@sjcrh/proteinpaint-client 2.185.0 → 2.186.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (848) hide show
  1. package/dist/2dmaf-F5QNP7AQ.js +1371 -0
  2. package/dist/AIProjectAdmin-ROSQHK6Q.js +827 -0
  3. package/dist/AIProjectAdmin-ROSQHK6Q.js.map +7 -0
  4. package/dist/AppHeader-STVCDLET.js +833 -0
  5. package/dist/BoxPlot-CU7MEBH7.js +1217 -0
  6. package/dist/CorrelationVolcano-OE4R2GS3.js +617 -0
  7. package/dist/DE-SR7PJPKI.js +93 -0
  8. package/dist/DEinput-PRIAIBFH.js +299 -0
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  10. package/dist/DifferentialAnalysis-UWTYK7NU.js +241 -0
  11. package/dist/Disco-IL6REGSA.js +3235 -0
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  154. package/dist/dictionary-BSKN37CP.js +109 -0
  155. package/dist/dnaMethylation-5QNEEGC6.js +36 -0
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  165. package/dist/geneExpression-NAM2UEYN.js +36 -0
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  807. /package/dist/{singlecell-VQJ2252L.js.map → singlecell-RL7V7DIC.js.map} +0 -0
  808. /package/dist/{snp-ALMKZKL2.js.map → snp-FT7HB3XN.js.map} +0 -0
  809. /package/dist/{snp.unit.spec-GJQBAHGQ.js.map → snp.unit.spec-CLYVYPPG.js.map} +0 -0
  810. /package/dist/{snplocus-WCNCMFWZ.js.map → snplocus-M5SEQGAC.js.map} +0 -0
  811. /package/dist/{spliceevent.a53ss.diagram-4Q4JF4RX.js.map → spliceevent.a53ss.diagram-EJ5CTRCZ.js.map} +0 -0
  812. /package/dist/{spliceevent.exonskip.diagram-IOYOKELT.js.map → spliceevent.exonskip.diagram-ETXMOHZ3.js.map} +0 -0
  813. /package/dist/{spliceevent.noeventdiagram-77ZCOHSF.js.map → spliceevent.noeventdiagram-S2O4ZM2Z.js.map} +0 -0
  814. /package/dist/{ssGSEA-QTXXIN4K.js.map → ssGSEA-6PMDQDTJ.js.map} +0 -0
  815. /package/dist/{ssGSEA.unit.spec-LQESATT3.js.map → ssGSEA.unit.spec-JD5T4R2N.js.map} +0 -0
  816. /package/dist/{summarizeCnvGeneexp-YKUQGDQF.js.map → summarizeCnvGeneexp-GCHNKTIU.js.map} +0 -0
  817. /package/dist/{summarizeGeneexpSurvival-ARGG5VDC.js.map → summarizeGeneexpSurvival-R2RYQZ3M.js.map} +0 -0
  818. /package/dist/{summarizeMutationCnv-FMZYT3EC.js.map → summarizeMutationCnv-LB2BIYRL.js.map} +0 -0
  819. /package/dist/{summarizeMutationDiagnosis-ZX7I46SC.js.map → summarizeMutationDiagnosis-3JUY75LM.js.map} +0 -0
  820. /package/dist/{summarizeMutationSurvival-RCFMTT43.js.map → summarizeMutationSurvival-VYLRWTCF.js.map} +0 -0
  821. /package/dist/{summary-QLL5YVI2.js.map → summary-2QQ72IEQ.js.map} +0 -0
  822. /package/dist/{summary.integration.spec-DHY6XCEJ.js.map → summary.integration.spec-XXU362UQ.js.map} +0 -0
  823. /package/dist/{summaryInput-ANCUQGIB.js.map → summaryInput-OZHZG3PV.js.map} +0 -0
  824. /package/dist/{sunburst-RDNFBOCK.js.map → sunburst-CMCJCANX.js.map} +0 -0
  825. /package/dist/{survival-BG7QV52L.js.map → survival-EBD4DHO7.js.map} +0 -0
  826. /package/dist/{survival-WSN36OQE.js.map → survival-ISLRRPKU.js.map} +0 -0
  827. /package/dist/{survival.integration.spec-37KAJ5IK.js.map → survival.integration.spec-FS7V4OXK.js.map} +0 -0
  828. /package/dist/{svgraph-A5WGHW4S.js.map → svgraph-KGLNUM7W.js.map} +0 -0
  829. /package/dist/{svmr-CYRHHWZF.js.map → svmr-NXZ5VLKH.js.map} +0 -0
  830. /package/dist/{table-VHO7E5PI.js.map → table-ISOQOI6C.js.map} +0 -0
  831. /package/dist/{termCollection-HSVSH7TJ.js.map → termCollection-7ZSU3I45.js.map} +0 -0
  832. /package/dist/{termCollection-E4Q6GLXN.js.map → termCollection-V2A5BDQB.js.map} +0 -0
  833. /package/dist/{termCollection.unit.spec-ZCE3TUMS.js.map → termCollection.unit.spec-6VLCJGOU.js.map} +0 -0
  834. /package/dist/{tk-GPRHDN4K.js.map → tk-6AB6XYIE.js.map} +0 -0
  835. /package/dist/{tp.ui-LTUA3FSL.js.map → tp.ui-2O4UW5N7.js.map} +0 -0
  836. /package/dist/{tvs.dt-G43PAAKD.js.map → tvs.dt-CY6TOQVB.js.map} +0 -0
  837. /package/dist/{tvs.dtcnv.categorical-UHDS2TGZ.js.map → tvs.dtcnv.categorical-AYQ432TW.js.map} +0 -0
  838. /package/dist/{tvs.dtcnv.continuous-ZNGYQKTD.js.map → tvs.dtcnv.continuous-XVDL6SG3.js.map} +0 -0
  839. /package/dist/{tvs.dtfusion-JBEEUDUS.js.map → tvs.dtfusion-V3AV7A6Q.js.map} +0 -0
  840. /package/dist/{tvs.dtsnvindel-XXN5Q7RN.js.map → tvs.dtsnvindel-XM3NXIT7.js.map} +0 -0
  841. /package/dist/{tvs.dtsv-MO6L7HHV.js.map → tvs.dtsv-Z2GYRINW.js.map} +0 -0
  842. /package/dist/{tvs.samplelst-HKY6UUJM.js.map → tvs.samplelst-C4FB63G7.js.map} +0 -0
  843. /package/dist/{tvs.termCollection-TY6FPL25.js.map → tvs.termCollection-VHTSC2ST.js.map} +0 -0
  844. /package/dist/{violin-YHE3WSGR.js.map → violin-KGGTUQFF.js.map} +0 -0
  845. /package/dist/{violin.integration.spec-F2UD7BHC.js.map → violin.integration.spec-5EW6PLJX.js.map} +0 -0
  846. /package/dist/{violin.interactivity-LVDTDEPQ.js.map → violin.interactivity-RI4RURGO.js.map} +0 -0
  847. /package/dist/{violin.renderer-IIEIUGRI.js.map → violin.renderer-EWU2IFZE.js.map} +0 -0
  848. /package/dist/{vocabulary-WQRYXBRO.js.map → vocabulary-VLIGC7OP.js.map} +0 -0
@@ -1,2248 +0,0 @@
1
- import {
2
- blocklazyload
3
- } from "./chunk-HROKXT4K.js";
4
- import {
5
- hicParseFile
6
- } from "./chunk-ST644IDH.js";
7
- import {
8
- AppBase,
9
- ColorScale,
10
- axisstyle,
11
- first_genetrack_tolist,
12
- font,
13
- newpane,
14
- showErrorsWithCounter,
15
- tkt
16
- } from "./chunk-YWUVCXFS.js";
17
- import "./chunk-HJ6L54YS.js";
18
- import "./chunk-3QBZ2Y77.js";
19
- import {
20
- Menu
21
- } from "./chunk-HYOEWQ5P.js";
22
- import "./chunk-FN5XPUPH.js";
23
- import "./chunk-G6O3URDN.js";
24
- import "./chunk-LSEFWW72.js";
25
- import "./chunk-KWM6B3NL.js";
26
- import "./chunk-UCLS2SVB.js";
27
- import {
28
- dofetch3
29
- } from "./chunk-6ZCHECOT.js";
30
- import {
31
- StoreBase,
32
- getAppInit,
33
- getCompInit,
34
- getStoreInit
35
- } from "./chunk-MVTCBVSX.js";
36
- import "./chunk-2K5DSRBJ.js";
37
- import "./chunk-X4NI4JLQ.js";
38
- import "./chunk-L4QG7XZE.js";
39
- import "./chunk-DQC5FFGV.js";
40
- import "./chunk-UWYCEYML.js";
41
- import "./chunk-7UHUOC6F.js";
42
- import "./chunk-ZYY54HBU.js";
43
- import "./chunk-EGWVYY7K.js";
44
- import {
45
- bplen
46
- } from "./chunk-AMYSEKPF.js";
47
- import "./chunk-TV74I3Y5.js";
48
- import "./chunk-KSGA62R2.js";
49
- import {
50
- axisBottom,
51
- axisRight
52
- } from "./chunk-LOZEKOES.js";
53
- import "./chunk-TOU7EVFQ.js";
54
- import {
55
- format,
56
- linear
57
- } from "./chunk-OAWQ6LOO.js";
58
- import "./chunk-KYBIQBXE.js";
59
- import {
60
- pointer_default,
61
- select_default
62
- } from "./chunk-I6Y4O3RR.js";
63
- import "./chunk-OMR2DT66.js";
64
- import "./chunk-HFNDKYVF.js";
65
-
66
- // tracks/hic/HicStore.ts
67
- var HicStore = class _HicStore extends StoreBase {
68
- constructor(opts) {
69
- super(opts);
70
- this.views = ["genome", "chrpair", "detail", "horizontal"];
71
- this.type = _HicStore.type;
72
- this.defaultState = {
73
- defaultNmeth: "NONE",
74
- loading: true,
75
- minBinNum_bp: 200,
76
- minFragSpan: 200,
77
- initialBinNum: 20,
78
- settings: {
79
- widthHeightPx: 800
80
- }
81
- };
82
- }
83
- static {
84
- this.type = "store";
85
- }
86
- init() {
87
- this.state = Object.assign({}, this.defaultState, this.state);
88
- }
89
- };
90
- var hicStoreInit = getStoreInit(HicStore);
91
- HicStore.prototype.actions = {
92
- view_create(action) {
93
- if (!action.view) throw Error("view_create: missing view");
94
- if (!this.views.some((v) => v == action.view)) throw Error(`view_create: unknown view = ${action.view}`);
95
- this.state.currView = action.view;
96
- const opts = Object.assign(this.state, action.config);
97
- this.state = opts;
98
- },
99
- view_update(action) {
100
- if (action.view) {
101
- if (!this.views.some((v) => v == action.view)) throw Error(`view_update: unknown view = ${action.view}`);
102
- const opts = Object.assign(this.state[action.view], action.config);
103
- this.state[action.view] = opts;
104
- } else {
105
- const opts = Object.assign(this.state, action.config);
106
- this.state = opts;
107
- }
108
- },
109
- loading_active(action) {
110
- this.state.loading = action.active;
111
- }
112
- };
113
-
114
- // tracks/hic/dom/LoadingOverlay.ts
115
- var LoadingOverlay = class _LoadingOverlay {
116
- constructor(opts) {
117
- this.hasStatePreMain = true;
118
- this.type = _LoadingOverlay.type;
119
- this.app = opts.app;
120
- this.loadingDiv = opts.loadingDiv;
121
- }
122
- static {
123
- this.type = "loadingOverlay";
124
- }
125
- reactsTo(action) {
126
- if (action.type.startsWith("loading")) return true;
127
- else return false;
128
- }
129
- getState(appState) {
130
- return appState;
131
- }
132
- init() {
133
- this.loadingDiv.append("div").attr("class", "sjpp-spinner").style("display", "");
134
- }
135
- main(appState) {
136
- const loading = this.app.getState(appState).loading;
137
- this.loadingDiv.style("display", loading ? "" : "none");
138
- }
139
- };
140
- var loadingInit = getCompInit(LoadingOverlay);
141
-
142
- // tracks/hic/dom/ColorizeElement.ts
143
- var ColorizeElement = class {
144
- colorizeElement(xCoord, yCoord, v, obj, width, height, bpMinV, bpMaxV, currView) {
145
- if (v >= 0) {
146
- const p = v >= bpMaxV ? 0 : v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV - v) / bpMaxV);
147
- const positiveFill = `rgb(255, ${p}, ${p})`;
148
- if (currView === "genome") {
149
- obj.ctx.fillStyle = positiveFill;
150
- obj.ctx2.fillStyle = positiveFill;
151
- } else {
152
- obj.fillStyle = positiveFill;
153
- }
154
- } else {
155
- const p = v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV + v) / bpMaxV);
156
- const negativeFill = `rgb(${p}, ${p}, 255)`;
157
- if (currView === "genome") {
158
- obj.ctx.fillStyle = negativeFill;
159
- obj.ctx2.fillStyle = negativeFill;
160
- } else {
161
- obj.fillStyle = negativeFill;
162
- }
163
- }
164
- if (currView === "genome") {
165
- obj.ctx.fillRect(yCoord, xCoord, width, height);
166
- obj.ctx2.fillRect(xCoord, yCoord, width, height);
167
- } else {
168
- obj.fillRect(xCoord, yCoord, width, height);
169
- }
170
- }
171
- };
172
-
173
- // tracks/hic/data/Resolution.ts
174
- var Resolution = class {
175
- constructor(error) {
176
- this.error = error;
177
- }
178
- getResolution(state, hic) {
179
- if (state.currView == "genome") return hic["bpresolution"][0];
180
- if (state.currView == "chrpair") {
181
- const resolution = this.getChrPairResolution(hic, state.x, state.y, state.minBinNum_bp);
182
- return resolution;
183
- } else if (state.currView == "detail") {
184
- const maxBpWidth = Math.max(state.x.stop - state.x.start, state.y.stop - state.y.start);
185
- let resolution = this.findResFromArray(maxBpWidth, state.minBinNum_bp, hic.bpresolution);
186
- if (resolution == null && !hic.enzyme) {
187
- resolution = hic.bpresolution[hic.bpresolution.length - 1];
188
- }
189
- return resolution;
190
- } else {
191
- this.error(`Unknown view: ${state.currView}`);
192
- throw `Unknown view: ${state.currView}`;
193
- }
194
- }
195
- getChrPairResolution(hic, x, y, minBinNum_bp) {
196
- const chrxlen = hic.genome.chrlookup[x.chr.toUpperCase()].len;
197
- const chrylen = hic.genome.chrlookup[y.chr.toUpperCase()].len;
198
- const maxchrlen = Math.max(chrxlen, chrylen);
199
- const resolution = this.findResFromArray(maxchrlen, minBinNum_bp, hic.bpresolution);
200
- if (resolution == null) {
201
- this.error(`No suitable resolution for ${x.chr}-${y.chr} pair.`);
202
- return;
203
- }
204
- return resolution;
205
- }
206
- findResFromArray(max, defaultValue, resolutionArray, returnNum) {
207
- let resolution = null;
208
- for (const res of resolutionArray) {
209
- if (max / res > defaultValue) {
210
- resolution = res;
211
- break;
212
- }
213
- }
214
- if (returnNum && resolution == null) {
215
- resolution = resolutionArray[resolutionArray.length - 1];
216
- }
217
- return resolution;
218
- }
219
- getDefaultViewSpan(hic, x, y, initialBinNum, minBinNum_bp) {
220
- const chrpairResolution = this.getChrPairResolution(hic, x, y, minBinNum_bp);
221
- if (!chrpairResolution) return;
222
- return chrpairResolution * initialBinNum;
223
- }
224
- };
225
-
226
- // tracks/hic/data/Positions.ts
227
- var Positions = class {
228
- constructor(error, minBinNum_bp) {
229
- this.error = error;
230
- this.resolution = new Resolution(this.error);
231
- this.minBinNum_bp = minBinNum_bp;
232
- }
233
- /**
234
- *
235
- * @param x x coordinate of pointer
236
- * @param y y coordinate of pointer
237
- * @param binpx
238
- * @param chrx x chr from state
239
- * @param chry y chr from state
240
- * @param hic
241
- * @param initialBinNum Set in the state
242
- * @returns
243
- */
244
- setPosition(x, y, binpx, chrx, chry, hic, initialBinNum) {
245
- const resolution = this.resolution.getChrPairResolution(hic, chrx, chry, this.minBinNum_bp);
246
- const viewrangebpw = resolution * initialBinNum;
247
- let coordx = Math.max(1, Math.floor(x * resolution / binpx) - viewrangebpw / 2);
248
- let coordy = Math.max(1, Math.floor(y * resolution / binpx) - viewrangebpw / 2);
249
- {
250
- const lenx = hic.genome.chrlookup[chrx.chr.toUpperCase()].len;
251
- if (coordx + viewrangebpw >= lenx) {
252
- coordx = lenx - viewrangebpw;
253
- }
254
- const leny = hic.genome.chrlookup[chry.chr.toUpperCase()].len;
255
- if (coordy + viewrangebpw > leny) {
256
- coordy = leny - viewrangebpw;
257
- }
258
- }
259
- const xObj = {
260
- chr: chrx.chr,
261
- start: coordx,
262
- stop: coordx + viewrangebpw
263
- };
264
- const yObj = {
265
- chr: chry.chr,
266
- start: coordy,
267
- stop: coordy + viewrangebpw
268
- };
269
- return [xObj, yObj];
270
- }
271
- };
272
-
273
- // tracks/hic/data/GridElementsFormattedData.ts
274
- var GridElementsFormattedData = class {
275
- /**
276
- * Format the data for the grid elements.
277
- * @param items The data to format.
278
- * @param binpx The bin size in pixels.
279
- * @param resolution The resolution.
280
- * @param isFirstChrX Whether the first chromosome is X. Used for chrpair view.
281
- * @param isIntraChr Whether the data is intra-chromosomal. Used for chrpair view
282
- * @returns The formatted data.
283
- */
284
- formatData(view, items, binpx, resolution, isFirstChrX, isIntraChr) {
285
- const formattedData = [];
286
- for (const [xCoord, yCoord, value] of items) {
287
- const xPx = Math.floor(xCoord / resolution) * binpx;
288
- const yPx = Math.floor(yCoord / resolution) * binpx;
289
- if (view == "genome") {
290
- formattedData.push([xPx, yPx, value]);
291
- }
292
- if (view == "chrpair") {
293
- const x = isFirstChrX ? xPx : yPx;
294
- const y = isFirstChrX ? yPx : xPx;
295
- formattedData.push([x, y, value]);
296
- if (isIntraChr) {
297
- formattedData.push([y, x, value]);
298
- }
299
- }
300
- }
301
- return formattedData;
302
- }
303
- };
304
-
305
- // tracks/hic/data/FirstChrX.ts
306
- var FirstChrX = class {
307
- constructor(chrorder, chrx, chry) {
308
- this.chrorder = chrorder;
309
- this.chrx = chrx;
310
- this.chry = chry;
311
- }
312
- isFirstX() {
313
- if (this.chrx == this.chry) return true;
314
- return this.chrorder.indexOf(this.chrx) < this.chrorder.indexOf(this.chry);
315
- }
316
- };
317
-
318
- // tracks/hic/chrpair/ChrPairView.ts
319
- var ChrPairView = class {
320
- constructor(opts) {
321
- this.binpx = 1;
322
- /** padding on the ends of x/y chr coordinate axes */
323
- this.axispad = 10;
324
- this.axisLabelFontSize = 15;
325
- this.calcResolution = null;
326
- this.data = [];
327
- this.app = opts.app;
328
- this.hic = opts.hic;
329
- this.plotDiv = opts.plotDiv;
330
- this.items = opts.items;
331
- this.parent = opts.parent;
332
- this.chrxlen = this.hic.genome.chrlookup[this.parent("state").x.chr.toUpperCase()].len;
333
- this.chrylen = this.hic.genome.chrlookup[this.parent("state").y.chr.toUpperCase()].len;
334
- this.maxchrlen = Math.max(this.chrxlen, this.chrylen);
335
- this.colorizeElement = new ColorizeElement();
336
- this.positions = new Positions(opts.error, this.parent("state").minBinNum_bp);
337
- this.formattedData = new GridElementsFormattedData();
338
- }
339
- setDefaultBinpx() {
340
- if (this.calcResolution == null) return;
341
- while (this.binpx * this.maxchrlen / this.calcResolution < 600) {
342
- this.binpx++;
343
- }
344
- }
345
- renderAxes() {
346
- if (this.calcResolution == null) return;
347
- const svgY = this.plotDiv.yAxis.append("svg");
348
- const h = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
349
- svgY.attr("width", 100).attr("height", this.axispad * 2 + h);
350
- svgY.append("g").attr("data-testid", "sjpp-chrpair-svg-y").attr("transform", "translate(80," + (this.axispad + h / 2) + ")").append("text").text(this.parent("state").y.chr).attr("text-anchor", "middle").attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("dominant-baseline", "central").attr("transform", "rotate(90)");
351
- axisstyle({
352
- axis: svgY.append("g").attr("transform", `translate(1, ${this.axispad})`).call(axisRight(linear().domain([0, this.chrylen]).range([0, h])).tickFormat(format(".2s"))),
353
- showline: true
354
- });
355
- const svgX = this.plotDiv.xAxis.append("svg").style("margin-top", "-4px");
356
- const w = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
357
- svgX.attr("height", 100).attr("width", this.axispad * 2 + w);
358
- svgX.append("text").attr("data-testid", "sjpp-chrpair-svg-x").text(this.parent("state").x.chr).attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("x", this.axispad + w / 2).attr("text-anchor", "middle").attr("y", 60);
359
- axisstyle({
360
- axis: svgX.append("g").attr("transform", "translate(" + this.axispad + ",1)").call(axisBottom(linear().domain([0, this.chrxlen]).range([0, w])).tickFormat(format(".2s"))),
361
- showline: true
362
- });
363
- }
364
- renderCanvas() {
365
- const initDetailView = this.initDetailView.bind(this);
366
- this.canvas = this.plotDiv.plot.append("canvas").attr("data-testid", "sjpp-chrpair-canvas").style("margin", this.axispad + "px").on("click", async function(event) {
367
- const [x, y] = pointer_default(event, this);
368
- initDetailView(x, y);
369
- }).node();
370
- this.canvas.width = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
371
- this.canvas.height = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
372
- this.ctx = this.canvas.getContext("2d");
373
- }
374
- initDetailView(x, y) {
375
- const [xObj, yObj] = this.positions.setPosition(
376
- x,
377
- y,
378
- this.binpx,
379
- this.parent("state").x,
380
- this.parent("state").y,
381
- this.hic,
382
- this.parent("state").initialBinNum
383
- );
384
- this.app.dispatch({
385
- type: "view_create",
386
- view: "detail",
387
- config: {
388
- x: xObj,
389
- y: yObj
390
- }
391
- });
392
- }
393
- render() {
394
- this.calcResolution = this.parent("calcResolution");
395
- this.setDefaultBinpx();
396
- this.renderAxes();
397
- this.renderCanvas();
398
- this.update(this.items);
399
- }
400
- update(items) {
401
- this.items = items;
402
- const firstisx = new FirstChrX(this.hic.chrorder, this.parent("state").x.chr, this.parent("state").y.chr).isFirstX();
403
- const isintrachr = this.parent("state").x.chr === this.parent("state").y.chr;
404
- this.data = this.formattedData.formatData(
405
- "chrpair",
406
- items.items,
407
- this.binpx,
408
- this.calcResolution,
409
- firstisx,
410
- isintrachr
411
- );
412
- this.ctx.clearRect(0, 0, this.canvas.width, this.canvas.height);
413
- for (const [x, y, v] of this.data) {
414
- this.colorizeElement.colorizeElement(
415
- x,
416
- y,
417
- v,
418
- this.ctx,
419
- this.binpx,
420
- //width
421
- this.binpx,
422
- //height
423
- this.parent("min"),
424
- this.parent("max"),
425
- "chrpair"
426
- );
427
- }
428
- this.app.dispatch({ type: "loading_active", active: false });
429
- }
430
- };
431
-
432
- // tracks/hic/horizontal/HorizontalView.ts
433
- var HorizontalView = class {
434
- constructor(opts) {
435
- /** Defaults*/
436
- this.maxPercentage = 5;
437
- this.subPanelPxWidth = 600;
438
- this.borderColor = "rgba(200,0,0,.1)";
439
- this.app = opts.app;
440
- this.hic = opts.hic;
441
- this.plotDiv = opts.plotDiv;
442
- this.items = opts.items;
443
- this.parent = opts.parent;
444
- }
445
- setRunPpTracks() {
446
- const tracks = [
447
- {
448
- type: "hicstraw",
449
- file: this.hic.file,
450
- url: this.hic.url,
451
- name: this.hic.name,
452
- enzyme: this.hic.enzyme,
453
- maxpercentage: this.maxPercentage,
454
- pyramindup: 1
455
- }
456
- ];
457
- if (this.hic.tklst) {
458
- for (const t of this.hic.tklst) {
459
- tracks.push(t);
460
- }
461
- }
462
- first_genetrack_tolist(this.hic.genome, tracks);
463
- return tracks;
464
- }
465
- setRunPpArgs(tracks) {
466
- const arg = {
467
- holder: this.plotDiv.plot,
468
- hostURL: this.hic.hostURL,
469
- jwt: this.hic.jwt,
470
- genome: this.hic.genome,
471
- nobox: 1,
472
- tklst: tracks
473
- };
474
- const state = this.parent("state");
475
- if (state.x.chr == state.y.chr && Math.max(state.x.start, state.y.start) < Math.min(state.x.stop, state.y.stop)) {
476
- arg["chr"] = state.x.chr;
477
- arg["start"] = Math.min(state.x.start, state.y.start);
478
- arg["stop"] = Math.max(state.x.stop, state.y.stop);
479
- } else {
480
- arg["chr"] = state.x.chr;
481
- arg["start"] = state.x.start;
482
- arg["stop"] = state.x.stop;
483
- arg["width"] = this.subPanelPxWidth;
484
- arg["subpanels"] = [
485
- {
486
- chr: state.y.chr,
487
- start: state.y.start,
488
- stop: state.y.stop,
489
- width: this.subPanelPxWidth,
490
- leftpad: 10,
491
- leftborder: this.borderColor
492
- }
493
- ];
494
- }
495
- return arg;
496
- }
497
- render() {
498
- const tracks = this.setRunPpTracks();
499
- const arg = this.setRunPpArgs(tracks);
500
- blocklazyload(arg);
501
- }
502
- // update() {
503
- // //Not required.
504
- // //If controls are added back. Implement changes here.
505
- // }
506
- };
507
-
508
- // tracks/hic/detail/DetailBlock.ts
509
- var DetailBlock = class {
510
- constructor(app, hic, blockwidth, bbmargin, holder, isYblock) {
511
- /** Defaults */
512
- this.leftheadw = 20;
513
- this.rightheadw = 40;
514
- this.lpad = 1;
515
- this.rpad = 1;
516
- this.firstRender = true;
517
- this.app = app;
518
- this.hic = hic;
519
- this.width = blockwidth;
520
- this.bbmargin = bbmargin;
521
- this.holder = holder;
522
- this.isYblock = isYblock;
523
- this.bbw = this.leftheadw + this.lpad + this.width + this.rpad + this.rightheadw + 2 * this.bbmargin;
524
- this.defaultLeft = this.bbmargin + this.leftheadw + this.lpad;
525
- this.defaultTop = this.bbmargin + this.rightheadw + this.rpad;
526
- }
527
- setArgs(chrObj) {
528
- const runPpArgs = {
529
- hostURL: this.hic.hostURL,
530
- genome: this.hic.genome,
531
- holder: this.holder,
532
- noresize: true,
533
- nobox: true,
534
- butrowbottom: true,
535
- style: {
536
- margin: `${this.bbmargin}px`
537
- },
538
- width: this.width,
539
- leftheadw: this.leftheadw,
540
- chr: chrObj.chr,
541
- start: chrObj.start,
542
- stop: chrObj.stop,
543
- rightheadw: this.rightheadw,
544
- tklst: [],
545
- rotated: this.isYblock,
546
- showreverse: this.isYblock
547
- };
548
- first_genetrack_tolist(this.hic.genome, runPpArgs.tklst);
549
- return runPpArgs;
550
- }
551
- setMethods(canvasHolder, canvas, sheath) {
552
- const runPpMethods = {
553
- onloadalltk_always: () => {
554
- this.onload(canvasHolder, canvas, sheath);
555
- },
556
- onpanning: (xoff) => this.onpanning(xoff, canvas)
557
- };
558
- if (this.isYblock) {
559
- runPpMethods["onsetheight"] = (bbh) => {
560
- this.holder.transition().style("left", `${bbh + this.bbmargin + 30}px`);
561
- };
562
- }
563
- return runPpMethods;
564
- }
565
- onload(canvasHolder, canvas, sheath) {
566
- this.bbw = this.block.leftheadw + this.block.lpad + this.block.width + this.block.rpad + this.block.rightheadw + 2 * this.bbmargin;
567
- if (this.isYblock) {
568
- sheath.transition().style("height", `${this.bbw}px`);
569
- canvasHolder.style("height", `${this.bbw}px`);
570
- } else canvasHolder.style("width", `${this.bbw}px`);
571
- if (this.isYblock) {
572
- this.defaultTop = this.bbmargin + this.block.rightheadw + this.block.rpad;
573
- canvas.style("top", `${this.defaultTop}px`);
574
- } else {
575
- this.defaultLeft = this.bbmargin + this.block.leftheadw + this.block.lpad;
576
- canvas.style("left", `${this.defaultLeft}px`);
577
- }
578
- const config = {
579
- [this.isYblock ? "y" : "x"]: {
580
- chr: this.block.rglst[0].chr,
581
- start: this.block.rglst[0].start,
582
- stop: this.block.rglst[0].stop
583
- }
584
- };
585
- if (this.firstRender == false) {
586
- this.app.dispatch({
587
- type: "view_update",
588
- config
589
- });
590
- } else {
591
- this.firstRender = false;
592
- }
593
- }
594
- onpanning(xoff, canvas) {
595
- if (!this.isYblock) canvas.style("left", `${xoff + this.defaultLeft}px`);
596
- else canvas.style("top", `${-xoff + this.defaultTop}px`);
597
- }
598
- async loadBlock(chrObj, canvasHolder, canvas, sheath) {
599
- const runPpArgs = this.setArgs(chrObj);
600
- const runPpMethods = this.isYblock ? this.setMethods(canvasHolder, canvas, sheath) : this.setMethods(canvasHolder, canvas);
601
- const args = Object.assign(runPpArgs, runPpMethods);
602
- await blocklazyload(args).then(async (block) => {
603
- this.block = block;
604
- });
605
- }
606
- };
607
-
608
- // tracks/hic/data/DetailDataFetcher.ts
609
- var DetailDataFetcher = class {
610
- constructor(errList) {
611
- this.obj = {
612
- rglst: []
613
- };
614
- this.errList = errList;
615
- }
616
- isFragData(hic, resolution) {
617
- if (resolution != null) return;
618
- if (!hic.enzyme) {
619
- resolution = hic.bpresolution[hic.bpresolution.length - 1];
620
- return;
621
- }
622
- }
623
- formatFragArgs(enzymefile, chr) {
624
- const arg = {
625
- getdata: 1,
626
- getBED: 1,
627
- file: enzymefile,
628
- rglst: [chr]
629
- };
630
- return arg;
631
- }
632
- /**
633
- * @param arg Formated obj from either fn above
634
- * @param errList
635
- * @returns
636
- */
637
- async getBedData(arg) {
638
- try {
639
- return await dofetch3("tkbedj", { method: "POST", body: JSON.stringify(arg) });
640
- } catch (e) {
641
- this.errList.push(e.message || e);
642
- if (e.stack) console.error(e.stack);
643
- }
644
- }
645
- async getXFragData(hic, resolution, chrx) {
646
- this.isFragData(hic, resolution);
647
- if (!hic.enzymefile) return;
648
- const reqArgs = this.formatFragArgs(hic.enzymefile, chrx);
649
- return await this.getBedData(reqArgs);
650
- }
651
- async getYFragData(hic, chry) {
652
- const reqArgs = this.formatFragArgs(hic.enzymefile, chry);
653
- return await this.getBedData(reqArgs);
654
- }
655
- /**
656
- * Separate request from data fetch
657
- * Returns the additional fragment data
658
- * @param fragCoords
659
- */
660
- async fetchData(hic, detailView, resolution, x, y, fragCoords) {
661
- const fragStrawArgs = {
662
- matrixType: detailView.matrixType,
663
- file: hic.file,
664
- url: hic.url,
665
- pos1: this.determinePosition(hic, x, fragCoords?.x),
666
- pos2: this.determinePosition(hic, y, fragCoords?.y),
667
- nmeth: detailView.nmeth,
668
- resolution
669
- };
670
- if (fragCoords) fragStrawArgs["isfrag"] = true;
671
- try {
672
- const data = dofetch3("hicdata?", {
673
- method: "POST",
674
- body: JSON.stringify(fragStrawArgs)
675
- });
676
- if (data.error) {
677
- this.errList.push(data.error);
678
- }
679
- return data;
680
- } catch (e) {
681
- this.errList.push(e.message || e);
682
- if (e.stack) console.error(e.stack);
683
- }
684
- }
685
- determinePosition(hic, chr, fragCoord) {
686
- if (fragCoord) {
687
- return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${fragCoord.start}:${fragCoord.stop}`;
688
- } else {
689
- return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${chr.start}:${chr.stop}`;
690
- }
691
- }
692
- };
693
-
694
- // tracks/hic/data/ParseFragData.ts
695
- var ParseFragData = class {
696
- constructor(errLst, items) {
697
- this.id2coord = /* @__PURE__ */ new Map();
698
- this.min = null;
699
- this.max = null;
700
- this.items = [];
701
- this.errLst = errLst;
702
- for (const i of items) {
703
- if (!i.rest || !i.rest[0]) {
704
- this.errLst.push("items[].rest data problem");
705
- }
706
- const id = Number.parseInt(i.rest[0]);
707
- if (Number.isNaN(id)) {
708
- this.errLst.push(`${i.start}.${i.stop} invalid fragment id: ${i.rest[0]}`);
709
- }
710
- this.id2coord.set(id, [i.start, i.stop]);
711
- if (this.min == null) {
712
- this.min = id;
713
- this.max = id;
714
- } else {
715
- this.min = Math.min(this.min, id);
716
- this.max = Math.max(this.max, id);
717
- }
718
- }
719
- }
720
- };
721
-
722
- // tracks/hic/data/DetailDataMapper.ts
723
- var DetailDataMapper = class {
724
- constructor(hic, errList, parent) {
725
- this.frag = {
726
- x: {},
727
- y: {}
728
- };
729
- this.hic = hic;
730
- this.errList = errList;
731
- this.dataFetcher = new DetailDataFetcher(errList);
732
- this.parent = parent;
733
- }
734
- async getFragData(chrx, chry) {
735
- try {
736
- const xFragData = await this.dataFetcher.getXFragData(this.hic, this.parent("calcResolution"), chrx);
737
- if (xFragData) {
738
- if (!xFragData.items) {
739
- this.errList.push(`No fragment data returned for ${chrx.chr}:${chrx.start}-${chrx.stop}`);
740
- return;
741
- }
742
- const xParse = new ParseFragData(this.errList, xFragData.items);
743
- if (this.errList.length) return;
744
- this.frag.x = {
745
- id2coord: xParse.id2coord,
746
- start: xParse.min,
747
- stop: xParse.max
748
- };
749
- const yFragData = await this.dataFetcher.getYFragData(this.hic, chry);
750
- if (this.errList.length) return;
751
- if (yFragData) {
752
- if (!yFragData.items) {
753
- this.errList.push(`No fragment data returned for ${chry.chr}:${chry.start}-${chry.stop}`);
754
- return;
755
- }
756
- const yParse = new ParseFragData(this.errList, yFragData.items);
757
- if (this.errList.length) return;
758
- this.frag.y = {
759
- id2coord: /* @__PURE__ */ new Map(),
760
- start: yParse.min,
761
- stop: yParse.max
762
- };
763
- this.determineMap(yParse.id2coord, chrx, chry);
764
- }
765
- }
766
- } catch (e) {
767
- this.errList.push(e.message || e);
768
- if (e.stack) console.error(e.stack);
769
- }
770
- }
771
- determineMap(map, chrx, chry) {
772
- if (chrx.chr == chry.chr) {
773
- for (const [id, pos] of map) {
774
- this.frag.x["id2coord"].set(id, pos);
775
- }
776
- this.frag.y["id2coord"] = this.frag.x["id2coord"];
777
- } else {
778
- this.frag.y["id2coord"] = map;
779
- }
780
- }
781
- async getData(chrx, chry, fragCoords) {
782
- return await this.dataFetcher.fetchData(
783
- this.hic,
784
- this.parent("state")["detail"],
785
- this.parent("calcResolution"),
786
- chrx,
787
- chry,
788
- fragCoords
789
- );
790
- }
791
- };
792
-
793
- // tracks/hic/data/DetailCoodinates.ts
794
- var DetailCoordinates = class {
795
- constructor(hic, errlist) {
796
- this.hic = hic;
797
- this.errlist = errlist;
798
- }
799
- getCoordinates(chrx, chry, data, resolution, widthHeightPx, fragData) {
800
- const isFirstX = new FirstChrX(this.hic.chrorder, chrx.chr, chry.chr).isFirstX();
801
- const isintrachr = chrx.chr == chry.chr;
802
- const xpxbp = widthHeightPx / (chrx.stop - chrx.start);
803
- const ypxbp = widthHeightPx / (chry.stop - chry.start);
804
- const list = this.calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData);
805
- return list;
806
- }
807
- calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData) {
808
- const list = [];
809
- for (const [xCoord, yCoord, value] of data.items) {
810
- let coord1, coord2, span1, span2;
811
- if (fragData) {
812
- const idx_start = isFirstX ? xCoord : yCoord;
813
- const idy_start = isFirstX ? yCoord : xCoord;
814
- if (fragData.x.id2coord.has(idx_start)) {
815
- const [a, b] = fragData.x.id2coord.get(idx_start);
816
- coord1 = a;
817
- span1 = b - a;
818
- } else {
819
- this.errlist.push(`[x id error] x: ${idx_start} y: ${idy_start}`);
820
- continue;
821
- }
822
- {
823
- const id_stop = idx_start + resolution;
824
- if (fragData.x.id2coord.has(id_stop)) {
825
- const ab = fragData.x.id2coord.get(id_stop);
826
- span1 = ab[1] - coord1;
827
- }
828
- }
829
- if (fragData.y.id2coord.has(idy_start)) {
830
- const [a, b] = fragData.y.id2coord.get(idy_start);
831
- coord2 = a;
832
- span2 = b - a;
833
- } else {
834
- this.errlist.push(`[y id error] x: ${idx_start} y: ${idy_start}`);
835
- continue;
836
- }
837
- {
838
- const id_stop = idy_start + resolution;
839
- if (fragData.y.id2coord.has(id_stop)) {
840
- const ab = fragData.y.id2coord.get(id_stop);
841
- span2 = ab[1] - coord2;
842
- }
843
- }
844
- } else {
845
- coord1 = isFirstX ? xCoord : yCoord;
846
- coord2 = isFirstX ? yCoord : xCoord;
847
- span1 = resolution;
848
- span2 = resolution;
849
- }
850
- if (isintrachr) {
851
- if (coord1 > chrx.start - span1 && coord1 < chrx.stop && coord2 > chry.start - span2 && coord2 < chry.stop) {
852
- list.push([
853
- Math.floor((coord1 - chrx.start) * xpxbp),
854
- Math.floor((coord2 - chry.start) * ypxbp),
855
- Math.ceil(span1 * xpxbp),
856
- Math.ceil(span2 * ypxbp),
857
- value
858
- ]);
859
- }
860
- if (coord2 > chrx.start - span2 && coord2 < chrx.stop && coord1 > chry.start && coord1 < chry.stop) {
861
- list.push([
862
- Math.floor((coord2 - chrx.start) * xpxbp),
863
- Math.floor((coord1 - chry.start) * ypxbp),
864
- Math.ceil(span2 * xpxbp),
865
- Math.ceil(span1 * ypxbp),
866
- value
867
- ]);
868
- }
869
- continue;
870
- }
871
- list.push([
872
- Math.floor((coord1 - chrx.start) * xpxbp),
873
- Math.floor((coord2 - chry.start) * ypxbp),
874
- Math.ceil(span1 * xpxbp),
875
- Math.ceil(span2 * ypxbp),
876
- value
877
- ]);
878
- }
879
- return list;
880
- }
881
- };
882
-
883
- // tracks/hic/detail/DetailView.ts
884
- var DetailView = class {
885
- constructor(opts) {
886
- this.calcResolution = null;
887
- /** Defaults **/
888
- this.binpx = 2;
889
- this.bbmargin = 1;
890
- this.app = opts.app;
891
- this.hic = opts.hic;
892
- this.plotDiv = opts.plotDiv;
893
- this.sheath = opts.plotDiv.yAxis.append("div").style("position", "relative").style("width", "200px").style("height", "800px");
894
- this.rotor = this.sheath.append("div").style("position", "absolute").style("bottom", "0px").style("transform", "rotate(-90deg)").style("transform-origin", "left bottom");
895
- this.data = opts.data;
896
- this.parent = opts.parent;
897
- this.errList = this.parent("errList");
898
- this.resolution = new Resolution(opts.error);
899
- this.colorizeElement = new ColorizeElement();
900
- this.viewRangeBpW = this.resolution.getDefaultViewSpan(
901
- this.hic,
902
- this.parent("state").x,
903
- this.parent("state").y,
904
- this.parent("state").initialBinNum,
905
- this.parent("state").minBinNum_bp
906
- );
907
- this.dataMapper = new DetailDataMapper(this.hic, opts.error, opts.parent);
908
- this.coordinates = new DetailCoordinates(this.hic, this.errList);
909
- }
910
- renderCanvas(blockwidth) {
911
- this.canvasHolder = this.plotDiv.plot.append("div").style("position", "relative").style("width", `${this.xBlock.bbw}px`).style("height", `${this.yBlock.bbw}px`).style("overflow", "hidden");
912
- this.canvas = this.canvasHolder.append("canvas").style("display", "block").style("position", "absolute").attr("data-testid", "sjpp-hic-detail-canvas").attr("width", blockwidth).attr("height", blockwidth).on("mousedown", (event) => {
913
- const body = select_default(document.body);
914
- const x = event.clientX;
915
- const y = event.clientY;
916
- const oldx = Number.parseInt(this.canvas.style("left"));
917
- const oldy = Number.parseInt(this.canvas.style("top"));
918
- body.on("mousemove", (event2) => {
919
- const xoff = event2.clientX - x;
920
- const yoff = event2.clientY - y;
921
- this.xBlock.block.panning(xoff);
922
- this.yBlock.block.panning(yoff);
923
- this.canvas.style("left", `${oldx + xoff}px`).style("top", `${oldy + yoff}px`);
924
- });
925
- body.on("mouseup", (event2) => {
926
- body.on("mousemove", null).on("mouseup", null);
927
- const xoff = event2.clientX - x;
928
- const yoff = event2.clientY - y;
929
- this.xBlock.block.pannedby(xoff);
930
- this.yBlock.block.pannedby(yoff);
931
- });
932
- });
933
- }
934
- async render() {
935
- this.calcResolution = this.parent("calcResolution");
936
- const state = this.parent("state");
937
- this.xBlock = new DetailBlock(
938
- this.app,
939
- this.hic,
940
- state.settings.widthHeightPx,
941
- this.bbmargin,
942
- this.plotDiv.xAxis,
943
- false
944
- );
945
- this.yBlock = new DetailBlock(this.app, this.hic, state.settings.widthHeightPx, this.bbmargin, this.rotor, true);
946
- this.renderCanvas(state.settings.widthHeightPx);
947
- await this.xBlock.loadBlock(state.x, this.canvasHolder, this.canvas);
948
- await this.yBlock.loadBlock(state.y, this.canvasHolder, this.canvas, this.sheath);
949
- this.update(this.data);
950
- }
951
- async update(data) {
952
- if (data.items.length == 0) {
953
- this.app.dispatch({ type: "loading_active", active: false });
954
- return;
955
- }
956
- this.data = data;
957
- const state = this.parent("state");
958
- const initialWidth = Number.parseInt(this.canvas.attr("width"));
959
- const holderChange = Number.parseInt(this.canvasHolder.style("width")) - initialWidth + state.settings.widthHeightPx;
960
- this.canvasHolder.style("width", `${holderChange}px`).style("height", `${holderChange}px`);
961
- this.canvas.attr("width", `${state.settings.widthHeightPx}px`).attr("height", `${state.settings.widthHeightPx}px`);
962
- if (this.xBlock.block.width != state.settings.widthHeightPx) {
963
- this.xBlock.block.width = state.settings.widthHeightPx;
964
- this.yBlock.block.width = state.settings.widthHeightPx;
965
- this.xBlock.block.zoom2px(0, initialWidth);
966
- this.yBlock.block.zoom2px(0, initialWidth);
967
- }
968
- this.ctx = this.canvas.node().getContext("2d");
969
- const coords = this.coordinates.getCoordinates(
970
- state.x,
971
- state.y,
972
- this.parent("data"),
973
- this.parent("calcResolution"),
974
- state.settings.widthHeightPx,
975
- this.parent("fragData")
976
- );
977
- this.coords = coords;
978
- this.ctx.clearRect(0, 0, state.settings.widthHeightPx, state.settings.widthHeightPx);
979
- for (const [xCoord, yCoord, width, height, value] of this.coords) {
980
- this.colorizeElement.colorizeElement(
981
- xCoord,
982
- yCoord,
983
- value,
984
- this.ctx,
985
- width,
986
- height,
987
- this.parent("min"),
988
- this.parent("max"),
989
- "detail"
990
- );
991
- }
992
- this.app.dispatch({ type: "loading_active", active: false });
993
- }
994
- };
995
-
996
- // tracks/hic/axes/Chromosome.ts
997
- var Chromosome = class {
998
- constructor(chr, width) {
999
- this.label = chr;
1000
- this.width = width;
1001
- }
1002
- };
1003
-
1004
- // tracks/hic/grid/Grid.ts
1005
- var Grid = class _Grid {
1006
- constructor(chrlst, resolution, chrlookup, binpx) {
1007
- this.chromosomeMatrix = /* @__PURE__ */ new Map();
1008
- this.chromosomeList = [];
1009
- this.xoff = 0;
1010
- this.yoff = 0;
1011
- this.chr2px = [];
1012
- this.chrlst = chrlst;
1013
- let totalpx = this.chrlst.length;
1014
- for (const chr of this.chrlst) {
1015
- const w = Math.ceil(chrlookup[chr.toUpperCase()].len / resolution) * binpx;
1016
- const chromosome = new Chromosome(chr, w);
1017
- this.chromosomeList.push(chromosome);
1018
- this.chr2px[chr] = w;
1019
- totalpx += w;
1020
- }
1021
- this.totalpx = totalpx;
1022
- for (let i = 0; i < this.chrlst.length; i++) {
1023
- const chrx = this.chrlst[i];
1024
- this.chromosomeMatrix.set(chrx, /* @__PURE__ */ new Map());
1025
- let yoff = 0;
1026
- for (let j = 0; j <= i; j++) {
1027
- const chry = this.chrlst[j];
1028
- const chrxChrLen = chrlookup[chrx.toUpperCase()].len;
1029
- const chryChrLen = chrlookup[chry.toUpperCase()].len;
1030
- const xbins = Math.ceil(chrxChrLen / resolution) * binpx;
1031
- const ybins = Math.ceil(chryChrLen / resolution) * binpx;
1032
- this.chromosomeMatrix.get(chrx).set(chry, {
1033
- x: this.xoff,
1034
- y: yoff,
1035
- xbins,
1036
- ybins,
1037
- data: []
1038
- //Empty array of data to fill later
1039
- });
1040
- yoff += this.chr2px[chry] + _Grid.borderWidth;
1041
- }
1042
- this.yoff = yoff;
1043
- this.xoff += this.chr2px[chrx] + _Grid.borderWidth;
1044
- }
1045
- }
1046
- static {
1047
- this.checkerFill = "#DEF3FA";
1048
- }
1049
- static {
1050
- this.spaceColor = "#CCC";
1051
- }
1052
- static {
1053
- this.fontSize = 15;
1054
- }
1055
- static {
1056
- this.font = font;
1057
- }
1058
- static {
1059
- this.borderWidth = 1;
1060
- }
1061
- static {
1062
- this.defaultChrLabWidth = 100;
1063
- }
1064
- };
1065
-
1066
- // tracks/hic/viewmodel/GridViewModel.ts
1067
- var GridViewModel = class {
1068
- constructor(opts) {
1069
- this.grid = new Grid(opts.hic.chrlst, opts.resolution || opts.hic.bpresolution[0], opts.hic.genome.chrlookup, 1);
1070
- }
1071
- };
1072
-
1073
- // tracks/hic/grid/GridRenderer.ts
1074
- var GridRenderer = class {
1075
- constructor(svg, layerMap, layerSv, grid) {
1076
- this.svg = svg;
1077
- this.layerMap = layerMap.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
1078
- this.layerSv = layerSv.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
1079
- this.grid = grid;
1080
- }
1081
- render() {
1082
- this.renderAxisX(this.grid);
1083
- this.renderAxisY(this.grid);
1084
- this.svg.attr("width", Grid.defaultChrLabWidth + this.grid.xoff).attr("height", Grid.fontSize + this.grid.yoff);
1085
- }
1086
- renderAxisX(grid) {
1087
- let xoff = 0;
1088
- this.grid.chromosomeList.forEach((chr, index) => {
1089
- const chrw = chr.width;
1090
- if (index % 2 === 0) {
1091
- this.layerMap.append("rect").attr("x", xoff).attr("width", chrw).attr("height", Grid.fontSize).attr("y", -Grid.fontSize).attr("fill", Grid.checkerFill);
1092
- }
1093
- this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-xAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "middle").attr("font-size", 12).attr("x", xoff + chrw / 2).text(chr.label);
1094
- xoff += chrw;
1095
- this.layerSv.append("line").attr("x1", xoff).attr("x2", xoff).attr("y2", grid.totalpx).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
1096
- xoff += Grid.borderWidth;
1097
- });
1098
- }
1099
- renderAxisY(grid) {
1100
- let yoff = 0;
1101
- this.grid.chromosomeList.forEach((chr, index) => {
1102
- const chrh = chr.width;
1103
- if (index % 2 === 0) {
1104
- this.layerMap.append("rect").attr("x", -Grid.defaultChrLabWidth).attr("width", Grid.defaultChrLabWidth).attr("height", chrh).attr("y", yoff).attr("fill", Grid.checkerFill);
1105
- }
1106
- this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-yAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "end").attr("dominant-baseline", "central").attr("font-size", 12).attr("y", yoff + chrh / 2).text(chr.label);
1107
- yoff += chrh;
1108
- this.layerSv.append("line").attr("x2", grid.totalpx).attr("y1", yoff).attr("y2", yoff).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
1109
- yoff += Grid.borderWidth;
1110
- });
1111
- }
1112
- };
1113
-
1114
- // tracks/hic/genome/ChrsTooltips.ts
1115
- var ChrsTooltips = class {
1116
- constructor() {
1117
- this.chrx_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1118
- this.chry_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1119
- }
1120
- render(img, chrx, chry) {
1121
- const p = img.node().getBoundingClientRect();
1122
- this.chrx_tip.clear().show(p.left, p.top).d.style("top", null).attr("data-testid", "sjpp-hic-chrx-tooltip").style("bottom", window.innerHeight - p.top - window.pageYOffset + "px").text(chrx);
1123
- this.chry_tip.clear().show(p.left, p.top).d.style("left", null).attr("data-testid", "sjpp-hic-chry-tooltip").style("right", document.body.clientWidth - p.left - window.pageXOffset + "px").text(chry);
1124
- }
1125
- };
1126
-
1127
- // tracks/hic/grid/GridElementRenderer.ts
1128
- var GridElementRenderer = class {
1129
- constructor(layerMap, app) {
1130
- this.app = app;
1131
- this.layerMap = layerMap;
1132
- this.tooltips = new ChrsTooltips();
1133
- }
1134
- render(obj, lead, follow, holder) {
1135
- obj.canvas = holder.append("canvas").style("display", "none").node();
1136
- obj.ctx = obj.canvas.getContext("2d");
1137
- obj.canvas.width = obj.xbins;
1138
- obj.canvas.height = obj.ybins;
1139
- obj.img = this.layerMap.append("image").attr("width", obj.canvas.width).attr("height", obj.canvas.height).attr("x", obj.x).attr("y", obj.y).on("click", async () => {
1140
- await this.app.dispatch({
1141
- type: "view_create",
1142
- view: "chrpair",
1143
- config: {
1144
- x: {
1145
- chr: lead
1146
- },
1147
- y: {
1148
- chr: follow
1149
- }
1150
- }
1151
- });
1152
- }).on("mouseover", () => {
1153
- this.tooltips.render(obj.img, lead, follow);
1154
- });
1155
- if (lead != follow) {
1156
- obj.canvas2 = holder.append("canvas").style("display", "none").node();
1157
- obj.canvas2.width = obj.ybins;
1158
- obj.canvas2.height = obj.xbins;
1159
- obj.ctx2 = obj.canvas2.getContext("2d");
1160
- obj.img2 = this.layerMap.append("image").attr("width", obj.canvas2.width).attr("height", obj.canvas2.height).attr("x", obj.y).attr("y", obj.x).on("click", async () => {
1161
- await this.app.dispatch({
1162
- type: "view_create",
1163
- view: "chrpair",
1164
- config: {
1165
- x: {
1166
- chr: follow
1167
- },
1168
- y: {
1169
- chr: lead
1170
- }
1171
- }
1172
- });
1173
- }).on("mouseover", () => {
1174
- this.tooltips.render(obj.img2, follow, lead);
1175
- });
1176
- } else {
1177
- obj.ctx2 = obj.ctx;
1178
- }
1179
- }
1180
- };
1181
-
1182
- // tracks/hic/grid/GridElementsRenderer.ts
1183
- var GridElementsRenderer = class {
1184
- constructor(grid, layerMap, app) {
1185
- this.grid = grid;
1186
- this.gridElementRenderer = new GridElementRenderer(layerMap, app);
1187
- }
1188
- render(holder) {
1189
- for (const [chrx, chryMap] of this.grid.chromosomeMatrix) {
1190
- for (const [chry, gridElem] of chryMap) {
1191
- this.gridElementRenderer.render(gridElem, chrx, chry, holder);
1192
- }
1193
- }
1194
- }
1195
- };
1196
-
1197
- // tracks/hic/genome/GenomeView.ts
1198
- var GenomeView = class {
1199
- constructor(opts) {
1200
- /** Dom */
1201
- this.tip = new Menu();
1202
- this.pica_x = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1203
- this.pica_y = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1204
- /** Data */
1205
- /** px width for each chr */
1206
- this.chr2px = {};
1207
- this.lead2follow = /* @__PURE__ */ new Map();
1208
- this.values = [];
1209
- /** Defaults */
1210
- this.defaultChrLabWidth = 100;
1211
- this.borderwidth = 1;
1212
- this.default_maxVPerc = 5;
1213
- this.fontsize = 15;
1214
- this.xoff = 0;
1215
- this.yoff = 0;
1216
- this.binpx = 1;
1217
- this.atdev_chrnum = 8;
1218
- this.min = 0;
1219
- this.max = 0;
1220
- this.app = opts.app;
1221
- this.hic = opts.hic;
1222
- this.plotDiv = opts.plotDiv;
1223
- this.data = opts.data;
1224
- this.parent = opts.parent;
1225
- this.resolution = opts.resolution || opts.hic.bpresolution[0];
1226
- this.svg = this.plotDiv.plot.append("svg").attr("data-testid", "sjpp-hic-genome-svg");
1227
- this.layer_map = this.svg.append("g").attr("data-testid", "sjpp-hic-layerMap-g");
1228
- this.layer_sv = this.svg.append("g").attr("data-testid", "sjpp-hic-layerSv-g");
1229
- this.colorizeElement = new ColorizeElement();
1230
- this.viewModel = new GridViewModel(opts);
1231
- this.viewRender = new GridRenderer(this.svg, this.layer_map, this.layer_sv, this.viewModel.grid);
1232
- this.gridElementsRenderer = new GridElementsRenderer(this.viewModel.grid, this.layer_map, this.app);
1233
- this.gridFormattedData = new GridElementsFormattedData();
1234
- }
1235
- makeSv() {
1236
- const unknownchr = /* @__PURE__ */ new Set();
1237
- const radius = 8;
1238
- for (const item of this.hic.sv.items) {
1239
- const _o = this.lead2follow.get(item.chr1);
1240
- if (!_o) {
1241
- unknownchr.add(item.chr1);
1242
- continue;
1243
- }
1244
- const obj = _o.get(item.chr2);
1245
- if (!obj) {
1246
- unknownchr.add(item.chr2);
1247
- continue;
1248
- }
1249
- const p1 = item.position1 / this.resolution;
1250
- const p2 = item.position2 / this.resolution;
1251
- this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cx", obj.x + p1).attr("cy", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
1252
- this.tooltipSv(event, item);
1253
- }).on("mouseout", () => {
1254
- this.tip.hide();
1255
- }).on("click", () => {
1256
- this.clickSv(item);
1257
- });
1258
- if (obj.img2) {
1259
- this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle-2").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cy", obj.x + p1).attr("cx", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
1260
- this.tooltipSv(event, item);
1261
- }).on("mouseout", () => {
1262
- this.tip.hide();
1263
- }).on("click", () => {
1264
- this.clickSv(item);
1265
- });
1266
- }
1267
- }
1268
- }
1269
- tooltipSv(event, item) {
1270
- this.tip.clear().show(event.clientX, event.clientY).d.append("div").text(
1271
- item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`
1272
- );
1273
- }
1274
- clickSv(item) {
1275
- const default_svpointspan = 5e5;
1276
- const default_subpanelpxwidth = 600;
1277
- const subpanel_bordercolor = "rgba(200,0,0,.1)";
1278
- const pane = newpane({ x: 100, y: 100 });
1279
- pane.header.text(
1280
- this.hic.name + " " + (item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`)
1281
- );
1282
- const tracks = [
1283
- {
1284
- type: tkt.hicstraw,
1285
- file: this.hic.file,
1286
- enzyme: this.hic.enzyme,
1287
- maxpercentage: this.default_maxVPerc,
1288
- pyramidup: 1,
1289
- name: this.hic.name
1290
- }
1291
- ];
1292
- if (this.hic.tklst) {
1293
- for (const t of this.hic.tklst) {
1294
- tracks.push(t);
1295
- }
1296
- }
1297
- first_genetrack_tolist(this.hic.genome, tracks);
1298
- const arg = {
1299
- holder: pane.body,
1300
- hostURL: this.hic.hostURL,
1301
- jwt: this.hic.jwt,
1302
- genome: this.hic.genome,
1303
- nobox: 1,
1304
- tklst: tracks
1305
- };
1306
- if (item.chr1 == item.chr2 && Math.abs(item.position2 - item.position1) < default_svpointspan * 2) {
1307
- arg.chr = item.chr1;
1308
- const w = Math.abs(item.position2 - item.position1);
1309
- arg.start = Math.max(1, Math.min(item.position1, item.position2) - w);
1310
- arg.stop = Math.min(
1311
- this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
1312
- Math.max(item.position1, item.position2) + w
1313
- );
1314
- } else {
1315
- arg.chr = item.chr1;
1316
- arg.start = Math.max(1, item.position1 - default_svpointspan / 2);
1317
- arg.stop = Math.min(
1318
- this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
1319
- item.position1 + default_svpointspan / 2
1320
- );
1321
- arg.width = default_subpanelpxwidth;
1322
- arg.subpanels = [
1323
- {
1324
- chr: item.chr2,
1325
- start: Math.max(1, item.position2 - default_svpointspan / 2),
1326
- stop: Math.min(
1327
- this.hic.genome.chrlookup[item.chr2.toUpperCase()].len,
1328
- item.position2 + default_svpointspan / 2
1329
- ),
1330
- width: default_subpanelpxwidth,
1331
- leftpad: 10,
1332
- leftborder: subpanel_bordercolor
1333
- }
1334
- ];
1335
- }
1336
- blocklazyload(arg);
1337
- }
1338
- render() {
1339
- this.viewRender.render();
1340
- this.gridElementsRenderer.render(this.hic.holder);
1341
- if (this.hic.sv && this.hic.sv.items) {
1342
- this.makeSv();
1343
- }
1344
- this.update(this.data);
1345
- }
1346
- update(data) {
1347
- this.data = data;
1348
- this.min = this.parent("min");
1349
- this.max = this.parent("max");
1350
- for (const data2 of this.data) {
1351
- if (!this.hic.chrlst.includes(data2.lead) || !this.hic.chrlst.includes(data2.follow)) continue;
1352
- const obj = this.viewModel.grid.chromosomeMatrix.get(data2.lead).get(data2.follow);
1353
- if (!obj) continue;
1354
- obj.ctx.clearRect(0, 0, obj.canvas.width, obj.canvas.height);
1355
- if (obj.canvas2) {
1356
- obj.ctx2.clearRect(0, 0, obj.canvas2.width, obj.canvas.height);
1357
- }
1358
- obj.data = this.gridFormattedData.formatData("genome", data2.items, this.binpx, this.resolution);
1359
- for (const [xPx, yPx, value] of obj.data) {
1360
- this.colorizeElement.colorizeElement(xPx, yPx, value, obj, this.binpx, this.binpx, this.min, this.max, "genome");
1361
- }
1362
- obj.img.attr("xlink:href", obj.canvas.toDataURL());
1363
- if (obj.canvas2) {
1364
- obj.img2.attr("xlink:href", obj.canvas2.toDataURL());
1365
- }
1366
- }
1367
- this.app.dispatch({ type: "loading_active", active: false });
1368
- }
1369
- };
1370
-
1371
- // tracks/hic/controls/NormalizationMethodControl.ts
1372
- var NormalizationMethodControl = class {
1373
- constructor(holder, normalization, defaultNmeth, callback) {
1374
- this.holder = holder;
1375
- this.normalization = normalization;
1376
- this.defaultNmeth = defaultNmeth;
1377
- this.callback = callback;
1378
- }
1379
- render() {
1380
- if (!this.normalization?.length) {
1381
- this.nmethSelect = this.holder.text(this.defaultNmeth);
1382
- } else {
1383
- this.nmethSelect = this.holder.attr("data-testid", "sjpp-hic-nmeth-select").style("margin-right", "10px").append("select").on("change", async () => {
1384
- const nmeth = this.nmethSelect.node().value;
1385
- this.callback(nmeth, "nmeth");
1386
- });
1387
- for (const n of this.normalization) {
1388
- this.nmethSelect.append("option").text(n);
1389
- }
1390
- }
1391
- }
1392
- update(option) {
1393
- const options = this.nmethSelect.node().options;
1394
- if (!options) return;
1395
- const selectedNmeth = Array.from(options).find((o) => o.value === option);
1396
- if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
1397
- selectedNmeth.selected = true;
1398
- }
1399
- };
1400
-
1401
- // tracks/hic/controls/CutoffControl.ts
1402
- var CutoffControl = class {
1403
- constructor(holder, value, callback) {
1404
- this.holder = holder;
1405
- this.value = value;
1406
- this.callback = callback;
1407
- }
1408
- render(opts) {
1409
- const cutoffDiv = this.holder.attr("data-testid", "sjpp-hic-cutoff-control").style("margin-right", "10px").append("input").attr("type", "number").style("width", opts && "width" in opts ? opts.width : "80px").style("margin-left", "0px").attr("type", "number").property("value", this.value).on("keyup", async (event) => {
1410
- if (event.code != "Enter") return;
1411
- const v = event.target.value;
1412
- this.callback(v);
1413
- });
1414
- return cutoffDiv;
1415
- }
1416
- };
1417
-
1418
- // tracks/hic/controls/MatrixTypeControl.ts
1419
- var MatrixTypeControl = class {
1420
- constructor(holder, callback) {
1421
- this.values = [
1422
- { label: "Observed", value: "observed" },
1423
- { label: "Expected", value: "expected" },
1424
- { label: "Observed/Expected", value: "oe" },
1425
- { label: "Log(Observed/Expected)", value: "log(oe)" }
1426
- // TODO: add server side logic to support these options
1427
- // { label: 'Log(Observed + 1)', value: 'log(obs+1)'},
1428
- // { label: 'Observed Pearson', value: 'op'}
1429
- ];
1430
- this.holder = holder;
1431
- this.callback = callback;
1432
- }
1433
- render() {
1434
- this.matrixSelect = this.holder.attr("data-testid", "sjpp-hic-matrix-type-select").style("margin-right", "10px").append("select").on("change", async () => {
1435
- this.callback(this.matrixSelect.node().value, "matrixType");
1436
- });
1437
- for (const matrixType of this.values) {
1438
- this.matrixSelect.append("option").text(matrixType.label).attr("value", matrixType.value);
1439
- }
1440
- }
1441
- update(option) {
1442
- const options = this.matrixSelect.node().options;
1443
- if (!options) return;
1444
- const selectedNmeth = Array.from(options).find((o) => o.value === option);
1445
- if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
1446
- selectedNmeth.selected = true;
1447
- }
1448
- };
1449
-
1450
- // tracks/hic/controls/ControlPanel.ts
1451
- var ControlPanel = class _ControlPanel {
1452
- constructor(opts) {
1453
- this.zoomBlockCallback = (bool) => {
1454
- const detailView = this.parent("detail");
1455
- detailView.xBlock.block.zoomblock(2, bool);
1456
- detailView.yBlock.block.zoomblock(2, bool);
1457
- };
1458
- this.minCallback = (v) => {
1459
- if (Number(v) > Number(this.parent("max"))) {
1460
- this.error("Min cutoff cannot be greater than max cutoff");
1461
- } else {
1462
- this.parent("min", Number(v));
1463
- this.reColorHeatmap();
1464
- this.parent("infoBar").update();
1465
- }
1466
- };
1467
- this.maxCallback = (v) => {
1468
- if (Number(v) < Number(this.parent("min"))) {
1469
- this.error(`Max cutoff cannot be less than min cutoff`);
1470
- } else if (Number(v) < 0) {
1471
- this.error(`Max cutoff cannot be less than 0`);
1472
- } else {
1473
- this.parent("max", Number(v));
1474
- this.reColorHeatmap();
1475
- this.parent("infoBar").update();
1476
- }
1477
- };
1478
- this.reColorHeatmap = () => {
1479
- if (this.parent("activeView") == "genome") {
1480
- const genomeView = this.parent("genome");
1481
- const chrMatrix = genomeView.viewRender.grid.chromosomeMatrix;
1482
- if (!chrMatrix) return;
1483
- for (const map of chrMatrix) {
1484
- const yMap = map[1];
1485
- for (const obj of yMap) {
1486
- const canvasObj = obj[1];
1487
- if (!canvasObj) continue;
1488
- for (const [leadpx, followpx, val] of canvasObj.data) {
1489
- this.colorizeElement.colorizeElement(
1490
- leadpx,
1491
- followpx,
1492
- val,
1493
- canvasObj,
1494
- 1,
1495
- 1,
1496
- this.parent("min"),
1497
- this.parent("max"),
1498
- "genome"
1499
- );
1500
- }
1501
- canvasObj.img.attr("xlink:href", canvasObj.canvas.toDataURL());
1502
- if (canvasObj.canvas2) {
1503
- canvasObj.img2.attr("xlink:href", canvasObj.canvas2.toDataURL());
1504
- }
1505
- }
1506
- }
1507
- } else if (this.parent("activeView") == "chrpair") {
1508
- const view = this.parent("chrpair");
1509
- for (const [xCoord, yCoord, val] of view.data) {
1510
- this.colorizeElement.colorizeElement(
1511
- xCoord,
1512
- yCoord,
1513
- val,
1514
- view.ctx,
1515
- view.binpx,
1516
- view.binpx,
1517
- this.parent("min"),
1518
- this.parent("max"),
1519
- "chrpair"
1520
- );
1521
- }
1522
- } else if (this.parent("activeView") == "detail") {
1523
- const view = this.parent("detail");
1524
- for (const [xCoord, yCoord, width, height, value] of view.coords) {
1525
- this.colorizeElement.colorizeElement(
1526
- xCoord,
1527
- yCoord,
1528
- value,
1529
- view.ctx,
1530
- width,
1531
- height,
1532
- this.parent("min"),
1533
- this.parent("max"),
1534
- "detail"
1535
- );
1536
- }
1537
- }
1538
- };
1539
- this.dropdownCallback = (v, prop) => {
1540
- const state = this.app.getState();
1541
- this.app.dispatch({
1542
- type: "view_update",
1543
- view: state.currView,
1544
- config: { [prop]: v }
1545
- });
1546
- };
1547
- this.type = _ControlPanel.type;
1548
- this.controls = {};
1549
- this.app = opts.app;
1550
- this.controlsDiv = opts.controlsDiv;
1551
- this.hic = opts.hic;
1552
- this.colorizeElement = new ColorizeElement();
1553
- this.parent = opts.parent;
1554
- this.error = opts.error;
1555
- }
1556
- static {
1557
- this.type = "controlPanel";
1558
- }
1559
- getState(appState) {
1560
- return appState;
1561
- }
1562
- addLabel(tr, text) {
1563
- return tr.append("td").style("color", "#858585").style("font-size", ".8em").style("vertical-align", text.toUpperCase() == "VIEW" ? "top" : "middle").text(text.toUpperCase());
1564
- }
1565
- init() {
1566
- const state = this.app.getState();
1567
- const menuWrapper = this.controlsDiv.attr("data-testid", "sjpp-hic-control-panel").style("background", "rgb(253, 250, 244)").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc");
1568
- let menuVisible = true;
1569
- this.controlsDiv.append("button").attr("data-testid", "sjpp-hic-burger-btn").style("display", "block").style("border", "none").style("font-size", "1.5em").style("background", "none").html("&#8801;").on("click", () => {
1570
- menuVisible = !menuVisible;
1571
- menu.style("display", menuVisible ? "block" : "none");
1572
- });
1573
- const menu = menuWrapper.append("div").attr("class", "sjpp-hic-menu").attr("data-testid", "sjpp-hic-menu").style("display", menuVisible ? "block" : "none");
1574
- const menuTable = menu.append("table").style("border-spacing", "3px");
1575
- this.controls.normalizationRow = menuTable.append("tr");
1576
- this.addLabel(this.controls.normalizationRow, "NORMALIZATION");
1577
- this.controls.nmeth = new NormalizationMethodControl(
1578
- this.controls.normalizationRow.append("td").attr("class", "sjpp-nmeth-select"),
1579
- this.hic.normalization,
1580
- state.defaultNmeth,
1581
- this.dropdownCallback
1582
- );
1583
- this.controls.nmeth.render();
1584
- this.controls.minCutoffRow = menuTable.append("tr");
1585
- this.controls.minCutoffLabel = this.addLabel(this.controls.minCutoffRow, "");
1586
- this.controls.inputBpMinV = new CutoffControl(
1587
- this.controls.minCutoffRow.append("td"),
1588
- this.parent("min"),
1589
- this.minCallback
1590
- ).render({ width: "120px" });
1591
- this.controls.maxCutoffRow = menuTable.append("tr");
1592
- this.controls.maxCutoffLabel = this.addLabel(this.controls.maxCutoffRow, "");
1593
- this.controls.inputBpMaxV = new CutoffControl(
1594
- this.controls.maxCutoffRow.append("td"),
1595
- this.parent("max"),
1596
- this.maxCallback
1597
- ).render({ width: "120px" });
1598
- this.controls.matrixTypeRow = menuTable.append("tr");
1599
- this.addLabel(this.controls.matrixTypeRow, "matrix type");
1600
- this.controls.matrixType = new MatrixTypeControl(this.controls.matrixTypeRow.append("td"), this.dropdownCallback);
1601
- this.controls.matrixType.render();
1602
- this.controls.widthRow = menuTable.append("tr");
1603
- this.addLabel(this.controls.widthRow, "WIDTH / height");
1604
- this.controls.width = this.controls.widthRow.append("td");
1605
- this.controls.width.attr("data-testid", "sjpp-hic-block-size-input").style("margin-right", "10px").append("input").attr("type", "number").style("width", "80px").style("margin-left", "0px").attr("type", "number").property("value", state.width).on("keyup", async (event) => {
1606
- if (event.code != "Enter") return;
1607
- const v = event.target.value;
1608
- this.app.dispatch({
1609
- type: "view_update",
1610
- config: {
1611
- settings: { widthHeightPx: Number.parseInt(v) }
1612
- }
1613
- });
1614
- });
1615
- const viewRow = menuTable.append("tr");
1616
- this.addLabel(viewRow, "VIEW");
1617
- const viewBtnDiv = viewRow.append("td");
1618
- this.controls.view = viewBtnDiv.append("span").attr("data-testid", "sjpp-hic-view-span").style("padding-right", "5px").style("display", "block");
1619
- this.controls.genomeViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-genome-view-btn").style("display", "none").style("padding", "2px").style("margin-top", "4px").html("&#8810; Genome").on("click", async () => {
1620
- await this.app.dispatch({
1621
- type: "view_create",
1622
- view: "genome",
1623
- config: {
1624
- x: {},
1625
- y: {}
1626
- }
1627
- });
1628
- });
1629
- this.controls.chrpairViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-chrpair-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").on("click", async () => {
1630
- const currState = this.app.getState();
1631
- await this.app.dispatch({
1632
- type: "view_create",
1633
- view: "chrpair",
1634
- config: {
1635
- x: {
1636
- chr: currState.x.chr
1637
- },
1638
- y: {
1639
- chr: currState.y.chr
1640
- }
1641
- }
1642
- });
1643
- });
1644
- this.controls.horizontalViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-horizontal-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("Horizontal View &#8811;").on("click", async () => {
1645
- await this.app.dispatch({
1646
- type: "view_create",
1647
- view: "horizontal"
1648
- });
1649
- });
1650
- this.controls.detailViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-detail-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("&#8810; Detailed View").on("click", async () => {
1651
- await this.app.dispatch({
1652
- type: "view_create",
1653
- view: "detail"
1654
- });
1655
- });
1656
- this.controls.zoomDiv = menuTable.append("tr").attr("data-testid", "sjpp-hic-zoom-div").style("display", state.currView == "detail" ? "contents" : "none");
1657
- this.addLabel(this.controls.zoomDiv, "ZOOM");
1658
- const zoomDiv = this.controls.zoomDiv.append("td");
1659
- this.controls.zoomIn = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-in-btn").style("margin-right", "10px").text("In").on("click", () => {
1660
- this.zoomBlockCallback(false);
1661
- });
1662
- this.controls.zoomOut = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-out-btn").style("margin-right", "10px").text("Out").on("click", () => {
1663
- this.zoomBlockCallback(true);
1664
- });
1665
- }
1666
- showBtns() {
1667
- const state = this.app.getState();
1668
- this.controls.genomeViewBtn.style("display", state.currView === "genome" ? "none" : "inline-block");
1669
- if (state.currView === "detail") {
1670
- this.controls.chrpairViewBtn.html(`&#8810; Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
1671
- this.controls.horizontalViewBtn.style("display", "block");
1672
- this.controls.zoomDiv.style("display", "contents");
1673
- this.controls.detailViewBtn.style("display", "none");
1674
- } else if (state.currView === "horizontal") {
1675
- this.controls.chrpairViewBtn.html(`&#8810; Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
1676
- this.controls.detailViewBtn.style("display", "block");
1677
- this.controls.horizontalViewBtn.style("display", "none");
1678
- this.controls.zoomDiv.style("display", "none");
1679
- } else {
1680
- this.controls.chrpairViewBtn.style("display", "none");
1681
- this.controls.horizontalViewBtn.style("display", "none");
1682
- this.controls.detailViewBtn.style("display", "none");
1683
- this.controls.zoomDiv.style("display", "none");
1684
- this.controls.widthRow.style("display", "none");
1685
- }
1686
- }
1687
- showHideControls() {
1688
- const state = this.app.getState();
1689
- this.controls.normalizationRow.style("display", state.currView == "horizontal" ? "none" : "");
1690
- this.controls.minCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
1691
- this.controls.maxCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
1692
- this.controls.matrixTypeRow.style("display", state.currView == "horizontal" ? "none" : "");
1693
- this.controls.widthRow.style("display", state.currView == "detail" ? "contents" : "none");
1694
- }
1695
- main(appState) {
1696
- const state = this.app.getState(appState);
1697
- this.controls.nmeth.update(state[state.currView].nmeth);
1698
- this.controls.matrixType.update(state[state.currView].matrixType);
1699
- this.controls.zoomDiv.style("display", state.currView == "detail" ? "contents" : "none");
1700
- if (state.currView == "chrpair") {
1701
- this.controls.view.text(`${state.x.chr}-${state.y.chr} Pair`);
1702
- } else {
1703
- this.controls.view.text(state.currView.charAt(0).toUpperCase() + state.currView.slice(1));
1704
- }
1705
- const formatAbsMin = this.parent("absMin") < 1e-5 ? Number(this.parent("absMin")).toExponential(1) : Number(this.parent("absMin").toFixed(6));
1706
- const formatAbsMax = this.parent("absMax") < 1e-5 ? Number(this.parent("absMax")).toExponential(1) : Number(this.parent("absMax").toFixed(6));
1707
- this.controls.width.select("input").property("value", state.settings.widthHeightPx);
1708
- this.controls.inputBpMinV.property("value", this.parent("min"));
1709
- this.controls.inputBpMaxV.property("value", this.parent("max"));
1710
- this.controls.minCutoffLabel.html(`MIN CUTOFF <br>(>= ${formatAbsMin})`);
1711
- this.controls.maxCutoffLabel.html(`MAX CUTOFF <br>(<= ${formatAbsMax})`);
1712
- this.showBtns();
1713
- this.showHideControls();
1714
- }
1715
- };
1716
- var controlPanelInit = getCompInit(ControlPanel);
1717
-
1718
- // tracks/hic/dom/InfoBar.ts
1719
- var InfoBar = class {
1720
- constructor(opts) {
1721
- /** Defaults **/
1722
- //Color shown on the left of the color scale
1723
- this.startColor = "white";
1724
- //Color shown on the right of the color scale
1725
- this.endColor = "red";
1726
- this.addLabel = (text) => {
1727
- return this.labelRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toLowerCase().replace(/\s/g, "-")}-label`).style("color", "#858585").style("font-size", ".8em").style("text-align", "center").style("vertical-align", "middle").text(text.toUpperCase());
1728
- };
1729
- this.addValue = (text) => {
1730
- return this.valueRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toString().toLowerCase().replace(/\s/g, "-")}-value`).style("font-size", "1em").style("text-align", "center").style("vertical-align", "middle").text(text);
1731
- };
1732
- this.type = "infoBar";
1733
- this.app = opts.app;
1734
- this.hic = opts.hic;
1735
- const table = opts.infoBarDiv;
1736
- this.labelRow = table.append("tr");
1737
- this.valueRow = table.append("tr");
1738
- this.parent = opts.parent;
1739
- }
1740
- async render() {
1741
- this.addLabel("Version");
1742
- this.addValue(this.hic.version);
1743
- this.addLabel("Enzyme");
1744
- this.addValue(this.hic.enzyme || "N/A");
1745
- this.addLabel("Resolution");
1746
- this.resolutionDiv = this.addValue("");
1747
- this.colorScaleLabel = this.addLabel("Scale");
1748
- this.colorScaleDiv = this.valueRow.append("td").attr("data-testid", "sjpp-hic-color-scale");
1749
- const min = this.parent("min");
1750
- let max = this.parent("max");
1751
- if (min == max) max = max + 0.01;
1752
- this.colorScale = new ColorScale({
1753
- barheight: 20,
1754
- barwidth: 100,
1755
- domain: [min, max],
1756
- fontSize: 12,
1757
- height: 40,
1758
- width: 150,
1759
- holder: this.colorScaleDiv,
1760
- colors: [this.startColor, this.endColor],
1761
- position: "20,0",
1762
- ticks: 3,
1763
- tickSize: 5,
1764
- //Do not use min value here on initialization. It's 0 and will not update later.
1765
- markedValue: 1
1766
- });
1767
- }
1768
- update() {
1769
- const res = this.parent("calcResolution");
1770
- let resolutionText;
1771
- if (res < this.hic.bpresolution[this.hic.bpresolution.length - 1]) {
1772
- resolutionText = `${res} fragment${res > 1 ? "s" : ""}`;
1773
- } else {
1774
- resolutionText = bplen(res);
1775
- }
1776
- this.resolutionDiv.text(resolutionText);
1777
- if (this.parent("state").currView == "horizontal") {
1778
- this.colorScaleLabel.style("display", "none");
1779
- this.colorScaleDiv.style("display", "none");
1780
- } else {
1781
- this.colorScaleLabel.style("display", "");
1782
- this.colorScaleDiv.style("display", "");
1783
- const min = this.parent("min");
1784
- const max = this.parent("max");
1785
- if (min < 0) {
1786
- this.colorScale.colors = ["blue", "white", "red"];
1787
- this.colorScale.domain = [min, 0, max];
1788
- } else {
1789
- this.colorScale.colors = ["white", "red"];
1790
- this.colorScale.domain = [0, max];
1791
- }
1792
- this.colorScale.markedValue = min;
1793
- this.colorScale.updateScale();
1794
- }
1795
- }
1796
- };
1797
-
1798
- // tracks/hic/data/DataMapper.ts
1799
- var DataMapper = class {
1800
- constructor(hic, percentile) {
1801
- this.hic = hic;
1802
- this.percentile = percentile ? percentile / 100 : 0.99;
1803
- }
1804
- sortData(data) {
1805
- const vlst = [];
1806
- if (data?.items && data?.items.length) {
1807
- for (const i of data.items) {
1808
- vlst.push(i[2]);
1809
- }
1810
- } else {
1811
- const blankChrs = /* @__PURE__ */ new Set();
1812
- for (const d of data) {
1813
- if (d.lead == "chrM" && !d.items.length || d.lead == "chrY" && !d.items.length) {
1814
- blankChrs.add(d.lead);
1815
- continue;
1816
- }
1817
- for (const i of d.items) {
1818
- vlst.push(i[2]);
1819
- }
1820
- }
1821
- if (blankChrs.size) {
1822
- for (const c of blankChrs) {
1823
- const idx = this.hic.chrlst.indexOf(c);
1824
- this.hic.chrlst.splice(idx, 1);
1825
- }
1826
- }
1827
- }
1828
- const sortedVlst = vlst.sort((a, b) => a - b);
1829
- const max = sortedVlst[Math.floor(sortedVlst.length * this.percentile)];
1830
- const min = sortedVlst[0];
1831
- return [min, max, sortedVlst[sortedVlst.length - 1]];
1832
- }
1833
- };
1834
-
1835
- // tracks/hic/data/GenomeDataFetcher.ts
1836
- var GenomeDataFetcher = class {
1837
- constructor(hic, debugmode, errList = []) {
1838
- this.data = [];
1839
- this.hic = hic;
1840
- this.debugmode = debugmode;
1841
- this.errList = errList || [];
1842
- }
1843
- async getData(obj) {
1844
- if (this.data.length) this.data = [];
1845
- if (!obj?.matrixType) obj.matrixType = "observed";
1846
- try {
1847
- const res = await dofetch3("hicgenome?", {
1848
- method: "POST",
1849
- body: JSON.stringify({
1850
- chrlst: this.hic.chrlst,
1851
- nmeth: obj.nmeth,
1852
- resolution: obj.resolution,
1853
- matrixType: obj.matrixType,
1854
- file: this.hic.file,
1855
- url: this.hic.url,
1856
- nochr: this.hic.nochr
1857
- })
1858
- });
1859
- if (res.error) {
1860
- const errs = res.error.split("\n");
1861
- for (const e of errs) {
1862
- this.errList.push(e);
1863
- }
1864
- }
1865
- return res.data;
1866
- } catch (e) {
1867
- this.errList.push(e.message || e);
1868
- if (e.stack) console.error(e.stack);
1869
- }
1870
- }
1871
- };
1872
-
1873
- // tracks/hic/data/DataFetcher.ts
1874
- var DataFetcher = class {
1875
- constructor(hic, debugmode, errList = []) {
1876
- this.hic = hic;
1877
- this.debugmode = debugmode;
1878
- this.errList = errList || [];
1879
- }
1880
- async getData(obj) {
1881
- if (!obj?.matrixType) obj.matrixType = "observed";
1882
- const arg = {
1883
- matrixType: obj.matrixType,
1884
- file: this.hic.file,
1885
- url: this.hic.url,
1886
- pos1: this.hic.nochr ? obj.lead.replace("chr", "") : obj.lead,
1887
- pos2: this.hic.nochr ? obj.follow.replace("chr", "") : obj.follow,
1888
- nmeth: obj.nmeth,
1889
- resolution: obj.resolution
1890
- };
1891
- try {
1892
- const data = await dofetch3("hicdata?", {
1893
- method: "POST",
1894
- body: JSON.stringify(arg)
1895
- });
1896
- if (data.error) {
1897
- throw Error(`${obj.lead} - ${obj.follow}: ${data.error.error}`);
1898
- }
1899
- if (!data.items || data.items.length == 0) return;
1900
- return data;
1901
- } catch (e) {
1902
- this.errList.push(e.message || e);
1903
- if (e.stack) console.error(e.stack);
1904
- }
1905
- }
1906
- };
1907
-
1908
- // tracks/hic/HicComponent.ts
1909
- var HicComponent = class _HicComponent {
1910
- constructor(opts) {
1911
- this.genomeData = [];
1912
- this.calcResolution = null;
1913
- this.firstRender = true;
1914
- this.min = 0;
1915
- this.absMin = 0;
1916
- this.max = 0;
1917
- this.absMax = 0;
1918
- this.hasStatePreMain = true;
1919
- this.type = _HicComponent.type;
1920
- this.hic = opts.hic;
1921
- this.state = opts.state;
1922
- this.dom = opts.dom;
1923
- this.errList = opts.errList;
1924
- this.plotDiv = this.dom.plotDiv.append("table").classed("sjpp-hic-plot-main", true);
1925
- const tr1 = this.plotDiv.append("tr");
1926
- const tr2 = this.plotDiv.append("tr");
1927
- this.plotDiv = {
1928
- plot: tr1.append("td").classed("sjpp-hic-plot", true).attr("data-testid", "sjpp-hic-plot"),
1929
- yAxis: tr1.append("td").classed("sjpp-hic-plot-yaxis", true).attr("data-testid", "sjpp-hic-yaxis"),
1930
- xAxis: tr2.append("td").classed("sjpp-hic-plot-xaxis", true).attr("data-testid", "sjpp-hic-xaxis"),
1931
- blank: tr2.append("td")
1932
- };
1933
- this.app = opts.app;
1934
- this.dataMapper = new DataMapper(this.hic, opts.state.maxCutoffPercentile);
1935
- this.activeView = this.state.currView;
1936
- this.error = opts.error;
1937
- this.resolution = new Resolution(this.error);
1938
- this.parent = (prop) => {
1939
- return this[prop];
1940
- };
1941
- this.detailDataMapper = new DetailDataMapper(this.hic, this.errList, this.parent);
1942
- }
1943
- static {
1944
- this.type = "view";
1945
- }
1946
- getState(appState) {
1947
- return appState;
1948
- }
1949
- reactsTo(action) {
1950
- if (action.type.startsWith("view")) return true;
1951
- else return false;
1952
- }
1953
- initView() {
1954
- const opts = {
1955
- plotDiv: this.plotDiv,
1956
- hic: this.hic,
1957
- app: this.app,
1958
- parent: (prop) => {
1959
- return this[prop];
1960
- }
1961
- };
1962
- if (this.state.currView == "genome") {
1963
- opts["data"] = this.data;
1964
- this.genome = new GenomeView(opts);
1965
- this.genome.render();
1966
- } else if (this.state.currView === "chrpair") {
1967
- opts["items"] = this.data;
1968
- this.chrpair = new ChrPairView(opts);
1969
- this.chrpair.render();
1970
- } else if (this.state.currView === "detail") {
1971
- opts["data"] = this.data;
1972
- this.detail = new DetailView(opts);
1973
- this.detail.render();
1974
- } else if (this.state.currView === "horizontal") {
1975
- this.horizontal = new HorizontalView(opts);
1976
- this.horizontal.render();
1977
- } else {
1978
- throw Error(`Unknown view: ${this.state.currView}`);
1979
- }
1980
- }
1981
- async fetchData(obj) {
1982
- if (this.data?.length) this.data = [];
1983
- if (this.state.currView == "genome") {
1984
- if (this.activeView != "genome" && this.genomeData?.length) this.data = this.genomeData;
1985
- else {
1986
- const genomeFetcher = new GenomeDataFetcher(this.hic, true, this.errList);
1987
- this.genomeData = await genomeFetcher.getData(obj);
1988
- this.data = this.genomeData;
1989
- }
1990
- } else if (this.state.currView == "detail") {
1991
- this.data = await this.detailDataMapper.getData(this.state.x, this.state.y, this.fragData);
1992
- } else {
1993
- if (!this.state?.x?.chr || !this.state?.y?.chr) {
1994
- this.errList.push(`No positions provided for ${this.activeView} view.`);
1995
- return;
1996
- } else {
1997
- const chrx = this.state.x;
1998
- const chry = this.state.y;
1999
- obj["lead"] = `${chrx.start && chrx.stop ? `${chrx.chr}:${chrx.start}-${chrx.stop}` : chrx.chr}`;
2000
- obj["follow"] = `${chry.start && chry.stop ? `${chry.chr}:${chry.start}-${chry.stop}` : chry.chr}`;
2001
- }
2002
- const dataFetcher = new DataFetcher(this.hic, true, this.errList);
2003
- this.data = await dataFetcher.getData(obj);
2004
- }
2005
- }
2006
- async setResolution(appState) {
2007
- const state = this.app.getState(appState);
2008
- this.calcResolution = this.resolution.getResolution(state, this.hic);
2009
- if (state.currView == "detail" && this.calcResolution == null) {
2010
- await this.detailDataMapper.getFragData(state.x, state.y);
2011
- this.fragData = this.detailDataMapper.frag;
2012
- const maxFragSpan = Math.min(
2013
- this.fragData.x.stop - this.fragData.x.start,
2014
- this.fragData.y.stop - this.fragData.y.start
2015
- );
2016
- this.calcResolution = this.resolution.findResFromArray(
2017
- maxFragSpan,
2018
- state.minFragSpan,
2019
- this.hic.fragresolution,
2020
- true
2021
- );
2022
- } else {
2023
- this.fragData = null;
2024
- }
2025
- return this.calcResolution;
2026
- }
2027
- async setDataArgs(appState) {
2028
- const state = this.app.getState(appState);
2029
- const currView = state[state.currView];
2030
- const args = {
2031
- nmeth: currView.nmeth,
2032
- resolution: await this.setResolution(appState),
2033
- matrixType: currView.matrixType
2034
- };
2035
- if (state.currView == "chrpair") {
2036
- args["lead"] = state.x.chr;
2037
- args["follow"] = state.y.chr;
2038
- }
2039
- return args;
2040
- }
2041
- async getViewData(appState) {
2042
- const args = await this.setDataArgs(appState);
2043
- await this.fetchData(args);
2044
- if (this.data?.length > 0 || this.data?.items?.length > 0) {
2045
- const [min, max, absMax] = this.dataMapper.sortData(this.data);
2046
- this.min = this.absMin = min;
2047
- this.max = max;
2048
- this.absMax = absMax;
2049
- } else {
2050
- if (this.state.currView != "genome") {
2051
- const state = this.app.getState(appState);
2052
- const xPosMessage = state.x?.start ? `${state.x.chr}:${state.x.start}-${state.x.stop}` : state.x.chr;
2053
- const yPosMessage = state.y?.start ? `${state.y.chr}:${state.y.start}-${state.y.stop}` : state.y.chr;
2054
- this.errList.push(`No data returned for ${xPosMessage} and ${yPosMessage}`);
2055
- }
2056
- }
2057
- }
2058
- async init() {
2059
- this.components = {
2060
- controls: await controlPanelInit({
2061
- app: this.app,
2062
- controlsDiv: this.dom.controlsDiv,
2063
- hic: this.hic,
2064
- parent: (prop, value) => {
2065
- if (value) this[prop] = value;
2066
- return this[prop];
2067
- },
2068
- error: this.error.bind(this)
2069
- })
2070
- };
2071
- this.infoBar = new InfoBar({
2072
- app: this.app,
2073
- infoBarDiv: this.dom.infoBarDiv.append("table").style("border-spacing", "3px"),
2074
- hic: this.hic,
2075
- parent: (prop) => {
2076
- return this[prop];
2077
- }
2078
- });
2079
- this.infoBar.render();
2080
- }
2081
- async main(appState) {
2082
- if (this.errList.length) {
2083
- this.app.dispatch({ type: "loading_active", active: false });
2084
- return;
2085
- }
2086
- const state = this.app.getState(appState);
2087
- if (this.firstRender == true) {
2088
- this.firstRender = false;
2089
- await this.getViewData(appState);
2090
- this.initView();
2091
- } else {
2092
- if (state.currView != "horizontal") {
2093
- this.app.dispatch({ type: "loading_active", active: true });
2094
- await this.getViewData(appState);
2095
- }
2096
- if (this.activeView != state.currView) {
2097
- if (this.activeView == "genome") {
2098
- this.genome.svg.remove();
2099
- } else {
2100
- this.plotDiv.xAxis.selectAll("*").remove();
2101
- this.plotDiv.yAxis.selectAll("*").remove();
2102
- this.plotDiv.plot.selectAll("*").remove();
2103
- }
2104
- this.activeView = state.currView;
2105
- this.initView();
2106
- } else {
2107
- this[state.currView].update(this.data);
2108
- }
2109
- }
2110
- this.infoBar.update();
2111
- if (this.errList.length) {
2112
- this.error(this.errList);
2113
- this.app.dispatch({ type: "loading_active", active: false });
2114
- }
2115
- }
2116
- };
2117
- var viewCompInit = getCompInit(HicComponent);
2118
-
2119
- // tracks/hic/HicApp.ts
2120
- var HicApp = class _HicApp extends AppBase {
2121
- constructor(opts) {
2122
- super(opts);
2123
- this.views = ["genome", "chrpair", "detail", "horizontal"];
2124
- this.errList = [];
2125
- /** Required for rx but not in use */
2126
- this.wasDestroyed = false;
2127
- this.type = _HicApp.type;
2128
- this.hic = {
2129
- enzyme: opts.enzyme,
2130
- file: opts.file,
2131
- url: opts.url,
2132
- genome: opts.genome,
2133
- holder: opts.holder,
2134
- hostUrl: opts.hostUrl,
2135
- jwt: opts.jwt,
2136
- position1: opts.position1,
2137
- position2: opts.position2,
2138
- maxCutoffPercentile: opts.maxCutoffPercentile,
2139
- name: "name" in opts ? opts.name : "Hi-C",
2140
- tklist: "tklst" in opts ? opts.tklst : [],
2141
- state: "state" in opts ? opts.state : {}
2142
- };
2143
- this.dom = {
2144
- errorDiv: opts.holder.append("div").classed("sjpp-hic-error", true),
2145
- controlsDiv: opts.holder.append("div").classed("sjpp-hic-controls", true).style("display", "inline-block"),
2146
- infoBarDiv: opts.holder.append("div").classed("sjpp-hic-infobar", true).style("display", "inline-block").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc"),
2147
- loadingDiv: select_default("body").append("div").attr("id", "sjpp-loading-overlay"),
2148
- plotDiv: opts.holder.append("div").classed("sjpp-hic-main", true).style("display", "inline-block"),
2149
- tip: new Menu()
2150
- };
2151
- }
2152
- static {
2153
- this.type = "app";
2154
- }
2155
- async error(err) {
2156
- if (err && typeof err == "string") this.errList.push(err);
2157
- showErrorsWithCounter(this.errList, this.dom.errorDiv);
2158
- this.errList = [];
2159
- }
2160
- determineView() {
2161
- if (!this.hic.position1 && !this.hic.position2 && !this.hic.state.currView) this.hic.state.currView = "genome";
2162
- if (!this.hic.position1 && this.hic.position2) this.errList.push("Missing first position");
2163
- if (this.hic.position1 && !this.hic.position2) this.errList.push("Missing second position");
2164
- if (this.hic.position1 && this.hic.position2) {
2165
- const pos1 = this.hic.position1.split(/[:-]/);
2166
- const pos2 = this.hic.position2.split(/[:-]/);
2167
- this.hic.state.x = { chr: pos1[0] };
2168
- this.hic.state.y = { chr: pos2[0] };
2169
- if (!Number.isNaN(+pos1[1]) && !Number.isNaN(+pos1[2])) {
2170
- this.hic.state.x.start = +pos1[1];
2171
- this.hic.state.x.stop = +pos1[2];
2172
- this.hic.state.y.start = +pos2[1];
2173
- this.hic.state.y.stop = +pos2[2];
2174
- this.hic.state.currView = "detail";
2175
- } else {
2176
- this.hic.state.currView = "chrpair";
2177
- }
2178
- } else {
2179
- if (!this.views.some((v) => v === this.hic.state.currView)) this.error(`Unknown view: ${this.hic.state.currView}`);
2180
- else return this.hic.state.currView;
2181
- }
2182
- }
2183
- getViewsConfig() {
2184
- if (this.hic.maxCutoffPercentile) this.hic.state.maxCutoffPercentile = this.hic.maxCutoffPercentile;
2185
- let nmeth;
2186
- if (this.hic["normalization"]?.length > 0) {
2187
- if (!this.hic["normalization"].includes("NONE")) this.hic["normalization"].unshift("NONE");
2188
- nmeth = this.hic["normalization"][0];
2189
- } else {
2190
- nmeth = "NONE";
2191
- }
2192
- if (this.hic.state.currView) {
2193
- if (!this.hic.state[this.hic.state.currView]) this.hic.state[this.hic.state.currView] = {};
2194
- if (!this.hic.state[this.hic.state.currView]?.matrixType) {
2195
- this.hic.state[this.hic.state.currView].matrixType = "observed";
2196
- }
2197
- if (!this.hic.state[this.hic.state.currView]?.nmeth) {
2198
- this.hic.state[this.hic.state.currView].nmeth = nmeth;
2199
- }
2200
- }
2201
- for (const v of this.views) {
2202
- if (!this.hic.state[v]) {
2203
- this.hic.state[v] = {
2204
- matrixType: "observed",
2205
- nmeth
2206
- };
2207
- }
2208
- }
2209
- }
2210
- async init() {
2211
- this.determineView();
2212
- try {
2213
- await hicParseFile(this.hic, true, this.errList);
2214
- this.getViewsConfig();
2215
- this.store = await hicStoreInit({ app: this.api, state: this.hic.state });
2216
- this.state = await this.store.copyState();
2217
- this.components = {
2218
- loadingOverlay: await loadingInit({
2219
- app: this.api,
2220
- loadingDiv: this.dom.loadingDiv
2221
- }),
2222
- view: await viewCompInit({
2223
- app: this.api,
2224
- state: this.state,
2225
- dom: this.dom,
2226
- hic: this.hic,
2227
- errList: this.errList,
2228
- error: this.error
2229
- })
2230
- };
2231
- await this.api.dispatch();
2232
- } catch (e) {
2233
- console.error(e.stack || e);
2234
- }
2235
- }
2236
- main() {
2237
- if (this.errList.length) {
2238
- this.error(this.errList);
2239
- this.dom.loadingDiv.style("display", "none");
2240
- return;
2241
- }
2242
- }
2243
- };
2244
- var hicInit = getAppInit(HicApp);
2245
- export {
2246
- hicInit
2247
- };
2248
- //# sourceMappingURL=HicApp-XPZVZXB7.js.map