datacite-mapping 0.1.15 → 0.1.16

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Files changed (144) hide show
  1. checksums.yaml +4 -4
  2. data/CHANGES.md +5 -0
  3. data/README.md +21 -0
  4. data/datacite-mapping.gemspec +1 -1
  5. data/lib/datacite/mapping/date.rb +2 -2
  6. data/lib/datacite/mapping/identifier.rb +19 -3
  7. data/lib/datacite/mapping/module_info.rb +1 -1
  8. data/lib/datacite/mapping/nonvalidating/identifier.rb +40 -0
  9. data/lib/datacite/mapping/nonvalidating/subject.rb +43 -0
  10. data/lib/datacite/mapping/nonvalidating.rb +10 -0
  11. data/lib/datacite/mapping/resource.rb +19 -14
  12. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3059p-mrt-datacite.xml +42 -0
  13. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r31017-mrt-datacite.xml +37 -0
  14. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3201j-mrt-datacite.xml +50 -0
  15. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r33w26-mrt-datacite.xml +45 -0
  16. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r34s3v-mrt-datacite.xml +35 -0
  17. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r36p4t-mrt-datacite.xml +53 -0
  18. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r39g6f-mrt-datacite.xml +68 -0
  19. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3cc7d-mrt-datacite.xml +42 -0
  20. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3d59d-mrt-datacite.xml +45 -0
  21. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3f59q-mrt-datacite.xml +68 -0
  22. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3g591-mrt-datacite.xml +35 -0
  23. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3k016-mrt-datacite.xml +68 -0
  24. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3kw2j-mrt-datacite.xml +58 -0
  25. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3mw2v-mrt-datacite.xml +33 -0
  26. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3np4v-mrt-datacite.xml +40 -0
  27. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3pp45-mrt-datacite.xml +47 -0
  28. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3rp4s-mrt-datacite.xml +34 -0
  29. data/spec/data/dash1-datacite-xml/dataone-ark+=c5146=r3tg63-mrt-datacite.xml +36 -0
  30. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d1159q-mrt-datacite.xml +53 -0
  31. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d17g6j-mrt-datacite.xml +50 -0
  32. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d1c88g-mrt-datacite.xml +47 -0
  33. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d1cc74-mrt-datacite.xml +71 -0
  34. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d1h019-mrt-datacite.xml +38 -0
  35. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d1ms3x-mrt-datacite.xml +42 -0
  36. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d1mw2k-mrt-datacite.xml +39 -0
  37. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d1rg66-mrt-datacite.xml +39 -0
  38. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d1rp4h-mrt-datacite.xml +53 -0
  39. data/spec/data/dash1-datacite-xml/ucb-ark+=b6078=d1wc7s-mrt-datacite.xml +49 -0
  40. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1001p-mrt-datacite.xml +51 -0
  41. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1059f-mrt-datacite.xml +65 -0
  42. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d11010-mrt-datacite.xml +49 -0
  43. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1159r-mrt-datacite.xml +79 -0
  44. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d12019-mrt-datacite.xml +60 -0
  45. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d12s30-mrt-datacite.xml +51 -0
  46. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1301m-mrt-datacite.xml +66 -0
  47. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d13s39-mrt-datacite.xml +49 -0
  48. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d13w2z-mrt-datacite.xml +60 -0
  49. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d14s3m-mrt-datacite.xml +64 -0
  50. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d15k5m-mrt-datacite.xml +66 -0
  51. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d15p48-mrt-datacite.xml +60 -0
  52. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d16k5x-mrt-datacite.xml +49 -0
  53. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d16p4k-mrt-datacite.xml +62 -0
  54. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d17g6k-mrt-datacite.xml +50 -0
  55. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d17p4w-mrt-datacite.xml +69 -0
  56. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d18g6w-mrt-datacite.xml +69 -0
  57. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1988w-mrt-datacite.xml +66 -0
  58. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d19g66-mrt-datacite.xml +74 -0
  59. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1b886-mrt-datacite.xml +53 -0
  60. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1bc7v-mrt-datacite.xml +67 -0
  61. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1c88h-mrt-datacite.xml +59 -0
  62. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1cc75-mrt-datacite.xml +62 -0
  63. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1d595-mrt-datacite.xml +50 -0
  64. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1f30c-mrt-datacite.xml +115 -0
  65. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1f59g-mrt-datacite.xml +71 -0
  66. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1g011-mrt-datacite.xml +52 -0
  67. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1g59s-mrt-datacite.xml +81 -0
  68. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1h01b-mrt-datacite.xml +66 -0
  69. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1h593-mrt-datacite.xml +62 -0
  70. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1j01n-mrt-datacite.xml +60 -0
  71. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1js3b-mrt-datacite.xml +55 -0
  72. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1k01z-mrt-datacite.xml +67 -0
  73. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1ks3n-mrt-datacite.xml +50 -0
  74. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1kw29-mrt-datacite.xml +82 -0
  75. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1ms3z-mrt-datacite.xml +48 -0
  76. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1mw2m-mrt-datacite.xml +67 -0
  77. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1np4m-mrt-datacite.xml +51 -0
  78. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1pk58-mrt-datacite.xml +47 -0
  79. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1pp4x-mrt-datacite.xml +67 -0
  80. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1qg6x-mrt-datacite.xml +53 -0
  81. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1qp47-mrt-datacite.xml +68 -0
  82. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1rg67-mrt-datacite.xml +48 -0
  83. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1rp4j-mrt-datacite.xml +70 -0
  84. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1sg6j-mrt-datacite.xml +85 -0
  85. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1t88j-mrt-datacite.xml +53 -0
  86. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1tg6v-mrt-datacite.xml +66 -0
  87. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1v88v-mrt-datacite.xml +53 -0
  88. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1vc7h-mrt-datacite.xml +64 -0
  89. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1w885-mrt-datacite.xml +50 -0
  90. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1wc7t-mrt-datacite.xml +71 -0
  91. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1x59t-mrt-datacite.xml +47 -0
  92. data/spec/data/dash1-datacite-xml/uci-ark+=b7280=d1z594-mrt-datacite.xml +62 -0
  93. data/spec/data/dash1-datacite-xml/ucla-ark+=b5060=d2qr4v2t-mrt-datacite.xml +57 -0
  94. data/spec/data/dash1-datacite-xml/ucla-ark+=b5068=d1cc7x-mrt-datacite.xml +41 -0
  95. data/spec/data/dash1-datacite-xml/ucla-ark+=b5068=d1h59v-mrt-datacite.xml +33 -0
  96. data/spec/data/dash1-datacite-xml/ucla-ark+=b5068=d1rp49-mrt-datacite.xml +36 -0
  97. data/spec/data/dash1-datacite-xml/ucla-ark+=b5068=d1wc7k-mrt-datacite.xml +46 -0
  98. data/spec/data/dash1-datacite-xml/ucm-ark+=13030=m51g217t-mrt-datacite.xml +28 -0
  99. data/spec/data/dash1-datacite-xml/ucm-ark+=b6071=z7wc73-mrt-datacite.xml +83 -0
  100. data/spec/data/dash1-datacite-xml/ucop-ark+=b5060=d8301x-mrt-datacite.xml +39 -0
  101. data/spec/data/dash1-datacite-xml/ucop-ark+=b5060=d86p4w-mrt-datacite.xml +38 -0
  102. data/spec/data/dash1-datacite-xml/ucop-ark+=b5060=d8bc75-mrt-datacite.xml +40 -0
  103. data/spec/data/dash1-datacite-xml/ucop-ark+=b5060=d8g593-mrt-datacite.xml +39 -0
  104. data/spec/data/dash1-datacite-xml/ucop-ark+=b5060=d8h59d-mrt-datacite.xml +53 -0
  105. data/spec/data/dash1-datacite-xml/ucop-ark+=b5060=d8kw2m-mrt-datacite.xml +39 -0
  106. data/spec/data/dash1-datacite-xml/ucop-ark+=b5060=d8rp4v-mrt-datacite.xml +52 -0
  107. data/spec/data/dash1-datacite-xml/ucop-ark+=b5060=d8z59f-mrt-datacite.xml +42 -0
  108. data/spec/data/dash1-datacite-xml/ucsc-ark+=b7291=d11592-mrt-datacite.xml +38 -0
  109. data/spec/data/dash1-datacite-xml/ucsc-ark+=b7291=d17p46-mrt-datacite.xml +43 -0
  110. data/spec/data/dash1-datacite-xml/ucsc-ark+=b7291=d1h59d-mrt-datacite.xml +43 -0
  111. data/spec/data/dash1-datacite-xml/ucsc-ark+=b7291=d1mw2x-mrt-datacite.xml +54 -0
  112. data/spec/data/dash1-datacite-xml/ucsc-ark+=b7291=d1wc74-mrt-datacite.xml +55 -0
  113. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6057cv6-mrt-datacite.xml +96 -0
  114. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6154f00-mrt-datacite.xml +73 -0
  115. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q61z429d-mrt-datacite.xml +29 -0
  116. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q62z13fs-mrt-datacite.xml +43 -0
  117. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q65q4t1r-mrt-datacite.xml +25 -0
  118. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q66q1v54-mrt-datacite.xml +42 -0
  119. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q67p8w9z-mrt-datacite.xml +63 -0
  120. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q68g8hmp-mrt-datacite.xml +24 -0
  121. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6bg2kwf-mrt-datacite.xml +63 -0
  122. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6c8276k-mrt-datacite.xml +43 -0
  123. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6cc0xmh-mrt-datacite.xml +63 -0
  124. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6d798bd-mrt-datacite.xml +26 -0
  125. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6h12zxh-mrt-datacite.xml +46 -0
  126. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6h41pb7-mrt-datacite.xml +60 -0
  127. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6kw5cxv-mrt-datacite.xml +43 -0
  128. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6ms3qnx-mrt-datacite.xml +42 -0
  129. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6mw2f2n-mrt-datacite.xml +61 -0
  130. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6pn93h6-mrt-datacite.xml +52 -0
  131. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6qn64nk-mrt-datacite.xml +46 -0
  132. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6rf5rzx-mrt-datacite.xml +60 -0
  133. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6rn35sz-mrt-datacite.xml +63 -0
  134. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6sf2t3q-mrt-datacite.xml +21 -0
  135. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6td9v7j-mrt-datacite.xml +29 -0
  136. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6w66hpn-mrt-datacite.xml +23 -0
  137. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6x63jt1-mrt-datacite.xml +27 -0
  138. data/spec/data/dash1-datacite-xml/ucsf-ark+=b7272=q6z60kzd-mrt-datacite.xml +45 -0
  139. data/spec/data/metadata.xsd +380 -0
  140. data/spec/data/mrt-datacite.xml +61 -0
  141. data/spec/unit/datacite/mapping/date_spec.rb +23 -15
  142. data/spec/unit/datacite/mapping/nonvalidating/identifier_spec.rb +38 -0
  143. data/spec/unit/datacite/mapping/resource_spec.rb +69 -12
  144. metadata +267 -4
@@ -0,0 +1,29 @@
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+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
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+ <identifier identifierType="DOI"/>
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+ <creators>
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+ <creator><creatorName>Greninger, Alexander</creatorName></creator>
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+ <creator><creatorName>DeRisi, Joseph</creatorName></creator>
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+ </creators>
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+ <titles>
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+ <title>Pooled metagenomic sequence from human stool</title>
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+ </titles>
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+ <publisher>University of California, San Francisco</publisher>
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+ <publicationYear>2014</publicationYear>
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+ <subjects>
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+ <subject>Metagenomics</subject>
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+ <subject>Viral sequence</subject>
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+ <subject>Klassevirus</subject>
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+ </subjects>
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+ <contributors>
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+ <contributor contributorType="ResearchGroup"><contributorName>UCSF</contributorName></contributor>
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+ </contributors>
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+ <resourceType resourceTypeGeneral="Dataset">Dataset</resourceType>
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+ <descriptions>
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+ <description descriptionType="Abstract">This dataset corresponds to the data presented in &quot;The complete genome of klassevirus – a novel picornavirus in pediatric stool&quot; by Greninger et al (http://www.ncbi.nlm.nih.gov/pubmed/19538752).</description>
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+ <description descriptionType="Methods">141 diarrhea samples were prepared, pooled, and pyrosequenced on the Roche Genome Sequence FLX as described in &quot;The complete genome of klassevirus – a novel picornavirus in pediatric stool&quot; by Greninger et al (http://www.ncbi.nlm.nih.gov/pubmed/19538752). A novel member of the Picornaviridae viral family, Human klassevirus 1, was discovered in the 540,412 unique reads with an average length of 240 nt. The reads were stripped of sequences mapping with 90% or greater identity to known diarrhea-causing viruses: 6,959 reads mapped to the Adenoviridae and Caliciviridae viral families by translated BLAST. Of the remaining 533,453 unique reads, 483 derived from Human klassevirus 1. The data are provided in FASTA format.</description>
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+ <description descriptionType="SeriesInformation">The complete genome of klassevirus - a novel picornavirus in pediatric stool.
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+ Greninger AL, Runckel C, Chiu CY, Haggerty T, Parsonnet J, Ganem D, DeRisi JL.
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+ Virol J. 2009 Jun 18;6:82. doi: 10.1186/1743-422X-6-82.
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+ PMID: 19538752</description>
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+ </descriptions>
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+ </resource>
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+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
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+ <identifier identifierType="DOI">10.7272/Q62Z13FS</identifier>
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+ <creators>
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+ <creator>
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+ <creatorName>Weiner, Michael W.</creatorName>
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+ </creator>
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+ </creators>
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+ <titles>
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+ <title>Frontotemporal Lobar Degeneration (FTLD)</title>
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+ </titles>
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+ <publisher>University of California, San Francisco</publisher>
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+ <publicationYear>2012</publicationYear>
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+ <subjects>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Adult</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Human</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Magnetic Resonance Imaging</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Cognition</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Neuropsychological Test</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Aged</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Middle Aged</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Atrophy</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Pathology</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Physiopathology</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Brain</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Dementia</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Mental Disorders</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Frontotemporal Dementia</subject>
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+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Alzheimer's Disease</subject>
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+ </subjects>
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+ <contributors>
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+ <contributor contributorType="ResearchGroup">
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+ <contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
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+ </contributor>
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+ </contributors>
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+ <dates>
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+ <date dateType="Collected">2002-2009</date>
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+ </dates>
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+ <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
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+ <descriptions>
40
+ <description descriptionType="Abstract">This data set was acquired with the aim of determining the structural and chemical changes that occur in the brain as a result of frontotemporal lobar degeneration (FTLD). The data includes proton density, T1, and T2-weighted neuroimages from subjects suffering from FTLD and Alzheimer's Disease, as well as a population of matched controls.</description>
41
+ <description descriptionType="Methods">Data Acquisition Location: San Francisco VA Medical Center; Scanner Type: Siemens Vision 1.5T; Coronal T1 MPRAGE (orthogonal to long axis of hippocampus): TR=9ms, TE=4ms, TI=300ms, 1x1mm2, 1.5mm slice thickness; Coronal MPRAGE (orthogonal to PD, T2): TR=10ms, TE=7ms, TI=300ms, 1x1mm2, 1.4mm slice thickness; Axial double spin echo PD &amp; T2: TR=2500ms, TE=20/80ms, 1x1.25mm2, 3mm slice thickness.</description>
42
+ </descriptions>
43
+ </resource>
@@ -0,0 +1,25 @@
1
+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
2
+ <identifier identifierType="DOI"/>
3
+ <creators>
4
+ <creator><creatorName>Dr. David Wang</creatorName></creator>
5
+ </creators>
6
+ <titles>
7
+ <title>C. elegans RNA Sequence for viral discovery</title>
8
+ </titles>
9
+ <publisher>University of California, San Francisco</publisher>
10
+ <publicationYear>2014</publicationYear>
11
+ <subjects>
12
+ <subject>C. elegans</subject>
13
+ <subject>454 deep sequencing dataset</subject>
14
+ </subjects>
15
+ <contributors>
16
+ <contributor contributorType="ResearchGroup"><contributorName>UCSF</contributorName></contributor>
17
+ </contributors>
18
+ <resourceType resourceTypeGeneral="Dataset">Dataset</resourceType>
19
+ <descriptions>
20
+ <description descriptionType="Abstract">Nucleic acid from two nematode species, C. elegans JU1580 (isolated from a rotting apple in Orsay, France) and C. briggsae JU1264 (isolated from a snail on a rotting grape in Santeuil, France) were prepared and pyrosequenced on the Roche Titanium Genome Sequencer. Raw sequence reads were filtered for quality and repetitive sequences as described in &quot;Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses&quot; by F?©lix et al (http://www.ncbi.nlm.nih.gov/pubmed/21283608). Two novel members of the Nodaviridae viral family, Orsay nodavirus and Santeuil nodavirus, were discovered in the the 15933 and 20,787 reads, respectively. 1046 Orsay nodavirus reads were found in the C. elegans samples while 2492 Santeuil nodavirus reads were identified in in the C. briggsae sample. The data are provided in FASTA format.</description>
21
+ <description descriptionType="Methods">This is a 454 dataset corresponding to the raw reads from Felix et al., 2011</description>
22
+ <description descriptionType="SeriesInformation">Félix M-A, Ashe A, Piffaretti J, Wu G, Nuez I, et al. (2011) Natural and Experimental Infection of Caenorhabditis Nematodes by Novel Viruses Related to Nodaviruses. PLoS Biol 9: e1000586. doi:10.1371/journal.pbio.1000586. PMC3026760
23
+ </description>
24
+ </descriptions>
25
+ </resource>
@@ -0,0 +1,42 @@
1
+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
2
+ <identifier identifierType="DOI">10.7272/Q66Q1V54 </identifier>
3
+ <creators>
4
+ <creator>
5
+ <creatorName>Weiner, Michael W.</creatorName>
6
+ </creator>
7
+ </creators>
8
+ <titles>
9
+ <title>Gulf War Illness</title>
10
+ </titles>
11
+ <publisher>University of California, San Francisco</publisher>
12
+ <publicationYear>2012</publicationYear>
13
+ <subjects>
14
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Adult</subject>
15
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Human</subject>
16
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Magnetic Resonance Imaging</subject>
17
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Cognition</subject>
18
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Neuropsychological Test</subject>
19
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Gulf War</subject>
20
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Middle Aged</subject>
21
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Persian Gulf Syndrome</subject>
22
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Veterans</subject>
23
+ </subjects>
24
+ <contributors>
25
+ <contributor contributorType="ResearchGroup">
26
+ <contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
27
+ </contributor>
28
+ </contributors>
29
+ <dates>
30
+ <date dateType="Collected">2001-2009</date>
31
+ </dates>
32
+ <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
33
+ <relatedIdentifiers>
34
+ <relatedIdentifier relatedIdentifierType="PMID" relationType="References">20580739</relatedIdentifier>
35
+ <relatedIdentifier relatedIdentifierType="PMID" relationType="References">21882779</relatedIdentifier>
36
+ <relatedIdentifier relatedIdentifierType="PMID" relationType="References">21094937</relatedIdentifier>
37
+ </relatedIdentifiers>
38
+ <descriptions>
39
+ <description descriptionType="Abstract">Some veterans who served in the Gulf War subsequently complained of a wide variety of physical and neuro-psychological symptoms, termed Gulf War Illness (GWI). Several investigators have attributed these symptoms to stress. In contrast, Haley and coworkers reported clusters of symptoms into three primary syndromes and reported reductions of the neuronal marker N- Acetyl aspartate (NAA, a marker of neuron integrity and density) in the basal ganglia and pons of some GWI subjects. Based on this and other data they suggested that GWI has a neurological component. One limitation of previous studies is that post traumatic stress disorder (PTSD), depresssion, and alcoholism also cause structural and metabolic changes in the brain; the previous studies did not carefully control for these confounds. The primary goal of this project was to test the hypothesis that: subjects with GWI have metabolic and/or morphological changes in their brain, which are not accounted for by confounds such as post traumatic stress disorder (PTSD), alcohol abuse, and depression. A secondary goal was to determine: if these brain changes correlate with CNS signs and symptoms of GWI. This project studied 200 subjects with GWI and 200 Gulf War Veteran (GWV) controls drawn from Northern California and surrounding regions. GWI was defined by the same criteria used in previous VA cooperative studies. The extent of alcohol abuse and PTSD symptoms was measured. MRI/MRS, audiovestibular, neuro-psychological and other measurements were also made.</description>
40
+ <description descriptionType="Methods">Data Acquisition Location: San Francisco VA Medical Center; Scanner Type: Siemens Vision 1.5T; Coronal T1 MPRAGE: TR=9ms, TE=4ms, TI=300ms, 1x1mm2, 3mm slice thickness; Axial double spin echo PD &amp; T2: TR=2500ms, TE=20/80ms, 1x1mm2, 3mm slice thickness</description>
41
+ </descriptions>
42
+ </resource>
@@ -0,0 +1,63 @@
1
+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
2
+ <identifier identifierType="DOI">10.7272/Q67P8W9Z </identifier>
3
+ <creators>
4
+ <creator>
5
+ <creatorName>Zhang, Yu</creatorName>
6
+ </creator>
7
+ <creator>
8
+ <creatorName>Du, An-Tao</creatorName>
9
+ </creator>
10
+ <creator>
11
+ <creatorName>Hayasaka, Satoru</creatorName>
12
+ </creator>
13
+ <creator>
14
+ <creatorName>Jahng, Geon-ho</creatorName>
15
+ </creator>
16
+ <creator>
17
+ <creatorName>Hlavin, Jennifer</creatorName>
18
+ </creator>
19
+ <creator>
20
+ <creatorName>Zhan, Wang</creatorName>
21
+ </creator>
22
+ <creator>
23
+ <creatorName>Weiner, Michael W.</creatorName>
24
+ </creator>
25
+ <creator>
26
+ <creatorName>Schuff, Norbert</creatorName>
27
+ </creator>
28
+ <creator>
29
+ <creatorName>Memory and Aging Center</creatorName>
30
+ </creator>
31
+ </creators>
32
+ <titles>
33
+ <title>Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis.</title>
34
+ </titles>
35
+ <publisher>University of California, San Francisco</publisher>
36
+ <publicationYear>2012</publicationYear>
37
+ <subjects>
38
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Adult</subject>
39
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Human</subject>
40
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Magnetic Resonance Imaging</subject>
41
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Diffusion Magnetic Resonance Imaging</subject>
42
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Brain</subject>
43
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Aged</subject>
44
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Middle Aged</subject>
45
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Young Adult</subject>
46
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Anisotropy</subject>
47
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Reference Values</subject>
48
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Aging</subject>
49
+ </subjects>
50
+ <contributors>
51
+ <contributor contributorType="ResearchGroup">
52
+ <contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
53
+ </contributor>
54
+ </contributors>
55
+ <resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
56
+ <relatedIdentifiers>
57
+ <relatedIdentifier relatedIdentifierType="PMID" relationType="References">19036473</relatedIdentifier>
58
+ </relatedIdentifiers>
59
+ <descriptions>
60
+ <description descriptionType="Abstract">In diffusion tensor imaging (DTI), interpreting changes in terms of fractional anisotropy (FA) and mean diffusivity or axial (D(||)) and radial (D(?)) diffusivity can be ambiguous. The main objective of this study was to gain insight into the heterogeneity of age-related diffusion changes in human brain white matter by analyzing relationships between the diffusion measures in terms of concordance and discordance instead of evaluating them separately, which is difficult to interpret. Fifty-one cognitively normal subjects (22-79 years old) were studied with DTI at 4 Tesla. Age was associated with widespread concordant changes of decreased FA and increased MD but in some regions significant FA reductions occurred discordant to MD changes. Prominent age-related FA reductions were primarily related to greater radial (D(?)) than axial (D(||)) diffusivity changes, potentially reflecting processes of demyelination. In conclusion, concordant/discordant changes of DTI indices provide additional characterization of white matter alterations that accompany normal aging.</description>
61
+ <description descriptionType="Methods">The dataset available here consists of Fractional Anisotropy (FA), Mean Diffusivity (MD), Axial Diffusivity (I1), and Radial Diffusivity (Dra) images as well as subject-study-specific normalization images (B0, see methods in paper) in Analyze format. There are B0, FA, MD, I1, and Dra images for 51 subjects, and a spreadsheet describing each subject's handedness (right, left or ambidextrous), age (at time of scan), gender, ApoE alleles, and Mini-Mental State Exam score. Data Acquisition Location: San Francisco VA Medical Center; Scanner Type: Siemens Bruker 4T, equipped with a birdcage transmit and 8 channel receive coil. DTI was based on a dual spin-echo echo-planar imaging (EPI) sequence, augmented by parallel imaging acceleration (GRAPPA) by a factor 2 to reduce susceptibility distortions. Other imaging parameters were: TR/TE = 6000/77 ms; field of view 256 cm × 224 cm; 128 × 112 matrix size, yielding 2 mm × 2 mm in-plane resolution; 40 continuous slices, each 3 mm thick. A diffusion reference image (no diffusion gradient b = 0) and six diffusion-weighted images (b = 800 s/mm2 along 6 non-collinear directions) were acquired. Four DTI scans were acquired and averaged after motion correction to boost signal-to-noise.</description>
62
+ </descriptions>
63
+ </resource>
@@ -0,0 +1,24 @@
1
+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
2
+ <identifier identifierType="DOI"/>
3
+ <creators>
4
+ <creator><creatorName>Malone, Ruth E.</creatorName></creator>
5
+ <creator><creatorName>McDaniel, Patricia A.</creatorName></creator>
6
+ </creators>
7
+ <titles>
8
+ <title>Media coverage of nonsmoker only hiring policies</title>
9
+ </titles>
10
+ <publisher>University of California, San Francisco</publisher>
11
+ <publicationYear>2015</publicationYear>
12
+ <subjects>
13
+ <subject>Tobacco control</subject>
14
+ <subject>Media analysis</subject>
15
+ </subjects>
16
+ <contributors>
17
+ <contributor contributorType="ResearchGroup"><contributorName>UCSF</contributorName></contributor>
18
+ </contributors>
19
+ <resourceType resourceTypeGeneral="Dataset">Dataset</resourceType>
20
+ <descriptions>
21
+ <description descriptionType="Abstract">This SPSS dataset contains 1,159 records (from 1995-2013) representing the content of media items published in the US concerning employers who chose to hire only nonsmokers. The Excel spreadsheet contains a list of the titles, authors, publication sources, and publication dates of all the media items in the SPSS database.</description>
22
+ <description descriptionType="Methods">There are 71 variables in the SPSS dataset that cover the characteristics of each media item, as well as the content.</description>
23
+ </descriptions>
24
+ </resource>
@@ -0,0 +1,63 @@
1
+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
2
+ <identifier identifierType="DOI">10.7272/Q6BG2KWF </identifier>
3
+ <creators>
4
+ <creator>
5
+ <creatorName>Harper, Cynthia</creatorName>
6
+ </creator>
7
+ <creator>
8
+ <creatorName>Blanchard, Kelly</creatorName>
9
+ </creator>
10
+ <creator>
11
+ <creatorName>Chipato, Tsungai</creatorName>
12
+ </creator>
13
+ <creator>
14
+ <creatorName>Nhemachena, Taazadza</creatorName>
15
+ </creator>
16
+ <creator>
17
+ <creatorName>Ramjee, Gita</creatorName>
18
+ </creator>
19
+ <creator>
20
+ <creatorName>Blum, Maya</creatorName>
21
+ </creator>
22
+ </creators>
23
+ <titles>
24
+ <title>Provider counseling and provision of female condom in South Africa and Zimbabwe</title>
25
+ </titles>
26
+ <publisher>University of California, San Francisco</publisher>
27
+ <publicationYear>2012</publicationYear>
28
+ <subjects>
29
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">HIV</subject>
30
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Prevention</subject>
31
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Female condoms</subject>
32
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Health care providers</subject>
33
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Southern Africa</subject>
34
+ </subjects>
35
+ <contributors>
36
+ <contributor contributorType="ResearchGroup">
37
+ <contributor>UCSF Bixby Center for Global Reproductive Health</contributor>
38
+ </contributor>
39
+ <contributor contributorType="ResearchGroup">
40
+ <contributor>Ibis Reproductive Health</contributor>
41
+ </contributor>
42
+ <contributor contributorType="ResearchGroup">
43
+ <contributor>UZ-UCSF Collaborative Programme on Women's Health</contributor>
44
+ </contributor>
45
+ <contributor contributorType="ResearchGroup">
46
+ <contributor>South African Medical Research Council HIV Prevention Research Unit</contributor>
47
+ </contributor>
48
+ </contributors>
49
+ <dates>
50
+ <date dateType="Collected">2008-2009</date>
51
+ </dates>
52
+ <resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
53
+ <relatedIdentifiers>
54
+ <relatedIdentifier relatedIdentifierType="PMID" relationType="References">23512836</relatedIdentifier>
55
+ </relatedIdentifiers>
56
+ <rightsList>
57
+ <rights>Terms of Use for these data are outlined in the associated Data Use Agreement</rights>
58
+ </rightsList>
59
+ <descriptions>
60
+ <description descriptionType="Abstract">Objectives: Female condoms are the only female-initiated HIV and pregnancy prevention technology currently available. We examined female condom counseling and provision among providers in South Africa and Zimbabwe, high HIV-prevalence countries. Design: Cross-sectional study using a nationally-representative survey. Setting: All facilities that provide family planning or HIV/STI services in the two countries. Participants: National probability sample of 1,444 nurses and physicians who provide family planning or HIV/STI services. Primary and secondary outcome measures: Female condom practices with different female patients, including adolescents, married women, women using hormonal contraception, and by HIV status. Using multivariable logistic analysis, we measured variations in condom counseling by provider characteristics. Results: Most providers reported offering female condoms (88%), but perceived a need for novel female barrier methods for HIV/STI prevention (85%). By patient type, providers reported less frequent female condom counseling of adolescents (55%), women using hormonal contraception (65%), and married women (66%), compared to unmarried (74%) or HIV-positive women (82%). Multivariable results showed providers in South Africa were less likely to counsel women on female condoms than in Zimbabwe (OR=0.48, 95% CI: 0.35-0.68, p= 0.001). However, South African providers were more likely to counsel women on male condoms (OR=2.39, 95% CI: 1.57-3.65, p= 0.001). Nurses counseled patients on female condoms more frequently than physicians (OR=5.41, 95% CI: 3.26-8.98, p= 0.001). HIV training, family planning training, provider location (urban vs. rural), and facility type (hospital vs. clinic) were not associated with greater condom counseling. Conclusions: Female condoms were integrated into provider counseling and care, although providers reported a need for new female-initiated multipurpose prevention technologies, suggesting female condoms do not meet all patient/provider needs or are not adequately well-known or accessible. Providers should be included in HIV training efforts to raise awareness of new and existing products, and encouraged to educate all women.</description>
61
+ <description descriptionType="Methods">Stata dataset</description>
62
+ </descriptions>
63
+ </resource>
@@ -0,0 +1,43 @@
1
+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
2
+ <identifier identifierType="DOI"/>
3
+ <creators>
4
+ <creator>
5
+ <creatorName>Simpson, Paul C.</creatorName>
6
+ </creator>
7
+ </creators>
8
+ <titles>
9
+ <title>Alpha-1A Adrenergic Receptor in Rabbit Heart</title>
10
+ </titles>
11
+ <publisher>UC San Francisco</publisher>
12
+ <publicationYear>2016</publicationYear>
13
+ <subjects>
14
+ <subject>adrenergic receptor, alpha-1-A</subject>
15
+ <subject>rabbit</subject>
16
+ <subject>heart</subject>
17
+ </subjects>
18
+ <contributors>
19
+ <contributor contributorType="DataManager">
20
+ <contributorName>Simpson, Paul</contributorName>
21
+ </contributor>
22
+ <contributor contributorType="Funder">
23
+ <contributorName>Dept of Veterans Affaits, National Institutes of Health, Western States Affiliate of the American Heart Association</contributorName>
24
+ </contributor>
25
+ </contributors>
26
+ <relatedIdentifiers/>
27
+ <resourceType resourceTypeGeneral="Dataset">Dataset</resourceType>
28
+ <sizes>
29
+ <size>110724</size>
30
+ </sizes>
31
+ <rightsList>
32
+ <rights rightsURI="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International (CC-BY 4.0)</rights>
33
+ </rightsList>
34
+ <descriptions>
35
+ <description descriptionType="Abstract">The alpha-1A-adrenergic receptor (AR) subtype is associated with cardioprotective signaling in the mouse and human heart. The rabbit is useful for cardiac disease modeling, but data on the alpha-1A in the rabbit heart are limited. Our objective was to test for expression and function of the alpha-1A in rabbit heart. By quantitative real-time reverse transcription PCR (qPCR) on mRNA from left ventricular myocardium of adult male New Zealand White rabbits, the alpha-1B was 99% of total alpha-1-AR mRNA, with &lt;1% alpha-1A and alpha-1D, whereas alpha-1A mRNA was over 50% of total in brain and liver. Saturation radioligand binding identified ~4 fmol total alpha-1-ARs per mg myocardial protein, with 17% alpha-1A by competition with the selective antagonist 5-methylurapidil. The alpha-1D was not detected by competition with BMY-7378, indicating that 83% of alpha-1-ARs were alpha-1B. In isolated left ventricle and right ventricle, the selective alpha-1A agonist A61603 stimulated a negative inotropic effect, versus a positive inotropic effect with the nonselective alpha-1-agonist phenylephrine and the beta-agonist isoproterenol. Blood pressure assay in conscious rabbits using an indwelling aortic telemeter showed that A61603 by bolus intravenous dosing increased mean arterial pressure by 20 mm Hg at 0.14 μg/kg, 10-fold lower than norepinephrine, and chronic A61603 infusion by iPRECIO programmable micro Infusion pump did not increase BP at 22 μg/kg/d. A myocardial slice model useful in human myocardium and an anthracycline cardiotoxicity model useful in mouse were both problematic in rabbit. We conclude that alpha-1A mRNA is very low in rabbit heart, but the receptor is present by binding and mediates a negative inotropic response. Expression and function of the alpha-1A in rabbit heart differ from mouse and human, but the vasopressor response is similar to mouse.</description>
36
+ <description descriptionType="Methods">Details in Plos One paper
37
+ Fig 1. qPCR
38
+ Fig 2. saturation and competition radioligand binding
39
+ FIG 3. Contraction in isolated heart muscle
40
+ FIG 4. Telemetry blood pressure and heart rate in vivo</description>
41
+ <description descriptionType="Other">NIH RO1 HL31113, VA BX001970</description>
42
+ </descriptions>
43
+ </resource>
@@ -0,0 +1,63 @@
1
+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
2
+ <identifier identifierType="DOI">10.7272/Q6CC0XMH</identifier>
3
+ <creators>
4
+ <creator>
5
+ <creatorName>Zhang, Yu</creatorName>
6
+ </creator>
7
+ <creator>
8
+ <creatorName>Schuff, Norbert</creatorName>
9
+ </creator>
10
+ <creator>
11
+ <creatorName>Du, An-Tao</creatorName>
12
+ </creator>
13
+ <creator>
14
+ <creatorName>Rosen, Howard J.</creatorName>
15
+ </creator>
16
+ <creator>
17
+ <creatorName>Kramer, Joel H.</creatorName>
18
+ </creator>
19
+ <creator>
20
+ <creatorName>Gorno-Tempini, Maria Luisa</creatorName>
21
+ </creator>
22
+ <creator>
23
+ <creatorName>Miller, Bruce L.</creatorName>
24
+ </creator>
25
+ <creator>
26
+ <creatorName>Weiner, Michael W.</creatorName>
27
+ </creator>
28
+ <creator>
29
+ <creatorName>Memory and Aging Center</creatorName>
30
+ </creator>
31
+ </creators>
32
+ <titles>
33
+ <title>White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI</title>
34
+ </titles>
35
+ <publisher>University of California, San Francisco</publisher>
36
+ <publicationYear>2012</publicationYear>
37
+ <subjects>
38
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Adult</subject>
39
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Human</subject>
40
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Magnetic Resonance Imaging</subject>
41
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Diffusion Magnetic Resonance Imaging</subject>
42
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Brain</subject>
43
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Aged</subject>
44
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Middle Aged</subject>
45
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Alzheimer's Disease</subject>
46
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Cross-sectional Studies</subject>
47
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Dementia</subject>
48
+ <subject schemeURI="http://www.nlm.nih.gov/mesh/" subjectScheme="MeSH">Differential Diagnosis</subject>
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+ </subjects>
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+ <contributors>
51
+ <contributor contributorType="ResearchGroup">
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+ <contributorName>UCSF Center for Imaging of Neurodegenerative Diseases</contributorName>
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+ </contributor>
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+ </contributors>
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+ <resourceType resourceTypeGeneral="Dataset">application/octet-stream</resourceType>
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+ <relatedIdentifiers>
57
+ <relatedIdentifier relatedIdentifierType="PMID" relationType="References">19439421</relatedIdentifier>
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+ </relatedIdentifiers>
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+ <descriptions>
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+ <description descriptionType="Abstract">Frontotemporal dementia (FTD) and Alzheimer's disease are sometimes difficult to differentiate clinically because of overlapping symptoms. Using diffusion tensor imaging (DTI) measurements of fractional anisotropy (FA) can be useful in distinguishing the different patterns of white matter degradation between the two dementias. In this study, we performed MRI scans in a 4 Tesla MRI machine including T1-weighted structural images and diffusion tensor images in 18 patients with FTD, 18 patients with Alzheimer's disease and 19 cognitively normal (CN) controls. FA was measured selectively in specific fibre tracts (including corpus callosum, cingulum, uncinate and corticospinal tracts) as well as globally in a voxel-by-voxel analysis. Patients with FTD were associated with reductions of FA in frontal and temporal regions including the anterior corpus callosum (P &lt; 0.001), bilateral anterior (left P &lt; 0.001; right P = 0.005), descending (left P &lt; 0.001; right P = 0.003) cingulum tracts, and uncinate tracts (left P &lt; 0.001; right P = 0.005), compared to controls. Patients with Alzheimer's disease were associated with reductions of FA in parietal, temporal and frontal regions including the left anterior (P = 0.003) and posterior (P = 0.002) cingulum tracts, bilateral descending cingulum tracts (P &lt; 0.001) and left uncinate tracts (P &lt; 0.001) compared to controls. When compared with Alzheimer's disease, FTD was associated with greater reductions of FA in frontal brain regions, whereas no region in Alzheimer's disease showed greater reductions of FA when compared to FTD. In conclusion, the regional patterns of anisotropy reduction in FTD and Alzheimer's disease compared to controls suggest a characteristic distribution of white matter degradation in each disease. Moreover, the white matter degradation seems to be more prominent in FTD than in Alzheimer's disease. Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease.</description>
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+ <description descriptionType="Methods">The dataset available here consists of Fractional Anisotropy (FA) and Mean Diffusivity (MD) images in Analyze format. There are FA &amp; MD images for 55 subjects (some subjects have two timepoints, as indicated by a -1 or -2 following subject ID in the filename, please disregard timepoint 2 at this time), and a spreadsheet describing each subject’s age (at time of scan), gender, diagnosis (Normal Control, Alzheimer’s Dissease, or Frontotemporal Dementia), ApoE alleles, and Mini-Mental State Exam score. Data Acquisition Location: San Francisco VA Medical Center; Scanner Type: Siemens Bruker 4T, equipped with a birdcage transmit and eight channel receive coil. DTI was based on a dual spin-echo echo-planar imaging (EPI) sequence supplemented with parallel imaging acceleration (GRAPPA) with a factor 2 to reduce susceptibility distortions. Other imaging parameters were: TR/TE = 6000/77 ms; field of view 256 × 224 cm; 128 × 112 matrix size, yielding 2 × 2 mm2 in-plane resolution; 40 continuous 3 mm slices. A reference image (no diffusion gradient b = 0) and six diffusion-weighted images (b = 800 s/mm2 along six non-collinear directions) were acquired. Four DTI scans were acquired and averaged after motion correction to boost signal-to-noise.</description>
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+ </descriptions>
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+ </resource>
@@ -0,0 +1,26 @@
1
+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
2
+ <identifier identifierType="DOI"/>
3
+ <creators>
4
+ <creator><creatorName>Chang, Yishin</creatorName></creator>
5
+ <creator><creatorName>Mukherjee, Pratik</creatorName></creator>
6
+ </creators>
7
+ <titles>
8
+ <title>NODDI-PLOS-ONE-Chang et al 2015</title>
9
+ </titles>
10
+ <publisher>University of California, San Francisco</publisher>
11
+ <publicationYear>2015</publicationYear>
12
+ <subjects>
13
+ <subject>DTI</subject>
14
+ <subject>NODDI</subject>
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+ <subject>Human brain maturation</subject>
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+ <subject>White matter</subject>
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+ </subjects>
18
+ <contributors>
19
+ <contributor contributorType="ResearchGroup"><contributorName>UCSF</contributorName></contributor>
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+ </contributors>
21
+ <resourceType resourceTypeGeneral="Dataset">Dataset</resourceType>
22
+ <descriptions>
23
+ <description descriptionType="Abstract">Diffusion tensor imaging (DTI) studies of human brain development have consistently shown widespread, but nonlinearly increasing white matter anisotropy through childhood, adolescence, and into adulthood. However, despite its sensitivity to changes in tissue microstructure, DTI lacks the specificity to disentangle distinct microstructural features of white and gray matter. Neurite orientation dispersion and density imaging (NODDI) is a recently proposed multi-compartment biophysical model of brain microstructure that can estimate non-collinear properties of white matter, such as neurite orientation dispersion (OD) and neurite density (ND). In this study, we apply NODDI to 67 healthy controls aged 7-63 years to investigate changes of OD and ND with brain maturation, with comparison to standard DTI metrics. Using both region-of-interest and voxel-wise analyses, we find that ND exhibits striking increases over the studied age range following a logarithmic growth pattern, while OD rises following an exponential growth pattern. This novel finding is consistent with well-established age-related changes of FA over the lifespan that show growth during childhood and adolescence, plateau during early adulthood, and accelerating decay after the fourth decade of life. Our results suggest that the rise of FA during the first two decades of life is dominated by increasing ND, while the fall in FA after the fourth decade is driven by the exponential rise of OD that overcomes the slower increases of ND. Using partial least squares regression, we further demonstrate that NODDI better predicts chronological age than DTI. Finally, we show excellent test-retest reliability of NODDI metrics, with coefficients of variation below 5% in all measured regions of interest. Our results support the conclusion that NODDI reveals biologically specific characteristics of brain development that are more closely linked to the microstructural features of white matter than are the empirical metrics provided by DTI.</description>
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+ <description descriptionType="Methods">NODDI</description>
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+ </descriptions>
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+ </resource>
@@ -0,0 +1,46 @@
1
+ <?xml version="1.0" encoding="utf-8"?><resource xmlns="http://datacite.org/schema/kernel-3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd">
2
+ <identifier identifierType="DOI"/>
3
+ <creators>
4
+ <creator>
5
+ <creatorName>UCSF Library</creatorName>
6
+ </creator>
7
+ </creators>
8
+ <titles>
9
+ <title>UCSF LibQUAL Library Survey Results 2015</title>
10
+ </titles>
11
+ <publisher>UC San Francisco</publisher>
12
+ <publicationYear>2016</publicationYear>
13
+ <subjects>
14
+ <subject>Library</subject>
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+ <subject>Survey</subject>
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+ <subject>Customer Satisfaction</subject>
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+ <subject>User Experience</subject>
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+ </subjects>
19
+ <contributors>
20
+ <contributor contributorType="DataManager">
21
+ <contributorName>Deardorff, Ariel</contributorName>
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+ </contributor>
23
+ </contributors>
24
+ <relatedIdentifiers/>
25
+ <resourceType resourceTypeGeneral="Collection">Collection</resourceType>
26
+ <sizes>
27
+ <size>2165128</size>
28
+ </sizes>
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+ <rightsList>
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+ <rights rightsURI="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International (CC-BY 4.0)</rights>
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+ </rightsList>
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+ <descriptions>
33
+ <description descriptionType="Abstract">These datasets contain the Mission Bay and Parnassus responses to the 2015 UCSF Library Survey. The Library Survey asks about three distinct aspects of the library: Affect of Service (people), Information Control (resources) and Library as Place (spaces). For each question, survey respondents are asked to select the minimum service level they would expect from the library, the level of service they desire, and where they think the library is currently performing. Using these three measures provides valuable information about how the Library’s users think it is performing relative to their needs.
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+
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+ The survey was produced by LibQUAL+® for UCSF Library. LibQUAL+® is a suite of services that libraries use to solicit, track, understand, and act upon users’ opinions of service quality. These services are offered to the library community by the Association of Research Libraries (ARL). For more information, visit http://libqual.org
36
+ </description>
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+ <description descriptionType="Methods">Data Collection:
38
+ The Library survey, which was administered from Nov 2-29 2015, was sent to all UCSF students, faculty, and staff via UCSF campus email lists. The complete survey instrument consists of demographic questions, 22 survey questions and a comment box. To reduce the time commitment, UCSF respondents were given a random subset of the 22 survey questions.
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+
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+ Analysis:
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+ The quantitative dataset, consisting of survey respondents rating of minimum, desired, and perceived level of service, was cleaned and arranged into a format more suitable for analysis.
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+
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+ The qualitative dataset, consisting of the comments portion of the survey, was coded by a group of library staff in order to highlight the different topics discussed. Because a comment often touched on many different topics each comment could receive multiple codes. Once the comments had all been coded the spreadsheet was transformed into a format more suitable for filtering and analysis.
44
+ </description>
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+ </descriptions>
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+ </resource>