754
- width: 150,
1755
- holder: this.colorScaleDiv,
1756
- colors: [this.startColor, this.endColor],
1757
- position: "20,0",
1758
- ticks: 3,
1759
- tickSize: 5,
1760
- //Do not use min value here on initialization. It's 0 and will not update later.
1761
- markedValue: 1
1762
- });
1763
- }
1764
- update() {
1765
- const res = this.parent("calcResolution");
1766
- let resolutionText;
1767
- if (res < this.hic.bpresolution[this.hic.bpresolution.length - 1]) {
1768
- resolutionText = `${res} fragment${res > 1 ? "s" : ""}`;
1769
- } else {
1770
- resolutionText = bplen(res);
1771
- }
1772
- this.resolutionDiv.text(resolutionText);
1773
- if (this.parent("state").currView == "horizontal") {
1774
- this.colorScaleLabel.style("display", "none");
1775
- this.colorScaleDiv.style("display", "none");
1776
- } else {
1777
- this.colorScaleLabel.style("display", "");
1778
- this.colorScaleDiv.style("display", "");
1779
- const min = this.parent("min");
1780
- const max = this.parent("max");
1781
- if (min < 0) {
1782
- this.colorScale.colors = ["blue", "white", "red"];
1783
- this.colorScale.domain = [min, 0, max];
1784
- } else {
1785
- this.colorScale.colors = ["white", "red"];
1786
- this.colorScale.domain = [0, max];
1787
- }
1788
- this.colorScale.markedValue = min;
1789
- this.colorScale.updateScale();
1790
- }
1791
- }
1792
- };
1793
-
1794
- // tracks/hic/data/DataMapper.ts
1795
- var DataMapper = class {
1796
- constructor(hic, percentile) {
1797
- this.hic = hic;
1798
- this.percentile = percentile ? percentile / 100 : 0.99;
1799
- }
1800
- sortData(data) {
1801
- const vlst = [];
1802
- if (data?.items && data?.items.length) {
1803
- for (const i of data.items) {
1804
- vlst.push(i[2]);
1805
- }
1806
- } else {
1807
- const blankChrs = /* @__PURE__ */ new Set();
1808
- for (const d of data) {
1809
- if (d.lead == "chrM" && !d.items.length || d.lead == "chrY" && !d.items.length) {
1810
- blankChrs.add(d.lead);
1811
- continue;
1812
- }
1813
- for (const i of d.items) {
1814
- vlst.push(i[2]);
1815
- }
1816
- }
1817
- if (blankChrs.size) {
1818
- for (const c of blankChrs) {
1819
- const idx = this.hic.chrlst.indexOf(c);
1820
- this.hic.chrlst.splice(idx, 1);
1821
- }
1822
- }
1823
- }
1824
- const sortedVlst = vlst.sort((a, b) => a - b);
1825
- const max = sortedVlst[Math.floor(sortedVlst.length * this.percentile)];
1826
- const min = sortedVlst[0];
1827
- return [min, max, sortedVlst[sortedVlst.length - 1]];
1828
- }
1829
- };
1830
-
1831
- // tracks/hic/data/GenomeDataFetcher.ts
1832
- var GenomeDataFetcher = class {
1833
- constructor(hic, debugmode, errList = []) {
1834
- this.data = [];
1835
- this.hic = hic;
1836
- this.debugmode = debugmode;
1837
- this.errList = errList || [];
1838
- }
1839
- async getData(obj) {
1840
- if (this.data.length) this.data = [];
1841
- if (!obj?.matrixType) obj.matrixType = "observed";
1842
- try {
1843
- const res = await dofetch3("hicgenome?", {
1844
- method: "POST",
1845
- body: JSON.stringify({
1846
- chrlst: this.hic.chrlst,
1847
- nmeth: obj.nmeth,
1848
- resolution: obj.resolution,
1849
- matrixType: obj.matrixType,
1850
- file: this.hic.file,
1851
- url: this.hic.url,
1852
- nochr: this.hic.nochr
1853
- })
1854
- });
1855
- if (res.error) {
1856
- const errs = res.error.split("\n");
1857
- for (const e of errs) {
1858
- this.errList.push(e);
1859
- }
1860
- }
1861
- return res.data;
1862
- } catch (e) {
1863
- this.errList.push(e.message || e);
1864
- if (e.stack) console.error(e.stack);
1865
- }
1866
- }
1867
- };
1868
-
1869
- // tracks/hic/data/DataFetcher.ts
1870
- var DataFetcher = class {
1871
- constructor(hic, debugmode, errList = []) {
1872
- this.hic = hic;
1873
- this.debugmode = debugmode;
1874
- this.errList = errList || [];
1875
- }
1876
- async getData(obj) {
1877
- if (!obj?.matrixType) obj.matrixType = "observed";
1878
- const arg = {
1879
- matrixType: obj.matrixType,
1880
- file: this.hic.file,
1881
- url: this.hic.url,
1882
- pos1: this.hic.nochr ? obj.lead.replace("chr", "") : obj.lead,
1883
- pos2: this.hic.nochr ? obj.follow.replace("chr", "") : obj.follow,
1884
- nmeth: obj.nmeth,
1885
- resolution: obj.resolution
1886
- };
1887
- try {
1888
- const data = await dofetch3("hicdata?", {
1889
- method: "POST",
1890
- body: JSON.stringify(arg)
1891
- });
1892
- if (data.error) {
1893
- throw Error(`${obj.lead} - ${obj.follow}: ${data.error.error}`);
1894
- }
1895
- if (!data.items || data.items.length == 0) return;
1896
- return data;
1897
- } catch (e) {
1898
- this.errList.push(e.message || e);
1899
- if (e.stack) console.error(e.stack);
1900
- }
1901
- }
1902
- };
1903
-
1904
- // tracks/hic/HicComponent.ts
1905
- var HicComponent = class _HicComponent {
1906
- constructor(opts) {
1907
- this.genomeData = [];
1908
- this.calcResolution = null;
1909
- this.firstRender = true;
1910
- this.min = 0;
1911
- this.absMin = 0;
1912
- this.max = 0;
1913
- this.absMax = 0;
1914
- this.hasStatePreMain = true;
1915
- this.type = _HicComponent.type;
1916
- this.hic = opts.hic;
1917
- this.state = opts.state;
1918
- this.dom = opts.dom;
1919
- this.errList = opts.errList;
1920
- this.plotDiv = this.dom.plotDiv.append("table").classed("sjpp-hic-plot-main", true);
1921
- const tr1 = this.plotDiv.append("tr");
1922
- const tr2 = this.plotDiv.append("tr");
1923
- this.plotDiv = {
1924
- plot: tr1.append("td").classed("sjpp-hic-plot", true).attr("data-testid", "sjpp-hic-plot"),
1925
- yAxis: tr1.append("td").classed("sjpp-hic-plot-yaxis", true).attr("data-testid", "sjpp-hic-yaxis"),
1926
- xAxis: tr2.append("td").classed("sjpp-hic-plot-xaxis", true).attr("data-testid", "sjpp-hic-xaxis"),
1927
- blank: tr2.append("td")
1928
- };
1929
- this.app = opts.app;
1930
- this.dataMapper = new DataMapper(this.hic, opts.state.maxCutoffPercentile);
1931
- this.activeView = this.state.currView;
1932
- this.error = opts.error;
1933
- this.resolution = new Resolution(this.error);
1934
- this.parent = (prop) => {
1935
- return this[prop];
1936
- };
1937
- this.detailDataMapper = new DetailDataMapper(this.hic, this.errList, this.parent);
1938
- }
1939
- static {
1940
- this.type = "view";
1941
- }
1942
- getState(appState) {
1943
- return appState;
1944
- }
1945
- reactsTo(action) {
1946
- if (action.type.startsWith("view")) return true;
1947
- else return false;
1948
- }
1949
- initView() {
1950
- const opts = {
1951
- plotDiv: this.plotDiv,
1952
- hic: this.hic,
1953
- app: this.app,
1954
- parent: (prop) => {
1955
- return this[prop];
1956
- }
1957
- };
1958
- if (this.state.currView == "genome") {
1959
- opts["data"] = this.data;
1960
- this.genome = new GenomeView(opts);
1961
- this.genome.render();
1962
- } else if (this.state.currView === "chrpair") {
1963
- opts["items"] = this.data;
1964
- this.chrpair = new ChrPairView(opts);
1965
- this.chrpair.render();
1966
- } else if (this.state.currView === "detail") {
1967
- opts["data"] = this.data;
1968
- this.detail = new DetailView(opts);
1969
- this.detail.render();
1970
- } else if (this.state.currView === "horizontal") {
1971
- this.horizontal = new HorizontalView(opts);
1972
- this.horizontal.render();
1973
- } else {
1974
- throw Error(`Unknown view: ${this.state.currView}`);
1975
- }
1976
- }
1977
- async fetchData(obj) {
1978
- if (this.data?.length) this.data = [];
1979
- if (this.state.currView == "genome") {
1980
- if (this.activeView != "genome" && this.genomeData?.length) this.data = this.genomeData;
1981
- else {
1982
- const genomeFetcher = new GenomeDataFetcher(this.hic, true, this.errList);
1983
- this.genomeData = await genomeFetcher.getData(obj);
1984
- this.data = this.genomeData;
1985
- }
1986
- } else if (this.state.currView == "detail") {
1987
- this.data = await this.detailDataMapper.getData(this.state.x, this.state.y, this.fragData);
1988
- } else {
1989
- if (!this.state?.x?.chr || !this.state?.y?.chr) {
1990
- this.errList.push(`No positions provided for ${this.activeView} view.`);
1991
- return;
1992
- } else {
1993
- const chrx = this.state.x;
1994
- const chry = this.state.y;
1995
- obj["lead"] = `${chrx.start && chrx.stop ? `${chrx.chr}:${chrx.start}-${chrx.stop}` : chrx.chr}`;
1996
- obj["follow"] = `${chry.start && chry.stop ? `${chry.chr}:${chry.start}-${chry.stop}` : chry.chr}`;
1997
- }
1998
- const dataFetcher = new DataFetcher(this.hic, true, this.errList);
1999
- this.data = await dataFetcher.getData(obj);
2000
- }
2001
- }
2002
- async setResolution(appState) {
2003
- const state = this.app.getState(appState);
2004
- this.calcResolution = this.resolution.getResolution(state, this.hic);
2005
- if (state.currView == "detail" && this.calcResolution == null) {
2006
- await this.detailDataMapper.getFragData(state.x, state.y);
2007
- this.fragData = this.detailDataMapper.frag;
2008
- const maxFragSpan = Math.min(
2009
- this.fragData.x.stop - this.fragData.x.start,
2010
- this.fragData.y.stop - this.fragData.y.start
2011
- );
2012
- this.calcResolution = this.resolution.findResFromArray(
2013
- maxFragSpan,
2014
- state.minFragSpan,
2015
- this.hic.fragresolution,
2016
- true
2017
- );
2018
- } else {
2019
- this.fragData = null;
2020
- }
2021
- return this.calcResolution;
2022
- }
2023
- async setDataArgs(appState) {
2024
- const state = this.app.getState(appState);
2025
- const currView = state[state.currView];
2026
- const args = {
2027
- nmeth: currView.nmeth,
2028
- resolution: await this.setResolution(appState),
2029
- matrixType: currView.matrixType
2030
- };
2031
- if (state.currView == "chrpair") {
2032
- args["lead"] = state.x.chr;
2033
- args["follow"] = state.y.chr;
2034
- }
2035
- return args;
2036
- }
2037
- async getViewData(appState) {
2038
- const args = await this.setDataArgs(appState);
2039
- await this.fetchData(args);
2040
- if (this.data?.length > 0 || this.data?.items?.length > 0) {
2041
- const [min, max, absMax] = this.dataMapper.sortData(this.data);
2042
- this.min = this.absMin = min;
2043
- this.max = max;
2044
- this.absMax = absMax;
2045
- } else {
2046
- if (this.state.currView != "genome") {
2047
- const state = this.app.getState(appState);
2048
- const xPosMessage = state.x?.start ? `${state.x.chr}:${state.x.start}-${state.x.stop}` : state.x.chr;
2049
- const yPosMessage = state.y?.start ? `${state.y.chr}:${state.y.start}-${state.y.stop}` : state.y.chr;
2050
- this.errList.push(`No data returned for ${xPosMessage} and ${yPosMessage}`);
2051
- }
2052
- }
2053
- }
2054
- async init() {
2055
- this.components = {
2056
- controls: await controlPanelInit({
2057
- app: this.app,
2058
- controlsDiv: this.dom.controlsDiv,
2059
- hic: this.hic,
2060
- parent: (prop, value) => {
2061
- if (value) this[prop] = value;
2062
- return this[prop];
2063
- },
2064
- error: this.error.bind(this)
2065
- })
2066
- };
2067
- this.infoBar = new InfoBar({
2068
- app: this.app,
2069
- infoBarDiv: this.dom.infoBarDiv.append("table").style("border-spacing", "3px"),
2070
- hic: this.hic,
2071
- parent: (prop) => {
2072
- return this[prop];
2073
- }
2074
- });
2075
- this.infoBar.render();
2076
- }
2077
- async main(appState) {
2078
- if (this.errList.length) {
2079
- this.app.dispatch({ type: "loading_active", active: false });
2080
- return;
2081
- }
2082
- const state = this.app.getState(appState);
2083
- if (this.firstRender == true) {
2084
- this.firstRender = false;
2085
- await this.getViewData(appState);
2086
- this.initView();
2087
- } else {
2088
- if (state.currView != "horizontal") {
2089
- this.app.dispatch({ type: "loading_active", active: true });
2090
- await this.getViewData(appState);
2091
- }
2092
- if (this.activeView != state.currView) {
2093
- if (this.activeView == "genome") {
2094
- this.genome.svg.remove();
2095
- } else {
2096
- this.plotDiv.xAxis.selectAll("*").remove();
2097
- this.plotDiv.yAxis.selectAll("*").remove();
2098
- this.plotDiv.plot.selectAll("*").remove();
2099
- }
2100
- this.activeView = state.currView;
2101
- this.initView();
2102
- } else {
2103
- this[state.currView].update(this.data);
2104
- }
2105
- }
2106
- this.infoBar.update();
2107
- if (this.errList.length) {
2108
- this.error(this.errList);
2109
- this.app.dispatch({ type: "loading_active", active: false });
2110
- }
2111
- }
2112
- };
2113
- var viewCompInit = getCompInit(HicComponent);
2114
-
2115
- // tracks/hic/HicApp.ts
2116
- var HicApp = class _HicApp extends AppBase {
2117
- constructor(opts) {
2118
- super(opts);
2119
- this.views = ["genome", "chrpair", "detail", "horizontal"];
2120
- this.errList = [];
2121
- /** Required for rx but not in use */
2122
- this.wasDestroyed = false;
2123
- this.type = _HicApp.type;
2124
- this.hic = {
2125
- enzyme: opts.enzyme,
2126
- file: opts.file,
2127
- url: opts.url,
2128
- genome: opts.genome,
2129
- holder: opts.holder,
2130
- hostUrl: opts.hostUrl,
2131
- jwt: opts.jwt,
2132
- position1: opts.position1,
2133
- position2: opts.position2,
2134
- maxCutoffPercentile: opts.maxCutoffPercentile,
2135
- name: "name" in opts ? opts.name : "Hi-C",
2136
- tklist: "tklst" in opts ? opts.tklst : [],
2137
- state: "state" in opts ? opts.state : {}
2138
- };
2139
- this.dom = {
2140
- errorDiv: opts.holder.append("div").classed("sjpp-hic-error", true),
2141
- controlsDiv: opts.holder.append("div").classed("sjpp-hic-controls", true).style("display", "inline-block"),
2142
- infoBarDiv: opts.holder.append("div").classed("sjpp-hic-infobar", true).style("display", "inline-block").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc"),
2143
- loadingDiv: select_default("body").append("div").attr("id", "sjpp-loading-overlay"),
2144
- plotDiv: opts.holder.append("div").classed("sjpp-hic-main", true).style("display", "inline-block"),
2145
- tip: new Menu()
2146
- };
2147
- }
2148
- static {
2149
- this.type = "app";
2150
- }
2151
- async error(err) {
2152
- if (err && typeof err == "string") this.errList.push(err);
2153
- showErrorsWithCounter(this.errList, this.dom.errorDiv);
2154
- this.errList = [];
2155
- }
2156
- determineView() {
2157
- if (!this.hic.position1 && !this.hic.position2 && !this.hic.state.currView) this.hic.state.currView = "genome";
2158
- if (!this.hic.position1 && this.hic.position2) this.errList.push("Missing first position");
2159
- if (this.hic.position1 && !this.hic.position2) this.errList.push("Missing second position");
2160
- if (this.hic.position1 && this.hic.position2) {
2161
- const pos1 = this.hic.position1.split(/[:-]/);
2162
- const pos2 = this.hic.position2.split(/[:-]/);
2163
- this.hic.state.x = { chr: pos1[0] };
2164
- this.hic.state.y = { chr: pos2[0] };
2165
- if (!Number.isNaN(+pos1[1]) && !Number.isNaN(+pos1[2])) {
2166
- this.hic.state.x.start = +pos1[1];
2167
- this.hic.state.x.stop = +pos1[2];
2168
- this.hic.state.y.start = +pos2[1];
2169
- this.hic.state.y.stop = +pos2[2];
2170
- this.hic.state.currView = "detail";
2171
- } else {
2172
- this.hic.state.currView = "chrpair";
2173
- }
2174
- } else {
2175
- if (!this.views.some((v) => v === this.hic.state.currView)) this.error(`Unknown view: ${this.hic.state.currView}`);
2176
- else return this.hic.state.currView;
2177
- }
2178
- }
2179
- getViewsConfig() {
2180
- if (this.hic.maxCutoffPercentile) this.hic.state.maxCutoffPercentile = this.hic.maxCutoffPercentile;
2181
- let nmeth;
2182
- if (this.hic["normalization"]?.length > 0) {
2183
- if (!this.hic["normalization"].includes("NONE")) this.hic["normalization"].unshift("NONE");
2184
- nmeth = this.hic["normalization"][0];
2185
- } else {
2186
- nmeth = "NONE";
2187
- }
2188
- if (this.hic.state.currView) {
2189
- if (!this.hic.state[this.hic.state.currView]) this.hic.state[this.hic.state.currView] = {};
2190
- if (!this.hic.state[this.hic.state.currView]?.matrixType) {
2191
- this.hic.state[this.hic.state.currView].matrixType = "observed";
2192
- }
2193
- if (!this.hic.state[this.hic.state.currView]?.nmeth) {
2194
- this.hic.state[this.hic.state.currView].nmeth = nmeth;
2195
- }
2196
- }
2197
- for (const v of this.views) {
2198
- if (!this.hic.state[v]) {
2199
- this.hic.state[v] = {
2200
- matrixType: "observed",
2201
- nmeth
2202
- };
2203
- }
2204
- }
2205
- }
2206
- async init() {
2207
- this.determineView();
2208
- try {
2209
- await hicParseFile(this.hic, true, this.errList);
2210
- this.getViewsConfig();
2211
- this.store = await hicStoreInit({ app: this.api, state: this.hic.state });
2212
- this.state = await this.store.copyState();
2213
- this.components = {
2214
- loadingOverlay: await loadingInit({
2215
- app: this.api,
2216
- loadingDiv: this.dom.loadingDiv
2217
- }),
2218
- view: await viewCompInit({
2219
- app: this.api,
2220
- state: this.state,
2221
- dom: this.dom,
2222
- hic: this.hic,
2223
- errList: this.errList,
2224
- error: this.error
2225
- })
2226
- };
2227
- await this.api.dispatch();
2228
- } catch (e) {
2229
- console.error(e.stack || e);
2230
- }
2231
- }
2232
- main() {
2233
- if (this.errList.length) {
2234
- this.error(this.errList);
2235
- this.dom.loadingDiv.style("display", "none");
2236
- return;
2237
- }
2238
- }
2239
- };
2240
- var hicInit = getAppInit(HicApp);
2241
- export {
2242
- hicInit
2243
- };
2244
- //# sourceMappingURL=HicApp-ZCMOOKTY.js.map