@sjcrh/proteinpaint-client 2.207.1 → 2.209.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (940) hide show
  1. package/dist/2dmaf-VTMPVZGT.js +1367 -0
  2. package/dist/AggMatrixInput-CH3RQ2QC.js +406 -0
  3. package/dist/AggMatrixInput-CH3RQ2QC.js.map +7 -0
  4. package/dist/AggregateMatrix-DPCHUOMF.js +41 -0
  5. package/dist/AppHeader-RA7T467G.js +830 -0
  6. package/dist/BoxPlot-7Q7SMT26.js +1211 -0
  7. package/dist/CorrelationVolcano-YV4UHOAX.js +617 -0
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  9. package/dist/Cuminc-ZN53C3MD.js +1219 -0
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  15. package/dist/Disco-PTZQF7IM.js +3389 -0
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  23. package/dist/GeneExpInput-DYBK54HC.js +42 -0
  24. package/dist/Geomap-QRD2WZVL.js +84 -0
  25. package/dist/HicApp-VKET4QHD.js +2245 -0
  26. package/dist/IDCViewer-RLLTXGD7.js +10812 -0
  27. package/dist/NumBinaryEditor-GYHOYPQL.js +279 -0
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  43. package/dist/ProteomeInput-4N2G6IFX.js +388 -0
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  188. package/dist/dnaMethylation-CX22TSRO.js +33 -0
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  846. /package/dist/{matrix.groups-URBU775S.js.map → matrix.groups-F62TSKIG.js.map} +0 -0
  847. /package/dist/{matrix.interactivity-W5AFOAQN.js.map → matrix.interactivity-2FBXB52E.js.map} +0 -0
  848. /package/dist/{matrix.layout-LU3NIJAL.js.map → matrix.layout-6TPVKLSX.js.map} +0 -0
  849. /package/dist/{matrix.legend-LTP6ETZO.js.map → matrix.legend-L4ULBMGX.js.map} +0 -0
  850. /package/dist/{matrix.renderers-762XI65L.js.map → matrix.renderers-DK6YRLO2.js.map} +0 -0
  851. /package/dist/{matrix.serieses-FHDBRPZA.js.map → matrix.serieses-DCRJLJ3H.js.map} +0 -0
  852. /package/dist/{matrix.sort-Q6A6UWMY.js.map → matrix.sort-XSGPH44J.js.map} +0 -0
  853. /package/dist/{matrix.sort.unit.spec-CTCOPKVS.js.map → matrix.sort.unit.spec-JF75F4I4.js.map} +0 -0
  854. /package/dist/{matrix.sorterUi-4M5AU5EL.js.map → matrix.sorterUi-WL5I6S3K.js.map} +0 -0
  855. /package/dist/{matrix.sorterUi.unit.spec-Y7GC3PM5.js.map → matrix.sorterUi.unit.spec-66JMV5BK.js.map} +0 -0
  856. /package/dist/{matrix.unit.spec-DROPHFTM.js.map → matrix.unit.spec-36AR4I43.js.map} +0 -0
  857. /package/dist/{mavb-BWA73N3U.js.map → mavb-ZH4RO77H.js.map} +0 -0
  858. /package/dist/{mds.fimo-3UJWIH2J.js.map → mds.fimo-MVP2G5PS.js.map} +0 -0
  859. /package/dist/{mds.samplescatterplot-EUS7DCSQ.js.map → mds.samplescatterplot-GYJ3OI4N.js.map} +0 -0
  860. /package/dist/{mds.survivalplot-77UEBQIC.js.map → mds.survivalplot-Q6MYQGTB.js.map} +0 -0
  861. /package/dist/{multivalue-KZ2DMVIR.js.map → multivalue-BGFMPH4X.js.map} +0 -0
  862. /package/dist/{numericDictTermCluster-C2MYJYPZ.js.map → numericDictTermCluster-FNNVLIWB.js.map} +0 -0
  863. /package/dist/{oncomatrix-6LGB3M7R.js.map → oncomatrix-LIIALWWN.js.map} +0 -0
  864. /package/dist/{oncomatrix.spec-UWMSLOHW.js.map → oncomatrix.spec-NEMLM2ZN.js.map} +0 -0
  865. /package/dist/{plot.2dvaf-LZAVWH65.js.map → plot.2dvaf-HJO3SKNK.js.map} +0 -0
  866. /package/dist/{plot.app-OEWE3AYV.js.map → plot.app-WSLFOFSR.js.map} +0 -0
  867. /package/dist/{plot.barplot-VIBHGTUT.js.map → plot.barplot-SPI5JA37.js.map} +0 -0
  868. /package/dist/{plot.boxplot-NQI3PSKR.js.map → plot.boxplot-4W3XEY5I.js.map} +0 -0
  869. /package/dist/{plot.brainImaging-3MTTCZHI.js.map → plot.brainImaging-KEOUTYIB.js.map} +0 -0
  870. /package/dist/{plot.disco-HODBY7SO.js.map → plot.disco-7IDMKNAQ.js.map} +0 -0
  871. /package/dist/{plot.ssgq-4URQE673.js.map → plot.ssgq-IOKUGDC4.js.map} +0 -0
  872. /package/dist/{plot.vaf2cov-QIJNEKCK.js.map → plot.vaf2cov-SFSZ6M43.js.map} +0 -0
  873. /package/dist/{polar2-GVFQNSLK.js.map → polar2-PLPE5TX5.js.map} +0 -0
  874. /package/dist/{profileForms-Z22CJXI4.js.map → profileForms-ZDHG67GM.js.map} +0 -0
  875. /package/dist/{profilePlot-IVQZBSID.js.map → profilePlot-UUZA2YG6.js.map} +0 -0
  876. /package/dist/{proteinView-AUK634AU.js.map → proteinView-GHS3XARL.js.map} +0 -0
  877. /package/dist/{proteomeCohortCompare-7G2F35H5.js.map → proteomeCohortCompare-TQ3BGIPS.js.map} +0 -0
  878. /package/dist/{pseudobulk-QTCUSH5I.js.map → pseudobulk-ODXYIUD5.js.map} +0 -0
  879. /package/dist/{qualitative-7ST7SSBT.js.map → qualitative-WOSYAIGQ.js.map} +0 -0
  880. /package/dist/{radar2-CEE6SNBS.js.map → radar2-2KXBS3Y3.js.map} +0 -0
  881. /package/dist/{radarFacility2-OSKDYIK7.js.map → radarFacility2-JCOKJQQF.js.map} +0 -0
  882. /package/dist/{rememberedGvQ.unit.spec-RYFUJ2NW.js.map → rememberedGvQ.unit.spec-DYRO2LO5.js.map} +0 -0
  883. /package/dist/{render-MAD3WMVD.js.map → render-IJ6GE3NE.js.map} +0 -0
  884. /package/dist/{report-6JXJVSEB.js.map → report-WLLFUA7L.js.map} +0 -0
  885. /package/dist/{sampleView-SG3QYZKQ.js.map → sampleView-LPKSYUNF.js.map} +0 -0
  886. /package/dist/{samplelst-R765UFP6.js.map → samplelst-MNI2MGMT.js.map} +0 -0
  887. /package/dist/{samplematrix-EBJYE5SM.js.map → samplematrix-KEKJP2B4.js.map} +0 -0
  888. /package/dist/{sc-7ZXPFDHD.js.map → sc-ZYKFRJU4.js.map} +0 -0
  889. /package/dist/{scatter-3GUL4KF3.js.map → scatter-BAEZOFWA.js.map} +0 -0
  890. /package/dist/{selectGenomeWithTklst-K4YXGJYG.js.map → selectGenomeWithTklst-HBHRXEDY.js.map} +0 -0
  891. /package/dist/{singleCellCellType-TU5VTPLP.js.map → singleCellCellType-PMFDV24B.js.map} +0 -0
  892. /package/dist/{singleCellCellType.unit.spec-IRITQIGT.js.map → singleCellCellType.unit.spec-ZLYDUDIY.js.map} +0 -0
  893. /package/dist/{singleCellGeneExpression-3IL52QDK.js.map → singleCellGeneExpression-SUYO3HR3.js.map} +0 -0
  894. /package/dist/{singleCellGeneExpression.unit.spec-WXC4C37T.js.map → singleCellGeneExpression.unit.spec-3N3HRXFN.js.map} +0 -0
  895. /package/dist/{singleCellPlot-XG3HZS7I.js.map → singleCellNumericValue-BV7C6Y34.js.map} +0 -0
  896. /package/dist/{snp-RMZRB426.js.map → singleCellPlot-BG7UJOHA.js.map} +0 -0
  897. /package/dist/{singlecell-BRF2HAV2.js.map → singlecell-BANNFGBS.js.map} +0 -0
  898. /package/dist/{singlecell-KVCJF2HI.js.map → singlecell-ZUTL5ZWE.js.map} +0 -0
  899. /package/dist/{ssGSEA-7RKWYZKX.js.map → snp-BHG4NVK4.js.map} +0 -0
  900. /package/dist/{snp.unit.spec-JF6KR2NT.js.map → snp.unit.spec-Q3AZHQRC.js.map} +0 -0
  901. /package/dist/{snplocus-AHUFHQ3Q.js.map → snplocus-HTJL63M3.js.map} +0 -0
  902. /package/dist/{spliceevent.a53ss.diagram-OSZZ2CF2.js.map → spliceevent.a53ss.diagram-UKRIP7EP.js.map} +0 -0
  903. /package/dist/{spliceevent.exonskip.diagram-AMA2D2OL.js.map → spliceevent.exonskip.diagram-CU777CXQ.js.map} +0 -0
  904. /package/dist/{spliceevent.noeventdiagram-RKTUXH5D.js.map → spliceevent.noeventdiagram-LGLXCF25.js.map} +0 -0
  905. /package/dist/{summarizeMutationDiagnosis-GCL4SRON.js.map → ssGSEA-BIEEKAKX.js.map} +0 -0
  906. /package/dist/{ssGSEA.unit.spec-XLCZHH7S.js.map → ssGSEA.unit.spec-YD4UDIRH.js.map} +0 -0
  907. /package/dist/{stattable-NDYUCLVZ.js.map → stattable-LFR3RSD6.js.map} +0 -0
  908. /package/dist/{studyCatalog-TAXRF5NS.js.map → studyCatalog-RINIZ277.js.map} +0 -0
  909. /package/dist/{summarizeCnvGeneexp-3QLHU6N7.js.map → summarizeCnvGeneexp-ZQFNPR65.js.map} +0 -0
  910. /package/dist/{summarizeGeneexpSurvival-ARI4MPFX.js.map → summarizeGeneexpSurvival-GIS7XMMH.js.map} +0 -0
  911. /package/dist/{summarizeMutationCnv-W7V7CKPI.js.map → summarizeMutationCnv-FWF7YIGR.js.map} +0 -0
  912. /package/dist/{summary-OUYDWLBF.js.map → summarizeMutationDiagnosis-V5L2OKTK.js.map} +0 -0
  913. /package/dist/{summarizeMutationSurvival-6TTMSRRX.js.map → summarizeMutationSurvival-LAUUF6XN.js.map} +0 -0
  914. /package/dist/{termCollection-7P3WU6X6.js.map → summary-OMU3ACNE.js.map} +0 -0
  915. /package/dist/{summary.integration.spec-4GTCG6HY.js.map → summary.integration.spec-6JZAT73L.js.map} +0 -0
  916. /package/dist/{summaryInput-UK3TLC7M.js.map → summaryInput-QIKL3HDD.js.map} +0 -0
  917. /package/dist/{sunburst-2UFHMNH3.js.map → sunburst-32IW2R57.js.map} +0 -0
  918. /package/dist/{survival-SPWYSDVB.js.map → survival-BMOPVAN2.js.map} +0 -0
  919. /package/dist/{survival-TL6UZ6FQ.js.map → survival-H5AWMQ36.js.map} +0 -0
  920. /package/dist/{svgraph-Z543MLIN.js.map → svgraph-B75FS3BB.js.map} +0 -0
  921. /package/dist/{svmr-SZCAOAIF.js.map → svmr-IUEUOHVO.js.map} +0 -0
  922. /package/dist/{table-IAQ6J4DO.js.map → table-YAAH7WR6.js.map} +0 -0
  923. /package/dist/{termCollection-3NGHR7QN.js.map → termCollection-7F5ZG2DB.js.map} +0 -0
  924. /package/dist/{termCollectionFractionSelection-YKIE6BME.js.map → termCollection-KNFUELYY.js.map} +0 -0
  925. /package/dist/{termCollection.unit.spec-EPYC7LOA.js.map → termCollection.unit.spec-S6M6QC4C.js.map} +0 -0
  926. /package/dist/{tk-X454XH5N.js.map → termCollectionFractionSelection-X22VMJWY.js.map} +0 -0
  927. /package/dist/{termCollectionFractionSelection.unit.spec-AG2CZPGZ.js.map → termCollectionFractionSelection.unit.spec-ELU6SD7P.js.map} +0 -0
  928. /package/dist/{tvs.dt-U77PCG6X.js.map → tk-TT666UVE.js.map} +0 -0
  929. /package/dist/{tk-TOXMU4GT.js.map → tk-UOPNJ323.js.map} +0 -0
  930. /package/dist/{tp.ui-FDQ76KPL.js.map → tp.ui-HGAHRKO5.js.map} +0 -0
  931. /package/dist/{vocabulary-64GO4YDB.js.map → tvs.dt-H7YYR4EB.js.map} +0 -0
  932. /package/dist/{tvs.dtcnv.categorical-XYZU4XLO.js.map → tvs.dtcnv.categorical-IPJTKGMF.js.map} +0 -0
  933. /package/dist/{tvs.dtcnv.continuous-4GJILFGP.js.map → tvs.dtcnv.continuous-XY5XZ4GH.js.map} +0 -0
  934. /package/dist/{tvs.dtfusion-7YROAHVI.js.map → tvs.dtfusion-VFCBMXRM.js.map} +0 -0
  935. /package/dist/{tvs.dtitd-MIYU4ZHH.js.map → tvs.dtitd-RZVW6FTR.js.map} +0 -0
  936. /package/dist/{tvs.dtsnvindel-XLDY7KWB.js.map → tvs.dtsnvindel-IDPJWSGC.js.map} +0 -0
  937. /package/dist/{tvs.dtsv-YMLJ37YR.js.map → tvs.dtsv-QERP756F.js.map} +0 -0
  938. /package/dist/{tvs.samplelst-KIVEXJKD.js.map → tvs.samplelst-6KNDHBIU.js.map} +0 -0
  939. /package/dist/{tvs.termCollection-4CQV3EB3.js.map → tvs.termCollection-GWPJK3NE.js.map} +0 -0
  940. /package/dist/{wsi.direct-5MQVRJZX.js.map → wsi.direct-2RBCBXDA.js.map} +0 -0
@@ -0,0 +1,70 @@
1
+ import {
2
+ junctionCustomTermSource
3
+ } from "./chunk-JTANDSTD.js";
4
+ import {
5
+ mayRenderFractionSelection
6
+ } from "./chunk-C3HEDQPT.js";
7
+
8
+ // termdb/handlers/junction.ts
9
+ var SearchHandler = class {
10
+ async init(opts) {
11
+ if (!opts?.holder) throw new Error("opts.holder is required");
12
+ if (typeof opts.callback != "function") throw new Error("opts.callback is required");
13
+ const entries = getJunctionCustomTerms(opts.app.vocabApi.state?.customTerms);
14
+ render(opts, entries);
15
+ }
16
+ };
17
+ function getJunctionCustomTerms(customTerms) {
18
+ if (!Array.isArray(customTerms)) return [];
19
+ return customTerms.filter((term) => term?.source === junctionCustomTermSource && term.tw?.term);
20
+ }
21
+ function render(opts, entries) {
22
+ const holder = opts.holder;
23
+ holder.selectAll("*").remove();
24
+ const div = holder.append("div").style("padding", "10px 0px");
25
+ if (!entries.length) {
26
+ div.append("div").text("Junctions selected from genome browser will be shown here.");
27
+ return;
28
+ }
29
+ const listDiv = div.append("div");
30
+ const fractionDiv = div.append("div");
31
+ for (const entry of entries) {
32
+ if (entry.eventlabel) renderJunctionEvent(listDiv, fractionDiv, entry, opts);
33
+ else renderJunction(listDiv, entry, opts);
34
+ }
35
+ listDiv.append("div").style("font-size", ".7em").style("margin-top", "10px").style("opacity", 0.7).text("Select additional junctions from genome browser.");
36
+ }
37
+ function renderJunction(holder, entry, opts) {
38
+ const choice = holder.append("div");
39
+ choice.append("div").attr("class", "ts_pill sja_filter_tag_btn sja_tree_click_term").style("display", "inline-block").style("border-radius", "6px").style("margin", "1px 0").text(entry.tw.term.name).on("click", () => opts.callback(entry.tw.term));
40
+ addDeleteButton(choice, entry, opts);
41
+ }
42
+ function renderJunctionEvent(holder, fractionDiv, entry, opts) {
43
+ const eventHolder = holder.append("div");
44
+ const pillRow = eventHolder.append("div");
45
+ pillRow.append("div").attr("class", "ts_pill sja_filter_tag_btn sja_tree_click_term").style("display", "inline-block").style("border-radius", "6px").style("margin", "1px 0").text(entry.eventlabel).on("click", () => selectJunctionEvent(holder, fractionDiv, entry, opts));
46
+ addDeleteButton(pillRow, entry, opts);
47
+ eventHolder.append("div").style("margin-left", "10px").style("font-size", ".7em").selectAll("div").data(entry.tw.term.termlst, (term) => term.id).enter().append("div").text((term) => term.name);
48
+ }
49
+ function selectJunctionEvent(listDiv, fractionDiv, entry, opts) {
50
+ const isStaged = mayRenderFractionSelection({
51
+ term: entry.tw.term,
52
+ selectionMode: opts.termCollectionSelectionMode,
53
+ listDiv,
54
+ fractionDiv,
55
+ callback: (tw) => opts.callback(tw)
56
+ });
57
+ if (!isStaged) opts.callback(entry.tw.term);
58
+ }
59
+ function addDeleteButton(holder, entry, opts) {
60
+ holder.append("button").attr("data-testid", "sjpp-junction-delete").style("margin-left", "4px").attr("aria-label", `Delete ${entry.name}`).text("\xD7").on("click", async () => {
61
+ await opts.app.vocabApi.deleteCustomTermById(entry.id);
62
+ render(opts, getJunctionCustomTerms(opts.app.vocabApi.state?.customTerms));
63
+ });
64
+ }
65
+
66
+ export {
67
+ SearchHandler,
68
+ getJunctionCustomTerms
69
+ };
70
+ //# sourceMappingURL=chunk-6LDKSKYQ.js.map
@@ -0,0 +1,272 @@
1
+ import {
2
+ fillbar,
3
+ make_table_2col
4
+ } from "./chunk-C3HEDQPT.js";
5
+
6
+ // src/block.mds.expressionstat.js
7
+ var color_noinfo = "#858585";
8
+ function init_config(cfg) {
9
+ if (!cfg.datatype) cfg.datatype = "FPKM";
10
+ if (!cfg.itemcolor) cfg.itemcolor = "green";
11
+ if (!cfg.ase) cfg.ase = {};
12
+ if (cfg.ase.qvalue == void 0) cfg.ase.qvalue = 0.05;
13
+ if (cfg.ase.meandelta_monoallelic == void 0) cfg.ase.meandelta_monoallelic = 0.3;
14
+ if (cfg.ase.asemarkernumber_biallelic == void 0) cfg.ase.asemarkernumber_biallelic = 0;
15
+ if (!cfg.ase.color_noinfo) cfg.ase.color_noinfo = color_noinfo;
16
+ if (!cfg.ase.color_uncertain) cfg.ase.color_uncertain = "#A8E0B5";
17
+ if (!cfg.ase.color_biallelic) cfg.ase.color_biallelic = "#40859C";
18
+ if (!cfg.ase.color_monoallelic) cfg.ase.color_monoallelic = "#d95f02";
19
+ if (!cfg.outlier) cfg.outlier = {};
20
+ if (cfg.outlier.pvalue_cutoff == void 0) cfg.outlier.pvalue_cutoff = 0.05;
21
+ if (cfg.outlier.rank_asehigh_cutoff == void 0) cfg.outlier.rank_asehigh_cutoff = 0.1;
22
+ if (!cfg.outlier.color_outlier) cfg.outlier.color_outlier = "#FF8875";
23
+ if (!cfg.outlier.color_outlier_asehigh) cfg.outlier.color_outlier_asehigh = "blue";
24
+ }
25
+ function measure(v, cfg) {
26
+ if (!cfg) return;
27
+ v.estat = {};
28
+ if (v.ase && cfg.ase) {
29
+ const qvalue = v.ase.qvalue || v.ase.geometricmean;
30
+ if (qvalue == void 0) {
31
+ v.estat.ase_noinfo = true;
32
+ } else if (qvalue <= cfg.ase.qvalue) {
33
+ if (v.ase.mean_delta >= cfg.ase.meandelta_monoallelic) {
34
+ v.estat.ase_monoallelic = true;
35
+ } else {
36
+ v.estat.ase_uncertain = true;
37
+ }
38
+ } else {
39
+ if (v.ase.ase_markers == cfg.ase.asemarkernumber_biallelic) {
40
+ v.estat.ase_biallelic = true;
41
+ } else {
42
+ v.estat.ase_uncertain = true;
43
+ }
44
+ }
45
+ } else {
46
+ v.estat.ase_noinfo = true;
47
+ }
48
+ if (v.outlier && cfg.outlier) {
49
+ if (v.outlier.test_whitelist) {
50
+ if (v.outlier.test_whitelist.pvalue <= cfg.outlier.pvalue_cutoff) {
51
+ v.estat.outlier = true;
52
+ } else {
53
+ if (v.estat.ase_monoallelic) {
54
+ if (Number.isInteger(v.outlier.test_whitelist.rank) && Number.isInteger(v.outlier.test_whitelist.size) && v.outlier.test_whitelist.rank / v.outlier.test_whitelist.size <= cfg.outlier.rank_asehigh_cutoff) {
55
+ v.estat.outlier_asehigh = true;
56
+ v.outlier.test_whitelist.asehigh = true;
57
+ }
58
+ }
59
+ }
60
+ } else if (v.outlier.test_biallelic) {
61
+ if (v.outlier.test_biallelic.pvalue <= cfg.outlier.pvalue_cutoff) {
62
+ v.estat.outlier = true;
63
+ } else {
64
+ if (v.estat.ase_monoallelic) {
65
+ if (Number.isInteger(v.outlier.test_biallelic.rank) && Number.isInteger(v.outlier.test_biallelic.size) && v.outlier.test_biallelic.rank / v.outlier.test_biallelic.size <= cfg.outlier.rank_asehigh_cutoff) {
66
+ v.estat.outlier_asehigh = true;
67
+ v.outlier.test_biallelic.asehigh = true;
68
+ }
69
+ }
70
+ }
71
+ } else if (v.outlier.test_entirecohort) {
72
+ if (v.outlier.test_entirecohort.pvalue <= cfg.outlier.pvalue_cutoff) {
73
+ v.estat.outlier = true;
74
+ } else {
75
+ if (v.estat.ase_monoallelic) {
76
+ if (Number.isInteger(v.outlier.test_entirecohort.rank) && Number.isInteger(v.outlier.test_entirecohort.size) && v.outlier.test_entirecohort.rank / v.outlier.test_entirecohort.size <= cfg.outlier.rank_asehigh_cutoff) {
77
+ v.estat.outlier_asehigh = true;
78
+ v.outlier.test_entirecohort.asehigh = true;
79
+ }
80
+ }
81
+ }
82
+ }
83
+ }
84
+ }
85
+ function showsingleitem_table(v, cfg, table) {
86
+ if (!v.estat) return;
87
+ if (cfg.no_ase) return;
88
+ if (v.ase) {
89
+ const tr = table.append("tr");
90
+ tr.append("td").attr("colspan", 2).style("background", ase_color(v, cfg)).style("color", "white").html(
91
+ (v.estat.ase_monoallelic ? "Mono-allelic" : v.estat.ase_biallelic ? "Bi-allelic" : "ASE uncertain") + "<br>(allele-specific expression)"
92
+ );
93
+ const lst = [
94
+ {
95
+ k: "#SNPs heterozygous in DNA",
96
+ v: v.ase.markers
97
+ },
98
+ {
99
+ k: "#SNPs showing ASE in RNA",
100
+ v: v.ase.ase_markers
101
+ },
102
+ {
103
+ k: "Mean delta of ASE SNPs",
104
+ v: v.ase.mean_delta
105
+ }
106
+ ];
107
+ if (v.ase.qvalue) {
108
+ lst.push({
109
+ k: "Q-value",
110
+ v: v.ase.qvalue
111
+ });
112
+ } else if (v.ase.geometricmean) {
113
+ lst.push({
114
+ k: "Geometric mean of binomial P-values of ASE SNPs",
115
+ v: v.ase.geometricmean
116
+ });
117
+ }
118
+ const td = tr.append("td");
119
+ make_table_2col(td, lst);
120
+ } else {
121
+ const tr = table.append("tr");
122
+ tr.append("td").attr("colspan", 3).style("background", cfg.ase.color_noinfo).style("color", "white").text("No info on allele-specific expression");
123
+ }
124
+ if (v.snps && v.snps.length > 0) {
125
+ const hetsnp = v.snps.filter((i) => i.dnacount && i.dnacount.ishet);
126
+ if (hetsnp.length > 0) {
127
+ const lst = [];
128
+ for (const m of hetsnp) {
129
+ lst.push(
130
+ "<tr><td>" + m.chr + ":" + (m.pos + 1) + " " + m.ref + ">" + m.alt + "</td><td>" + fillbar(null, { f: m.dnacount.f }) + " " + m.dnacount.ref + "/" + m.dnacount.alt + "</td><td>" + (m.rnacount.nocoverage ? '<span style="font-size:.8em;opacity:.5">No coverage</span>' : fillbar(null, { f: m.rnacount.f }) + " " + m.rnacount.ref + "/" + m.rnacount.alt) + "</td><td>" + (m.rnacount.pvalue || "-") + "</td></tr>"
131
+ );
132
+ }
133
+ table.append("tr").append("td").attr("colspan", 3).html(
134
+ '<table style="margin-top:10px;border:solid 1px #ededed;border-spacing:5px;"><tr style="opacity:.5"><td>SNP</td><td>DNA</td><td>RNA</td><td>Binomial test P-value</td></tr>' + lst.join("") + "</table>"
135
+ );
136
+ }
137
+ }
138
+ if (v.outlier) {
139
+ if (v.outlier.test_whitelist) {
140
+ const tr = table.append("tr");
141
+ tr.append("td").attr("colspan", 2).text("Outlier (white list)");
142
+ const lst = [];
143
+ for (const k in v.outlier.test_whitelist) {
144
+ lst.push({ k, v: v.outlier.test_whitelist[k] });
145
+ }
146
+ const td = tr.append("td");
147
+ make_table_2col(td, lst);
148
+ if (v.outlier.test_whitelist.asehigh) {
149
+ td.append("div").style("background", cfg.outlier.color_outlier_asehigh).style("padding", "2px 10px").style("color", "white").text("ASE high");
150
+ }
151
+ }
152
+ if (v.outlier.test_biallelic) {
153
+ const tr = table.append("tr");
154
+ tr.append("td").attr("colspan", 2).text("Outlier (biallelic)");
155
+ const lst = [];
156
+ for (const k in v.outlier.test_biallelic) {
157
+ lst.push({ k, v: v.outlier.test_biallelic[k] });
158
+ }
159
+ const td = tr.append("td");
160
+ make_table_2col(td, lst);
161
+ if (v.outlier.test_biallelic.asehigh) {
162
+ td.append("div").style("background", cfg.outlier.color_outlier_asehigh).style("padding", "2px 10px").style("color", "white").text("ASE high");
163
+ }
164
+ }
165
+ if (v.outlier.test_entirecohort) {
166
+ const tr = table.append("tr");
167
+ tr.append("td").attr("colspan", 2).text("Outlier (all samples)");
168
+ const lst = [];
169
+ for (const k in v.outlier.test_entirecohort) {
170
+ lst.push({ k, v: v.outlier.test_entirecohort[k] });
171
+ }
172
+ const td = tr.append("td");
173
+ make_table_2col(td, lst);
174
+ if (v.outlier.test_entirecohort.asehigh) {
175
+ td.append("div").style("background", cfg.outlier.color_outlier_asehigh).style("padding", "2px 10px").style("color", "white").text("ASE high");
176
+ }
177
+ }
178
+ }
179
+ }
180
+ function ase_color(v, cfg) {
181
+ if (cfg.no_ase) return color_noinfo;
182
+ if (!cfg.ase) return color_noinfo;
183
+ if (!v.estat) return cfg.ase.color_noinfo;
184
+ if (v.estat.ase_monoallelic) return cfg.ase.color_monoallelic;
185
+ if (v.estat.ase_biallelic) return cfg.ase.color_biallelic;
186
+ if (v.estat.ase_uncertain) return cfg.ase.color_uncertain;
187
+ return cfg.ase.color_noinfo;
188
+ }
189
+ function ui_config(holder, cfg, tk, call) {
190
+ const indent = 30;
191
+ {
192
+ const row = holder.append("div").style("margin-bottom", "5px");
193
+ row.append("span").html("If " + (tk.checkrnabam ? "p-value geometric mean" : "Q-VALUE") + " &le;&nbsp;");
194
+ row.append("input").attr("type", "number").style("width", "50px").property("value", cfg.ase.qvalue).on("keyup", (event) => {
195
+ if (event.code != "Enter" && event.code != "NumpadEnter") return;
196
+ let v = Number.parseFloat(event.target.value);
197
+ if (!v || v <= 0) {
198
+ return;
199
+ }
200
+ if (cfg.ase.qvalue == v) {
201
+ return;
202
+ }
203
+ cfg.ase.qvalue = v;
204
+ call();
205
+ });
206
+ row.append("span").html("&nbsp;:");
207
+ }
208
+ {
209
+ const row = holder.append("div").style("margin", "0px 5px 5px " + indent + "px");
210
+ row.append("span").html("If MEAN_DELTA &ge;&nbsp;");
211
+ row.append("input").attr("type", "number").style("width", "50px").property("value", cfg.ase.meandelta_monoallelic).on("keyup", (event) => {
212
+ if (event.code != "Enter" && event.code != "NumpadEnter") return;
213
+ let v = Number.parseFloat(event.target.value);
214
+ if (!v || v <= 0) {
215
+ return;
216
+ }
217
+ if (cfg.ase.meandelta_monoallelic == v) {
218
+ return;
219
+ }
220
+ cfg.ase.meandelta_monoallelic = v;
221
+ call();
222
+ });
223
+ row.append("span").html("&nbsp;:&nbsp;");
224
+ }
225
+ holder.append("div").style("margin", "0px 5px 5px " + indent * 2 + "px").html(
226
+ 'Is <span style="background:' + cfg.ase.color_monoallelic + ';padding:1px 5px;color:white;">mono-allelic expression</span>'
227
+ );
228
+ holder.append("div").style("margin", "0px 5px 5px " + indent + "px").html("Else:");
229
+ holder.append("div").style("margin", "0px 5px 5px " + indent * 2 + "px").html(
230
+ 'Is <span style="background:' + cfg.ase.color_uncertain + ';padding:1px 5px;color:white;">ASE uncertain</span>'
231
+ );
232
+ holder.append("div").style("margin", "0px 5px 5px 0px").html("Else:");
233
+ {
234
+ const row = holder.append("div").style("margin", "0px 5px 5px " + indent + "px");
235
+ row.append("span").html("If number of ASE markers &le;&nbsp;");
236
+ row.append("input").attr("type", "number").style("width", "50px").property("value", cfg.ase.asemarkernumber_biallelic).on("keyup", (event) => {
237
+ if (event.code != "Enter" && event.code != "NumpadEnter") return;
238
+ let v = Number.parseInt(event.target.value);
239
+ if (v < 0) {
240
+ return;
241
+ }
242
+ if (cfg.ase.asemarkernumber_biallelic == v) {
243
+ return;
244
+ }
245
+ cfg.ase.asemarkernumber_biallelic = v;
246
+ call();
247
+ });
248
+ row.append("span").html("&nbsp;:&nbsp;");
249
+ }
250
+ holder.append("div").style("margin", "0px 5px 5px " + indent * 2 + "px").html(
251
+ 'Is <span style="background:' + cfg.ase.color_biallelic + ';padding:1px 5px;color:white;">bi-allelic expression</span>'
252
+ );
253
+ holder.append("div").style("margin", "0px 5px 5px " + indent + "px").html("Else:");
254
+ holder.append("div").style("margin", "0px 5px 5px " + indent * 2 + "px").html(
255
+ 'Is <span style="background:' + cfg.ase.color_uncertain + ';padding:1px 5px;color:white;">ASE uncertain</span>'
256
+ );
257
+ holder.append("div").style("margin", "10px").append("button").text("Default ASE parameters").on("click", () => {
258
+ cfg.ase.qvalue = 0.05;
259
+ cfg.ase.meandelta_monoallelic = 0.3;
260
+ cfg.ase.asemarkernumber_biallelic = 0;
261
+ call();
262
+ });
263
+ }
264
+
265
+ export {
266
+ init_config,
267
+ measure,
268
+ showsingleitem_table,
269
+ ase_color,
270
+ ui_config
271
+ };
272
+ //# sourceMappingURL=chunk-7FFTAYT4.js.map
@@ -0,0 +1,339 @@
1
+ import {
2
+ summaryInit
3
+ } from "./chunk-OI5KBFBE.js";
4
+ import {
5
+ navInit
6
+ } from "./chunk-J5GQGWYX.js";
7
+ import {
8
+ skipPrevActionAbort,
9
+ storeInit
10
+ } from "./chunk-YHWQWVWX.js";
11
+ import {
12
+ AppBase,
13
+ downloadSVGsAsPdf,
14
+ filterRxCompInit,
15
+ newSandboxDiv,
16
+ sayerror,
17
+ vocabInit
18
+ } from "./chunk-C3HEDQPT.js";
19
+ import {
20
+ importPlot
21
+ } from "./chunk-B6UXFX73.js";
22
+ import {
23
+ Menu
24
+ } from "./chunk-ELJX3QIQ.js";
25
+ import {
26
+ AppApi,
27
+ getCompInit,
28
+ multiInit
29
+ } from "./chunk-WINIL2KN.js";
30
+ import {
31
+ select_default
32
+ } from "./chunk-I6Y4O3RR.js";
33
+
34
+ // mass/plot.js
35
+ var MassPlot = class _MassPlot {
36
+ static type = "plot";
37
+ constructor(opts) {
38
+ this.type = _MassPlot.type;
39
+ setRenderers(this);
40
+ this.initUi(opts);
41
+ }
42
+ reactsTo(action) {
43
+ if (action.type.endsWith("_group")) return true;
44
+ if (action.type.startsWith("plot_")) {
45
+ return action.id === this.id || action.id == this.parentId || action.config?.parentId === this.id || action.parentId === this.id;
46
+ }
47
+ if (action.type.startsWith("filter")) return true;
48
+ if (action.type.startsWith("cohort")) return true;
49
+ if (action.type == "app_refresh") return true;
50
+ if (action.type.endsWith("customTerm")) return true;
51
+ }
52
+ // !!! NOTE: This getState() method is reused by the plot-specific recover component.
53
+ // When logging something within getState, it may have been called by either the plot or recover instance
54
+ getState(appState) {
55
+ const config = appState.plots.find((p) => p.id === this.id);
56
+ if (!config) {
57
+ throw `No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`;
58
+ }
59
+ return {
60
+ termfilter: appState.termfilter,
61
+ config,
62
+ groups: appState.groups,
63
+ // quick fix to skip history tracking as needed
64
+ _scope_: appState._scope_
65
+ };
66
+ }
67
+ async main() {
68
+ this.dom.errdiv.style("display", "none").style("background-color", "rgba(255,100,100,0.2)").html("");
69
+ if (!this.components) await this.setComponents(this.opts);
70
+ }
71
+ async setComponents(opts) {
72
+ const _ = await importPlot(opts.chartType);
73
+ const promises = {
74
+ // recover: recoverInit({
75
+ // app: this.app,
76
+ // holder: this.dom.localRecoverDiv,
77
+ // getState: appState => this.getState(appState),
78
+ // reactsTo: action =>
79
+ // action.id == this.id &&
80
+ // (action.type == 'plot_edit' || action.type == 'plot_nestedEdits') &&
81
+ // action._track_ != 'none',
82
+ // plot_id: this.id,
83
+ // maxHistoryLen: 10,
84
+ // hideLabel: true
85
+ // }),
86
+ chart: _.componentInit({
87
+ app: this.app,
88
+ holder: this.dom.viz,
89
+ header: this.dom.paneTitleDiv,
90
+ id: this.id,
91
+ plotDiv: select_default(this.dom.holder.app_div.node().parentNode),
92
+ /******* reason for passing plotDiv to chart ********
93
+ - this plot instance may allow to launch a new plot as a persistent sandbox
94
+ inside mass plotDiv, maintaining the uniform plot appearance despite it's ad-hoc
95
+ the new plot is not a formal mass plot type, and cannot be done via app.dispatch()
96
+ thus the need to directly access plotDiv
97
+ - example: mds3 tk from genome browser can launch disco etc
98
+ - having access to plotDiv may offer flexibility for the plot to do stuff
99
+
100
+ since plot.js has no access to mass app .dom.plotDiv in which all apps are shown,
101
+ this workarounds gets the parent node of sandbox.app_div which is app.dom.plotDiv
102
+ */
103
+ getFilterImage: async () => this.components.filter.getFilterImage()
104
+ })
105
+ };
106
+ if (!this.state.config.hidePlotFilter) {
107
+ const filterDisabledMsg = this.app.vocabApi.termdbConfig?.plotFilter?.disabledMessage;
108
+ const filterHolder = filterDisabledMsg ? this.dom.filterDiv.append("div").style("pointer-events", "none").style("opacity", 0.5) : this.dom.filterDiv;
109
+ if (filterDisabledMsg) this.dom.filterDiv.attr("title", filterDisabledMsg).style("cursor", "not-allowed");
110
+ promises.filter = filterRxCompInit({
111
+ app: this.app,
112
+ vocabApi: this.app.vocabApi,
113
+ parentId: this.id,
114
+ holder: filterHolder,
115
+ hideLabel: true,
116
+ emptyLabel: "+Add new filter",
117
+ callback: (filter) => {
118
+ this.app.dispatch({
119
+ id: this.id,
120
+ type: "plot_edit",
121
+ config: { filter }
122
+ });
123
+ }
124
+ });
125
+ }
126
+ this.components = await multiInit(promises);
127
+ }
128
+ destroy() {
129
+ this.dom.holder.app_div.selectAll("*").remove();
130
+ this.dom.holder.app_div.remove();
131
+ for (const key in this.dom) {
132
+ delete this.dom[key];
133
+ }
134
+ }
135
+ };
136
+ var plotInit = getCompInit(MassPlot);
137
+ function setRenderers(self) {
138
+ self.initUi = function(opts) {
139
+ const holder = opts.holder;
140
+ opts.holder.app_div.attr("data-testid", "sjpp-massplot-sandbox-" + opts.chartType);
141
+ holder.header.style("padding", 0);
142
+ try {
143
+ self.dom = {
144
+ tip: new Menu({ padding: "0px" }),
145
+ holder,
146
+ paneTitleDiv: holder.header.append("div").style("display", "inline-block").style("color", "#555").style("padding-left", "7px").style("vertical-align", "sub"),
147
+ localRecoverDiv: holder.header.append("div").style("display", "inline-block"),
148
+ filterDiv: holder.header.append("div").style("display", "inline-block").style("zoom", 0.9),
149
+ body: holder.body.style("white-space", "nowrap").style("overflow-x", "auto"),
150
+ // will hold no data notice or the page title in multichart views
151
+ errdiv: holder.body.append("div").style("display", "none").style("padding", "5px").style("background-color", "rgba(255,100,100,0.2)"),
152
+ // dom.viz will hold the rendered view
153
+ viz: holder.body.append("div")
154
+ };
155
+ } catch (e) {
156
+ self.dom.errdiv.style("display", "none").text(e);
157
+ }
158
+ };
159
+ }
160
+
161
+ // mass/app.ts
162
+ var MassApp = class extends AppBase {
163
+ // expected class-specific props
164
+ constructor(opts, api) {
165
+ super(opts);
166
+ this.components = {};
167
+ this.wasDestroyed = false;
168
+ this.api = api;
169
+ if (opts.addLoginCallback) {
170
+ opts.addLoginCallback(() => this.api.dispatch({ type: "app_refresh" }));
171
+ }
172
+ this.type = "app";
173
+ this.dom = {
174
+ holder: opts.holder,
175
+ // do not modify holder style
176
+ topbar: opts.holder.append("div"),
177
+ errdiv: opts.holder.append("div"),
178
+ plotDiv: opts.holder.append("div")
179
+ };
180
+ if (opts.getPlotConfig_mutateSummary) {
181
+ if (typeof opts.getPlotConfig_mutateSummary != "function")
182
+ throw new Error("opts.getPlotConfig_mutateSummary is not function");
183
+ }
184
+ this.plotIdToSandboxId = {};
185
+ }
186
+ static {
187
+ this.type = "app";
188
+ }
189
+ async preApiFreeze(api) {
190
+ try {
191
+ api.tip = new Menu({ padding: "5px" });
192
+ api.tip.d.on("keyup", (event) => {
193
+ if (event.key == "Escape") api.tip.hide();
194
+ });
195
+ api.printError = (e) => this.printError(e);
196
+ api.vocabApi = await vocabInit({
197
+ app: api,
198
+ state: { vocab: this.opts.state.vocab },
199
+ fetchOpts: this.opts.fetchOpts,
200
+ getDatasetAccessToken: this.opts.getDatasetAccessToken
201
+ });
202
+ api.hasWebGL = function() {
203
+ try {
204
+ const canvas = document.createElement("canvas");
205
+ return !!(window.WebGLRenderingContext && (canvas.getContext("webgl") || canvas.getContext("experimental-webgl")));
206
+ } catch (_) {
207
+ return false;
208
+ }
209
+ };
210
+ this.opts.state.vocab = api.vocabApi.vocab;
211
+ } catch (e) {
212
+ console.log(`preApiFreeze error`, e);
213
+ throw e;
214
+ }
215
+ }
216
+ async init() {
217
+ try {
218
+ const debounceInterval = "debounceInterval" in this.opts ? this.opts.debounceInterval : 0;
219
+ const embeddedSessionState = this.opts.embeddedSessionState;
220
+ if (embeddedSessionState) {
221
+ Object.assign(this.opts.state, embeddedSessionState);
222
+ }
223
+ this.store = await storeInit({ app: this.api, state: this.opts.state, debounceInterval });
224
+ this.state = await this.store.copyState();
225
+ this.components = {};
226
+ if (this.state.nav.header_mode != "hidden") {
227
+ this.components.nav = await navInit({
228
+ app: this.api,
229
+ holder: this.dom.topbar,
230
+ header_mode: this.state && this.state.nav && this.state.nav.header_mode,
231
+ vocab: this.state.vocab,
232
+ massSessionDuration: this.state.termdbConfig.massSessionDuration,
233
+ // this.opts.massSessionDuration
234
+ pkgver: this.opts.pkgver,
235
+ downloadPlots: () => {
236
+ this.downloadPlots();
237
+ }
238
+ });
239
+ }
240
+ this.components.plots = {};
241
+ if (this.opts.app?.doNotAwaitInitRender) {
242
+ this.api.dispatch();
243
+ } else {
244
+ await this.api.dispatch();
245
+ }
246
+ } catch (e) {
247
+ this.printError(e);
248
+ throw e;
249
+ }
250
+ }
251
+ async main() {
252
+ await this.api.vocabApi.main();
253
+ this.dom.plotDiv?.style(
254
+ "display",
255
+ this.state.nav?.header_mode != "hidden" && this.state.nav?.activeTab == 0 ? "none" : "block"
256
+ );
257
+ const newPlots = {};
258
+ let sandbox;
259
+ for (const plot of this.state.plots) {
260
+ if (plot.parentId) continue;
261
+ if (this.components.plots && !(plot.id in this.components.plots)) {
262
+ sandbox = newSandboxDiv(this.dom.plotDiv, {
263
+ close: () => {
264
+ this.api.dispatch({
265
+ type: "plot_delete",
266
+ id: plot.id
267
+ });
268
+ },
269
+ plotId: plot.id,
270
+ beforePlotId: plot.insertBefore || null,
271
+ style: {
272
+ width: "98.5%"
273
+ }
274
+ });
275
+ if (plot.chartType == "summary")
276
+ newPlots[plot.id] = summaryInit(Object.assign({ app: this.api, holder: sandbox }, plot));
277
+ else newPlots[plot.id] = plotInit(Object.assign({ app: this.api, holder: sandbox }, plot));
278
+ }
279
+ }
280
+ const numNewPlots = Object.keys(newPlots).length;
281
+ if (numNewPlots) {
282
+ await Promise.all(Object.values(newPlots));
283
+ for (const plotId in newPlots) {
284
+ this.components.plots[plotId] = await newPlots[plotId];
285
+ }
286
+ }
287
+ for (const plotId in this.components.plots) {
288
+ if (!this.state.plots.find((p) => p.id === plotId)) {
289
+ this.components.plots[plotId].destroy();
290
+ delete this.components.plots[plotId];
291
+ }
292
+ }
293
+ }
294
+ printError(e) {
295
+ const errdiv = e.errdiv || this.dom.errdiv;
296
+ if (errdiv) errdiv.style("display", "").html("").style("background-color", "");
297
+ sayerror(errdiv || this.opts.holder, "Error: " + (e.message || e.error || e));
298
+ if (e.stack) console.log(e.stack);
299
+ this.bus.emit("error");
300
+ if (this.opts?.debug) {
301
+ console.groupCollapsed("Stack trace from MassApp.printError() call.");
302
+ console.trace();
303
+ console.groupEnd();
304
+ }
305
+ }
306
+ skipPrevActionAbort(action) {
307
+ return skipPrevActionAbort(action);
308
+ }
309
+ async downloadPlots() {
310
+ const chartImagesAll = [];
311
+ let i = 1;
312
+ const values = Object.values(this.components.plots);
313
+ for (const plot of values) {
314
+ const chart = plot.type == "plot" ? plot.getComponents("chart") : plot;
315
+ const chartImages = chart.getChartImages ? chart.getChartImages() : null;
316
+ if (!chartImages) {
317
+ console.log(`The ${chart.type} does not support downloading images yet`);
318
+ continue;
319
+ }
320
+ for (const chartImage of chartImages) {
321
+ if (values.length > 1) chartImage.name = `${i}. ${chartImage.name}`;
322
+ chartImagesAll.push(chartImage);
323
+ }
324
+ i++;
325
+ }
326
+ if (chartImagesAll.length > 0) {
327
+ const filters = [];
328
+ const globalFilterImg = await this.components.nav.getComponents("filter").getFilterImage();
329
+ if (globalFilterImg) filters.push(globalFilterImg);
330
+ downloadSVGsAsPdf(chartImagesAll, "plots", "landscape", filters);
331
+ } else alert("No chart images available for download");
332
+ }
333
+ };
334
+ var appInit = AppApi.getInitFxn(MassApp);
335
+
336
+ export {
337
+ appInit
338
+ };
339
+ //# sourceMappingURL=chunk-7GDRMBNO.js.map