@sjcrh/proteinpaint-client 2.185.0 → 2.186.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/2dmaf-F5QNP7AQ.js +1371 -0
- package/dist/AIProjectAdmin-ROSQHK6Q.js +827 -0
- package/dist/AIProjectAdmin-ROSQHK6Q.js.map +7 -0
- package/dist/AppHeader-STVCDLET.js +833 -0
- package/dist/BoxPlot-CU7MEBH7.js +1217 -0
- package/dist/CorrelationVolcano-OE4R2GS3.js +617 -0
- package/dist/DE-SR7PJPKI.js +93 -0
- package/dist/DEinput-PRIAIBFH.js +299 -0
- package/dist/DEinput-PRIAIBFH.js.map +7 -0
- package/dist/DifferentialAnalysis-UWTYK7NU.js +241 -0
- package/dist/Disco-IL6REGSA.js +3235 -0
- package/dist/Disco.UI-JHHLS5BA.js +242 -0
- package/dist/DmrPlot-DDP53T3F.js +640 -0
- package/dist/GB-F4LMYMHF.js +1127 -0
- package/dist/GB-F4LMYMHF.js.map +7 -0
- package/dist/GeneExpInput-ZWBC226P.js +363 -0
- package/dist/GeneExpInput-ZWBC226P.js.map +7 -0
- package/dist/HicApp-RVFHTYED.js +2248 -0
- package/dist/NumBinaryEditor-B3FXQAOH.js +268 -0
- package/dist/NumBinaryEditor.unit.spec-75YQJ2U6.js +284 -0
- package/dist/NumContEditor-5PYW3OLY.js +105 -0
- package/dist/NumContEditor.unit.spec-F7ZRDGBN.js +167 -0
- package/dist/NumCustomBinEditor-TBT6GLYQ.js +36 -0
- package/dist/NumCustomBinEditor.unit.spec-6YHU45XV.js +282 -0
- package/dist/NumDiscreteEditor-N6OJYSJA.js +177 -0
- package/dist/NumDiscreteEditor.unit.spec-HQS5RZ6R.js +200 -0
- package/dist/NumRegularBinEditor-HSDDKVNG.js +36 -0
- package/dist/NumRegularBinEditor.unit.spec-33KN2MVM.js +225 -0
- package/dist/NumSplineEditor-XERKOACS.js +190 -0
- package/dist/NumSplineEditor.unit.spec-MPVM6KSC.js +197 -0
- package/dist/NumericDensity-35EKYW3V.js +36 -0
- package/dist/NumericDensity.unit.spec-OR24PPRJ.js +219 -0
- package/dist/NumericHandler-D6ZNGRE3.js +37 -0
- package/dist/NumericHandler.unit.spec-EKPGVSXI.js +217 -0
- package/dist/RunChart2-7DOXOFXV.js +756 -0
- package/dist/SC-APZRV4H6.js +826 -0
- package/dist/SC-APZRV4H6.js.map +7 -0
- package/dist/Volcano-X4ZWK644.js +1344 -0
- package/dist/Volcano-X4ZWK644.js.map +7 -0
- package/dist/WSIViewer-E247ELKN.js +47971 -0
- package/dist/WsiSamplesPlot-3522VRB5.js +163 -0
- package/dist/adSandbox-IDFY5P2P.js +36 -0
- package/dist/alphaGenome-F3W7GJQ5.js +173 -0
- package/dist/app-2HDSFMRM.js +47 -0
- package/dist/app-LIWPFL7C.js +35 -0
- package/dist/app.js +10 -10
- package/dist/bam-TBHHSATL.js +857 -0
- package/dist/barchart-HHFCBOZE.js +45 -0
- package/dist/barchart.events-UQUSSRXB.js +45 -0
- package/dist/barchart.integration.spec-OF3MWFQ5.js +1675 -0
- package/dist/barchart2-XRMPCBBU.js +309 -0
- package/dist/block-5UEORHFB.js +6200 -0
- package/dist/block.init-QSSFUVIT.js +36 -0
- package/dist/block.mds.expressionrank-VBIIJHQF.js +357 -0
- package/dist/block.mds.geneboxplot-KSBHXBNX.js +826 -0
- package/dist/block.mds.junction-FWZWMZJ2.js +1543 -0
- package/dist/block.mds.svcnv-UXORVLH2.js +6799 -0
- package/dist/block.svg-6KIGW4QH.js +162 -0
- package/dist/block.tk.aicheck-DK566Q4C.js +281 -0
- package/dist/block.tk.ase-2GB2VJJ6.js +363 -0
- package/dist/block.tk.bam-RQNOLY52.js +1904 -0
- package/dist/block.tk.bedgraphdot-N4YMZFO4.js +382 -0
- package/dist/block.tk.bigwig.ui-4S7L7D7D.js +209 -0
- package/dist/block.tk.hicstraw-AHFNQKCS.js +821 -0
- package/dist/block.tk.junction-7E6SNQMQ.js +2362 -0
- package/dist/block.tk.junction.textmatrixui-3C5JVYX5.js +197 -0
- package/dist/block.tk.ld-TOUCLT3W.js +97 -0
- package/dist/block.tk.menu-JCV5ORD6.js +1027 -0
- package/dist/block.tk.pgv-CUU22U6M.js +942 -0
- package/dist/brainImaging-MTQTXNNL.js +421 -0
- package/dist/chunk-2UYBBUXK.js +293 -0
- package/dist/chunk-2VPEFXEJ.js +4207 -0
- package/dist/chunk-2YC6ZVE4.js +20377 -0
- package/dist/chunk-2YC6ZVE4.js.map +7 -0
- package/dist/chunk-37MD3Y5G.js +1230 -0
- package/dist/chunk-37MD3Y5G.js.map +7 -0
- package/dist/chunk-3QHIL3V3.js +55 -0
- package/dist/chunk-44VXWKYJ.js +129 -0
- package/dist/chunk-52D6EGUS.js +95 -0
- package/dist/chunk-5FHM3L4I.js +102 -0
- package/dist/chunk-62TF2MCH.js +142 -0
- package/dist/chunk-67QM2NUK.js +6364 -0
- package/dist/chunk-6AAPHEWK.js +676 -0
- package/dist/chunk-6KPGMUHS.js +153 -0
- package/dist/chunk-6WBIZXNI.js +455 -0
- package/dist/chunk-7AAJVXEG.js +302 -0
- package/dist/chunk-AFJRAR4N.js +1271 -0
- package/dist/chunk-BBNO6JLO.js +200 -0
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- package/dist/chunk-LKADRF3Q.js +368 -0
- package/dist/chunk-MAXFRUGM.js +407 -0
- package/dist/chunk-MQN7RYCK.js +37 -0
- package/dist/chunk-OEUI4CYZ.js +470 -0
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- package/dist/chunk-Q3J3F2NU.js +205 -0
- package/dist/chunk-RYCOJY7M.js +188 -0
- package/dist/chunk-RYCOJY7M.js.map +7 -0
- package/dist/chunk-RZBV6474.js +117 -0
- package/dist/chunk-T5V4OC27.js +442 -0
- package/dist/chunk-TXJG4N6S.js +4992 -0
- package/dist/chunk-TXJG4N6S.js.map +7 -0
- package/dist/chunk-UCKSUNSJ.js +335 -0
- package/dist/chunk-W4TLYHZO.js +514 -0
- package/dist/chunk-WPZUXKIB.js +56 -0
- package/dist/chunk-XM47XD6G.js +215 -0
- package/dist/chunk-XVA3UOWD.js +263 -0
- package/dist/chunk-XVA3UOWD.js.map +7 -0
- package/dist/chunk-YIMRBXQK.js +1210 -0
- package/dist/chunk-YIMRBXQK.js.map +7 -0
- package/dist/chunk-YL7VT4QT.js +1159 -0
- package/dist/chunk-YL7VT4QT.js.map +7 -0
- package/dist/chunk-YWBUK4B7.js +291 -0
- package/dist/chunk-YWBUK4B7.js.map +7 -0
- package/dist/chunk-YZHGLSKQ.js +50 -0
- package/dist/chunk-ZGOOZK3I.js +203 -0
- package/dist/chunk-ZH2VP6Q6.js +95 -0
- package/dist/chunk-ZLOQXO5K.js +14 -0
- package/dist/chunk-ZMNDBPJU.js +100 -0
- package/dist/chunk-ZRTW6X3F.js +2784 -0
- package/dist/chunk-ZTT52MBP.js +2681 -0
- package/dist/condition-VUACUQYF.js +330 -0
- package/dist/controls-N4MPSNO4.js +39 -0
- package/dist/controls.config-PRXVODCM.js +37 -0
- package/dist/correlation-QJZUYDFH.js +96 -0
- package/dist/cuminc-JJHXW55V.js +1147 -0
- package/dist/cuminc.integration.spec-IXS2UO2O.js +676 -0
- package/dist/customdata.inputui-DUHO6M6I.js +287 -0
- package/dist/dataDownload-OFB7TYDB.js +328 -0
- package/dist/dataDownload.integration.spec-4HWDQO4C.js +191 -0
- package/dist/databrowser.ui-FGZ5SWG3.js +430 -0
- package/dist/databrowser.ui-FGZ5SWG3.js.map +7 -0
- package/dist/dictionary-BSKN37CP.js +109 -0
- package/dist/dnaMethylation-5QNEEGC6.js +36 -0
- package/dist/dnaMethylation.integration.spec-YIX3JSA7.js +201 -0
- package/dist/dofetch-KFMGQY7G.js +50 -0
- package/dist/e2pca-VX42HDYZ.js +348 -0
- package/dist/ep-B6ZNETLI.js +1254 -0
- package/dist/expclust.gdc.spec-SGECIILQ.js +305 -0
- package/dist/facet-2W5SBPGP.js +519 -0
- package/dist/gb-67KTSE2W.js +86 -0
- package/dist/gb-67KTSE2W.js.map +7 -0
- package/dist/geneExpClustering-6A7364T5.js +247 -0
- package/dist/geneExpression-NAM2UEYN.js +36 -0
- package/dist/geneExpression-WF56ODMZ.js +312 -0
- package/dist/geneExpression.unit.spec-DNE2T3WI.js +100 -0
- package/dist/geneORA-33FK2YOS.js +276 -0
- package/dist/geneVariant-C7PCNBOQ.js +37 -0
- package/dist/geneVariant-REELFRRA.js +39 -0
- package/dist/geneVariant.integration.spec-GNXUGDKL.js +196 -0
- package/dist/genefusion.ui-WO5EPJDS.js +306 -0
- package/dist/geneset-4C6ZLVMN.js +201 -0
- package/dist/geneset-4C6ZLVMN.js.map +7 -0
- package/dist/genomeBrowser.spec-VPAKTUJF.js +279 -0
- package/dist/grin2-AJFEBD43.js +852 -0
- package/dist/grin2-AJFEBD43.js.map +7 -0
- package/dist/grin2-GYHUYNEF.js +1554 -0
- package/dist/gsea-PE5WZ5ZI.js +45 -0
- package/dist/hierCluster-FH6YJHRT.js +61 -0
- package/dist/hierCluster-IFM5I5QN.js +57 -0
- package/dist/hierCluster.config-M57ZIWMB.js +38 -0
- package/dist/hierCluster.integration.spec-Z64RL7MC.js +393 -0
- package/dist/hierCluster.interactivity-CDBAJXOY.js +52 -0
- package/dist/imagePlot-NFEE6IGV.js +161 -0
- package/dist/imagePlot-NFEE6IGV.js.map +7 -0
- package/dist/importPlot-OWKXSK77.js +8 -0
- package/dist/isoformExpression-66XLJG73.js +38 -0
- package/dist/isoformExpression.unit.spec-QJX2IRHL.js +206 -0
- package/dist/launch.adhoc-JCWID253.js +40 -0
- package/dist/leftlabel.sample-5NZ6VQDN.js +257 -0
- package/dist/lollipop-BPFDEM2R.js +169 -0
- package/dist/lollipop-BPFDEM2R.js.map +7 -0
- package/dist/maf-HIS2FQXK.js +450 -0
- package/dist/maftimeline-UPJJQE23.js +591 -0
- package/dist/matrix-62CN2KXR.js +56 -0
- package/dist/matrix-SPEDEB3J.js +61 -0
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- package/dist/matrix.interactivity-OWMHUJCX.js +40 -0
- package/dist/matrix.layout-27QB6MWK.js +42 -0
- package/dist/matrix.renderers-EPXES5E4.js +36 -0
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- package/dist/mavb-M7Y74OWQ.js +730 -0
- package/dist/mds.fimo-WCDFA7HG.js +516 -0
- package/dist/mds.samplescatterplot-ZDHQ3MKJ.js +1548 -0
- package/dist/mds.survivalplot-R74DL2RA.js +481 -0
- package/dist/oncomatrix-MOITJBII.js +293 -0
- package/dist/oncomatrix.spec-NALJBPYS.js +446 -0
- package/dist/plot.2dvaf-IE2EZEFA.js +375 -0
- package/dist/plot.app-HTW6TZEH.js +39 -0
- package/dist/plot.barplot-NCQEPEOY.js +100 -0
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- package/dist/polar-4AUAZHBV.js +184 -0
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- package/dist/profile.spec-TOITKBBZ.js +78 -0
- package/dist/profileBarchart-Z4SYIYBE.js +265 -0
- package/dist/profileForms-RA7XQ2QT.js +438 -0
- package/dist/profilePlot-4BM3XZVK.js +52 -0
- package/dist/profileRadar-EYBESEPI.js +261 -0
- package/dist/profileRadarFacility-FZYTFM26.js +261 -0
- package/dist/proteinView-F6XKT2A5.js +1122 -0
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- package/dist/proteomeAbundance-3RJMRXYI.js +68 -0
- package/dist/proteomeAbundance-3RJMRXYI.js.map +7 -0
- package/dist/proteomeAbundance-65R6M4YQ.js +21 -0
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- package/dist/radar2-I6FN5SUX.js +314 -0
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- /package/dist/{violin.integration.spec-F2UD7BHC.js.map → violin.integration.spec-5EW6PLJX.js.map} +0 -0
- /package/dist/{violin.interactivity-LVDTDEPQ.js.map → violin.interactivity-RI4RURGO.js.map} +0 -0
- /package/dist/{violin.renderer-IIEIUGRI.js.map → violin.renderer-EWU2IFZE.js.map} +0 -0
- /package/dist/{vocabulary-WQRYXBRO.js.map → vocabulary-VLIGC7OP.js.map} +0 -0
package/dist/HicApp-XPZVZXB7.js
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import {
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blocklazyload
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} from "./chunk-HROKXT4K.js";
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import {
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hicParseFile
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} from "./chunk-ST644IDH.js";
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import {
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AppBase,
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ColorScale,
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axisstyle,
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first_genetrack_tolist,
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font,
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newpane,
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showErrorsWithCounter,
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tkt
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} from "./chunk-YWUVCXFS.js";
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import "./chunk-HJ6L54YS.js";
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import "./chunk-3QBZ2Y77.js";
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import {
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Menu
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} from "./chunk-HYOEWQ5P.js";
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import "./chunk-FN5XPUPH.js";
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import "./chunk-G6O3URDN.js";
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import "./chunk-LSEFWW72.js";
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import "./chunk-KWM6B3NL.js";
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import "./chunk-UCLS2SVB.js";
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import {
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dofetch3
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} from "./chunk-6ZCHECOT.js";
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import {
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StoreBase,
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getAppInit,
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getCompInit,
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getStoreInit
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} from "./chunk-MVTCBVSX.js";
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import "./chunk-2K5DSRBJ.js";
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import "./chunk-X4NI4JLQ.js";
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import "./chunk-L4QG7XZE.js";
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import "./chunk-DQC5FFGV.js";
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import "./chunk-UWYCEYML.js";
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import "./chunk-7UHUOC6F.js";
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import "./chunk-ZYY54HBU.js";
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import "./chunk-EGWVYY7K.js";
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import {
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bplen
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} from "./chunk-AMYSEKPF.js";
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import "./chunk-TV74I3Y5.js";
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import "./chunk-KSGA62R2.js";
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import {
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axisBottom,
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axisRight
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} from "./chunk-LOZEKOES.js";
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import "./chunk-TOU7EVFQ.js";
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import {
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format,
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linear
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} from "./chunk-OAWQ6LOO.js";
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import "./chunk-KYBIQBXE.js";
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import {
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pointer_default,
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select_default
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} from "./chunk-I6Y4O3RR.js";
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import "./chunk-OMR2DT66.js";
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import "./chunk-HFNDKYVF.js";
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// tracks/hic/HicStore.ts
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var HicStore = class _HicStore extends StoreBase {
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constructor(opts) {
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super(opts);
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this.views = ["genome", "chrpair", "detail", "horizontal"];
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this.type = _HicStore.type;
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this.defaultState = {
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defaultNmeth: "NONE",
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loading: true,
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minBinNum_bp: 200,
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minFragSpan: 200,
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initialBinNum: 20,
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settings: {
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widthHeightPx: 800
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}
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};
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}
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static {
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this.type = "store";
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}
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init() {
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this.state = Object.assign({}, this.defaultState, this.state);
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}
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};
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var hicStoreInit = getStoreInit(HicStore);
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HicStore.prototype.actions = {
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view_create(action) {
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if (!action.view) throw Error("view_create: missing view");
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if (!this.views.some((v) => v == action.view)) throw Error(`view_create: unknown view = ${action.view}`);
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this.state.currView = action.view;
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const opts = Object.assign(this.state, action.config);
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this.state = opts;
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},
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view_update(action) {
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if (action.view) {
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if (!this.views.some((v) => v == action.view)) throw Error(`view_update: unknown view = ${action.view}`);
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const opts = Object.assign(this.state[action.view], action.config);
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this.state[action.view] = opts;
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} else {
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const opts = Object.assign(this.state, action.config);
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this.state = opts;
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}
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},
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loading_active(action) {
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this.state.loading = action.active;
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}
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};
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// tracks/hic/dom/LoadingOverlay.ts
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var LoadingOverlay = class _LoadingOverlay {
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constructor(opts) {
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this.hasStatePreMain = true;
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this.type = _LoadingOverlay.type;
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this.app = opts.app;
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this.loadingDiv = opts.loadingDiv;
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}
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static {
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this.type = "loadingOverlay";
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}
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reactsTo(action) {
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if (action.type.startsWith("loading")) return true;
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else return false;
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}
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getState(appState) {
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return appState;
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}
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init() {
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this.loadingDiv.append("div").attr("class", "sjpp-spinner").style("display", "");
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}
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main(appState) {
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const loading = this.app.getState(appState).loading;
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this.loadingDiv.style("display", loading ? "" : "none");
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}
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};
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var loadingInit = getCompInit(LoadingOverlay);
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// tracks/hic/dom/ColorizeElement.ts
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var ColorizeElement = class {
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colorizeElement(xCoord, yCoord, v, obj, width, height, bpMinV, bpMaxV, currView) {
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if (v >= 0) {
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const p = v >= bpMaxV ? 0 : v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV - v) / bpMaxV);
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const positiveFill = `rgb(255, ${p}, ${p})`;
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if (currView === "genome") {
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obj.ctx.fillStyle = positiveFill;
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obj.ctx2.fillStyle = positiveFill;
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} else {
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obj.fillStyle = positiveFill;
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}
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} else {
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const p = v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV + v) / bpMaxV);
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const negativeFill = `rgb(${p}, ${p}, 255)`;
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if (currView === "genome") {
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obj.ctx.fillStyle = negativeFill;
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obj.ctx2.fillStyle = negativeFill;
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} else {
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obj.fillStyle = negativeFill;
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}
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}
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if (currView === "genome") {
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obj.ctx.fillRect(yCoord, xCoord, width, height);
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obj.ctx2.fillRect(xCoord, yCoord, width, height);
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} else {
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obj.fillRect(xCoord, yCoord, width, height);
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}
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}
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};
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// tracks/hic/data/Resolution.ts
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var Resolution = class {
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constructor(error) {
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this.error = error;
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}
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getResolution(state, hic) {
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if (state.currView == "genome") return hic["bpresolution"][0];
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if (state.currView == "chrpair") {
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const resolution = this.getChrPairResolution(hic, state.x, state.y, state.minBinNum_bp);
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return resolution;
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} else if (state.currView == "detail") {
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const maxBpWidth = Math.max(state.x.stop - state.x.start, state.y.stop - state.y.start);
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let resolution = this.findResFromArray(maxBpWidth, state.minBinNum_bp, hic.bpresolution);
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if (resolution == null && !hic.enzyme) {
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resolution = hic.bpresolution[hic.bpresolution.length - 1];
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}
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return resolution;
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} else {
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this.error(`Unknown view: ${state.currView}`);
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throw `Unknown view: ${state.currView}`;
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}
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}
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getChrPairResolution(hic, x, y, minBinNum_bp) {
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const chrxlen = hic.genome.chrlookup[x.chr.toUpperCase()].len;
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const chrylen = hic.genome.chrlookup[y.chr.toUpperCase()].len;
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const maxchrlen = Math.max(chrxlen, chrylen);
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const resolution = this.findResFromArray(maxchrlen, minBinNum_bp, hic.bpresolution);
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if (resolution == null) {
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this.error(`No suitable resolution for ${x.chr}-${y.chr} pair.`);
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return;
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}
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return resolution;
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}
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findResFromArray(max, defaultValue, resolutionArray, returnNum) {
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let resolution = null;
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for (const res of resolutionArray) {
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if (max / res > defaultValue) {
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resolution = res;
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break;
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}
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}
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if (returnNum && resolution == null) {
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resolution = resolutionArray[resolutionArray.length - 1];
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}
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return resolution;
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}
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getDefaultViewSpan(hic, x, y, initialBinNum, minBinNum_bp) {
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const chrpairResolution = this.getChrPairResolution(hic, x, y, minBinNum_bp);
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if (!chrpairResolution) return;
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return chrpairResolution * initialBinNum;
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}
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};
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// tracks/hic/data/Positions.ts
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var Positions = class {
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constructor(error, minBinNum_bp) {
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this.error = error;
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this.resolution = new Resolution(this.error);
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this.minBinNum_bp = minBinNum_bp;
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}
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/**
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*
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* @param x x coordinate of pointer
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* @param y y coordinate of pointer
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* @param binpx
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* @param chrx x chr from state
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* @param chry y chr from state
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* @param hic
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* @param initialBinNum Set in the state
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* @returns
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*/
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setPosition(x, y, binpx, chrx, chry, hic, initialBinNum) {
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const resolution = this.resolution.getChrPairResolution(hic, chrx, chry, this.minBinNum_bp);
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const viewrangebpw = resolution * initialBinNum;
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let coordx = Math.max(1, Math.floor(x * resolution / binpx) - viewrangebpw / 2);
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let coordy = Math.max(1, Math.floor(y * resolution / binpx) - viewrangebpw / 2);
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{
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const lenx = hic.genome.chrlookup[chrx.chr.toUpperCase()].len;
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if (coordx + viewrangebpw >= lenx) {
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coordx = lenx - viewrangebpw;
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}
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const leny = hic.genome.chrlookup[chry.chr.toUpperCase()].len;
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if (coordy + viewrangebpw > leny) {
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coordy = leny - viewrangebpw;
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}
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}
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const xObj = {
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chr: chrx.chr,
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start: coordx,
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stop: coordx + viewrangebpw
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};
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const yObj = {
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chr: chry.chr,
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start: coordy,
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stop: coordy + viewrangebpw
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};
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return [xObj, yObj];
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}
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};
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// tracks/hic/data/GridElementsFormattedData.ts
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var GridElementsFormattedData = class {
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/**
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* Format the data for the grid elements.
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* @param items The data to format.
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* @param binpx The bin size in pixels.
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* @param resolution The resolution.
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* @param isFirstChrX Whether the first chromosome is X. Used for chrpair view.
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* @param isIntraChr Whether the data is intra-chromosomal. Used for chrpair view
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* @returns The formatted data.
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*/
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formatData(view, items, binpx, resolution, isFirstChrX, isIntraChr) {
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const formattedData = [];
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for (const [xCoord, yCoord, value] of items) {
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const xPx = Math.floor(xCoord / resolution) * binpx;
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const yPx = Math.floor(yCoord / resolution) * binpx;
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if (view == "genome") {
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formattedData.push([xPx, yPx, value]);
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}
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if (view == "chrpair") {
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const x = isFirstChrX ? xPx : yPx;
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const y = isFirstChrX ? yPx : xPx;
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formattedData.push([x, y, value]);
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if (isIntraChr) {
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formattedData.push([y, x, value]);
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}
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}
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}
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return formattedData;
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}
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};
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// tracks/hic/data/FirstChrX.ts
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-
var FirstChrX = class {
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-
constructor(chrorder, chrx, chry) {
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this.chrorder = chrorder;
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|
-
this.chrx = chrx;
|
|
310
|
-
this.chry = chry;
|
|
311
|
-
}
|
|
312
|
-
isFirstX() {
|
|
313
|
-
if (this.chrx == this.chry) return true;
|
|
314
|
-
return this.chrorder.indexOf(this.chrx) < this.chrorder.indexOf(this.chry);
|
|
315
|
-
}
|
|
316
|
-
};
|
|
317
|
-
|
|
318
|
-
// tracks/hic/chrpair/ChrPairView.ts
|
|
319
|
-
var ChrPairView = class {
|
|
320
|
-
constructor(opts) {
|
|
321
|
-
this.binpx = 1;
|
|
322
|
-
/** padding on the ends of x/y chr coordinate axes */
|
|
323
|
-
this.axispad = 10;
|
|
324
|
-
this.axisLabelFontSize = 15;
|
|
325
|
-
this.calcResolution = null;
|
|
326
|
-
this.data = [];
|
|
327
|
-
this.app = opts.app;
|
|
328
|
-
this.hic = opts.hic;
|
|
329
|
-
this.plotDiv = opts.plotDiv;
|
|
330
|
-
this.items = opts.items;
|
|
331
|
-
this.parent = opts.parent;
|
|
332
|
-
this.chrxlen = this.hic.genome.chrlookup[this.parent("state").x.chr.toUpperCase()].len;
|
|
333
|
-
this.chrylen = this.hic.genome.chrlookup[this.parent("state").y.chr.toUpperCase()].len;
|
|
334
|
-
this.maxchrlen = Math.max(this.chrxlen, this.chrylen);
|
|
335
|
-
this.colorizeElement = new ColorizeElement();
|
|
336
|
-
this.positions = new Positions(opts.error, this.parent("state").minBinNum_bp);
|
|
337
|
-
this.formattedData = new GridElementsFormattedData();
|
|
338
|
-
}
|
|
339
|
-
setDefaultBinpx() {
|
|
340
|
-
if (this.calcResolution == null) return;
|
|
341
|
-
while (this.binpx * this.maxchrlen / this.calcResolution < 600) {
|
|
342
|
-
this.binpx++;
|
|
343
|
-
}
|
|
344
|
-
}
|
|
345
|
-
renderAxes() {
|
|
346
|
-
if (this.calcResolution == null) return;
|
|
347
|
-
const svgY = this.plotDiv.yAxis.append("svg");
|
|
348
|
-
const h = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
|
|
349
|
-
svgY.attr("width", 100).attr("height", this.axispad * 2 + h);
|
|
350
|
-
svgY.append("g").attr("data-testid", "sjpp-chrpair-svg-y").attr("transform", "translate(80," + (this.axispad + h / 2) + ")").append("text").text(this.parent("state").y.chr).attr("text-anchor", "middle").attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("dominant-baseline", "central").attr("transform", "rotate(90)");
|
|
351
|
-
axisstyle({
|
|
352
|
-
axis: svgY.append("g").attr("transform", `translate(1, ${this.axispad})`).call(axisRight(linear().domain([0, this.chrylen]).range([0, h])).tickFormat(format(".2s"))),
|
|
353
|
-
showline: true
|
|
354
|
-
});
|
|
355
|
-
const svgX = this.plotDiv.xAxis.append("svg").style("margin-top", "-4px");
|
|
356
|
-
const w = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
|
|
357
|
-
svgX.attr("height", 100).attr("width", this.axispad * 2 + w);
|
|
358
|
-
svgX.append("text").attr("data-testid", "sjpp-chrpair-svg-x").text(this.parent("state").x.chr).attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("x", this.axispad + w / 2).attr("text-anchor", "middle").attr("y", 60);
|
|
359
|
-
axisstyle({
|
|
360
|
-
axis: svgX.append("g").attr("transform", "translate(" + this.axispad + ",1)").call(axisBottom(linear().domain([0, this.chrxlen]).range([0, w])).tickFormat(format(".2s"))),
|
|
361
|
-
showline: true
|
|
362
|
-
});
|
|
363
|
-
}
|
|
364
|
-
renderCanvas() {
|
|
365
|
-
const initDetailView = this.initDetailView.bind(this);
|
|
366
|
-
this.canvas = this.plotDiv.plot.append("canvas").attr("data-testid", "sjpp-chrpair-canvas").style("margin", this.axispad + "px").on("click", async function(event) {
|
|
367
|
-
const [x, y] = pointer_default(event, this);
|
|
368
|
-
initDetailView(x, y);
|
|
369
|
-
}).node();
|
|
370
|
-
this.canvas.width = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
|
|
371
|
-
this.canvas.height = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
|
|
372
|
-
this.ctx = this.canvas.getContext("2d");
|
|
373
|
-
}
|
|
374
|
-
initDetailView(x, y) {
|
|
375
|
-
const [xObj, yObj] = this.positions.setPosition(
|
|
376
|
-
x,
|
|
377
|
-
y,
|
|
378
|
-
this.binpx,
|
|
379
|
-
this.parent("state").x,
|
|
380
|
-
this.parent("state").y,
|
|
381
|
-
this.hic,
|
|
382
|
-
this.parent("state").initialBinNum
|
|
383
|
-
);
|
|
384
|
-
this.app.dispatch({
|
|
385
|
-
type: "view_create",
|
|
386
|
-
view: "detail",
|
|
387
|
-
config: {
|
|
388
|
-
x: xObj,
|
|
389
|
-
y: yObj
|
|
390
|
-
}
|
|
391
|
-
});
|
|
392
|
-
}
|
|
393
|
-
render() {
|
|
394
|
-
this.calcResolution = this.parent("calcResolution");
|
|
395
|
-
this.setDefaultBinpx();
|
|
396
|
-
this.renderAxes();
|
|
397
|
-
this.renderCanvas();
|
|
398
|
-
this.update(this.items);
|
|
399
|
-
}
|
|
400
|
-
update(items) {
|
|
401
|
-
this.items = items;
|
|
402
|
-
const firstisx = new FirstChrX(this.hic.chrorder, this.parent("state").x.chr, this.parent("state").y.chr).isFirstX();
|
|
403
|
-
const isintrachr = this.parent("state").x.chr === this.parent("state").y.chr;
|
|
404
|
-
this.data = this.formattedData.formatData(
|
|
405
|
-
"chrpair",
|
|
406
|
-
items.items,
|
|
407
|
-
this.binpx,
|
|
408
|
-
this.calcResolution,
|
|
409
|
-
firstisx,
|
|
410
|
-
isintrachr
|
|
411
|
-
);
|
|
412
|
-
this.ctx.clearRect(0, 0, this.canvas.width, this.canvas.height);
|
|
413
|
-
for (const [x, y, v] of this.data) {
|
|
414
|
-
this.colorizeElement.colorizeElement(
|
|
415
|
-
x,
|
|
416
|
-
y,
|
|
417
|
-
v,
|
|
418
|
-
this.ctx,
|
|
419
|
-
this.binpx,
|
|
420
|
-
//width
|
|
421
|
-
this.binpx,
|
|
422
|
-
//height
|
|
423
|
-
this.parent("min"),
|
|
424
|
-
this.parent("max"),
|
|
425
|
-
"chrpair"
|
|
426
|
-
);
|
|
427
|
-
}
|
|
428
|
-
this.app.dispatch({ type: "loading_active", active: false });
|
|
429
|
-
}
|
|
430
|
-
};
|
|
431
|
-
|
|
432
|
-
// tracks/hic/horizontal/HorizontalView.ts
|
|
433
|
-
var HorizontalView = class {
|
|
434
|
-
constructor(opts) {
|
|
435
|
-
/** Defaults*/
|
|
436
|
-
this.maxPercentage = 5;
|
|
437
|
-
this.subPanelPxWidth = 600;
|
|
438
|
-
this.borderColor = "rgba(200,0,0,.1)";
|
|
439
|
-
this.app = opts.app;
|
|
440
|
-
this.hic = opts.hic;
|
|
441
|
-
this.plotDiv = opts.plotDiv;
|
|
442
|
-
this.items = opts.items;
|
|
443
|
-
this.parent = opts.parent;
|
|
444
|
-
}
|
|
445
|
-
setRunPpTracks() {
|
|
446
|
-
const tracks = [
|
|
447
|
-
{
|
|
448
|
-
type: "hicstraw",
|
|
449
|
-
file: this.hic.file,
|
|
450
|
-
url: this.hic.url,
|
|
451
|
-
name: this.hic.name,
|
|
452
|
-
enzyme: this.hic.enzyme,
|
|
453
|
-
maxpercentage: this.maxPercentage,
|
|
454
|
-
pyramindup: 1
|
|
455
|
-
}
|
|
456
|
-
];
|
|
457
|
-
if (this.hic.tklst) {
|
|
458
|
-
for (const t of this.hic.tklst) {
|
|
459
|
-
tracks.push(t);
|
|
460
|
-
}
|
|
461
|
-
}
|
|
462
|
-
first_genetrack_tolist(this.hic.genome, tracks);
|
|
463
|
-
return tracks;
|
|
464
|
-
}
|
|
465
|
-
setRunPpArgs(tracks) {
|
|
466
|
-
const arg = {
|
|
467
|
-
holder: this.plotDiv.plot,
|
|
468
|
-
hostURL: this.hic.hostURL,
|
|
469
|
-
jwt: this.hic.jwt,
|
|
470
|
-
genome: this.hic.genome,
|
|
471
|
-
nobox: 1,
|
|
472
|
-
tklst: tracks
|
|
473
|
-
};
|
|
474
|
-
const state = this.parent("state");
|
|
475
|
-
if (state.x.chr == state.y.chr && Math.max(state.x.start, state.y.start) < Math.min(state.x.stop, state.y.stop)) {
|
|
476
|
-
arg["chr"] = state.x.chr;
|
|
477
|
-
arg["start"] = Math.min(state.x.start, state.y.start);
|
|
478
|
-
arg["stop"] = Math.max(state.x.stop, state.y.stop);
|
|
479
|
-
} else {
|
|
480
|
-
arg["chr"] = state.x.chr;
|
|
481
|
-
arg["start"] = state.x.start;
|
|
482
|
-
arg["stop"] = state.x.stop;
|
|
483
|
-
arg["width"] = this.subPanelPxWidth;
|
|
484
|
-
arg["subpanels"] = [
|
|
485
|
-
{
|
|
486
|
-
chr: state.y.chr,
|
|
487
|
-
start: state.y.start,
|
|
488
|
-
stop: state.y.stop,
|
|
489
|
-
width: this.subPanelPxWidth,
|
|
490
|
-
leftpad: 10,
|
|
491
|
-
leftborder: this.borderColor
|
|
492
|
-
}
|
|
493
|
-
];
|
|
494
|
-
}
|
|
495
|
-
return arg;
|
|
496
|
-
}
|
|
497
|
-
render() {
|
|
498
|
-
const tracks = this.setRunPpTracks();
|
|
499
|
-
const arg = this.setRunPpArgs(tracks);
|
|
500
|
-
blocklazyload(arg);
|
|
501
|
-
}
|
|
502
|
-
// update() {
|
|
503
|
-
// //Not required.
|
|
504
|
-
// //If controls are added back. Implement changes here.
|
|
505
|
-
// }
|
|
506
|
-
};
|
|
507
|
-
|
|
508
|
-
// tracks/hic/detail/DetailBlock.ts
|
|
509
|
-
var DetailBlock = class {
|
|
510
|
-
constructor(app, hic, blockwidth, bbmargin, holder, isYblock) {
|
|
511
|
-
/** Defaults */
|
|
512
|
-
this.leftheadw = 20;
|
|
513
|
-
this.rightheadw = 40;
|
|
514
|
-
this.lpad = 1;
|
|
515
|
-
this.rpad = 1;
|
|
516
|
-
this.firstRender = true;
|
|
517
|
-
this.app = app;
|
|
518
|
-
this.hic = hic;
|
|
519
|
-
this.width = blockwidth;
|
|
520
|
-
this.bbmargin = bbmargin;
|
|
521
|
-
this.holder = holder;
|
|
522
|
-
this.isYblock = isYblock;
|
|
523
|
-
this.bbw = this.leftheadw + this.lpad + this.width + this.rpad + this.rightheadw + 2 * this.bbmargin;
|
|
524
|
-
this.defaultLeft = this.bbmargin + this.leftheadw + this.lpad;
|
|
525
|
-
this.defaultTop = this.bbmargin + this.rightheadw + this.rpad;
|
|
526
|
-
}
|
|
527
|
-
setArgs(chrObj) {
|
|
528
|
-
const runPpArgs = {
|
|
529
|
-
hostURL: this.hic.hostURL,
|
|
530
|
-
genome: this.hic.genome,
|
|
531
|
-
holder: this.holder,
|
|
532
|
-
noresize: true,
|
|
533
|
-
nobox: true,
|
|
534
|
-
butrowbottom: true,
|
|
535
|
-
style: {
|
|
536
|
-
margin: `${this.bbmargin}px`
|
|
537
|
-
},
|
|
538
|
-
width: this.width,
|
|
539
|
-
leftheadw: this.leftheadw,
|
|
540
|
-
chr: chrObj.chr,
|
|
541
|
-
start: chrObj.start,
|
|
542
|
-
stop: chrObj.stop,
|
|
543
|
-
rightheadw: this.rightheadw,
|
|
544
|
-
tklst: [],
|
|
545
|
-
rotated: this.isYblock,
|
|
546
|
-
showreverse: this.isYblock
|
|
547
|
-
};
|
|
548
|
-
first_genetrack_tolist(this.hic.genome, runPpArgs.tklst);
|
|
549
|
-
return runPpArgs;
|
|
550
|
-
}
|
|
551
|
-
setMethods(canvasHolder, canvas, sheath) {
|
|
552
|
-
const runPpMethods = {
|
|
553
|
-
onloadalltk_always: () => {
|
|
554
|
-
this.onload(canvasHolder, canvas, sheath);
|
|
555
|
-
},
|
|
556
|
-
onpanning: (xoff) => this.onpanning(xoff, canvas)
|
|
557
|
-
};
|
|
558
|
-
if (this.isYblock) {
|
|
559
|
-
runPpMethods["onsetheight"] = (bbh) => {
|
|
560
|
-
this.holder.transition().style("left", `${bbh + this.bbmargin + 30}px`);
|
|
561
|
-
};
|
|
562
|
-
}
|
|
563
|
-
return runPpMethods;
|
|
564
|
-
}
|
|
565
|
-
onload(canvasHolder, canvas, sheath) {
|
|
566
|
-
this.bbw = this.block.leftheadw + this.block.lpad + this.block.width + this.block.rpad + this.block.rightheadw + 2 * this.bbmargin;
|
|
567
|
-
if (this.isYblock) {
|
|
568
|
-
sheath.transition().style("height", `${this.bbw}px`);
|
|
569
|
-
canvasHolder.style("height", `${this.bbw}px`);
|
|
570
|
-
} else canvasHolder.style("width", `${this.bbw}px`);
|
|
571
|
-
if (this.isYblock) {
|
|
572
|
-
this.defaultTop = this.bbmargin + this.block.rightheadw + this.block.rpad;
|
|
573
|
-
canvas.style("top", `${this.defaultTop}px`);
|
|
574
|
-
} else {
|
|
575
|
-
this.defaultLeft = this.bbmargin + this.block.leftheadw + this.block.lpad;
|
|
576
|
-
canvas.style("left", `${this.defaultLeft}px`);
|
|
577
|
-
}
|
|
578
|
-
const config = {
|
|
579
|
-
[this.isYblock ? "y" : "x"]: {
|
|
580
|
-
chr: this.block.rglst[0].chr,
|
|
581
|
-
start: this.block.rglst[0].start,
|
|
582
|
-
stop: this.block.rglst[0].stop
|
|
583
|
-
}
|
|
584
|
-
};
|
|
585
|
-
if (this.firstRender == false) {
|
|
586
|
-
this.app.dispatch({
|
|
587
|
-
type: "view_update",
|
|
588
|
-
config
|
|
589
|
-
});
|
|
590
|
-
} else {
|
|
591
|
-
this.firstRender = false;
|
|
592
|
-
}
|
|
593
|
-
}
|
|
594
|
-
onpanning(xoff, canvas) {
|
|
595
|
-
if (!this.isYblock) canvas.style("left", `${xoff + this.defaultLeft}px`);
|
|
596
|
-
else canvas.style("top", `${-xoff + this.defaultTop}px`);
|
|
597
|
-
}
|
|
598
|
-
async loadBlock(chrObj, canvasHolder, canvas, sheath) {
|
|
599
|
-
const runPpArgs = this.setArgs(chrObj);
|
|
600
|
-
const runPpMethods = this.isYblock ? this.setMethods(canvasHolder, canvas, sheath) : this.setMethods(canvasHolder, canvas);
|
|
601
|
-
const args = Object.assign(runPpArgs, runPpMethods);
|
|
602
|
-
await blocklazyload(args).then(async (block) => {
|
|
603
|
-
this.block = block;
|
|
604
|
-
});
|
|
605
|
-
}
|
|
606
|
-
};
|
|
607
|
-
|
|
608
|
-
// tracks/hic/data/DetailDataFetcher.ts
|
|
609
|
-
var DetailDataFetcher = class {
|
|
610
|
-
constructor(errList) {
|
|
611
|
-
this.obj = {
|
|
612
|
-
rglst: []
|
|
613
|
-
};
|
|
614
|
-
this.errList = errList;
|
|
615
|
-
}
|
|
616
|
-
isFragData(hic, resolution) {
|
|
617
|
-
if (resolution != null) return;
|
|
618
|
-
if (!hic.enzyme) {
|
|
619
|
-
resolution = hic.bpresolution[hic.bpresolution.length - 1];
|
|
620
|
-
return;
|
|
621
|
-
}
|
|
622
|
-
}
|
|
623
|
-
formatFragArgs(enzymefile, chr) {
|
|
624
|
-
const arg = {
|
|
625
|
-
getdata: 1,
|
|
626
|
-
getBED: 1,
|
|
627
|
-
file: enzymefile,
|
|
628
|
-
rglst: [chr]
|
|
629
|
-
};
|
|
630
|
-
return arg;
|
|
631
|
-
}
|
|
632
|
-
/**
|
|
633
|
-
* @param arg Formated obj from either fn above
|
|
634
|
-
* @param errList
|
|
635
|
-
* @returns
|
|
636
|
-
*/
|
|
637
|
-
async getBedData(arg) {
|
|
638
|
-
try {
|
|
639
|
-
return await dofetch3("tkbedj", { method: "POST", body: JSON.stringify(arg) });
|
|
640
|
-
} catch (e) {
|
|
641
|
-
this.errList.push(e.message || e);
|
|
642
|
-
if (e.stack) console.error(e.stack);
|
|
643
|
-
}
|
|
644
|
-
}
|
|
645
|
-
async getXFragData(hic, resolution, chrx) {
|
|
646
|
-
this.isFragData(hic, resolution);
|
|
647
|
-
if (!hic.enzymefile) return;
|
|
648
|
-
const reqArgs = this.formatFragArgs(hic.enzymefile, chrx);
|
|
649
|
-
return await this.getBedData(reqArgs);
|
|
650
|
-
}
|
|
651
|
-
async getYFragData(hic, chry) {
|
|
652
|
-
const reqArgs = this.formatFragArgs(hic.enzymefile, chry);
|
|
653
|
-
return await this.getBedData(reqArgs);
|
|
654
|
-
}
|
|
655
|
-
/**
|
|
656
|
-
* Separate request from data fetch
|
|
657
|
-
* Returns the additional fragment data
|
|
658
|
-
* @param fragCoords
|
|
659
|
-
*/
|
|
660
|
-
async fetchData(hic, detailView, resolution, x, y, fragCoords) {
|
|
661
|
-
const fragStrawArgs = {
|
|
662
|
-
matrixType: detailView.matrixType,
|
|
663
|
-
file: hic.file,
|
|
664
|
-
url: hic.url,
|
|
665
|
-
pos1: this.determinePosition(hic, x, fragCoords?.x),
|
|
666
|
-
pos2: this.determinePosition(hic, y, fragCoords?.y),
|
|
667
|
-
nmeth: detailView.nmeth,
|
|
668
|
-
resolution
|
|
669
|
-
};
|
|
670
|
-
if (fragCoords) fragStrawArgs["isfrag"] = true;
|
|
671
|
-
try {
|
|
672
|
-
const data = dofetch3("hicdata?", {
|
|
673
|
-
method: "POST",
|
|
674
|
-
body: JSON.stringify(fragStrawArgs)
|
|
675
|
-
});
|
|
676
|
-
if (data.error) {
|
|
677
|
-
this.errList.push(data.error);
|
|
678
|
-
}
|
|
679
|
-
return data;
|
|
680
|
-
} catch (e) {
|
|
681
|
-
this.errList.push(e.message || e);
|
|
682
|
-
if (e.stack) console.error(e.stack);
|
|
683
|
-
}
|
|
684
|
-
}
|
|
685
|
-
determinePosition(hic, chr, fragCoord) {
|
|
686
|
-
if (fragCoord) {
|
|
687
|
-
return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${fragCoord.start}:${fragCoord.stop}`;
|
|
688
|
-
} else {
|
|
689
|
-
return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${chr.start}:${chr.stop}`;
|
|
690
|
-
}
|
|
691
|
-
}
|
|
692
|
-
};
|
|
693
|
-
|
|
694
|
-
// tracks/hic/data/ParseFragData.ts
|
|
695
|
-
var ParseFragData = class {
|
|
696
|
-
constructor(errLst, items) {
|
|
697
|
-
this.id2coord = /* @__PURE__ */ new Map();
|
|
698
|
-
this.min = null;
|
|
699
|
-
this.max = null;
|
|
700
|
-
this.items = [];
|
|
701
|
-
this.errLst = errLst;
|
|
702
|
-
for (const i of items) {
|
|
703
|
-
if (!i.rest || !i.rest[0]) {
|
|
704
|
-
this.errLst.push("items[].rest data problem");
|
|
705
|
-
}
|
|
706
|
-
const id = Number.parseInt(i.rest[0]);
|
|
707
|
-
if (Number.isNaN(id)) {
|
|
708
|
-
this.errLst.push(`${i.start}.${i.stop} invalid fragment id: ${i.rest[0]}`);
|
|
709
|
-
}
|
|
710
|
-
this.id2coord.set(id, [i.start, i.stop]);
|
|
711
|
-
if (this.min == null) {
|
|
712
|
-
this.min = id;
|
|
713
|
-
this.max = id;
|
|
714
|
-
} else {
|
|
715
|
-
this.min = Math.min(this.min, id);
|
|
716
|
-
this.max = Math.max(this.max, id);
|
|
717
|
-
}
|
|
718
|
-
}
|
|
719
|
-
}
|
|
720
|
-
};
|
|
721
|
-
|
|
722
|
-
// tracks/hic/data/DetailDataMapper.ts
|
|
723
|
-
var DetailDataMapper = class {
|
|
724
|
-
constructor(hic, errList, parent) {
|
|
725
|
-
this.frag = {
|
|
726
|
-
x: {},
|
|
727
|
-
y: {}
|
|
728
|
-
};
|
|
729
|
-
this.hic = hic;
|
|
730
|
-
this.errList = errList;
|
|
731
|
-
this.dataFetcher = new DetailDataFetcher(errList);
|
|
732
|
-
this.parent = parent;
|
|
733
|
-
}
|
|
734
|
-
async getFragData(chrx, chry) {
|
|
735
|
-
try {
|
|
736
|
-
const xFragData = await this.dataFetcher.getXFragData(this.hic, this.parent("calcResolution"), chrx);
|
|
737
|
-
if (xFragData) {
|
|
738
|
-
if (!xFragData.items) {
|
|
739
|
-
this.errList.push(`No fragment data returned for ${chrx.chr}:${chrx.start}-${chrx.stop}`);
|
|
740
|
-
return;
|
|
741
|
-
}
|
|
742
|
-
const xParse = new ParseFragData(this.errList, xFragData.items);
|
|
743
|
-
if (this.errList.length) return;
|
|
744
|
-
this.frag.x = {
|
|
745
|
-
id2coord: xParse.id2coord,
|
|
746
|
-
start: xParse.min,
|
|
747
|
-
stop: xParse.max
|
|
748
|
-
};
|
|
749
|
-
const yFragData = await this.dataFetcher.getYFragData(this.hic, chry);
|
|
750
|
-
if (this.errList.length) return;
|
|
751
|
-
if (yFragData) {
|
|
752
|
-
if (!yFragData.items) {
|
|
753
|
-
this.errList.push(`No fragment data returned for ${chry.chr}:${chry.start}-${chry.stop}`);
|
|
754
|
-
return;
|
|
755
|
-
}
|
|
756
|
-
const yParse = new ParseFragData(this.errList, yFragData.items);
|
|
757
|
-
if (this.errList.length) return;
|
|
758
|
-
this.frag.y = {
|
|
759
|
-
id2coord: /* @__PURE__ */ new Map(),
|
|
760
|
-
start: yParse.min,
|
|
761
|
-
stop: yParse.max
|
|
762
|
-
};
|
|
763
|
-
this.determineMap(yParse.id2coord, chrx, chry);
|
|
764
|
-
}
|
|
765
|
-
}
|
|
766
|
-
} catch (e) {
|
|
767
|
-
this.errList.push(e.message || e);
|
|
768
|
-
if (e.stack) console.error(e.stack);
|
|
769
|
-
}
|
|
770
|
-
}
|
|
771
|
-
determineMap(map, chrx, chry) {
|
|
772
|
-
if (chrx.chr == chry.chr) {
|
|
773
|
-
for (const [id, pos] of map) {
|
|
774
|
-
this.frag.x["id2coord"].set(id, pos);
|
|
775
|
-
}
|
|
776
|
-
this.frag.y["id2coord"] = this.frag.x["id2coord"];
|
|
777
|
-
} else {
|
|
778
|
-
this.frag.y["id2coord"] = map;
|
|
779
|
-
}
|
|
780
|
-
}
|
|
781
|
-
async getData(chrx, chry, fragCoords) {
|
|
782
|
-
return await this.dataFetcher.fetchData(
|
|
783
|
-
this.hic,
|
|
784
|
-
this.parent("state")["detail"],
|
|
785
|
-
this.parent("calcResolution"),
|
|
786
|
-
chrx,
|
|
787
|
-
chry,
|
|
788
|
-
fragCoords
|
|
789
|
-
);
|
|
790
|
-
}
|
|
791
|
-
};
|
|
792
|
-
|
|
793
|
-
// tracks/hic/data/DetailCoodinates.ts
|
|
794
|
-
var DetailCoordinates = class {
|
|
795
|
-
constructor(hic, errlist) {
|
|
796
|
-
this.hic = hic;
|
|
797
|
-
this.errlist = errlist;
|
|
798
|
-
}
|
|
799
|
-
getCoordinates(chrx, chry, data, resolution, widthHeightPx, fragData) {
|
|
800
|
-
const isFirstX = new FirstChrX(this.hic.chrorder, chrx.chr, chry.chr).isFirstX();
|
|
801
|
-
const isintrachr = chrx.chr == chry.chr;
|
|
802
|
-
const xpxbp = widthHeightPx / (chrx.stop - chrx.start);
|
|
803
|
-
const ypxbp = widthHeightPx / (chry.stop - chry.start);
|
|
804
|
-
const list = this.calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData);
|
|
805
|
-
return list;
|
|
806
|
-
}
|
|
807
|
-
calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData) {
|
|
808
|
-
const list = [];
|
|
809
|
-
for (const [xCoord, yCoord, value] of data.items) {
|
|
810
|
-
let coord1, coord2, span1, span2;
|
|
811
|
-
if (fragData) {
|
|
812
|
-
const idx_start = isFirstX ? xCoord : yCoord;
|
|
813
|
-
const idy_start = isFirstX ? yCoord : xCoord;
|
|
814
|
-
if (fragData.x.id2coord.has(idx_start)) {
|
|
815
|
-
const [a, b] = fragData.x.id2coord.get(idx_start);
|
|
816
|
-
coord1 = a;
|
|
817
|
-
span1 = b - a;
|
|
818
|
-
} else {
|
|
819
|
-
this.errlist.push(`[x id error] x: ${idx_start} y: ${idy_start}`);
|
|
820
|
-
continue;
|
|
821
|
-
}
|
|
822
|
-
{
|
|
823
|
-
const id_stop = idx_start + resolution;
|
|
824
|
-
if (fragData.x.id2coord.has(id_stop)) {
|
|
825
|
-
const ab = fragData.x.id2coord.get(id_stop);
|
|
826
|
-
span1 = ab[1] - coord1;
|
|
827
|
-
}
|
|
828
|
-
}
|
|
829
|
-
if (fragData.y.id2coord.has(idy_start)) {
|
|
830
|
-
const [a, b] = fragData.y.id2coord.get(idy_start);
|
|
831
|
-
coord2 = a;
|
|
832
|
-
span2 = b - a;
|
|
833
|
-
} else {
|
|
834
|
-
this.errlist.push(`[y id error] x: ${idx_start} y: ${idy_start}`);
|
|
835
|
-
continue;
|
|
836
|
-
}
|
|
837
|
-
{
|
|
838
|
-
const id_stop = idy_start + resolution;
|
|
839
|
-
if (fragData.y.id2coord.has(id_stop)) {
|
|
840
|
-
const ab = fragData.y.id2coord.get(id_stop);
|
|
841
|
-
span2 = ab[1] - coord2;
|
|
842
|
-
}
|
|
843
|
-
}
|
|
844
|
-
} else {
|
|
845
|
-
coord1 = isFirstX ? xCoord : yCoord;
|
|
846
|
-
coord2 = isFirstX ? yCoord : xCoord;
|
|
847
|
-
span1 = resolution;
|
|
848
|
-
span2 = resolution;
|
|
849
|
-
}
|
|
850
|
-
if (isintrachr) {
|
|
851
|
-
if (coord1 > chrx.start - span1 && coord1 < chrx.stop && coord2 > chry.start - span2 && coord2 < chry.stop) {
|
|
852
|
-
list.push([
|
|
853
|
-
Math.floor((coord1 - chrx.start) * xpxbp),
|
|
854
|
-
Math.floor((coord2 - chry.start) * ypxbp),
|
|
855
|
-
Math.ceil(span1 * xpxbp),
|
|
856
|
-
Math.ceil(span2 * ypxbp),
|
|
857
|
-
value
|
|
858
|
-
]);
|
|
859
|
-
}
|
|
860
|
-
if (coord2 > chrx.start - span2 && coord2 < chrx.stop && coord1 > chry.start && coord1 < chry.stop) {
|
|
861
|
-
list.push([
|
|
862
|
-
Math.floor((coord2 - chrx.start) * xpxbp),
|
|
863
|
-
Math.floor((coord1 - chry.start) * ypxbp),
|
|
864
|
-
Math.ceil(span2 * xpxbp),
|
|
865
|
-
Math.ceil(span1 * ypxbp),
|
|
866
|
-
value
|
|
867
|
-
]);
|
|
868
|
-
}
|
|
869
|
-
continue;
|
|
870
|
-
}
|
|
871
|
-
list.push([
|
|
872
|
-
Math.floor((coord1 - chrx.start) * xpxbp),
|
|
873
|
-
Math.floor((coord2 - chry.start) * ypxbp),
|
|
874
|
-
Math.ceil(span1 * xpxbp),
|
|
875
|
-
Math.ceil(span2 * ypxbp),
|
|
876
|
-
value
|
|
877
|
-
]);
|
|
878
|
-
}
|
|
879
|
-
return list;
|
|
880
|
-
}
|
|
881
|
-
};
|
|
882
|
-
|
|
883
|
-
// tracks/hic/detail/DetailView.ts
|
|
884
|
-
var DetailView = class {
|
|
885
|
-
constructor(opts) {
|
|
886
|
-
this.calcResolution = null;
|
|
887
|
-
/** Defaults **/
|
|
888
|
-
this.binpx = 2;
|
|
889
|
-
this.bbmargin = 1;
|
|
890
|
-
this.app = opts.app;
|
|
891
|
-
this.hic = opts.hic;
|
|
892
|
-
this.plotDiv = opts.plotDiv;
|
|
893
|
-
this.sheath = opts.plotDiv.yAxis.append("div").style("position", "relative").style("width", "200px").style("height", "800px");
|
|
894
|
-
this.rotor = this.sheath.append("div").style("position", "absolute").style("bottom", "0px").style("transform", "rotate(-90deg)").style("transform-origin", "left bottom");
|
|
895
|
-
this.data = opts.data;
|
|
896
|
-
this.parent = opts.parent;
|
|
897
|
-
this.errList = this.parent("errList");
|
|
898
|
-
this.resolution = new Resolution(opts.error);
|
|
899
|
-
this.colorizeElement = new ColorizeElement();
|
|
900
|
-
this.viewRangeBpW = this.resolution.getDefaultViewSpan(
|
|
901
|
-
this.hic,
|
|
902
|
-
this.parent("state").x,
|
|
903
|
-
this.parent("state").y,
|
|
904
|
-
this.parent("state").initialBinNum,
|
|
905
|
-
this.parent("state").minBinNum_bp
|
|
906
|
-
);
|
|
907
|
-
this.dataMapper = new DetailDataMapper(this.hic, opts.error, opts.parent);
|
|
908
|
-
this.coordinates = new DetailCoordinates(this.hic, this.errList);
|
|
909
|
-
}
|
|
910
|
-
renderCanvas(blockwidth) {
|
|
911
|
-
this.canvasHolder = this.plotDiv.plot.append("div").style("position", "relative").style("width", `${this.xBlock.bbw}px`).style("height", `${this.yBlock.bbw}px`).style("overflow", "hidden");
|
|
912
|
-
this.canvas = this.canvasHolder.append("canvas").style("display", "block").style("position", "absolute").attr("data-testid", "sjpp-hic-detail-canvas").attr("width", blockwidth).attr("height", blockwidth).on("mousedown", (event) => {
|
|
913
|
-
const body = select_default(document.body);
|
|
914
|
-
const x = event.clientX;
|
|
915
|
-
const y = event.clientY;
|
|
916
|
-
const oldx = Number.parseInt(this.canvas.style("left"));
|
|
917
|
-
const oldy = Number.parseInt(this.canvas.style("top"));
|
|
918
|
-
body.on("mousemove", (event2) => {
|
|
919
|
-
const xoff = event2.clientX - x;
|
|
920
|
-
const yoff = event2.clientY - y;
|
|
921
|
-
this.xBlock.block.panning(xoff);
|
|
922
|
-
this.yBlock.block.panning(yoff);
|
|
923
|
-
this.canvas.style("left", `${oldx + xoff}px`).style("top", `${oldy + yoff}px`);
|
|
924
|
-
});
|
|
925
|
-
body.on("mouseup", (event2) => {
|
|
926
|
-
body.on("mousemove", null).on("mouseup", null);
|
|
927
|
-
const xoff = event2.clientX - x;
|
|
928
|
-
const yoff = event2.clientY - y;
|
|
929
|
-
this.xBlock.block.pannedby(xoff);
|
|
930
|
-
this.yBlock.block.pannedby(yoff);
|
|
931
|
-
});
|
|
932
|
-
});
|
|
933
|
-
}
|
|
934
|
-
async render() {
|
|
935
|
-
this.calcResolution = this.parent("calcResolution");
|
|
936
|
-
const state = this.parent("state");
|
|
937
|
-
this.xBlock = new DetailBlock(
|
|
938
|
-
this.app,
|
|
939
|
-
this.hic,
|
|
940
|
-
state.settings.widthHeightPx,
|
|
941
|
-
this.bbmargin,
|
|
942
|
-
this.plotDiv.xAxis,
|
|
943
|
-
false
|
|
944
|
-
);
|
|
945
|
-
this.yBlock = new DetailBlock(this.app, this.hic, state.settings.widthHeightPx, this.bbmargin, this.rotor, true);
|
|
946
|
-
this.renderCanvas(state.settings.widthHeightPx);
|
|
947
|
-
await this.xBlock.loadBlock(state.x, this.canvasHolder, this.canvas);
|
|
948
|
-
await this.yBlock.loadBlock(state.y, this.canvasHolder, this.canvas, this.sheath);
|
|
949
|
-
this.update(this.data);
|
|
950
|
-
}
|
|
951
|
-
async update(data) {
|
|
952
|
-
if (data.items.length == 0) {
|
|
953
|
-
this.app.dispatch({ type: "loading_active", active: false });
|
|
954
|
-
return;
|
|
955
|
-
}
|
|
956
|
-
this.data = data;
|
|
957
|
-
const state = this.parent("state");
|
|
958
|
-
const initialWidth = Number.parseInt(this.canvas.attr("width"));
|
|
959
|
-
const holderChange = Number.parseInt(this.canvasHolder.style("width")) - initialWidth + state.settings.widthHeightPx;
|
|
960
|
-
this.canvasHolder.style("width", `${holderChange}px`).style("height", `${holderChange}px`);
|
|
961
|
-
this.canvas.attr("width", `${state.settings.widthHeightPx}px`).attr("height", `${state.settings.widthHeightPx}px`);
|
|
962
|
-
if (this.xBlock.block.width != state.settings.widthHeightPx) {
|
|
963
|
-
this.xBlock.block.width = state.settings.widthHeightPx;
|
|
964
|
-
this.yBlock.block.width = state.settings.widthHeightPx;
|
|
965
|
-
this.xBlock.block.zoom2px(0, initialWidth);
|
|
966
|
-
this.yBlock.block.zoom2px(0, initialWidth);
|
|
967
|
-
}
|
|
968
|
-
this.ctx = this.canvas.node().getContext("2d");
|
|
969
|
-
const coords = this.coordinates.getCoordinates(
|
|
970
|
-
state.x,
|
|
971
|
-
state.y,
|
|
972
|
-
this.parent("data"),
|
|
973
|
-
this.parent("calcResolution"),
|
|
974
|
-
state.settings.widthHeightPx,
|
|
975
|
-
this.parent("fragData")
|
|
976
|
-
);
|
|
977
|
-
this.coords = coords;
|
|
978
|
-
this.ctx.clearRect(0, 0, state.settings.widthHeightPx, state.settings.widthHeightPx);
|
|
979
|
-
for (const [xCoord, yCoord, width, height, value] of this.coords) {
|
|
980
|
-
this.colorizeElement.colorizeElement(
|
|
981
|
-
xCoord,
|
|
982
|
-
yCoord,
|
|
983
|
-
value,
|
|
984
|
-
this.ctx,
|
|
985
|
-
width,
|
|
986
|
-
height,
|
|
987
|
-
this.parent("min"),
|
|
988
|
-
this.parent("max"),
|
|
989
|
-
"detail"
|
|
990
|
-
);
|
|
991
|
-
}
|
|
992
|
-
this.app.dispatch({ type: "loading_active", active: false });
|
|
993
|
-
}
|
|
994
|
-
};
|
|
995
|
-
|
|
996
|
-
// tracks/hic/axes/Chromosome.ts
|
|
997
|
-
var Chromosome = class {
|
|
998
|
-
constructor(chr, width) {
|
|
999
|
-
this.label = chr;
|
|
1000
|
-
this.width = width;
|
|
1001
|
-
}
|
|
1002
|
-
};
|
|
1003
|
-
|
|
1004
|
-
// tracks/hic/grid/Grid.ts
|
|
1005
|
-
var Grid = class _Grid {
|
|
1006
|
-
constructor(chrlst, resolution, chrlookup, binpx) {
|
|
1007
|
-
this.chromosomeMatrix = /* @__PURE__ */ new Map();
|
|
1008
|
-
this.chromosomeList = [];
|
|
1009
|
-
this.xoff = 0;
|
|
1010
|
-
this.yoff = 0;
|
|
1011
|
-
this.chr2px = [];
|
|
1012
|
-
this.chrlst = chrlst;
|
|
1013
|
-
let totalpx = this.chrlst.length;
|
|
1014
|
-
for (const chr of this.chrlst) {
|
|
1015
|
-
const w = Math.ceil(chrlookup[chr.toUpperCase()].len / resolution) * binpx;
|
|
1016
|
-
const chromosome = new Chromosome(chr, w);
|
|
1017
|
-
this.chromosomeList.push(chromosome);
|
|
1018
|
-
this.chr2px[chr] = w;
|
|
1019
|
-
totalpx += w;
|
|
1020
|
-
}
|
|
1021
|
-
this.totalpx = totalpx;
|
|
1022
|
-
for (let i = 0; i < this.chrlst.length; i++) {
|
|
1023
|
-
const chrx = this.chrlst[i];
|
|
1024
|
-
this.chromosomeMatrix.set(chrx, /* @__PURE__ */ new Map());
|
|
1025
|
-
let yoff = 0;
|
|
1026
|
-
for (let j = 0; j <= i; j++) {
|
|
1027
|
-
const chry = this.chrlst[j];
|
|
1028
|
-
const chrxChrLen = chrlookup[chrx.toUpperCase()].len;
|
|
1029
|
-
const chryChrLen = chrlookup[chry.toUpperCase()].len;
|
|
1030
|
-
const xbins = Math.ceil(chrxChrLen / resolution) * binpx;
|
|
1031
|
-
const ybins = Math.ceil(chryChrLen / resolution) * binpx;
|
|
1032
|
-
this.chromosomeMatrix.get(chrx).set(chry, {
|
|
1033
|
-
x: this.xoff,
|
|
1034
|
-
y: yoff,
|
|
1035
|
-
xbins,
|
|
1036
|
-
ybins,
|
|
1037
|
-
data: []
|
|
1038
|
-
//Empty array of data to fill later
|
|
1039
|
-
});
|
|
1040
|
-
yoff += this.chr2px[chry] + _Grid.borderWidth;
|
|
1041
|
-
}
|
|
1042
|
-
this.yoff = yoff;
|
|
1043
|
-
this.xoff += this.chr2px[chrx] + _Grid.borderWidth;
|
|
1044
|
-
}
|
|
1045
|
-
}
|
|
1046
|
-
static {
|
|
1047
|
-
this.checkerFill = "#DEF3FA";
|
|
1048
|
-
}
|
|
1049
|
-
static {
|
|
1050
|
-
this.spaceColor = "#CCC";
|
|
1051
|
-
}
|
|
1052
|
-
static {
|
|
1053
|
-
this.fontSize = 15;
|
|
1054
|
-
}
|
|
1055
|
-
static {
|
|
1056
|
-
this.font = font;
|
|
1057
|
-
}
|
|
1058
|
-
static {
|
|
1059
|
-
this.borderWidth = 1;
|
|
1060
|
-
}
|
|
1061
|
-
static {
|
|
1062
|
-
this.defaultChrLabWidth = 100;
|
|
1063
|
-
}
|
|
1064
|
-
};
|
|
1065
|
-
|
|
1066
|
-
// tracks/hic/viewmodel/GridViewModel.ts
|
|
1067
|
-
var GridViewModel = class {
|
|
1068
|
-
constructor(opts) {
|
|
1069
|
-
this.grid = new Grid(opts.hic.chrlst, opts.resolution || opts.hic.bpresolution[0], opts.hic.genome.chrlookup, 1);
|
|
1070
|
-
}
|
|
1071
|
-
};
|
|
1072
|
-
|
|
1073
|
-
// tracks/hic/grid/GridRenderer.ts
|
|
1074
|
-
var GridRenderer = class {
|
|
1075
|
-
constructor(svg, layerMap, layerSv, grid) {
|
|
1076
|
-
this.svg = svg;
|
|
1077
|
-
this.layerMap = layerMap.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
|
|
1078
|
-
this.layerSv = layerSv.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
|
|
1079
|
-
this.grid = grid;
|
|
1080
|
-
}
|
|
1081
|
-
render() {
|
|
1082
|
-
this.renderAxisX(this.grid);
|
|
1083
|
-
this.renderAxisY(this.grid);
|
|
1084
|
-
this.svg.attr("width", Grid.defaultChrLabWidth + this.grid.xoff).attr("height", Grid.fontSize + this.grid.yoff);
|
|
1085
|
-
}
|
|
1086
|
-
renderAxisX(grid) {
|
|
1087
|
-
let xoff = 0;
|
|
1088
|
-
this.grid.chromosomeList.forEach((chr, index) => {
|
|
1089
|
-
const chrw = chr.width;
|
|
1090
|
-
if (index % 2 === 0) {
|
|
1091
|
-
this.layerMap.append("rect").attr("x", xoff).attr("width", chrw).attr("height", Grid.fontSize).attr("y", -Grid.fontSize).attr("fill", Grid.checkerFill);
|
|
1092
|
-
}
|
|
1093
|
-
this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-xAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "middle").attr("font-size", 12).attr("x", xoff + chrw / 2).text(chr.label);
|
|
1094
|
-
xoff += chrw;
|
|
1095
|
-
this.layerSv.append("line").attr("x1", xoff).attr("x2", xoff).attr("y2", grid.totalpx).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
|
|
1096
|
-
xoff += Grid.borderWidth;
|
|
1097
|
-
});
|
|
1098
|
-
}
|
|
1099
|
-
renderAxisY(grid) {
|
|
1100
|
-
let yoff = 0;
|
|
1101
|
-
this.grid.chromosomeList.forEach((chr, index) => {
|
|
1102
|
-
const chrh = chr.width;
|
|
1103
|
-
if (index % 2 === 0) {
|
|
1104
|
-
this.layerMap.append("rect").attr("x", -Grid.defaultChrLabWidth).attr("width", Grid.defaultChrLabWidth).attr("height", chrh).attr("y", yoff).attr("fill", Grid.checkerFill);
|
|
1105
|
-
}
|
|
1106
|
-
this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-yAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "end").attr("dominant-baseline", "central").attr("font-size", 12).attr("y", yoff + chrh / 2).text(chr.label);
|
|
1107
|
-
yoff += chrh;
|
|
1108
|
-
this.layerSv.append("line").attr("x2", grid.totalpx).attr("y1", yoff).attr("y2", yoff).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
|
|
1109
|
-
yoff += Grid.borderWidth;
|
|
1110
|
-
});
|
|
1111
|
-
}
|
|
1112
|
-
};
|
|
1113
|
-
|
|
1114
|
-
// tracks/hic/genome/ChrsTooltips.ts
|
|
1115
|
-
var ChrsTooltips = class {
|
|
1116
|
-
constructor() {
|
|
1117
|
-
this.chrx_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
|
|
1118
|
-
this.chry_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
|
|
1119
|
-
}
|
|
1120
|
-
render(img, chrx, chry) {
|
|
1121
|
-
const p = img.node().getBoundingClientRect();
|
|
1122
|
-
this.chrx_tip.clear().show(p.left, p.top).d.style("top", null).attr("data-testid", "sjpp-hic-chrx-tooltip").style("bottom", window.innerHeight - p.top - window.pageYOffset + "px").text(chrx);
|
|
1123
|
-
this.chry_tip.clear().show(p.left, p.top).d.style("left", null).attr("data-testid", "sjpp-hic-chry-tooltip").style("right", document.body.clientWidth - p.left - window.pageXOffset + "px").text(chry);
|
|
1124
|
-
}
|
|
1125
|
-
};
|
|
1126
|
-
|
|
1127
|
-
// tracks/hic/grid/GridElementRenderer.ts
|
|
1128
|
-
var GridElementRenderer = class {
|
|
1129
|
-
constructor(layerMap, app) {
|
|
1130
|
-
this.app = app;
|
|
1131
|
-
this.layerMap = layerMap;
|
|
1132
|
-
this.tooltips = new ChrsTooltips();
|
|
1133
|
-
}
|
|
1134
|
-
render(obj, lead, follow, holder) {
|
|
1135
|
-
obj.canvas = holder.append("canvas").style("display", "none").node();
|
|
1136
|
-
obj.ctx = obj.canvas.getContext("2d");
|
|
1137
|
-
obj.canvas.width = obj.xbins;
|
|
1138
|
-
obj.canvas.height = obj.ybins;
|
|
1139
|
-
obj.img = this.layerMap.append("image").attr("width", obj.canvas.width).attr("height", obj.canvas.height).attr("x", obj.x).attr("y", obj.y).on("click", async () => {
|
|
1140
|
-
await this.app.dispatch({
|
|
1141
|
-
type: "view_create",
|
|
1142
|
-
view: "chrpair",
|
|
1143
|
-
config: {
|
|
1144
|
-
x: {
|
|
1145
|
-
chr: lead
|
|
1146
|
-
},
|
|
1147
|
-
y: {
|
|
1148
|
-
chr: follow
|
|
1149
|
-
}
|
|
1150
|
-
}
|
|
1151
|
-
});
|
|
1152
|
-
}).on("mouseover", () => {
|
|
1153
|
-
this.tooltips.render(obj.img, lead, follow);
|
|
1154
|
-
});
|
|
1155
|
-
if (lead != follow) {
|
|
1156
|
-
obj.canvas2 = holder.append("canvas").style("display", "none").node();
|
|
1157
|
-
obj.canvas2.width = obj.ybins;
|
|
1158
|
-
obj.canvas2.height = obj.xbins;
|
|
1159
|
-
obj.ctx2 = obj.canvas2.getContext("2d");
|
|
1160
|
-
obj.img2 = this.layerMap.append("image").attr("width", obj.canvas2.width).attr("height", obj.canvas2.height).attr("x", obj.y).attr("y", obj.x).on("click", async () => {
|
|
1161
|
-
await this.app.dispatch({
|
|
1162
|
-
type: "view_create",
|
|
1163
|
-
view: "chrpair",
|
|
1164
|
-
config: {
|
|
1165
|
-
x: {
|
|
1166
|
-
chr: follow
|
|
1167
|
-
},
|
|
1168
|
-
y: {
|
|
1169
|
-
chr: lead
|
|
1170
|
-
}
|
|
1171
|
-
}
|
|
1172
|
-
});
|
|
1173
|
-
}).on("mouseover", () => {
|
|
1174
|
-
this.tooltips.render(obj.img2, follow, lead);
|
|
1175
|
-
});
|
|
1176
|
-
} else {
|
|
1177
|
-
obj.ctx2 = obj.ctx;
|
|
1178
|
-
}
|
|
1179
|
-
}
|
|
1180
|
-
};
|
|
1181
|
-
|
|
1182
|
-
// tracks/hic/grid/GridElementsRenderer.ts
|
|
1183
|
-
var GridElementsRenderer = class {
|
|
1184
|
-
constructor(grid, layerMap, app) {
|
|
1185
|
-
this.grid = grid;
|
|
1186
|
-
this.gridElementRenderer = new GridElementRenderer(layerMap, app);
|
|
1187
|
-
}
|
|
1188
|
-
render(holder) {
|
|
1189
|
-
for (const [chrx, chryMap] of this.grid.chromosomeMatrix) {
|
|
1190
|
-
for (const [chry, gridElem] of chryMap) {
|
|
1191
|
-
this.gridElementRenderer.render(gridElem, chrx, chry, holder);
|
|
1192
|
-
}
|
|
1193
|
-
}
|
|
1194
|
-
}
|
|
1195
|
-
};
|
|
1196
|
-
|
|
1197
|
-
// tracks/hic/genome/GenomeView.ts
|
|
1198
|
-
var GenomeView = class {
|
|
1199
|
-
constructor(opts) {
|
|
1200
|
-
/** Dom */
|
|
1201
|
-
this.tip = new Menu();
|
|
1202
|
-
this.pica_x = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
|
|
1203
|
-
this.pica_y = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
|
|
1204
|
-
/** Data */
|
|
1205
|
-
/** px width for each chr */
|
|
1206
|
-
this.chr2px = {};
|
|
1207
|
-
this.lead2follow = /* @__PURE__ */ new Map();
|
|
1208
|
-
this.values = [];
|
|
1209
|
-
/** Defaults */
|
|
1210
|
-
this.defaultChrLabWidth = 100;
|
|
1211
|
-
this.borderwidth = 1;
|
|
1212
|
-
this.default_maxVPerc = 5;
|
|
1213
|
-
this.fontsize = 15;
|
|
1214
|
-
this.xoff = 0;
|
|
1215
|
-
this.yoff = 0;
|
|
1216
|
-
this.binpx = 1;
|
|
1217
|
-
this.atdev_chrnum = 8;
|
|
1218
|
-
this.min = 0;
|
|
1219
|
-
this.max = 0;
|
|
1220
|
-
this.app = opts.app;
|
|
1221
|
-
this.hic = opts.hic;
|
|
1222
|
-
this.plotDiv = opts.plotDiv;
|
|
1223
|
-
this.data = opts.data;
|
|
1224
|
-
this.parent = opts.parent;
|
|
1225
|
-
this.resolution = opts.resolution || opts.hic.bpresolution[0];
|
|
1226
|
-
this.svg = this.plotDiv.plot.append("svg").attr("data-testid", "sjpp-hic-genome-svg");
|
|
1227
|
-
this.layer_map = this.svg.append("g").attr("data-testid", "sjpp-hic-layerMap-g");
|
|
1228
|
-
this.layer_sv = this.svg.append("g").attr("data-testid", "sjpp-hic-layerSv-g");
|
|
1229
|
-
this.colorizeElement = new ColorizeElement();
|
|
1230
|
-
this.viewModel = new GridViewModel(opts);
|
|
1231
|
-
this.viewRender = new GridRenderer(this.svg, this.layer_map, this.layer_sv, this.viewModel.grid);
|
|
1232
|
-
this.gridElementsRenderer = new GridElementsRenderer(this.viewModel.grid, this.layer_map, this.app);
|
|
1233
|
-
this.gridFormattedData = new GridElementsFormattedData();
|
|
1234
|
-
}
|
|
1235
|
-
makeSv() {
|
|
1236
|
-
const unknownchr = /* @__PURE__ */ new Set();
|
|
1237
|
-
const radius = 8;
|
|
1238
|
-
for (const item of this.hic.sv.items) {
|
|
1239
|
-
const _o = this.lead2follow.get(item.chr1);
|
|
1240
|
-
if (!_o) {
|
|
1241
|
-
unknownchr.add(item.chr1);
|
|
1242
|
-
continue;
|
|
1243
|
-
}
|
|
1244
|
-
const obj = _o.get(item.chr2);
|
|
1245
|
-
if (!obj) {
|
|
1246
|
-
unknownchr.add(item.chr2);
|
|
1247
|
-
continue;
|
|
1248
|
-
}
|
|
1249
|
-
const p1 = item.position1 / this.resolution;
|
|
1250
|
-
const p2 = item.position2 / this.resolution;
|
|
1251
|
-
this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cx", obj.x + p1).attr("cy", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
|
|
1252
|
-
this.tooltipSv(event, item);
|
|
1253
|
-
}).on("mouseout", () => {
|
|
1254
|
-
this.tip.hide();
|
|
1255
|
-
}).on("click", () => {
|
|
1256
|
-
this.clickSv(item);
|
|
1257
|
-
});
|
|
1258
|
-
if (obj.img2) {
|
|
1259
|
-
this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle-2").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cy", obj.x + p1).attr("cx", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
|
|
1260
|
-
this.tooltipSv(event, item);
|
|
1261
|
-
}).on("mouseout", () => {
|
|
1262
|
-
this.tip.hide();
|
|
1263
|
-
}).on("click", () => {
|
|
1264
|
-
this.clickSv(item);
|
|
1265
|
-
});
|
|
1266
|
-
}
|
|
1267
|
-
}
|
|
1268
|
-
}
|
|
1269
|
-
tooltipSv(event, item) {
|
|
1270
|
-
this.tip.clear().show(event.clientX, event.clientY).d.append("div").text(
|
|
1271
|
-
item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`
|
|
1272
|
-
);
|
|
1273
|
-
}
|
|
1274
|
-
clickSv(item) {
|
|
1275
|
-
const default_svpointspan = 5e5;
|
|
1276
|
-
const default_subpanelpxwidth = 600;
|
|
1277
|
-
const subpanel_bordercolor = "rgba(200,0,0,.1)";
|
|
1278
|
-
const pane = newpane({ x: 100, y: 100 });
|
|
1279
|
-
pane.header.text(
|
|
1280
|
-
this.hic.name + " " + (item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`)
|
|
1281
|
-
);
|
|
1282
|
-
const tracks = [
|
|
1283
|
-
{
|
|
1284
|
-
type: tkt.hicstraw,
|
|
1285
|
-
file: this.hic.file,
|
|
1286
|
-
enzyme: this.hic.enzyme,
|
|
1287
|
-
maxpercentage: this.default_maxVPerc,
|
|
1288
|
-
pyramidup: 1,
|
|
1289
|
-
name: this.hic.name
|
|
1290
|
-
}
|
|
1291
|
-
];
|
|
1292
|
-
if (this.hic.tklst) {
|
|
1293
|
-
for (const t of this.hic.tklst) {
|
|
1294
|
-
tracks.push(t);
|
|
1295
|
-
}
|
|
1296
|
-
}
|
|
1297
|
-
first_genetrack_tolist(this.hic.genome, tracks);
|
|
1298
|
-
const arg = {
|
|
1299
|
-
holder: pane.body,
|
|
1300
|
-
hostURL: this.hic.hostURL,
|
|
1301
|
-
jwt: this.hic.jwt,
|
|
1302
|
-
genome: this.hic.genome,
|
|
1303
|
-
nobox: 1,
|
|
1304
|
-
tklst: tracks
|
|
1305
|
-
};
|
|
1306
|
-
if (item.chr1 == item.chr2 && Math.abs(item.position2 - item.position1) < default_svpointspan * 2) {
|
|
1307
|
-
arg.chr = item.chr1;
|
|
1308
|
-
const w = Math.abs(item.position2 - item.position1);
|
|
1309
|
-
arg.start = Math.max(1, Math.min(item.position1, item.position2) - w);
|
|
1310
|
-
arg.stop = Math.min(
|
|
1311
|
-
this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
|
|
1312
|
-
Math.max(item.position1, item.position2) + w
|
|
1313
|
-
);
|
|
1314
|
-
} else {
|
|
1315
|
-
arg.chr = item.chr1;
|
|
1316
|
-
arg.start = Math.max(1, item.position1 - default_svpointspan / 2);
|
|
1317
|
-
arg.stop = Math.min(
|
|
1318
|
-
this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
|
|
1319
|
-
item.position1 + default_svpointspan / 2
|
|
1320
|
-
);
|
|
1321
|
-
arg.width = default_subpanelpxwidth;
|
|
1322
|
-
arg.subpanels = [
|
|
1323
|
-
{
|
|
1324
|
-
chr: item.chr2,
|
|
1325
|
-
start: Math.max(1, item.position2 - default_svpointspan / 2),
|
|
1326
|
-
stop: Math.min(
|
|
1327
|
-
this.hic.genome.chrlookup[item.chr2.toUpperCase()].len,
|
|
1328
|
-
item.position2 + default_svpointspan / 2
|
|
1329
|
-
),
|
|
1330
|
-
width: default_subpanelpxwidth,
|
|
1331
|
-
leftpad: 10,
|
|
1332
|
-
leftborder: subpanel_bordercolor
|
|
1333
|
-
}
|
|
1334
|
-
];
|
|
1335
|
-
}
|
|
1336
|
-
blocklazyload(arg);
|
|
1337
|
-
}
|
|
1338
|
-
render() {
|
|
1339
|
-
this.viewRender.render();
|
|
1340
|
-
this.gridElementsRenderer.render(this.hic.holder);
|
|
1341
|
-
if (this.hic.sv && this.hic.sv.items) {
|
|
1342
|
-
this.makeSv();
|
|
1343
|
-
}
|
|
1344
|
-
this.update(this.data);
|
|
1345
|
-
}
|
|
1346
|
-
update(data) {
|
|
1347
|
-
this.data = data;
|
|
1348
|
-
this.min = this.parent("min");
|
|
1349
|
-
this.max = this.parent("max");
|
|
1350
|
-
for (const data2 of this.data) {
|
|
1351
|
-
if (!this.hic.chrlst.includes(data2.lead) || !this.hic.chrlst.includes(data2.follow)) continue;
|
|
1352
|
-
const obj = this.viewModel.grid.chromosomeMatrix.get(data2.lead).get(data2.follow);
|
|
1353
|
-
if (!obj) continue;
|
|
1354
|
-
obj.ctx.clearRect(0, 0, obj.canvas.width, obj.canvas.height);
|
|
1355
|
-
if (obj.canvas2) {
|
|
1356
|
-
obj.ctx2.clearRect(0, 0, obj.canvas2.width, obj.canvas.height);
|
|
1357
|
-
}
|
|
1358
|
-
obj.data = this.gridFormattedData.formatData("genome", data2.items, this.binpx, this.resolution);
|
|
1359
|
-
for (const [xPx, yPx, value] of obj.data) {
|
|
1360
|
-
this.colorizeElement.colorizeElement(xPx, yPx, value, obj, this.binpx, this.binpx, this.min, this.max, "genome");
|
|
1361
|
-
}
|
|
1362
|
-
obj.img.attr("xlink:href", obj.canvas.toDataURL());
|
|
1363
|
-
if (obj.canvas2) {
|
|
1364
|
-
obj.img2.attr("xlink:href", obj.canvas2.toDataURL());
|
|
1365
|
-
}
|
|
1366
|
-
}
|
|
1367
|
-
this.app.dispatch({ type: "loading_active", active: false });
|
|
1368
|
-
}
|
|
1369
|
-
};
|
|
1370
|
-
|
|
1371
|
-
// tracks/hic/controls/NormalizationMethodControl.ts
|
|
1372
|
-
var NormalizationMethodControl = class {
|
|
1373
|
-
constructor(holder, normalization, defaultNmeth, callback) {
|
|
1374
|
-
this.holder = holder;
|
|
1375
|
-
this.normalization = normalization;
|
|
1376
|
-
this.defaultNmeth = defaultNmeth;
|
|
1377
|
-
this.callback = callback;
|
|
1378
|
-
}
|
|
1379
|
-
render() {
|
|
1380
|
-
if (!this.normalization?.length) {
|
|
1381
|
-
this.nmethSelect = this.holder.text(this.defaultNmeth);
|
|
1382
|
-
} else {
|
|
1383
|
-
this.nmethSelect = this.holder.attr("data-testid", "sjpp-hic-nmeth-select").style("margin-right", "10px").append("select").on("change", async () => {
|
|
1384
|
-
const nmeth = this.nmethSelect.node().value;
|
|
1385
|
-
this.callback(nmeth, "nmeth");
|
|
1386
|
-
});
|
|
1387
|
-
for (const n of this.normalization) {
|
|
1388
|
-
this.nmethSelect.append("option").text(n);
|
|
1389
|
-
}
|
|
1390
|
-
}
|
|
1391
|
-
}
|
|
1392
|
-
update(option) {
|
|
1393
|
-
const options = this.nmethSelect.node().options;
|
|
1394
|
-
if (!options) return;
|
|
1395
|
-
const selectedNmeth = Array.from(options).find((o) => o.value === option);
|
|
1396
|
-
if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
|
|
1397
|
-
selectedNmeth.selected = true;
|
|
1398
|
-
}
|
|
1399
|
-
};
|
|
1400
|
-
|
|
1401
|
-
// tracks/hic/controls/CutoffControl.ts
|
|
1402
|
-
var CutoffControl = class {
|
|
1403
|
-
constructor(holder, value, callback) {
|
|
1404
|
-
this.holder = holder;
|
|
1405
|
-
this.value = value;
|
|
1406
|
-
this.callback = callback;
|
|
1407
|
-
}
|
|
1408
|
-
render(opts) {
|
|
1409
|
-
const cutoffDiv = this.holder.attr("data-testid", "sjpp-hic-cutoff-control").style("margin-right", "10px").append("input").attr("type", "number").style("width", opts && "width" in opts ? opts.width : "80px").style("margin-left", "0px").attr("type", "number").property("value", this.value).on("keyup", async (event) => {
|
|
1410
|
-
if (event.code != "Enter") return;
|
|
1411
|
-
const v = event.target.value;
|
|
1412
|
-
this.callback(v);
|
|
1413
|
-
});
|
|
1414
|
-
return cutoffDiv;
|
|
1415
|
-
}
|
|
1416
|
-
};
|
|
1417
|
-
|
|
1418
|
-
// tracks/hic/controls/MatrixTypeControl.ts
|
|
1419
|
-
var MatrixTypeControl = class {
|
|
1420
|
-
constructor(holder, callback) {
|
|
1421
|
-
this.values = [
|
|
1422
|
-
{ label: "Observed", value: "observed" },
|
|
1423
|
-
{ label: "Expected", value: "expected" },
|
|
1424
|
-
{ label: "Observed/Expected", value: "oe" },
|
|
1425
|
-
{ label: "Log(Observed/Expected)", value: "log(oe)" }
|
|
1426
|
-
// TODO: add server side logic to support these options
|
|
1427
|
-
// { label: 'Log(Observed + 1)', value: 'log(obs+1)'},
|
|
1428
|
-
// { label: 'Observed Pearson', value: 'op'}
|
|
1429
|
-
];
|
|
1430
|
-
this.holder = holder;
|
|
1431
|
-
this.callback = callback;
|
|
1432
|
-
}
|
|
1433
|
-
render() {
|
|
1434
|
-
this.matrixSelect = this.holder.attr("data-testid", "sjpp-hic-matrix-type-select").style("margin-right", "10px").append("select").on("change", async () => {
|
|
1435
|
-
this.callback(this.matrixSelect.node().value, "matrixType");
|
|
1436
|
-
});
|
|
1437
|
-
for (const matrixType of this.values) {
|
|
1438
|
-
this.matrixSelect.append("option").text(matrixType.label).attr("value", matrixType.value);
|
|
1439
|
-
}
|
|
1440
|
-
}
|
|
1441
|
-
update(option) {
|
|
1442
|
-
const options = this.matrixSelect.node().options;
|
|
1443
|
-
if (!options) return;
|
|
1444
|
-
const selectedNmeth = Array.from(options).find((o) => o.value === option);
|
|
1445
|
-
if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
|
|
1446
|
-
selectedNmeth.selected = true;
|
|
1447
|
-
}
|
|
1448
|
-
};
|
|
1449
|
-
|
|
1450
|
-
// tracks/hic/controls/ControlPanel.ts
|
|
1451
|
-
var ControlPanel = class _ControlPanel {
|
|
1452
|
-
constructor(opts) {
|
|
1453
|
-
this.zoomBlockCallback = (bool) => {
|
|
1454
|
-
const detailView = this.parent("detail");
|
|
1455
|
-
detailView.xBlock.block.zoomblock(2, bool);
|
|
1456
|
-
detailView.yBlock.block.zoomblock(2, bool);
|
|
1457
|
-
};
|
|
1458
|
-
this.minCallback = (v) => {
|
|
1459
|
-
if (Number(v) > Number(this.parent("max"))) {
|
|
1460
|
-
this.error("Min cutoff cannot be greater than max cutoff");
|
|
1461
|
-
} else {
|
|
1462
|
-
this.parent("min", Number(v));
|
|
1463
|
-
this.reColorHeatmap();
|
|
1464
|
-
this.parent("infoBar").update();
|
|
1465
|
-
}
|
|
1466
|
-
};
|
|
1467
|
-
this.maxCallback = (v) => {
|
|
1468
|
-
if (Number(v) < Number(this.parent("min"))) {
|
|
1469
|
-
this.error(`Max cutoff cannot be less than min cutoff`);
|
|
1470
|
-
} else if (Number(v) < 0) {
|
|
1471
|
-
this.error(`Max cutoff cannot be less than 0`);
|
|
1472
|
-
} else {
|
|
1473
|
-
this.parent("max", Number(v));
|
|
1474
|
-
this.reColorHeatmap();
|
|
1475
|
-
this.parent("infoBar").update();
|
|
1476
|
-
}
|
|
1477
|
-
};
|
|
1478
|
-
this.reColorHeatmap = () => {
|
|
1479
|
-
if (this.parent("activeView") == "genome") {
|
|
1480
|
-
const genomeView = this.parent("genome");
|
|
1481
|
-
const chrMatrix = genomeView.viewRender.grid.chromosomeMatrix;
|
|
1482
|
-
if (!chrMatrix) return;
|
|
1483
|
-
for (const map of chrMatrix) {
|
|
1484
|
-
const yMap = map[1];
|
|
1485
|
-
for (const obj of yMap) {
|
|
1486
|
-
const canvasObj = obj[1];
|
|
1487
|
-
if (!canvasObj) continue;
|
|
1488
|
-
for (const [leadpx, followpx, val] of canvasObj.data) {
|
|
1489
|
-
this.colorizeElement.colorizeElement(
|
|
1490
|
-
leadpx,
|
|
1491
|
-
followpx,
|
|
1492
|
-
val,
|
|
1493
|
-
canvasObj,
|
|
1494
|
-
1,
|
|
1495
|
-
1,
|
|
1496
|
-
this.parent("min"),
|
|
1497
|
-
this.parent("max"),
|
|
1498
|
-
"genome"
|
|
1499
|
-
);
|
|
1500
|
-
}
|
|
1501
|
-
canvasObj.img.attr("xlink:href", canvasObj.canvas.toDataURL());
|
|
1502
|
-
if (canvasObj.canvas2) {
|
|
1503
|
-
canvasObj.img2.attr("xlink:href", canvasObj.canvas2.toDataURL());
|
|
1504
|
-
}
|
|
1505
|
-
}
|
|
1506
|
-
}
|
|
1507
|
-
} else if (this.parent("activeView") == "chrpair") {
|
|
1508
|
-
const view = this.parent("chrpair");
|
|
1509
|
-
for (const [xCoord, yCoord, val] of view.data) {
|
|
1510
|
-
this.colorizeElement.colorizeElement(
|
|
1511
|
-
xCoord,
|
|
1512
|
-
yCoord,
|
|
1513
|
-
val,
|
|
1514
|
-
view.ctx,
|
|
1515
|
-
view.binpx,
|
|
1516
|
-
view.binpx,
|
|
1517
|
-
this.parent("min"),
|
|
1518
|
-
this.parent("max"),
|
|
1519
|
-
"chrpair"
|
|
1520
|
-
);
|
|
1521
|
-
}
|
|
1522
|
-
} else if (this.parent("activeView") == "detail") {
|
|
1523
|
-
const view = this.parent("detail");
|
|
1524
|
-
for (const [xCoord, yCoord, width, height, value] of view.coords) {
|
|
1525
|
-
this.colorizeElement.colorizeElement(
|
|
1526
|
-
xCoord,
|
|
1527
|
-
yCoord,
|
|
1528
|
-
value,
|
|
1529
|
-
view.ctx,
|
|
1530
|
-
width,
|
|
1531
|
-
height,
|
|
1532
|
-
this.parent("min"),
|
|
1533
|
-
this.parent("max"),
|
|
1534
|
-
"detail"
|
|
1535
|
-
);
|
|
1536
|
-
}
|
|
1537
|
-
}
|
|
1538
|
-
};
|
|
1539
|
-
this.dropdownCallback = (v, prop) => {
|
|
1540
|
-
const state = this.app.getState();
|
|
1541
|
-
this.app.dispatch({
|
|
1542
|
-
type: "view_update",
|
|
1543
|
-
view: state.currView,
|
|
1544
|
-
config: { [prop]: v }
|
|
1545
|
-
});
|
|
1546
|
-
};
|
|
1547
|
-
this.type = _ControlPanel.type;
|
|
1548
|
-
this.controls = {};
|
|
1549
|
-
this.app = opts.app;
|
|
1550
|
-
this.controlsDiv = opts.controlsDiv;
|
|
1551
|
-
this.hic = opts.hic;
|
|
1552
|
-
this.colorizeElement = new ColorizeElement();
|
|
1553
|
-
this.parent = opts.parent;
|
|
1554
|
-
this.error = opts.error;
|
|
1555
|
-
}
|
|
1556
|
-
static {
|
|
1557
|
-
this.type = "controlPanel";
|
|
1558
|
-
}
|
|
1559
|
-
getState(appState) {
|
|
1560
|
-
return appState;
|
|
1561
|
-
}
|
|
1562
|
-
addLabel(tr, text) {
|
|
1563
|
-
return tr.append("td").style("color", "#858585").style("font-size", ".8em").style("vertical-align", text.toUpperCase() == "VIEW" ? "top" : "middle").text(text.toUpperCase());
|
|
1564
|
-
}
|
|
1565
|
-
init() {
|
|
1566
|
-
const state = this.app.getState();
|
|
1567
|
-
const menuWrapper = this.controlsDiv.attr("data-testid", "sjpp-hic-control-panel").style("background", "rgb(253, 250, 244)").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc");
|
|
1568
|
-
let menuVisible = true;
|
|
1569
|
-
this.controlsDiv.append("button").attr("data-testid", "sjpp-hic-burger-btn").style("display", "block").style("border", "none").style("font-size", "1.5em").style("background", "none").html("≡").on("click", () => {
|
|
1570
|
-
menuVisible = !menuVisible;
|
|
1571
|
-
menu.style("display", menuVisible ? "block" : "none");
|
|
1572
|
-
});
|
|
1573
|
-
const menu = menuWrapper.append("div").attr("class", "sjpp-hic-menu").attr("data-testid", "sjpp-hic-menu").style("display", menuVisible ? "block" : "none");
|
|
1574
|
-
const menuTable = menu.append("table").style("border-spacing", "3px");
|
|
1575
|
-
this.controls.normalizationRow = menuTable.append("tr");
|
|
1576
|
-
this.addLabel(this.controls.normalizationRow, "NORMALIZATION");
|
|
1577
|
-
this.controls.nmeth = new NormalizationMethodControl(
|
|
1578
|
-
this.controls.normalizationRow.append("td").attr("class", "sjpp-nmeth-select"),
|
|
1579
|
-
this.hic.normalization,
|
|
1580
|
-
state.defaultNmeth,
|
|
1581
|
-
this.dropdownCallback
|
|
1582
|
-
);
|
|
1583
|
-
this.controls.nmeth.render();
|
|
1584
|
-
this.controls.minCutoffRow = menuTable.append("tr");
|
|
1585
|
-
this.controls.minCutoffLabel = this.addLabel(this.controls.minCutoffRow, "");
|
|
1586
|
-
this.controls.inputBpMinV = new CutoffControl(
|
|
1587
|
-
this.controls.minCutoffRow.append("td"),
|
|
1588
|
-
this.parent("min"),
|
|
1589
|
-
this.minCallback
|
|
1590
|
-
).render({ width: "120px" });
|
|
1591
|
-
this.controls.maxCutoffRow = menuTable.append("tr");
|
|
1592
|
-
this.controls.maxCutoffLabel = this.addLabel(this.controls.maxCutoffRow, "");
|
|
1593
|
-
this.controls.inputBpMaxV = new CutoffControl(
|
|
1594
|
-
this.controls.maxCutoffRow.append("td"),
|
|
1595
|
-
this.parent("max"),
|
|
1596
|
-
this.maxCallback
|
|
1597
|
-
).render({ width: "120px" });
|
|
1598
|
-
this.controls.matrixTypeRow = menuTable.append("tr");
|
|
1599
|
-
this.addLabel(this.controls.matrixTypeRow, "matrix type");
|
|
1600
|
-
this.controls.matrixType = new MatrixTypeControl(this.controls.matrixTypeRow.append("td"), this.dropdownCallback);
|
|
1601
|
-
this.controls.matrixType.render();
|
|
1602
|
-
this.controls.widthRow = menuTable.append("tr");
|
|
1603
|
-
this.addLabel(this.controls.widthRow, "WIDTH / height");
|
|
1604
|
-
this.controls.width = this.controls.widthRow.append("td");
|
|
1605
|
-
this.controls.width.attr("data-testid", "sjpp-hic-block-size-input").style("margin-right", "10px").append("input").attr("type", "number").style("width", "80px").style("margin-left", "0px").attr("type", "number").property("value", state.width).on("keyup", async (event) => {
|
|
1606
|
-
if (event.code != "Enter") return;
|
|
1607
|
-
const v = event.target.value;
|
|
1608
|
-
this.app.dispatch({
|
|
1609
|
-
type: "view_update",
|
|
1610
|
-
config: {
|
|
1611
|
-
settings: { widthHeightPx: Number.parseInt(v) }
|
|
1612
|
-
}
|
|
1613
|
-
});
|
|
1614
|
-
});
|
|
1615
|
-
const viewRow = menuTable.append("tr");
|
|
1616
|
-
this.addLabel(viewRow, "VIEW");
|
|
1617
|
-
const viewBtnDiv = viewRow.append("td");
|
|
1618
|
-
this.controls.view = viewBtnDiv.append("span").attr("data-testid", "sjpp-hic-view-span").style("padding-right", "5px").style("display", "block");
|
|
1619
|
-
this.controls.genomeViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-genome-view-btn").style("display", "none").style("padding", "2px").style("margin-top", "4px").html("≪ Genome").on("click", async () => {
|
|
1620
|
-
await this.app.dispatch({
|
|
1621
|
-
type: "view_create",
|
|
1622
|
-
view: "genome",
|
|
1623
|
-
config: {
|
|
1624
|
-
x: {},
|
|
1625
|
-
y: {}
|
|
1626
|
-
}
|
|
1627
|
-
});
|
|
1628
|
-
});
|
|
1629
|
-
this.controls.chrpairViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-chrpair-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").on("click", async () => {
|
|
1630
|
-
const currState = this.app.getState();
|
|
1631
|
-
await this.app.dispatch({
|
|
1632
|
-
type: "view_create",
|
|
1633
|
-
view: "chrpair",
|
|
1634
|
-
config: {
|
|
1635
|
-
x: {
|
|
1636
|
-
chr: currState.x.chr
|
|
1637
|
-
},
|
|
1638
|
-
y: {
|
|
1639
|
-
chr: currState.y.chr
|
|
1640
|
-
}
|
|
1641
|
-
}
|
|
1642
|
-
});
|
|
1643
|
-
});
|
|
1644
|
-
this.controls.horizontalViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-horizontal-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("Horizontal View ≫").on("click", async () => {
|
|
1645
|
-
await this.app.dispatch({
|
|
1646
|
-
type: "view_create",
|
|
1647
|
-
view: "horizontal"
|
|
1648
|
-
});
|
|
1649
|
-
});
|
|
1650
|
-
this.controls.detailViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-detail-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("≪ Detailed View").on("click", async () => {
|
|
1651
|
-
await this.app.dispatch({
|
|
1652
|
-
type: "view_create",
|
|
1653
|
-
view: "detail"
|
|
1654
|
-
});
|
|
1655
|
-
});
|
|
1656
|
-
this.controls.zoomDiv = menuTable.append("tr").attr("data-testid", "sjpp-hic-zoom-div").style("display", state.currView == "detail" ? "contents" : "none");
|
|
1657
|
-
this.addLabel(this.controls.zoomDiv, "ZOOM");
|
|
1658
|
-
const zoomDiv = this.controls.zoomDiv.append("td");
|
|
1659
|
-
this.controls.zoomIn = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-in-btn").style("margin-right", "10px").text("In").on("click", () => {
|
|
1660
|
-
this.zoomBlockCallback(false);
|
|
1661
|
-
});
|
|
1662
|
-
this.controls.zoomOut = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-out-btn").style("margin-right", "10px").text("Out").on("click", () => {
|
|
1663
|
-
this.zoomBlockCallback(true);
|
|
1664
|
-
});
|
|
1665
|
-
}
|
|
1666
|
-
showBtns() {
|
|
1667
|
-
const state = this.app.getState();
|
|
1668
|
-
this.controls.genomeViewBtn.style("display", state.currView === "genome" ? "none" : "inline-block");
|
|
1669
|
-
if (state.currView === "detail") {
|
|
1670
|
-
this.controls.chrpairViewBtn.html(`≪ Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
|
|
1671
|
-
this.controls.horizontalViewBtn.style("display", "block");
|
|
1672
|
-
this.controls.zoomDiv.style("display", "contents");
|
|
1673
|
-
this.controls.detailViewBtn.style("display", "none");
|
|
1674
|
-
} else if (state.currView === "horizontal") {
|
|
1675
|
-
this.controls.chrpairViewBtn.html(`≪ Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
|
|
1676
|
-
this.controls.detailViewBtn.style("display", "block");
|
|
1677
|
-
this.controls.horizontalViewBtn.style("display", "none");
|
|
1678
|
-
this.controls.zoomDiv.style("display", "none");
|
|
1679
|
-
} else {
|
|
1680
|
-
this.controls.chrpairViewBtn.style("display", "none");
|
|
1681
|
-
this.controls.horizontalViewBtn.style("display", "none");
|
|
1682
|
-
this.controls.detailViewBtn.style("display", "none");
|
|
1683
|
-
this.controls.zoomDiv.style("display", "none");
|
|
1684
|
-
this.controls.widthRow.style("display", "none");
|
|
1685
|
-
}
|
|
1686
|
-
}
|
|
1687
|
-
showHideControls() {
|
|
1688
|
-
const state = this.app.getState();
|
|
1689
|
-
this.controls.normalizationRow.style("display", state.currView == "horizontal" ? "none" : "");
|
|
1690
|
-
this.controls.minCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
|
|
1691
|
-
this.controls.maxCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
|
|
1692
|
-
this.controls.matrixTypeRow.style("display", state.currView == "horizontal" ? "none" : "");
|
|
1693
|
-
this.controls.widthRow.style("display", state.currView == "detail" ? "contents" : "none");
|
|
1694
|
-
}
|
|
1695
|
-
main(appState) {
|
|
1696
|
-
const state = this.app.getState(appState);
|
|
1697
|
-
this.controls.nmeth.update(state[state.currView].nmeth);
|
|
1698
|
-
this.controls.matrixType.update(state[state.currView].matrixType);
|
|
1699
|
-
this.controls.zoomDiv.style("display", state.currView == "detail" ? "contents" : "none");
|
|
1700
|
-
if (state.currView == "chrpair") {
|
|
1701
|
-
this.controls.view.text(`${state.x.chr}-${state.y.chr} Pair`);
|
|
1702
|
-
} else {
|
|
1703
|
-
this.controls.view.text(state.currView.charAt(0).toUpperCase() + state.currView.slice(1));
|
|
1704
|
-
}
|
|
1705
|
-
const formatAbsMin = this.parent("absMin") < 1e-5 ? Number(this.parent("absMin")).toExponential(1) : Number(this.parent("absMin").toFixed(6));
|
|
1706
|
-
const formatAbsMax = this.parent("absMax") < 1e-5 ? Number(this.parent("absMax")).toExponential(1) : Number(this.parent("absMax").toFixed(6));
|
|
1707
|
-
this.controls.width.select("input").property("value", state.settings.widthHeightPx);
|
|
1708
|
-
this.controls.inputBpMinV.property("value", this.parent("min"));
|
|
1709
|
-
this.controls.inputBpMaxV.property("value", this.parent("max"));
|
|
1710
|
-
this.controls.minCutoffLabel.html(`MIN CUTOFF <br>(>= ${formatAbsMin})`);
|
|
1711
|
-
this.controls.maxCutoffLabel.html(`MAX CUTOFF <br>(<= ${formatAbsMax})`);
|
|
1712
|
-
this.showBtns();
|
|
1713
|
-
this.showHideControls();
|
|
1714
|
-
}
|
|
1715
|
-
};
|
|
1716
|
-
var controlPanelInit = getCompInit(ControlPanel);
|
|
1717
|
-
|
|
1718
|
-
// tracks/hic/dom/InfoBar.ts
|
|
1719
|
-
var InfoBar = class {
|
|
1720
|
-
constructor(opts) {
|
|
1721
|
-
/** Defaults **/
|
|
1722
|
-
//Color shown on the left of the color scale
|
|
1723
|
-
this.startColor = "white";
|
|
1724
|
-
//Color shown on the right of the color scale
|
|
1725
|
-
this.endColor = "red";
|
|
1726
|
-
this.addLabel = (text) => {
|
|
1727
|
-
return this.labelRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toLowerCase().replace(/\s/g, "-")}-label`).style("color", "#858585").style("font-size", ".8em").style("text-align", "center").style("vertical-align", "middle").text(text.toUpperCase());
|
|
1728
|
-
};
|
|
1729
|
-
this.addValue = (text) => {
|
|
1730
|
-
return this.valueRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toString().toLowerCase().replace(/\s/g, "-")}-value`).style("font-size", "1em").style("text-align", "center").style("vertical-align", "middle").text(text);
|
|
1731
|
-
};
|
|
1732
|
-
this.type = "infoBar";
|
|
1733
|
-
this.app = opts.app;
|
|
1734
|
-
this.hic = opts.hic;
|
|
1735
|
-
const table = opts.infoBarDiv;
|
|
1736
|
-
this.labelRow = table.append("tr");
|
|
1737
|
-
this.valueRow = table.append("tr");
|
|
1738
|
-
this.parent = opts.parent;
|
|
1739
|
-
}
|
|
1740
|
-
async render() {
|
|
1741
|
-
this.addLabel("Version");
|
|
1742
|
-
this.addValue(this.hic.version);
|
|
1743
|
-
this.addLabel("Enzyme");
|
|
1744
|
-
this.addValue(this.hic.enzyme || "N/A");
|
|
1745
|
-
this.addLabel("Resolution");
|
|
1746
|
-
this.resolutionDiv = this.addValue("");
|
|
1747
|
-
this.colorScaleLabel = this.addLabel("Scale");
|
|
1748
|
-
this.colorScaleDiv = this.valueRow.append("td").attr("data-testid", "sjpp-hic-color-scale");
|
|
1749
|
-
const min = this.parent("min");
|
|
1750
|
-
let max = this.parent("max");
|
|
1751
|
-
if (min == max) max = max + 0.01;
|
|
1752
|
-
this.colorScale = new ColorScale({
|
|
1753
|
-
barheight: 20,
|
|
1754
|
-
barwidth: 100,
|
|
1755
|
-
domain: [min, max],
|
|
1756
|
-
fontSize: 12,
|
|
1757
|
-
height: 40,
|
|
1758
|
-
width: 150,
|
|
1759
|
-
holder: this.colorScaleDiv,
|
|
1760
|
-
colors: [this.startColor, this.endColor],
|
|
1761
|
-
position: "20,0",
|
|
1762
|
-
ticks: 3,
|
|
1763
|
-
tickSize: 5,
|
|
1764
|
-
//Do not use min value here on initialization. It's 0 and will not update later.
|
|
1765
|
-
markedValue: 1
|
|
1766
|
-
});
|
|
1767
|
-
}
|
|
1768
|
-
update() {
|
|
1769
|
-
const res = this.parent("calcResolution");
|
|
1770
|
-
let resolutionText;
|
|
1771
|
-
if (res < this.hic.bpresolution[this.hic.bpresolution.length - 1]) {
|
|
1772
|
-
resolutionText = `${res} fragment${res > 1 ? "s" : ""}`;
|
|
1773
|
-
} else {
|
|
1774
|
-
resolutionText = bplen(res);
|
|
1775
|
-
}
|
|
1776
|
-
this.resolutionDiv.text(resolutionText);
|
|
1777
|
-
if (this.parent("state").currView == "horizontal") {
|
|
1778
|
-
this.colorScaleLabel.style("display", "none");
|
|
1779
|
-
this.colorScaleDiv.style("display", "none");
|
|
1780
|
-
} else {
|
|
1781
|
-
this.colorScaleLabel.style("display", "");
|
|
1782
|
-
this.colorScaleDiv.style("display", "");
|
|
1783
|
-
const min = this.parent("min");
|
|
1784
|
-
const max = this.parent("max");
|
|
1785
|
-
if (min < 0) {
|
|
1786
|
-
this.colorScale.colors = ["blue", "white", "red"];
|
|
1787
|
-
this.colorScale.domain = [min, 0, max];
|
|
1788
|
-
} else {
|
|
1789
|
-
this.colorScale.colors = ["white", "red"];
|
|
1790
|
-
this.colorScale.domain = [0, max];
|
|
1791
|
-
}
|
|
1792
|
-
this.colorScale.markedValue = min;
|
|
1793
|
-
this.colorScale.updateScale();
|
|
1794
|
-
}
|
|
1795
|
-
}
|
|
1796
|
-
};
|
|
1797
|
-
|
|
1798
|
-
// tracks/hic/data/DataMapper.ts
|
|
1799
|
-
var DataMapper = class {
|
|
1800
|
-
constructor(hic, percentile) {
|
|
1801
|
-
this.hic = hic;
|
|
1802
|
-
this.percentile = percentile ? percentile / 100 : 0.99;
|
|
1803
|
-
}
|
|
1804
|
-
sortData(data) {
|
|
1805
|
-
const vlst = [];
|
|
1806
|
-
if (data?.items && data?.items.length) {
|
|
1807
|
-
for (const i of data.items) {
|
|
1808
|
-
vlst.push(i[2]);
|
|
1809
|
-
}
|
|
1810
|
-
} else {
|
|
1811
|
-
const blankChrs = /* @__PURE__ */ new Set();
|
|
1812
|
-
for (const d of data) {
|
|
1813
|
-
if (d.lead == "chrM" && !d.items.length || d.lead == "chrY" && !d.items.length) {
|
|
1814
|
-
blankChrs.add(d.lead);
|
|
1815
|
-
continue;
|
|
1816
|
-
}
|
|
1817
|
-
for (const i of d.items) {
|
|
1818
|
-
vlst.push(i[2]);
|
|
1819
|
-
}
|
|
1820
|
-
}
|
|
1821
|
-
if (blankChrs.size) {
|
|
1822
|
-
for (const c of blankChrs) {
|
|
1823
|
-
const idx = this.hic.chrlst.indexOf(c);
|
|
1824
|
-
this.hic.chrlst.splice(idx, 1);
|
|
1825
|
-
}
|
|
1826
|
-
}
|
|
1827
|
-
}
|
|
1828
|
-
const sortedVlst = vlst.sort((a, b) => a - b);
|
|
1829
|
-
const max = sortedVlst[Math.floor(sortedVlst.length * this.percentile)];
|
|
1830
|
-
const min = sortedVlst[0];
|
|
1831
|
-
return [min, max, sortedVlst[sortedVlst.length - 1]];
|
|
1832
|
-
}
|
|
1833
|
-
};
|
|
1834
|
-
|
|
1835
|
-
// tracks/hic/data/GenomeDataFetcher.ts
|
|
1836
|
-
var GenomeDataFetcher = class {
|
|
1837
|
-
constructor(hic, debugmode, errList = []) {
|
|
1838
|
-
this.data = [];
|
|
1839
|
-
this.hic = hic;
|
|
1840
|
-
this.debugmode = debugmode;
|
|
1841
|
-
this.errList = errList || [];
|
|
1842
|
-
}
|
|
1843
|
-
async getData(obj) {
|
|
1844
|
-
if (this.data.length) this.data = [];
|
|
1845
|
-
if (!obj?.matrixType) obj.matrixType = "observed";
|
|
1846
|
-
try {
|
|
1847
|
-
const res = await dofetch3("hicgenome?", {
|
|
1848
|
-
method: "POST",
|
|
1849
|
-
body: JSON.stringify({
|
|
1850
|
-
chrlst: this.hic.chrlst,
|
|
1851
|
-
nmeth: obj.nmeth,
|
|
1852
|
-
resolution: obj.resolution,
|
|
1853
|
-
matrixType: obj.matrixType,
|
|
1854
|
-
file: this.hic.file,
|
|
1855
|
-
url: this.hic.url,
|
|
1856
|
-
nochr: this.hic.nochr
|
|
1857
|
-
})
|
|
1858
|
-
});
|
|
1859
|
-
if (res.error) {
|
|
1860
|
-
const errs = res.error.split("\n");
|
|
1861
|
-
for (const e of errs) {
|
|
1862
|
-
this.errList.push(e);
|
|
1863
|
-
}
|
|
1864
|
-
}
|
|
1865
|
-
return res.data;
|
|
1866
|
-
} catch (e) {
|
|
1867
|
-
this.errList.push(e.message || e);
|
|
1868
|
-
if (e.stack) console.error(e.stack);
|
|
1869
|
-
}
|
|
1870
|
-
}
|
|
1871
|
-
};
|
|
1872
|
-
|
|
1873
|
-
// tracks/hic/data/DataFetcher.ts
|
|
1874
|
-
var DataFetcher = class {
|
|
1875
|
-
constructor(hic, debugmode, errList = []) {
|
|
1876
|
-
this.hic = hic;
|
|
1877
|
-
this.debugmode = debugmode;
|
|
1878
|
-
this.errList = errList || [];
|
|
1879
|
-
}
|
|
1880
|
-
async getData(obj) {
|
|
1881
|
-
if (!obj?.matrixType) obj.matrixType = "observed";
|
|
1882
|
-
const arg = {
|
|
1883
|
-
matrixType: obj.matrixType,
|
|
1884
|
-
file: this.hic.file,
|
|
1885
|
-
url: this.hic.url,
|
|
1886
|
-
pos1: this.hic.nochr ? obj.lead.replace("chr", "") : obj.lead,
|
|
1887
|
-
pos2: this.hic.nochr ? obj.follow.replace("chr", "") : obj.follow,
|
|
1888
|
-
nmeth: obj.nmeth,
|
|
1889
|
-
resolution: obj.resolution
|
|
1890
|
-
};
|
|
1891
|
-
try {
|
|
1892
|
-
const data = await dofetch3("hicdata?", {
|
|
1893
|
-
method: "POST",
|
|
1894
|
-
body: JSON.stringify(arg)
|
|
1895
|
-
});
|
|
1896
|
-
if (data.error) {
|
|
1897
|
-
throw Error(`${obj.lead} - ${obj.follow}: ${data.error.error}`);
|
|
1898
|
-
}
|
|
1899
|
-
if (!data.items || data.items.length == 0) return;
|
|
1900
|
-
return data;
|
|
1901
|
-
} catch (e) {
|
|
1902
|
-
this.errList.push(e.message || e);
|
|
1903
|
-
if (e.stack) console.error(e.stack);
|
|
1904
|
-
}
|
|
1905
|
-
}
|
|
1906
|
-
};
|
|
1907
|
-
|
|
1908
|
-
// tracks/hic/HicComponent.ts
|
|
1909
|
-
var HicComponent = class _HicComponent {
|
|
1910
|
-
constructor(opts) {
|
|
1911
|
-
this.genomeData = [];
|
|
1912
|
-
this.calcResolution = null;
|
|
1913
|
-
this.firstRender = true;
|
|
1914
|
-
this.min = 0;
|
|
1915
|
-
this.absMin = 0;
|
|
1916
|
-
this.max = 0;
|
|
1917
|
-
this.absMax = 0;
|
|
1918
|
-
this.hasStatePreMain = true;
|
|
1919
|
-
this.type = _HicComponent.type;
|
|
1920
|
-
this.hic = opts.hic;
|
|
1921
|
-
this.state = opts.state;
|
|
1922
|
-
this.dom = opts.dom;
|
|
1923
|
-
this.errList = opts.errList;
|
|
1924
|
-
this.plotDiv = this.dom.plotDiv.append("table").classed("sjpp-hic-plot-main", true);
|
|
1925
|
-
const tr1 = this.plotDiv.append("tr");
|
|
1926
|
-
const tr2 = this.plotDiv.append("tr");
|
|
1927
|
-
this.plotDiv = {
|
|
1928
|
-
plot: tr1.append("td").classed("sjpp-hic-plot", true).attr("data-testid", "sjpp-hic-plot"),
|
|
1929
|
-
yAxis: tr1.append("td").classed("sjpp-hic-plot-yaxis", true).attr("data-testid", "sjpp-hic-yaxis"),
|
|
1930
|
-
xAxis: tr2.append("td").classed("sjpp-hic-plot-xaxis", true).attr("data-testid", "sjpp-hic-xaxis"),
|
|
1931
|
-
blank: tr2.append("td")
|
|
1932
|
-
};
|
|
1933
|
-
this.app = opts.app;
|
|
1934
|
-
this.dataMapper = new DataMapper(this.hic, opts.state.maxCutoffPercentile);
|
|
1935
|
-
this.activeView = this.state.currView;
|
|
1936
|
-
this.error = opts.error;
|
|
1937
|
-
this.resolution = new Resolution(this.error);
|
|
1938
|
-
this.parent = (prop) => {
|
|
1939
|
-
return this[prop];
|
|
1940
|
-
};
|
|
1941
|
-
this.detailDataMapper = new DetailDataMapper(this.hic, this.errList, this.parent);
|
|
1942
|
-
}
|
|
1943
|
-
static {
|
|
1944
|
-
this.type = "view";
|
|
1945
|
-
}
|
|
1946
|
-
getState(appState) {
|
|
1947
|
-
return appState;
|
|
1948
|
-
}
|
|
1949
|
-
reactsTo(action) {
|
|
1950
|
-
if (action.type.startsWith("view")) return true;
|
|
1951
|
-
else return false;
|
|
1952
|
-
}
|
|
1953
|
-
initView() {
|
|
1954
|
-
const opts = {
|
|
1955
|
-
plotDiv: this.plotDiv,
|
|
1956
|
-
hic: this.hic,
|
|
1957
|
-
app: this.app,
|
|
1958
|
-
parent: (prop) => {
|
|
1959
|
-
return this[prop];
|
|
1960
|
-
}
|
|
1961
|
-
};
|
|
1962
|
-
if (this.state.currView == "genome") {
|
|
1963
|
-
opts["data"] = this.data;
|
|
1964
|
-
this.genome = new GenomeView(opts);
|
|
1965
|
-
this.genome.render();
|
|
1966
|
-
} else if (this.state.currView === "chrpair") {
|
|
1967
|
-
opts["items"] = this.data;
|
|
1968
|
-
this.chrpair = new ChrPairView(opts);
|
|
1969
|
-
this.chrpair.render();
|
|
1970
|
-
} else if (this.state.currView === "detail") {
|
|
1971
|
-
opts["data"] = this.data;
|
|
1972
|
-
this.detail = new DetailView(opts);
|
|
1973
|
-
this.detail.render();
|
|
1974
|
-
} else if (this.state.currView === "horizontal") {
|
|
1975
|
-
this.horizontal = new HorizontalView(opts);
|
|
1976
|
-
this.horizontal.render();
|
|
1977
|
-
} else {
|
|
1978
|
-
throw Error(`Unknown view: ${this.state.currView}`);
|
|
1979
|
-
}
|
|
1980
|
-
}
|
|
1981
|
-
async fetchData(obj) {
|
|
1982
|
-
if (this.data?.length) this.data = [];
|
|
1983
|
-
if (this.state.currView == "genome") {
|
|
1984
|
-
if (this.activeView != "genome" && this.genomeData?.length) this.data = this.genomeData;
|
|
1985
|
-
else {
|
|
1986
|
-
const genomeFetcher = new GenomeDataFetcher(this.hic, true, this.errList);
|
|
1987
|
-
this.genomeData = await genomeFetcher.getData(obj);
|
|
1988
|
-
this.data = this.genomeData;
|
|
1989
|
-
}
|
|
1990
|
-
} else if (this.state.currView == "detail") {
|
|
1991
|
-
this.data = await this.detailDataMapper.getData(this.state.x, this.state.y, this.fragData);
|
|
1992
|
-
} else {
|
|
1993
|
-
if (!this.state?.x?.chr || !this.state?.y?.chr) {
|
|
1994
|
-
this.errList.push(`No positions provided for ${this.activeView} view.`);
|
|
1995
|
-
return;
|
|
1996
|
-
} else {
|
|
1997
|
-
const chrx = this.state.x;
|
|
1998
|
-
const chry = this.state.y;
|
|
1999
|
-
obj["lead"] = `${chrx.start && chrx.stop ? `${chrx.chr}:${chrx.start}-${chrx.stop}` : chrx.chr}`;
|
|
2000
|
-
obj["follow"] = `${chry.start && chry.stop ? `${chry.chr}:${chry.start}-${chry.stop}` : chry.chr}`;
|
|
2001
|
-
}
|
|
2002
|
-
const dataFetcher = new DataFetcher(this.hic, true, this.errList);
|
|
2003
|
-
this.data = await dataFetcher.getData(obj);
|
|
2004
|
-
}
|
|
2005
|
-
}
|
|
2006
|
-
async setResolution(appState) {
|
|
2007
|
-
const state = this.app.getState(appState);
|
|
2008
|
-
this.calcResolution = this.resolution.getResolution(state, this.hic);
|
|
2009
|
-
if (state.currView == "detail" && this.calcResolution == null) {
|
|
2010
|
-
await this.detailDataMapper.getFragData(state.x, state.y);
|
|
2011
|
-
this.fragData = this.detailDataMapper.frag;
|
|
2012
|
-
const maxFragSpan = Math.min(
|
|
2013
|
-
this.fragData.x.stop - this.fragData.x.start,
|
|
2014
|
-
this.fragData.y.stop - this.fragData.y.start
|
|
2015
|
-
);
|
|
2016
|
-
this.calcResolution = this.resolution.findResFromArray(
|
|
2017
|
-
maxFragSpan,
|
|
2018
|
-
state.minFragSpan,
|
|
2019
|
-
this.hic.fragresolution,
|
|
2020
|
-
true
|
|
2021
|
-
);
|
|
2022
|
-
} else {
|
|
2023
|
-
this.fragData = null;
|
|
2024
|
-
}
|
|
2025
|
-
return this.calcResolution;
|
|
2026
|
-
}
|
|
2027
|
-
async setDataArgs(appState) {
|
|
2028
|
-
const state = this.app.getState(appState);
|
|
2029
|
-
const currView = state[state.currView];
|
|
2030
|
-
const args = {
|
|
2031
|
-
nmeth: currView.nmeth,
|
|
2032
|
-
resolution: await this.setResolution(appState),
|
|
2033
|
-
matrixType: currView.matrixType
|
|
2034
|
-
};
|
|
2035
|
-
if (state.currView == "chrpair") {
|
|
2036
|
-
args["lead"] = state.x.chr;
|
|
2037
|
-
args["follow"] = state.y.chr;
|
|
2038
|
-
}
|
|
2039
|
-
return args;
|
|
2040
|
-
}
|
|
2041
|
-
async getViewData(appState) {
|
|
2042
|
-
const args = await this.setDataArgs(appState);
|
|
2043
|
-
await this.fetchData(args);
|
|
2044
|
-
if (this.data?.length > 0 || this.data?.items?.length > 0) {
|
|
2045
|
-
const [min, max, absMax] = this.dataMapper.sortData(this.data);
|
|
2046
|
-
this.min = this.absMin = min;
|
|
2047
|
-
this.max = max;
|
|
2048
|
-
this.absMax = absMax;
|
|
2049
|
-
} else {
|
|
2050
|
-
if (this.state.currView != "genome") {
|
|
2051
|
-
const state = this.app.getState(appState);
|
|
2052
|
-
const xPosMessage = state.x?.start ? `${state.x.chr}:${state.x.start}-${state.x.stop}` : state.x.chr;
|
|
2053
|
-
const yPosMessage = state.y?.start ? `${state.y.chr}:${state.y.start}-${state.y.stop}` : state.y.chr;
|
|
2054
|
-
this.errList.push(`No data returned for ${xPosMessage} and ${yPosMessage}`);
|
|
2055
|
-
}
|
|
2056
|
-
}
|
|
2057
|
-
}
|
|
2058
|
-
async init() {
|
|
2059
|
-
this.components = {
|
|
2060
|
-
controls: await controlPanelInit({
|
|
2061
|
-
app: this.app,
|
|
2062
|
-
controlsDiv: this.dom.controlsDiv,
|
|
2063
|
-
hic: this.hic,
|
|
2064
|
-
parent: (prop, value) => {
|
|
2065
|
-
if (value) this[prop] = value;
|
|
2066
|
-
return this[prop];
|
|
2067
|
-
},
|
|
2068
|
-
error: this.error.bind(this)
|
|
2069
|
-
})
|
|
2070
|
-
};
|
|
2071
|
-
this.infoBar = new InfoBar({
|
|
2072
|
-
app: this.app,
|
|
2073
|
-
infoBarDiv: this.dom.infoBarDiv.append("table").style("border-spacing", "3px"),
|
|
2074
|
-
hic: this.hic,
|
|
2075
|
-
parent: (prop) => {
|
|
2076
|
-
return this[prop];
|
|
2077
|
-
}
|
|
2078
|
-
});
|
|
2079
|
-
this.infoBar.render();
|
|
2080
|
-
}
|
|
2081
|
-
async main(appState) {
|
|
2082
|
-
if (this.errList.length) {
|
|
2083
|
-
this.app.dispatch({ type: "loading_active", active: false });
|
|
2084
|
-
return;
|
|
2085
|
-
}
|
|
2086
|
-
const state = this.app.getState(appState);
|
|
2087
|
-
if (this.firstRender == true) {
|
|
2088
|
-
this.firstRender = false;
|
|
2089
|
-
await this.getViewData(appState);
|
|
2090
|
-
this.initView();
|
|
2091
|
-
} else {
|
|
2092
|
-
if (state.currView != "horizontal") {
|
|
2093
|
-
this.app.dispatch({ type: "loading_active", active: true });
|
|
2094
|
-
await this.getViewData(appState);
|
|
2095
|
-
}
|
|
2096
|
-
if (this.activeView != state.currView) {
|
|
2097
|
-
if (this.activeView == "genome") {
|
|
2098
|
-
this.genome.svg.remove();
|
|
2099
|
-
} else {
|
|
2100
|
-
this.plotDiv.xAxis.selectAll("*").remove();
|
|
2101
|
-
this.plotDiv.yAxis.selectAll("*").remove();
|
|
2102
|
-
this.plotDiv.plot.selectAll("*").remove();
|
|
2103
|
-
}
|
|
2104
|
-
this.activeView = state.currView;
|
|
2105
|
-
this.initView();
|
|
2106
|
-
} else {
|
|
2107
|
-
this[state.currView].update(this.data);
|
|
2108
|
-
}
|
|
2109
|
-
}
|
|
2110
|
-
this.infoBar.update();
|
|
2111
|
-
if (this.errList.length) {
|
|
2112
|
-
this.error(this.errList);
|
|
2113
|
-
this.app.dispatch({ type: "loading_active", active: false });
|
|
2114
|
-
}
|
|
2115
|
-
}
|
|
2116
|
-
};
|
|
2117
|
-
var viewCompInit = getCompInit(HicComponent);
|
|
2118
|
-
|
|
2119
|
-
// tracks/hic/HicApp.ts
|
|
2120
|
-
var HicApp = class _HicApp extends AppBase {
|
|
2121
|
-
constructor(opts) {
|
|
2122
|
-
super(opts);
|
|
2123
|
-
this.views = ["genome", "chrpair", "detail", "horizontal"];
|
|
2124
|
-
this.errList = [];
|
|
2125
|
-
/** Required for rx but not in use */
|
|
2126
|
-
this.wasDestroyed = false;
|
|
2127
|
-
this.type = _HicApp.type;
|
|
2128
|
-
this.hic = {
|
|
2129
|
-
enzyme: opts.enzyme,
|
|
2130
|
-
file: opts.file,
|
|
2131
|
-
url: opts.url,
|
|
2132
|
-
genome: opts.genome,
|
|
2133
|
-
holder: opts.holder,
|
|
2134
|
-
hostUrl: opts.hostUrl,
|
|
2135
|
-
jwt: opts.jwt,
|
|
2136
|
-
position1: opts.position1,
|
|
2137
|
-
position2: opts.position2,
|
|
2138
|
-
maxCutoffPercentile: opts.maxCutoffPercentile,
|
|
2139
|
-
name: "name" in opts ? opts.name : "Hi-C",
|
|
2140
|
-
tklist: "tklst" in opts ? opts.tklst : [],
|
|
2141
|
-
state: "state" in opts ? opts.state : {}
|
|
2142
|
-
};
|
|
2143
|
-
this.dom = {
|
|
2144
|
-
errorDiv: opts.holder.append("div").classed("sjpp-hic-error", true),
|
|
2145
|
-
controlsDiv: opts.holder.append("div").classed("sjpp-hic-controls", true).style("display", "inline-block"),
|
|
2146
|
-
infoBarDiv: opts.holder.append("div").classed("sjpp-hic-infobar", true).style("display", "inline-block").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc"),
|
|
2147
|
-
loadingDiv: select_default("body").append("div").attr("id", "sjpp-loading-overlay"),
|
|
2148
|
-
plotDiv: opts.holder.append("div").classed("sjpp-hic-main", true).style("display", "inline-block"),
|
|
2149
|
-
tip: new Menu()
|
|
2150
|
-
};
|
|
2151
|
-
}
|
|
2152
|
-
static {
|
|
2153
|
-
this.type = "app";
|
|
2154
|
-
}
|
|
2155
|
-
async error(err) {
|
|
2156
|
-
if (err && typeof err == "string") this.errList.push(err);
|
|
2157
|
-
showErrorsWithCounter(this.errList, this.dom.errorDiv);
|
|
2158
|
-
this.errList = [];
|
|
2159
|
-
}
|
|
2160
|
-
determineView() {
|
|
2161
|
-
if (!this.hic.position1 && !this.hic.position2 && !this.hic.state.currView) this.hic.state.currView = "genome";
|
|
2162
|
-
if (!this.hic.position1 && this.hic.position2) this.errList.push("Missing first position");
|
|
2163
|
-
if (this.hic.position1 && !this.hic.position2) this.errList.push("Missing second position");
|
|
2164
|
-
if (this.hic.position1 && this.hic.position2) {
|
|
2165
|
-
const pos1 = this.hic.position1.split(/[:-]/);
|
|
2166
|
-
const pos2 = this.hic.position2.split(/[:-]/);
|
|
2167
|
-
this.hic.state.x = { chr: pos1[0] };
|
|
2168
|
-
this.hic.state.y = { chr: pos2[0] };
|
|
2169
|
-
if (!Number.isNaN(+pos1[1]) && !Number.isNaN(+pos1[2])) {
|
|
2170
|
-
this.hic.state.x.start = +pos1[1];
|
|
2171
|
-
this.hic.state.x.stop = +pos1[2];
|
|
2172
|
-
this.hic.state.y.start = +pos2[1];
|
|
2173
|
-
this.hic.state.y.stop = +pos2[2];
|
|
2174
|
-
this.hic.state.currView = "detail";
|
|
2175
|
-
} else {
|
|
2176
|
-
this.hic.state.currView = "chrpair";
|
|
2177
|
-
}
|
|
2178
|
-
} else {
|
|
2179
|
-
if (!this.views.some((v) => v === this.hic.state.currView)) this.error(`Unknown view: ${this.hic.state.currView}`);
|
|
2180
|
-
else return this.hic.state.currView;
|
|
2181
|
-
}
|
|
2182
|
-
}
|
|
2183
|
-
getViewsConfig() {
|
|
2184
|
-
if (this.hic.maxCutoffPercentile) this.hic.state.maxCutoffPercentile = this.hic.maxCutoffPercentile;
|
|
2185
|
-
let nmeth;
|
|
2186
|
-
if (this.hic["normalization"]?.length > 0) {
|
|
2187
|
-
if (!this.hic["normalization"].includes("NONE")) this.hic["normalization"].unshift("NONE");
|
|
2188
|
-
nmeth = this.hic["normalization"][0];
|
|
2189
|
-
} else {
|
|
2190
|
-
nmeth = "NONE";
|
|
2191
|
-
}
|
|
2192
|
-
if (this.hic.state.currView) {
|
|
2193
|
-
if (!this.hic.state[this.hic.state.currView]) this.hic.state[this.hic.state.currView] = {};
|
|
2194
|
-
if (!this.hic.state[this.hic.state.currView]?.matrixType) {
|
|
2195
|
-
this.hic.state[this.hic.state.currView].matrixType = "observed";
|
|
2196
|
-
}
|
|
2197
|
-
if (!this.hic.state[this.hic.state.currView]?.nmeth) {
|
|
2198
|
-
this.hic.state[this.hic.state.currView].nmeth = nmeth;
|
|
2199
|
-
}
|
|
2200
|
-
}
|
|
2201
|
-
for (const v of this.views) {
|
|
2202
|
-
if (!this.hic.state[v]) {
|
|
2203
|
-
this.hic.state[v] = {
|
|
2204
|
-
matrixType: "observed",
|
|
2205
|
-
nmeth
|
|
2206
|
-
};
|
|
2207
|
-
}
|
|
2208
|
-
}
|
|
2209
|
-
}
|
|
2210
|
-
async init() {
|
|
2211
|
-
this.determineView();
|
|
2212
|
-
try {
|
|
2213
|
-
await hicParseFile(this.hic, true, this.errList);
|
|
2214
|
-
this.getViewsConfig();
|
|
2215
|
-
this.store = await hicStoreInit({ app: this.api, state: this.hic.state });
|
|
2216
|
-
this.state = await this.store.copyState();
|
|
2217
|
-
this.components = {
|
|
2218
|
-
loadingOverlay: await loadingInit({
|
|
2219
|
-
app: this.api,
|
|
2220
|
-
loadingDiv: this.dom.loadingDiv
|
|
2221
|
-
}),
|
|
2222
|
-
view: await viewCompInit({
|
|
2223
|
-
app: this.api,
|
|
2224
|
-
state: this.state,
|
|
2225
|
-
dom: this.dom,
|
|
2226
|
-
hic: this.hic,
|
|
2227
|
-
errList: this.errList,
|
|
2228
|
-
error: this.error
|
|
2229
|
-
})
|
|
2230
|
-
};
|
|
2231
|
-
await this.api.dispatch();
|
|
2232
|
-
} catch (e) {
|
|
2233
|
-
console.error(e.stack || e);
|
|
2234
|
-
}
|
|
2235
|
-
}
|
|
2236
|
-
main() {
|
|
2237
|
-
if (this.errList.length) {
|
|
2238
|
-
this.error(this.errList);
|
|
2239
|
-
this.dom.loadingDiv.style("display", "none");
|
|
2240
|
-
return;
|
|
2241
|
-
}
|
|
2242
|
-
}
|
|
2243
|
-
};
|
|
2244
|
-
var hicInit = getAppInit(HicApp);
|
|
2245
|
-
export {
|
|
2246
|
-
hicInit
|
|
2247
|
-
};
|
|
2248
|
-
//# sourceMappingURL=HicApp-XPZVZXB7.js.map
|