MARQ 0.0.1

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  1. data/LICENSE +20 -0
  2. data/R/CustomDS.R +80 -0
  3. data/R/GEO.R +249 -0
  4. data/R/MA.R +359 -0
  5. data/README.rdoc +29 -0
  6. data/bin/marq_config +170 -0
  7. data/install_scripts/CustomDS/Rakefile +223 -0
  8. data/install_scripts/GEO/Rakefile +258 -0
  9. data/install_scripts/GEO/platforms/GPL100.yaml +7 -0
  10. data/install_scripts/GEO/platforms/GPL1002.yaml +7 -0
  11. data/install_scripts/GEO/platforms/GPL1007.yaml +7 -0
  12. data/install_scripts/GEO/platforms/GPL101.yaml +7 -0
  13. data/install_scripts/GEO/platforms/GPL1010.yaml +7 -0
  14. data/install_scripts/GEO/platforms/GPL1073.yaml +7 -0
  15. data/install_scripts/GEO/platforms/GPL1074.yaml +4 -0
  16. data/install_scripts/GEO/platforms/GPL1090.yaml +7 -0
  17. data/install_scripts/GEO/platforms/GPL1104.yaml +7 -0
  18. data/install_scripts/GEO/platforms/GPL118.yaml +7 -0
  19. data/install_scripts/GEO/platforms/GPL1205.yaml +4 -0
  20. data/install_scripts/GEO/platforms/GPL1211.yaml +7 -0
  21. data/install_scripts/GEO/platforms/GPL1213.yaml +7 -0
  22. data/install_scripts/GEO/platforms/GPL1219.yaml +4 -0
  23. data/install_scripts/GEO/platforms/GPL1223.yaml +7 -0
  24. data/install_scripts/GEO/platforms/GPL1226.yaml +7 -0
  25. data/install_scripts/GEO/platforms/GPL1229.yaml +7 -0
  26. data/install_scripts/GEO/platforms/GPL1230.yaml +7 -0
  27. data/install_scripts/GEO/platforms/GPL1231.yaml +7 -0
  28. data/install_scripts/GEO/platforms/GPL1232.yaml +7 -0
  29. data/install_scripts/GEO/platforms/GPL1260.yaml +4 -0
  30. data/install_scripts/GEO/platforms/GPL1261.yaml +4 -0
  31. data/install_scripts/GEO/platforms/GPL127.yaml +4 -0
  32. data/install_scripts/GEO/platforms/GPL128.yaml +7 -0
  33. data/install_scripts/GEO/platforms/GPL1290.yaml +7 -0
  34. data/install_scripts/GEO/platforms/GPL1292.yaml +7 -0
  35. data/install_scripts/GEO/platforms/GPL1293.yaml +7 -0
  36. data/install_scripts/GEO/platforms/GPL1294.yaml +7 -0
  37. data/install_scripts/GEO/platforms/GPL1295.yaml +7 -0
  38. data/install_scripts/GEO/platforms/GPL13.yaml +4 -0
  39. data/install_scripts/GEO/platforms/GPL1310.yaml +7 -0
  40. data/install_scripts/GEO/platforms/GPL1313.yaml +7 -0
  41. data/install_scripts/GEO/platforms/GPL1323.yaml +7 -0
  42. data/install_scripts/GEO/platforms/GPL1331.yaml +7 -0
  43. data/install_scripts/GEO/platforms/GPL1352.yaml +4 -0
  44. data/install_scripts/GEO/platforms/GPL1355.yaml +4 -0
  45. data/install_scripts/GEO/platforms/GPL1382.yaml +7 -0
  46. data/install_scripts/GEO/platforms/GPL1387.yaml +7 -0
  47. data/install_scripts/GEO/platforms/GPL1397.yaml +4 -0
  48. data/install_scripts/GEO/platforms/GPL14.yaml +7 -0
  49. data/install_scripts/GEO/platforms/GPL1412.yaml +7 -0
  50. data/install_scripts/GEO/platforms/GPL1415.yaml +7 -0
  51. data/install_scripts/GEO/platforms/GPL1420.yaml +7 -0
  52. data/install_scripts/GEO/platforms/GPL144.yaml +7 -0
  53. data/install_scripts/GEO/platforms/GPL1449.yaml +7 -0
  54. data/install_scripts/GEO/platforms/GPL1458.yaml +7 -0
  55. data/install_scripts/GEO/platforms/GPL1523.yaml +7 -0
  56. data/install_scripts/GEO/platforms/GPL1524.yaml +7 -0
  57. data/install_scripts/GEO/platforms/GPL1528.yaml +7 -0
  58. data/install_scripts/GEO/platforms/GPL153.yaml +7 -0
  59. data/install_scripts/GEO/platforms/GPL1530.yaml +7 -0
  60. data/install_scripts/GEO/platforms/GPL1535.yaml +4 -0
  61. data/install_scripts/GEO/platforms/GPL155.yaml +7 -0
  62. data/install_scripts/GEO/platforms/GPL163.yaml +7 -0
  63. data/install_scripts/GEO/platforms/GPL168.yaml +7 -0
  64. data/install_scripts/GEO/platforms/GPL169.yaml +7 -0
  65. data/install_scripts/GEO/platforms/GPL1704.yaml +4 -0
  66. data/install_scripts/GEO/platforms/GPL1708.yaml +7 -0
  67. data/install_scripts/GEO/platforms/GPL1739.yaml +7 -0
  68. data/install_scripts/GEO/platforms/GPL1740.yaml +4 -0
  69. data/install_scripts/GEO/platforms/GPL1749.yaml +7 -0
  70. data/install_scripts/GEO/platforms/GPL177.yaml +7 -0
  71. data/install_scripts/GEO/platforms/GPL1790.yaml +7 -0
  72. data/install_scripts/GEO/platforms/GPL1792.yaml +7 -0
  73. data/install_scripts/GEO/platforms/GPL181.yaml +7 -0
  74. data/install_scripts/GEO/platforms/GPL1818.yaml +7 -0
  75. data/install_scripts/GEO/platforms/GPL1820.yaml +4 -0
  76. data/install_scripts/GEO/platforms/GPL1823.yaml +7 -0
  77. data/install_scripts/GEO/platforms/GPL1826.yaml +7 -0
  78. data/install_scripts/GEO/platforms/GPL183.yaml +7 -0
  79. data/install_scripts/GEO/platforms/GPL1831.yaml +7 -0
  80. data/install_scripts/GEO/platforms/GPL1833.yaml +7 -0
  81. data/install_scripts/GEO/platforms/GPL1872.yaml +4 -0
  82. data/install_scripts/GEO/platforms/GPL1911.yaml +7 -0
  83. data/install_scripts/GEO/platforms/GPL1914.yaml +4 -0
  84. data/install_scripts/GEO/platforms/GPL1928.yaml +7 -0
  85. data/install_scripts/GEO/platforms/GPL1942.yaml +7 -0
  86. data/install_scripts/GEO/platforms/GPL1945.yaml +7 -0
  87. data/install_scripts/GEO/platforms/GPL1964.yaml +7 -0
  88. data/install_scripts/GEO/platforms/GPL198.yaml +4 -0
  89. data/install_scripts/GEO/platforms/GPL1981.yaml +4 -0
  90. data/install_scripts/GEO/platforms/GPL200.yaml +7 -0
  91. data/install_scripts/GEO/platforms/GPL2006.yaml +7 -0
  92. data/install_scripts/GEO/platforms/GPL201.yaml +4 -0
  93. data/install_scripts/GEO/platforms/GPL2011.yaml +7 -0
  94. data/install_scripts/GEO/platforms/GPL2026.yaml +7 -0
  95. data/install_scripts/GEO/platforms/GPL205.yaml +7 -0
  96. data/install_scripts/GEO/platforms/GPL207.yaml +7 -0
  97. data/install_scripts/GEO/platforms/GPL2136.yaml +7 -0
  98. data/install_scripts/GEO/platforms/GPL220.yaml +7 -0
  99. data/install_scripts/GEO/platforms/GPL226.yaml +7 -0
  100. data/install_scripts/GEO/platforms/GPL24.yaml +4 -0
  101. data/install_scripts/GEO/platforms/GPL246.yaml +4 -0
  102. data/install_scripts/GEO/platforms/GPL247.yaml +7 -0
  103. data/install_scripts/GEO/platforms/GPL2507.yaml +4 -0
  104. data/install_scripts/GEO/platforms/GPL2529.yaml +4 -0
  105. data/install_scripts/GEO/platforms/GPL2531.yaml +7 -0
  106. data/install_scripts/GEO/platforms/GPL254.yaml +7 -0
  107. data/install_scripts/GEO/platforms/GPL2569.yaml +7 -0
  108. data/install_scripts/GEO/platforms/GPL257.yaml +7 -0
  109. data/install_scripts/GEO/platforms/GPL2598.yaml +7 -0
  110. data/install_scripts/GEO/platforms/GPL260.yaml +7 -0
  111. data/install_scripts/GEO/platforms/GPL2614.yaml +4 -0
  112. data/install_scripts/GEO/platforms/GPL2622.yaml +7 -0
  113. data/install_scripts/GEO/platforms/GPL2623.yaml +7 -0
  114. data/install_scripts/GEO/platforms/GPL2660.yaml +7 -0
  115. data/install_scripts/GEO/platforms/GPL2670.yaml +7 -0
  116. data/install_scripts/GEO/platforms/GPL2677.yaml +7 -0
  117. data/install_scripts/GEO/platforms/GPL2700.yaml +4 -0
  118. data/install_scripts/GEO/platforms/GPL2721.yaml +7 -0
  119. data/install_scripts/GEO/platforms/GPL2727.yaml +7 -0
  120. data/install_scripts/GEO/platforms/GPL273.yaml +7 -0
  121. data/install_scripts/GEO/platforms/GPL2763.yaml +7 -0
  122. data/install_scripts/GEO/platforms/GPL2824.yaml +7 -0
  123. data/install_scripts/GEO/platforms/GPL284.yaml +7 -0
  124. data/install_scripts/GEO/platforms/GPL287.yaml +4 -0
  125. data/install_scripts/GEO/platforms/GPL2872.yaml +7 -0
  126. data/install_scripts/GEO/platforms/GPL288.yaml +4 -0
  127. data/install_scripts/GEO/platforms/GPL2883.yaml +7 -0
  128. data/install_scripts/GEO/platforms/GPL289.yaml +4 -0
  129. data/install_scripts/GEO/platforms/GPL2895.yaml +4 -0
  130. data/install_scripts/GEO/platforms/GPL2897.yaml +7 -0
  131. data/install_scripts/GEO/platforms/GPL2902.yaml +7 -0
  132. data/install_scripts/GEO/platforms/GPL2987.yaml +4 -0
  133. data/install_scripts/GEO/platforms/GPL2995.yaml +7 -0
  134. data/install_scripts/GEO/platforms/GPL3039.yaml +4 -0
  135. data/install_scripts/GEO/platforms/GPL3050.yaml +7 -0
  136. data/install_scripts/GEO/platforms/GPL3084.yaml +7 -0
  137. data/install_scripts/GEO/platforms/GPL3113.yaml +7 -0
  138. data/install_scripts/GEO/platforms/GPL317.yaml +7 -0
  139. data/install_scripts/GEO/platforms/GPL319.yaml +7 -0
  140. data/install_scripts/GEO/platforms/GPL32.yaml +4 -0
  141. data/install_scripts/GEO/platforms/GPL3222.yaml +7 -0
  142. data/install_scripts/GEO/platforms/GPL3295.yaml +7 -0
  143. data/install_scripts/GEO/platforms/GPL3305.yaml +4 -0
  144. data/install_scripts/GEO/platforms/GPL3306.yaml +7 -0
  145. data/install_scripts/GEO/platforms/GPL3307.yaml +7 -0
  146. data/install_scripts/GEO/platforms/GPL333.yaml +4 -0
  147. data/install_scripts/GEO/platforms/GPL3341.yaml +7 -0
  148. data/install_scripts/GEO/platforms/GPL3349.yaml +7 -0
  149. data/install_scripts/GEO/platforms/GPL339.yaml +4 -0
  150. data/install_scripts/GEO/platforms/GPL340.yaml +4 -0
  151. data/install_scripts/GEO/platforms/GPL3408.yaml +7 -0
  152. data/install_scripts/GEO/platforms/GPL341.yaml +4 -0
  153. data/install_scripts/GEO/platforms/GPL3415.yaml +4 -0
  154. data/install_scripts/GEO/platforms/GPL3423.yaml +7 -0
  155. data/install_scripts/GEO/platforms/GPL3440.yaml +7 -0
  156. data/install_scripts/GEO/platforms/GPL3457.yaml +4 -0
  157. data/install_scripts/GEO/platforms/GPL3504.yaml +4 -0
  158. data/install_scripts/GEO/platforms/GPL3506.yaml +4 -0
  159. data/install_scripts/GEO/platforms/GPL355.yaml +7 -0
  160. data/install_scripts/GEO/platforms/GPL3558.yaml +7 -0
  161. data/install_scripts/GEO/platforms/GPL3607.yaml +7 -0
  162. data/install_scripts/GEO/platforms/GPL368.yaml +4 -0
  163. data/install_scripts/GEO/platforms/GPL3695.yaml +7 -0
  164. data/install_scripts/GEO/platforms/GPL371.yaml +7 -0
  165. data/install_scripts/GEO/platforms/GPL3834.yaml +4 -0
  166. data/install_scripts/GEO/platforms/GPL4006.yaml +7 -0
  167. data/install_scripts/GEO/platforms/GPL4055.yaml +7 -0
  168. data/install_scripts/GEO/platforms/GPL409.yaml +7 -0
  169. data/install_scripts/GEO/platforms/GPL4191.yaml +7 -0
  170. data/install_scripts/GEO/platforms/GPL4226.yaml +7 -0
  171. data/install_scripts/GEO/platforms/GPL4371.yaml +7 -0
  172. data/install_scripts/GEO/platforms/GPL4567.yaml +4 -0
  173. data/install_scripts/GEO/platforms/GPL4685.yaml +4 -0
  174. data/install_scripts/GEO/platforms/GPL483.yaml +7 -0
  175. data/install_scripts/GEO/platforms/GPL49.yaml +7 -0
  176. data/install_scripts/GEO/platforms/GPL50.yaml +7 -0
  177. data/install_scripts/GEO/platforms/GPL500.yaml +7 -0
  178. data/install_scripts/GEO/platforms/GPL507.yaml +4 -0
  179. data/install_scripts/GEO/platforms/GPL51.yaml +7 -0
  180. data/install_scripts/GEO/platforms/GPL513.yaml +7 -0
  181. data/install_scripts/GEO/platforms/GPL519.yaml +7 -0
  182. data/install_scripts/GEO/platforms/GPL52.yaml +7 -0
  183. data/install_scripts/GEO/platforms/GPL529.yaml +7 -0
  184. data/install_scripts/GEO/platforms/GPL53.yaml +7 -0
  185. data/install_scripts/GEO/platforms/GPL5356.yaml +7 -0
  186. data/install_scripts/GEO/platforms/GPL538.yaml +7 -0
  187. data/install_scripts/GEO/platforms/GPL54.yaml +7 -0
  188. data/install_scripts/GEO/platforms/GPL543.yaml +7 -0
  189. data/install_scripts/GEO/platforms/GPL544.yaml +7 -0
  190. data/install_scripts/GEO/platforms/GPL545.yaml +7 -0
  191. data/install_scripts/GEO/platforms/GPL546.yaml +7 -0
  192. data/install_scripts/GEO/platforms/GPL547.yaml +7 -0
  193. data/install_scripts/GEO/platforms/GPL549.yaml +7 -0
  194. data/install_scripts/GEO/platforms/GPL550.yaml +4 -0
  195. data/install_scripts/GEO/platforms/GPL56.yaml +7 -0
  196. data/install_scripts/GEO/platforms/GPL560.yaml +4 -0
  197. data/install_scripts/GEO/platforms/GPL564.yaml +7 -0
  198. data/install_scripts/GEO/platforms/GPL57.yaml +7 -0
  199. data/install_scripts/GEO/platforms/GPL570.yaml +4 -0
  200. data/install_scripts/GEO/platforms/GPL571.yaml +4 -0
  201. data/install_scripts/GEO/platforms/GPL576.yaml +7 -0
  202. data/install_scripts/GEO/platforms/GPL58.yaml +7 -0
  203. data/install_scripts/GEO/platforms/GPL5823.yaml +4 -0
  204. data/install_scripts/GEO/platforms/GPL59.yaml +7 -0
  205. data/install_scripts/GEO/platforms/GPL5915.yaml +4 -0
  206. data/install_scripts/GEO/platforms/GPL5947.yaml +7 -0
  207. data/install_scripts/GEO/platforms/GPL61.yaml +7 -0
  208. data/install_scripts/GEO/platforms/GPL64.yaml +7 -0
  209. data/install_scripts/GEO/platforms/GPL6419.yaml +7 -0
  210. data/install_scripts/GEO/platforms/GPL6424.yaml +7 -0
  211. data/install_scripts/GEO/platforms/GPL65.yaml +7 -0
  212. data/install_scripts/GEO/platforms/GPL6574.yaml +4 -0
  213. data/install_scripts/GEO/platforms/GPL6649.yaml +4 -0
  214. data/install_scripts/GEO/platforms/GPL67.yaml +7 -0
  215. data/install_scripts/GEO/platforms/GPL6720.yaml +7 -0
  216. data/install_scripts/GEO/platforms/GPL7054.yaml +4 -0
  217. data/install_scripts/GEO/platforms/GPL737.yaml +7 -0
  218. data/install_scripts/GEO/platforms/GPL738.yaml +7 -0
  219. data/install_scripts/GEO/platforms/GPL74.yaml +4 -0
  220. data/install_scripts/GEO/platforms/GPL75.yaml +4 -0
  221. data/install_scripts/GEO/platforms/GPL76.yaml +4 -0
  222. data/install_scripts/GEO/platforms/GPL764.yaml +7 -0
  223. data/install_scripts/GEO/platforms/GPL772.yaml +7 -0
  224. data/install_scripts/GEO/platforms/GPL782.yaml +7 -0
  225. data/install_scripts/GEO/platforms/GPL783.yaml +7 -0
  226. data/install_scripts/GEO/platforms/GPL784.yaml +7 -0
  227. data/install_scripts/GEO/platforms/GPL80.yaml +4 -0
  228. data/install_scripts/GEO/platforms/GPL81.yaml +4 -0
  229. data/install_scripts/GEO/platforms/GPL82.yaml +4 -0
  230. data/install_scripts/GEO/platforms/GPL83.yaml +4 -0
  231. data/install_scripts/GEO/platforms/GPL85.yaml +4 -0
  232. data/install_scripts/GEO/platforms/GPL86.yaml +4 -0
  233. data/install_scripts/GEO/platforms/GPL87.yaml +4 -0
  234. data/install_scripts/GEO/platforms/GPL870.yaml +7 -0
  235. data/install_scripts/GEO/platforms/GPL875.yaml +7 -0
  236. data/install_scripts/GEO/platforms/GPL884.yaml +7 -0
  237. data/install_scripts/GEO/platforms/GPL887.yaml +7 -0
  238. data/install_scripts/GEO/platforms/GPL89.yaml +4 -0
  239. data/install_scripts/GEO/platforms/GPL890.yaml +7 -0
  240. data/install_scripts/GEO/platforms/GPL891.yaml +7 -0
  241. data/install_scripts/GEO/platforms/GPL90.yaml +7 -0
  242. data/install_scripts/GEO/platforms/GPL91.yaml +4 -0
  243. data/install_scripts/GEO/platforms/GPL92.yaml +4 -0
  244. data/install_scripts/GEO/platforms/GPL920.yaml +7 -0
  245. data/install_scripts/GEO/platforms/GPL922.yaml +7 -0
  246. data/install_scripts/GEO/platforms/GPL924.yaml +7 -0
  247. data/install_scripts/GEO/platforms/GPL93.yaml +4 -0
  248. data/install_scripts/GEO/platforms/GPL96.yaml +4 -0
  249. data/install_scripts/GEO/platforms/GPL968.yaml +4 -0
  250. data/install_scripts/GEO/platforms/GPL97.yaml +4 -0
  251. data/install_scripts/GEO/platforms/GPL98.yaml +7 -0
  252. data/install_scripts/GEO/platforms/GPL981.yaml +7 -0
  253. data/install_scripts/GEO/platforms/GPL99.yaml +7 -0
  254. data/install_scripts/GEO/platforms/GPL999.yaml +7 -0
  255. data/install_scripts/GEO/series/GSE10018.yaml +61 -0
  256. data/install_scripts/GEO/series/GSE1002.yaml +135 -0
  257. data/install_scripts/GEO/series/GSE10066.yaml +31 -0
  258. data/install_scripts/GEO/series/GSE10073.yaml +19 -0
  259. data/install_scripts/GEO/series/GSE10091.yaml +15 -0
  260. data/install_scripts/GEO/series/GSE101.yaml +17 -0
  261. data/install_scripts/GEO/series/GSE10100.yaml +15 -0
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  267. data/install_scripts/GEO/series/GSE103.yaml +19 -0
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  270. data/install_scripts/GEO/series/GSE10521.yaml +56 -0
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  272. data/install_scripts/GEO/series/GSE1073.yaml +127 -0
  273. data/install_scripts/GEO/series/GSE10860.yaml +25 -0
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  300. data/install_scripts/GEO/series/GSE12104.yaml +10 -0
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  302. data/install_scripts/GEO/series/GSE12150.yaml +32 -0
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  305. data/install_scripts/GEO/series/GSE1365.yaml +14 -0
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  307. data/install_scripts/GEO/series/GSE1492.yaml +15 -0
  308. data/install_scripts/GEO/series/GSE15222.yaml +731 -0
  309. data/install_scripts/GEO/series/GSE1553.yaml +23 -0
  310. data/install_scripts/GEO/series/GSE1617.yaml +39 -0
  311. data/install_scripts/GEO/series/GSE1688.yaml +36 -0
  312. data/install_scripts/GEO/series/GSE1693.yaml +60 -0
  313. data/install_scripts/GEO/series/GSE1752.yaml +32 -0
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+
5
+ = partial 'menu', :selected => 'quick'
6
+
7
+
8
+ #video
9
+ =partial 'partials/video'
10
+
11
+ :redcloth
12
+
13
+ <br>
14
+ If you prefer, you can follow the Quick Start Guide
15
+ <a href="#TB_inline?height=410&width=640&inlineId=video" title="Quick Start Guide! video" class="thickbox">Video</a>
16
+ <br>
17
+
18
+ h1. Launching a Job
19
+
20
+ This section will walk you through launching a typical MARQ job.
21
+
22
+ h2. 1. Select the organism the genes belong to
23
+
24
+ !/images/guide/organism.png!
25
+
26
+ The default is to make a cross platform query. You may query an specific
27
+ platform only, but you must specify the genes in the original platform id
28
+ format.
29
+
30
+ h2. 2. Paste your genes of interest
31
+
32
+ ... in the up and down text areas. You may use one or both.
33
+
34
+ !/images/guide/genes.png!
35
+
36
+
37
+ h2. 3. Select a name for your job and click Submit
38
+
39
+ The name will be used to access the job at any latter time. If you do not
40
+ select one, a random one will be used.
41
+
42
+ !/images/guide/name.png!
43
+
44
+ h2. 4. Wait for the computations to finish.
45
+
46
+ Please be patient, it might take a few minutes. The server needs to compute
47
+ the results and generate the html report; and then the browser needs to
48
+ render the html. Due to the amount of data displayed, each of these steps
49
+ may take a while.
50
+
51
+ h1. Inspecting the Results
52
+
53
+ The results page shows a table with the results sorted by their relation to the
54
+ query. Be sure to check the top and bottom of the list; some signatures may
55
+ have the conditions swapped in the comparison. Signature with the keyword
56
+ [ratio] appended to the name did not have enough replicates to compute
57
+ t-values and have their signatures derived from the log-ratios.
58
+
59
+ The scores goes from -1 to 1 in the case of a single list query, and from
60
+ -2 to 2 for a two list query. Since the scores depend strongly on the size
61
+ of the query lists, the permutation based p-values, also shown, are a more
62
+ reliable measure of relevance. These p-values have been corrected for FDR.
63
+
64
+ *Click the <span class='toggle_example'>[+]</span> link to
65
+ display additional information* in for any of the signatures, including the dataset
66
+ description and images showing how the genes in the up and down lists.
67
+
68
+ Once the information is expanded, all the words in the description and title
69
+ (except for stopwords) will be click-able. *Click words to highlight signatures sharing that word*
70
+ and mark them in the adjoining hit-area, left of the table.
71
+
72
+ You may *double click on any place on the hit-area* to scroll the table
73
+ down to the corresponding signature.
74
+
75
+ !/images/guide/table.png!
76
+
77
+
78
+ h2. Examine annotations
79
+
80
+ Words are just one type of annotations for signatures. The annotation menu
81
+ shows additional annotations like GO terms.
82
+ Selecting any of them will display a table with the annotations that are
83
+ significantly over-represented at both extremes of the results list. Only
84
+ word annotations are loaded by default, all the rest will be loaded when
85
+ selected the first time, which might take a little while. This table can
86
+ also be clicked to mark relevant signatures in the hit-area. The p-values
87
+ are corrected for multiple testing.
88
+
89
+ !/images/guide/annotations.png!
90
+
91
+ h2. View gene hits for a signature
92
+
93
+ Click on the hit bar views for the signatures (the green horizontal bars) to see detailed
94
+ information about the positions of the query genes in the signature.
95
+
96
+ !/images/guide/hits.png!
97
+
98
+ Use the mouse to select interesting clusters of genes using click and drag
99
+ over the hit-area. Download those genes using the button 'Get Selected
100
+ Genes' to be used in another application like
101
+ "SENT":http://sent.dacya.ucm.es or
102
+ "GeneCodis":http://genecodis.dacya.ucm.es . Also, you may download the
103
+ log-ratios and t-values (if available for that signature) associated with
104
+ the query genes.
105
+
106
+ Each genes has a link to its description entry an external reference site,
107
+ and to its profile in the GEO dataset (not available for GEO series or
108
+ datasets from other sources).
109
+
110
+ h2. Compare signatures (Rank Product)
111
+
112
+ You may select two or more signatures to perform meta-analysis. Use the
113
+ check boxes in the 'Compare' column to select the signatures. The first
114
+ check box, after <span><notextile>&uarr</notextile></span> select the
115
+ signature as-is. The other one, after the
116
+ <span><notextile>&darr</notextile></span> inverts the order of the genes,
117
+ and can be used to compare against signatures that may have the conditions
118
+ swapped in the comparison (thus appearing in the bottom of the list when
119
+ they should be on the top). Then click the 'Compare signatures' button.
120
+
121
+ !/images/guide/compare.png!
122
+
123
+ The result of the meta-analysis compromises an up-regulated and a
124
+ down-regulated list of genes, which where found significantly de-regulated
125
+ in all the signatures using the Rank Product methodology. It also shows
126
+ separated tables for the genes in the up and down query lists.
127
+
128
+ !/images/guide/compare_page.png!
129
+
130
+ The complete details of the analysis can be downloaded in tab separated
131
+ format or in Excels xls. These files include, among other things, the log Rank
132
+ Product scores, the p-values, and whether the genes where included in the
133
+ original query lists. P-values are not FDR corrected, instead, we include
134
+ the PFP (equivalent to FDR) in the downloadable results.
135
+
136
+ h2. Download the signature information
137
+
138
+ You may download the log-ratios and t-values for all the genes in a signature from
139
+ the main results page.
140
+
141
+ !/images/guide/download.png!
142
+
143
+ Note that genes in these files are referenced by the applications internal
144
+ identifier format, which is usually the organism specific database id
145
+ format, as opposed to when they are downloaded from the hits page, where,
146
+ since only the genes in the query are included, they can be translated to
147
+ the original format used by the user.
148
+
149
+
@@ -0,0 +1,27 @@
1
+ !!!
2
+ %html
3
+ %head
4
+ %meta{ 'http-equiv' => 'Content-Type', :content => 'text/html;charset=utf-8' }
5
+ %title= @title
6
+
7
+ %link{ :rel => "shortcut icon", :href => "/images/favicon.ico"}
8
+ = css_include_tag('thickbox', 'marq', :bundle => 'marq_all')
9
+ = js_include_tag('wz_jsgraphics', 'jquery', 'jquery.scrollTo', 'jquery-ui.core', 'jquery-ui.hitarea', 'marq', 'jquery.tabs', 'thickbox','marq_pages', :bundle => 'marq_all')
10
+
11
+ %body
12
+ #layout
13
+ = partial 'partials/ie'
14
+ #header
15
+ %ul
16
+ %li.analysis
17
+ %a{:href => '/'} New analysis
18
+ %li.help
19
+ %a{:href => '/help'} Help
20
+ #content
21
+ = catch_content :for_layout
22
+ #clear_floats
23
+ #footer
24
+ :javascript
25
+ $('#header > ul > li.' + current).addClass('selected')
26
+
27
+
@@ -0,0 +1,96 @@
1
+
2
+ :javascript
3
+ current = 'analysis'
4
+ organisms = #{@organisms.to_json}
5
+
6
+ #main
7
+ #ad_video
8
+ Check out the
9
+ %a{ :href => "#TB_inline?height=410&width=640&inlineId=index_video", :title => "Quick Start Guide! video", :class => "thickbox"} Quick Start Guide Video
10
+
11
+ #index_video
12
+ = partial 'partials/video'
13
+
14
+ %form{:action => "/", :method => 'post'}
15
+ #genes
16
+ .textarea.parambox#up
17
+ %h2.boxtitle Up Regulated Genes
18
+ %textarea#ids_up{:name => :ids_up}
19
+ .textarea.parambox#down
20
+ %h2.boxtitle Down Regulated Genes
21
+ %textarea#ids_down{:name => :ids_down}
22
+ #fill
23
+ %span Zymolyase example (yeast):
24
+ %a.toggle{:href => "#", :onclick => "fill_ids()"} [Load example]
25
+ %a.toggle{:href => "Miguel_Zymolyase"} [Results]
26
+
27
+ #parameters
28
+
29
+ #organisms.parambox
30
+ %h2.boxtitle Organism
31
+
32
+ %p Please Select the organism the genes belong to
33
+ %select#organism{:name => :organism}
34
+ - @organisms.keys.sort{|a,b| a <=>b}.each do |org|
35
+ - p = @organisms[org]
36
+ %option{:value => org }= p[0]
37
+
38
+ #platforms.parambox
39
+ %h2.boxtitle Platform
40
+
41
+ %p
42
+
43
+ Select the platform the genes belong to. The genes must be in the
44
+ platform native format. If the Cross platform option is selected the
45
+ genes may be in any of the suported formats, as they will be
46
+ translated
47
+
48
+
49
+ %select#platform{:name => :platform}
50
+ %option#cross{:value =>'cross'} Cross platform query
51
+
52
+ #name.parambox
53
+ %h2.boxtitle Job Name
54
+ %p
55
+ Select a name for your job. A random one will be assigned if left blank
56
+ %input{ :name => :name}
57
+
58
+
59
+ #submit.parambox
60
+ %input{:type => 'submit'}
61
+
62
+ #logos
63
+ %hr
64
+ %center
65
+ %a{:href => "http://artecs.dacya.ucm.es/atc/homepage.php"}
66
+ %img{:src => "images/logo_ARTECS.jpg"}
67
+ %a{:href => "http://biocomp.cnb.uam.es/"}
68
+ %img{:src => "images/logo_BCU.jpg"}
69
+ %a{:href => "http://www.ucm.es/info/mfar/"}
70
+ %img{:src => "images/logo_MICRO.png"}
71
+
72
+ :javascript
73
+
74
+ function fill_ids(){
75
+
76
+ var up = "HSP12\nYLR042C\nRFX1\nYPL088W\nYHL010C\nYHR087W\nCRG1\nDAL7\nHAL1\nSRL3\nGPD1\nPRM5\nPRM10\nPST1\nFMP33\nYLR194C\nCTT1\nSLT2\nYLR040C\nYKE4\nDDR48\nYLR414C\nCWP1\nYMR315W\nPIR3\nYPS3\nYIL024C\nYGL157W\nSED1\nGAT1\nGRE3\nYGR146C\nOAZ1\nNQM1\nKTR2\nSPI1\nPCM1\nSTF2\nPPX1\nHMX1\nMDN1\nMSB3\nCAK1\nYCL049C\nSIP18\nPNS1\nFIR1\nSVS1\nGPG1\nDAN4\nYNL058C\nSYM1\nSBE22\nYET1\nRBK1\nCRH1\nALD4\nPGM2\nYDR262W\nKRE11\nMCH5\nGRE2\nNUP85\nECM4\nSOL4\nHOR2\nTMA10\nMSG5\nYJL171C\nYJR008W\nYML131W\nDFG5\nPNC1\nPRY2\nCIS3\nGDB1\nRCR1\nYOL019W\nORC6\nSWC7\nSPG5\nPET10\nATG8\nPEX27\nYKL161C\nICT1\nTFS1\nGOR1\nBGL2\nDOG2\nGFA1\nIAH1\nMSB4\nDCS2\nYJL160C\nTIR2\nSMF1\nBZZ1\nMSC1\nFYV8\nRGS2\nEXG1\nFAS2\nCIT1\nDUN1\nYHR097C\nYMR181C\nSOR1\nCHS7\nRCN2\nYEH1\nACA1\nYNL194C\nYML087C\nGTT1\nECM13\nYHR033W\nDOG1\nENT3\nTHI22\nMET28\nYKL151C\nATP22\nSOM1\nFRE2\nHXT1\nYSP3\nYPR1\nSOL1\nAGX1\nFMP48\nIML2\nMID2\nNCA3\nYDL114W\nYOL048C\nYNR065C\nSLU7\nPTP2\nYNL208W\nYKL121W\nVPS27\nHXK1\nMET16\nHSP32\nLSC2\nYMR090W\nSLD2\nYIL108W\nPRR1\nGIC2\nPRX1\nADD37\nCMK2\nYPL23HSP12\nYLR042C\nRFX1\nYPL088W\nYHL010C\nYHR087W\nCRG1\nDAL7\nHAL1\nSRL3\nGPD1\nPRM5\nPRM10\nPST1\nFMP33\nYLR194C\nCTT1\nSLT2\nYLR040C\nYKE4\nDDR48\nYLR414C\nCWP1\nYMR315W\nPIR3\nYPS3\nYIL024C\nYGL157W\nSED1\nGAT1\nGRE3\nYGR146C\nOAZ1\nNQM1\nKTR2\nSPI1\nPCM1\nSTF2\nPPX1\nHMX1\nMDN1\nMSB3\nCAK1\nYCL049C\nSIP18\nPNS1\nFIR1\nSVS1\nGPG1\nDAN4\nYNL058C\nSYM1\nSBE22\nYET1\nRBK1\nCRH1\nALD4\nPGM2\nYDR262W\nKRE11\nMCH5\nGRE2\nNUP85\nECM4\nSOL4\nHOR2\nTMA10\nMSG5\nYJL171C\nYJR008W\nYML131W\nDFG5\nPNC1\nPRY2\nCIS3\nGDB1\nRCR1\nYOL019W\nORC6\nSWC7\nSPG5\nPET10\nATG8\nPEX27\nYKL161C\nICT1\nTFS1\nGOR1\nBGL2\nDOG2\nGFA1\nIAH1\nMSB4\nDCS2\nYJL160C\nTIR2\nSMF1\nBZZ1\nMSC1\nFYV8\nRGS2\nEXG1\nFAS2\nCIT1\nDUN1\nYHR097C\nYMR181C\nSOR1\nCHS7\nRCN2\nYEH1\nACA1\nYNL194C\nYML087C\nGTT1\nECM13\nYHR033W\nDOG1\nENT3\nTHI22\nMET28\nYKL151C\nATP22\nSOM1\nFRE2\nHXT1\nYSP3\nYPR1\nSOL1\nAGX1\nFMP48\nIML2\nMID2\nNCA3\nYDL114W\nYOL048C\nYNR065C\nSLU7\nPTP2\nYNL208W\nYKL121W\nVPS27\nHXK1\nMET16\nHSP32\nLSC2\nYMR090W\nSLD2\nYIL108W\nPRR1\nGIC2\nPRX1\nADD37\nCMK2\nYPL230W"
77
+ var down = "NIP7\nRAS1\nBRX1\nYIL064W\nNSR1\nTPN1\nFET3\nILV5\nDBP2\nLIA1\nPHO5\nFCY2\nOPT1\nPHO11\nZRT2\nSSU1\nMRH1\nSHM2\nAAH1\nATO3\nPHO3\nYHB1\nPHO12\nLAP4"
78
+ $('#ids_up').attr('value',up);
79
+ $('#ids_down').attr('value',down);
80
+ $('#organism').attr('value',"sgd");
81
+ }
82
+
83
+ function organism_select(){
84
+ organism = $('select#organism').val();
85
+ $('select#platform option').not('#cross').remove();
86
+ $(organisms[organism][1]).each(function(){
87
+ $('select#platform').append('<option value="' + this + '" >' + this + '</option>')
88
+ })
89
+ }
90
+
91
+ $(function(){
92
+ $('select#organism').change(organism_select);
93
+ organism_select();
94
+ clear_textareas();
95
+
96
+ })
@@ -0,0 +1,51 @@
1
+ :javascript
2
+ current = 'translate'
3
+ #translate
4
+ %form{:method => 'post', :enctype => "multipart/form-data"}
5
+
6
+ #input
7
+ .parambox.select#organism
8
+ %h2.boxtitle Organism
9
+ %p
10
+ Select the organism the genes belong to
11
+ %select#org{:name => 'org'}
12
+ - @organisms.each do |org|
13
+ %option{:value => org, :selected => (org == 'human')}= org
14
+
15
+ .textarea.parambox#original
16
+ %h2.boxtitle Original Genes
17
+ %textarea#missing{:name => 'missing'}= @missing.join("\n")
18
+
19
+ #output
20
+ .parambox.select#format
21
+ %h2.boxtitle Target ID
22
+ %p
23
+ Select the format to which you wish the ids to be translated
24
+ %select#ids{:name => 'id'}
25
+ - @ids['human'].each do |id|
26
+ %option{:value => id}= id
27
+
28
+ .textarea.parambox#translations
29
+ %h2.boxtitle Translated Genes
30
+ %textarea#found{:name => 'found'}= @found.join("\n")
31
+
32
+ .parambox#submit.clear
33
+ %input{:type => 'submit'}
34
+
35
+ :javascript
36
+ eval('ids = #{@ids.to_json}')
37
+
38
+ $(function(){
39
+ $('select#org').change(function(){
40
+ $('select#ids').find('option').remove();
41
+ $(ids[$(this).val()]).each(function(){
42
+ $('select#ids').append("<option value='" + this + "'>" + this + "</option>")
43
+ })
44
+ })
45
+ $('select#org').val('human')
46
+ })
47
+
48
+ :javascript
49
+ $(function(){
50
+ clear_textareas()
51
+ })
@@ -0,0 +1,37 @@
1
+ #annotations
2
+ %h3#annotations_title
3
+ Annotations Menu
4
+ %a#close_annotations_menu{:href => '#'} [X]
5
+ %div
6
+ %label{:for => 'annotations_select'} Show:
7
+ %select#annotations_select
8
+ %option{:value => ""} Select one:
9
+ %option{:value => "Words"} Words
10
+ /%option{:value => "Polysearch"} Polysearch
11
+ /%option{:value => "UMLS"} UMLS
12
+ %option{:value => "GO_direct"} GO terms directly related
13
+ %option{:value => "GO_inverse"} GO terms inversely related
14
+ %option{:value => "GOSlim_direct"} GO Slim directly related
15
+ %option{:value => "GOSlim_inverse"} GO Slim inversely related
16
+ %hr
17
+ %div#enrichment_table_div
18
+ %table#enrichment_table
19
+ %thead
20
+ %tr
21
+ %th Term
22
+ %th P-Value
23
+ %tbody
24
+
25
+ :javascript
26
+ $('a#close_annotations_menu').click(function(){$('#annotations_menu').toggle('slow');return false;})
27
+
28
+ $('#annotations_select').val("");
29
+ $('#annotations_select').change(function(){
30
+ update_annotations_table();
31
+ if ($('#enrichment_table_div').hidden){
32
+ $('#enrichment_table_div').show();
33
+ }
34
+ }
35
+ );
36
+
37
+
@@ -0,0 +1,17 @@
1
+ - terms = info[:terms]
2
+ .table
3
+ %table
4
+ %thead
5
+ %tr
6
+ %th.term Term
7
+ %th.pvalue Value
8
+ %tbody
9
+ - terms.each do |p|
10
+ - term = p[0]
11
+ - value = p[1]
12
+ %tr
13
+ %td.term
14
+ %a.mark{:href => '#'}= term
15
+ %td.pvalue= "%1.3g" % value
16
+ :javascript
17
+ $('a.mark').click(function(){mark("Words", $(this).html());update_hits()} )
@@ -0,0 +1,33 @@
1
+ .exp_details
2
+ %h3.exp
3
+ Description
4
+ %span.dataset= span_words(info[:dataset], false)
5
+
6
+ %p.description
7
+
8
+ = span_words(info[:description])
9
+
10
+
11
+ %h3.exp
12
+ Hits
13
+ %a.logratios{:href => "/logratios?experiment=#{escapeURI(@experiment)}&job=#{@job}&genes="} [Get logratios]
14
+ - if @experiment !~ /\[ratio\]/
15
+ %a.ts{:href => "/ts?experiment=#{escapeURI(@experiment)}&job=#{@job}&genes="} [Get t-values]
16
+
17
+
18
+ - if info[:up]
19
+ %p.hits
20
+ %a.hits{:href => "/experiment_hits?job=#{ @job }&experiment=#{ escapeURI(@experiment) }&side=Up", :target => "_blank" }
21
+ U:
22
+ %img{:src => info[:up]}
23
+
24
+ - if info[:down]
25
+ %p.hits
26
+ %a.hits{:href => "/experiment_hits?job=#{ @job }&experiment=#{ escapeURI(@experiment) }&side=Down", :target => "_blank" }
27
+ D:
28
+ %img{:src => info[:down]}
29
+
30
+ %p.annotations
31
+ %ul.annotation_types
32
+
33
+
@@ -0,0 +1,19 @@
1
+ #ie_warning
2
+ If you are using
3
+ %span.ie internet explorer
4
+ and this site seems
5
+ %span very slow
6
+ you might
7
+ need to try a different browser like
8
+ %a{:href => "http://www.mozilla.com"} Firefox
9
+ ,
10
+ %a{:href => "http://www.apple.com/safari/"} Safari
11
+ or
12
+ %a{:href => "http://www.google.com/chrome/"} Google Chrome
13
+
14
+ :javascript
15
+ if (jQuery.browser.msie){
16
+ $('#ie_warning').show();
17
+ }
18
+
19
+
@@ -0,0 +1,5 @@
1
+ :redcloth
2
+ <center>
3
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+ </center>
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+
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+ :javascript
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+ current = '#{@job}';
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+
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+
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+ %h2#title
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+ Results for:
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+ %a.job{:href => "/#{ @job }"}= @job
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+ > Shared genes by selected signatures
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+
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+ #compare
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+ #genes_compare
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+ .menu_links
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+ %a.select_table.selected.button{:href => '#', :rel => 'table_up'} Top up regulated genes
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+ %a.select_table.button{:href => '#', :rel => 'table_down'} Top down regulated genes
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+ - if @genes_up.any?
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+ %a.select_table.button{:href => '#', :rel => 'table_query_up'} Genes in the up query
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+ - if @genes_down.any?
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+ %a.select_table.button{:href => '#', :rel => 'table_query_down'} Genes in the down query
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+ .clear_floats
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+
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+
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+ %table#table_genes_headers
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+ %thead
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+ %tr
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+ %th.name Name
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+ %th.synonyms Synonyms
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+ %th.pvalue P-Val
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+ %div.table_scroller
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+ - if @scores_up.any?
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+ %table#table_up.data
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+ %tbody
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+ - @sorted_up.each do |p|
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+ - gene = p[0]
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+ - score = p[1][0]
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+ - pvalue = p[1][1]
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+ %tr{:id => gene}
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+ %td.name
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+ - url = gene_url(@org, gene)
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+ - if url != nil
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+ %a.geneurl{:href => "#{url}"}= gene
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+ - else
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+ = gene
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+ %td.synonyms= @synonyms[gene].uniq.join(", ")
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+ %td.pvalue= print_pvalue pvalue, 0.00001
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+
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+ - if @scores_down.any?
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+ %table#table_down.data
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+ %tbody
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+ - @sorted_down.each do |p|
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+ - gene = p[0]
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+ - score = p[1][0]
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+ - pvalue = p[1][1]
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+ %tr{:id => gene}
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+ %td.name
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+ - url = gene_url(@org, gene)
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+ - if url != nil
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+ %a.geneurl{:href => "#{url}"}= gene
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+ - else
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+ = gene
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+ %td.synonyms= @synonyms[gene].uniq.join(", ")
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+ %td.pvalue= print_pvalue pvalue, 0.00001
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+
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+ - if @genes_up.any?
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+ %table#table_query_up.data
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+ %tbody
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+ - @scores_up.select{|gene, info| @genes_up.include? gene}.sort{|a,b| a[1][0] <=> b[1][0]}.each do |p|
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+ - gene = p[0]
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+ - used = @translations[gene]
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+ - score = p[1][0]
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+ - pvalue = p[1][1]
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+ %tr{:id => gene}
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+ %td.name
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+ - url = gene_url(@org,gene)
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+ - if gene != used
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+ -if url.nil?
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+ = "#{ used } (#{ gene })"
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+ - else
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+ %a.geneurl{:href => "#{url}"}= "#{ used } (#{ gene })"
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+ - else
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+ - if url.nil?
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+ = gene
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+ - else
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+ %a.geneurl{:href => "#{url}"}= gene
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+ %td.synonyms= @synonyms[gene].uniq.join(", ")
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+ %td.pvalue= print_pvalue pvalue, 0.00001
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+
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+ - if @genes_down.any?
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+ %table#table_query_down.data
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+ %tbody
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+ - @scores_down.select{|gene, info| @genes_down.include? gene}.sort{|a,b| a[1][0] <=> b[1][0]}.each do |p|
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+ - gene = p[0]
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+ - used = @translations[gene]
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+ - score = p[1][0]
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+ - pvalue = p[1][1]
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+ %tr{:id => gene}
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+ %td.name
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+ - url = gene_url(@org,gene)
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+ - if gene != used
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+ -if url.nil?
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+ = "#{ used } (#{ gene })"
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+ - else
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+ %a.geneurl{:href => "#{url}"}= "#{ used } (#{ gene })"
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+ - else
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+ - if url.nil?
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+ = gene
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+ - else
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+ %a.geneurl{:href => "#{url}"}= gene
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+ %td.synonyms= @synonyms[gene].uniq.join(", ")
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+ %td.pvalue= print_pvalue pvalue, 0.00001
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+
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+ .menu_links
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+ %a.tab.button{:href => @url + '&format=tsv'} Download in Tab Separated Values
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+ %a.excel.button{:href => @url + '&format=excel'} Download in Excel
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+ .clear_floats
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+
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+ :javascript
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+ function select_table(table){
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+ $('table.data').each(function(){
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+ if ($(this).attr('id') != table ){
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+ $(this).hide();
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+ }else{
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+ $(this).show();
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+ }
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+ })
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+ }
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+
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+ $(function(){
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+ select_table('table_up');
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+ $('.select_table').click(function(){
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+ select_table($(this).attr('rel'))
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+ return false
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+ })
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+ })
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+
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+ :javascript
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+
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+ function fit_size(){
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+ var scroller = $('.table_scroller');
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+ fit_window(scroller, 45)
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+ }
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+
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+
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+ $(function(){
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+ $('#genes_compare').width($('#table_genes_headers').width() + 20);
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+ fit_size();
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+
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+ $(".select_table").click(function () {
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+ $(".select_table").removeClass("selected");
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+ $(this).addClass("selected");
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+ });
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+
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+ $(window).resize(function(){
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+ fit_size();
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+ });
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+
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+ $("#genes_compare").tabs();
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+
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+ })
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+
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+
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+