@sjcrh/proteinpaint-client 2.196.0 → 2.198.0

package/dist/chunk-CDJAHMAN.js

@@ -1,299 +0,0 @@
-import {
-  first_genetrack_tolist,
-  gmmode,
-  sayerror
-} from "./chunk-WY2PGUVX.js";
-import {
-  dofetch3
-} from "./chunk-LYVLF6HO.js";
-import {
-  codon_stop,
-  nt2aa,
-  proteinDomainColorScale
-} from "./chunk-7KRS7L4U.js";
-import {
-  select_default
-} from "./chunk-I6Y4O3RR.js";
-
-// common/snp.js
-async function string2snp(genome, str) {
-  const data = await dofetch3("snp", {
-    method: "POST",
-    body: JSON.stringify({ byName: true, genome: genome.name, lst: [str] })
-  });
-  if (data.error) throw data.error;
-  if (!data.results || data.results.length == 0) throw str + ": not a SNP";
-  for (const i of data.results) {
-    const chr = genome.chrlookup[i.chrom.toUpperCase()];
-    if (chr && chr.major) {
-      return {
-        chr: i.chrom,
-        start: i.chromStart,
-        stop: i.chromEnd
-      };
-    }
-  }
-  const r = data.results[0];
-  return {
-    chr: r.chrom,
-    start: r.chromStart,
-    stop: r.chromEnd
-  };
-}
-
-// src/block.init.js
-async function block_init_default(arg) {
-  if (!arg.holder) throw "No holder for block.init";
-  if (!arg.genome) throw "no genome";
-  if (arg.holder instanceof Element) arg.holder = select_default(arg.holder);
-  if (!arg.tklst) arg.tklst = [];
-  if (arg.query) {
-    await step1_findgm(arg);
-    return;
-  }
-  if (arg.model && arg.allmodels) {
-    await step2_getseq(arg);
-    return;
-  }
-}
-async function step1_findgm(arg) {
-  const wait = arg.holder.append("p").style("font-size", "2em").style("color", "#858585").text("Searching for " + arg.query + " ...");
-  const data = await dofetch3("genelookup", {
-    body: { deep: 1, input: arg.query, genome: arg.genome.name }
-  });
-  if (!data) throw "querying genes: server error";
-  if (data.error) throw "error querying genes: " + data.error;
-  if (!data.gmlst || data.gmlst.length == 0) {
-    if (arg.genome.hasSNP) {
-      try {
-        const r = await string2snp(arg.genome, arg.query);
-        wait.remove();
-        const par = {
-          genome: arg.genome,
-          holder: arg.holder,
-          chr: r.chr,
-          start: Math.max(0, r.start - 300),
-          stop: r.start + 300,
-          nobox: true,
-          tklst: arg.tklst,
-          debugmode: arg.debugmode
-        };
-        first_genetrack_tolist(arg.genome, par.tklst);
-        const b = await import("./block-YPM767A4.js");
-        const block = new b.Block(par);
-        block.addhlregion(r.chr, r.start, r.stop - 1);
-      } catch (e) {
-        wait.text("Not a gene or SNP: " + arg.query);
-      }
-    } else {
-      wait.text("No match to gene: " + arg.query);
-    }
-    return;
-  }
-  wait.remove();
-  arg.allmodels = data.gmlst;
-  for (const m of arg.allmodels) {
-    if (m.isoform.toUpperCase() == (data.found_isoform ? data.found_isoform.toUpperCase() : arg.query.toUpperCase())) {
-      arg.model = m;
-      await step2_getseq(arg);
-      return;
-    }
-  }
-  const defaultisoforms = [];
-  for (const m of arg.allmodels) {
-    if (!m.isoform) throw "isoform missing from one gene model: " + JSON.stringify(m);
-    const n = m.isoform.toUpperCase();
-    if (arg.genome.isoformcache.has(n)) {
-      let nothas = true;
-      for (const m2 of arg.genome.isoformcache.get(n)) {
-        if (m2.chr == m.chr && m2.start == m.start && m2.stop == m.stop && m2.strand == m.strand) {
-          nothas = false;
-          break;
-        }
-      }
-      if (nothas) {
-        arg.genome.isoformcache.get(n).push(m);
-      }
-    } else {
-      arg.genome.isoformcache.set(n, [m]);
-    }
-    if (m.isoform.toUpperCase() == arg.query.toUpperCase()) {
-      defaultisoforms.push(m);
-      break;
-    }
-    if (m.isdefault) {
-      defaultisoforms.push(m);
-    }
-  }
-  if (defaultisoforms.length == 1) {
-    arg.model = defaultisoforms[0];
-  } else if (defaultisoforms.length > 1) {
-    for (const m of defaultisoforms) {
-      if (m.chr == "chrY") {
-        continue;
-      }
-      const chr = arg.genome.chrlookup[m.chr.toUpperCase()];
-      if (!chr) {
-        continue;
-      }
-      if (!chr.major) {
-        continue;
-      }
-      arg.model = m;
-      break;
-    }
-    if (!arg.model) {
-      arg.model = defaultisoforms[0];
-    }
-  }
-  if (!arg.model) {
-    arg.model = arg.allmodels[0];
-  }
-  await step2_getseq(arg);
-}
-async function step2_getseq(arg) {
-  if (arg.model.genomicseq) {
-    checker();
-    step2_getpdomain(arg);
-    return;
-  }
-  const par = {
-    genome: arg.genome.name,
-    coord: arg.model.chr + ":" + (arg.model.start + 1) + "-" + arg.model.stop
-  };
-  const data = await dofetch3("ntseq", { method: "POST", body: JSON.stringify(par) });
-  if (!data) throw "getting sequence: server error";
-  if (data.error) throw "getting sequence: " + data.error;
-  if (!data.seq) throw "no nt seq???";
-  arg.model.genomicseq = data.seq.toUpperCase();
-  arg.model.aaseq = nt2aa(arg.model);
-  checker();
-  await step2_getpdomain(arg);
-  function checker() {
-    if (arg.model.aaseq) {
-      const stop = arg.model.aaseq.indexOf(codon_stop);
-      const cdslen = arg.model.cdslen - (arg.model.startCodonFrame ? 3 - arg.model.startCodonFrame : 0);
-      if (stop != -1 && stop < cdslen / 3 - 1) {
-        sayerror(arg.holder, "Translating " + arg.model.isoform + " ends at " + stop + " AA, expecting " + cdslen / 3);
-      }
-    }
-  }
-}
-async function step2_getpdomain(arg) {
-  const isoform2gm = /* @__PURE__ */ new Map();
-  for (const m of arg.allmodels) {
-    if (!m.pdomains) {
-      m.pdomains = [];
-      m.domain_hidden = {};
-      if (!isoform2gm.has(m.isoform)) isoform2gm.set(m.isoform, []);
-      isoform2gm.get(m.isoform).push(m);
-    }
-  }
-  if (isoform2gm.size == 0) {
-    await step3(arg);
-    return;
-  }
-  const data = await dofetch3("pdomain", {
-    method: "POST",
-    body: JSON.stringify({ genome: arg.genome.name, isoforms: [...isoform2gm.keys()] })
-  });
-  if (data.error) throw "error getting protein domain: " + data.error;
-  if (!Array.isArray(data.lst)) throw ".lst[] not array";
-  for (const a of data.lst) {
-    for (const m of isoform2gm.get(a.name)) {
-      m.pdomains = a.pdomains;
-      if (arg.hidePdomain) {
-        for (const i of a.pdomains) {
-          m.domain_hidden[i.name + i.description] = 1;
-        }
-      }
-    }
-  }
-  if (arg.geneDomains) {
-    if (typeof arg.geneDomains != "object") throw "geneDomains not object";
-    for (const isoform in arg.geneDomains) {
-      const lst = isoform2gm.get(isoform);
-      if (!lst) throw `unknown isoform ${isoform} from geneDomains{}`;
-      for (const g of lst) {
-        if (!g.pdomains) g.pdomains = [];
-        if (!Array.isArray(arg.geneDomains[isoform])) throw `geneDomains[${isoform}] not array`;
-        for (const b of arg.geneDomains[isoform]) {
-          if (typeof b != "object") throw "element from geneDomains[] not object";
-          if (!Number.isInteger(b.start)) throw "start not integer from geneDomains[]";
-          if (!Number.isInteger(b.stop)) throw "stop not integer from geneDomains[]";
-          if (b.start > b.stop) throw "start>stop from geneDomains[]";
-          if (!b.name) b.name = "Custom domain";
-          if (!g.pdomains.find((a) => a.start == b.start && a.stop == b.stop && a.name == b.name)) g.pdomains.push(b);
-        }
-      }
-    }
-  }
-  const s = proteinDomainColorScale();
-  for (const lst of isoform2gm.values()) {
-    for (const g of lst) {
-      for (const d of g.pdomains || []) {
-        if (!d.color) d.color = s(d.name + d.description);
-      }
-    }
-  }
-  await step3(arg);
-}
-async function step3(arg) {
-  let mode = arg.gmmode;
-  if (!mode) {
-    if (arg.model.cdslen) {
-      mode = gmmode.protein;
-    } else {
-      mode = gmmode.exononly;
-    }
-  }
-  if (arg.dataset) {
-    if (!Array.isArray(arg.dataset)) throw "dataset is not array";
-    for (const dsname of arg.dataset) {
-      if (arg.genome.datasets[dsname] && !arg.genome.datasets[dsname].legacyDsIsUninitiated) continue;
-      const d = await dofetch3(`getDataset?genome=${arg.genome.name}&dsname=${dsname}`);
-      if (d.error) throw `invalid name from dataset[]: ${d.error}`;
-      if (!d.ds) throw ".ds missing";
-      const ds = arg.genome.datasets[d.ds.label];
-      Object.assign(ds, d.ds);
-      const _ = await import("./legacyDataset-TNIIJABK.js");
-      _.validate_oldds(ds);
-      delete ds.legacyDsIsUninitiated;
-    }
-  }
-  const b = await import("./block-YPM767A4.js");
-  arg.__blockInstance = new b.Block({
-    genome: arg.genome,
-    holder: arg.holder,
-    nobox: true,
-    usegm: arg.model,
-    gmstackheight: 37,
-    allgm: arg.allmodels,
-    datasetlst: arg.dataset,
-    legacyDsFilter: arg.legacyDsFilter,
-    mset: arg.mset,
-    hlaachange: arg.hlaachange,
-    hlvariants: arg.hlvariants,
-    hlregions: arg.hlregions,
-    aarange: arg.aarange,
-    gmmode: mode,
-    hidedatasetexpression: arg.hidedatasetexpression,
-    hidegenecontrol: arg.hidegenecontrol,
-    hidegenelegend: arg.hidegenelegend,
-    variantPageCall_snv: arg.variantPageCall_snv,
-    datasetqueries: arg.datasetqueries,
-    samplecart: arg.samplecart,
-    debugmode: arg.debugmode,
-    tklst: arg.tklst,
-    mclassOverride: arg.mclassOverride,
-    hide_dsHandles: arg.hide_dsHandles,
-    onloadalltk_always: arg.onloadalltk_always,
-    onAddRemoveTk: arg.onAddRemoveTk
-  });
-}
-
-export {
-  string2snp,
-  block_init_default
-};
-//# sourceMappingURL=chunk-CDJAHMAN.js.map

package/dist/chunk-CXHLROWX.js

@@ -1,37 +0,0 @@
-import {
-  addGeneSearchbox,
-  getGEunit
-} from "./chunk-WY2PGUVX.js";
-import {
-  Menu
-} from "./chunk-HYOEWQ5P.js";
-import {
-  TermTypes
-} from "./chunk-NNFAUP2I.js";
-
-// termdb/handlers/geneExpression.ts
-var SearchHandler = class {
-  init(opts) {
-    this.callback = opts.callback;
-    this.app = opts.app;
-    const holder = opts.holder.append("div").style("padding", "10px 0px");
-    const geneSearch = addGeneSearchbox({
-      tip: new Menu({ padding: "0px" }),
-      genome: opts.genomeObj,
-      row: holder,
-      searchOnly: "gene",
-      callback: () => this.selectGene(geneSearch.geneSymbol)
-    });
-  }
-  async selectGene(gene) {
-    const unit = getGEunit(this.app.vocabApi);
-    const name = `${gene} ${unit}`;
-    if (!gene) throw new Error("No gene selected");
-    this.callback({ gene, name, type: TermTypes.GENE_EXPRESSION });
-  }
-};
-
-export {
-  SearchHandler
-};
-//# sourceMappingURL=chunk-CXHLROWX.js.map

package/dist/chunk-EKKQMKQI.js

@@ -1,102 +0,0 @@
-import {
-  addGeneSearchbox,
-  first_genetrack_tolist,
-  getDNAMethUnit,
-  sayerror
-} from "./chunk-WY2PGUVX.js";
-import {
-  Menu
-} from "./chunk-HYOEWQ5P.js";
-import {
-  DNA_METHYLATION
-} from "./chunk-NNFAUP2I.js";
-
-// termdb/handlers/dnaMethylation.ts
-var SearchHandler = class {
-  init(opts) {
-    this.opts = opts;
-    this.callback = opts.callback;
-    this.app = opts.app;
-    const holder = opts.holder.append("div").style("margin", "10px 0px");
-    this.dom = {};
-    this.dom.errDiv = holder.append("div").style("margin", "5px 0px").style("display", "none");
-    this.dom.geneSearchDiv = holder.append("div");
-    this.dom.blockDiv = holder.append("div").style("display", "none").style("margin", "15px 4px");
-    const geneSearch = addGeneSearchbox({
-      tip: new Menu({ padding: "0px" }),
-      genome: opts.genomeObj,
-      row: this.dom.geneSearchDiv,
-      callback: async () => {
-        try {
-          this.dom.errDiv.style("display", "none");
-          await this.handleGeneSearch(geneSearch);
-        } catch (e) {
-          this.dom.errDiv.style("display", "block");
-          sayerror(this.dom.errDiv, "Error: " + (e.message || e));
-          if (e.stack) console.log(e.stack);
-        }
-      }
-    });
-  }
-  async handleGeneSearch(geneSearch) {
-    if (geneSearch.geneSymbol) {
-      const { chr, start, stop } = geneSearch;
-      if (!chr || !Number.isInteger(start) || !Number.isInteger(stop))
-        throw new Error("unable to retrieve gene coordinate");
-      this.dom.blockDiv.selectAll("*").remove();
-      this.dom.blockDiv.style("display", "block");
-      this.dom.blockDiv.append("div").style("opacity", 0.6).text("Navigate genome browser to desired region");
-      const arg = {
-        holder: this.dom.blockDiv,
-        genome: this.opts.genomeObj,
-        // genome obj
-        chr,
-        start,
-        stop,
-        tklst: [],
-        nobox: true,
-        width: 500,
-        hidegenelegend: true,
-        debugmode: this.opts.debug
-      };
-      first_genetrack_tolist(this.opts.genomeObj, arg.tklst);
-      const _ = await import("./block-YPM767A4.js");
-      this.blockInstance = new _.Block(arg);
-      this.dom.submitBtn = this.dom.blockDiv.append("div").attr("data-testid", "sjpp-dnaMethylation-submitDiv").style("margin", "10px 0px").append("button").style("border", "none").style("border-radius", "20px").style("padding", "10px 15px").text("Submit Region").on("click", async () => {
-        const { chr: chr2, start: start2, stop: stop2 } = this.blockInstance.rglst[0];
-        const term = this.makeTerm({ chr: chr2, start: start2, stop: stop2 });
-        await this.callback(term);
-      });
-    } else if (geneSearch.chr && Number.isInteger(geneSearch.start) && Number.isInteger(geneSearch.stop)) {
-      const { chr } = geneSearch;
-      let { start, stop } = geneSearch;
-      if (geneSearch.actualposition?.len <= 1) {
-        start = geneSearch.actualposition.position;
-        stop = start + 1;
-      }
-      const term = this.makeTerm({ chr, start, stop });
-      await this.callback(term);
-    } else {
-      throw new Error("invalid gene search input");
-    }
-  }
-  makeTerm(opts) {
-    const { chr, start, stop } = opts;
-    if (!chr || !Number.isInteger(start) || !Number.isInteger(stop)) throw new Error("invalid coordinate");
-    const unit = getDNAMethUnit("region", this.app.vocabApi);
-    const term = {
-      chr,
-      start,
-      stop,
-      type: DNA_METHYLATION,
-      unit,
-      genomicFeatureType: "region"
-    };
-    return term;
-  }
-};
-
-export {
-  SearchHandler
-};
-//# sourceMappingURL=chunk-EKKQMKQI.js.map

package/dist/chunk-EPWIJEMK.js

@@ -1,158 +0,0 @@
-import {
-  NumericDensity
-} from "./chunk-MNIBZTQE.js";
-import {
-  HandlerBase
-} from "./chunk-LSEFWW72.js";
-import {
-  Tabs
-} from "./chunk-HBW42TDT.js";
-
-// termsetting/handlers/NumericHandler.ts
-var NumericHandler = class extends HandlerBase {
-  constructor(opts) {
-    super(opts);
-    this.tabs = [];
-    this.handlerByMode = {};
-    this.dom = {};
-    this.opts = opts;
-    this.termsetting = opts.termsetting;
-    this.tw = opts.termsetting.tw;
-    this.tabs = this.setTabData();
-    this.density = new NumericDensity(opts);
-  }
-  getPillStatus() {
-    this.tw = this.termsetting.tw;
-    return this.tw.getStatus(this.termsetting.usecase, this.termsetting.data);
-  }
-  setTabData() {
-    const self = this.termsetting;
-    const tabs = [];
-    const callback = async (event, tabData) => {
-      if (event) event.stopPropagation();
-      try {
-        await this.setEditHandler(tabData);
-        await this.editHandler.showEditMenu(tabData.contentHolder);
-      } catch (e) {
-        this.dom.errdiv.style("display", "").text(e);
-      }
-    };
-    const numTabs = self.opts.numericEditMenuVersion.length;
-    if (self.opts.numericEditMenuVersion.includes("continuous")) {
-      tabs.push({
-        mode: "continuous",
-        label: self.term.type == "survival" ? "Time to Event" : "Continuous",
-        callback,
-        active: this.tw.q.mode === "continuous" || numTabs === 1
-      });
-    }
-    if (self.opts.numericEditMenuVersion.includes("discrete")) {
-      tabs.push({
-        mode: "discrete",
-        label: self.term.type == "survival" ? "Exit code" : "Discrete",
-        callback,
-        active: this.tw.q.mode === "discrete" || numTabs === 1
-      });
-    }
-    if (self.opts.numericEditMenuVersion.includes("spline")) {
-      tabs.push({
-        mode: "spline",
-        label: "Cubic spline",
-        callback,
-        active: this.tw.q.mode === "spline" || numTabs === 1
-      });
-    }
-    if (self.opts.numericEditMenuVersion.includes("binary")) {
-      tabs.push({
-        mode: "binary",
-        label: "Binary",
-        callback,
-        active: this.tw.q.mode === "binary" || numTabs === 1
-      });
-    }
-    return tabs;
-  }
-  async setEditHandler(tabData) {
-    if (!this.handlerByMode[tabData.mode]) {
-      switch (tabData.mode) {
-        case "continuous": {
-          const { NumContEditor } = await import("./NumContEditor-MIC7M73G.js");
-          this.handlerByMode.continuous = new NumContEditor(this.opts, this);
-          break;
-        }
-        case "discrete": {
-          const { NumDiscreteEditor } = await import("./NumDiscreteEditor-PRSUMS3I.js");
-          this.handlerByMode.discrete = new NumDiscreteEditor(this.opts, this);
-          break;
-        }
-        case "binary": {
-          const { NumBinaryEditor } = await import("./NumBinaryEditor-RL44SO3T.js");
-          this.handlerByMode.binary = new NumBinaryEditor(this.opts, this);
-          break;
-        }
-        case "spline": {
-          const { NumSplineEditor } = await import("./NumSplineEditor-XI7AT5LM.js");
-          this.handlerByMode.spline = new NumSplineEditor(this.opts, this);
-          break;
-        }
-        default:
-          throw `unexpected numeric tabData.mode='${tabData.mode}'`;
-          break;
-      }
-    }
-    this.editHandler = this.handlerByMode[tabData.mode];
-  }
-  async showEditMenu(div) {
-    try {
-      this.showLoading(div);
-      this.dom.errdiv = div.append("div").attr("class", "sja_errorbar").style("display", "none");
-      this.tw = this.termsetting.tw;
-      const self = this.tw;
-      for (const t of this.tabs) {
-        t.active = this.tabs.length === 1 || self.q.mode == t.mode || t.mode == "continuous" && !self.q.mode;
-      }
-      this.density_data = await this.density.setData();
-      await this.setEditHandler(this.tabs.find((t) => t.active));
-      this.dom.editDiv = div.append("div").attr("data-testid", "sjpp-num-ts-edit-div");
-      this.dom.btnDiv = div.append("div");
-      this.renderButtons(this.dom.btnDiv);
-      if (this.tabs.length > 1) {
-        this.dom.topBar = this.dom.editDiv.append("div").style("padding", "10px");
-        this.dom.topBar.append("span").html("Use as ");
-        new Tabs({
-          holder: this.dom.topBar.append("div").style("display", "inline-block"),
-          contentHolder: this.dom.editDiv.append("div"),
-          noTopContentStyle: true,
-          tabs: this.tabs
-        }).main();
-      } else {
-        await this.editHandler.showEditMenu(this.dom.editDiv);
-      }
-      this.dom.loadingDiv.style("display", "none");
-    } catch (e) {
-      this.hideLoading();
-      this.dom.errdiv.style("display", "").text(typeof e == "object" ? e.message || e.error || e : e);
-    }
-  }
-  renderButtons(btnDiv) {
-    btnDiv.append("button").style("margin", "5px").attr("data-testId", "sjpp_numeric_edit_apply").html("Apply").on("click", () => {
-      this.termsetting.q = this.editHandler.getEditedQ();
-      this.termsetting.dom.tip.hide();
-      this.termsetting.api.runCallback();
-    });
-    btnDiv.append("button").style("margin", "5px").attr("data-testId", "sjpp_numeric_edit_reset").html("Reset").on("click", () => {
-      this.editHandler.undoEdits();
-    });
-  }
-  destroy() {
-    for (const s of Object.values(this.dom)) {
-      if (typeof s.remove == "function") s.remove();
-    }
-    this.density.destroy();
-  }
-};
-
-export {
-  NumericHandler
-};
-//# sourceMappingURL=chunk-EPWIJEMK.js.map