lamindb 0.76.7__py3-none-any.whl → 0.76.8__py3-none-any.whl

lamindb/_curate.py

@@ -1,1601 +1,1601 @@
-from __future__ import annotations
-
-import copy
-from typing import TYPE_CHECKING, Iterable
-
-import anndata as ad
-import lamindb_setup as ln_setup
-import pandas as pd
-from lamin_utils import colors, logger
-from lamindb_setup.core._docs import doc_args
-from lnschema_core import (
-    Artifact,
-    Feature,
-    Record,
-    Run,
-    ULabel,
-)
-
-from .core.exceptions import ValidationError
-
-if TYPE_CHECKING:
-    from lamindb_setup.core.types import UPathStr
-    from lnschema_core.types import FieldAttr
-    from mudata import MuData
-
-
-class CurateLookup:
-    """Lookup categories from the reference instance."""
-
-    def __init__(
-        self,
-        categoricals: dict[str, FieldAttr],
-        slots: dict[str, FieldAttr] = None,
-        using_key: str | None = None,
-    ) -> None:
-        if slots is None:
-            slots = {}
-        self._fields = {**categoricals, **slots}
-        self._using_key = None if using_key == "default" else using_key
-        self._using_key_name = self._using_key or ln_setup.settings.instance.slug
-        debug_message = (
-            f"Lookup objects from the " f"{colors.italic(self._using_key_name)}"
-        )
-        logger.debug(debug_message)
-
-    def __getattr__(self, name):
-        if name in self._fields:
-            registry = self._fields[name].field.model
-            if self._using_key == "public":
-                return registry.public().lookup()
-            else:
-                return get_registry_instance(registry, self._using_key).lookup()
-        raise AttributeError(
-            f"'{self.__class__.__name__}' object has no attribute '{name}'"
-        )
-
-    def __getitem__(self, name):
-        if name in self._fields:
-            registry = self._fields[name].field.model
-            if self._using_key == "public":
-                return registry.public().lookup()
-            else:
-                return get_registry_instance(registry, self._using_key).lookup()
-        raise AttributeError(
-            f"'{self.__class__.__name__}' object has no attribute '{name}'"
-        )
-
-    def __repr__(self) -> str:
-        if len(self._fields) > 0:
-            getattr_keys = "\n ".join(
-                [f".{key}" for key in self._fields if key.isidentifier()]
-            )
-            getitem_keys = "\n ".join(
-                [str([key]) for key in self._fields if not key.isidentifier()]
-            )
-            return (
-                f"Lookup objects from the {colors.italic(self._using_key_name)}:\n "
-                f"{colors.green(getattr_keys)}\n "
-                f"{colors.green(getitem_keys)}\n\n"
-                "Example:\n    → categories = validator.lookup().cell_type\n"
-                "    → categories.alveolar_type_1_fibroblast_cell"
-            )
-        else:  # pragma: no cover
-            return colors.warning("No fields are found!")
-
-
-class BaseCurator:
-    """Curate a dataset."""
-
-    def validate(self) -> bool:
-        """Validate dataset.
-
-        Returns:
-            Boolean indicating whether the dataset is validated.
-        """
-        pass
-
-    def save_artifact(self, description: str | None = None, **kwargs) -> Artifact:
-        """Save the dataset as artifact.
-
-        Args:
-            description: Description of the DataFrame object.
-            **kwargs: Object level metadata.
-
-        Returns:
-            A saved artifact record.
-        """
-        pass
-
-
-class DataFrameCurator(BaseCurator):
-    """Curation flow for a DataFrame object.
-
-    See also :class:`~lamindb.Curator`.
-
-    Args:
-        df: The DataFrame object to curate.
-        columns: The field attribute for the feature column.
-        categoricals: A dictionary mapping column names to registry_field.
-        using_key: The reference instance containing registries to validate against.
-        verbosity: The verbosity level.
-        organism: The organism name.
-        sources: A dictionary mapping column names to Source records.
-        exclude: A dictionary mapping column names to values to exclude.
-
-    Examples:
-        >>> import bionty as bt
-        >>> curate = ln.Curator.from_df(
-        ...     df,
-        ...     categoricals={
-        ...         "cell_type_ontology_id": bt.CellType.ontology_id,
-        ...         "donor_id": ln.ULabel.name
-        ...     }
-        ... )
-    """
-
-    def __init__(
-        self,
-        df: pd.DataFrame,
-        columns: FieldAttr = Feature.name,
-        categoricals: dict[str, FieldAttr] | None = None,
-        using_key: str | None = None,
-        verbosity: str = "hint",
-        organism: str | None = None,
-        sources: dict[str, Record] | None = None,
-        exclude: dict | None = None,
-        check_valid_keys: bool = True,
-    ) -> None:
-        from lamindb.core._settings import settings
-
-        self._df = df
-        self._fields = categoricals or {}
-        self._columns_field = columns
-        self._using_key = using_key
-        settings.verbosity = verbosity
-        self._artifact = None
-        self._collection = None
-        self._validated = False
-        self._kwargs = {"organism": organism} if organism else {}
-        if sources is None:
-            sources = {}
-        self._sources = sources
-        if exclude is None:
-            exclude = {}
-        self._exclude = exclude
-        self._non_validated = None
-        if check_valid_keys:
-            self._check_valid_keys()
-        self._save_columns()
-
-    @property
-    def non_validated(self) -> list:
-        """Return the non-validated features and labels."""
-        if self._non_validated is None:
-            raise ValueError("Please run validate() first!")
-        return self._non_validated
-
-    @property
-    def fields(self) -> dict:
-        """Return the columns fields to validate against."""
-        return self._fields
-
-    def lookup(self, using_key: str | None = None) -> CurateLookup:
-        """Lookup categories.
-
-        Args:
-            using_key: The instance where the lookup is performed.
-                if None (default), the lookup is performed on the instance specified in "using_key" parameter of the validator.
-                if "public", the lookup is performed on the public reference.
-        """
-        return CurateLookup(
-            categoricals=self._fields,
-            slots={"columns": self._columns_field},
-            using_key=using_key or self._using_key,
-        )
-
-    def _check_valid_keys(self, extra: set = None) -> None:
-        if extra is None:
-            extra = set()
-        for name, d in {
-            "categoricals": self._fields,
-            "sources": self._sources,
-            "exclude": self._exclude,
-        }.items():
-            if not isinstance(d, dict):
-                raise TypeError(f"{name} must be a dictionary!")
-            valid_keys = set(self._df.columns) | {"columns"} | extra
-            nonval_keys = [key for key in d.keys() if key not in valid_keys]
-            if len(nonval_keys) > 0:
-                raise ValueError(
-                    f"the following keys passed to {name} are not allowed: {nonval_keys}"
-                )
-
-    def _save_columns(self, validated_only: bool = True, **kwargs) -> None:
-        """Save column name records."""
-        # Always save features specified as the fields keys
-        update_registry(
-            values=list(self.fields.keys()),
-            field=self._columns_field,
-            key="columns",
-            save_function="add_new_from_columns",
-            using_key=self._using_key,
-            validated_only=False,
-            source=self._sources.get("columns"),
-            exclude=self._exclude.get("columns"),
-            **kwargs,
-        )
-
-        # Save the rest of the columns based on validated_only
-        additional_columns = set(self._df.columns) - set(self.fields.keys())
-        if additional_columns:
-            update_registry(
-                values=list(additional_columns),
-                field=self._columns_field,
-                key="columns",
-                save_function="add_new_from_columns",
-                using_key=self._using_key,
-                validated_only=validated_only,
-                df=self._df,  # Get the Feature type from df
-                source=self._sources.get("columns"),
-                exclude=self._exclude.get("columns"),
-                warning=False,  # Do not warn about missing columns, just an info message
-                **kwargs,
-            )
-
-    def add_validated_from(self, key: str, organism: str | None = None):
-        """Add validated categories.
-
-        Args:
-            key: The key referencing the slot in the DataFrame.
-            organism: The organism name.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        self._update_registry(key, validated_only=True, **self._kwargs)
-
-    def add_new_from(self, key: str, organism: str | None = None, **kwargs):
-        """Add validated & new categories.
-
-        Args:
-            key: The key referencing the slot in the DataFrame from which to draw terms.
-            organism: The organism name.
-            **kwargs: Additional keyword arguments to pass to the registry model.
-        """
-        if len(kwargs) > 0 and key == "all":
-            raise ValueError("Cannot pass additional arguments to 'all' key!")
-        self._kwargs.update({"organism": organism} if organism else {})
-        self._update_registry(key, validated_only=False, **self._kwargs, **kwargs)
-
-    def add_new_from_columns(self, organism: str | None = None, **kwargs):
-        """Add validated & new column names to its registry.
-
-        Args:
-            organism: The organism name.
-            **kwargs: Additional keyword arguments to pass to the registry model.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        self._save_columns(validated_only=False, **self._kwargs, **kwargs)
-
-    def _update_registry(self, categorical: str, validated_only: bool = True, **kwargs):
-        if categorical == "all":
-            self._update_registry_all(validated_only=validated_only, **kwargs)
-        elif categorical == "columns":
-            self._save_columns(validated_only=validated_only, **kwargs)
-        else:
-            if categorical not in self.fields:
-                raise ValueError(f"Feature {categorical} is not part of the fields!")
-            update_registry(
-                values=self._df[categorical].unique().tolist(),
-                field=self.fields[categorical],
-                key=categorical,
-                using_key=self._using_key,
-                validated_only=validated_only,
-                source=self._sources.get(categorical),
-                exclude=self._exclude.get(categorical),
-                **kwargs,
-            )
-
-    def _update_registry_all(self, validated_only: bool = True, **kwargs):
-        """Save labels for all features."""
-        for name in self.fields.keys():
-            logger.info(f"saving labels for '{name}'")
-            self._update_registry(name, validated_only=validated_only, **kwargs)
-
-    def validate(self, organism: str | None = None) -> bool:
-        """Validate variables and categorical observations.
-
-        Args:
-            organism: The organism name.
-
-        Returns:
-            Whether the DataFrame is validated.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        self._validated, self._non_validated = validate_categories_in_df(  # type: ignore
-            self._df,
-            fields=self.fields,
-            using_key=self._using_key,
-            sources=self._sources,
-            exclude=self._exclude,
-            **self._kwargs,
-        )
-        return self._validated
-
-    def save_artifact(self, description: str | None = None, **kwargs) -> Artifact:
-        """Save the validated DataFrame and metadata.
-
-        Args:
-            description: Description of the DataFrame object.
-            **kwargs: Object level metadata.
-
-        Returns:
-            A saved artifact record.
-        """
-        from lamindb.core._settings import settings
-
-        if not self._validated:
-            self.validate()
-            if not self._validated:
-                raise ValidationError("Dataset does not validate. Please curate.")
-
-        # Make sure all labels are saved in the current instance
-        verbosity = settings.verbosity
-        try:
-            settings.verbosity = "warning"
-            # save all validated records to the current instance
-            self.add_validated_from("all")
-
-            self._artifact = save_artifact(
-                self._df,
-                description=description,
-                fields=self.fields,
-                columns_field=self._columns_field,
-                **kwargs,
-                **self._kwargs,
-            )
-        finally:
-            settings.verbosity = verbosity
-
-        return self._artifact
-
-    def clean_up_failed_runs(self):
-        """Clean up previous failed runs that don't save any outputs."""
-        from lamindb.core._context import context
-
-        if context.run is not None:
-            Run.filter(transform=context.run.transform, output_artifacts=None).exclude(
-                uid=context.run.uid
-            ).delete()
-
-
-class AnnDataCurator(DataFrameCurator):
-    """Curation flow for ``AnnData``.
-
-    See also :class:`~lamindb.Curator`.
-
-    Note that if genes are removed from the AnnData object, the object should be recreated using :meth:`~lamindb.Curator.from_anndata`.
-
-    See :doc:`docs:cellxgene-curate` for instructions on how to curate against a specific cellxgene schema version.
-
-    Args:
-        data: The AnnData object or an AnnData-like path.
-        var_index: The registry field for mapping the ``.var`` index.
-        categoricals: A dictionary mapping ``.obs.columns`` to a registry field.
-        using_key: A reference LaminDB instance.
-        verbosity: The verbosity level.
-        organism: The organism name.
-        sources: A dictionary mapping ``.obs.columns`` to Source records.
-        exclude: A dictionary mapping column names to values to exclude.
-
-    Examples:
-        >>> import bionty as bt
-        >>> curate = ln.Curator.from_anndata(
-        ...     adata,
-        ...     var_index=bt.Gene.ensembl_gene_id,
-        ...     categoricals={
-        ...         "cell_type_ontology_id": bt.CellType.ontology_id,
-        ...         "donor_id": ln.ULabel.name
-        ...     },
-        ...     organism="human",
-        ... )
-    """
-
-    def __init__(
-        self,
-        data: ad.AnnData | UPathStr,
-        var_index: FieldAttr,
-        categoricals: dict[str, FieldAttr] | None = None,
-        obs_columns: FieldAttr = Feature.name,
-        using_key: str = "default",
-        verbosity: str = "hint",
-        organism: str | None = None,
-        sources: dict[str, Record] | None = None,
-        exclude: dict | None = None,
-    ) -> None:
-        from lamindb_setup.core import upath
-
-        from ._artifact import data_is_anndata
-
-        if sources is None:
-            sources = {}
-        if not data_is_anndata(data):
-            raise ValueError(
-                "data has to be an AnnData object or a path to AnnData-like"
-            )
-        if isinstance(data, ad.AnnData):
-            self._adata = data
-        else:  # pragma: no cover
-            from lamindb.core.storage._backed_access import backed_access
-
-            self._adata = backed_access(upath.create_path(data))
-
-        self._data = data
-        self._var_field = var_index
-        super().__init__(
-            df=self._adata.obs,
-            categoricals=categoricals,
-            columns=obs_columns,
-            using_key=using_key,
-            verbosity=verbosity,
-            organism=organism,
-            sources=sources,
-            exclude=exclude,
-            check_valid_keys=False,
-        )
-        self._obs_fields = categoricals or {}
-        self._check_valid_keys(extra={"var_index"})
-
-    @property
-    def var_index(self) -> FieldAttr:
-        """Return the registry field to validate variables index against."""
-        return self._var_field
-
-    @property
-    def categoricals(self) -> dict:
-        """Return the obs fields to validate against."""
-        return self._obs_fields
-
-    def lookup(self, using_key: str | None = None) -> CurateLookup:
-        """Lookup categories.
-
-        Args:
-            using_key: The instance where the lookup is performed.
-                if None (default), the lookup is performed on the instance specified in "using" parameter of the validator.
-                if "public", the lookup is performed on the public reference.
-        """
-        return CurateLookup(
-            categoricals=self._obs_fields,
-            slots={"columns": self._columns_field, "var_index": self._var_field},
-            using_key=using_key or self._using_key,
-        )
-
-    def _save_from_var_index(
-        self, validated_only: bool = True, organism: str | None = None
-    ):
-        """Save variable records."""
-        update_registry(
-            values=list(self._adata.var.index),
-            field=self.var_index,
-            key="var_index",
-            save_function="add_new_from_var_index",
-            using_key=self._using_key,
-            validated_only=validated_only,
-            organism=organism,
-            source=self._sources.get("var_index"),
-            exclude=self._exclude.get("var_index"),
-        )
-
-    def _update_registry_all(self, validated_only: bool = True, **kwargs):
-        """Save labels for all features."""
-        for name in self.fields.keys():
-            logger.info(f"saving labels for '{name}'")
-            if name == "var_index":
-                self._save_from_var_index(validated_only=validated_only, **kwargs)
-            else:
-                self._update_registry(name, validated_only=validated_only, **kwargs)
-
-    def add_new_from_var_index(self, organism: str | None = None, **kwargs):
-        """Update variable records.
-
-        Args:
-            organism: The organism name.
-            **kwargs: Additional keyword arguments to pass to the registry model.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        self._save_from_var_index(validated_only=False, **self._kwargs, **kwargs)
-
-    def add_validated_from_var_index(self, organism: str | None = None):
-        """Add validated variable records.
-
-        Args:
-            organism: The organism name.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        self._save_from_var_index(validated_only=True, **self._kwargs)
-
-    def validate(self, organism: str | None = None) -> bool:
-        """Validate categories.
-
-        Args:
-            organism: The organism name.
-
-        Returns:
-            Whether the AnnData object is validated.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        if self._using_key is not None and self._using_key != "default":
-            logger.important(
-                f"validating metadata using registries of instance {colors.italic(self._using_key)}"
-            )
-
-        validated_var, non_validated_var = validate_categories(
-            self._adata.var.index,
-            field=self._var_field,
-            key="var_index",
-            using_key=self._using_key,
-            source=self._sources.get("var_index"),
-            validated_hint_print=".add_validated_from_var_index()",
-            exclude=self._exclude.get("var_index"),
-            **self._kwargs,  # type: ignore
-        )
-        validated_obs, non_validated_obs = validate_categories_in_df(
-            self._adata.obs,
-            fields=self.categoricals,
-            using_key=self._using_key,
-            sources=self._sources,
-            exclude=self._exclude,
-            **self._kwargs,
-        )
-        self._non_validated = non_validated_obs  # type: ignore
-        if len(non_validated_var) > 0:
-            self._non_validated["var_index"] = non_validated_var  # type: ignore
-        self._validated = validated_var and validated_obs
-        return self._validated
-
-    def save_artifact(self, description: str | None = None, **kwargs) -> Artifact:
-        """Save the validated ``AnnData`` and metadata.
-
-        Args:
-            description: Description of the ``AnnData`` object.
-            **kwargs: Object level metadata.
-
-        Returns:
-            A saved artifact record.
-        """
-        if not self._validated:
-            self.validate()
-            if not self._validated:
-                raise ValidationError("Dataset does not validate. Please curate.")
-
-        self._artifact = save_artifact(
-            self._data,
-            adata=self._adata,
-            description=description,
-            columns_field=self.var_index,
-            fields=self.categoricals,
-            **self._kwargs,
-            **kwargs,
-        )
-        return self._artifact
-
-
-class MuDataCurator:
-    """Curation flow for a ``MuData`` object.
-
-    See also :class:`~lamindb.Curator`.
-
-    Note that if genes or other measurements are removed from the MuData object,
-    the object should be recreated using :meth:`~lamindb.Curator.from_mudata`.
-
-    Args:
-        mdata: The MuData object to curate.
-        var_index: The registry field for mapping the ``.var`` index for each modality.
-            For example:
-            ``{"modality_1": bt.Gene.ensembl_gene_id, "modality_2": ln.CellMarker.name}``
-        categoricals: A dictionary mapping ``.obs.columns`` to a registry field.
-            Use modality keys to specify categoricals for MuData slots such as `"rna:cell_type": bt.CellType.name"`.
-        using_key: A reference LaminDB instance.
-        verbosity: The verbosity level.
-        organism: The organism name.
-        sources: A dictionary mapping ``.obs.columns`` to Source records.
-        exclude: A dictionary mapping column names to values to exclude.
-
-    Examples:
-        >>> import bionty as bt
-        >>> curate = ln.Curator.from_mudata(
-        ...     mdata,
-        ...     var_index={
-        ...         "rna": bt.Gene.ensembl_gene_id,
-        ...         "adt": ln.CellMarker.name
-        ...     },
-        ...     categoricals={
-        ...         "cell_type_ontology_id": bt.CellType.ontology_id,
-        ...         "donor_id": ln.ULabel.name
-        ...     },
-        ...     organism="human",
-        ... )
-    """
-
-    def __init__(
-        self,
-        mdata: MuData,
-        var_index: dict[str, dict[str, FieldAttr]],
-        categoricals: dict[str, FieldAttr] | None = None,
-        using_key: str = "default",
-        verbosity: str = "hint",
-        organism: str | None = None,
-        sources: dict[str, Record] | None = None,
-        exclude: dict | None = None,
-    ) -> None:
-        if sources is None:
-            sources = {}
-        self._sources = sources
-        if exclude is None:
-            exclude = {}
-        self._exclude = exclude
-        self._mdata = mdata
-        self._kwargs = {"organism": organism} if organism else {}
-        self._var_fields = var_index
-        self._verify_modality(self._var_fields.keys())
-        self._obs_fields = self._parse_categoricals(categoricals)
-        self._modalities = set(self._var_fields.keys()) | set(self._obs_fields.keys())
-        self._using_key = using_key
-        self._verbosity = verbosity
-        self._df_annotators = {
-            modality: DataFrameCurator(
-                df=mdata[modality].obs if modality != "obs" else mdata.obs,
-                categoricals=self._obs_fields.get(modality, {}),
-                using_key=using_key,
-                verbosity=verbosity,
-                sources=self._sources.get(modality),
-                exclude=self._exclude.get(modality),
-                check_valid_keys=False,
-                **self._kwargs,
-            )
-            for modality in self._modalities
-        }
-        for modality in self._var_fields.keys():
-            self._save_from_var_index_modality(
-                modality=modality, validated_only=True, **self._kwargs
-            )
-
-    @property
-    def var_index(self) -> FieldAttr:
-        """Return the registry field to validate variables index against."""
-        return self._var_fields
-
-    @property
-    def categoricals(self) -> dict:
-        """Return the obs fields to validate against."""
-        return self._obs_fields
-
-    def _verify_modality(self, modalities: Iterable[str]):
-        """Verify the modality exists."""
-        for modality in modalities:
-            if modality not in self._mdata.mod.keys():
-                raise ValueError(f"modality '{modality}' does not exist!")
-
-    def _save_from_var_index_modality(
-        self, modality: str, validated_only: bool = True, **kwargs
-    ):
-        """Save variable records."""
-        update_registry(
-            values=list(self._mdata[modality].var.index),
-            field=self._var_fields[modality],
-            key="var_index",
-            save_function="add_new_from_var_index",
-            using_key=self._using_key,
-            validated_only=validated_only,
-            dtype="number",
-            source=self._sources.get(modality, {}).get("var_index"),
-            exclude=self._exclude.get(modality, {}).get("var_index"),
-            **kwargs,
-        )
-
-    def _parse_categoricals(self, categoricals: dict[str, FieldAttr]) -> dict:
-        """Parse the categorical fields."""
-        prefixes = {f"{k}:" for k in self._mdata.mod.keys()}
-        obs_fields: dict[str, dict[str, FieldAttr]] = {}
-        for k, v in categoricals.items():
-            if k not in self._mdata.obs.columns:
-                raise ValueError(f"column '{k}' does not exist in mdata.obs!")
-            if any(k.startswith(prefix) for prefix in prefixes):
-                modality, col = k.split(":")[0], k.split(":")[1]
-                if modality not in obs_fields.keys():
-                    obs_fields[modality] = {}
-                obs_fields[modality][col] = v
-            else:
-                if "obs" not in obs_fields.keys():
-                    obs_fields["obs"] = {}
-                obs_fields["obs"][k] = v
-        return obs_fields
-
-    def lookup(self, using_key: str | None = None) -> CurateLookup:
-        """Lookup categories.
-
-        Args:
-            using_key: The instance where the lookup is performed.
-                if None (default), the lookup is performed on the instance specified in "using_key" parameter of the validator.
-                if "public", the lookup is performed on the public reference.
-        """
-        return CurateLookup(
-            categoricals=self._obs_fields,
-            slots={
-                **self._obs_fields,
-                **{f"{k}_var_index": v for k, v in self._var_fields.items()},
-            },
-            using_key=using_key or self._using_key,
-        )
-
-    def add_new_from_columns(
-        self,
-        modality: str,
-        column_names: list[str] | None = None,
-        organism: str | None = None,
-        **kwargs,
-    ):
-        """Update columns records.
-
-        Args:
-            modality: The modality name.
-            column_names: The column names to save.
-            organism: The organism name.
-            **kwargs: Additional keyword arguments to pass to the registry model.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        values = column_names or self._mdata[modality].obs.columns
-        update_registry(
-            values=list(values),
-            field=Feature.name,
-            key=f"{modality} obs columns",
-            using_key=self._using_key,
-            validated_only=False,
-            df=self._mdata[modality].obs,
-            source=self._sources.get(modality, {}).get("columns"),
-            exclude=self._exclude.get(modality, {}).get("columns"),
-            **self._kwargs,  # type: ignore
-            **kwargs,
-        )
-
-    def add_new_from_var_index(
-        self, modality: str, organism: str | None = None, **kwargs
-    ):
-        """Update variable records.
-
-        Args:
-            modality: The modality name.
-            organism: The organism name.
-            **kwargs: Additional keyword arguments to pass to the registry model.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        self._save_from_var_index_modality(
-            modality=modality, validated_only=False, **self._kwargs, **kwargs
-        )
-
-    def add_validated_from_var_index(self, modality: str, organism: str | None = None):
-        """Add validated variable records.
-
-        Args:
-            modality: The modality name.
-            organism: The organism name.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        self._save_from_var_index_modality(
-            modality=modality, validated_only=True, **self._kwargs
-        )
-
-    def add_validated_from(
-        self, key: str, modality: str | None = None, organism: str | None = None
-    ):
-        """Add validated categories.
-
-        Args:
-            key: The key referencing the slot in the DataFrame.
-            modality: The modality name.
-            organism: The organism name.
-        """
-        self._kwargs.update({"organism": organism} if organism else {})
-        modality = modality or "obs"
-        if modality in self._df_annotators:
-            df_annotator = self._df_annotators[modality]
-            df_annotator.add_validated_from(key=key, **self._kwargs)
-
-    def add_new_from(
-        self,
-        key: str,
-        modality: str | None = None,
-        organism: str | None = None,
-        **kwargs,
-    ):
-        """Add validated & new categories.
-
-        Args:
-            key: The key referencing the slot in the DataFrame.
-            modality: The modality name.
-            organism: The organism name.
-            **kwargs: Additional keyword arguments to pass to the registry model.
-        """
-        if len(kwargs) > 0 and key == "all":
-            raise ValueError("Cannot pass additional arguments to 'all' key!")
-        self._kwargs.update({"organism": organism} if organism else {})
-        modality = modality or "obs"
-        if modality in self._df_annotators:
-            df_annotator = self._df_annotators[modality]
-            df_annotator.add_new_from(key=key, **self._kwargs, **kwargs)
-
-    def validate(self, organism: str | None = None) -> bool:
-        """Validate categories."""
-        self._kwargs.update({"organism": organism} if organism else {})
-        if self._using_key is not None and self._using_key != "default":
-            logger.important(
-                f"validating metadata using registries of instance {colors.italic(self._using_key)}"
-            )
-        validated_var = True
-        non_validated_var_modality = {}
-        for modality, var_field in self._var_fields.items():
-            is_validated_var, non_validated_var = validate_categories(
-                self._mdata[modality].var.index,
-                field=var_field,
-                key=f"{modality}_var_index",
-                using_key=self._using_key,
-                source=self._sources.get(modality, {}).get("var_index"),
-                exclude=self._exclude.get(modality, {}).get("var_index"),
-                **self._kwargs,  # type: ignore
-            )
-            validated_var &= is_validated_var
-            if len(non_validated_var) > 0:
-                non_validated_var_modality[modality] = non_validated_var
-
-        validated_obs = True
-        non_validated_obs_modality = {}
-        for modality, fields in self._obs_fields.items():
-            if modality == "obs":
-                obs = self._mdata.obs
-            else:
-                obs = self._mdata[modality].obs
-            is_validated_obs, non_validated_obs = validate_categories_in_df(
-                obs,
-                fields=fields,
-                using_key=self._using_key,
-                sources=self._sources.get(modality),
-                exclude=self._exclude.get(modality),
-                **self._kwargs,
-            )
-            validated_obs &= is_validated_obs
-            non_validated_obs_modality[modality] = non_validated_obs
-            if modality in non_validated_var_modality:
-                non_validated_obs_modality[modality]["var_index"] = (
-                    non_validated_var_modality[modality]
-                )
-            if len(non_validated_obs_modality[modality]) > 0:
-                self._non_validated = non_validated_obs_modality[modality]
-        self._validated = validated_var and validated_obs
-        return self._validated
-
-    def save_artifact(self, description: str | None = None, **kwargs) -> Artifact:
-        """Save the validated ``MuData`` and metadata.
-
-        Args:
-            description: Description of the ``MuData`` object.
-            **kwargs: Object level metadata.
-
-        Returns:
-            A saved artifact record.
-        """
-        if not self._validated:
-            raise ValidationError("Please run `validate()` first!")
-
-        self._artifact = save_artifact(
-            self._mdata,
-            description=description,
-            columns_field=self.var_index,
-            fields=self.categoricals,
-            **self._kwargs,
-            **kwargs,
-        )
-        return self._artifact
-
-
-class Curator(BaseCurator):
-    """Dataset curator.
-
-    Data curation entails accurately labeling datasets with standardized metadata
-    to facilitate data integration, interpretation and analysis.
-
-    The curation flow has several steps:
-
-    1. Instantiate `Curator` from one of the following dataset objects:
-
-    - :meth:`~lamindb.Curator.from_df`
-    - :meth:`~lamindb.Curator.from_anndata`
-    - :meth:`~lamindb.Curator.from_mudata`
-
-    During object creation, any passed categoricals found in the object will be saved.
-
-    2. Run :meth:`~lamindb.core.DataFrameCurator.validate` to check the data against the defined criteria. This method identifies:
-
-    - Values that can successfully validated and already exist in the registry.
-    - Values which are new and not yet validated or potentially problematic values.
-
-    3. Determine how to handle validated and non-validated values:
-
-    - Validated values not yet in the registry can be automatically registered using :meth:`~lamindb.core.DataFrameCurator.add_validated_from`.
-    - Valid and new values can be registered using :meth:`~lamindb.core.DataFrameCurator.add_new_from`.
-    - All unvalidated values can be accessed using :meth:`~lamindb.core.DataFrameCurator.non_validated` and subsequently removed from the object at hand.
-    """
-
-    @classmethod
-    @doc_args(DataFrameCurator.__doc__)
-    def from_df(
-        cls,
-        df: pd.DataFrame,
-        categoricals: dict[str, FieldAttr] | None = None,
-        columns: FieldAttr = Feature.name,
-        using_key: str | None = None,
-        verbosity: str = "hint",
-        organism: str | None = None,
-    ) -> DataFrameCurator:
-        """{}"""  # noqa: D415
-        return DataFrameCurator(
-            df=df,
-            categoricals=categoricals,
-            columns=columns,
-            using_key=using_key,
-            verbosity=verbosity,
-            organism=organism,
-        )
-
-    @classmethod
-    @doc_args(AnnDataCurator.__doc__)
-    def from_anndata(
-        cls,
-        data: ad.AnnData | UPathStr,
-        var_index: FieldAttr,
-        categoricals: dict[str, FieldAttr] | None = None,
-        obs_columns: FieldAttr = Feature.name,
-        using_key: str = "default",
-        verbosity: str = "hint",
-        organism: str | None = None,
-        sources: dict[str, Record] | None = None,
-    ) -> AnnDataCurator:
-        """{}"""  # noqa: D415
-        return AnnDataCurator(
-            data=data,
-            var_index=var_index,
-            categoricals=categoricals,
-            obs_columns=obs_columns,
-            using_key=using_key,
-            verbosity=verbosity,
-            organism=organism,
-            sources=sources,
-        )
-
-    @classmethod
-    @doc_args(MuDataCurator.__doc__)
-    def from_mudata(
-        cls,
-        mdata: MuData,
-        var_index: dict[str, dict[str, FieldAttr]],
-        categoricals: dict[str, FieldAttr] | None = None,
-        using_key: str = "default",
-        verbosity: str = "hint",
-        organism: str | None = None,
-    ) -> MuDataCurator:
-        """{}"""  # noqa: D415
-        return MuDataCurator(
-            mdata=mdata,
-            var_index=var_index,
-            categoricals=categoricals,
-            using_key=using_key,
-            verbosity=verbosity,
-            organism=organism,
-        )
-
-
-def get_registry_instance(registry: Record, using_key: str | None = None) -> Record:
-    """Get a registry instance using a specific instance."""
-    if using_key is not None and using_key != "default":
-        return registry.using(using_key)
-    return registry
-
-
-def get_current_filter_kwargs(registry: type[Record], kwargs: dict) -> dict:
-    """Make sure the source and organism are saved in the same database as the registry."""
-    from lamindb.core._settings import settings
-
-    db = registry.filter().db
-    source = kwargs.get("source")
-    organism = kwargs.get("organism")
-    filter_kwargs = kwargs.copy()
-    try:
-        verbosity = settings.verbosity
-        settings.verbosity = "error"
-        if isinstance(organism, Record) and organism._state.db != "default":
-            if db is None or db == "default":
-                organism_default = copy.copy(organism)
-                # save the organism record in the default database
-                organism_default.save()
-                filter_kwargs["organism"] = organism_default
-        if isinstance(source, Record) and source._state.db != "default":
-            if db is None or db == "default":
-                source_default = copy.copy(source)
-                # save the source record in the default database
-                source_default.save()
-                filter_kwargs["source"] = source_default
-    finally:
-        settings.verbosity = verbosity
-    return filter_kwargs
-
-
-def standardize_and_inspect(
-    values: Iterable[str],
-    field: FieldAttr,
-    registry: type[Record],
-    standardize: bool = False,
-    exclude: str | list | None = None,
-    **kwargs,
-):
-    """Standardize and inspect values using a registry."""
-    # inspect exclude values in the default instance
-    values = list(values)
-    include_validated = []
-    if exclude is not None:
-        exclude = [exclude] if isinstance(exclude, str) else exclude
-        exclude = [i for i in exclude if i in values]
-        if len(exclude) > 0:
-            # exclude values are validated without source and organism
-            inspect_result_exclude = registry.inspect(exclude, field=field, mute=True)
-            # if exclude values are validated, remove them from the values
-            values = [i for i in values if i not in inspect_result_exclude.validated]
-            include_validated = inspect_result_exclude.validated
-
-    if standardize:
-        if hasattr(registry, "standardize") and hasattr(
-            registry,
-            "synonyms",  # https://github.com/laminlabs/lamindb/issues/1685
-        ):
-            standardized_values = registry.standardize(
-                values, field=field, mute=True, **kwargs
-            )
-            values = standardized_values
-
-    inspect_result = registry.inspect(values, field=field, mute=True, **kwargs)
-    inspect_result._validated += include_validated
-    inspect_result._non_validated = [
-        i for i in inspect_result.non_validated if i not in include_validated
-    ]
-
-    return inspect_result
-
-
-def check_registry_organism(registry: Record, organism: str | None = None) -> dict:
-    """Check if a registry needs an organism and return the organism name."""
-    if hasattr(registry, "organism_id"):
-        import bionty as bt
-
-        if organism is None and bt.settings.organism is None:
-            raise ValueError(
-                f"{registry.__name__} registry requires an organism!\n"
-                "      → please pass an organism name via organism="
-            )
-        return {"organism": organism or bt.settings.organism.name}
-    return {}
-
-
-def validate_categories(
-    values: Iterable[str],
-    field: FieldAttr,
-    key: str,
-    using_key: str | None = None,
-    organism: str | None = None,
-    source: Record | None = None,
-    exclude: str | list | None = None,
-    standardize: bool = True,
-    validated_hint_print: str | None = None,
-) -> tuple[bool, list]:
-    """Validate ontology terms in a pandas series using LaminDB registries.
-
-    Args:
-        values: The values to validate.
-        field: The field attribute.
-        key: The key referencing the slot in the DataFrame.
-        using_key: A reference LaminDB instance.
-        organism: The organism name.
-        source: The source record.
-        exclude: Exclude specific values.
-        standardize: Standardize the values.
-        validated_hint_print: The hint to print for validated values.
-    """
-    from lamindb._from_values import _print_values
-    from lamindb.core._settings import settings
-
-    model_field = f"{field.field.model.__name__}.{field.field.name}"
-
-    def _log_mapping_info():
-        logger.indent = ""
-        logger.info(f"mapping {colors.italic(key)} on {colors.italic(model_field)}")
-        logger.indent = "   "
-
-    registry = field.field.model
-
-    kwargs = check_registry_organism(registry, organism)
-    kwargs.update({"source": source} if source else {})
-    kwargs_current = get_current_filter_kwargs(registry, kwargs)
-
-    # inspect the default instance
-    inspect_result = standardize_and_inspect(
-        values=values,
-        field=field,
-        registry=registry,
-        standardize=standardize,
-        exclude=exclude,
-        **kwargs_current,
-    )
-    non_validated = inspect_result.non_validated
-
-    # inspect the using instance
-    values_validated = []
-    if using_key is not None and using_key != "default" and non_validated:
-        registry_using = get_registry_instance(registry, using_key)
-        inspect_result = standardize_and_inspect(
-            values=non_validated,
-            field=field,
-            registry=registry_using,
-            standardize=standardize,
-            exclude=exclude,
-            **kwargs,
-        )
-        non_validated = inspect_result.non_validated
-        values_validated += inspect_result.validated
-
-    # inspect from public (bionty only)
-    if hasattr(registry, "public"):
-        verbosity = settings.verbosity
-        try:
-            settings.verbosity = "error"
-            public_records = registry.from_values(
-                non_validated,
-                field=field,
-                **kwargs_current,
-            )
-            values_validated += [getattr(r, field.field.name) for r in public_records]
-        finally:
-            settings.verbosity = verbosity
-
-    validated_hint_print = validated_hint_print or f".add_validated_from('{key}')"
-    n_validated = len(values_validated)
-    if n_validated > 0:
-        _log_mapping_info()
-        logger.warning(
-            f"found {colors.yellow(n_validated)} validated terms: "
-            f"{colors.yellow(values_validated)}\n      → save terms via "
-            f"{colors.yellow(validated_hint_print)}"
-        )
-
-    non_validated_hint_print = f".add_new_from('{key}')"
-    non_validated = [i for i in non_validated if i not in values_validated]
-    n_non_validated = len(non_validated)
-    if n_non_validated == 0:
-        if n_validated == 0:
-            logger.indent = ""
-            logger.success(f"{key} is validated against {colors.italic(model_field)}")
-            return True, []
-        else:
-            # validated values still need to be saved to the current instance
-            return False, []
-    else:
-        are = "are" if n_non_validated > 1 else "is"
-        print_values = _print_values(non_validated)
-        warning_message = (
-            f"{colors.red(f'{n_non_validated} terms')} {are} not validated: "
-            f"{colors.red(print_values)}\n      → fix typos, remove non-existent values, or save terms via "
-            f"{colors.red(non_validated_hint_print)}"
-        )
-        if logger.indent == "":
-            _log_mapping_info()
-        logger.warning(warning_message)
-        logger.indent = ""
-        return False, non_validated
-
-
-def validate_categories_in_df(
-    df: pd.DataFrame,
-    fields: dict[str, FieldAttr],
-    using_key: str | None = None,
-    sources: dict[str, Record] = None,
-    exclude: dict | None = None,
-    **kwargs,
-) -> tuple[bool, dict]:
-    """Validate categories in DataFrame columns using LaminDB registries."""
-    if not fields:
-        return True, {}
-
-    if sources is None:
-        sources = {}
-    validated = True
-    non_validated = {}
-    for key, field in fields.items():
-        is_val, non_val = validate_categories(
-            df[key],
-            field=field,
-            key=key,
-            using_key=using_key,
-            source=sources.get(key),
-            exclude=exclude.get(key) if exclude else None,
-            **kwargs,
-        )
-        validated &= is_val
-        if len(non_val) > 0:
-            non_validated[key] = non_val
-    return validated, non_validated
-
-
-def save_artifact(
-    data: pd.DataFrame | ad.AnnData | MuData,
-    fields: dict[str, FieldAttr] | dict[str, dict[str, FieldAttr]],
-    columns_field: FieldAttr | dict[str, FieldAttr],
-    description: str | None = None,
-    organism: str | None = None,
-    adata: ad.AnnData | None = None,
-    **kwargs,
-) -> Artifact:
-    """Save all metadata with an Artifact.
-
-    Args:
-        data: The DataFrame or AnnData object to save.
-        description: A description of the artifact.
-        fields: A dictionary mapping obs_column to registry_field.
-        columns_field: The registry field to validate variables index against.
-        organism: The organism name.
-        adata: The AnnData object to save, must be provided if data is a path.
-        kwargs: Additional keyword arguments to pass to the registry model.
-
-    Returns:
-        The saved Artifact.
-    """
-    from ._artifact import data_is_anndata
-
-    artifact = None
-    if data_is_anndata(data):
-        assert adata is not None  # noqa: S101
-        artifact = Artifact.from_anndata(data, description=description, **kwargs)
-        artifact.n_observations = adata.shape[0]
-        data = adata
-
-    elif isinstance(data, pd.DataFrame):
-        artifact = Artifact.from_df(data, description=description, **kwargs)
-    else:
-        try:
-            from mudata import MuData
-
-            if isinstance(data, MuData):
-                artifact = Artifact.from_mudata(data, description=description, **kwargs)
-                artifact.n_observations = data.n_obs
-        except ImportError:
-            pass
-    if artifact is None:
-        raise ValueError("data must be a DataFrame, AnnData or MuData object.")
-    artifact.save()
-
-    feature_kwargs = check_registry_organism(
-        (
-            list(columns_field.values())[0].field.model
-            if isinstance(columns_field, dict)
-            else columns_field.field.model
-        ),
-        organism,
-    )
-
-    if artifact._accessor == "DataFrame":
-        artifact.features._add_set_from_df(field=columns_field, **feature_kwargs)
-    elif artifact._accessor == "AnnData":
-        artifact.features._add_set_from_anndata(
-            var_field=columns_field, **feature_kwargs
-        )
-    elif artifact._accessor == "MuData":
-        artifact.features._add_set_from_mudata(
-            var_fields=columns_field, **feature_kwargs
-        )
-    else:
-        raise NotImplementedError
-
-    def _add_labels(data, artifact: Artifact, fields: dict[str, FieldAttr]):
-        features = Feature.lookup().dict()
-        for key, field in fields.items():
-            feature = features.get(key)
-            registry = field.field.model
-            filter_kwargs = check_registry_organism(registry, organism)
-            filter_kwargs_current = get_current_filter_kwargs(registry, filter_kwargs)
-            df = data if isinstance(data, pd.DataFrame) else data.obs
-            labels = registry.from_values(
-                df[key],
-                field=field,
-                **filter_kwargs_current,
-            )
-            artifact.labels.add(labels, feature)
-
-    if artifact._accessor == "MuData":
-        for modality, modality_fields in fields.items():
-            if modality == "obs":
-                _add_labels(data, artifact, modality_fields)
-            else:
-                _add_labels(data[modality], artifact, modality_fields)
-    else:
-        _add_labels(data, artifact, fields)
-
-    slug = ln_setup.settings.instance.slug
-    if ln_setup.settings.instance.is_remote:  # pragma: no cover
-        logger.important(f"go to https://lamin.ai/{slug}/artifact/{artifact.uid}")
-    return artifact
-
-
-def update_registry(
-    values: list[str],
-    field: FieldAttr,
-    key: str,
-    save_function: str = "add_new_from",
-    using_key: str | None = None,
-    validated_only: bool = True,
-    df: pd.DataFrame | None = None,
-    organism: str | None = None,
-    dtype: str | None = None,
-    source: Record | None = None,
-    standardize: bool = True,
-    warning: bool = True,
-    exclude: str | list | None = None,
-    **kwargs,
-) -> None:
-    """Save features or labels records in the default instance from the using_key instance.
-
-    Args:
-        values: A list of values to be saved as labels.
-        field: The FieldAttr object representing the field for which labels are being saved.
-        key: The name of the feature to save.
-        save_function: The name of the function to save the labels.
-        using_key: The name of the instance from which to transfer labels (if applicable).
-        validated_only: If True, only save validated labels.
-        df: A DataFrame to save labels from.
-        organism: The organism name.
-        dtype: The type of the feature.
-        source: The source record.
-        kwargs: Additional keyword arguments to pass to the registry model to create new records.
-    """
-    from lamindb._save import save as ln_save
-    from lamindb.core._settings import settings
-
-    registry = field.field.model
-    filter_kwargs = check_registry_organism(registry, organism)
-    filter_kwargs.update({"source": source} if source else {})
-
-    verbosity = settings.verbosity
-    try:
-        settings.verbosity = "error"
-
-        # save from public
-        filter_kwargs_current = get_current_filter_kwargs(registry, filter_kwargs)
-        existing_and_public_records = (
-            registry.from_values(
-                list(values),
-                field=field,
-                **filter_kwargs_current,
-            )
-            if values
-            else []
-        )
-
-        labels_saved: dict = {"from public": [], "without reference": []}
-
-        public_records = [r for r in existing_and_public_records if r._state.adding]
-        # here we check to only save the public records if they are from the specified source
-        # we check the uid because r.source and soruce can be from different instances
-        if source:
-            public_records = [r for r in public_records if r.source.uid == source.uid]
-        ln_save(public_records)
-        labels_saved["from public"] = [
-            getattr(r, field.field.name) for r in public_records
-        ]
-        non_public_labels = [i for i in values if i not in labels_saved["from public"]]
-
-        # inspect the default instance
-        inspect_result_current = standardize_and_inspect(
-            values=non_public_labels,
-            field=field,
-            registry=registry,
-            standardize=standardize,
-            exclude=exclude,
-            **filter_kwargs_current,
-        )
-        if not inspect_result_current.non_validated:
-            all_labels = registry.from_values(
-                inspect_result_current.validated,
-                field=field,
-                **filter_kwargs_current,
-            )
-            settings.verbosity = verbosity
-            return all_labels
-
-        # inspect the using_key instance
-        (
-            labels_saved[f"from {using_key}"],
-            non_validated_labels,
-        ) = update_registry_from_using_instance(
-            inspect_result_current.non_validated,
-            field=field,
-            using_key=using_key,
-            exclude=exclude,
-            **filter_kwargs,
-        )
-
-        labels_saved["without reference"] = [
-            i
-            for i in non_validated_labels
-            if i not in labels_saved[f"from {using_key}"]
-        ]
-
-        # save non-validated records
-        if not validated_only:
-            non_validated_records = []
-            if df is not None and registry == Feature:
-                non_validated_records = Feature.from_df(df)
-            else:
-                if "organism" in filter_kwargs:
-                    # make sure organism record is saved to the current instance
-                    filter_kwargs["organism"] = _save_organism(name=organism)
-                init_kwargs = {}
-                for value in labels_saved["without reference"]:
-                    init_kwargs[field.field.name] = value
-                    if registry == Feature:
-                        init_kwargs["dtype"] = "cat" if dtype is None else dtype
-                    non_validated_records.append(
-                        registry(
-                            **init_kwargs,
-                            **{k: v for k, v in filter_kwargs.items() if k != "source"},
-                            **{k: v for k, v in kwargs.items() if k != "sources"},
-                        )
-                    )
-            ln_save(non_validated_records)
-
-        # save parent labels for ulabels
-        if registry == ULabel and field.field.name == "name":
-            save_ulabels_with_parent(values, field=field, key=key)
-
-        # # get all records that are now validated in the current instance
-        # all_labels = registry.from_values(
-        #     inspect_result_current.validated + inspect_result_current.non_validated,
-        #     field=field,
-        #     **get_current_filter_kwargs(registry, filter_kwargs),
-        # )
-    finally:
-        settings.verbosity = verbosity
-
-    log_saved_labels(
-        labels_saved,
-        key=key,
-        save_function=save_function,
-        model_field=f"{registry.__name__}.{field.field.name}",
-        validated_only=validated_only,
-        warning=warning,
-    )
-
-    # return all_labels
-
-
-def log_saved_labels(
-    labels_saved: dict,
-    key: str,
-    save_function: str,
-    model_field: str,
-    validated_only: bool = True,
-    warning: bool = True,
-) -> None:
-    """Log the saved labels."""
-    from ._from_values import _print_values
-
-    model_field = colors.italic(model_field)
-    for k, labels in labels_saved.items():
-        if not labels:
-            continue
-
-        if k == "without reference" and validated_only:
-            msg = colors.yellow(
-                f"{len(labels)} non-validated values are not saved in {model_field}: {labels}!"
-            )
-            lookup_print = (
-                f"lookup().{key}" if key.isidentifier() else f".lookup()['{key}']"
-            )
-
-            hint = f".add_new_from('{key}')"
-            msg += f"\n      → to lookup values, use {lookup_print}"
-            msg += (
-                f"\n      → to save, run {colors.yellow(hint)}"
-                if save_function == "add_new_from"
-                else f"\n      → to save, run {colors.yellow(save_function)}"
-            )
-            if warning:
-                logger.warning(msg)
-            else:
-                logger.info(msg)
-        else:
-            k = "" if k == "without reference" else f"{colors.green(k)} "
-            # the term "transferred" stresses that this is always in the context of transferring
-            # labels from a public ontology or a different instance to the present instance
-            s = "s" if len(labels) > 1 else ""
-            logger.success(
-                f"added {len(labels)} record{s} {k}with {model_field} for {colors.italic(key)}: {_print_values(labels)}"
-            )
-
-
-def save_ulabels_with_parent(values: list[str], field: FieldAttr, key: str) -> None:
-    """Save a parent label for the given labels."""
-    registry = field.field.model
-    assert registry == ULabel  # noqa: S101
-    all_records = registry.from_values(list(values), field=field)
-    is_feature = registry.filter(name=f"is_{key}").one_or_none()
-    if is_feature is None:
-        is_feature = registry(name=f"is_{key}")
-        is_feature.save()
-    is_feature.children.add(*all_records)
-
-
-def update_registry_from_using_instance(
-    values: list[str],
-    field: FieldAttr,
-    using_key: str | None = None,
-    standardize: bool = False,
-    exclude: str | list | None = None,
-    **kwargs,
-) -> tuple[list[str], list[str]]:
-    """Save features or labels records from the using_key instance.
-
-    Args:
-        values: A list of values to be saved as labels.
-        field: The FieldAttr object representing the field for which labels are being saved.
-        using_key: The name of the instance from which to transfer labels (if applicable).
-        standardize: Whether to also standardize the values.
-        kwargs: Additional keyword arguments to pass to the registry model.
-
-    Returns:
-        A tuple containing the list of saved labels and the list of non-saved labels.
-    """
-    labels_saved = []
-    not_saved = values
-
-    if using_key is not None and using_key != "default":
-        registry_using = get_registry_instance(field.field.model, using_key)
-
-        inspect_result_using = standardize_and_inspect(
-            values=values,
-            field=field,
-            registry=registry_using,
-            standardize=standardize,
-            exclude=exclude,
-            **kwargs,
-        )
-        labels_using = registry_using.filter(
-            **{f"{field.field.name}__in": inspect_result_using.validated}
-        ).all()
-        for label_using in labels_using:
-            label_using.save()
-            labels_saved.append(getattr(label_using, field.field.name))
-        not_saved = inspect_result_using.non_validated
-
-    return labels_saved, not_saved
-
-
-def _save_organism(name: str):  # pragma: no cover
-    """Save an organism record."""
-    import bionty as bt
-
-    organism = bt.Organism.filter(name=name).one_or_none()
-    if organism is None:
-        organism = bt.Organism.from_source(name=name)
-        if organism is None:
-            raise ValueError(
-                f"Organism '{name}' not found\n"
-                f"      → please save it: bt.Organism(name='{name}').save()"
-            )
-        organism.save()
-    return organism
-
-
-Curate = Curator  # backward compat
+from __future__ import annotations
+
+import copy
+from typing import TYPE_CHECKING, Iterable
+
+import anndata as ad
+import lamindb_setup as ln_setup
+import pandas as pd
+from lamin_utils import colors, logger
+from lamindb_setup.core._docs import doc_args
+from lnschema_core import (
+    Artifact,
+    Feature,
+    Record,
+    Run,
+    ULabel,
+)
+
+from .core.exceptions import ValidationError
+
+if TYPE_CHECKING:
+    from lamindb_setup.core.types import UPathStr
+    from lnschema_core.types import FieldAttr
+    from mudata import MuData
+
+
+class CurateLookup:
+    """Lookup categories from the reference instance."""
+
+    def __init__(
+        self,
+        categoricals: dict[str, FieldAttr],
+        slots: dict[str, FieldAttr] = None,
+        using_key: str | None = None,
+    ) -> None:
+        if slots is None:
+            slots = {}
+        self._fields = {**categoricals, **slots}
+        self._using_key = None if using_key == "default" else using_key
+        self._using_key_name = self._using_key or ln_setup.settings.instance.slug
+        debug_message = (
+            f"Lookup objects from the " f"{colors.italic(self._using_key_name)}"
+        )
+        logger.debug(debug_message)
+
+    def __getattr__(self, name):
+        if name in self._fields:
+            registry = self._fields[name].field.model
+            if self._using_key == "public":
+                return registry.public().lookup()
+            else:
+                return get_registry_instance(registry, self._using_key).lookup()
+        raise AttributeError(
+            f"'{self.__class__.__name__}' object has no attribute '{name}'"
+        )
+
+    def __getitem__(self, name):
+        if name in self._fields:
+            registry = self._fields[name].field.model
+            if self._using_key == "public":
+                return registry.public().lookup()
+            else:
+                return get_registry_instance(registry, self._using_key).lookup()
+        raise AttributeError(
+            f"'{self.__class__.__name__}' object has no attribute '{name}'"
+        )
+
+    def __repr__(self) -> str:
+        if len(self._fields) > 0:
+            getattr_keys = "\n ".join(
+                [f".{key}" for key in self._fields if key.isidentifier()]
+            )
+            getitem_keys = "\n ".join(
+                [str([key]) for key in self._fields if not key.isidentifier()]
+            )
+            return (
+                f"Lookup objects from the {colors.italic(self._using_key_name)}:\n "
+                f"{colors.green(getattr_keys)}\n "
+                f"{colors.green(getitem_keys)}\n\n"
+                "Example:\n    → categories = validator.lookup().cell_type\n"
+                "    → categories.alveolar_type_1_fibroblast_cell"
+            )
+        else:  # pragma: no cover
+            return colors.warning("No fields are found!")
+
+
+class BaseCurator:
+    """Curate a dataset."""
+
+    def validate(self) -> bool:
+        """Validate dataset.
+
+        Returns:
+            Boolean indicating whether the dataset is validated.
+        """
+        pass
+
+    def save_artifact(self, description: str | None = None, **kwargs) -> Artifact:
+        """Save the dataset as artifact.
+
+        Args:
+            description: Description of the DataFrame object.
+            **kwargs: Object level metadata.
+
+        Returns:
+            A saved artifact record.
+        """
+        pass
+
+
+class DataFrameCurator(BaseCurator):
+    """Curation flow for a DataFrame object.
+
+    See also :class:`~lamindb.Curator`.
+
+    Args:
+        df: The DataFrame object to curate.
+        columns: The field attribute for the feature column.
+        categoricals: A dictionary mapping column names to registry_field.
+        using_key: The reference instance containing registries to validate against.
+        verbosity: The verbosity level.
+        organism: The organism name.
+        sources: A dictionary mapping column names to Source records.
+        exclude: A dictionary mapping column names to values to exclude.
+
+    Examples:
+        >>> import bionty as bt
+        >>> curate = ln.Curator.from_df(
+        ...     df,
+        ...     categoricals={
+        ...         "cell_type_ontology_id": bt.CellType.ontology_id,
+        ...         "donor_id": ln.ULabel.name
+        ...     }
+        ... )
+    """
+
+    def __init__(
+        self,
+        df: pd.DataFrame,
+        columns: FieldAttr = Feature.name,
+        categoricals: dict[str, FieldAttr] | None = None,
+        using_key: str | None = None,
+        verbosity: str = "hint",
+        organism: str | None = None,
+        sources: dict[str, Record] | None = None,
+        exclude: dict | None = None,
+        check_valid_keys: bool = True,
+    ) -> None:
+        from lamindb.core._settings import settings
+
+        self._df = df
+        self._fields = categoricals or {}
+        self._columns_field = columns
+        self._using_key = using_key
+        settings.verbosity = verbosity
+        self._artifact = None
+        self._collection = None
+        self._validated = False
+        self._kwargs = {"organism": organism} if organism else {}
+        if sources is None:
+            sources = {}
+        self._sources = sources
+        if exclude is None:
+            exclude = {}
+        self._exclude = exclude
+        self._non_validated = None
+        if check_valid_keys:
+            self._check_valid_keys()
+        self._save_columns()
+
+    @property
+    def non_validated(self) -> list:
+        """Return the non-validated features and labels."""
+        if self._non_validated is None:
+            raise ValueError("Please run validate() first!")
+        return self._non_validated
+
+    @property
+    def fields(self) -> dict:
+        """Return the columns fields to validate against."""
+        return self._fields
+
+    def lookup(self, using_key: str | None = None) -> CurateLookup:
+        """Lookup categories.
+
+        Args:
+            using_key: The instance where the lookup is performed.
+                if None (default), the lookup is performed on the instance specified in "using_key" parameter of the validator.
+                if "public", the lookup is performed on the public reference.
+        """
+        return CurateLookup(
+            categoricals=self._fields,
+            slots={"columns": self._columns_field},
+            using_key=using_key or self._using_key,
+        )
+
+    def _check_valid_keys(self, extra: set = None) -> None:
+        if extra is None:
+            extra = set()
+        for name, d in {
+            "categoricals": self._fields,
+            "sources": self._sources,
+            "exclude": self._exclude,
+        }.items():
+            if not isinstance(d, dict):
+                raise TypeError(f"{name} must be a dictionary!")
+            valid_keys = set(self._df.columns) | {"columns"} | extra
+            nonval_keys = [key for key in d.keys() if key not in valid_keys]
+            if len(nonval_keys) > 0:
+                raise ValueError(
+                    f"the following keys passed to {name} are not allowed: {nonval_keys}"
+                )
+
+    def _save_columns(self, validated_only: bool = True, **kwargs) -> None:
+        """Save column name records."""
+        # Always save features specified as the fields keys
+        update_registry(
+            values=list(self.fields.keys()),
+            field=self._columns_field,
+            key="columns",
+            save_function="add_new_from_columns",
+            using_key=self._using_key,
+            validated_only=False,
+            source=self._sources.get("columns"),
+            exclude=self._exclude.get("columns"),
+            **kwargs,
+        )
+
+        # Save the rest of the columns based on validated_only
+        additional_columns = set(self._df.columns) - set(self.fields.keys())
+        if additional_columns:
+            update_registry(
+                values=list(additional_columns),
+                field=self._columns_field,
+                key="columns",
+                save_function="add_new_from_columns",
+                using_key=self._using_key,
+                validated_only=validated_only,
+                df=self._df,  # Get the Feature type from df
+                source=self._sources.get("columns"),
+                exclude=self._exclude.get("columns"),
+                warning=False,  # Do not warn about missing columns, just an info message
+                **kwargs,
+            )
+
+    def add_validated_from(self, key: str, organism: str | None = None):
+        """Add validated categories.
+
+        Args:
+            key: The key referencing the slot in the DataFrame.
+            organism: The organism name.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        self._update_registry(key, validated_only=True, **self._kwargs)
+
+    def add_new_from(self, key: str, organism: str | None = None, **kwargs):
+        """Add validated & new categories.
+
+        Args:
+            key: The key referencing the slot in the DataFrame from which to draw terms.
+            organism: The organism name.
+            **kwargs: Additional keyword arguments to pass to the registry model.
+        """
+        if len(kwargs) > 0 and key == "all":
+            raise ValueError("Cannot pass additional arguments to 'all' key!")
+        self._kwargs.update({"organism": organism} if organism else {})
+        self._update_registry(key, validated_only=False, **self._kwargs, **kwargs)
+
+    def add_new_from_columns(self, organism: str | None = None, **kwargs):
+        """Add validated & new column names to its registry.
+
+        Args:
+            organism: The organism name.
+            **kwargs: Additional keyword arguments to pass to the registry model.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        self._save_columns(validated_only=False, **self._kwargs, **kwargs)
+
+    def _update_registry(self, categorical: str, validated_only: bool = True, **kwargs):
+        if categorical == "all":
+            self._update_registry_all(validated_only=validated_only, **kwargs)
+        elif categorical == "columns":
+            self._save_columns(validated_only=validated_only, **kwargs)
+        else:
+            if categorical not in self.fields:
+                raise ValueError(f"Feature {categorical} is not part of the fields!")
+            update_registry(
+                values=self._df[categorical].unique().tolist(),
+                field=self.fields[categorical],
+                key=categorical,
+                using_key=self._using_key,
+                validated_only=validated_only,
+                source=self._sources.get(categorical),
+                exclude=self._exclude.get(categorical),
+                **kwargs,
+            )
+
+    def _update_registry_all(self, validated_only: bool = True, **kwargs):
+        """Save labels for all features."""
+        for name in self.fields.keys():
+            logger.info(f"saving labels for '{name}'")
+            self._update_registry(name, validated_only=validated_only, **kwargs)
+
+    def validate(self, organism: str | None = None) -> bool:
+        """Validate variables and categorical observations.
+
+        Args:
+            organism: The organism name.
+
+        Returns:
+            Whether the DataFrame is validated.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        self._validated, self._non_validated = validate_categories_in_df(  # type: ignore
+            self._df,
+            fields=self.fields,
+            using_key=self._using_key,
+            sources=self._sources,
+            exclude=self._exclude,
+            **self._kwargs,
+        )
+        return self._validated
+
+    def save_artifact(self, description: str | None = None, **kwargs) -> Artifact:
+        """Save the validated DataFrame and metadata.
+
+        Args:
+            description: Description of the DataFrame object.
+            **kwargs: Object level metadata.
+
+        Returns:
+            A saved artifact record.
+        """
+        from lamindb.core._settings import settings
+
+        if not self._validated:
+            self.validate()
+            if not self._validated:
+                raise ValidationError("Dataset does not validate. Please curate.")
+
+        # Make sure all labels are saved in the current instance
+        verbosity = settings.verbosity
+        try:
+            settings.verbosity = "warning"
+            # save all validated records to the current instance
+            self.add_validated_from("all")
+
+            self._artifact = save_artifact(
+                self._df,
+                description=description,
+                fields=self.fields,
+                columns_field=self._columns_field,
+                **kwargs,
+                **self._kwargs,
+            )
+        finally:
+            settings.verbosity = verbosity
+
+        return self._artifact
+
+    def clean_up_failed_runs(self):
+        """Clean up previous failed runs that don't save any outputs."""
+        from lamindb.core._context import context
+
+        if context.run is not None:
+            Run.filter(transform=context.run.transform, output_artifacts=None).exclude(
+                uid=context.run.uid
+            ).delete()
+
+
+class AnnDataCurator(DataFrameCurator):
+    """Curation flow for ``AnnData``.
+
+    See also :class:`~lamindb.Curator`.
+
+    Note that if genes are removed from the AnnData object, the object should be recreated using :meth:`~lamindb.Curator.from_anndata`.
+
+    See :doc:`docs:cellxgene-curate` for instructions on how to curate against a specific cellxgene schema version.
+
+    Args:
+        data: The AnnData object or an AnnData-like path.
+        var_index: The registry field for mapping the ``.var`` index.
+        categoricals: A dictionary mapping ``.obs.columns`` to a registry field.
+        using_key: A reference LaminDB instance.
+        verbosity: The verbosity level.
+        organism: The organism name.
+        sources: A dictionary mapping ``.obs.columns`` to Source records.
+        exclude: A dictionary mapping column names to values to exclude.
+
+    Examples:
+        >>> import bionty as bt
+        >>> curate = ln.Curator.from_anndata(
+        ...     adata,
+        ...     var_index=bt.Gene.ensembl_gene_id,
+        ...     categoricals={
+        ...         "cell_type_ontology_id": bt.CellType.ontology_id,
+        ...         "donor_id": ln.ULabel.name
+        ...     },
+        ...     organism="human",
+        ... )
+    """
+
+    def __init__(
+        self,
+        data: ad.AnnData | UPathStr,
+        var_index: FieldAttr,
+        categoricals: dict[str, FieldAttr] | None = None,
+        obs_columns: FieldAttr = Feature.name,
+        using_key: str = "default",
+        verbosity: str = "hint",
+        organism: str | None = None,
+        sources: dict[str, Record] | None = None,
+        exclude: dict | None = None,
+    ) -> None:
+        from lamindb_setup.core import upath
+
+        from ._artifact import data_is_anndata
+
+        if sources is None:
+            sources = {}
+        if not data_is_anndata(data):
+            raise ValueError(
+                "data has to be an AnnData object or a path to AnnData-like"
+            )
+        if isinstance(data, ad.AnnData):
+            self._adata = data
+        else:  # pragma: no cover
+            from lamindb.core.storage._backed_access import backed_access
+
+            self._adata = backed_access(upath.create_path(data))
+
+        self._data = data
+        self._var_field = var_index
+        super().__init__(
+            df=self._adata.obs,
+            categoricals=categoricals,
+            columns=obs_columns,
+            using_key=using_key,
+            verbosity=verbosity,
+            organism=organism,
+            sources=sources,
+            exclude=exclude,
+            check_valid_keys=False,
+        )
+        self._obs_fields = categoricals or {}
+        self._check_valid_keys(extra={"var_index"})
+
+    @property
+    def var_index(self) -> FieldAttr:
+        """Return the registry field to validate variables index against."""
+        return self._var_field
+
+    @property
+    def categoricals(self) -> dict:
+        """Return the obs fields to validate against."""
+        return self._obs_fields
+
+    def lookup(self, using_key: str | None = None) -> CurateLookup:
+        """Lookup categories.
+
+        Args:
+            using_key: The instance where the lookup is performed.
+                if None (default), the lookup is performed on the instance specified in "using" parameter of the validator.
+                if "public", the lookup is performed on the public reference.
+        """
+        return CurateLookup(
+            categoricals=self._obs_fields,
+            slots={"columns": self._columns_field, "var_index": self._var_field},
+            using_key=using_key or self._using_key,
+        )
+
+    def _save_from_var_index(
+        self, validated_only: bool = True, organism: str | None = None
+    ):
+        """Save variable records."""
+        update_registry(
+            values=list(self._adata.var.index),
+            field=self.var_index,
+            key="var_index",
+            save_function="add_new_from_var_index",
+            using_key=self._using_key,
+            validated_only=validated_only,
+            organism=organism,
+            source=self._sources.get("var_index"),
+            exclude=self._exclude.get("var_index"),
+        )
+
+    def _update_registry_all(self, validated_only: bool = True, **kwargs):
+        """Save labels for all features."""
+        for name in self.fields.keys():
+            logger.info(f"saving labels for '{name}'")
+            if name == "var_index":
+                self._save_from_var_index(validated_only=validated_only, **kwargs)
+            else:
+                self._update_registry(name, validated_only=validated_only, **kwargs)
+
+    def add_new_from_var_index(self, organism: str | None = None, **kwargs):
+        """Update variable records.
+
+        Args:
+            organism: The organism name.
+            **kwargs: Additional keyword arguments to pass to the registry model.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        self._save_from_var_index(validated_only=False, **self._kwargs, **kwargs)
+
+    def add_validated_from_var_index(self, organism: str | None = None):
+        """Add validated variable records.
+
+        Args:
+            organism: The organism name.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        self._save_from_var_index(validated_only=True, **self._kwargs)
+
+    def validate(self, organism: str | None = None) -> bool:
+        """Validate categories.
+
+        Args:
+            organism: The organism name.
+
+        Returns:
+            Whether the AnnData object is validated.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        if self._using_key is not None and self._using_key != "default":
+            logger.important(
+                f"validating metadata using registries of instance {colors.italic(self._using_key)}"
+            )
+
+        validated_var, non_validated_var = validate_categories(
+            self._adata.var.index,
+            field=self._var_field,
+            key="var_index",
+            using_key=self._using_key,
+            source=self._sources.get("var_index"),
+            validated_hint_print=".add_validated_from_var_index()",
+            exclude=self._exclude.get("var_index"),
+            **self._kwargs,  # type: ignore
+        )
+        validated_obs, non_validated_obs = validate_categories_in_df(
+            self._adata.obs,
+            fields=self.categoricals,
+            using_key=self._using_key,
+            sources=self._sources,
+            exclude=self._exclude,
+            **self._kwargs,
+        )
+        self._non_validated = non_validated_obs  # type: ignore
+        if len(non_validated_var) > 0:
+            self._non_validated["var_index"] = non_validated_var  # type: ignore
+        self._validated = validated_var and validated_obs
+        return self._validated
+
+    def save_artifact(self, description: str | None = None, **kwargs) -> Artifact:
+        """Save the validated ``AnnData`` and metadata.
+
+        Args:
+            description: Description of the ``AnnData`` object.
+            **kwargs: Object level metadata.
+
+        Returns:
+            A saved artifact record.
+        """
+        if not self._validated:
+            self.validate()
+            if not self._validated:
+                raise ValidationError("Dataset does not validate. Please curate.")
+
+        self._artifact = save_artifact(
+            self._data,
+            adata=self._adata,
+            description=description,
+            columns_field=self.var_index,
+            fields=self.categoricals,
+            **self._kwargs,
+            **kwargs,
+        )
+        return self._artifact
+
+
+class MuDataCurator:
+    """Curation flow for a ``MuData`` object.
+
+    See also :class:`~lamindb.Curator`.
+
+    Note that if genes or other measurements are removed from the MuData object,
+    the object should be recreated using :meth:`~lamindb.Curator.from_mudata`.
+
+    Args:
+        mdata: The MuData object to curate.
+        var_index: The registry field for mapping the ``.var`` index for each modality.
+            For example:
+            ``{"modality_1": bt.Gene.ensembl_gene_id, "modality_2": ln.CellMarker.name}``
+        categoricals: A dictionary mapping ``.obs.columns`` to a registry field.
+            Use modality keys to specify categoricals for MuData slots such as `"rna:cell_type": bt.CellType.name"`.
+        using_key: A reference LaminDB instance.
+        verbosity: The verbosity level.
+        organism: The organism name.
+        sources: A dictionary mapping ``.obs.columns`` to Source records.
+        exclude: A dictionary mapping column names to values to exclude.
+
+    Examples:
+        >>> import bionty as bt
+        >>> curate = ln.Curator.from_mudata(
+        ...     mdata,
+        ...     var_index={
+        ...         "rna": bt.Gene.ensembl_gene_id,
+        ...         "adt": ln.CellMarker.name
+        ...     },
+        ...     categoricals={
+        ...         "cell_type_ontology_id": bt.CellType.ontology_id,
+        ...         "donor_id": ln.ULabel.name
+        ...     },
+        ...     organism="human",
+        ... )
+    """
+
+    def __init__(
+        self,
+        mdata: MuData,
+        var_index: dict[str, dict[str, FieldAttr]],
+        categoricals: dict[str, FieldAttr] | None = None,
+        using_key: str = "default",
+        verbosity: str = "hint",
+        organism: str | None = None,
+        sources: dict[str, Record] | None = None,
+        exclude: dict | None = None,
+    ) -> None:
+        if sources is None:
+            sources = {}
+        self._sources = sources
+        if exclude is None:
+            exclude = {}
+        self._exclude = exclude
+        self._mdata = mdata
+        self._kwargs = {"organism": organism} if organism else {}
+        self._var_fields = var_index
+        self._verify_modality(self._var_fields.keys())
+        self._obs_fields = self._parse_categoricals(categoricals)
+        self._modalities = set(self._var_fields.keys()) | set(self._obs_fields.keys())
+        self._using_key = using_key
+        self._verbosity = verbosity
+        self._df_annotators = {
+            modality: DataFrameCurator(
+                df=mdata[modality].obs if modality != "obs" else mdata.obs,
+                categoricals=self._obs_fields.get(modality, {}),
+                using_key=using_key,
+                verbosity=verbosity,
+                sources=self._sources.get(modality),
+                exclude=self._exclude.get(modality),
+                check_valid_keys=False,
+                **self._kwargs,
+            )
+            for modality in self._modalities
+        }
+        for modality in self._var_fields.keys():
+            self._save_from_var_index_modality(
+                modality=modality, validated_only=True, **self._kwargs
+            )
+
+    @property
+    def var_index(self) -> FieldAttr:
+        """Return the registry field to validate variables index against."""
+        return self._var_fields
+
+    @property
+    def categoricals(self) -> dict:
+        """Return the obs fields to validate against."""
+        return self._obs_fields
+
+    def _verify_modality(self, modalities: Iterable[str]):
+        """Verify the modality exists."""
+        for modality in modalities:
+            if modality not in self._mdata.mod.keys():
+                raise ValueError(f"modality '{modality}' does not exist!")
+
+    def _save_from_var_index_modality(
+        self, modality: str, validated_only: bool = True, **kwargs
+    ):
+        """Save variable records."""
+        update_registry(
+            values=list(self._mdata[modality].var.index),
+            field=self._var_fields[modality],
+            key="var_index",
+            save_function="add_new_from_var_index",
+            using_key=self._using_key,
+            validated_only=validated_only,
+            dtype="number",
+            source=self._sources.get(modality, {}).get("var_index"),
+            exclude=self._exclude.get(modality, {}).get("var_index"),
+            **kwargs,
+        )
+
+    def _parse_categoricals(self, categoricals: dict[str, FieldAttr]) -> dict:
+        """Parse the categorical fields."""
+        prefixes = {f"{k}:" for k in self._mdata.mod.keys()}
+        obs_fields: dict[str, dict[str, FieldAttr]] = {}
+        for k, v in categoricals.items():
+            if k not in self._mdata.obs.columns:
+                raise ValueError(f"column '{k}' does not exist in mdata.obs!")
+            if any(k.startswith(prefix) for prefix in prefixes):
+                modality, col = k.split(":")[0], k.split(":")[1]
+                if modality not in obs_fields.keys():
+                    obs_fields[modality] = {}
+                obs_fields[modality][col] = v
+            else:
+                if "obs" not in obs_fields.keys():
+                    obs_fields["obs"] = {}
+                obs_fields["obs"][k] = v
+        return obs_fields
+
+    def lookup(self, using_key: str | None = None) -> CurateLookup:
+        """Lookup categories.
+
+        Args:
+            using_key: The instance where the lookup is performed.
+                if None (default), the lookup is performed on the instance specified in "using_key" parameter of the validator.
+                if "public", the lookup is performed on the public reference.
+        """
+        return CurateLookup(
+            categoricals=self._obs_fields,
+            slots={
+                **self._obs_fields,
+                **{f"{k}_var_index": v for k, v in self._var_fields.items()},
+            },
+            using_key=using_key or self._using_key,
+        )
+
+    def add_new_from_columns(
+        self,
+        modality: str,
+        column_names: list[str] | None = None,
+        organism: str | None = None,
+        **kwargs,
+    ):
+        """Update columns records.
+
+        Args:
+            modality: The modality name.
+            column_names: The column names to save.
+            organism: The organism name.
+            **kwargs: Additional keyword arguments to pass to the registry model.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        values = column_names or self._mdata[modality].obs.columns
+        update_registry(
+            values=list(values),
+            field=Feature.name,
+            key=f"{modality} obs columns",
+            using_key=self._using_key,
+            validated_only=False,
+            df=self._mdata[modality].obs,
+            source=self._sources.get(modality, {}).get("columns"),
+            exclude=self._exclude.get(modality, {}).get("columns"),
+            **self._kwargs,  # type: ignore
+            **kwargs,
+        )
+
+    def add_new_from_var_index(
+        self, modality: str, organism: str | None = None, **kwargs
+    ):
+        """Update variable records.
+
+        Args:
+            modality: The modality name.
+            organism: The organism name.
+            **kwargs: Additional keyword arguments to pass to the registry model.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        self._save_from_var_index_modality(
+            modality=modality, validated_only=False, **self._kwargs, **kwargs
+        )
+
+    def add_validated_from_var_index(self, modality: str, organism: str | None = None):
+        """Add validated variable records.
+
+        Args:
+            modality: The modality name.
+            organism: The organism name.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        self._save_from_var_index_modality(
+            modality=modality, validated_only=True, **self._kwargs
+        )
+
+    def add_validated_from(
+        self, key: str, modality: str | None = None, organism: str | None = None
+    ):
+        """Add validated categories.
+
+        Args:
+            key: The key referencing the slot in the DataFrame.
+            modality: The modality name.
+            organism: The organism name.
+        """
+        self._kwargs.update({"organism": organism} if organism else {})
+        modality = modality or "obs"
+        if modality in self._df_annotators:
+            df_annotator = self._df_annotators[modality]
+            df_annotator.add_validated_from(key=key, **self._kwargs)
+
+    def add_new_from(
+        self,
+        key: str,
+        modality: str | None = None,
+        organism: str | None = None,
+        **kwargs,
+    ):
+        """Add validated & new categories.
+
+        Args:
+            key: The key referencing the slot in the DataFrame.
+            modality: The modality name.
+            organism: The organism name.
+            **kwargs: Additional keyword arguments to pass to the registry model.
+        """
+        if len(kwargs) > 0 and key == "all":
+            raise ValueError("Cannot pass additional arguments to 'all' key!")
+        self._kwargs.update({"organism": organism} if organism else {})
+        modality = modality or "obs"
+        if modality in self._df_annotators:
+            df_annotator = self._df_annotators[modality]
+            df_annotator.add_new_from(key=key, **self._kwargs, **kwargs)
+
+    def validate(self, organism: str | None = None) -> bool:
+        """Validate categories."""
+        self._kwargs.update({"organism": organism} if organism else {})
+        if self._using_key is not None and self._using_key != "default":
+            logger.important(
+                f"validating metadata using registries of instance {colors.italic(self._using_key)}"
+            )
+        validated_var = True
+        non_validated_var_modality = {}
+        for modality, var_field in self._var_fields.items():
+            is_validated_var, non_validated_var = validate_categories(
+                self._mdata[modality].var.index,
+                field=var_field,
+                key=f"{modality}_var_index",
+                using_key=self._using_key,
+                source=self._sources.get(modality, {}).get("var_index"),
+                exclude=self._exclude.get(modality, {}).get("var_index"),
+                **self._kwargs,  # type: ignore
+            )
+            validated_var &= is_validated_var
+            if len(non_validated_var) > 0:
+                non_validated_var_modality[modality] = non_validated_var
+
+        validated_obs = True
+        non_validated_obs_modality = {}
+        for modality, fields in self._obs_fields.items():
+            if modality == "obs":
+                obs = self._mdata.obs
+            else:
+                obs = self._mdata[modality].obs
+            is_validated_obs, non_validated_obs = validate_categories_in_df(
+                obs,
+                fields=fields,
+                using_key=self._using_key,
+                sources=self._sources.get(modality),
+                exclude=self._exclude.get(modality),
+                **self._kwargs,
+            )
+            validated_obs &= is_validated_obs
+            non_validated_obs_modality[modality] = non_validated_obs
+            if modality in non_validated_var_modality:
+                non_validated_obs_modality[modality]["var_index"] = (
+                    non_validated_var_modality[modality]
+                )
+            if len(non_validated_obs_modality[modality]) > 0:
+                self._non_validated = non_validated_obs_modality[modality]
+        self._validated = validated_var and validated_obs
+        return self._validated
+
+    def save_artifact(self, description: str | None = None, **kwargs) -> Artifact:
+        """Save the validated ``MuData`` and metadata.
+
+        Args:
+            description: Description of the ``MuData`` object.
+            **kwargs: Object level metadata.
+
+        Returns:
+            A saved artifact record.
+        """
+        if not self._validated:
+            raise ValidationError("Please run `validate()` first!")
+
+        self._artifact = save_artifact(
+            self._mdata,
+            description=description,
+            columns_field=self.var_index,
+            fields=self.categoricals,
+            **self._kwargs,
+            **kwargs,
+        )
+        return self._artifact
+
+
+class Curator(BaseCurator):
+    """Dataset curator.
+
+    Data curation entails accurately labeling datasets with standardized metadata
+    to facilitate data integration, interpretation and analysis.
+
+    The curation flow has several steps:
+
+    1. Instantiate `Curator` from one of the following dataset objects:
+
+    - :meth:`~lamindb.Curator.from_df`
+    - :meth:`~lamindb.Curator.from_anndata`
+    - :meth:`~lamindb.Curator.from_mudata`
+
+    During object creation, any passed categoricals found in the object will be saved.
+
+    2. Run :meth:`~lamindb.core.DataFrameCurator.validate` to check the data against the defined criteria. This method identifies:
+
+    - Values that can successfully validated and already exist in the registry.
+    - Values which are new and not yet validated or potentially problematic values.
+
+    3. Determine how to handle validated and non-validated values:
+
+    - Validated values not yet in the registry can be automatically registered using :meth:`~lamindb.core.DataFrameCurator.add_validated_from`.
+    - Valid and new values can be registered using :meth:`~lamindb.core.DataFrameCurator.add_new_from`.
+    - All unvalidated values can be accessed using :meth:`~lamindb.core.DataFrameCurator.non_validated` and subsequently removed from the object at hand.
+    """
+
+    @classmethod
+    @doc_args(DataFrameCurator.__doc__)
+    def from_df(
+        cls,
+        df: pd.DataFrame,
+        categoricals: dict[str, FieldAttr] | None = None,
+        columns: FieldAttr = Feature.name,
+        using_key: str | None = None,
+        verbosity: str = "hint",
+        organism: str | None = None,
+    ) -> DataFrameCurator:
+        """{}"""  # noqa: D415
+        return DataFrameCurator(
+            df=df,
+            categoricals=categoricals,
+            columns=columns,
+            using_key=using_key,
+            verbosity=verbosity,
+            organism=organism,
+        )
+
+    @classmethod
+    @doc_args(AnnDataCurator.__doc__)
+    def from_anndata(
+        cls,
+        data: ad.AnnData | UPathStr,
+        var_index: FieldAttr,
+        categoricals: dict[str, FieldAttr] | None = None,
+        obs_columns: FieldAttr = Feature.name,
+        using_key: str = "default",
+        verbosity: str = "hint",
+        organism: str | None = None,
+        sources: dict[str, Record] | None = None,
+    ) -> AnnDataCurator:
+        """{}"""  # noqa: D415
+        return AnnDataCurator(
+            data=data,
+            var_index=var_index,
+            categoricals=categoricals,
+            obs_columns=obs_columns,
+            using_key=using_key,
+            verbosity=verbosity,
+            organism=organism,
+            sources=sources,
+        )
+
+    @classmethod
+    @doc_args(MuDataCurator.__doc__)
+    def from_mudata(
+        cls,
+        mdata: MuData,
+        var_index: dict[str, dict[str, FieldAttr]],
+        categoricals: dict[str, FieldAttr] | None = None,
+        using_key: str = "default",
+        verbosity: str = "hint",
+        organism: str | None = None,
+    ) -> MuDataCurator:
+        """{}"""  # noqa: D415
+        return MuDataCurator(
+            mdata=mdata,
+            var_index=var_index,
+            categoricals=categoricals,
+            using_key=using_key,
+            verbosity=verbosity,
+            organism=organism,
+        )
+
+
+def get_registry_instance(registry: Record, using_key: str | None = None) -> Record:
+    """Get a registry instance using a specific instance."""
+    if using_key is not None and using_key != "default":
+        return registry.using(using_key)
+    return registry
+
+
+def get_current_filter_kwargs(registry: type[Record], kwargs: dict) -> dict:
+    """Make sure the source and organism are saved in the same database as the registry."""
+    from lamindb.core._settings import settings
+
+    db = registry.filter().db
+    source = kwargs.get("source")
+    organism = kwargs.get("organism")
+    filter_kwargs = kwargs.copy()
+    try:
+        verbosity = settings.verbosity
+        settings.verbosity = "error"
+        if isinstance(organism, Record) and organism._state.db != "default":
+            if db is None or db == "default":
+                organism_default = copy.copy(organism)
+                # save the organism record in the default database
+                organism_default.save()
+                filter_kwargs["organism"] = organism_default
+        if isinstance(source, Record) and source._state.db != "default":
+            if db is None or db == "default":
+                source_default = copy.copy(source)
+                # save the source record in the default database
+                source_default.save()
+                filter_kwargs["source"] = source_default
+    finally:
+        settings.verbosity = verbosity
+    return filter_kwargs
+
+
+def standardize_and_inspect(
+    values: Iterable[str],
+    field: FieldAttr,
+    registry: type[Record],
+    standardize: bool = False,
+    exclude: str | list | None = None,
+    **kwargs,
+):
+    """Standardize and inspect values using a registry."""
+    # inspect exclude values in the default instance
+    values = list(values)
+    include_validated = []
+    if exclude is not None:
+        exclude = [exclude] if isinstance(exclude, str) else exclude
+        exclude = [i for i in exclude if i in values]
+        if len(exclude) > 0:
+            # exclude values are validated without source and organism
+            inspect_result_exclude = registry.inspect(exclude, field=field, mute=True)
+            # if exclude values are validated, remove them from the values
+            values = [i for i in values if i not in inspect_result_exclude.validated]
+            include_validated = inspect_result_exclude.validated
+
+    if standardize:
+        if hasattr(registry, "standardize") and hasattr(
+            registry,
+            "synonyms",  # https://github.com/laminlabs/lamindb/issues/1685
+        ):
+            standardized_values = registry.standardize(
+                values, field=field, mute=True, **kwargs
+            )
+            values = standardized_values
+
+    inspect_result = registry.inspect(values, field=field, mute=True, **kwargs)
+    inspect_result._validated += include_validated
+    inspect_result._non_validated = [
+        i for i in inspect_result.non_validated if i not in include_validated
+    ]
+
+    return inspect_result
+
+
+def check_registry_organism(registry: Record, organism: str | None = None) -> dict:
+    """Check if a registry needs an organism and return the organism name."""
+    if hasattr(registry, "organism_id"):
+        import bionty as bt
+
+        if organism is None and bt.settings.organism is None:
+            raise ValueError(
+                f"{registry.__name__} registry requires an organism!\n"
+                "      → please pass an organism name via organism="
+            )
+        return {"organism": organism or bt.settings.organism.name}
+    return {}
+
+
+def validate_categories(
+    values: Iterable[str],
+    field: FieldAttr,
+    key: str,
+    using_key: str | None = None,
+    organism: str | None = None,
+    source: Record | None = None,
+    exclude: str | list | None = None,
+    standardize: bool = True,
+    validated_hint_print: str | None = None,
+) -> tuple[bool, list]:
+    """Validate ontology terms in a pandas series using LaminDB registries.
+
+    Args:
+        values: The values to validate.
+        field: The field attribute.
+        key: The key referencing the slot in the DataFrame.
+        using_key: A reference LaminDB instance.
+        organism: The organism name.
+        source: The source record.
+        exclude: Exclude specific values.
+        standardize: Standardize the values.
+        validated_hint_print: The hint to print for validated values.
+    """
+    from lamindb._from_values import _print_values
+    from lamindb.core._settings import settings
+
+    model_field = f"{field.field.model.__name__}.{field.field.name}"
+
+    def _log_mapping_info():
+        logger.indent = ""
+        logger.info(f"mapping {colors.italic(key)} on {colors.italic(model_field)}")
+        logger.indent = "   "
+
+    registry = field.field.model
+
+    kwargs = check_registry_organism(registry, organism)
+    kwargs.update({"source": source} if source else {})
+    kwargs_current = get_current_filter_kwargs(registry, kwargs)
+
+    # inspect the default instance
+    inspect_result = standardize_and_inspect(
+        values=values,
+        field=field,
+        registry=registry,
+        standardize=standardize,
+        exclude=exclude,
+        **kwargs_current,
+    )
+    non_validated = inspect_result.non_validated
+
+    # inspect the using instance
+    values_validated = []
+    if using_key is not None and using_key != "default" and non_validated:
+        registry_using = get_registry_instance(registry, using_key)
+        inspect_result = standardize_and_inspect(
+            values=non_validated,
+            field=field,
+            registry=registry_using,
+            standardize=standardize,
+            exclude=exclude,
+            **kwargs,
+        )
+        non_validated = inspect_result.non_validated
+        values_validated += inspect_result.validated
+
+    # inspect from public (bionty only)
+    if hasattr(registry, "public"):
+        verbosity = settings.verbosity
+        try:
+            settings.verbosity = "error"
+            public_records = registry.from_values(
+                non_validated,
+                field=field,
+                **kwargs_current,
+            )
+            values_validated += [getattr(r, field.field.name) for r in public_records]
+        finally:
+            settings.verbosity = verbosity
+
+    validated_hint_print = validated_hint_print or f".add_validated_from('{key}')"
+    n_validated = len(values_validated)
+    if n_validated > 0:
+        _log_mapping_info()
+        logger.warning(
+            f"found {colors.yellow(n_validated)} validated terms: "
+            f"{colors.yellow(values_validated)}\n      → save terms via "
+            f"{colors.yellow(validated_hint_print)}"
+        )
+
+    non_validated_hint_print = f".add_new_from('{key}')"
+    non_validated = [i for i in non_validated if i not in values_validated]
+    n_non_validated = len(non_validated)
+    if n_non_validated == 0:
+        if n_validated == 0:
+            logger.indent = ""
+            logger.success(f"{key} is validated against {colors.italic(model_field)}")
+            return True, []
+        else:
+            # validated values still need to be saved to the current instance
+            return False, []
+    else:
+        are = "are" if n_non_validated > 1 else "is"
+        print_values = _print_values(non_validated)
+        warning_message = (
+            f"{colors.red(f'{n_non_validated} terms')} {are} not validated: "
+            f"{colors.red(print_values)}\n      → fix typos, remove non-existent values, or save terms via "
+            f"{colors.red(non_validated_hint_print)}"
+        )
+        if logger.indent == "":
+            _log_mapping_info()
+        logger.warning(warning_message)
+        logger.indent = ""
+        return False, non_validated
+
+
+def validate_categories_in_df(
+    df: pd.DataFrame,
+    fields: dict[str, FieldAttr],
+    using_key: str | None = None,
+    sources: dict[str, Record] = None,
+    exclude: dict | None = None,
+    **kwargs,
+) -> tuple[bool, dict]:
+    """Validate categories in DataFrame columns using LaminDB registries."""
+    if not fields:
+        return True, {}
+
+    if sources is None:
+        sources = {}
+    validated = True
+    non_validated = {}
+    for key, field in fields.items():
+        is_val, non_val = validate_categories(
+            df[key],
+            field=field,
+            key=key,
+            using_key=using_key,
+            source=sources.get(key),
+            exclude=exclude.get(key) if exclude else None,
+            **kwargs,
+        )
+        validated &= is_val
+        if len(non_val) > 0:
+            non_validated[key] = non_val
+    return validated, non_validated
+
+
+def save_artifact(
+    data: pd.DataFrame | ad.AnnData | MuData,
+    fields: dict[str, FieldAttr] | dict[str, dict[str, FieldAttr]],
+    columns_field: FieldAttr | dict[str, FieldAttr],
+    description: str | None = None,
+    organism: str | None = None,
+    adata: ad.AnnData | None = None,
+    **kwargs,
+) -> Artifact:
+    """Save all metadata with an Artifact.
+
+    Args:
+        data: The DataFrame or AnnData object to save.
+        description: A description of the artifact.
+        fields: A dictionary mapping obs_column to registry_field.
+        columns_field: The registry field to validate variables index against.
+        organism: The organism name.
+        adata: The AnnData object to save, must be provided if data is a path.
+        kwargs: Additional keyword arguments to pass to the registry model.
+
+    Returns:
+        The saved Artifact.
+    """
+    from ._artifact import data_is_anndata
+
+    artifact = None
+    if data_is_anndata(data):
+        assert adata is not None  # noqa: S101
+        artifact = Artifact.from_anndata(data, description=description, **kwargs)
+        artifact.n_observations = adata.shape[0]
+        data = adata
+
+    elif isinstance(data, pd.DataFrame):
+        artifact = Artifact.from_df(data, description=description, **kwargs)
+    else:
+        try:
+            from mudata import MuData
+
+            if isinstance(data, MuData):
+                artifact = Artifact.from_mudata(data, description=description, **kwargs)
+                artifact.n_observations = data.n_obs
+        except ImportError:
+            pass
+    if artifact is None:
+        raise ValueError("data must be a DataFrame, AnnData or MuData object.")
+    artifact.save()
+
+    feature_kwargs = check_registry_organism(
+        (
+            list(columns_field.values())[0].field.model
+            if isinstance(columns_field, dict)
+            else columns_field.field.model
+        ),
+        organism,
+    )
+
+    if artifact._accessor == "DataFrame":
+        artifact.features._add_set_from_df(field=columns_field, **feature_kwargs)
+    elif artifact._accessor == "AnnData":
+        artifact.features._add_set_from_anndata(
+            var_field=columns_field, **feature_kwargs
+        )
+    elif artifact._accessor == "MuData":
+        artifact.features._add_set_from_mudata(
+            var_fields=columns_field, **feature_kwargs
+        )
+    else:
+        raise NotImplementedError
+
+    def _add_labels(data, artifact: Artifact, fields: dict[str, FieldAttr]):
+        features = Feature.lookup().dict()
+        for key, field in fields.items():
+            feature = features.get(key)
+            registry = field.field.model
+            filter_kwargs = check_registry_organism(registry, organism)
+            filter_kwargs_current = get_current_filter_kwargs(registry, filter_kwargs)
+            df = data if isinstance(data, pd.DataFrame) else data.obs
+            labels = registry.from_values(
+                df[key],
+                field=field,
+                **filter_kwargs_current,
+            )
+            artifact.labels.add(labels, feature)
+
+    if artifact._accessor == "MuData":
+        for modality, modality_fields in fields.items():
+            if modality == "obs":
+                _add_labels(data, artifact, modality_fields)
+            else:
+                _add_labels(data[modality], artifact, modality_fields)
+    else:
+        _add_labels(data, artifact, fields)
+
+    slug = ln_setup.settings.instance.slug
+    if ln_setup.settings.instance.is_remote:  # pragma: no cover
+        logger.important(f"go to https://lamin.ai/{slug}/artifact/{artifact.uid}")
+    return artifact
+
+
+def update_registry(
+    values: list[str],
+    field: FieldAttr,
+    key: str,
+    save_function: str = "add_new_from",
+    using_key: str | None = None,
+    validated_only: bool = True,
+    df: pd.DataFrame | None = None,
+    organism: str | None = None,
+    dtype: str | None = None,
+    source: Record | None = None,
+    standardize: bool = True,
+    warning: bool = True,
+    exclude: str | list | None = None,
+    **kwargs,
+) -> None:
+    """Save features or labels records in the default instance from the using_key instance.
+
+    Args:
+        values: A list of values to be saved as labels.
+        field: The FieldAttr object representing the field for which labels are being saved.
+        key: The name of the feature to save.
+        save_function: The name of the function to save the labels.
+        using_key: The name of the instance from which to transfer labels (if applicable).
+        validated_only: If True, only save validated labels.
+        df: A DataFrame to save labels from.
+        organism: The organism name.
+        dtype: The type of the feature.
+        source: The source record.
+        kwargs: Additional keyword arguments to pass to the registry model to create new records.
+    """
+    from lamindb._save import save as ln_save
+    from lamindb.core._settings import settings
+
+    registry = field.field.model
+    filter_kwargs = check_registry_organism(registry, organism)
+    filter_kwargs.update({"source": source} if source else {})
+
+    verbosity = settings.verbosity
+    try:
+        settings.verbosity = "error"
+
+        # save from public
+        filter_kwargs_current = get_current_filter_kwargs(registry, filter_kwargs)
+        existing_and_public_records = (
+            registry.from_values(
+                list(values),
+                field=field,
+                **filter_kwargs_current,
+            )
+            if values
+            else []
+        )
+
+        labels_saved: dict = {"from public": [], "without reference": []}
+
+        public_records = [r for r in existing_and_public_records if r._state.adding]
+        # here we check to only save the public records if they are from the specified source
+        # we check the uid because r.source and soruce can be from different instances
+        if source:
+            public_records = [r for r in public_records if r.source.uid == source.uid]
+        ln_save(public_records)
+        labels_saved["from public"] = [
+            getattr(r, field.field.name) for r in public_records
+        ]
+        non_public_labels = [i for i in values if i not in labels_saved["from public"]]
+
+        # inspect the default instance
+        inspect_result_current = standardize_and_inspect(
+            values=non_public_labels,
+            field=field,
+            registry=registry,
+            standardize=standardize,
+            exclude=exclude,
+            **filter_kwargs_current,
+        )
+        if not inspect_result_current.non_validated:
+            all_labels = registry.from_values(
+                inspect_result_current.validated,
+                field=field,
+                **filter_kwargs_current,
+            )
+            settings.verbosity = verbosity
+            return all_labels
+
+        # inspect the using_key instance
+        (
+            labels_saved[f"from {using_key}"],
+            non_validated_labels,
+        ) = update_registry_from_using_instance(
+            inspect_result_current.non_validated,
+            field=field,
+            using_key=using_key,
+            exclude=exclude,
+            **filter_kwargs,
+        )
+
+        labels_saved["without reference"] = [
+            i
+            for i in non_validated_labels
+            if i not in labels_saved[f"from {using_key}"]
+        ]
+
+        # save non-validated records
+        if not validated_only:
+            non_validated_records = []
+            if df is not None and registry == Feature:
+                non_validated_records = Feature.from_df(df)
+            else:
+                if "organism" in filter_kwargs:
+                    # make sure organism record is saved to the current instance
+                    filter_kwargs["organism"] = _save_organism(name=organism)
+                init_kwargs = {}
+                for value in labels_saved["without reference"]:
+                    init_kwargs[field.field.name] = value
+                    if registry == Feature:
+                        init_kwargs["dtype"] = "cat" if dtype is None else dtype
+                    non_validated_records.append(
+                        registry(
+                            **init_kwargs,
+                            **{k: v for k, v in filter_kwargs.items() if k != "source"},
+                            **{k: v for k, v in kwargs.items() if k != "sources"},
+                        )
+                    )
+            ln_save(non_validated_records)
+
+        # save parent labels for ulabels
+        if registry == ULabel and field.field.name == "name":
+            save_ulabels_with_parent(values, field=field, key=key)
+
+        # # get all records that are now validated in the current instance
+        # all_labels = registry.from_values(
+        #     inspect_result_current.validated + inspect_result_current.non_validated,
+        #     field=field,
+        #     **get_current_filter_kwargs(registry, filter_kwargs),
+        # )
+    finally:
+        settings.verbosity = verbosity
+
+    log_saved_labels(
+        labels_saved,
+        key=key,
+        save_function=save_function,
+        model_field=f"{registry.__name__}.{field.field.name}",
+        validated_only=validated_only,
+        warning=warning,
+    )
+
+    # return all_labels
+
+
+def log_saved_labels(
+    labels_saved: dict,
+    key: str,
+    save_function: str,
+    model_field: str,
+    validated_only: bool = True,
+    warning: bool = True,
+) -> None:
+    """Log the saved labels."""
+    from ._from_values import _print_values
+
+    model_field = colors.italic(model_field)
+    for k, labels in labels_saved.items():
+        if not labels:
+            continue
+
+        if k == "without reference" and validated_only:
+            msg = colors.yellow(
+                f"{len(labels)} non-validated values are not saved in {model_field}: {labels}!"
+            )
+            lookup_print = (
+                f"lookup().{key}" if key.isidentifier() else f".lookup()['{key}']"
+            )
+
+            hint = f".add_new_from('{key}')"
+            msg += f"\n      → to lookup values, use {lookup_print}"
+            msg += (
+                f"\n      → to save, run {colors.yellow(hint)}"
+                if save_function == "add_new_from"
+                else f"\n      → to save, run {colors.yellow(save_function)}"
+            )
+            if warning:
+                logger.warning(msg)
+            else:
+                logger.info(msg)
+        else:
+            k = "" if k == "without reference" else f"{colors.green(k)} "
+            # the term "transferred" stresses that this is always in the context of transferring
+            # labels from a public ontology or a different instance to the present instance
+            s = "s" if len(labels) > 1 else ""
+            logger.success(
+                f"added {len(labels)} record{s} {k}with {model_field} for {colors.italic(key)}: {_print_values(labels)}"
+            )
+
+
+def save_ulabels_with_parent(values: list[str], field: FieldAttr, key: str) -> None:
+    """Save a parent label for the given labels."""
+    registry = field.field.model
+    assert registry == ULabel  # noqa: S101
+    all_records = registry.from_values(list(values), field=field)
+    is_feature = registry.filter(name=f"is_{key}").one_or_none()
+    if is_feature is None:
+        is_feature = registry(name=f"is_{key}")
+        is_feature.save()
+    is_feature.children.add(*all_records)
+
+
+def update_registry_from_using_instance(
+    values: list[str],
+    field: FieldAttr,
+    using_key: str | None = None,
+    standardize: bool = False,
+    exclude: str | list | None = None,
+    **kwargs,
+) -> tuple[list[str], list[str]]:
+    """Save features or labels records from the using_key instance.
+
+    Args:
+        values: A list of values to be saved as labels.
+        field: The FieldAttr object representing the field for which labels are being saved.
+        using_key: The name of the instance from which to transfer labels (if applicable).
+        standardize: Whether to also standardize the values.
+        kwargs: Additional keyword arguments to pass to the registry model.
+
+    Returns:
+        A tuple containing the list of saved labels and the list of non-saved labels.
+    """
+    labels_saved = []
+    not_saved = values
+
+    if using_key is not None and using_key != "default":
+        registry_using = get_registry_instance(field.field.model, using_key)
+
+        inspect_result_using = standardize_and_inspect(
+            values=values,
+            field=field,
+            registry=registry_using,
+            standardize=standardize,
+            exclude=exclude,
+            **kwargs,
+        )
+        labels_using = registry_using.filter(
+            **{f"{field.field.name}__in": inspect_result_using.validated}
+        ).all()
+        for label_using in labels_using:
+            label_using.save()
+            labels_saved.append(getattr(label_using, field.field.name))
+        not_saved = inspect_result_using.non_validated
+
+    return labels_saved, not_saved
+
+
+def _save_organism(name: str):  # pragma: no cover
+    """Save an organism record."""
+    import bionty as bt
+
+    organism = bt.Organism.filter(name=name).one_or_none()
+    if organism is None:
+        organism = bt.Organism.from_source(name=name)
+        if organism is None:
+            raise ValueError(
+                f"Organism '{name}' not found\n"
+                f"      → please save it: bt.Organism(name='{name}').save()"
+            )
+        organism.save()
+    return organism
+
+
+Curate = Curator  # backward compat