@sjcrh/proteinpaint-client 2.185.0 → 2.186.0

package/dist/proteinView-AS6ZV2JT.js

@@ -1,758 +0,0 @@
-import {
-  LegendCircleReference,
-  PlotBase,
-  addGeneSearchbox,
-  axisstyle,
-  shapeSelector,
-  shapesArray,
-  table2col,
-  to_svg
-} from "./chunk-YWUVCXFS.js";
-import {
-  aa2gmcoord
-} from "./chunk-HJ6L54YS.js";
-import "./chunk-3QBZ2Y77.js";
-import {
-  Menu
-} from "./chunk-HYOEWQ5P.js";
-import "./chunk-FN5XPUPH.js";
-import "./chunk-G6O3URDN.js";
-import "./chunk-LSEFWW72.js";
-import {
-  icons
-} from "./chunk-KWM6B3NL.js";
-import "./chunk-UCLS2SVB.js";
-import {
-  dofetch3
-} from "./chunk-6ZCHECOT.js";
-import {
-  copyMerge,
-  getCompInit
-} from "./chunk-MVTCBVSX.js";
-import "./chunk-2K5DSRBJ.js";
-import "./chunk-X4NI4JLQ.js";
-import {
-  roundValue
-} from "./chunk-L4QG7XZE.js";
-import "./chunk-DQC5FFGV.js";
-import "./chunk-UWYCEYML.js";
-import "./chunk-7UHUOC6F.js";
-import "./chunk-ZYY54HBU.js";
-import {
-  NumericModes,
-  TermTypes
-} from "./chunk-EGWVYY7K.js";
-import {
-  getColors,
-  mclass
-} from "./chunk-AMYSEKPF.js";
-import "./chunk-TV74I3Y5.js";
-import "./chunk-KSGA62R2.js";
-import {
-  axisBottom,
-  axisLeft
-} from "./chunk-LOZEKOES.js";
-import "./chunk-TOU7EVFQ.js";
-import {
-  linear
-} from "./chunk-OAWQ6LOO.js";
-import "./chunk-KYBIQBXE.js";
-import {
-  creator_default,
-  select_default
-} from "./chunk-I6Y4O3RR.js";
-import {
-  rgb
-} from "./chunk-OMR2DT66.js";
-import "./chunk-HFNDKYVF.js";
-
-// plots/proteinView.ts
-var defaultConfig = {
-  chartType: "proteinView"
-};
-var ProteinView = class _ProteinView extends PlotBase {
-  static {
-    this.type = "proteinView";
-  }
-  constructor(opts, api) {
-    super(opts, api);
-    this.type = _ProteinView.type;
-    this.components = {};
-  }
-  async init() {
-    const holder = this.opts.holder.append("div").style("padding", "10px");
-    this.dom = {
-      holder,
-      body: holder.append("div"),
-      tip: new Menu({ padding: "" }),
-      header: this.opts.header
-    };
-    if (this.dom.header) this.dom.header.html("Protein View");
-  }
-  getState(appState) {
-    const config = appState.plots.find((p) => p.id === this.id);
-    if (!config) throw `No plot with id='${this.id}' found`;
-    return { config };
-  }
-  maySetSandboxHeader() {
-    if (!this.dom.header) return;
-    const term = this.state.config?.tw?.term;
-    const header = `Protein View: ${term?.name}`;
-    this.dom.header.text(header);
-  }
-  async main() {
-    const term = this.state.config?.tw?.term;
-    if (!term?.name) throw new Error("proteinView: selected protein term is missing");
-    const body = {
-      genome: this.app.opts.state.vocab.genome,
-      dslabel: this.app.opts.state.vocab.dslabel,
-      term: this.state.config.tw,
-      filter: this.state.config.filter,
-      filter0: this.state.config.filter0
-    };
-    this.maySetSandboxHeader();
-    const data = await dofetch3("termdb/proteome", { body });
-    if (data.error) throw data.error;
-    this.dom.body.selectAll("*").remove();
-    renderCohortVolcano(this.dom.body, data, this);
-    const ptmDataByIsoform = /* @__PURE__ */ new Map();
-    for (const cohortData of data.cohorts || []) {
-      if (!cohortData.PTMType) continue;
-      const isoform = cohortData.isoform;
-      const existingCohorts = ptmDataByIsoform.get(isoform);
-      if (!existingCohorts) {
-        ptmDataByIsoform.set(isoform, [cohortData]);
-      } else {
-        existingCohorts.push(cohortData);
-      }
-    }
-    for (const [isoform, ptmCohorts] of ptmDataByIsoform) {
-      await renderPTMLollipop(this.dom.body, ptmCohorts, this, isoform);
-    }
-  }
-};
-function renderCohortVolcano(holder, data, self) {
-  const dots = [];
-  for (const cohortData of data?.cohorts || []) {
-    const log2fc = getLog2Ratio(cohortData.foldChange);
-    const pValue = Number(cohortData.pValue);
-    const testedN = Number(cohortData.testedN);
-    const controlN = Number(cohortData.controlN);
-    if (log2fc === null || !Number.isFinite(pValue) || pValue <= 0) continue;
-    dots.push({
-      assayName: cohortData.assayName,
-      cohortName: cohortData.cohortName,
-      PTMType: cohortData.PTMType,
-      modSites: cohortData.modSites,
-      proteinAccession: cohortData.proteinAccession,
-      uniqueIdentifier: cohortData.uniqueIdentifier,
-      log2fc,
-      pValue,
-      score: -Math.log10(Math.max(pValue, 1e-300)),
-      testedN: Number.isFinite(testedN) ? testedN : 0,
-      controlN: Number.isFinite(controlN) ? controlN : 0
-    });
-  }
-  const panel = holder.append("div").style("margin-bottom", "14px");
-  const header = panel.append("div").style("display", "flex").style("align-items", "center").style("gap", "6px").style("margin-bottom", "6px");
-  const downloadBtn = header.append("div").style("display", "inline-block");
-  header.append("div").style("font-weight", 600).text("Cohort Volcano");
-  if (!dots.length) {
-    downloadBtn.style("display", "none");
-    panel.append("div").style("font-size", ".85em").style("color", "#666").text("No cohorts with valid fold-change and p-value to plot.");
-    return;
-  }
-  const width = 640;
-  const height = 660;
-  const margin = { top: 40, right: 70, bottom: 120, left: 70 };
-  const innerW = width - margin.left - margin.right;
-  const innerH = height - margin.top - margin.bottom;
-  let minX = Number.POSITIVE_INFINITY;
-  let maxX = Number.NEGATIVE_INFINITY;
-  let maxY = 0;
-  let maxTestedN = 0;
-  let minTestedN = Number.POSITIVE_INFINITY;
-  for (const p of dots) {
-    minX = Math.min(minX, p.log2fc);
-    maxX = Math.max(maxX, p.log2fc);
-    maxY = Math.max(maxY, p.score);
-    maxTestedN = Math.max(maxTestedN, p.testedN);
-    if (p.testedN > 0) minTestedN = Math.min(minTestedN, p.testedN);
-  }
-  if (maxY < 1) maxY = 1;
-  if (!Number.isFinite(minTestedN)) minTestedN = 1;
-  const xSpan = Math.max(0.05, maxX - minX);
-  const xPad = Math.max(0.01, xSpan * 0.1);
-  const xMin = Math.min(0, minX - xPad);
-  const xMax = Math.max(0, maxX + xPad);
-  const yMax = maxY * 1.15;
-  const xScale = linear().domain([xMin, xMax]).range([0, innerW]);
-  const yScale = linear().domain([0, yMax]).range([innerH, 0]);
-  const radiusRange = [4, 12];
-  const radiusScale = linear().domain([minTestedN, Math.max(minTestedN + 1, maxTestedN)]).range(radiusRange);
-  const assayNames = [...new Set(dots.map((d) => d.assayName))].sort();
-  const cohortNames = [...new Set(dots.map((d) => d.cohortName))].sort();
-  const proteinAccessions = [...new Set(dots.map((d) => d.proteinAccession))].sort();
-  const assayColorScale = getColors(assayNames.length).domain(assayNames);
-  const cohortColorScale = getColors(cohortNames.length).domain(cohortNames);
-  const proteinColorScale = getColors(proteinAccessions.length).domain(proteinAccessions);
-  const assayColors = new Map(assayNames.map((name) => [name, rgb(assayColorScale(name)).formatHex()]));
-  const cohortColors = new Map(cohortNames.map((name) => [name, rgb(cohortColorScale(name)).formatHex()]));
-  const proteinColors = new Map(
-    proteinAccessions.map((acc) => [acc, rgb(proteinColorScale(acc)).formatHex()])
-  );
-  const makeShapeMap = (items) => new Map(items.map((item, i) => [item, i % shapesArray.length]));
-  const assayShapes = makeShapeMap(assayNames);
-  const cohortShapes = makeShapeMap(cohortNames);
-  const proteinShapes = makeShapeMap(proteinAccessions);
-  let colorMode = "assayType";
-  let shapeMode = "none";
-  const defaultDotColor = "#9ca3af";
-  const getColor = (d) => {
-    switch (colorMode) {
-      case "none":
-        return defaultDotColor;
-      case "assayType":
-        return assayColors.get(d.assayName) ?? "#888";
-      case "cohort":
-        return cohortColors.get(d.cohortName) ?? "#888";
-      case "proteinAccession":
-        return proteinColors.get(d.proteinAccession) ?? "#888";
-      default:
-        return "#888";
-    }
-  };
-  const getShapeIndex = (d) => {
-    switch (shapeMode) {
-      case "none":
-        return 0;
-      case "assayType":
-        return assayShapes.get(d.assayName) ?? 0;
-      case "cohort":
-        return cohortShapes.get(d.cohortName) ?? 0;
-      case "proteinAccession":
-        return proteinShapes.get(d.proteinAccession) ?? 0;
-      default:
-        return 0;
-    }
-  };
-  const getShapePath = (d) => {
-    const index = getShapeIndex(d) % shapesArray.length;
-    return shapesArray[index];
-  };
-  const getShapeTransform = (d, sizeScale = 1) => {
-    const r = radiusScale(Math.max(minTestedN, d.testedN || minTestedN)) * sizeScale;
-    const scale = r / 8;
-    const x = xScale(d.log2fc) - 8 * scale;
-    const y = yScale(d.score) - 8 * scale;
-    return `translate(${x},${y}) scale(${scale})`;
-  };
-  const groupingModes = [
-    { key: "none", label: "Default" },
-    { key: "assayType", label: "Assay" },
-    { key: "cohort", label: "Cohort" },
-    { key: "proteinAccession", label: "Isoform" }
-  ];
-  const makeHiddenState = () => ({
-    none: /* @__PURE__ */ new Set(),
-    assayType: /* @__PURE__ */ new Set(),
-    cohort: /* @__PURE__ */ new Set(),
-    proteinAccession: /* @__PURE__ */ new Set()
-  });
-  const hiddenColor = makeHiddenState();
-  const hiddenShape = makeHiddenState();
-  const getValueByMode = (d, mode) => {
-    switch (mode) {
-      case "none":
-        return "";
-      case "assayType":
-        return d.assayName;
-      case "cohort":
-        return d.cohortName;
-      case "proteinAccession":
-        return d.proteinAccession;
-      default:
-        return "";
-    }
-  };
-  const isDotHidden = (d) => {
-    const colorValue = getValueByMode(d, colorMode);
-    const shapeValue = getValueByMode(d, shapeMode);
-    return hiddenColor[colorMode].has(colorValue) || hiddenShape[shapeMode].has(shapeValue);
-  };
-  const getDotDistancePx = (d1, d2) => {
-    const x = xScale(d1.log2fc) - xScale(d2.log2fc);
-    const y = yScale(d1.score) - yScale(d2.score);
-    return Math.sqrt(x * x + y * y);
-  };
-  const getVisibleDots = () => dots.filter((d) => !isDotHidden(d));
-  const getVisibleTestedNStats = () => {
-    const visibleDots = getVisibleDots();
-    if (!visibleDots.length) {
-      return { domainMin: 1, domainMax: 2, minLabel: 0, maxLabel: 0 };
-    }
-    let visibleMax = 0;
-    let visibleMin = Number.POSITIVE_INFINITY;
-    for (const d of visibleDots) {
-      visibleMax = Math.max(visibleMax, d.testedN);
-      if (d.testedN > 0) visibleMin = Math.min(visibleMin, d.testedN);
-    }
-    if (!Number.isFinite(visibleMin)) visibleMin = 1;
-    const domainMax = Math.max(visibleMin + 1, visibleMax);
-    return { domainMin: visibleMin, domainMax, minLabel: visibleMin, maxLabel: visibleMax || visibleMin };
-  };
-  const updateRadiusScaleForVisibleDots = () => {
-    const stats = getVisibleTestedNStats();
-    radiusScale.domain([stats.domainMin, stats.domainMax]).range(radiusRange);
-    return stats;
-  };
-  const getClusterDots = (seed) => {
-    const thresholdPx = 5;
-    return dots.filter((d) => !isDotHidden(d) && getDotDistancePx(d, seed) < thresholdPx).sort((a, b) => getDotDistancePx(a, seed) - getDotDistancePx(b, seed));
-  };
-  const renderClusterTooltip = (clusterDots) => {
-    const tip = self.dom.tip.clear().d;
-    if (clusterDots.length > 1) {
-      tip.append("div").style("color", "#888").style("font-weight", "bold").style("margin", "0 0 6px 0").text(`${clusterDots.length} Cohorts`);
-    }
-    const list = tip.append("div");
-    if (clusterDots.length > 1) {
-      const grouped = /* @__PURE__ */ new Map();
-      for (const d of clusterDots) {
-        const key = [d.assayName, d.cohortName, d.modSites || ""].join("	");
-        if (!grouped.has(key)) grouped.set(key, d);
-      }
-      for (const d of grouped.values()) {
-        const block = list.append("div").style("padding", "3px 0").style("border-bottom", "1px solid #f1f1f1");
-        const table = table2col({ holder: block.append("table") });
-        table.addRow("Assay", d.assayName);
-        table.addRow("Cohort", d.cohortName);
-        if (d.modSites) table.addRow("Modified Site", d.modSites);
-      }
-      return;
-    }
-    for (const d of clusterDots) {
-      const block = list.append("div").style("padding", "3px 0").style("border-bottom", "1px solid #f1f1f1");
-      const table = table2col({ holder: block.append("table") });
-      table.addRow("Assay", d.assayName);
-      table.addRow("Cohort", d.cohortName);
-      table.addRow("Protein Accession", d.proteinAccession);
-      if (d.PTMType) {
-        table.addRow("PTM Type", d.PTMType);
-        table.addRow("Modified Site", d.modSites);
-        table.addRow("PTM", d.uniqueIdentifier);
-      } else {
-        table.addRow("Isoform", d.uniqueIdentifier);
-      }
-      table.addRow("log2 fold change", roundValue(d.log2fc, 3));
-      table.addRow("p value", d.pValue.toExponential(2));
-      table.addRow("-log10(p)", roundValue(d.score, 3));
-      table.addRow("Tested samples", d.testedN);
-      table.addRow("Control samples", d.controlN);
-    }
-  };
-  const updateDots = () => {
-    cohortDots.attr("fill", (d) => getColor(d)).attr("stroke", (d) => getColor(d)).attr("d", (d) => getShapePath(d)).attr("transform", (d) => getShapeTransform(d)).style("opacity", (d) => isDotHidden(d) ? 0 : 1).style("pointer-events", (d) => isDotHidden(d) ? "none" : "auto");
-  };
-  const getShapeMapInUse = () => {
-    switch (shapeMode) {
-      case "none":
-        return assayShapes;
-      case "assayType":
-        return assayShapes;
-      case "cohort":
-        return cohortShapes;
-      case "proteinAccession":
-        return proteinShapes;
-      default:
-        return assayShapes;
-    }
-  };
-  const plotAndLegend = panel.append("div").style("display", "flex").style("align-items", "flex-start").style("gap", "14px").style("flex-wrap", "wrap");
-  const svg = plotAndLegend.append("svg").attr("width", width).attr("height", height).style("display", "block").style("max-width", "100%").style("height", "auto");
-  const g = svg.append("g").attr("transform", `translate(${margin.left},${margin.top})`);
-  const xAxis = g.append("g").attr("transform", `translate(0,${innerH})`).call(axisBottom(xScale));
-  axisstyle({ axis: xAxis, color: "black", showline: true });
-  const yAxis = g.append("g").call(axisLeft(yScale));
-  axisstyle({ axis: yAxis, color: "black", showline: true });
-  const x0 = xScale(0);
-  const pThreshold = -Math.log10(0.05);
-  const thresholdY = yScale(Math.min(yMax, pThreshold));
-  g.append("line").attr("x1", x0).attr("x2", x0).attr("y1", 0).attr("y2", innerH).attr("stroke", "black").attr("stroke-dasharray", "5 4").attr("stroke-opacity", 0.4);
-  g.append("line").attr("x1", 0).attr("x2", innerW).attr("y1", thresholdY).attr("y2", thresholdY).attr("stroke", "black").attr("stroke-dasharray", "5 4").attr("stroke-opacity", 0.4);
-  g.append("text").attr("x", innerW / 2).attr("y", innerH + 44).attr("text-anchor", "middle").style("font-weight", 600).text("log2 fold change (disease / control)");
-  g.append("text").attr("transform", `translate(${-50},${innerH / 2}) rotate(-90)`).attr("text-anchor", "middle").style("font-weight", 600).text("-log10(p-value)");
-  const cohortDots = g.selectAll("path.cohort-dot").data(dots).enter().append("path").attr("class", "cohort-dot").attr("transform", (d) => getShapeTransform(d, 0.9)).attr("d", (d) => getShapePath(d)).attr("fill", (d) => getColor(d)).attr("fill-opacity", 0.5).attr("stroke", (d) => getColor(d)).attr("stroke-width", 1).style("cursor", "pointer");
-  cohortDots.transition().duration(350).attr("d", (d) => getShapePath(d)).attr("transform", (d) => getShapeTransform(d, 1));
-  updateDots();
-  cohortDots.on("mouseover", function(_event, d) {
-    const clusterDots = getClusterDots(d);
-    renderClusterTooltip(clusterDots);
-    self.dom.tip.showunder(this);
-  }).on("mouseout", () => {
-    self.dom.tip.hide();
-  }).on("click", (_event, d) => launchViolinPlot(self, d.assayName, d.cohortName, d.uniqueIdentifier));
-  const legend = plotAndLegend.append("div").style("margin", "0").style("min-width", "220px").style("font-size", ".75em").style("color", "#374151");
-  function renderSizeLegend() {
-    legendSvg.selectAll("*").remove();
-    const stats = updateRadiusScaleForVisibleDots();
-    new LegendCircleReference({
-      g: legendSvg.append("g").attr("transform", "translate(12, 8)"),
-      inputMax: radiusRange[1],
-      inputMin: radiusRange[0],
-      maxLabel: stats.maxLabel,
-      maxRadius: radiusScale(stats.domainMax),
-      minLabel: stats.minLabel,
-      minRadius: radiusScale(stats.domainMin),
-      title: "",
-      menu: {
-        minMaxLabel: "pixels",
-        callback: async (obj) => {
-          radiusRange[0] = obj.min;
-          radiusRange[1] = obj.max;
-          radiusScale.range([obj.min, obj.max]);
-          updateDots();
-          renderSizeLegend();
-        }
-      }
-    });
-  }
-  const refreshAfterVisibilityChange = () => {
-    updateRadiusScaleForVisibleDots();
-    updateDots();
-    renderColorLegend();
-    renderSizeLegend();
-  };
-  const termName = self.state.config?.tw?.term?.name || "";
-  const svgName = `${termName}.cohort-volcano`;
-  const downloadVolcanoSvg = () => {
-    const plotNode = svg.node();
-    const legendNode = legend.node();
-    if (!plotNode) return;
-    const plotWidth = width;
-    const plotHeight = height;
-    const legendRect = legendNode?.getBoundingClientRect();
-    const legendWidth = Math.max(220, Math.ceil(legendRect?.width || 220));
-    const legendHeight = Math.max(plotHeight, Math.ceil(legendRect?.height || 0));
-    const gap = 14;
-    const combinedSvg = select_default(creator_default("svg").call(document.documentElement)).attr("width", plotWidth + gap + legendWidth).attr("height", legendHeight);
-    combinedSvg.append(() => plotNode.cloneNode(true));
-    combinedSvg.append("foreignObject").attr("x", plotWidth + gap).attr("y", 0).attr("width", legendWidth).attr("height", legendHeight).append(() => {
-      const clone = legendNode.cloneNode(true);
-      clone.style.margin = "0px";
-      clone.style.minWidth = "0px";
-      return clone;
-    });
-    to_svg(combinedSvg.node(), svgName, { apply_dom_styles: true });
-  };
-  icons.download(downloadBtn, { handler: downloadVolcanoSvg, title: "Download" });
-  const colorLegendDiv = legend.append("div").style("margin-bottom", "12px");
-  const shapeLegendDiv = legend.append("div").style("margin-bottom", "12px");
-  const sizeLegendRow = legend.append("div").style("display", "flex").style("align-items", "flex-start").style("gap", "8px").style("margin-top", "8px");
-  sizeLegendRow.append("span").style("display", "inline-block").style("margin-top", "42px").text("Tested sample size");
-  const legendSvg = sizeLegendRow.append("svg").attr("width", 190).attr("height", 110).style("display", "block");
-  function renderColorLegend() {
-    colorLegendDiv.selectAll("*").remove();
-    shapeLegendDiv.selectAll("*").remove();
-    const modeRow = colorLegendDiv.append("div").style("display", "flex").style("gap", "10px").style("margin-bottom", "6px").style("flex-wrap", "wrap");
-    modeRow.append("span").text("Color by");
-    for (const { key, label } of groupingModes) {
-      modeRow.append("span").text(label).style("cursor", "pointer").style("font-weight", key === colorMode ? "600" : "400").style("text-decoration", key === colorMode ? "underline" : "none").style("color", key === colorMode ? "#111" : "#6b7280").on("click", () => {
-        colorMode = key;
-        refreshAfterVisibilityChange();
-      });
-    }
-    const makeLegendItems = (items, colorMap) => {
-      const openColorMenu = (event, name, swatch) => {
-        const menu = new Menu({ padding: "0px" });
-        const div = menu.d.append("div");
-        const hidden = hiddenColor[colorMode].has(name);
-        const hiddenCount = hiddenColor[colorMode].size;
-        div.append("div").attr("class", "sja_menuoption sja_sharp_border").text(hidden ? "Show" : "Hide").on("click", () => {
-          if (hidden) hiddenColor[colorMode].delete(name);
-          else hiddenColor[colorMode].add(name);
-          refreshAfterVisibilityChange();
-          menu.hide();
-        });
-        div.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Show only").on("click", () => {
-          hiddenColor[colorMode].clear();
-          for (const item of items) {
-            if (item != name) hiddenColor[colorMode].add(item);
-          }
-          refreshAfterVisibilityChange();
-          menu.hide();
-        });
-        if (hiddenCount > 1)
-          div.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Show all").on("click", () => {
-            hiddenColor[colorMode].clear();
-            refreshAfterVisibilityChange();
-            menu.hide();
-          });
-        const input = div.append("div").attr("class", "sja_sharp_border").style("padding", "0px 10px").text("Color:").append("input").attr("type", "color").attr("value", colorMap.get(name) ?? "#888").on("change", () => {
-          const newColor = input.node().value;
-          colorMap.set(name, newColor);
-          swatch.style("background", newColor);
-          updateDots();
-          menu.hide();
-        });
-        menu.showunder(event.target);
-      };
-      for (const name of items) {
-        const hidden = hiddenColor[colorMode].has(name);
-        const row = colorLegendDiv.append("div").style("display", "flex").style("align-items", "center").style("gap", "6px").style("margin-bottom", "3px");
-        const swatch = row.append("span").style("display", "inline-block").style("width", "10px").style("height", "10px").style("border-radius", "50%").style("background", colorMap.get(name) ?? "#888").style("opacity", hidden ? 0.35 : 0.8).style("flex-shrink", "0").style("cursor", "pointer");
-        swatch.on("click", (event) => openColorMenu(event, name, swatch));
-        row.append("span").text(name).style("text-decoration", hidden ? "line-through" : "none").style("cursor", "pointer").on("click", (event) => openColorMenu(event, name, swatch));
-      }
-    };
-    if (colorMode === "assayType") {
-      makeLegendItems(assayNames, assayColors);
-    } else if (colorMode === "cohort") {
-      makeLegendItems(cohortNames, cohortColors);
-    } else if (colorMode === "proteinAccession") {
-      makeLegendItems(proteinAccessions, proteinColors);
-    }
-    const shapeModeRow = shapeLegendDiv.append("div").style("display", "flex").style("gap", "10px").style("margin-bottom", "6px").style("flex-wrap", "wrap");
-    shapeModeRow.append("span").text("Shape by");
-    for (const { key, label } of groupingModes) {
-      shapeModeRow.append("span").text(label).style("cursor", "pointer").style("font-weight", key === shapeMode ? "600" : "400").style("text-decoration", key === shapeMode ? "underline" : "none").style("color", key === shapeMode ? "#111" : "#6b7280").on("click", () => {
-        shapeMode = key;
-        refreshAfterVisibilityChange();
-      });
-    }
-    const drawShapeLegend = (items, shapeMap) => {
-      const openShapeMenu = (event, name) => {
-        const menu = new Menu({ padding: "0px" });
-        const activeShapeMap = getShapeMapInUse();
-        const div = menu.d.append("div");
-        const hidden = hiddenShape[shapeMode].has(name);
-        const hiddenCount = hiddenShape[shapeMode].size;
-        div.append("div").attr("class", "sja_menuoption sja_sharp_border").text(hidden ? "Show" : "Hide").on("click", () => {
-          if (hidden) hiddenShape[shapeMode].delete(name);
-          else hiddenShape[shapeMode].add(name);
-          refreshAfterVisibilityChange();
-          menu.hide();
-        });
-        div.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Show only").on("click", () => {
-          hiddenShape[shapeMode].clear();
-          for (const item of items) {
-            if (item != name) hiddenShape[shapeMode].add(item);
-          }
-          refreshAfterVisibilityChange();
-          menu.hide();
-        });
-        if (hiddenCount > 1)
-          div.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Show all").on("click", () => {
-            hiddenShape[shapeMode].clear();
-            refreshAfterVisibilityChange();
-            menu.hide();
-          });
-        div.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Change shape").on("click", () => {
-          div.selectAll("*").remove();
-          shapeSelector(div, (index) => {
-            activeShapeMap.set(name, index);
-            updateDots();
-            renderColorLegend();
-            menu.hide();
-          });
-        });
-        menu.showunder(event.target);
-      };
-      for (const name of items) {
-        const hidden = hiddenShape[shapeMode].has(name);
-        const row = shapeLegendDiv.append("div").style("display", "flex").style("align-items", "center").style("gap", "6px").style("margin-bottom", "3px");
-        const icon = row.append("svg").attr("width", 16).attr("height", 16).style("display", "inline-block").style("cursor", "pointer");
-        icon.append("path").attr("transform", "scale(0.8)").attr("d", shapesArray[(shapeMap.get(name) || 0) % shapesArray.length]).attr("fill", "#4b5563").attr("fill-opacity", hidden ? 0.35 : 0.9);
-        icon.on("click", (event) => openShapeMenu(event, name));
-        row.append("span").text(name).style("text-decoration", hidden ? "line-through" : "none").style("cursor", "pointer").on("click", (event) => openShapeMenu(event, name));
-      }
-    };
-    if (shapeMode === "assayType") {
-      drawShapeLegend(assayNames, assayShapes);
-    } else if (shapeMode === "cohort") {
-      drawShapeLegend(cohortNames, cohortShapes);
-    } else if (shapeMode === "proteinAccession") {
-      drawShapeLegend(proteinAccessions, proteinShapes);
-    }
-  }
-  updateRadiusScaleForVisibleDots();
-  renderColorLegend();
-  renderSizeLegend();
-}
-function launchViolinPlot(self, assayName, cohortName, isoform) {
-  const selectedProtein = self.state.config?.tw?.term;
-  if (!selectedProtein) throw new Error("proteinView: selected protein term is missing");
-  const action = {
-    type: "plot_create",
-    config: {
-      chartType: "summary"
-    }
-  };
-  action.config.assayCohortTitle = `${assayName}: ${cohortName}`;
-  action.config.proteomeDetails = { assay: assayName, cohort: cohortName };
-  const termdbConfig = self.app.vocabApi.termdbConfig;
-  const proteomeOverlayTerm = termdbConfig?.queries?.proteome?.overlayTerm;
-  const t = structuredClone(selectedProtein);
-  t.name = `${t.name}: ${isoform}`;
-  t.proteomeDetails = { assay: assayName, cohort: cohortName };
-  action.config.term = { term: t, q: { mode: NumericModes.continuous } };
-  if (proteomeOverlayTerm) {
-    action.config.term2 = { term: structuredClone(proteomeOverlayTerm), q: {} };
-  }
-  self.app.dispatch(action);
-}
-async function renderPTMLollipop(holder, ptmCohorts, self, isoform) {
-  if (!ptmCohorts?.length) return;
-  const custom_variants = [];
-  const mergedMclassOverride = {};
-  const gm = await getGmForPTM(ptmCohorts[0].geneName, self.app.opts.genome.name, isoform);
-  for (const ptm of ptmCohorts) {
-    if (!gm) continue;
-    const logValue = getLog2Ratio(ptm.foldChange);
-    const pValue = Number(ptm.pValue);
-    const testedN = Number(ptm.testedN);
-    const controlN = Number(ptm.controlN);
-    if (ptm.mclassOverride && typeof ptm.mclassOverride == "object") {
-      Object.assign(mergedMclassOverride, ptm.mclassOverride);
-    }
-    const site = parsePTMModSites(ptm.modSites);
-    if (!site) continue;
-    const pos = aa2gmcoord(site, gm);
-    if (!Number.isInteger(pos)) continue;
-    const ptmClass = Object.keys(ptm.mclassOverride || {})[0];
-    custom_variants.push({
-      chr: gm.chr,
-      pos,
-      mname: ptm.modSites,
-      class: ptmClass,
-      dt: 1,
-      logValue,
-      pValue,
-      testedN: Number.isFinite(testedN) ? testedN : null,
-      controlN: Number.isFinite(controlN) ? controlN : null,
-      htmlSections: [
-        { key: "Assay", html: ptm.assayName || "NA" },
-        { key: "Cohort", html: ptm.cohortName || "NA" },
-        { key: "Protein Accession", html: ptm.proteinAccession || "NA" },
-        {
-          key: "Action",
-          label: "Launch Violin Plot",
-          callback: () => launchViolinPlot(self, ptm.assayName, ptm.cohortName, ptm.uniqueIdentifier)
-        }
-      ]
-    });
-  }
-  if (!custom_variants.length) return;
-  const mclassOverride = {
-    className: "PTM",
-    classes: mergedMclassOverride
-  };
-  for (const key in mclassOverride.classes) {
-    if (mclass[key]) Object.assign(mclass[key], mclassOverride.classes[key]);
-  }
-  const tk = {
-    type: "mds3",
-    name: "PTMs",
-    custom_variants,
-    skewerModes: [
-      {
-        type: "numeric",
-        byAttribute: "logValue",
-        label: "Log2FC Disease vs Control",
-        tooltipPrintValue: (m) => {
-          const p = Number(m.pValue);
-          return [
-            { k: "log2 fold change", v: Number.isFinite(m.logValue) ? roundValue(m.logValue, 3) : "NA" },
-            { k: "p value", v: Number.isFinite(p) && p > 0 ? p.toExponential(2) : "NA" },
-            { k: "Tested samples", v: Number.isFinite(m.testedN) ? m.testedN : "NA" },
-            { k: "Control samples", v: Number.isFinite(m.controlN) ? m.controlN : "NA" }
-          ];
-        },
-        inuse: true,
-        axisheight: 100
-      }
-    ],
-    mclassOverride
-  };
-  const arg = {
-    holder: holder.append("div"),
-    genome: self.app.opts.genome,
-    nobox: true,
-    tklst: [tk],
-    mclassOverride,
-    debugmode: self.app.opts.debug,
-    query: gm.isoform
-  };
-  const _ = await import("./block.init-NLCYAKV4.js");
-  await _.default(arg);
-}
-function parsePTMModSites(modSites) {
-  if (!modSites) return null;
-  const regex = /([A-Za-z])(\d+)/g;
-  let m;
-  while ((m = regex.exec(modSites)) !== null) {
-    const position = Number(m[2]);
-    if (!Number.isInteger(position) || position < 1) continue;
-    return position;
-  }
-  return null;
-}
-async function getGmForPTM(geneName, genomeName, isoform) {
-  if (!geneName) return null;
-  const d = await dofetch3("genelookup", {
-    body: {
-      deep: 1,
-      genome: genomeName,
-      input: geneName
-    }
-  });
-  if (d.error || !Array.isArray(d.gmlst) || !d.gmlst.length) return null;
-  const normalizedIsoform = isoform?.trim().toUpperCase();
-  const gm = d.gmlst.find((i) => i.isoform && normalizedIsoform && i.isoform.toUpperCase() == normalizedIsoform) || d.gmlst.find((i) => i.isdefault) || d.gmlst[0];
-  return gm;
-}
-function getLog2Ratio(foldChange) {
-  if (!Number.isFinite(foldChange) || foldChange <= 0) return null;
-  return Math.log2(foldChange);
-}
-async function getPlotConfig(opts) {
-  const config = structuredClone(defaultConfig);
-  if (!opts.tw) throw new Error("proteinView requires opts.tw");
-  return copyMerge(config, opts);
-}
-function makeChartBtnMenu(holder, chartsInstance) {
-  const row = holder.append("div").style("padding", "5px");
-  row.append("span").style("font-weight", "bold").text("Enter a gene name:");
-  const geneSearch = addGeneSearchbox({
-    row,
-    genome: chartsInstance.app.opts.genome,
-    tip: new Menu({ padding: "0px" }),
-    searchOnly: "gene",
-    callback: async () => {
-      if (!geneSearch.geneSymbol) throw new Error("A valid gene selection is required");
-      chartsInstance.dom.tip.hide();
-      chartsInstance.app.dispatch({
-        type: "plot_create",
-        config: {
-          chartType: "proteinView",
-          tw: {
-            term: {
-              gene: geneSearch.geneSymbol,
-              name: geneSearch.geneSymbol,
-              type: TermTypes.PROTEOME_ABUNDANCE
-            }
-          }
-        }
-      });
-    }
-  });
-}
-var proteinViewInit = getCompInit(ProteinView);
-var componentInit = proteinViewInit;
-export {
-  componentInit,
-  getPlotConfig,
-  makeChartBtnMenu,
-  proteinViewInit
-};
-//# sourceMappingURL=proteinView-AS6ZV2JT.js.map