@sjcrh/proteinpaint-client 2.191.3 → 2.191.4

package/dist/brainImaging-65QDNR4D.js

@@ -0,0 +1,423 @@
+import {
+  controlsInit,
+  renderTable,
+  svgLegend,
+  term0_term2_defaultQ
+} from "./chunk-SA7APTJR.js";
+import "./chunk-HJ6L54YS.js";
+import "./chunk-LSEFWW72.js";
+import "./chunk-SKREEF3H.js";
+import {
+  Menu
+} from "./chunk-HYOEWQ5P.js";
+import "./chunk-HBW42TDT.js";
+import "./chunk-G6O3URDN.js";
+import "./chunk-FN5XPUPH.js";
+import "./chunk-IIT367QZ.js";
+import "./chunk-RZGEKL77.js";
+import "./chunk-UI7OCM2A.js";
+import "./chunk-YZK37YCC.js";
+import {
+  dofetch3
+} from "./chunk-7EMWHCVW.js";
+import "./chunk-7IYJZZQI.js";
+import {
+  copyMerge,
+  getCompInit
+} from "./chunk-M3J4MINX.js";
+import "./chunk-PF4DSFDR.js";
+import "./chunk-QH6W3NVF.js";
+import "./chunk-NOEAT6CX.js";
+import "./chunk-4UWS5Y3N.js";
+import "./chunk-DD4R5P6W.js";
+import "./chunk-JNITUVXP.js";
+import "./chunk-KSGA62R2.js";
+import "./chunk-LOZEKOES.js";
+import "./chunk-TOU7EVFQ.js";
+import {
+  linear
+} from "./chunk-OAWQ6LOO.js";
+import "./chunk-TLT4YIG3.js";
+import "./chunk-KYBIQBXE.js";
+import "./chunk-I6Y4O3RR.js";
+import {
+  rgb
+} from "./chunk-OMR2DT66.js";
+import "./chunk-DQC5FFGV.js";
+import "./chunk-HFNDKYVF.js";
+
+// plots/brainImaging.js
+var BrainImaging = class _BrainImaging {
+  static type = "brainImaging";
+  constructor(opts) {
+    this.opts = opts;
+    this.type = _BrainImaging.type;
+    setInteractivity(this);
+  }
+  async init(appState) {
+    const state = this.getState(appState);
+    const holder = this.opts.holder;
+    if (this.opts.header)
+      this.opts.header.style("padding-left", "7px").style("color", "rgb(85, 85, 85)").html(`Brain Imaging: ${state.config.queryKey}/${state.config.selectedSampleFileNames.join(" ")}`);
+    const controlsHolder = holder.append("div").style("display", "inline-block").style("vertical-align", "top");
+    const rightDiv = holder.append("div").style("display", "inline-block").style("vertical-align", "top");
+    const headerHolder = rightDiv.append("div").style("display", "inline-block").style("vertical-align", "top").style("padding", "10px");
+    const contentHolder = rightDiv.append("div").style("vertical-align", "top");
+    const table = contentHolder.append("table").style("border-collapse", "collapse");
+    const headerTr = table.append("tr");
+    const contentTr = table.append("tr").style("background-color", "black");
+    const tdL = contentTr.append("td");
+    const tdF = contentTr.append("td");
+    const tdT = contentTr.append("td");
+    const legendHolder = contentHolder.append("svg").style("width", "100%").on("mouseup", this.legendLabelMouseup);
+    const legendMenu = new Menu({ padding: "0px" });
+    this.dom = {
+      headerHolder,
+      contentHolder,
+      headerTr,
+      tdL,
+      tdF,
+      tdT,
+      legendHolder,
+      legendMenu
+    };
+    this.addSliders(state.config.settings.brainImaging);
+    const configInputsOptions = this.getConfigInputsOptions(state);
+    this.components = {
+      controls: await controlsInit({
+        app: this.app,
+        id: this.id,
+        holder: controlsHolder,
+        inputs: configInputsOptions
+      })
+    };
+    this.components.controls.on("downloadClick.brainImaging", () => {
+      const urls = [];
+      for (const key in this.imagesData)
+        for (const category in this.imagesData[key].dataUrls) {
+          const dataUrl = this.imagesData[key].dataUrls[category].url;
+          urls.push(dataUrl);
+        }
+      this.downloadImage(urls);
+    });
+    this.legendRenderer = svgLegend({ holder: this.dom.legendHolder });
+  }
+  addSliders(settings) {
+    const tr = this.dom.headerTr;
+    let td = tr.append("td");
+    td.append("label").attr("for", "saggital").text("Sagittal:");
+    this.dom.saggitalSlider = td.append("input").attr("id", "saggital").attr("type", "range").attr("min", 0).attr("max", 192).attr("value", settings.brainImageL).on("change", (e) => {
+      this.editBrainImage("brainImageL", e.target.value);
+    });
+    this.dom.saggitalInput = td.append("input").attr("type", "number").attr("min", 0).attr("max", 192).attr("value", settings.brainImageL).on("change", (e) => {
+      this.editBrainImage("brainImageL", e.target.value);
+    }).style("vertical-align", "top");
+    td = tr.append("td");
+    td.append("label").attr("for", "coronal").text("Coronal:");
+    this.dom.coronalSlider = td.append("input").attr("type", "range").attr("min", 0).attr("max", 228).attr("value", settings.brainImageF).on("change", (e) => {
+      this.editBrainImage("brainImageF", e.target.value);
+    });
+    this.dom.coronalInput = td.append("input").attr("type", "number").attr("min", 0).attr("max", 192).attr("value", settings.brainImageF).on("change", (e) => {
+      this.editBrainImage("brainImageF", e.target.value);
+    }).style("vertical-align", "top");
+    td = tr.append("td");
+    td.append("label").attr("for", "axial").text("Axial:");
+    this.dom.axialSlider = td.append("input").attr("id", "axial").attr("type", "range").attr("min", 0).attr("max", 192).attr("value", settings.brainImageT).on("change", (e) => {
+      this.editBrainImage("brainImageT", e.target.value);
+    });
+    this.dom.axialInput = td.append("input").attr("type", "number").attr("min", 0).attr("max", 192).attr("value", settings.brainImageT).on("change", (e) => {
+      this.editBrainImage("brainImageT", e.target.value);
+    });
+  }
+  editBrainImage(key, value) {
+    if (!value) return;
+    const settings = { [key]: Number(value) };
+    this.app.dispatch({ type: "plot_edit", id: this.id, config: { settings: { brainImaging: settings } } });
+  }
+  downloadImage(dataUrls) {
+    for (const dataUrl of dataUrls) {
+      const downloadImgName = "brainImaging";
+      const a = document.createElement("a");
+      document.body.appendChild(a);
+      a.addEventListener(
+        "click",
+        () => {
+          a.download = downloadImgName + ".png";
+          a.href = dataUrl;
+          document.body.removeChild(a);
+        },
+        false
+      );
+      a.click();
+    }
+  }
+  getConfigInputsOptions(state) {
+    if (state.config.selectedSampleFileNames.length == 1) return [];
+    const mandatoryConfigInputOptions = [
+      {
+        label: "Divide by",
+        type: "term",
+        chartType: "brainImaging",
+        configKey: "divideByTW",
+        title: "Categories to divide by",
+        usecase: { target: "brainImaging", detail: "term0" },
+        vocabApi: this.app.vocabApi,
+        numericEditMenuVersion: ["discrete"],
+        defaultQ4fillTW: term0_term2_defaultQ
+      },
+      {
+        label: "Color by",
+        type: "term",
+        chartType: "brainImaging",
+        configKey: "overlayTW",
+        title: "Categories to color the samples",
+        usecase: { target: "brainImaging", detail: "term2" },
+        vocabApi: this.app.vocabApi,
+        numericEditMenuVersion: ["discrete"],
+        defaultQ4fillTW: term0_term2_defaultQ
+      }
+    ];
+    return mandatoryConfigInputOptions;
+  }
+  getState(appState) {
+    const config = appState.plots.find((p) => p.id === this.id);
+    return {
+      config,
+      dslabel: appState.vocab.dslabel,
+      genome: appState.vocab.genome,
+      RefNIdata: appState.termdbConfig.queries.NIdata[config.queryKey]
+    };
+  }
+  async main() {
+    this.config = structuredClone(this.state.config);
+    this.settings = this.state.config.settings.brainImaging;
+    this.dom.saggitalSlider.property("value", this.settings.brainImageL);
+    this.dom.saggitalInput.property("value", this.settings.brainImageL);
+    this.dom.coronalSlider.property("value", this.settings.brainImageF);
+    this.dom.coronalInput.property("value", this.settings.brainImageF);
+    this.dom.axialSlider.property("value", this.settings.brainImageT);
+    this.dom.axialInput.property("value", this.settings.brainImageT);
+    const data = await Promise.all([
+      this.requestImage("l", this.settings.brainImageL),
+      this.requestImage("f", this.settings.brainImageF),
+      this.requestImage("t", this.settings.brainImageT)
+    ]);
+    this.imagesData = {
+      brainImageL: { dataUrls: {}, td: this.dom.tdL, data: data[0] },
+      brainImageF: { dataUrls: {}, td: this.dom.tdF, data: data[1] },
+      brainImageT: { dataUrls: {}, td: this.dom.tdT, data: data[2] }
+    };
+    for (const img of Object.values(this.imagesData)) this.renderImages(img);
+    this.renderLegend();
+  }
+  async requestImage(key, value) {
+    const body = {
+      genome: this.state.genome,
+      dslabel: this.state.dslabel,
+      refKey: this.state.config.queryKey,
+      [key]: value,
+      selectedSampleFileNames: this.state.config.selectedSampleFileNames,
+      divideByTW: this.state.config.divideByTW,
+      overlayTW: this.state.config.overlayTW,
+      legendFilter: this.state.config.legendFilter
+    };
+    return await dofetch3("brainImaging", { body });
+  }
+  renderImages({ data, td, dataUrls }) {
+    this.legendValues = data.legend;
+    if (data.error) throw data.error;
+    for (const [termV, result] of Object.entries(data.brainImage)) {
+      dataUrls[termV] = result;
+    }
+    td.selectAll("*").remove();
+    for (const [termV, result] of Object.entries(dataUrls)) {
+      if (this.state.config.divideByTW)
+        td.append("div").attr("class", "pp-chart-title").style("text-align", "center").text(`${termV} (n=${result.catNum})`).style("font-weight", "600").style("color", "white").style("font-size", "24px").style("margin-bottom", "5px").style("margin-top", "5px").style("display", "block");
+      td.append("div").append("img").attr("src", result.url);
+    }
+  }
+  renderLegend() {
+    const legendItems = [];
+    for (const [label, v] of Object.entries(this.legendValues)) {
+      const scale = linear(["white", v.color], [0, v.maxLength]).clamp(true);
+      legendItems.push({
+        text: label == "default" ? "Combined Intensity" : label,
+        width: 100,
+        scale,
+        colors: ["white", v.color],
+        domain: [0, v.maxLength],
+        key: label,
+        crossedOut: v.crossedOut
+      });
+    }
+    this.legendItems = legendItems;
+    const legendRendererData = [
+      {
+        items: legendItems
+      }
+    ];
+    this.legendRenderer(legendRendererData, {
+      settings: {
+        fontsize: 16,
+        iconh: 14,
+        iconw: 14,
+        dimensions: {
+          xOffset: 0
+        }
+      }
+    });
+  }
+};
+function makeChartBtnMenu(holder, chartsInstance) {
+  chartsInstance.dom.tip.clear();
+  const menuDiv = holder.append("div");
+  if (chartsInstance.state.termdbConfig.queries.NIdata) {
+    for (const [refKey, ref] of Object.entries(chartsInstance.state.termdbConfig.queries.NIdata)) {
+      const refDiv = menuDiv.append("div");
+      const refOption = refDiv.append("div").attr("class", "sja_menuoption sja_sharp_border").text(refKey).on("click", async () => {
+        refOption.attr("class", "sja_menuoption_not_interactive");
+        refOption.on("click", null);
+        const body = {
+          genome: chartsInstance.opts.vocab.genome,
+          dslabel: chartsInstance.opts.vocab.dslabel,
+          refKey,
+          samplesOnly: true
+        };
+        const result = await dofetch3("brainImagingSamples", { body });
+        const samples = result.samples;
+        const [rows, columns] = await getTableData(chartsInstance, samples, chartsInstance.state, refKey);
+        const applybt = {
+          text: "APPLY",
+          class: "sjpp_apply_btn sja_filter_tag_btn",
+          callback: (indexes) => {
+            chartsInstance.dom.tip.hide();
+            const selectedSampleFileNames = indexes.map((i) => samples[i].sample + ".nii");
+            const config = {
+              chartType: "brainImaging",
+              queryKey: refKey,
+              settings: {
+                brainImaging: {
+                  brainImageL: ref.parameters.l,
+                  brainImageF: ref.parameters.f,
+                  brainImageT: ref.parameters.t
+                }
+              },
+              selectedSampleFileNames
+            };
+            chartsInstance.app.dispatch({
+              type: "plot_create",
+              config
+            });
+          }
+        };
+        renderTable({
+          rows,
+          columns,
+          resize: true,
+          singleMode: false,
+          div: refDiv.append("div"),
+          maxHeight: "40vh",
+          buttons: [applybt]
+        });
+      });
+    }
+  }
+}
+var brainImaging = getCompInit(BrainImaging);
+var componentInit = brainImaging;
+async function getPlotConfig(opts) {
+  const settings = {
+    brainImaging: { brainImageL: 76, brainImageF: 116, brainImageT: 80 }
+  };
+  const config = { chartType: "brainImaging", settings, hidePlotFilter: true };
+  return copyMerge(config, opts);
+}
+async function getTableData(self, samples, state, refKey) {
+  const rows = [];
+  for (const sample of samples) {
+    const row = [{ value: sample.sample }];
+    for (const c of state.termdbConfig.queries.NIdata[refKey].sampleColumns || []) {
+      row.push({ value: sample[c.termid] });
+    }
+    rows.push(row);
+  }
+  const columns = [{ label: "Sample" }];
+  for (const c of state.termdbConfig.queries.NIdata[refKey].sampleColumns || []) {
+    columns.push({
+      label: (await self.app.vocabApi.getterm(c.termid)).name
+    });
+  }
+  return [rows, columns];
+}
+function setInteractivity(self) {
+  self.legendLabelMouseup = (event) => {
+    const targetData = event.target.__data__;
+    if (!targetData || targetData.key == "default") return;
+    const legendMenu = self.dom.legendMenu.clear();
+    const legendMenuDiv = legendMenu.d.append("div");
+    const legendFilter = self.state.config.legendFilter ? [...self.state.config.legendFilter] : [];
+    const legendFilterIndex = legendFilter.indexOf(targetData.key);
+    if (legendFilterIndex !== -1 || legendFilter.length + 1 !== self.legendItems.length) {
+      legendMenuDiv.append("div").attr("class", "sja_menuoption sja_sharp_border").text(legendFilterIndex == -1 ? "Hide" : "Show").on("click", () => {
+        legendMenu.hide();
+        if (legendFilterIndex == -1) legendFilter.push(targetData.key);
+        else legendFilter.splice(legendFilterIndex, 1);
+        self.app.dispatch({
+          type: "plot_edit",
+          id: self.id,
+          config: { legendFilter }
+        });
+      });
+    }
+    legendMenuDiv.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Show only").on("click", () => {
+      legendMenu.hide();
+      const legendFilter2 = [];
+      for (const legendCat of self.legendItems) {
+        if (legendCat.key !== targetData.key) legendFilter2.push(legendCat.key);
+      }
+      self.app.dispatch({
+        type: "plot_edit",
+        id: self.id,
+        config: { legendFilter: legendFilter2 }
+      });
+    });
+    legendMenuDiv.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Show all").on("click", () => {
+      legendMenu.hide();
+      self.app.dispatch({
+        type: "plot_edit",
+        id: self.id,
+        config: { legendFilter: [] }
+      });
+    });
+    if (self.state.config.overlayTW.term.type != "geneVariant") {
+      let color = self.state.config.overlayTW?.term?.values?.[targetData.key]?.color || "red";
+      color = rgb(color).formatHex();
+      legendMenuDiv.append("div").attr("class", "sja_sharp_border").style("padding", "0px 10px").text("Color:").append("input").attr("type", "color").attr("value", color).on("change", (e) => {
+        self.changeColor(targetData.key, e.target.value);
+      });
+    }
+    legendMenu.showunder(event.target);
+  };
+  self.changeColor = async function(key, color) {
+    const tw = self.config.overlayTW;
+    if (!(tw.term.type == "geneVariant" && tw.q.type == "values") && tw.term.values[key])
+      tw.term.values[key].color = color;
+    else {
+      if (!tw.term.values) tw.term.values = {};
+      if (!tw.term.values[key]) tw.term.values[key] = {};
+      tw.term.values[key].color = color;
+    }
+    await self.app.dispatch({
+      type: "plot_edit",
+      id: self.id,
+      config: { overlayTW: tw }
+    });
+  };
+}
+export {
+  brainImaging,
+  componentInit,
+  getPlotConfig,
+  makeChartBtnMenu
+};
+//# sourceMappingURL=brainImaging-65QDNR4D.js.map

package/dist/chunk-2XCUERHJ.js

@@ -0,0 +1,102 @@
+import {
+  addGeneSearchbox,
+  first_genetrack_tolist,
+  getDNAMethUnit,
+  sayerror
+} from "./chunk-SA7APTJR.js";
+import {
+  Menu
+} from "./chunk-HYOEWQ5P.js";
+import {
+  DNA_METHYLATION
+} from "./chunk-NOEAT6CX.js";
+
+// termdb/handlers/dnaMethylation.ts
+var SearchHandler = class {
+  init(opts) {
+    this.opts = opts;
+    this.callback = opts.callback;
+    this.app = opts.app;
+    const holder = opts.holder.append("div").style("margin", "10px 0px");
+    this.dom = {};
+    this.dom.errDiv = holder.append("div").style("margin", "5px 0px").style("display", "none");
+    this.dom.geneSearchDiv = holder.append("div");
+    this.dom.blockDiv = holder.append("div").style("display", "none").style("margin", "15px 4px");
+    const geneSearch = addGeneSearchbox({
+      tip: new Menu({ padding: "0px" }),
+      genome: opts.genomeObj,
+      row: this.dom.geneSearchDiv,
+      callback: async () => {
+        try {
+          this.dom.errDiv.style("display", "none");
+          await this.handleGeneSearch(geneSearch);
+        } catch (e) {
+          this.dom.errDiv.style("display", "block");
+          sayerror(this.dom.errDiv, "Error: " + (e.message || e));
+          if (e.stack) console.log(e.stack);
+        }
+      }
+    });
+  }
+  async handleGeneSearch(geneSearch) {
+    if (geneSearch.geneSymbol) {
+      const { chr, start, stop } = geneSearch;
+      if (!chr || !Number.isInteger(start) || !Number.isInteger(stop))
+        throw new Error("unable to retrieve gene coordinate");
+      this.dom.blockDiv.selectAll("*").remove();
+      this.dom.blockDiv.style("display", "block");
+      this.dom.blockDiv.append("div").style("opacity", 0.6).text("Navigate genome browser to desired region");
+      const arg = {
+        holder: this.dom.blockDiv,
+        genome: this.opts.genomeObj,
+        // genome obj
+        chr,
+        start,
+        stop,
+        tklst: [],
+        nobox: true,
+        width: 500,
+        hidegenelegend: true,
+        debugmode: this.opts.debug
+      };
+      first_genetrack_tolist(this.opts.genomeObj, arg.tklst);
+      const _ = await import("./block-TTN2IQAH.js");
+      this.blockInstance = new _.Block(arg);
+      this.dom.submitBtn = this.dom.blockDiv.append("div").attr("data-testid", "sjpp-dnaMethylation-submitDiv").style("margin", "10px 0px").append("button").style("border", "none").style("border-radius", "20px").style("padding", "10px 15px").text("Submit Region").on("click", async () => {
+        const { chr: chr2, start: start2, stop: stop2 } = this.blockInstance.rglst[0];
+        const term = this.makeTerm({ chr: chr2, start: start2, stop: stop2 });
+        await this.callback(term);
+      });
+    } else if (geneSearch.chr && Number.isInteger(geneSearch.start) && Number.isInteger(geneSearch.stop)) {
+      const { chr } = geneSearch;
+      let { start, stop } = geneSearch;
+      if (geneSearch.actualposition?.len <= 1) {
+        start = geneSearch.actualposition.position;
+        stop = start + 1;
+      }
+      const term = this.makeTerm({ chr, start, stop });
+      await this.callback(term);
+    } else {
+      throw new Error("invalid gene search input");
+    }
+  }
+  makeTerm(opts) {
+    const { chr, start, stop } = opts;
+    if (!chr || !Number.isInteger(start) || !Number.isInteger(stop)) throw new Error("invalid coordinate");
+    const unit = getDNAMethUnit("region", this.app.vocabApi);
+    const term = {
+      chr,
+      start,
+      stop,
+      type: DNA_METHYLATION,
+      unit,
+      genomicFeatureType: "region"
+    };
+    return term;
+  }
+};
+
+export {
+  SearchHandler
+};
+//# sourceMappingURL=chunk-2XCUERHJ.js.map