@sjcrh/proteinpaint-client 2.184.0 → 2.185.0

package/dist/Volcano-WMNFZSX2.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../plots/volcano/viewModel/VolcanoViewModel.ts", "../plots/volcano/interactions/VolcanoInteractions.ts", "../plots/volcano/view/DataPointMouseEvents.ts", "../plots/volcano/view/VolcanoPlotView.ts", "../plots/volcano/VolcanoControlInputs.ts", "../plots/volcano/Volcano.ts"],
+  "sourcesContent": ["import type {\n\tVolcanoPlotDimensions,\n\tVolcanoPlotConfig,\n\tVolcanoPValueTableData,\n\tVolcanoViewData,\n\tDataPointEntry\n} from '../VolcanoTypes'\nimport type { ValidatedVolcanoSettings } from '../settings/Settings'\nimport type { DEFullResponse } from '#types'\nimport { scaleLinear } from 'd3-scale'\nimport { roundValueAuto } from '#shared/roundValue.js'\nimport { getSampleNum } from '../settings/defaults'\nimport { getGroupColors } from '../colors'\nimport { DNA_METHYLATION, GENE_EXPRESSION, SINGLECELL_CELLTYPE } from '#shared/terms.js'\n\nexport class VolcanoViewModel {\n\tconfig: any\n\tdataType: string\n\tresponse: DEFullResponse\n\tpValueTable: VolcanoPValueTableData\n\tsettings: any\n\ttermType: string\n\tviewData: VolcanoViewData\n\tnumSignificant = 0\n\tnumNonSignificant = 0\n\tminLogFoldChange = 0\n\tmaxLogFoldChange = 0\n\t//Used for the y axis domain\n\tminLogPValue = 0\n\tmaxLogPValue = 0\n\t//Used in place of 0 p values that cannot be log transformed\n\tminNonZeroPValue = 10e-10\n\t//The x coord flush with the left side of the plot\n\tplotX: number\n\treadonly offset = 10\n\treadonly bottomPad = 60\n\treadonly horizPad = 70\n\treadonly topPad = 40\n\t/** Interactive rows returned by the server: threshold-passing dots, sorted by\n\t * significance. The full scatter lives in `response.volcanoPng`. */\n\tdataRows: DataPointEntry[]\n\n\tconstructor(config: VolcanoPlotConfig, response: DEFullResponse, settings: ValidatedVolcanoSettings) {\n\t\tthis.config = config\n\t\tthis.response = response\n\t\tthis.plotX = this.horizPad + this.offset * 2\n\n\t\tthis.dataRows = response.data.dots as DataPointEntry[]\n\n\t\t// Shared helper (colors.ts) so the SVG overlay and the server PNG paint\n\t\t// each side in the exact same hex.\n\t\tconst { caseColor, controlColor } = getGroupColors(this.config)\n\t\tconst barplot = { colorNegative: controlColor, colorPositive: caseColor }\n\n\t\tthis.pValueTable = {\n\t\t\tcolumns: [\n\t\t\t\t{ label: 'log\u2082(fold-change)', barplot, sortable: true },\n\t\t\t\t{ label: 'Original p-value', sortable: true },\n\t\t\t\t{ label: 'Adjusted p-value', sortable: true }\n\t\t\t],\n\t\t\t/** Arr set in setPointData() if settings.showPValueTable is true to\n\t\t\t * prevent unnecessary data processing when the table is not shown */\n\t\t\trows: [],\n\t\t\theight: settings.height + this.topPad\n\t\t}\n\t\tthis.settings = settings\n\t\tthis.termType = config.termType\n\t\tthis.dataType = this.setDataType()\n\n\t\tthis.setMinMaxValues()\n\n\t\tconst plotDim = this.setPlotDimensions()\n\t\tthis.setPTableColumns()\n\t\tconst pointData = this.setPointData(plotDim, controlColor, caseColor)\n\n\t\tif (this.settings.showPValueTable) {\n\t\t\t//Get all rows data for the pValueTable in setPointsData, then sort by fold change\n\t\t\tconst foldChangeIdx = this.pValueTable.columns.findIndex(c => c.label.includes('log\u2082(fold-change)'))\n\t\t\tthis.pValueTable.rows.sort((a: any, b: any) => b[foldChangeIdx].value - a[foldChangeIdx].value)\n\t\t}\n\n\t\tthis.viewData = {\n\t\t\timages: response.images || [],\n\t\t\ttermInfo: this.setTermInfo(plotDim),\n\t\t\tplotDim,\n\t\t\tpointData,\n\t\t\tpValueTableData: this.pValueTable,\n\t\t\tstatsData: this.setStatsData(),\n\t\t\tuserActions: this.setUserActions(),\n\t\t\tvolcanoPng: response.data.volcanoPng,\n\t\t\tplotExtent: response.data.plotExtent\n\t\t}\n\t}\n\n\tsetDataType() {\n\t\tif (this.termType == GENE_EXPRESSION) return 'genes'\n\t\telse if (this.termType == DNA_METHYLATION) return 'promoters'\n\t\telse if (this.termType == SINGLECELL_CELLTYPE) return 'genes' //'cells'??\n\t\telse throw new Error(`Unknown termType: ${this.termType}`)\n\t}\n\n\tsetMinMaxValues() {\n\t\t// The server-drawn PNG owns the axes; we adopt its extents verbatim so\n\t\t// overlay circles land on their counterparts in the PNG. Also adopt the\n\t\t// server's minNonZeroPValue so p=0 rows are capped at the same y position\n\t\t// the PNG used.\n\t\tconst ext = this.response.data.plotExtent\n\t\tthis.minLogFoldChange = ext.xMin\n\t\tthis.maxLogFoldChange = ext.xMax\n\t\tthis.minLogPValue = ext.yMin\n\t\tthis.maxLogPValue = ext.yMax\n\t\tif (ext.minNonZeroPValue > 0) this.minNonZeroPValue = ext.minNonZeroPValue\n\t}\n\n\tsetPlotDimensions() {\n\t\tconst xScale = scaleLinear().domain([this.minLogFoldChange, this.maxLogFoldChange]).range([0, this.settings.width])\n\t\tconst yScale = scaleLinear().domain([this.minLogPValue, this.maxLogPValue]).range([this.settings.height, 0])\n\n\t\treturn {\n\t\t\tsvg: {\n\t\t\t\t//20 is for the term info above the plot\n\t\t\t\theight: this.settings.height + this.topPad + this.bottomPad * 2 + this.offset * 3,\n\t\t\t\twidth: this.settings.width + this.horizPad * 2\n\t\t\t},\n\t\t\ttop: {\n\t\t\t\tx: this.plotX,\n\t\t\t\ty: 5\n\t\t\t},\n\t\t\txAxisLabel: {\n\t\t\t\tx: this.horizPad + this.settings.width / 2 + this.offset,\n\t\t\t\ty: this.topPad + this.settings.height + this.bottomPad + this.offset\n\t\t\t},\n\t\t\txScale: {\n\t\t\t\tscale: xScale,\n\t\t\t\tx: this.plotX,\n\t\t\t\ty: this.settings.height + this.topPad + this.offset * 2\n\t\t\t},\n\t\t\tyAxisLabel: {\n\t\t\t\ttext: `-log10(${this.settings.pValueType} P value)`,\n\t\t\t\tx: this.horizPad / 3,\n\t\t\t\ty: this.topPad + this.settings.height / 2\n\t\t\t},\n\t\t\tyScale: {\n\t\t\t\tscale: yScale,\n\t\t\t\tx: this.horizPad,\n\t\t\t\ty: this.topPad\n\t\t\t},\n\t\t\tplot: {\n\t\t\t\theight: this.settings.height,\n\t\t\t\twidth: this.settings.width,\n\t\t\t\tx: this.plotX,\n\t\t\t\ty: this.topPad\n\t\t\t},\n\t\t\tlogFoldChangeLine: {\n\t\t\t\tx: xScale(0) + this.plotX,\n\t\t\t\ty1: this.topPad,\n\t\t\t\ty2: this.settings.height + this.offset * 4\n\t\t\t}\n\t\t}\n\t}\n\n\tsetTermInfo(\n\t\tplotDim: VolcanoPlotDimensions\n\t\t// caseColor: string,\n\t\t// controlColor: string\n\t) {\n\t\tif (this.termType != GENE_EXPRESSION && this.termType != DNA_METHYLATION) return\n\t\tconst getLabel = (name: string) => {\n\t\t\tif (name.length >= 25) return name.substring(0, 20) + '...'\n\t\t\treturn name\n\t\t}\n\n\t\treturn {\n\t\t\t//Set slightly above the plot\n\t\t\ty: plotDim.top.y + 10,\n\t\t\tfirst: {\n\t\t\t\t// color: controlColor || this.settings.defaultSignColor,\n\t\t\t\tlabel: getLabel(`${this.config.samplelst.groups[0].name} (${this.response.sample_size1})`),\n\t\t\t\tx: 0\n\t\t\t\t// rectX: this.settings.width/2 - 10,\n\t\t\t},\n\t\t\tsecond: {\n\t\t\t\t// color: caseColor || this.settings.defaultSignColor,\n\t\t\t\tlabel: getLabel(`${this.config.samplelst.groups[1].name} (${this.response.sample_size2})`),\n\t\t\t\tx: this.settings.width\n\t\t\t\t// rectX: this.settings.width/2 + 10,\n\t\t\t}\n\t\t}\n\t}\n\n\tsetPointData(plotDim: VolcanoPlotDimensions, controlColor: string, caseColor: string) {\n\t\tconst radius = Math.max(this.settings.width, this.settings.height) / 80\n\t\tconst dataCopy: any = structuredClone(this.dataRows)\n\t\tfor (const d of dataCopy) {\n\t\t\tconst highlightKey = this.termType === DNA_METHYLATION ? d.promoter_id : d.gene_name\n\t\t\td.highlighted = this.config?.highlightedData?.includes(highlightKey)\n\t\t\t// Every row in response.data passed the server's thresholds by definition.\n\t\t\td.significant = true\n\t\t\tthis.getGenesColor(d, d.significant, controlColor, caseColor)\n\t\t\tif (d.significant) {\n\t\t\t\tthis.numSignificant++\n\t\t\t\tconst row = [\n\t\t\t\t\t{ value: roundValueAuto(d.fold_change) },\n\t\t\t\t\t{ value: roundValueAuto(d.original_p_value) },\n\t\t\t\t\t{ value: roundValueAuto(d.adjusted_p_value) }\n\t\t\t\t]\n\t\t\t\tif (this.termType == DNA_METHYLATION) {\n\t\t\t\t\trow.splice(0, 0, { value: d.promoter_id || '' }, { value: d.gene_name || '' })\n\t\t\t\t} else {\n\t\t\t\t\trow.splice(0, 0, { value: d.gene_name || '' })\n\t\t\t\t}\n\t\t\t\t//Do not create p-value table data unless user opts to show the table\n\t\t\t\tif (this.settings.showPValueTable) this.pValueTable.rows.push(row)\n\t\t\t} else {\n\t\t\t\tthis.numNonSignificant++\n\t\t\t}\n\t\t\td.x = plotDim.xScale.scale(d.fold_change) + this.plotX\n\t\t\tconst y =\n\t\t\t\td[`${this.settings.pValueType}_p_value`] == 0 ? this.minNonZeroPValue : d[`${this.settings.pValueType}_p_value`]\n\t\t\td.y = plotDim.yScale.scale(-Math.log10(y)) + this.topPad\n\t\t\td.radius = radius\n\t\t}\n\t\t// Use the server's pre-truncation count so stats are correct even when\n\t\t// dots was capped by maxInteractiveDots.\n\t\tthis.numSignificant = this.response.data.totalSignificantRows\n\t\tthis.numNonSignificant = Math.max(0, this.response.data.totalRows - this.numSignificant)\n\t\t//Sort so the highlighted points appear on top\n\t\tdataCopy.sort((a: any, b: any) => a.highlighted - b.highlighted)\n\t\treturn dataCopy\n\t}\n\n\tgetGenesColor(d: DataPointEntry, significant: boolean, controlColor: string, caseColor: string) {\n\t\tif (!d.gene_name && this.termType != DNA_METHYLATION)\n\t\t\tthrow new Error(`Missing gene_name in data: ${JSON.stringify(d)}`)\n\t\tif (significant) {\n\t\t\tif (controlColor && caseColor) d.color = d.fold_change > 0 ? caseColor : controlColor\n\t\t\telse d.color = this.settings.defaultSignColor\n\t\t} else d.color = this.settings.defaultNonSignColor\n\t}\n\n\tsetStatsData() {\n\t\tconst tableRows = [\n\t\t\t{\n\t\t\t\tlabel: `Percentage of significant ${this.dataType}`,\n\t\t\t\tvalue: roundValueAuto((this.numSignificant * 100) / (this.numSignificant + this.numNonSignificant))\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: `Number of significant ${this.dataType}`,\n\t\t\t\tvalue: this.numSignificant\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: `Number of total ${this.dataType}`,\n\t\t\t\tvalue: this.numSignificant + this.numNonSignificant\n\t\t\t}\n\t\t]\n\t\tif (this.termType == GENE_EXPRESSION || this.termType == DNA_METHYLATION) {\n\t\t\ttableRows.push(\n\t\t\t\t{\n\t\t\t\t\tlabel: this.config.samplelst.groups[0].name + ' sample size (control group)',\n\t\t\t\t\tvalue: this.response.sample_size1\n\t\t\t\t},\n\t\t\t\t{\n\t\t\t\t\tlabel: this.config.samplelst.groups[1].name + ' sample size (case group)',\n\t\t\t\t\tvalue: this.response.sample_size2\n\t\t\t\t}\n\t\t\t)\n\t\t}\n\n\t\tif (this.response.bcv !== undefined && this.response.bcv !== null) {\n\t\t\ttableRows.push({\n\t\t\t\tlabel: 'Biological coefficient of variation',\n\t\t\t\tvalue: roundValueAuto(this.response.bcv)\n\t\t\t})\n\t\t}\n\t\treturn tableRows\n\t}\n\n\tsetPTableColumns() {\n\t\tif (this.termType == DNA_METHYLATION) {\n\t\t\tthis.pValueTable.columns.splice(0, 0, { label: 'Promoter', sortable: true }, { label: 'Gene(s)', sortable: true })\n\t\t} else {\n\t\t\tthis.pValueTable.columns.splice(0, 0, { label: 'Gene Name', sortable: true })\n\t\t}\n\t}\n\n\tsetUserActions() {\n\t\tconst userActions = {\n\t\t\tnoShow: new Set<string>()\n\t\t}\n\t\tif (this.termType == GENE_EXPRESSION) {\n\t\t\tif (this.settings.method == 'edgeR' && getSampleNum(this.config) > 100) {\n\t\t\t\tuserActions.noShow.add('Confounding factors')\n\t\t\t}\n\t\t\tif (this.settings.method == 'wilcoxon') userActions.noShow.add('Confounding factors')\n\t\t}\n\t\treturn userActions\n\t}\n}\n", "import type { MassAppApi } from '#mass/types/mass'\nimport { downloadTable, GeneSetEditUI, MultiTermWrapperEditUI } from '#dom'\nimport { to_svg } from '#src/client'\nimport type { VolcanoDom, VolcanoPlotConfig } from '../VolcanoTypes'\nimport { DNA_METHYLATION, GENE_EXPRESSION } from '#shared/terms.js'\nimport { getGEunit } from '#tw/geneExpression'\n\nexport class VolcanoInteractions {\n\tapp: MassAppApi\n\tdom: VolcanoDom\n\tid: string\n\tpValueTableData: any\n\tdata: any\n\n\tconstructor(app: MassAppApi, id: string, dom: VolcanoDom) {\n\t\tthis.app = app\n\t\tthis.dom = dom\n\t\tthis.id = id\n\t\tthis.pValueTableData = []\n\t\tthis.data = []\n\t}\n\n\t/** Launches a multi-term select tree\n\t * On submit, dispatches a plot_edit action with the new confounders */\n\tasync confoundersMenu() {\n\t\tconst state = this.app.getState()\n\t\tconst config = state.plots.find((p: VolcanoPlotConfig) => p.id === this.id)\n\t\tif (config.termType !== GENE_EXPRESSION && config.termType !== DNA_METHYLATION) return\n\n\t\t/** Find terms used to create the groups and disable in the\n\t\t * termsetting UI. Prevents users from trying to control for\n\t\t * variables used to create the groups.*/\n\t\tconst allowedGroupNames = new Set([config.samplelst.groups[0].name, config.samplelst.groups[1].name])\n\t\tconst grpTerms: Set<string> = new Set(\n\t\t\t(this.app?.vocabApi?.state.groups || [])\n\t\t\t\t.filter(g => allowedGroupNames.has(g.name))\n\t\t\t\t.flatMap(g =>\n\t\t\t\t\tg.filter.lst.flatMap(f => {\n\t\t\t\t\t\tif (f.tvs?.term) return f.tvs.term\n\t\t\t\t\t\telse return f.lst.map(l => l.tvs.term)\n\t\t\t\t\t})\n\t\t\t\t)\n\t\t)\n\t\tconst disable_terms: any[] = grpTerms.size ? Array.from(grpTerms) : []\n\t\tconst maxNum = config.settings.volcano.method == 'edgeR' ? 1 : 2\n\n\t\tconst ui = new MultiTermWrapperEditUI({\n\t\t\tapp: this.app,\n\t\t\tcallback: async (tws: any) => {\n\t\t\t\tthis.dom.actionsTip.hide()\n\t\t\t\tawait this.app.dispatch({\n\t\t\t\t\ttype: 'plot_edit',\n\t\t\t\t\tid: this.id,\n\t\t\t\t\tconfig: { confounderTws: tws }\n\t\t\t\t})\n\t\t\t},\n\t\t\tholder: this.dom.actionsTip.d as any,\n\t\t\theaderText: 'Select confounders',\n\t\t\tmaxNum,\n\t\t\tstate,\n\t\t\ttwList: config.confounderTws,\n\t\t\tdisable_terms\n\t\t})\n\t\tawait ui.renderUI()\n\t}\n\n\tdownload(termType: string) {\n\t\tthis.dom.actionsTip.clear().showunder(this.dom.controls.select('div').node())\n\t\tconst opts = [\n\t\t\t{\n\t\t\t\ttext: 'Download plot',\n\t\t\t\tcallback: () => {\n\t\t\t\t\tconst svg = this.dom.holder.select('svg').node() as Node\n\t\t\t\t\tto_svg(svg, `Differential ${termType} analysis volcano`, { apply_dom_styles: true })\n\t\t\t\t}\n\t\t\t},\n\t\t\t{\n\t\t\t\ttext: 'Download p value table',\n\t\t\t\tcallback: () => {\n\t\t\t\t\tdownloadTable(this.pValueTableData.rows, this.pValueTableData.columns)\n\t\t\t\t}\n\t\t\t}\n\t\t]\n\t\tfor (const opt of opts) {\n\t\t\tthis.dom.actionsTip.d.append('div').attr('class', 'sja_menuoption').text(opt.text).on('click', opt.callback)\n\t\t}\n\t}\n\n\tasync highlightDataPoint(value: string) {\n\t\tconst config = this.app.getState().plots.find((p: VolcanoPlotConfig) => p.id === this.id)\n\t\tconst highlightedData = config.highlightedData.includes(value)\n\t\t\t? config.highlightedData.filter(d => d !== value)\n\t\t\t: [...config.highlightedData, value]\n\t\tawait this.app.dispatch({\n\t\t\ttype: 'plot_edit',\n\t\t\tid: this.id,\n\t\t\tconfig: { highlightedData }\n\t\t})\n\t}\n\n\t/** When clicking on a data point, launches the box plot in a separate sandbox\n\t * For geneExpression, value == gene symbol */\n\tlaunchBoxPlot(value: string) {\n\t\tconst config = this.app.getState().plots.find((p: VolcanoPlotConfig) => p.id === this.id)\n\t\tconst values = {}\n\t\tfor (const group of config.samplelst.groups) {\n\t\t\tvalues[group.name] = {\n\t\t\t\tkey: group.name,\n\t\t\t\tlabel: group.name,\n\t\t\t\tlist: group.values\n\t\t\t}\n\t\t}\n\t\t/** Gene variant and expression terms do not have an id\n\t\t * need to be handled separately.\n\t\t * TODO: In the future with more use cases, simplify this logic. */\n\t\tconst setTerm = () => {\n\t\t\tif (config.termType == GENE_EXPRESSION) {\n\t\t\t\treturn {\n\t\t\t\t\tq: { mode: 'continuous' },\n\t\t\t\t\tterm: {\n\t\t\t\t\t\tgene: value,\n\t\t\t\t\t\tname: value,\n\t\t\t\t\t\ttype: config.termType\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t} else return config.term\n\t\t}\n\t\tthis.app.dispatch({\n\t\t\ttype: 'plot_create',\n\t\t\tconfig: {\n\t\t\t\tchartType: 'summary',\n\t\t\t\tchildType: 'boxplot',\n\t\t\t\tterm: setTerm(),\n\t\t\t\tterm2: {\n\t\t\t\t\tq: { groups: config.tw.q.groups, type: 'custom-samplelst' },\n\t\t\t\t\tterm: config.tw.term\n\t\t\t\t}\n\t\t\t}\n\t\t})\n\t}\n\n\t/** Launch a violin plot for a gene expression data point. */\n\tlaunchViolinGeneExp(value: string) {\n\t\tconst config = this.app.getState().plots.find((p: VolcanoPlotConfig) => p.id === this.id)\n\t\tthis.app.dispatch({\n\t\t\ttype: 'plot_create',\n\t\t\tconfig: {\n\t\t\t\tchartType: 'summary',\n\t\t\t\tchildType: 'violin',\n\t\t\t\tterm: {\n\t\t\t\t\tq: { mode: 'continuous' },\n\t\t\t\t\tterm: {\n\t\t\t\t\t\tgene: value,\n\t\t\t\t\t\tname: value,\n\t\t\t\t\t\ttype: config.termType\n\t\t\t\t\t}\n\t\t\t\t},\n\t\t\t\tterm2: {\n\t\t\t\t\tq: { groups: config.tw.q.groups, type: 'custom-samplelst' },\n\t\t\t\t\tterm: config.tw.term\n\t\t\t\t}\n\t\t\t}\n\t\t})\n\t}\n\n\tlaunchGeneSetEdit() {\n\t\tconst plotConfig = this.app.getState().plots.find((p: VolcanoPlotConfig) => p.id === this.id)\n\t\tconst holder = this.dom.actionsTip.d.append('div').style('padding', '5px') as any\n\t\tconst limitedGenesList =\n\t\t\tplotConfig.termType === DNA_METHYLATION ? this.data.map(d => d.promoter_id) : this.data.map(d => d.gene_name)\n\t\tnew GeneSetEditUI({\n\t\t\tholder,\n\t\t\tgenome: this.app.opts.genome,\n\t\t\tvocabApi: this.app.vocabApi,\n\t\t\tlimitedGenesList,\n\t\t\tgeneList: plotConfig.highlightedData.map(d => {\n\t\t\t\treturn { gene: d } //Formatted to Gene type in GeneSetEditUI\n\t\t\t}),\n\t\t\tcustomInputs: [\n\t\t\t\t{\n\t\t\t\t\tlabel: 'Cancel highlight',\n\t\t\t\t\tgetDisplayStyle: () => (plotConfig.highlightedData.length > 0 ? '' : 'none'),\n\t\t\t\t\tshowInput: async () => {\n\t\t\t\t\t\tawait this.app.dispatch({\n\t\t\t\t\t\t\ttype: 'plot_edit',\n\t\t\t\t\t\t\tid: this.id,\n\t\t\t\t\t\t\tconfig: { highlightedData: [] }\n\t\t\t\t\t\t})\n\t\t\t\t\t\tthis.dom.actionsTip.hide()\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t],\n\t\t\tcallback: async result => {\n\t\t\t\tconst highlightedData = result.geneList.map(d => d.gene)\n\t\t\t\tawait this.app.dispatch({\n\t\t\t\t\ttype: 'plot_edit',\n\t\t\t\t\tid: this.id,\n\t\t\t\t\tconfig: { highlightedData }\n\t\t\t\t})\n\t\t\t\tthis.dom.actionsTip.hide()\n\t\t\t}\n\t\t})\n\t}\n\n\t/** When clicking on a DM data point, dispatches a DMR plot that runs DMRCate\n\t * analysis and renders a genome browser Block with DMR regions on their own\n\t * track. */\n\tasync launchDmr(d: { chr: string; start: number; stop: number; promoterId?: string }) {\n\t\tconst config = this.app.getState().plots.find((p: VolcanoPlotConfig) => p.id === this.id)\n\n\t\tconst controlColor = config?.tw?.term?.values?.[config?.samplelst?.groups[0].name]?.color || '#ff0000'\n\t\tconst caseColor = config?.tw?.term?.values?.[config?.samplelst?.groups[1].name]?.color || '#0000ff'\n\n\t\tconst label = d.promoterId || `${d.chr}:${d.start}-${d.stop}`\n\t\tconst dmrConfig: any = {\n\t\t\tchartType: 'dmr',\n\t\t\theaderText: `DMR: ${label}`,\n\t\t\tcoordinateOverride: { chr: d.chr, start: d.start, stop: d.stop },\n\t\t\tgroup1: config.samplelst.groups[0].values || [],\n\t\t\tgroup2: config.samplelst.groups[1].values || [],\n\t\t\tgroup1Name: config.samplelst.groups[0].name,\n\t\t\tgroup2Name: config.samplelst.groups[1].name,\n\t\t\tsettings: {\n\t\t\t\tcolors: { group1: controlColor, group2: caseColor }\n\t\t\t}\n\t\t}\n\n\t\tthis.app.dispatch({\n\t\t\ttype: 'plot_create',\n\t\t\tconfig: dmrConfig\n\t\t})\n\t}\n\n\t/** Launch a violin/box plot for a DNA methylation promoter.\n\t * Creates a methylation term using the promoter's chr/start/stop coordinates.\n\t * The tw handler fills in id and unit from termdbConfig. */\n\tlaunchDNAMethViolin(d: { chr: string; start: number; stop: number; gene_name?: string; promoter_id?: string }) {\n\t\tconst config = this.app.getState().plots.find((p: VolcanoPlotConfig) => p.id === this.id)\n\t\tconst genomicFeatureType = d.promoter_id ? 'promoter' : 'gene'\n\t\tconst featureName = genomicFeatureType === 'gene' ? d.gene_name?.split(',')[0]?.trim() || '' : ''\n\t\tthis.app.dispatch({\n\t\t\ttype: 'plot_create',\n\t\t\tconfig: {\n\t\t\t\tchartType: 'summary',\n\t\t\t\tchildType: 'violin',\n\t\t\t\tterm: {\n\t\t\t\t\tq: { mode: 'continuous' },\n\t\t\t\t\tterm: {\n\t\t\t\t\t\tgenomicFeatureType,\n\t\t\t\t\t\tfeatureName,\n\t\t\t\t\t\ttype: DNA_METHYLATION,\n\t\t\t\t\t\tchr: d.chr,\n\t\t\t\t\t\tstart: d.start,\n\t\t\t\t\t\tstop: d.stop\n\t\t\t\t\t}\n\t\t\t\t},\n\t\t\t\tterm2: {\n\t\t\t\t\tq: { groups: config.tw.q.groups, type: 'custom-samplelst' },\n\t\t\t\t\tterm: config.tw.term\n\t\t\t\t}\n\t\t\t}\n\t\t})\n\t}\n\n\tasync launchDEGClustering() {\n\t\t//Sort the DEG rows by q-value in ascending order\n\t\tconst geneIndex = this.pValueTableData.columns.findIndex(col => col.label === 'Gene Name')\n\t\tconst adjustedPValIndex = this.pValueTableData.columns.findIndex(col => col.label === 'Adjusted p-value')\n\t\tconst rowsSorted = [...this.pValueTableData.rows].sort((a, b) => {\n\t\t\tconst aQVal = Number(a[adjustedPValIndex].value)\n\t\t\tconst bQVal = Number(b[adjustedPValIndex].value)\n\t\t\treturn aQVal - bQVal\n\t\t})\n\n\t\t// Launch hierCluster for up to 100 DEGs with the smallest q-values\n\t\tconst geneList = rowsSorted.slice(0, 100).map(r => ({ gene: r[geneIndex].value }))\n\n\t\tconst tws = geneList.map(d => {\n\t\t\tconst gene = d.gene\n\t\t\tconst unit = getGEunit(this.app.vocabApi)\n\t\t\tconst name = `${gene} ${unit}`\n\t\t\tconst term = { gene, name, type: GENE_EXPRESSION }\n\t\t\treturn { term, q: {} }\n\t\t})\n\n\t\tconst group = { lst: tws, type: 'hierCluster' }\n\t\tconst customVariable = this.app.getState().plots.find((p: any) => p.id === this.id).tw\n\t\tconst annotationGroup = { lst: [customVariable] }\n\t\tconst config = {\n\t\t\tchartType: 'hierCluster',\n\t\t\ttermgroups: [group, annotationGroup],\n\t\t\tdataType: GENE_EXPRESSION,\n\t\t\tfilter: {\n\t\t\t\tin: true,\n\t\t\t\tjoin: '',\n\t\t\t\ttype: 'tvslst',\n\t\t\t\tlst: [{ type: 'tvs', tvs: { term: customVariable.term } }]\n\t\t\t}\n\t\t}\n\t\tawait this.app.dispatch({\n\t\t\ttype: 'plot_create',\n\t\t\tconfig: structuredClone(config)\n\t\t})\n\t}\n}\n", "import { table2col, type Menu } from '#dom'\nimport { roundValueAuto } from '#shared/roundValue.js'\nimport type { SvgCircle } from '../../../types/d3'\nimport type { VolcanoInteractions } from '../interactions/VolcanoInteractions'\nimport type { DataPointEntry } from '../VolcanoTypes'\nimport { DNA_METHYLATION, GENE_EXPRESSION } from '#shared/terms.js'\n\nexport class DataPointMouseEvents {\n\ttermType: string\n\n\tconstructor(d: DataPointEntry, circle: SvgCircle, tip: Menu, interactions: VolcanoInteractions, termType: string) {\n\t\tthis.termType = termType\n\n\t\tconst menuOpts = [\n\t\t\t{\n\t\t\t\tlabel: 'Violin plot',\n\t\t\t\tisVisible: () => {\n\t\t\t\t\tconst enabledTermTypes = new Set([DNA_METHYLATION, GENE_EXPRESSION])\n\t\t\t\t\treturn enabledTermTypes.has(termType)\n\t\t\t\t},\n\t\t\t\tonClick: async () => {\n\t\t\t\t\tif (termType === DNA_METHYLATION) interactions.launchDNAMethViolin(d as any)\n\t\t\t\t\tif (termType === GENE_EXPRESSION) interactions.launchViolinGeneExp(d.gene_name)\n\t\t\t\t}\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'DMR analysis',\n\t\t\t\tisVisible: () => termType === DNA_METHYLATION,\n\t\t\t\tonClick: async () => {\n\t\t\t\t\tconst dm = d as DataPointEntry & {\n\t\t\t\t\t\tchr: string\n\t\t\t\t\t\tstart: number\n\t\t\t\t\t\tstop: number\n\t\t\t\t\t\tpromoter_id?: string\n\t\t\t\t\t\tgene_name?: string\n\t\t\t\t\t}\n\t\t\t\t\tawait interactions.launchDmr({\n\t\t\t\t\t\tchr: dm.chr,\n\t\t\t\t\t\tstart: dm.start,\n\t\t\t\t\t\tstop: dm.stop,\n\t\t\t\t\t\tpromoterId: dm.promoter_id\n\t\t\t\t\t})\n\t\t\t\t}\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Box plot',\n\t\t\t\tisVisible: () => termType === GENE_EXPRESSION,\n\t\t\t\tonClick: async () => {\n\t\t\t\t\tinteractions.launchBoxPlot(d.gene_name)\n\t\t\t\t}\n\t\t\t}\n\t\t]\n\n\t\t// Use a throwaway clone to visualize the hover highlight instead of mutating\n\t\t// the original circle + raising it. Rearranging DOM mid-hover can leave the\n\t\t// original stuck at full fill-opacity when rapid enter/leave events race\n\t\t// against the DOM move. Same pattern as the p-value table hover preview.\n\t\tlet clone: SVGCircleElement | null = null\n\t\tconst showHighlight = () => {\n\t\t\tif (clone) return\n\t\t\tconst node = circle.node() as SVGCircleElement | null\n\t\t\tif (!node) return\n\t\t\tconst c = node.cloneNode(true) as SVGCircleElement\n\t\t\tc.setAttribute('fill-opacity', '0.9')\n\t\t\t// Don't intercept subsequent enter/leave events destined for siblings.\n\t\t\tc.setAttribute('pointer-events', 'none')\n\t\t\tnode.parentNode?.appendChild(c)\n\t\t\tclone = c\n\t\t}\n\t\tconst hideHighlight = () => {\n\t\t\tif (!clone) return\n\t\t\tclone.remove()\n\t\t\tclone = null\n\t\t}\n\n\t\tcircle.on('mouseenter', () => {\n\t\t\t// Skip the clone for already-highlighted points; their fill handles the visual.\n\t\t\tif (!d.highlighted) showHighlight()\n\t\t\ttip.clear().showunder(circle.node())\n\t\t\tconst table = table2col({ holder: tip.d.append('table') })\n\t\t\tthis.addTooltipRows(d, table)\n\t\t})\n\n\t\tlet menuOpen = false\n\t\tcircle.on('mouseleave', () => {\n\t\t\tif (menuOpen) return\n\t\t\ttip.hide()\n\t\t\thideHighlight()\n\t\t})\n\n\t\tconst visibleMenuOpts = menuOpts.filter(opt => opt.isVisible())\n\t\tif (visibleMenuOpts.length === 0) return\n\n\t\tcircle.on('click', () => {\n\t\t\tmenuOpen = true\n\t\t\tif (!d.highlighted) showHighlight()\n\t\t\ttip.onHide = () => {\n\t\t\t\tmenuOpen = false\n\t\t\t\thideHighlight()\n\t\t\t}\n\t\t\ttip.clear().showunder(circle.node())\n\t\t\tfor (const opt of visibleMenuOpts) {\n\t\t\t\ttip.d\n\t\t\t\t\t.append('div')\n\t\t\t\t\t.attr('class', 'sja_menuoption')\n\t\t\t\t\t.text(opt.label)\n\t\t\t\t\t.on('click', async () => {\n\t\t\t\t\t\ttip.hide()\n\t\t\t\t\t\thideHighlight()\n\t\t\t\t\t\tawait opt.onClick()\n\t\t\t\t\t})\n\t\t\t}\n\t\t})\n\t}\n\n\taddTooltipRows(d: DataPointEntry, table: any) {\n\t\tif (this.termType === DNA_METHYLATION) {\n\t\t\tif ('promoter_id' in d) this.addTooltipRow(table, 'Promoter', d.promoter_id)\n\t\t\tif (d.gene_name) this.addTooltipRow(table, 'Gene(s)', d.gene_name)\n\t\t} else {\n\t\t\tthis.addTooltipRow(table, 'Gene name', d.gene_name)\n\t\t}\n\t\tthis.addTooltipRow(table, 'log<sub>2</sub>(fold-change)', roundValueAuto(d.fold_change))\n\t\tthis.addTooltipRow(table, 'Original p-value', roundValueAuto(d.original_p_value))\n\t\tthis.addTooltipRow(table, 'Adjusted p-value', roundValueAuto(d.adjusted_p_value))\n\t}\n\n\taddTooltipRow(table: any, text: string, value: number | string) {\n\t\tconst [td1, td2] = table.addRow()\n\t\ttd1.html(text)\n\t\ttd2.text(value)\n\t}\n}\n", "import { axisBottom, axisLeft } from 'd3-axis'\nimport { axisstyle, table2col, renderTable } from '#dom'\nimport { select, selectAll } from 'd3-selection'\nimport { rgb } from 'd3-color'\nimport type { DataPointEntry, VolcanoDom, VolcanoPlotDimensions, VolcanoViewData } from '../VolcanoTypes'\nimport type { VolcanoPlotDom } from './VolcanoPlotDom'\nimport type { VolcanoInteractions } from '../interactions/VolcanoInteractions'\nimport { DataPointMouseEvents } from './DataPointMouseEvents'\nimport { DNA_METHYLATION, GENE_EXPRESSION, SINGLECELL_CELLTYPE } from '#shared/terms.js'\nimport type { ValidatedVolcanoSettings } from '../settings/Settings'\n\nexport class VolcanoPlotView {\n\tdom: VolcanoDom\n\tinteractions: VolcanoInteractions\n\tsettings: any\n\ttermType: string\n\tvolcanoDom: VolcanoPlotDom\n\tviewData!: VolcanoViewData\n\n\tconstructor(dom: VolcanoDom, interactions: VolcanoInteractions, termType: string) {\n\t\tthis.dom = dom\n\t\tthis.interactions = interactions\n\t\tthis.termType = termType\n\t\tconst actions = this.dom.holder\n\t\t\t.append('div')\n\t\t\t.attr('id', 'sjpp-volcano-actions')\n\t\t\t.style('display', 'block')\n\t\t\t.style('z-index', 1)\n\t\t\t.style('position', 'relative')\n\t\tconst svg = this.dom.holder\n\t\t\t.append('svg')\n\t\t\t.style('display', 'inline-block')\n\t\t\t.attr('id', 'sjpp-volcano-svg')\n\t\t\t.style('vertical-align', 'top')\n\t\tthis.volcanoDom = {\n\t\t\tactions,\n\t\t\tsvg,\n\t\t\tpValueTable: undefined,\n\t\t\ttop: undefined,\n\t\t\txAxis: undefined,\n\t\t\txAxisLabel: undefined,\n\t\t\tyAxis: undefined,\n\t\t\tyAxisLabel: undefined,\n\t\t\tplot: undefined\n\t\t} as Partial<VolcanoPlotDom> as VolcanoPlotDom\n\t}\n\n\trender(settings: ValidatedVolcanoSettings, viewData: VolcanoViewData) {\n\t\tthis.settings = settings\n\t\tthis.viewData = viewData\n\t\tconst plotDim = this.viewData.plotDim\n\n\t\tthis.initDom()\n\n\t\tthis.renderUserActions()\n\t\tthis.renderPlot(plotDim)\n\t\trenderDataPoints(this)\n\t\tthis.renderFoldChangeLine(plotDim)\n\t\tif (this.settings.showPValueTable) this.renderPValueTable()\n\t}\n\n\tinitDom() {\n\t\tthis.volcanoDom.actions.selectAll('*').remove()\n\t\tthis.volcanoDom.svg.selectAll('*').remove()\n\n\t\tconst svg = this.volcanoDom.svg\n\t\tthis.volcanoDom.top = svg.append('g').attr('id', 'sjpp-volcano-top')\n\t\tthis.volcanoDom.xAxis = svg.append('g').attr('id', 'sjpp-volcano-xAxis')\n\t\tthis.volcanoDom.yAxis = svg.append('g').attr('id', 'sjpp-volcano-yAxis')\n\t\tthis.volcanoDom.xAxisLabel = svg.append('text').attr('id', 'sjpp-volcano-xAxisLabel').attr('text-anchor', 'middle')\n\t\tthis.volcanoDom.yAxisLabel = svg.append('text').attr('id', 'sjpp-volcano-yAxisLabel').attr('text-anchor', 'middle')\n\t\tthis.volcanoDom.plot = svg.append('g').attr('id', 'sjpp-volcano-plot')\n\n\t\tif (!this.settings.showPValueTable) return\n\t\tthis.volcanoDom.pValueTable = this.dom.holder\n\t\t\t.append('div')\n\t\t\t.attr('id', 'sjpp-volcano-pValueTable')\n\t\t\t.attr('data-testid', 'sjpp-volcano-pValueTable')\n\t\t\t.style('display', 'inline-block')\n\t\t\t.style('vertical-align', 'top')\n\t}\n\n\trenderUserActions() {\n\t\t//Images may have a large margin. Hide the overflow.\n\t\tthis.dom.actionsTip.d.style('overflow', 'hidden')\n\t\tthis.volcanoDom.actions.style('margin-left', '20px').style('padding', '5px')\n\t\tthis.addActionButton('Confounding factors', [GENE_EXPRESSION, DNA_METHYLATION], () =>\n\t\t\tthis.interactions.confoundersMenu()\n\t\t)\n\t\tthis.addActionButton('Highlight genes', [GENE_EXPRESSION, SINGLECELL_CELLTYPE, DNA_METHYLATION], () =>\n\t\t\tthis.interactions.launchGeneSetEdit()\n\t\t)\n\t\tthis.addActionButton('Statistics', [GENE_EXPRESSION, SINGLECELL_CELLTYPE, DNA_METHYLATION], () => {\n\t\t\tthis.renderStatsMenu()\n\t\t})\n\t\tconst sigLabel =\n\t\t\tthis.termType == DNA_METHYLATION ? 'Number of significant promoters' : 'Number of significant genes'\n\t\tconst numSigGenes = this.viewData.statsData.find(d => d.label == sigLabel)?.value\n\t\tif (numSigGenes) {\n\t\t\tconst sigText = this.termType == DNA_METHYLATION ? `${numSigGenes} DM promoters:` : `${numSigGenes} DE genes:`\n\t\t\tthis.volcanoDom.actions.append('span').text(sigText).style('margin-left', '10px').style('font-weight', 'bold')\n\n\t\t\tthis.addActionButton('Show p-value table', [GENE_EXPRESSION, SINGLECELL_CELLTYPE, DNA_METHYLATION], async () => {\n\t\t\t\t/** TODO: This is very slow to render. Need to optimize rendering\n\t\t\t\t * and server response to increase performance.*/\n\t\t\t\tconst showTable = !this.settings.showPValueTable\n\t\t\t\tawait this.interactions.app.dispatch({\n\t\t\t\t\ttype: 'plot_edit',\n\t\t\t\t\tid: this.interactions.id,\n\t\t\t\t\tconfig: { settings: { volcano: { showPValueTable: showTable } } }\n\t\t\t\t})\n\t\t\t})\n\t\t}\n\t\tif (numSigGenes && numSigGenes >= 3) {\n\t\t\t// Launch hierCluster for DEGs between the two groups\n\t\t\tthis.addActionButton(\n\t\t\t\t`Hierarchical clustering of ${numSigGenes > 100 ? 'top 100' : numSigGenes} DE genes`,\n\t\t\t\t[GENE_EXPRESSION],\n\t\t\t\tasync () => {\n\t\t\t\t\tawait this.interactions.launchDEGClustering()\n\t\t\t\t}\n\t\t\t)\n\t\t}\n\t}\n\n\t/** Use the termTypes arr to render the buttons in a consistent order */\n\taddActionButton(text: string, termTypes: string[], callback: any) {\n\t\tif (this.viewData.userActions.noShow.has(text)) return\n\t\tif (!termTypes.includes(this.termType)) return\n\t\tconst button = this.volcanoDom.actions\n\t\t\t.append('button')\n\t\t\t.attr('class', 'sja_menuoption')\n\t\t\t.style('margin', '3px')\n\t\t\t.style('padding', '3px')\n\t\t\t.text(text)\n\t\t\t.on('click', async () => {\n\t\t\t\tthis.dom.actionsTip.clear().showunder(button.node())\n\t\t\t\tawait callback()\n\t\t\t})\n\t}\n\n\trenderPlot(plotDim: VolcanoPlotDimensions) {\n\t\tthis.volcanoDom.svg.attr('width', plotDim.svg.width).attr('height', plotDim.svg.height)\n\n\t\tthis.renderTermInfo(plotDim)\n\n\t\tthis.volcanoDom.yAxisLabel.attr(\n\t\t\t'transform',\n\t\t\t`translate(${plotDim.yAxisLabel.x}, ${plotDim.yAxisLabel.y}) rotate(-90)`\n\t\t)\n\t\tthis.setSvgSubscriptLabel(this.volcanoDom.yAxisLabel, '-log', '10', `(${this.settings.pValueType} p-value)`)\n\n\t\tthis.volcanoDom.xAxisLabel.attr('transform', `translate(${plotDim.xAxisLabel.x}, ${plotDim.xAxisLabel.y})`)\n\t\tthis.setSvgSubscriptLabel(this.volcanoDom.xAxisLabel, 'log', '2', '(fold-change)')\n\n\t\tthis.renderScale(plotDim.xScale)\n\t\tthis.renderScale(plotDim.yScale, true)\n\n\t\t// Server-rendered PNG of the full scatter (every dot, non-interactive).\n\t\t// Drawn first so overlay circles + the border rect sit on top. The volcano\n\t\t// binary emits a borderless image whose data extent matches the client's\n\t\t// scales, so placing it over the plot rect aligns dot-for-dot.\n\t\tif (this.viewData.volcanoPng) {\n\t\t\tthis.volcanoDom.plot\n\t\t\t\t.append('image')\n\t\t\t\t.attr('href', `data:image/png;base64,${this.viewData.volcanoPng}`)\n\t\t\t\t.attr('x', plotDim.plot.x)\n\t\t\t\t.attr('y', plotDim.plot.y)\n\t\t\t\t.attr('width', plotDim.plot.width)\n\t\t\t\t.attr('height', plotDim.plot.height)\n\t\t\t\t.attr('preserveAspectRatio', 'none')\n\t\t}\n\n\t\tthis.volcanoDom.plot\n\t\t\t.append('rect')\n\t\t\t.attr('width', plotDim.plot.width)\n\t\t\t.attr('height', plotDim.plot.height)\n\t\t\t.attr('stroke', '#ededed')\n\t\t\t.attr('fill', 'transparent')\n\t\t\t.attr('shape-rendering', 'crispEdges')\n\t\t\t.attr('transform', `translate(${plotDim.plot.x}, ${plotDim.plot.y})`)\n\t}\n\n\trenderTermInfo(plotDim) {\n\t\tif (this.viewData.termInfo == undefined) return\n\t\tthis.volcanoDom.top.attr('transform', `translate(${plotDim.top.x}, ${plotDim.top.y})`)\n\n\t\tconst y = this.viewData.termInfo.y\n\t\tconst addLabel = term => {\n\t\t\treturn (\n\t\t\t\tthis.volcanoDom.top\n\t\t\t\t\t.append('text')\n\t\t\t\t\t.attr('font-size', '0.9em')\n\t\t\t\t\t.attr('transform', `translate(${term.x}, ${y + 10})`)\n\t\t\t\t\t// .attr('text-anchor', 'start')\n\t\t\t\t\t.text(term.label)\n\t\t\t)\n\t\t}\n\n\t\t// const addRect = (term) => {\n\t\t// \tthis.volcanoDom.top.append('rect')\n\t\t// \t\t.attr('width', 10)\n\t\t// \t\t.attr('height', 10)\n\t\t// \t\t.attr('transform', `translate(${term.rectX}, ${y})`)\n\t\t// \t\t.attr('fill', term.color)\n\t\t// }\n\n\t\tconst firstTerm = this.viewData.termInfo.first\n\t\taddLabel(firstTerm)\n\t\t// addRect(firstTerm)\n\n\t\tconst secondTerm = this.viewData.termInfo.second\n\t\t// addRect(secondTerm)\n\t\tconst secondLabel = addLabel(secondTerm)\n\t\tsecondLabel.attr('text-anchor', 'end')\n\t}\n\n\trenderScale(scale: any, isLeft = false) {\n\t\tconst scaleG = this.volcanoDom[isLeft ? 'yAxis' : 'xAxis']\n\t\t\t.append('g')\n\t\t\t.attr('transform', `translate(${scale.x}, ${scale.y})`)\n\t\t\t.call(isLeft ? axisLeft(scale.scale) : axisBottom(scale.scale))\n\n\t\taxisstyle({\n\t\t\taxis: scaleG,\n\t\t\tcolor: 'black',\n\t\t\tshowline: true\n\t\t})\n\t}\n\n\trenderFoldChangeLine(plotDim: VolcanoPlotDimensions) {\n\t\t//logFoldChangeLine\n\t\tthis.volcanoDom.plot\n\t\t\t.append('line')\n\t\t\t.attr('stroke', '#ccc')\n\t\t\t.attr('shape-rendering', 'crispEdges')\n\t\t\t.attr('x1', plotDim.logFoldChangeLine.x)\n\t\t\t.attr('x2', plotDim.logFoldChangeLine.x)\n\t\t\t.attr('y1', plotDim.logFoldChangeLine.y1)\n\t\t\t.attr('y2', plotDim.logFoldChangeLine.y2)\n\t}\n\n\trenderStatsMenu() {\n\t\t//Render any images. viewModel returns the response array of images or []\n\t\tfor (const img of this.viewData.images || []) {\n\t\t\tthis.dom.actionsTip.d\n\t\t\t\t.append('img')\n\t\t\t\t.style('display', 'inline-block')\n\t\t\t\t.style('margin-left', '10px')\n\t\t\t\t.style('margin-top', '-30px')\n\t\t\t\t.attr('width', 450)\n\t\t\t\t.attr('height', 450)\n\t\t\t\t.attr('src', img.src)\n\t\t}\n\t\tconst tableHolder = this.dom.actionsTip.d\n\t\t\t.append('div')\n\t\t\t//Show the stats table underneath the images if > 1 image or to the right if only 1 image\n\t\t\t.style('display', this.viewData.images.length == 1 ? 'inline-block' : 'block')\n\t\t\t//Top margin is roughly inline with image however the margins are set by server\n\t\t\t//Likewise the image margins are undetectable.\n\t\t\t//This is a roughly satistifes the different image margin scenarios.\n\t\t\t.style('margin', `${this.viewData.images.length == 1 ? `40px 10px` : `0px 0px`} 0px 5px`)\n\t\t\t.style('vertical-align', 'top')\n\t\tconst table = table2col({ holder: tableHolder })\n\t\tfor (const d of this.viewData.statsData) {\n\t\t\tconst [td1, td2] = table.addRow()\n\t\t\ttd1.text(d.label)\n\t\t\ttd2.style('text-align', 'end').text(d.value)\n\t\t}\n\t}\n\n\trenderPValueTable() {\n\t\tif (!this.settings.showPValueTable) return\n\t\t// Cap rendered rows to prevent browser OOM with large datasets (e.g. 30k+ significant promoters).\n\t\t// The full data is still available in pValueTableData.rows for export/search.\n\t\tconst maxTableRows = 5000\n\t\tconst allRows = this.viewData.pValueTableData.rows\n\t\tconst rows = allRows.length > maxTableRows ? allRows.slice(0, maxTableRows) : allRows\n\t\tif (allRows.length > maxTableRows) {\n\t\t\tthis.volcanoDom.pValueTable\n\t\t\t\t.append('div')\n\t\t\t\t.style('padding', '5px 10px')\n\t\t\t\t.style('font-size', '.8em')\n\t\t\t\t.style('color', '#666')\n\t\t\t\t.text(\n\t\t\t\t\t`Showing top ${maxTableRows.toLocaleString()} of ${allRows.length.toLocaleString()} significant results (sorted by fold-change)`\n\t\t\t\t)\n\t\t}\n\t\trenderTable({\n\t\t\tcolumns: this.viewData.pValueTableData.columns,\n\t\t\trows,\n\t\t\tdiv: this.volcanoDom.pValueTable,\n\t\t\tshowLines: true,\n\t\t\tmaxHeight: `${this.viewData.pValueTableData.height}px`,\n\t\t\tresize: true,\n\t\t\theader: { allowSort: true },\n\t\t\tnoRadioBtn: true,\n\t\t\tnoButtonCallback: (i: number) => {\n\t\t\t\t//On click, persistently highlight the data point\n\t\t\t\t// if (this.termType != GENE_EXPRESSION) return\n\t\t\t\tconst gene = this.viewData.pValueTableData.rows[i][0].value as string\n\t\t\t\tif (!gene) return\n\t\t\t\tthis.interactions.highlightDataPoint(gene)\n\t\t\t},\n\t\t\thoverEffects: (tr, row) => {\n\t\t\t\t//May restrict termTypes later\n\t\t\t\t// if (this.termType != GENE_EXPRESSION) return\n\t\t\t\t//Highlight the data point when hovering over the table row\n\t\t\t\t//Previously highlighted data points are not affected\n\t\t\t\tconst circles = this.volcanoDom.plot.selectAll('circle').nodes()\n\t\t\t\tconst dataKey = this.termType === DNA_METHYLATION ? 'promoter_id' : 'gene_name'\n\t\t\t\tconst circle = circles.find((d: any) => d.__data__[dataKey] == row[0].value) as any\n\t\t\t\tif (!circle || circle.__data__.highlighted) return\n\n\t\t\t\t/** Circles may render behind several other circles, making it hard\n\t\t\t\t * to see the highlight. Clone the circle to appear on top of the\n\t\t\t\t * elements, then destroy. */\n\t\t\t\tlet clone\n\t\t\t\ttr.on('mouseover', () => {\n\t\t\t\t\tif (circle.__data__.highlighted || clone) return\n\t\t\t\t\tclone = this.volcanoDom.plot.node()?.appendChild(circle.cloneNode(true))\n\t\t\t\t\tclone.setAttribute('fill-opacity', 0.9)\n\t\t\t\t})\n\t\t\t\ttr.on('mouseleave', () => {\n\t\t\t\t\tif (!clone) return\n\t\t\t\t\tclone.remove()\n\t\t\t\t\tclone = null\n\t\t\t\t})\n\t\t\t\t//All other circles appear dimmed on hover\n\t\t\t\tthis.volcanoDom.pValueTable.on('mouseover', () => {\n\t\t\t\t\tselectAll(circles).attr('stroke-opacity', 0.075)\n\t\t\t\t})\n\t\t\t\tthis.volcanoDom.pValueTable.on('mouseleave', () => {\n\t\t\t\t\tselectAll(circles).attr('stroke-opacity', (d: any) => (d.significant ? 0.35 : 0.2))\n\t\t\t\t})\n\t\t\t}\n\t\t})\n\t}\n\n\tsetSvgSubscriptLabel(textElem: any, prefix: string, subscript: string, suffix: string) {\n\t\ttextElem.text(null)\n\t\ttextElem.append('tspan').text(prefix)\n\t\ttextElem.append('tspan').attr('baseline-shift', 'sub').attr('font-size', '0.7em').text(subscript)\n\t\ttextElem.append('tspan').text(suffix)\n\t}\n}\n\nfunction renderDataPoints(self: any) {\n\tself.volcanoDom.plot\n\t\t.selectAll('circle')\n\t\t.data(self.viewData.pointData)\n\t\t.enter()\n\t\t.append('circle')\n\t\t.attr('stroke', (d: DataPointEntry) => rgb(d.color).formatHex())\n\t\t.attr('stroke-opacity', (d: DataPointEntry) => (d.significant ? 0.35 : 0.2))\n\t\t.attr('stroke-width', (d: DataPointEntry) => (d.significant ? 1.5 : 1))\n\t\t.attr('fill', self.settings.defaultHighlightColor)\n\t\t.attr('fill-opacity', (d: DataPointEntry) => (d.highlighted ? 0.9 : 0))\n\t\t.attr('cx', (d: DataPointEntry) => d.x)\n\t\t.attr('cy', (d: DataPointEntry) => d.y)\n\t\t.attr('r', (d: DataPointEntry) => d.radius)\n\t\t.each(function (this: any, d: DataPointEntry) {\n\t\t\tconst circle = select(this)\n\t\t\tnew DataPointMouseEvents(d, circle, self.dom.tip, self.interactions, self.termType)\n\t\t})\n}\n", "import type { ControlInputEntry } from '#mass/types/mass'\nimport type { VolcanoPlotConfig } from './VolcanoTypes'\nimport { getSampleNum } from './settings/defaults'\nimport { DNA_METHYLATION, GENE_EXPRESSION, SINGLECELL_CELLTYPE } from '#shared/terms.js'\n\n/** Handles settings the controls in the menu based on the app\n * termType.\n *\n * Add additional term type specific controls similar to\n * addGeneExpressionControlInputs(), called in\n * getVolcanoControlInputs(). Add the type to settings/Settings.ts\n *\n * If control should show for multiple but not all term types,\n * then use the getDisplayStyle arg in the control object.\n * //getDisplayStyle: () => {}\n *\n * Preferably, keep all the display (e.g. colors, sizes, etc.) controls\n * at the bottom of the list or at least together\n */\n\nexport class VolcanoControlInputs {\n\tconfig: any\n\tsampleNum?: number\n\t/** term type used to determine which controls to show */\n\ttermType: string\n\t/** control inputs for controls init */\n\tinputs: ControlInputEntry[]\n\tconstructor(config: VolcanoPlotConfig, termType: string) {\n\t\tthis.config = config\n\t\tif (this.config.termType == GENE_EXPRESSION) this.sampleNum = getSampleNum(config)\n\t\tthis.termType = termType\n\t\t//Populated with the default controls for the volcano plot\n\t\tthis.inputs = [\n\t\t\t{\n\t\t\t\tlabel: 'P value significance (-log\u2081\u2080)',\n\t\t\t\ttype: 'number',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'pValue',\n\t\t\t\ttitle: 'The p-value threshold to determine statistical significance',\n\t\t\t\tmin: 0,\n\t\t\t\t// 5e-324 is the smallest positive number greater than 0 representable\n\t\t\t\t// in IEEE 64-bit floating point (i.e. javascripts native Number.MIN_VALUE)\n\t\t\t\t// -Math.log10(5e-324) = 323.3\n\t\t\t\tmax: 323.3,\n\t\t\t\tstep: 1\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'P value',\n\t\t\t\ttype: 'radio',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'pValueType',\n\t\t\t\ttitle: 'Toggle between original and adjusted pvalues for volcano plot',\n\t\t\t\toptions: [\n\t\t\t\t\t{ label: 'Adjusted', value: 'adjusted' },\n\t\t\t\t\t{ label: 'Original', value: 'original' }\n\t\t\t\t]\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Fold change (log\u2082)',\n\t\t\t\ttype: 'number',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'foldChangeCutoff',\n\t\t\t\ttitle: 'The fold change threshold to determine biological significance',\n\t\t\t\tmin: -10,\n\t\t\t\tmax: 10\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Max interactive dots',\n\t\t\t\ttype: 'number',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'maxInteractiveDots',\n\t\t\t\ttitle:\n\t\t\t\t\t'Cap on the number of top-significant points the server returns as interactive overlay circles. The PNG still shows every dot.',\n\t\t\t\tmin: 0,\n\t\t\t\tmax: 20000,\n\t\t\t\tstep: 100\n\t\t\t},\n\t\t\t//Preferably, keep all the display (e.g. colors, sizes, etc.) controls\n\t\t\t//at the bottom of the list or at least together\n\t\t\t{\n\t\t\t\tlabel: 'Plot height',\n\t\t\t\ttype: 'number',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'height',\n\t\t\t\ttitle: 'Height of the plot in pixels',\n\t\t\t\tmin: 300,\n\t\t\t\tmax: 1000\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Plot width',\n\t\t\t\ttype: 'number',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'width',\n\t\t\t\ttitle: 'Width of the plot in pixels',\n\t\t\t\tmin: 300,\n\t\t\t\tmax: 1000\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Significant value color',\n\t\t\t\ttype: 'color',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\ttitle: 'Default color for significant data points.',\n\t\t\t\tsettingsKey: 'defaultSignColor',\n\t\t\t\tgetDisplayStyle: () => {\n\t\t\t\t\tif (this.config.termType == SINGLECELL_CELLTYPE) return 'none'\n\t\t\t\t\tconst controlColor = this.config.tw?.term?.values?.[this.config.samplelst.groups[0].name]?.color\n\t\t\t\t\tconst caseColor = this.config.tw?.term?.values?.[this.config.samplelst.groups[1].name].color\n\t\t\t\t\tif (controlColor && caseColor) return 'none'\n\t\t\t\t\telse return ''\n\t\t\t\t}\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Non-significant value color',\n\t\t\t\ttype: 'color',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\ttitle: 'Default color for non-significant data points.',\n\t\t\t\tsettingsKey: 'defaultNonSignColor'\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Highlight color',\n\t\t\t\ttype: 'color',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\ttitle: 'Default color for highlighted data points.',\n\t\t\t\tsettingsKey: 'defaultHighlightColor'\n\t\t\t}\n\t\t]\n\n\t\tthis.setVolcanoControlInputs()\n\t}\n\n\t/** Add more term type specific controls here. */\n\tsetVolcanoControlInputs() {\n\t\tthis.addGeneExpControlInputs()\n\t\tthis.addDNAMethControlInputs()\n\t\tthis.addSingleCellCTControlInputs()\n\t}\n\n\taddGeneExpControlInputs() {\n\t\tif (this.termType !== GENE_EXPRESSION) return\n\t\tconst geInputs = [\n\t\t\t{\n\t\t\t\tlabel: 'Minimum read count',\n\t\t\t\ttype: 'number',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'minCount',\n\t\t\t\ttitle: 'The smallest number of reads required for a gene to be considered in the analysis',\n\t\t\t\tmin: 0,\n\t\t\t\tmax: 10000\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Minimum total read count',\n\t\t\t\ttype: 'number',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'minTotalCount',\n\t\t\t\ttitle: 'The smallest total number of reads required for a gene to be considered in the analysis',\n\t\t\t\tmin: 0,\n\t\t\t\tmax: 10000\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'CPM cutoff',\n\t\t\t\ttype: 'number',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'cpmCutoff',\n\t\t\t\ttitle: 'The minimum normalized expression threshold to retain only genes with sufficient expression',\n\t\t\t\tmin: 0\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Method',\n\t\t\t\ttype: 'radio',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'method',\n\t\t\t\ttitle: 'Toggle between analysis methods',\n\t\t\t\toptions: this.getMethodOptions()\n\t\t\t}\n\t\t\t// {\n\t\t\t// \tlabel: 'Rank Genes by',\n\t\t\t// \ttype: 'radio',\n\t\t\t// \tchartType: 'volcano',\n\t\t\t// \tsettingsKey: 'rankBy',\n\t\t\t// \ttitle: 'Rank genes by either the absolute value of the fold change or the variance',\n\t\t\t// \toptions: [\n\t\t\t// \t\t{ label: 'abs(Fold Change)', value: 'abs(foldChange)' },\n\t\t\t// \t\t{ label: 'Variance', value: 'variance' }\n\t\t\t// \t],\n\t\t\t// \t//TODO: will enable this feature when there is backhand support\n\t\t\t// \tgetDisplayStyle: () => 'none'\n\t\t\t// }\n\t\t]\n\n\t\tthis.inputs.splice(0, 0, ...geInputs)\n\t}\n\n\taddDNAMethControlInputs() {\n\t\tif (this.termType !== DNA_METHYLATION) return\n\t\tconst dmInputs = [\n\t\t\t{\n\t\t\t\tlabel: 'Min samples per group',\n\t\t\t\ttype: 'number',\n\t\t\t\tchartType: 'volcano',\n\t\t\t\tsettingsKey: 'minSamplesPerGroup',\n\t\t\t\ttitle: 'Minimum non-NA samples required per group for a promoter to be tested',\n\t\t\t\tmin: 1,\n\t\t\t\tmax: 100\n\t\t\t}\n\t\t]\n\t\tthis.inputs.splice(0, 0, ...dmInputs)\n\t}\n\n\taddSingleCellCTControlInputs() {\n\t\tif (this.termType !== SINGLECELL_CELLTYPE) return\n\n\t\tconst scctInputs = []\n\n\t\tthis.inputs.splice(0, 0, ...scctInputs)\n\t}\n\n\tgetMethodOptions() {\n\t\tif (this.termType !== GENE_EXPRESSION) return\n\t\tconst settings = this.config.settings.volcano\n\t\tconst features = JSON.parse(sessionStorage.getItem('optionalFeatures') as string)\n\t\tif (features?.runDE_methods?.length) {\n\t\t\tconst opts: { label: string; value: string }[] = []\n\t\t\tfor (const m of features.runDE_methods) {\n\t\t\t\topts.push({ label: m, value: m.toLowerCase() })\n\t\t\t}\n\t\t\treturn opts\n\t\t}\n\t\tif (this.sampleNum! < settings!.sampleNumCutoff) {\n\t\t\treturn [\n\t\t\t\t{ label: 'edgeR', value: 'edgeR' },\n\t\t\t\t{ label: 'Wilcoxon', value: 'wilcoxon' },\n\t\t\t\t{ label: 'Limma', value: 'limma' }\n\t\t\t]\n\t\t} else return [{ label: 'Wilcoxon', value: 'wilcoxon' }]\n\t}\n}\n", "import type { MassState, BasePlotConfig } from '#mass/types/mass'\nimport { getCompInit, copyMerge, type RxComponent, type AppApi } from '#rx'\nimport { PlotBase } from '../PlotBase'\nimport { fillTermWrapper } from '#termsetting'\nimport { Menu, sayerror } from '#dom'\nimport { controlsInit } from '../controls'\nimport { getDefaultVolcanoSettings, validateVolcanoSettings } from './settings/defaults'\nimport type { VolcanoOpts, VolcanoDom } from './VolcanoTypes'\nimport { VolcanoModel } from './model/VolcanoModel'\nimport { VolcanoViewModel } from './viewModel/VolcanoViewModel'\nimport { VolcanoInteractions } from './interactions/VolcanoInteractions'\nimport { VolcanoPlotView } from './view/VolcanoPlotView'\nimport { VolcanoControlInputs } from './VolcanoControlInputs'\nimport { getCombinedTermFilter } from '#filter'\nimport { GENE_EXPRESSION, SINGLECELL_CELLTYPE } from '#shared/terms.js'\n\nclass Volcano extends PlotBase implements RxComponent {\n\tstatic type = 'volcano'\n\ttype: string\n\tcomponents: { controls: any }\n\tdom: VolcanoDom\n\tinteractions?: VolcanoInteractions\n\tmodel!: VolcanoModel\n\tview!: VolcanoPlotView\n\ttermType: string\n\n\tconstructor(opts: VolcanoOpts, api) {\n\t\tsuper(opts, api)\n\t\tif (this.opts.parentId) this.parentId = this.opts.parentId\n\t\tthis.type = Volcano.type\n\t\tthis.components = {\n\t\t\tcontrols: {}\n\t\t}\n\n\t\tthis.termType = opts.termType\n\t\tconst holder = opts.holder\n\t\t\t.classed('sjpp-volcano-main', true)\n\t\t\t.attr('data-testid', `sjpp-volcano-main-${opts.termType}`)\n\t\t//Either allow a node to be passed or create a new div\n\t\tconst controls = typeof opts.controls == 'object' ? opts.controls : holder || (holder as any).append('div')\n\t\tconst error = opts.holder\n\t\t\t.append('div')\n\t\t\t.attr('id', 'sjpp-volcano-error')\n\t\t\t.attr('data-testid', `sjpp-volcano-error-${opts.termType}`)\n\t\t\t.style('opacity', 0.75) as any\n\t\tthis.dom = {\n\t\t\tholder,\n\t\t\tcontrols,\n\t\t\terror,\n\t\t\twait: holder\n\t\t\t\t.append('div')\n\t\t\t\t.attr('id', 'sjpp-volcano-wait')\n\t\t\t\t.attr('data-testid', `sjpp-volcano-wait-${opts.termType}`)\n\t\t\t\t.style('opacity', 0.75)\n\t\t\t\t.style('padding', '20px')\n\t\t\t\t.text('Loading...') as any,\n\t\t\ttip: new Menu({ padding: '' }),\n\t\t\tactionsTip: new Menu({ padding: '' })\n\t\t}\n\t}\n\n\tgetState(appState: MassState) {\n\t\tconst config: any = appState.plots.find((p: BasePlotConfig) => p.id === this.id)\n\t\tif (!config) {\n\t\t\tthrow new Error(\n\t\t\t\t`No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`\n\t\t\t)\n\t\t}\n\t\tconst parentConfig: any = this.parentId && appState.plots.find(p => p.id === this.parentId)\n\t\tconst termfilter = getCombinedTermFilter(appState, config.filter || parentConfig?.filter)\n\n\t\treturn {\n\t\t\tconfig: Object.assign({}, config, {\n\t\t\t\tsettings: {\n\t\t\t\t\tvolcano: config.settings.volcano\n\t\t\t\t}\n\t\t\t}),\n\t\t\ttermfilter\n\t\t}\n\t}\n\n\tasync setControls() {\n\t\tconst plotConfig = this.app.getState().plots.find((p: any) => p.id === this.id)\n\t\tconst controls = new VolcanoControlInputs(plotConfig, this.termType)\n\n\t\tthis.components.controls = await controlsInit({\n\t\t\tapp: this.app,\n\t\t\tid: this.id,\n\t\t\tholder: this.dom.controls.style('display', 'inline-block'),\n\t\t\tinputs: controls.inputs\n\t\t})\n\n\t\tthis.components.controls.on('downloadClick.volcano', () => this.interactions!.download(this.termType))\n\t\tif (plotConfig.chartType == 'differentialAnalysis')\n\t\t\tthis.components.controls.on('helpClick.differentialAnalysis', () =>\n\t\t\t\t//Opens the page for the differential analysis wiki\n\t\t\t\t//Can't put in parent as DA does not have a controls component\n\t\t\t\twindow.open('https://github.com/stjude/proteinpaint/wiki/Differential-analysis')\n\t\t\t)\n\t}\n\n\tasync init() {\n\t\tthis.interactions = new VolcanoInteractions(this.app, this.id, this.dom)\n\t\tthis.model = new VolcanoModel(this.app, this.termType)\n\t\tthis.view = new VolcanoPlotView(this.dom, this.interactions, this.termType)\n\t\tawait this.setControls()\n\t}\n\n\tasync main() {\n\t\tif (!this.interactions) throw new Error('Volcano Interactions not initialized')\n\t\tif (!this.model) throw new Error('Volcano Model not initialized')\n\t\tif (!this.view) throw new Error('Volcano View not initialized')\n\n\t\tconst config = structuredClone(this.state.config)\n\t\t//TODO: Fix this to use parentId instead\n\t\tif (config.chartType != this.type && config.childType != this.type) return\n\n\t\tconst settings = config.settings.volcano\n\t\ttry {\n\t\t\t//Only show Loading for data requests that take longer than 500ms\n\t\t\tconst showWait = setTimeout(() => {\n\t\t\t\tthis.dom.wait.style('display', 'block')\n\t\t\t}, 500)\n\n\t\t\t/** Fetch data */\n\t\t\tconst response = await this.model.getData(config, settings)\n\t\t\tthis.dom.error.text('')\n\t\t\tif (!response || response.error || !response.data || !response.data.volcanoPng || !response.data.totalRows) {\n\t\t\t\tsayerror(this.dom.error, response?.error || 'No data returned from server')\n\t\t\t\tclearTimeout(showWait)\n\t\t\t\tthis.dom.wait.style('display', 'none')\n\t\t\t\treturn\n\t\t\t}\n\n\t\t\t/** Format response into an object for rendering */\n\t\t\tconst viewModel = new VolcanoViewModel(config, response, settings)\n\t\t\t//Pass table data for downloading\n\t\t\tthis.interactions.pValueTableData = viewModel.viewData.pValueTableData\n\t\t\tthis.interactions.data = response.data.dots\n\n\t\t\t/** Render formatted data */\n\t\t\tthis.view.render(settings, viewModel.viewData)\n\n\t\t\tif (!response.data.dots.length) {\n\t\t\t\tthis.dom.error.text('No points passed the significance thresholds').style('color', '#555')\n\t\t\t}\n\n\t\t\tclearTimeout(showWait)\n\t\t\tthis.dom.wait.style('display', 'none')\n\t\t} catch (e: any) {\n\t\t\tif (e instanceof Error) console.error(e.message || e)\n\t\t\telse if (e.stack) console.log(e.stack)\n\t\t\tthrow e\n\t\t}\n\t}\n}\n\nexport const volcanoInit = getCompInit(Volcano)\nexport const componentInit = volcanoInit\n\nexport async function getPlotConfig(opts: any, app: AppApi) {\n\tif (!opts.termType) throw new Error('.termType is required')\n\n\tconst config = {\n\t\tsettings: {\n\t\t\tvolcano: getDefaultVolcanoSettings(opts.overrides, opts)\n\t\t},\n\t\thighlightedData: opts.highlightedData || [],\n\t\ttermType: opts.termType\n\t}\n\n\t//Define Gene Expression config\n\tif (opts.termType == GENE_EXPRESSION) {\n\t\tif (opts.confounderTws) {\n\t\t\ttry {\n\t\t\t\tfor (const tw of opts.confounderTws) {\n\t\t\t\t\tawait fillTermWrapper(tw, app.vocabApi)\n\t\t\t\t}\n\t\t\t} catch (e: any) {\n\t\t\t\tconsole.error(e.message || e)\n\t\t\t\tthrow new Error(`Volcano getPlotConfig() failed to fill confounder term wrappers: ${e}`)\n\t\t\t}\n\t\t}\n\t\tObject.assign(config, {\n\t\t\tconfounderTws: opts.confounderTws || [],\n\t\t\tsamplelst: opts.samplelst\n\t\t})\n\t}\n\n\t//Define Single Cell Cell Type config\n\tif (opts.termType == SINGLECELL_CELLTYPE) {\n\t\tObject.assign(config, {\n\t\t\t//TODO: Fix this logic\n\t\t\tsample: opts.experimentID || opts.sample || opts.samples?.[0]?.experiments[0]?.experimentID,\n\t\t\ttermId: app.vocabApi.termdbConfig.queries.singleCell.DEgenes.termId,\n\t\t\t//TODO: 'Cluster' is a fallback for development\n\t\t\t//Should require opts.categoryName in the future\n\t\t\tcategoryName: opts.categoryName || 'Cluster'\n\t\t})\n\t}\n\n\t//Validate user submitted unavailable/inappropriate settings\n\tvalidateVolcanoSettings(config, opts)\n\n\treturn copyMerge(config, opts)\n}\n"],
+  "mappings": ";;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;AAeO,IAAM,mBAAN,MAAuB;AAAA,EA2B7B,YAAY,QAA2B,UAA0B,UAAoC;AAnBrG,0BAAiB;AACjB,6BAAoB;AACpB,4BAAmB;AACnB,4BAAmB;AAEnB;AAAA,wBAAe;AACf,wBAAe;AAEf;AAAA,4BAAmB;AAGnB,SAAS,SAAS;AAClB,SAAS,YAAY;AACrB,SAAS,WAAW;AACpB,SAAS,SAAS;AAMjB,SAAK,SAAS;AACd,SAAK,WAAW;AAChB,SAAK,QAAQ,KAAK,WAAW,KAAK,SAAS;AAE3C,SAAK,WAAW,SAAS,KAAK;AAI9B,UAAM,EAAE,WAAW,aAAa,IAAI,eAAe,KAAK,MAAM;AAC9D,UAAM,UAAU,EAAE,eAAe,cAAc,eAAe,UAAU;AAExE,SAAK,cAAc;AAAA,MAClB,SAAS;AAAA,QACR,EAAE,OAAO,0BAAqB,SAAS,UAAU,KAAK;AAAA,QACtD,EAAE,OAAO,oBAAoB,UAAU,KAAK;AAAA,QAC5C,EAAE,OAAO,oBAAoB,UAAU,KAAK;AAAA,MAC7C;AAAA;AAAA;AAAA,MAGA,MAAM,CAAC;AAAA,MACP,QAAQ,SAAS,SAAS,KAAK;AAAA,IAChC;AACA,SAAK,WAAW;AAChB,SAAK,WAAW,OAAO;AACvB,SAAK,WAAW,KAAK,YAAY;AAEjC,SAAK,gBAAgB;AAErB,UAAM,UAAU,KAAK,kBAAkB;AACvC,SAAK,iBAAiB;AACtB,UAAM,YAAY,KAAK,aAAa,SAAS,cAAc,SAAS;AAEpE,QAAI,KAAK,SAAS,iBAAiB;AAElC,YAAM,gBAAgB,KAAK,YAAY,QAAQ,UAAU,OAAK,EAAE,MAAM,SAAS,wBAAmB,CAAC;AACnG,WAAK,YAAY,KAAK,KAAK,CAAC,GAAQ,MAAW,EAAE,aAAa,EAAE,QAAQ,EAAE,aAAa,EAAE,KAAK;AAAA,IAC/F;AAEA,SAAK,WAAW;AAAA,MACf,QAAQ,SAAS,UAAU,CAAC;AAAA,MAC5B,UAAU,KAAK,YAAY,OAAO;AAAA,MAClC;AAAA,MACA;AAAA,MACA,iBAAiB,KAAK;AAAA,MACtB,WAAW,KAAK,aAAa;AAAA,MAC7B,aAAa,KAAK,eAAe;AAAA,MACjC,YAAY,SAAS,KAAK;AAAA,MAC1B,YAAY,SAAS,KAAK;AAAA,IAC3B;AAAA,EACD;AAAA,EAEA,cAAc;AACb,QAAI,KAAK,YAAY,gBAAiB,QAAO;AAAA,aACpC,KAAK,YAAY,gBAAiB,QAAO;AAAA,aACzC,KAAK,YAAY,oBAAqB,QAAO;AAAA,QACjD,OAAM,IAAI,MAAM,qBAAqB,KAAK,QAAQ,EAAE;AAAA,EAC1D;AAAA,EAEA,kBAAkB;AAKjB,UAAM,MAAM,KAAK,SAAS,KAAK;AAC/B,SAAK,mBAAmB,IAAI;AAC5B,SAAK,mBAAmB,IAAI;AAC5B,SAAK,eAAe,IAAI;AACxB,SAAK,eAAe,IAAI;AACxB,QAAI,IAAI,mBAAmB,EAAG,MAAK,mBAAmB,IAAI;AAAA,EAC3D;AAAA,EAEA,oBAAoB;AACnB,UAAM,SAAS,OAAY,EAAE,OAAO,CAAC,KAAK,kBAAkB,KAAK,gBAAgB,CAAC,EAAE,MAAM,CAAC,GAAG,KAAK,SAAS,KAAK,CAAC;AAClH,UAAM,SAAS,OAAY,EAAE,OAAO,CAAC,KAAK,cAAc,KAAK,YAAY,CAAC,EAAE,MAAM,CAAC,KAAK,SAAS,QAAQ,CAAC,CAAC;AAE3G,WAAO;AAAA,MACN,KAAK;AAAA;AAAA,QAEJ,QAAQ,KAAK,SAAS,SAAS,KAAK,SAAS,KAAK,YAAY,IAAI,KAAK,SAAS;AAAA,QAChF,OAAO,KAAK,SAAS,QAAQ,KAAK,WAAW;AAAA,MAC9C;AAAA,MACA,KAAK;AAAA,QACJ,GAAG,KAAK;AAAA,QACR,GAAG;AAAA,MACJ;AAAA,MACA,YAAY;AAAA,QACX,GAAG,KAAK,WAAW,KAAK,SAAS,QAAQ,IAAI,KAAK;AAAA,QAClD,GAAG,KAAK,SAAS,KAAK,SAAS,SAAS,KAAK,YAAY,KAAK;AAAA,MAC/D;AAAA,MACA,QAAQ;AAAA,QACP,OAAO;AAAA,QACP,GAAG,KAAK;AAAA,QACR,GAAG,KAAK,SAAS,SAAS,KAAK,SAAS,KAAK,SAAS;AAAA,MACvD;AAAA,MACA,YAAY;AAAA,QACX,MAAM,UAAU,KAAK,SAAS,UAAU;AAAA,QACxC,GAAG,KAAK,WAAW;AAAA,QACnB,GAAG,KAAK,SAAS,KAAK,SAAS,SAAS;AAAA,MACzC;AAAA,MACA,QAAQ;AAAA,QACP,OAAO;AAAA,QACP,GAAG,KAAK;AAAA,QACR,GAAG,KAAK;AAAA,MACT;AAAA,MACA,MAAM;AAAA,QACL,QAAQ,KAAK,SAAS;AAAA,QACtB,OAAO,KAAK,SAAS;AAAA,QACrB,GAAG,KAAK;AAAA,QACR,GAAG,KAAK;AAAA,MACT;AAAA,MACA,mBAAmB;AAAA,QAClB,GAAG,OAAO,CAAC,IAAI,KAAK;AAAA,QACpB,IAAI,KAAK;AAAA,QACT,IAAI,KAAK,SAAS,SAAS,KAAK,SAAS;AAAA,MAC1C;AAAA,IACD;AAAA,EACD;AAAA,EAEA,YACC,SAGC;AACD,QAAI,KAAK,YAAY,mBAAmB,KAAK,YAAY,gBAAiB;AAC1E,UAAM,WAAW,CAAC,SAAiB;AAClC,UAAI,KAAK,UAAU,GAAI,QAAO,KAAK,UAAU,GAAG,EAAE,IAAI;AACtD,aAAO;AAAA,IACR;AAEA,WAAO;AAAA;AAAA,MAEN,GAAG,QAAQ,IAAI,IAAI;AAAA,MACnB,OAAO;AAAA;AAAA,QAEN,OAAO,SAAS,GAAG,KAAK,OAAO,UAAU,OAAO,CAAC,EAAE,IAAI,KAAK,KAAK,SAAS,YAAY,GAAG;AAAA,QACzF,GAAG;AAAA;AAAA,MAEJ;AAAA,MACA,QAAQ;AAAA;AAAA,QAEP,OAAO,SAAS,GAAG,KAAK,OAAO,UAAU,OAAO,CAAC,EAAE,IAAI,KAAK,KAAK,SAAS,YAAY,GAAG;AAAA,QACzF,GAAG,KAAK,SAAS;AAAA;AAAA,MAElB;AAAA,IACD;AAAA,EACD;AAAA,EAEA,aAAa,SAAgC,cAAsB,WAAmB;AACrF,UAAM,SAAS,KAAK,IAAI,KAAK,SAAS,OAAO,KAAK,SAAS,MAAM,IAAI;AACrE,UAAM,WAAgB,gBAAgB,KAAK,QAAQ;AACnD,eAAW,KAAK,UAAU;AACzB,YAAM,eAAe,KAAK,aAAa,kBAAkB,EAAE,cAAc,EAAE;AAC3E,QAAE,cAAc,KAAK,QAAQ,iBAAiB,SAAS,YAAY;AAEnE,QAAE,cAAc;AAChB,WAAK,cAAc,GAAG,EAAE,aAAa,cAAc,SAAS;AAC5D,UAAI,EAAE,aAAa;AAClB,aAAK;AACL,cAAM,MAAM;AAAA,UACX,EAAE,OAAO,eAAe,EAAE,WAAW,EAAE;AAAA,UACvC,EAAE,OAAO,eAAe,EAAE,gBAAgB,EAAE;AAAA,UAC5C,EAAE,OAAO,eAAe,EAAE,gBAAgB,EAAE;AAAA,QAC7C;AACA,YAAI,KAAK,YAAY,iBAAiB;AACrC,cAAI,OAAO,GAAG,GAAG,EAAE,OAAO,EAAE,eAAe,GAAG,GAAG,EAAE,OAAO,EAAE,aAAa,GAAG,CAAC;AAAA,QAC9E,OAAO;AACN,cAAI,OAAO,GAAG,GAAG,EAAE,OAAO,EAAE,aAAa,GAAG,CAAC;AAAA,QAC9C;AAEA,YAAI,KAAK,SAAS,gBAAiB,MAAK,YAAY,KAAK,KAAK,GAAG;AAAA,MAClE,OAAO;AACN,aAAK;AAAA,MACN;AACA,QAAE,IAAI,QAAQ,OAAO,MAAM,EAAE,WAAW,IAAI,KAAK;AACjD,YAAM,IACL,EAAE,GAAG,KAAK,SAAS,UAAU,UAAU,KAAK,IAAI,KAAK,mBAAmB,EAAE,GAAG,KAAK,SAAS,UAAU,UAAU;AAChH,QAAE,IAAI,QAAQ,OAAO,MAAM,CAAC,KAAK,MAAM,CAAC,CAAC,IAAI,KAAK;AAClD,QAAE,SAAS;AAAA,IACZ;AAGA,SAAK,iBAAiB,KAAK,SAAS,KAAK;AACzC,SAAK,oBAAoB,KAAK,IAAI,GAAG,KAAK,SAAS,KAAK,YAAY,KAAK,cAAc;AAEvF,aAAS,KAAK,CAAC,GAAQ,MAAW,EAAE,cAAc,EAAE,WAAW;AAC/D,WAAO;AAAA,EACR;AAAA,EAEA,cAAc,GAAmB,aAAsB,cAAsB,WAAmB;AAC/F,QAAI,CAAC,EAAE,aAAa,KAAK,YAAY;AACpC,YAAM,IAAI,MAAM,8BAA8B,KAAK,UAAU,CAAC,CAAC,EAAE;AAClE,QAAI,aAAa;AAChB,UAAI,gBAAgB,UAAW,GAAE,QAAQ,EAAE,cAAc,IAAI,YAAY;AAAA,UACpE,GAAE,QAAQ,KAAK,SAAS;AAAA,IAC9B,MAAO,GAAE,QAAQ,KAAK,SAAS;AAAA,EAChC;AAAA,EAEA,eAAe;AACd,UAAM,YAAY;AAAA,MACjB;AAAA,QACC,OAAO,6BAA6B,KAAK,QAAQ;AAAA,QACjD,OAAO,eAAgB,KAAK,iBAAiB,OAAQ,KAAK,iBAAiB,KAAK,kBAAkB;AAAA,MACnG;AAAA,MACA;AAAA,QACC,OAAO,yBAAyB,KAAK,QAAQ;AAAA,QAC7C,OAAO,KAAK;AAAA,MACb;AAAA,MACA;AAAA,QACC,OAAO,mBAAmB,KAAK,QAAQ;AAAA,QACvC,OAAO,KAAK,iBAAiB,KAAK;AAAA,MACnC;AAAA,IACD;AACA,QAAI,KAAK,YAAY,mBAAmB,KAAK,YAAY,iBAAiB;AACzE,gBAAU;AAAA,QACT;AAAA,UACC,OAAO,KAAK,OAAO,UAAU,OAAO,CAAC,EAAE,OAAO;AAAA,UAC9C,OAAO,KAAK,SAAS;AAAA,QACtB;AAAA,QACA;AAAA,UACC,OAAO,KAAK,OAAO,UAAU,OAAO,CAAC,EAAE,OAAO;AAAA,UAC9C,OAAO,KAAK,SAAS;AAAA,QACtB;AAAA,MACD;AAAA,IACD;AAEA,QAAI,KAAK,SAAS,QAAQ,UAAa,KAAK,SAAS,QAAQ,MAAM;AAClE,gBAAU,KAAK;AAAA,QACd,OAAO;AAAA,QACP,OAAO,eAAe,KAAK,SAAS,GAAG;AAAA,MACxC,CAAC;AAAA,IACF;AACA,WAAO;AAAA,EACR;AAAA,EAEA,mBAAmB;AAClB,QAAI,KAAK,YAAY,iBAAiB;AACrC,WAAK,YAAY,QAAQ,OAAO,GAAG,GAAG,EAAE,OAAO,YAAY,UAAU,KAAK,GAAG,EAAE,OAAO,WAAW,UAAU,KAAK,CAAC;AAAA,IAClH,OAAO;AACN,WAAK,YAAY,QAAQ,OAAO,GAAG,GAAG,EAAE,OAAO,aAAa,UAAU,KAAK,CAAC;AAAA,IAC7E;AAAA,EACD;AAAA,EAEA,iBAAiB;AAChB,UAAM,cAAc;AAAA,MACnB,QAAQ,oBAAI,IAAY;AAAA,IACzB;AACA,QAAI,KAAK,YAAY,iBAAiB;AACrC,UAAI,KAAK,SAAS,UAAU,WAAW,aAAa,KAAK,MAAM,IAAI,KAAK;AACvE,oBAAY,OAAO,IAAI,qBAAqB;AAAA,MAC7C;AACA,UAAI,KAAK,SAAS,UAAU,WAAY,aAAY,OAAO,IAAI,qBAAqB;AAAA,IACrF;AACA,WAAO;AAAA,EACR;AACD;;;AClSO,IAAM,sBAAN,MAA0B;AAAA,EAOhC,YAAY,KAAiB,IAAY,KAAiB;AACzD,SAAK,MAAM;AACX,SAAK,MAAM;AACX,SAAK,KAAK;AACV,SAAK,kBAAkB,CAAC;AACxB,SAAK,OAAO,CAAC;AAAA,EACd;AAAA;AAAA;AAAA,EAIA,MAAM,kBAAkB;AACvB,UAAM,QAAQ,KAAK,IAAI,SAAS;AAChC,UAAM,SAAS,MAAM,MAAM,KAAK,CAAC,MAAyB,EAAE,OAAO,KAAK,EAAE;AAC1E,QAAI,OAAO,aAAa,mBAAmB,OAAO,aAAa,gBAAiB;AAKhF,UAAM,oBAAoB,oBAAI,IAAI,CAAC,OAAO,UAAU,OAAO,CAAC,EAAE,MAAM,OAAO,UAAU,OAAO,CAAC,EAAE,IAAI,CAAC;AACpG,UAAM,WAAwB,IAAI;AAAA,OAChC,KAAK,KAAK,UAAU,MAAM,UAAU,CAAC,GACpC,OAAO,OAAK,kBAAkB,IAAI,EAAE,IAAI,CAAC,EACzC;AAAA,QAAQ,OACR,EAAE,OAAO,IAAI,QAAQ,OAAK;AACzB,cAAI,EAAE,KAAK,KAAM,QAAO,EAAE,IAAI;AAAA,cACzB,QAAO,EAAE,IAAI,IAAI,OAAK,EAAE,IAAI,IAAI;AAAA,QACtC,CAAC;AAAA,MACF;AAAA,IACF;AACA,UAAM,gBAAuB,SAAS,OAAO,MAAM,KAAK,QAAQ,IAAI,CAAC;AACrE,UAAM,SAAS,OAAO,SAAS,QAAQ,UAAU,UAAU,IAAI;AAE/D,UAAM,KAAK,IAAI,uBAAuB;AAAA,MACrC,KAAK,KAAK;AAAA,MACV,UAAU,OAAO,QAAa;AAC7B,aAAK,IAAI,WAAW,KAAK;AACzB,cAAM,KAAK,IAAI,SAAS;AAAA,UACvB,MAAM;AAAA,UACN,IAAI,KAAK;AAAA,UACT,QAAQ,EAAE,eAAe,IAAI;AAAA,QAC9B,CAAC;AAAA,MACF;AAAA,MACA,QAAQ,KAAK,IAAI,WAAW;AAAA,MAC5B,YAAY;AAAA,MACZ;AAAA,MACA;AAAA,MACA,QAAQ,OAAO;AAAA,MACf;AAAA,IACD,CAAC;AACD,UAAM,GAAG,SAAS;AAAA,EACnB;AAAA,EAEA,SAAS,UAAkB;AAC1B,SAAK,IAAI,WAAW,MAAM,EAAE,UAAU,KAAK,IAAI,SAAS,OAAO,KAAK,EAAE,KAAK,CAAC;AAC5E,UAAM,OAAO;AAAA,MACZ;AAAA,QACC,MAAM;AAAA,QACN,UAAU,MAAM;AACf,gBAAM,MAAM,KAAK,IAAI,OAAO,OAAO,KAAK,EAAE,KAAK;AAC/C,iBAAO,KAAK,gBAAgB,QAAQ,qBAAqB,EAAE,kBAAkB,KAAK,CAAC;AAAA,QACpF;AAAA,MACD;AAAA,MACA;AAAA,QACC,MAAM;AAAA,QACN,UAAU,MAAM;AACf,wBAAc,KAAK,gBAAgB,MAAM,KAAK,gBAAgB,OAAO;AAAA,QACtE;AAAA,MACD;AAAA,IACD;AACA,eAAW,OAAO,MAAM;AACvB,WAAK,IAAI,WAAW,EAAE,OAAO,KAAK,EAAE,KAAK,SAAS,gBAAgB,EAAE,KAAK,IAAI,IAAI,EAAE,GAAG,SAAS,IAAI,QAAQ;AAAA,IAC5G;AAAA,EACD;AAAA,EAEA,MAAM,mBAAmB,OAAe;AACvC,UAAM,SAAS,KAAK,IAAI,SAAS,EAAE,MAAM,KAAK,CAAC,MAAyB,EAAE,OAAO,KAAK,EAAE;AACxF,UAAM,kBAAkB,OAAO,gBAAgB,SAAS,KAAK,IAC1D,OAAO,gBAAgB,OAAO,OAAK,MAAM,KAAK,IAC9C,CAAC,GAAG,OAAO,iBAAiB,KAAK;AACpC,UAAM,KAAK,IAAI,SAAS;AAAA,MACvB,MAAM;AAAA,MACN,IAAI,KAAK;AAAA,MACT,QAAQ,EAAE,gBAAgB;AAAA,IAC3B,CAAC;AAAA,EACF;AAAA;AAAA;AAAA,EAIA,cAAc,OAAe;AAC5B,UAAM,SAAS,KAAK,IAAI,SAAS,EAAE,MAAM,KAAK,CAAC,MAAyB,EAAE,OAAO,KAAK,EAAE;AACxF,UAAM,SAAS,CAAC;AAChB,eAAW,SAAS,OAAO,UAAU,QAAQ;AAC5C,aAAO,MAAM,IAAI,IAAI;AAAA,QACpB,KAAK,MAAM;AAAA,QACX,OAAO,MAAM;AAAA,QACb,MAAM,MAAM;AAAA,MACb;AAAA,IACD;AAIA,UAAM,UAAU,MAAM;AACrB,UAAI,OAAO,YAAY,iBAAiB;AACvC,eAAO;AAAA,UACN,GAAG,EAAE,MAAM,aAAa;AAAA,UACxB,MAAM;AAAA,YACL,MAAM;AAAA,YACN,MAAM;AAAA,YACN,MAAM,OAAO;AAAA,UACd;AAAA,QACD;AAAA,MACD,MAAO,QAAO,OAAO;AAAA,IACtB;AACA,SAAK,IAAI,SAAS;AAAA,MACjB,MAAM;AAAA,MACN,QAAQ;AAAA,QACP,WAAW;AAAA,QACX,WAAW;AAAA,QACX,MAAM,QAAQ;AAAA,QACd,OAAO;AAAA,UACN,GAAG,EAAE,QAAQ,OAAO,GAAG,EAAE,QAAQ,MAAM,mBAAmB;AAAA,UAC1D,MAAM,OAAO,GAAG;AAAA,QACjB;AAAA,MACD;AAAA,IACD,CAAC;AAAA,EACF;AAAA;AAAA,EAGA,oBAAoB,OAAe;AAClC,UAAM,SAAS,KAAK,IAAI,SAAS,EAAE,MAAM,KAAK,CAAC,MAAyB,EAAE,OAAO,KAAK,EAAE;AACxF,SAAK,IAAI,SAAS;AAAA,MACjB,MAAM;AAAA,MACN,QAAQ;AAAA,QACP,WAAW;AAAA,QACX,WAAW;AAAA,QACX,MAAM;AAAA,UACL,GAAG,EAAE,MAAM,aAAa;AAAA,UACxB,MAAM;AAAA,YACL,MAAM;AAAA,YACN,MAAM;AAAA,YACN,MAAM,OAAO;AAAA,UACd;AAAA,QACD;AAAA,QACA,OAAO;AAAA,UACN,GAAG,EAAE,QAAQ,OAAO,GAAG,EAAE,QAAQ,MAAM,mBAAmB;AAAA,UAC1D,MAAM,OAAO,GAAG;AAAA,QACjB;AAAA,MACD;AAAA,IACD,CAAC;AAAA,EACF;AAAA,EAEA,oBAAoB;AACnB,UAAM,aAAa,KAAK,IAAI,SAAS,EAAE,MAAM,KAAK,CAAC,MAAyB,EAAE,OAAO,KAAK,EAAE;AAC5F,UAAM,SAAS,KAAK,IAAI,WAAW,EAAE,OAAO,KAAK,EAAE,MAAM,WAAW,KAAK;AACzE,UAAM,mBACL,WAAW,aAAa,kBAAkB,KAAK,KAAK,IAAI,OAAK,EAAE,WAAW,IAAI,KAAK,KAAK,IAAI,OAAK,EAAE,SAAS;AAC7G,QAAI,cAAc;AAAA,MACjB;AAAA,MACA,QAAQ,KAAK,IAAI,KAAK;AAAA,MACtB,UAAU,KAAK,IAAI;AAAA,MACnB;AAAA,MACA,UAAU,WAAW,gBAAgB,IAAI,OAAK;AAC7C,eAAO,EAAE,MAAM,EAAE;AAAA,MAClB,CAAC;AAAA,MACD,cAAc;AAAA,QACb;AAAA,UACC,OAAO;AAAA,UACP,iBAAiB,MAAO,WAAW,gBAAgB,SAAS,IAAI,KAAK;AAAA,UACrE,WAAW,YAAY;AACtB,kBAAM,KAAK,IAAI,SAAS;AAAA,cACvB,MAAM;AAAA,cACN,IAAI,KAAK;AAAA,cACT,QAAQ,EAAE,iBAAiB,CAAC,EAAE;AAAA,YAC/B,CAAC;AACD,iBAAK,IAAI,WAAW,KAAK;AAAA,UAC1B;AAAA,QACD;AAAA,MACD;AAAA,MACA,UAAU,OAAM,WAAU;AACzB,cAAM,kBAAkB,OAAO,SAAS,IAAI,OAAK,EAAE,IAAI;AACvD,cAAM,KAAK,IAAI,SAAS;AAAA,UACvB,MAAM;AAAA,UACN,IAAI,KAAK;AAAA,UACT,QAAQ,EAAE,gBAAgB;AAAA,QAC3B,CAAC;AACD,aAAK,IAAI,WAAW,KAAK;AAAA,MAC1B;AAAA,IACD,CAAC;AAAA,EACF;AAAA;AAAA;AAAA;AAAA,EAKA,MAAM,UAAU,GAAsE;AACrF,UAAM,SAAS,KAAK,IAAI,SAAS,EAAE,MAAM,KAAK,CAAC,MAAyB,EAAE,OAAO,KAAK,EAAE;AAExF,UAAM,eAAe,QAAQ,IAAI,MAAM,SAAS,QAAQ,WAAW,OAAO,CAAC,EAAE,IAAI,GAAG,SAAS;AAC7F,UAAM,YAAY,QAAQ,IAAI,MAAM,SAAS,QAAQ,WAAW,OAAO,CAAC,EAAE,IAAI,GAAG,SAAS;AAE1F,UAAM,QAAQ,EAAE,cAAc,GAAG,EAAE,GAAG,IAAI,EAAE,KAAK,IAAI,EAAE,IAAI;AAC3D,UAAM,YAAiB;AAAA,MACtB,WAAW;AAAA,MACX,YAAY,QAAQ,KAAK;AAAA,MACzB,oBAAoB,EAAE,KAAK,EAAE,KAAK,OAAO,EAAE,OAAO,MAAM,EAAE,KAAK;AAAA,MAC/D,QAAQ,OAAO,UAAU,OAAO,CAAC,EAAE,UAAU,CAAC;AAAA,MAC9C,QAAQ,OAAO,UAAU,OAAO,CAAC,EAAE,UAAU,CAAC;AAAA,MAC9C,YAAY,OAAO,UAAU,OAAO,CAAC,EAAE;AAAA,MACvC,YAAY,OAAO,UAAU,OAAO,CAAC,EAAE;AAAA,MACvC,UAAU;AAAA,QACT,QAAQ,EAAE,QAAQ,cAAc,QAAQ,UAAU;AAAA,MACnD;AAAA,IACD;AAEA,SAAK,IAAI,SAAS;AAAA,MACjB,MAAM;AAAA,MACN,QAAQ;AAAA,IACT,CAAC;AAAA,EACF;AAAA;AAAA;AAAA;AAAA,EAKA,oBAAoB,GAA2F;AAC9G,UAAM,SAAS,KAAK,IAAI,SAAS,EAAE,MAAM,KAAK,CAAC,MAAyB,EAAE,OAAO,KAAK,EAAE;AACxF,UAAM,qBAAqB,EAAE,cAAc,aAAa;AACxD,UAAM,cAAc,uBAAuB,SAAS,EAAE,WAAW,MAAM,GAAG,EAAE,CAAC,GAAG,KAAK,KAAK,KAAK;AAC/F,SAAK,IAAI,SAAS;AAAA,MACjB,MAAM;AAAA,MACN,QAAQ;AAAA,QACP,WAAW;AAAA,QACX,WAAW;AAAA,QACX,MAAM;AAAA,UACL,GAAG,EAAE,MAAM,aAAa;AAAA,UACxB,MAAM;AAAA,YACL;AAAA,YACA;AAAA,YACA,MAAM;AAAA,YACN,KAAK,EAAE;AAAA,YACP,OAAO,EAAE;AAAA,YACT,MAAM,EAAE;AAAA,UACT;AAAA,QACD;AAAA,QACA,OAAO;AAAA,UACN,GAAG,EAAE,QAAQ,OAAO,GAAG,EAAE,QAAQ,MAAM,mBAAmB;AAAA,UAC1D,MAAM,OAAO,GAAG;AAAA,QACjB;AAAA,MACD;AAAA,IACD,CAAC;AAAA,EACF;AAAA,EAEA,MAAM,sBAAsB;AAE3B,UAAM,YAAY,KAAK,gBAAgB,QAAQ,UAAU,SAAO,IAAI,UAAU,WAAW;AACzF,UAAM,oBAAoB,KAAK,gBAAgB,QAAQ,UAAU,SAAO,IAAI,UAAU,kBAAkB;AACxG,UAAM,aAAa,CAAC,GAAG,KAAK,gBAAgB,IAAI,EAAE,KAAK,CAAC,GAAG,MAAM;AAChE,YAAM,QAAQ,OAAO,EAAE,iBAAiB,EAAE,KAAK;AAC/C,YAAM,QAAQ,OAAO,EAAE,iBAAiB,EAAE,KAAK;AAC/C,aAAO,QAAQ;AAAA,IAChB,CAAC;AAGD,UAAM,WAAW,WAAW,MAAM,GAAG,GAAG,EAAE,IAAI,QAAM,EAAE,MAAM,EAAE,SAAS,EAAE,MAAM,EAAE;AAEjF,UAAM,MAAM,SAAS,IAAI,OAAK;AAC7B,YAAM,OAAO,EAAE;AACf,YAAM,OAAO,UAAU,KAAK,IAAI,QAAQ;AACxC,YAAM,OAAO,GAAG,IAAI,IAAI,IAAI;AAC5B,YAAM,OAAO,EAAE,MAAM,MAAM,MAAM,gBAAgB;AACjD,aAAO,EAAE,MAAM,GAAG,CAAC,EAAE;AAAA,IACtB,CAAC;AAED,UAAM,QAAQ,EAAE,KAAK,KAAK,MAAM,cAAc;AAC9C,UAAM,iBAAiB,KAAK,IAAI,SAAS,EAAE,MAAM,KAAK,CAAC,MAAW,EAAE,OAAO,KAAK,EAAE,EAAE;AACpF,UAAM,kBAAkB,EAAE,KAAK,CAAC,cAAc,EAAE;AAChD,UAAM,SAAS;AAAA,MACd,WAAW;AAAA,MACX,YAAY,CAAC,OAAO,eAAe;AAAA,MACnC,UAAU;AAAA,MACV,QAAQ;AAAA,QACP,IAAI;AAAA,QACJ,MAAM;AAAA,QACN,MAAM;AAAA,QACN,KAAK,CAAC,EAAE,MAAM,OAAO,KAAK,EAAE,MAAM,eAAe,KAAK,EAAE,CAAC;AAAA,MAC1D;AAAA,IACD;AACA,UAAM,KAAK,IAAI,SAAS;AAAA,MACvB,MAAM;AAAA,MACN,QAAQ,gBAAgB,MAAM;AAAA,IAC/B,CAAC;AAAA,EACF;AACD;;;ACzSO,IAAM,uBAAN,MAA2B;AAAA,EAGjC,YAAY,GAAmB,QAAmB,KAAW,cAAmC,UAAkB;AACjH,SAAK,WAAW;AAEhB,UAAM,WAAW;AAAA,MAChB;AAAA,QACC,OAAO;AAAA,QACP,WAAW,MAAM;AAChB,gBAAM,mBAAmB,oBAAI,IAAI,CAAC,iBAAiB,eAAe,CAAC;AACnE,iBAAO,iBAAiB,IAAI,QAAQ;AAAA,QACrC;AAAA,QACA,SAAS,YAAY;AACpB,cAAI,aAAa,gBAAiB,cAAa,oBAAoB,CAAQ;AAC3E,cAAI,aAAa,gBAAiB,cAAa,oBAAoB,EAAE,SAAS;AAAA,QAC/E;AAAA,MACD;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,WAAW,MAAM,aAAa;AAAA,QAC9B,SAAS,YAAY;AACpB,gBAAM,KAAK;AAOX,gBAAM,aAAa,UAAU;AAAA,YAC5B,KAAK,GAAG;AAAA,YACR,OAAO,GAAG;AAAA,YACV,MAAM,GAAG;AAAA,YACT,YAAY,GAAG;AAAA,UAChB,CAAC;AAAA,QACF;AAAA,MACD;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,WAAW,MAAM,aAAa;AAAA,QAC9B,SAAS,YAAY;AACpB,uBAAa,cAAc,EAAE,SAAS;AAAA,QACvC;AAAA,MACD;AAAA,IACD;AAMA,QAAI,QAAiC;AACrC,UAAM,gBAAgB,MAAM;AAC3B,UAAI,MAAO;AACX,YAAM,OAAO,OAAO,KAAK;AACzB,UAAI,CAAC,KAAM;AACX,YAAM,IAAI,KAAK,UAAU,IAAI;AAC7B,QAAE,aAAa,gBAAgB,KAAK;AAEpC,QAAE,aAAa,kBAAkB,MAAM;AACvC,WAAK,YAAY,YAAY,CAAC;AAC9B,cAAQ;AAAA,IACT;AACA,UAAM,gBAAgB,MAAM;AAC3B,UAAI,CAAC,MAAO;AACZ,YAAM,OAAO;AACb,cAAQ;AAAA,IACT;AAEA,WAAO,GAAG,cAAc,MAAM;AAE7B,UAAI,CAAC,EAAE,YAAa,eAAc;AAClC,UAAI,MAAM,EAAE,UAAU,OAAO,KAAK,CAAC;AACnC,YAAM,QAAQ,UAAU,EAAE,QAAQ,IAAI,EAAE,OAAO,OAAO,EAAE,CAAC;AACzD,WAAK,eAAe,GAAG,KAAK;AAAA,IAC7B,CAAC;AAED,QAAI,WAAW;AACf,WAAO,GAAG,cAAc,MAAM;AAC7B,UAAI,SAAU;AACd,UAAI,KAAK;AACT,oBAAc;AAAA,IACf,CAAC;AAED,UAAM,kBAAkB,SAAS,OAAO,SAAO,IAAI,UAAU,CAAC;AAC9D,QAAI,gBAAgB,WAAW,EAAG;AAElC,WAAO,GAAG,SAAS,MAAM;AACxB,iBAAW;AACX,UAAI,CAAC,EAAE,YAAa,eAAc;AAClC,UAAI,SAAS,MAAM;AAClB,mBAAW;AACX,sBAAc;AAAA,MACf;AACA,UAAI,MAAM,EAAE,UAAU,OAAO,KAAK,CAAC;AACnC,iBAAW,OAAO,iBAAiB;AAClC,YAAI,EACF,OAAO,KAAK,EACZ,KAAK,SAAS,gBAAgB,EAC9B,KAAK,IAAI,KAAK,EACd,GAAG,SAAS,YAAY;AACxB,cAAI,KAAK;AACT,wBAAc;AACd,gBAAM,IAAI,QAAQ;AAAA,QACnB,CAAC;AAAA,MACH;AAAA,IACD,CAAC;AAAA,EACF;AAAA,EAEA,eAAe,GAAmB,OAAY;AAC7C,QAAI,KAAK,aAAa,iBAAiB;AACtC,UAAI,iBAAiB,EAAG,MAAK,cAAc,OAAO,YAAY,EAAE,WAAW;AAC3E,UAAI,EAAE,UAAW,MAAK,cAAc,OAAO,WAAW,EAAE,SAAS;AAAA,IAClE,OAAO;AACN,WAAK,cAAc,OAAO,aAAa,EAAE,SAAS;AAAA,IACnD;AACA,SAAK,cAAc,OAAO,gCAAgC,eAAe,EAAE,WAAW,CAAC;AACvF,SAAK,cAAc,OAAO,oBAAoB,eAAe,EAAE,gBAAgB,CAAC;AAChF,SAAK,cAAc,OAAO,oBAAoB,eAAe,EAAE,gBAAgB,CAAC;AAAA,EACjF;AAAA,EAEA,cAAc,OAAY,MAAc,OAAwB;AAC/D,UAAM,CAAC,KAAK,GAAG,IAAI,MAAM,OAAO;AAChC,QAAI,KAAK,IAAI;AACb,QAAI,KAAK,KAAK;AAAA,EACf;AACD;;;ACzHO,IAAM,kBAAN,MAAsB;AAAA,EAQ5B,YAAY,KAAiB,cAAmC,UAAkB;AACjF,SAAK,MAAM;AACX,SAAK,eAAe;AACpB,SAAK,WAAW;AAChB,UAAM,UAAU,KAAK,IAAI,OACvB,OAAO,KAAK,EACZ,KAAK,MAAM,sBAAsB,EACjC,MAAM,WAAW,OAAO,EACxB,MAAM,WAAW,CAAC,EAClB,MAAM,YAAY,UAAU;AAC9B,UAAM,MAAM,KAAK,IAAI,OACnB,OAAO,KAAK,EACZ,MAAM,WAAW,cAAc,EAC/B,KAAK,MAAM,kBAAkB,EAC7B,MAAM,kBAAkB,KAAK;AAC/B,SAAK,aAAa;AAAA,MACjB;AAAA,MACA;AAAA,MACA,aAAa;AAAA,MACb,KAAK;AAAA,MACL,OAAO;AAAA,MACP,YAAY;AAAA,MACZ,OAAO;AAAA,MACP,YAAY;AAAA,MACZ,MAAM;AAAA,IACP;AAAA,EACD;AAAA,EAEA,OAAO,UAAoC,UAA2B;AACrE,SAAK,WAAW;AAChB,SAAK,WAAW;AAChB,UAAM,UAAU,KAAK,SAAS;AAE9B,SAAK,QAAQ;AAEb,SAAK,kBAAkB;AACvB,SAAK,WAAW,OAAO;AACvB,qBAAiB,IAAI;AACrB,SAAK,qBAAqB,OAAO;AACjC,QAAI,KAAK,SAAS,gBAAiB,MAAK,kBAAkB;AAAA,EAC3D;AAAA,EAEA,UAAU;AACT,SAAK,WAAW,QAAQ,UAAU,GAAG,EAAE,OAAO;AAC9C,SAAK,WAAW,IAAI,UAAU,GAAG,EAAE,OAAO;AAE1C,UAAM,MAAM,KAAK,WAAW;AAC5B,SAAK,WAAW,MAAM,IAAI,OAAO,GAAG,EAAE,KAAK,MAAM,kBAAkB;AACnE,SAAK,WAAW,QAAQ,IAAI,OAAO,GAAG,EAAE,KAAK,MAAM,oBAAoB;AACvE,SAAK,WAAW,QAAQ,IAAI,OAAO,GAAG,EAAE,KAAK,MAAM,oBAAoB;AACvE,SAAK,WAAW,aAAa,IAAI,OAAO,MAAM,EAAE,KAAK,MAAM,yBAAyB,EAAE,KAAK,eAAe,QAAQ;AAClH,SAAK,WAAW,aAAa,IAAI,OAAO,MAAM,EAAE,KAAK,MAAM,yBAAyB,EAAE,KAAK,eAAe,QAAQ;AAClH,SAAK,WAAW,OAAO,IAAI,OAAO,GAAG,EAAE,KAAK,MAAM,mBAAmB;AAErE,QAAI,CAAC,KAAK,SAAS,gBAAiB;AACpC,SAAK,WAAW,cAAc,KAAK,IAAI,OACrC,OAAO,KAAK,EACZ,KAAK,MAAM,0BAA0B,EACrC,KAAK,eAAe,0BAA0B,EAC9C,MAAM,WAAW,cAAc,EAC/B,MAAM,kBAAkB,KAAK;AAAA,EAChC;AAAA,EAEA,oBAAoB;AAEnB,SAAK,IAAI,WAAW,EAAE,MAAM,YAAY,QAAQ;AAChD,SAAK,WAAW,QAAQ,MAAM,eAAe,MAAM,EAAE,MAAM,WAAW,KAAK;AAC3E,SAAK;AAAA,MAAgB;AAAA,MAAuB,CAAC,iBAAiB,eAAe;AAAA,MAAG,MAC/E,KAAK,aAAa,gBAAgB;AAAA,IACnC;AACA,SAAK;AAAA,MAAgB;AAAA,MAAmB,CAAC,iBAAiB,qBAAqB,eAAe;AAAA,MAAG,MAChG,KAAK,aAAa,kBAAkB;AAAA,IACrC;AACA,SAAK,gBAAgB,cAAc,CAAC,iBAAiB,qBAAqB,eAAe,GAAG,MAAM;AACjG,WAAK,gBAAgB;AAAA,IACtB,CAAC;AACD,UAAM,WACL,KAAK,YAAY,kBAAkB,oCAAoC;AACxE,UAAM,cAAc,KAAK,SAAS,UAAU,KAAK,OAAK,EAAE,SAAS,QAAQ,GAAG;AAC5E,QAAI,aAAa;AAChB,YAAM,UAAU,KAAK,YAAY,kBAAkB,GAAG,WAAW,mBAAmB,GAAG,WAAW;AAClG,WAAK,WAAW,QAAQ,OAAO,MAAM,EAAE,KAAK,OAAO,EAAE,MAAM,eAAe,MAAM,EAAE,MAAM,eAAe,MAAM;AAE7G,WAAK,gBAAgB,sBAAsB,CAAC,iBAAiB,qBAAqB,eAAe,GAAG,YAAY;AAG/G,cAAM,YAAY,CAAC,KAAK,SAAS;AACjC,cAAM,KAAK,aAAa,IAAI,SAAS;AAAA,UACpC,MAAM;AAAA,UACN,IAAI,KAAK,aAAa;AAAA,UACtB,QAAQ,EAAE,UAAU,EAAE,SAAS,EAAE,iBAAiB,UAAU,EAAE,EAAE;AAAA,QACjE,CAAC;AAAA,MACF,CAAC;AAAA,IACF;AACA,QAAI,eAAe,eAAe,GAAG;AAEpC,WAAK;AAAA,QACJ,8BAA8B,cAAc,MAAM,YAAY,WAAW;AAAA,QACzE,CAAC,eAAe;AAAA,QAChB,YAAY;AACX,gBAAM,KAAK,aAAa,oBAAoB;AAAA,QAC7C;AAAA,MACD;AAAA,IACD;AAAA,EACD;AAAA;AAAA,EAGA,gBAAgB,MAAc,WAAqB,UAAe;AACjE,QAAI,KAAK,SAAS,YAAY,OAAO,IAAI,IAAI,EAAG;AAChD,QAAI,CAAC,UAAU,SAAS,KAAK,QAAQ,EAAG;AACxC,UAAM,SAAS,KAAK,WAAW,QAC7B,OAAO,QAAQ,EACf,KAAK,SAAS,gBAAgB,EAC9B,MAAM,UAAU,KAAK,EACrB,MAAM,WAAW,KAAK,EACtB,KAAK,IAAI,EACT,GAAG,SAAS,YAAY;AACxB,WAAK,IAAI,WAAW,MAAM,EAAE,UAAU,OAAO,KAAK,CAAC;AACnD,YAAM,SAAS;AAAA,IAChB,CAAC;AAAA,EACH;AAAA,EAEA,WAAW,SAAgC;AAC1C,SAAK,WAAW,IAAI,KAAK,SAAS,QAAQ,IAAI,KAAK,EAAE,KAAK,UAAU,QAAQ,IAAI,MAAM;AAEtF,SAAK,eAAe,OAAO;AAE3B,SAAK,WAAW,WAAW;AAAA,MAC1B;AAAA,MACA,aAAa,QAAQ,WAAW,CAAC,KAAK,QAAQ,WAAW,CAAC;AAAA,IAC3D;AACA,SAAK,qBAAqB,KAAK,WAAW,YAAY,QAAQ,MAAM,IAAI,KAAK,SAAS,UAAU,WAAW;AAE3G,SAAK,WAAW,WAAW,KAAK,aAAa,aAAa,QAAQ,WAAW,CAAC,KAAK,QAAQ,WAAW,CAAC,GAAG;AAC1G,SAAK,qBAAqB,KAAK,WAAW,YAAY,OAAO,KAAK,eAAe;AAEjF,SAAK,YAAY,QAAQ,MAAM;AAC/B,SAAK,YAAY,QAAQ,QAAQ,IAAI;AAMrC,QAAI,KAAK,SAAS,YAAY;AAC7B,WAAK,WAAW,KACd,OAAO,OAAO,EACd,KAAK,QAAQ,yBAAyB,KAAK,SAAS,UAAU,EAAE,EAChE,KAAK,KAAK,QAAQ,KAAK,CAAC,EACxB,KAAK,KAAK,QAAQ,KAAK,CAAC,EACxB,KAAK,SAAS,QAAQ,KAAK,KAAK,EAChC,KAAK,UAAU,QAAQ,KAAK,MAAM,EAClC,KAAK,uBAAuB,MAAM;AAAA,IACrC;AAEA,SAAK,WAAW,KACd,OAAO,MAAM,EACb,KAAK,SAAS,QAAQ,KAAK,KAAK,EAChC,KAAK,UAAU,QAAQ,KAAK,MAAM,EAClC,KAAK,UAAU,SAAS,EACxB,KAAK,QAAQ,aAAa,EAC1B,KAAK,mBAAmB,YAAY,EACpC,KAAK,aAAa,aAAa,QAAQ,KAAK,CAAC,KAAK,QAAQ,KAAK,CAAC,GAAG;AAAA,EACtE;AAAA,EAEA,eAAe,SAAS;AACvB,QAAI,KAAK,SAAS,YAAY,OAAW;AACzC,SAAK,WAAW,IAAI,KAAK,aAAa,aAAa,QAAQ,IAAI,CAAC,KAAK,QAAQ,IAAI,CAAC,GAAG;AAErF,UAAM,IAAI,KAAK,SAAS,SAAS;AACjC,UAAM,WAAW,UAAQ;AACxB,aACC,KAAK,WAAW,IACd,OAAO,MAAM,EACb,KAAK,aAAa,OAAO,EACzB,KAAK,aAAa,aAAa,KAAK,CAAC,KAAK,IAAI,EAAE,GAAG,EAEnD,KAAK,KAAK,KAAK;AAAA,IAEnB;AAUA,UAAM,YAAY,KAAK,SAAS,SAAS;AACzC,aAAS,SAAS;AAGlB,UAAM,aAAa,KAAK,SAAS,SAAS;AAE1C,UAAM,cAAc,SAAS,UAAU;AACvC,gBAAY,KAAK,eAAe,KAAK;AAAA,EACtC;AAAA,EAEA,YAAY,OAAY,SAAS,OAAO;AACvC,UAAM,SAAS,KAAK,WAAW,SAAS,UAAU,OAAO,EACvD,OAAO,GAAG,EACV,KAAK,aAAa,aAAa,MAAM,CAAC,KAAK,MAAM,CAAC,GAAG,EACrD,KAAK,SAAS,SAAS,MAAM,KAAK,IAAI,WAAW,MAAM,KAAK,CAAC;AAE/D,cAAU;AAAA,MACT,MAAM;AAAA,MACN,OAAO;AAAA,MACP,UAAU;AAAA,IACX,CAAC;AAAA,EACF;AAAA,EAEA,qBAAqB,SAAgC;AAEpD,SAAK,WAAW,KACd,OAAO,MAAM,EACb,KAAK,UAAU,MAAM,EACrB,KAAK,mBAAmB,YAAY,EACpC,KAAK,MAAM,QAAQ,kBAAkB,CAAC,EACtC,KAAK,MAAM,QAAQ,kBAAkB,CAAC,EACtC,KAAK,MAAM,QAAQ,kBAAkB,EAAE,EACvC,KAAK,MAAM,QAAQ,kBAAkB,EAAE;AAAA,EAC1C;AAAA,EAEA,kBAAkB;AAEjB,eAAW,OAAO,KAAK,SAAS,UAAU,CAAC,GAAG;AAC7C,WAAK,IAAI,WAAW,EAClB,OAAO,KAAK,EACZ,MAAM,WAAW,cAAc,EAC/B,MAAM,eAAe,MAAM,EAC3B,MAAM,cAAc,OAAO,EAC3B,KAAK,SAAS,GAAG,EACjB,KAAK,UAAU,GAAG,EAClB,KAAK,OAAO,IAAI,GAAG;AAAA,IACtB;AACA,UAAM,cAAc,KAAK,IAAI,WAAW,EACtC,OAAO,KAAK,EAEZ,MAAM,WAAW,KAAK,SAAS,OAAO,UAAU,IAAI,iBAAiB,OAAO,EAI5E,MAAM,UAAU,GAAG,KAAK,SAAS,OAAO,UAAU,IAAI,cAAc,SAAS,UAAU,EACvF,MAAM,kBAAkB,KAAK;AAC/B,UAAM,QAAQ,UAAU,EAAE,QAAQ,YAAY,CAAC;AAC/C,eAAW,KAAK,KAAK,SAAS,WAAW;AACxC,YAAM,CAAC,KAAK,GAAG,IAAI,MAAM,OAAO;AAChC,UAAI,KAAK,EAAE,KAAK;AAChB,UAAI,MAAM,cAAc,KAAK,EAAE,KAAK,EAAE,KAAK;AAAA,IAC5C;AAAA,EACD;AAAA,EAEA,oBAAoB;AACnB,QAAI,CAAC,KAAK,SAAS,gBAAiB;AAGpC,UAAM,eAAe;AACrB,UAAM,UAAU,KAAK,SAAS,gBAAgB;AAC9C,UAAM,OAAO,QAAQ,SAAS,eAAe,QAAQ,MAAM,GAAG,YAAY,IAAI;AAC9E,QAAI,QAAQ,SAAS,cAAc;AAClC,WAAK,WAAW,YACd,OAAO,KAAK,EACZ,MAAM,WAAW,UAAU,EAC3B,MAAM,aAAa,MAAM,EACzB,MAAM,SAAS,MAAM,EACrB;AAAA,QACA,eAAe,aAAa,eAAe,CAAC,OAAO,QAAQ,OAAO,eAAe,CAAC;AAAA,MACnF;AAAA,IACF;AACA,gBAAY;AAAA,MACX,SAAS,KAAK,SAAS,gBAAgB;AAAA,MACvC;AAAA,MACA,KAAK,KAAK,WAAW;AAAA,MACrB,WAAW;AAAA,MACX,WAAW,GAAG,KAAK,SAAS,gBAAgB,MAAM;AAAA,MAClD,QAAQ;AAAA,MACR,QAAQ,EAAE,WAAW,KAAK;AAAA,MAC1B,YAAY;AAAA,MACZ,kBAAkB,CAAC,MAAc;AAGhC,cAAM,OAAO,KAAK,SAAS,gBAAgB,KAAK,CAAC,EAAE,CAAC,EAAE;AACtD,YAAI,CAAC,KAAM;AACX,aAAK,aAAa,mBAAmB,IAAI;AAAA,MAC1C;AAAA,MACA,cAAc,CAAC,IAAI,QAAQ;AAK1B,cAAM,UAAU,KAAK,WAAW,KAAK,UAAU,QAAQ,EAAE,MAAM;AAC/D,cAAM,UAAU,KAAK,aAAa,kBAAkB,gBAAgB;AACpE,cAAM,SAAS,QAAQ,KAAK,CAAC,MAAW,EAAE,SAAS,OAAO,KAAK,IAAI,CAAC,EAAE,KAAK;AAC3E,YAAI,CAAC,UAAU,OAAO,SAAS,YAAa;AAK5C,YAAI;AACJ,WAAG,GAAG,aAAa,MAAM;AACxB,cAAI,OAAO,SAAS,eAAe,MAAO;AAC1C,kBAAQ,KAAK,WAAW,KAAK,KAAK,GAAG,YAAY,OAAO,UAAU,IAAI,CAAC;AACvE,gBAAM,aAAa,gBAAgB,GAAG;AAAA,QACvC,CAAC;AACD,WAAG,GAAG,cAAc,MAAM;AACzB,cAAI,CAAC,MAAO;AACZ,gBAAM,OAAO;AACb,kBAAQ;AAAA,QACT,CAAC;AAED,aAAK,WAAW,YAAY,GAAG,aAAa,MAAM;AACjD,4BAAU,OAAO,EAAE,KAAK,kBAAkB,KAAK;AAAA,QAChD,CAAC;AACD,aAAK,WAAW,YAAY,GAAG,cAAc,MAAM;AAClD,4BAAU,OAAO,EAAE,KAAK,kBAAkB,CAAC,MAAY,EAAE,cAAc,OAAO,GAAI;AAAA,QACnF,CAAC;AAAA,MACF;AAAA,IACD,CAAC;AAAA,EACF;AAAA,EAEA,qBAAqB,UAAe,QAAgB,WAAmB,QAAgB;AACtF,aAAS,KAAK,IAAI;AAClB,aAAS,OAAO,OAAO,EAAE,KAAK,MAAM;AACpC,aAAS,OAAO,OAAO,EAAE,KAAK,kBAAkB,KAAK,EAAE,KAAK,aAAa,OAAO,EAAE,KAAK,SAAS;AAChG,aAAS,OAAO,OAAO,EAAE,KAAK,MAAM;AAAA,EACrC;AACD;AAEA,SAAS,iBAAiB,MAAW;AACpC,OAAK,WAAW,KACd,UAAU,QAAQ,EAClB,KAAK,KAAK,SAAS,SAAS,EAC5B,MAAM,EACN,OAAO,QAAQ,EACf,KAAK,UAAU,CAAC,MAAsB,IAAI,EAAE,KAAK,EAAE,UAAU,CAAC,EAC9D,KAAK,kBAAkB,CAAC,MAAuB,EAAE,cAAc,OAAO,GAAI,EAC1E,KAAK,gBAAgB,CAAC,MAAuB,EAAE,cAAc,MAAM,CAAE,EACrE,KAAK,QAAQ,KAAK,SAAS,qBAAqB,EAChD,KAAK,gBAAgB,CAAC,MAAuB,EAAE,cAAc,MAAM,CAAE,EACrE,KAAK,MAAM,CAAC,MAAsB,EAAE,CAAC,EACrC,KAAK,MAAM,CAAC,MAAsB,EAAE,CAAC,EACrC,KAAK,KAAK,CAAC,MAAsB,EAAE,MAAM,EACzC,KAAK,SAAqB,GAAmB;AAC7C,UAAM,SAAS,eAAO,IAAI;AAC1B,QAAI,qBAAqB,GAAG,QAAQ,KAAK,IAAI,KAAK,KAAK,cAAc,KAAK,QAAQ;AAAA,EACnF,CAAC;AACH;;;ACzVO,IAAM,uBAAN,MAA2B;AAAA,EAOjC,YAAY,QAA2B,UAAkB;AACxD,SAAK,SAAS;AACd,QAAI,KAAK,OAAO,YAAY,gBAAiB,MAAK,YAAY,aAAa,MAAM;AACjF,SAAK,WAAW;AAEhB,SAAK,SAAS;AAAA,MACb;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,KAAK;AAAA;AAAA;AAAA;AAAA,QAIL,KAAK;AAAA,QACL,MAAM;AAAA,MACP;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,SAAS;AAAA,UACR,EAAE,OAAO,YAAY,OAAO,WAAW;AAAA,UACvC,EAAE,OAAO,YAAY,OAAO,WAAW;AAAA,QACxC;AAAA,MACD;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,KAAK;AAAA,QACL,KAAK;AAAA,MACN;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OACC;AAAA,QACD,KAAK;AAAA,QACL,KAAK;AAAA,QACL,MAAM;AAAA,MACP;AAAA;AAAA;AAAA,MAGA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,KAAK;AAAA,QACL,KAAK;AAAA,MACN;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,KAAK;AAAA,QACL,KAAK;AAAA,MACN;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,OAAO;AAAA,QACP,aAAa;AAAA,QACb,iBAAiB,MAAM;AACtB,cAAI,KAAK,OAAO,YAAY,oBAAqB,QAAO;AACxD,gBAAM,eAAe,KAAK,OAAO,IAAI,MAAM,SAAS,KAAK,OAAO,UAAU,OAAO,CAAC,EAAE,IAAI,GAAG;AAC3F,gBAAM,YAAY,KAAK,OAAO,IAAI,MAAM,SAAS,KAAK,OAAO,UAAU,OAAO,CAAC,EAAE,IAAI,EAAE;AACvF,cAAI,gBAAgB,UAAW,QAAO;AAAA,cACjC,QAAO;AAAA,QACb;AAAA,MACD;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,OAAO;AAAA,QACP,aAAa;AAAA,MACd;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,OAAO;AAAA,QACP,aAAa;AAAA,MACd;AAAA,IACD;AAEA,SAAK,wBAAwB;AAAA,EAC9B;AAAA;AAAA,EAGA,0BAA0B;AACzB,SAAK,wBAAwB;AAC7B,SAAK,wBAAwB;AAC7B,SAAK,6BAA6B;AAAA,EACnC;AAAA,EAEA,0BAA0B;AACzB,QAAI,KAAK,aAAa,gBAAiB;AACvC,UAAM,WAAW;AAAA,MAChB;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,KAAK;AAAA,QACL,KAAK;AAAA,MACN;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,KAAK;AAAA,QACL,KAAK;AAAA,MACN;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,KAAK;AAAA,MACN;AAAA,MACA;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,SAAS,KAAK,iBAAiB;AAAA,MAChC;AAAA;AAAA;AAAA;AAAA;AAAA;AAAA;AAAA;AAAA;AAAA;AAAA;AAAA;AAAA;AAAA;AAAA,IAcD;AAEA,SAAK,OAAO,OAAO,GAAG,GAAG,GAAG,QAAQ;AAAA,EACrC;AAAA,EAEA,0BAA0B;AACzB,QAAI,KAAK,aAAa,gBAAiB;AACvC,UAAM,WAAW;AAAA,MAChB;AAAA,QACC,OAAO;AAAA,QACP,MAAM;AAAA,QACN,WAAW;AAAA,QACX,aAAa;AAAA,QACb,OAAO;AAAA,QACP,KAAK;AAAA,QACL,KAAK;AAAA,MACN;AAAA,IACD;AACA,SAAK,OAAO,OAAO,GAAG,GAAG,GAAG,QAAQ;AAAA,EACrC;AAAA,EAEA,+BAA+B;AAC9B,QAAI,KAAK,aAAa,oBAAqB;AAE3C,UAAM,aAAa,CAAC;AAEpB,SAAK,OAAO,OAAO,GAAG,GAAG,GAAG,UAAU;AAAA,EACvC;AAAA,EAEA,mBAAmB;AAClB,QAAI,KAAK,aAAa,gBAAiB;AACvC,UAAM,WAAW,KAAK,OAAO,SAAS;AACtC,UAAM,WAAW,KAAK,MAAM,eAAe,QAAQ,kBAAkB,CAAW;AAChF,QAAI,UAAU,eAAe,QAAQ;AACpC,YAAM,OAA2C,CAAC;AAClD,iBAAW,KAAK,SAAS,eAAe;AACvC,aAAK,KAAK,EAAE,OAAO,GAAG,OAAO,EAAE,YAAY,EAAE,CAAC;AAAA,MAC/C;AACA,aAAO;AAAA,IACR;AACA,QAAI,KAAK,YAAa,SAAU,iBAAiB;AAChD,aAAO;AAAA,QACN,EAAE,OAAO,SAAS,OAAO,QAAQ;AAAA,QACjC,EAAE,OAAO,YAAY,OAAO,WAAW;AAAA,QACvC,EAAE,OAAO,SAAS,OAAO,QAAQ;AAAA,MAClC;AAAA,IACD,MAAO,QAAO,CAAC,EAAE,OAAO,YAAY,OAAO,WAAW,CAAC;AAAA,EACxD;AACD;;;AC3NA,IAAM,UAAN,MAAM,iBAAgB,SAAgC;AAAA,EACrD;AAAA,SAAO,OAAO;AAAA;AAAA,EASd,YAAY,MAAmB,KAAK;AACnC,UAAM,MAAM,GAAG;AACf,QAAI,KAAK,KAAK,SAAU,MAAK,WAAW,KAAK,KAAK;AAClD,SAAK,OAAO,SAAQ;AACpB,SAAK,aAAa;AAAA,MACjB,UAAU,CAAC;AAAA,IACZ;AAEA,SAAK,WAAW,KAAK;AACrB,UAAM,SAAS,KAAK,OAClB,QAAQ,qBAAqB,IAAI,EACjC,KAAK,eAAe,qBAAqB,KAAK,QAAQ,EAAE;AAE1D,UAAM,WAAW,OAAO,KAAK,YAAY,WAAW,KAAK,WAAW,UAAW,OAAe,OAAO,KAAK;AAC1G,UAAM,QAAQ,KAAK,OACjB,OAAO,KAAK,EACZ,KAAK,MAAM,oBAAoB,EAC/B,KAAK,eAAe,sBAAsB,KAAK,QAAQ,EAAE,EACzD,MAAM,WAAW,IAAI;AACvB,SAAK,MAAM;AAAA,MACV;AAAA,MACA;AAAA,MACA;AAAA,MACA,MAAM,OACJ,OAAO,KAAK,EACZ,KAAK,MAAM,mBAAmB,EAC9B,KAAK,eAAe,qBAAqB,KAAK,QAAQ,EAAE,EACxD,MAAM,WAAW,IAAI,EACrB,MAAM,WAAW,MAAM,EACvB,KAAK,YAAY;AAAA,MACnB,KAAK,IAAI,KAAK,EAAE,SAAS,GAAG,CAAC;AAAA,MAC7B,YAAY,IAAI,KAAK,EAAE,SAAS,GAAG,CAAC;AAAA,IACrC;AAAA,EACD;AAAA,EAEA,SAAS,UAAqB;AAC7B,UAAM,SAAc,SAAS,MAAM,KAAK,CAAC,MAAsB,EAAE,OAAO,KAAK,EAAE;AAC/E,QAAI,CAAC,QAAQ;AACZ,YAAM,IAAI;AAAA,QACT,oBAAoB,KAAK,EAAE;AAAA,MAC5B;AAAA,IACD;AACA,UAAM,eAAoB,KAAK,YAAY,SAAS,MAAM,KAAK,OAAK,EAAE,OAAO,KAAK,QAAQ;AAC1F,UAAM,aAAa,sBAAsB,UAAU,OAAO,UAAU,cAAc,MAAM;AAExF,WAAO;AAAA,MACN,QAAQ,OAAO,OAAO,CAAC,GAAG,QAAQ;AAAA,QACjC,UAAU;AAAA,UACT,SAAS,OAAO,SAAS;AAAA,QAC1B;AAAA,MACD,CAAC;AAAA,MACD;AAAA,IACD;AAAA,EACD;AAAA,EAEA,MAAM,cAAc;AACnB,UAAM,aAAa,KAAK,IAAI,SAAS,EAAE,MAAM,KAAK,CAAC,MAAW,EAAE,OAAO,KAAK,EAAE;AAC9E,UAAM,WAAW,IAAI,qBAAqB,YAAY,KAAK,QAAQ;AAEnE,SAAK,WAAW,WAAW,MAAM,aAAa;AAAA,MAC7C,KAAK,KAAK;AAAA,MACV,IAAI,KAAK;AAAA,MACT,QAAQ,KAAK,IAAI,SAAS,MAAM,WAAW,cAAc;AAAA,MACzD,QAAQ,SAAS;AAAA,IAClB,CAAC;AAED,SAAK,WAAW,SAAS,GAAG,yBAAyB,MAAM,KAAK,aAAc,SAAS,KAAK,QAAQ,CAAC;AACrG,QAAI,WAAW,aAAa;AAC3B,WAAK,WAAW,SAAS;AAAA,QAAG;AAAA,QAAkC;AAAA;AAAA;AAAA,UAG7D,OAAO,KAAK,mEAAmE;AAAA;AAAA,MAChF;AAAA,EACF;AAAA,EAEA,MAAM,OAAO;AACZ,SAAK,eAAe,IAAI,oBAAoB,KAAK,KAAK,KAAK,IAAI,KAAK,GAAG;AACvE,SAAK,QAAQ,IAAI,aAAa,KAAK,KAAK,KAAK,QAAQ;AACrD,SAAK,OAAO,IAAI,gBAAgB,KAAK,KAAK,KAAK,cAAc,KAAK,QAAQ;AAC1E,UAAM,KAAK,YAAY;AAAA,EACxB;AAAA,EAEA,MAAM,OAAO;AACZ,QAAI,CAAC,KAAK,aAAc,OAAM,IAAI,MAAM,sCAAsC;AAC9E,QAAI,CAAC,KAAK,MAAO,OAAM,IAAI,MAAM,+BAA+B;AAChE,QAAI,CAAC,KAAK,KAAM,OAAM,IAAI,MAAM,8BAA8B;AAE9D,UAAM,SAAS,gBAAgB,KAAK,MAAM,MAAM;AAEhD,QAAI,OAAO,aAAa,KAAK,QAAQ,OAAO,aAAa,KAAK,KAAM;AAEpE,UAAM,WAAW,OAAO,SAAS;AACjC,QAAI;AAEH,YAAM,WAAW,WAAW,MAAM;AACjC,aAAK,IAAI,KAAK,MAAM,WAAW,OAAO;AAAA,MACvC,GAAG,GAAG;AAGN,YAAM,WAAW,MAAM,KAAK,MAAM,QAAQ,QAAQ,QAAQ;AAC1D,WAAK,IAAI,MAAM,KAAK,EAAE;AACtB,UAAI,CAAC,YAAY,SAAS,SAAS,CAAC,SAAS,QAAQ,CAAC,SAAS,KAAK,cAAc,CAAC,SAAS,KAAK,WAAW;AAC3G,iBAAS,KAAK,IAAI,OAAO,UAAU,SAAS,8BAA8B;AAC1E,qBAAa,QAAQ;AACrB,aAAK,IAAI,KAAK,MAAM,WAAW,MAAM;AACrC;AAAA,MACD;AAGA,YAAM,YAAY,IAAI,iBAAiB,QAAQ,UAAU,QAAQ;AAEjE,WAAK,aAAa,kBAAkB,UAAU,SAAS;AACvD,WAAK,aAAa,OAAO,SAAS,KAAK;AAGvC,WAAK,KAAK,OAAO,UAAU,UAAU,QAAQ;AAE7C,UAAI,CAAC,SAAS,KAAK,KAAK,QAAQ;AAC/B,aAAK,IAAI,MAAM,KAAK,8CAA8C,EAAE,MAAM,SAAS,MAAM;AAAA,MAC1F;AAEA,mBAAa,QAAQ;AACrB,WAAK,IAAI,KAAK,MAAM,WAAW,MAAM;AAAA,IACtC,SAAS,GAAQ;AAChB,UAAI,aAAa,MAAO,SAAQ,MAAM,EAAE,WAAW,CAAC;AAAA,eAC3C,EAAE,MAAO,SAAQ,IAAI,EAAE,KAAK;AACrC,YAAM;AAAA,IACP;AAAA,EACD;AACD;AAEO,IAAM,cAAc,YAAY,OAAO;AACvC,IAAM,gBAAgB;AAE7B,eAAsB,cAAc,MAAW,KAAa;AAC3D,MAAI,CAAC,KAAK,SAAU,OAAM,IAAI,MAAM,uBAAuB;AAE3D,QAAM,SAAS;AAAA,IACd,UAAU;AAAA,MACT,SAAS,0BAA0B,KAAK,WAAW,IAAI;AAAA,IACxD;AAAA,IACA,iBAAiB,KAAK,mBAAmB,CAAC;AAAA,IAC1C,UAAU,KAAK;AAAA,EAChB;AAGA,MAAI,KAAK,YAAY,iBAAiB;AACrC,QAAI,KAAK,eAAe;AACvB,UAAI;AACH,mBAAW,MAAM,KAAK,eAAe;AACpC,gBAAM,gBAAgB,IAAI,IAAI,QAAQ;AAAA,QACvC;AAAA,MACD,SAAS,GAAQ;AAChB,gBAAQ,MAAM,EAAE,WAAW,CAAC;AAC5B,cAAM,IAAI,MAAM,oEAAoE,CAAC,EAAE;AAAA,MACxF;AAAA,IACD;AACA,WAAO,OAAO,QAAQ;AAAA,MACrB,eAAe,KAAK,iBAAiB,CAAC;AAAA,MACtC,WAAW,KAAK;AAAA,IACjB,CAAC;AAAA,EACF;AAGA,MAAI,KAAK,YAAY,qBAAqB;AACzC,WAAO,OAAO,QAAQ;AAAA;AAAA,MAErB,QAAQ,KAAK,gBAAgB,KAAK,UAAU,KAAK,UAAU,CAAC,GAAG,YAAY,CAAC,GAAG;AAAA,MAC/E,QAAQ,IAAI,SAAS,aAAa,QAAQ,WAAW,QAAQ;AAAA;AAAA;AAAA,MAG7D,cAAc,KAAK,gBAAgB;AAAA,IACpC,CAAC;AAAA,EACF;AAGA,0BAAwB,QAAQ,IAAI;AAEpC,SAAO,UAAU,QAAQ,IAAI;AAC9B;",
+  "names": []
+}