@sjcrh/proteinpaint-client 2.182.0 → 2.183.0

package/dist/brainImaging-VSOOMITW.js

@@ -0,0 +1,421 @@
+import {
+  controlsInit,
+  renderTable,
+  svgLegend,
+  term0_term2_defaultQ
+} from "./chunk-OXJ2TWDO.js";
+import "./chunk-HJ6L54YS.js";
+import "./chunk-V6DLLX4N.js";
+import {
+  dofetch3
+} from "./chunk-7RN3L2BX.js";
+import {
+  Menu
+} from "./chunk-A6TQGNDQ.js";
+import "./chunk-HYZG6OPC.js";
+import "./chunk-FN5XPUPH.js";
+import "./chunk-LSEFWW72.js";
+import "./chunk-5EF5U7MX.js";
+import "./chunk-2K5DSRBJ.js";
+import "./chunk-UCLS2SVB.js";
+import {
+  copyMerge,
+  getCompInit
+} from "./chunk-MVTCBVSX.js";
+import "./chunk-SEQLC4AD.js";
+import "./chunk-L4QG7XZE.js";
+import "./chunk-DQC5FFGV.js";
+import "./chunk-KQMEJUWI.js";
+import "./chunk-UJU3Q7QJ.js";
+import "./chunk-WGL6FIUE.js";
+import "./chunk-6ITDJ5UR.js";
+import "./chunk-XYFDBYOY.js";
+import "./chunk-TV74I3Y5.js";
+import "./chunk-IH7ILDJS.js";
+import "./chunk-LOZEKOES.js";
+import "./chunk-TOU7EVFQ.js";
+import {
+  linear
+} from "./chunk-OAWQ6LOO.js";
+import "./chunk-SEEYV6P2.js";
+import "./chunk-NDWTN4U5.js";
+import {
+  rgb
+} from "./chunk-OMR2DT66.js";
+import "./chunk-HFNDKYVF.js";
+
+// plots/brainImaging.js
+var BrainImaging = class _BrainImaging {
+  static type = "brainImaging";
+  constructor(opts) {
+    this.opts = opts;
+    this.type = _BrainImaging.type;
+    setInteractivity(this);
+  }
+  async init(appState) {
+    const state = this.getState(appState);
+    const holder = this.opts.holder;
+    if (this.opts.header)
+      this.opts.header.style("padding-left", "7px").style("color", "rgb(85, 85, 85)").html(`Brain Imaging: ${state.config.queryKey}/${state.config.selectedSampleFileNames.join(" ")}`);
+    const controlsHolder = holder.append("div").style("display", "inline-block").style("vertical-align", "top");
+    const rightDiv = holder.append("div").style("display", "inline-block").style("vertical-align", "top");
+    const headerHolder = rightDiv.append("div").style("display", "inline-block").style("vertical-align", "top").style("padding", "10px");
+    const contentHolder = rightDiv.append("div").style("vertical-align", "top");
+    const table = contentHolder.append("table").style("border-collapse", "collapse");
+    const headerTr = table.append("tr");
+    const contentTr = table.append("tr").style("background-color", "black");
+    const tdL = contentTr.append("td");
+    const tdF = contentTr.append("td");
+    const tdT = contentTr.append("td");
+    const legendHolder = contentHolder.append("svg").style("width", "100%").on("mouseup", this.legendLabelMouseup);
+    const legendMenu = new Menu({ padding: "0px" });
+    this.dom = {
+      headerHolder,
+      contentHolder,
+      headerTr,
+      tdL,
+      tdF,
+      tdT,
+      legendHolder,
+      legendMenu
+    };
+    this.addSliders(state.config.settings.brainImaging);
+    const configInputsOptions = this.getConfigInputsOptions(state);
+    this.components = {
+      controls: await controlsInit({
+        app: this.app,
+        id: this.id,
+        holder: controlsHolder,
+        inputs: configInputsOptions
+      })
+    };
+    this.components.controls.on("downloadClick.brainImaging", () => {
+      const urls = [];
+      for (const key in this.imagesData)
+        for (const category in this.imagesData[key].dataUrls) {
+          const dataUrl = this.imagesData[key].dataUrls[category].url;
+          urls.push(dataUrl);
+        }
+      this.downloadImage(urls);
+    });
+    this.legendRenderer = svgLegend({ holder: this.dom.legendHolder });
+  }
+  addSliders(settings) {
+    const tr = this.dom.headerTr;
+    let td = tr.append("td");
+    td.append("label").attr("for", "saggital").text("Sagittal:");
+    this.dom.saggitalSlider = td.append("input").attr("id", "saggital").attr("type", "range").attr("min", 0).attr("max", 192).attr("value", settings.brainImageL).on("change", (e) => {
+      this.editBrainImage("brainImageL", e.target.value);
+    });
+    this.dom.saggitalInput = td.append("input").attr("type", "number").attr("min", 0).attr("max", 192).attr("value", settings.brainImageL).on("change", (e) => {
+      this.editBrainImage("brainImageL", e.target.value);
+    }).style("vertical-align", "top");
+    td = tr.append("td");
+    td.append("label").attr("for", "coronal").text("Coronal:");
+    this.dom.coronalSlider = td.append("input").attr("type", "range").attr("min", 0).attr("max", 228).attr("value", settings.brainImageF).on("change", (e) => {
+      this.editBrainImage("brainImageF", e.target.value);
+    });
+    this.dom.coronalInput = td.append("input").attr("type", "number").attr("min", 0).attr("max", 192).attr("value", settings.brainImageF).on("change", (e) => {
+      this.editBrainImage("brainImageF", e.target.value);
+    }).style("vertical-align", "top");
+    td = tr.append("td");
+    td.append("label").attr("for", "axial").text("Axial:");
+    this.dom.axialSlider = td.append("input").attr("id", "axial").attr("type", "range").attr("min", 0).attr("max", 192).attr("value", settings.brainImageT).on("change", (e) => {
+      this.editBrainImage("brainImageT", e.target.value);
+    });
+    this.dom.axialInput = td.append("input").attr("type", "number").attr("min", 0).attr("max", 192).attr("value", settings.brainImageT).on("change", (e) => {
+      this.editBrainImage("brainImageT", e.target.value);
+    });
+  }
+  editBrainImage(key, value) {
+    if (!value) return;
+    const settings = { [key]: Number(value) };
+    this.app.dispatch({ type: "plot_edit", id: this.id, config: { settings: { brainImaging: settings } } });
+  }
+  downloadImage(dataUrls) {
+    for (const dataUrl of dataUrls) {
+      const downloadImgName = "brainImaging";
+      const a = document.createElement("a");
+      document.body.appendChild(a);
+      a.addEventListener(
+        "click",
+        () => {
+          a.download = downloadImgName + ".png";
+          a.href = dataUrl;
+          document.body.removeChild(a);
+        },
+        false
+      );
+      a.click();
+    }
+  }
+  getConfigInputsOptions(state) {
+    if (state.config.selectedSampleFileNames.length == 1) return [];
+    const mandatoryConfigInputOptions = [
+      {
+        label: "Divide by",
+        type: "term",
+        chartType: "brainImaging",
+        configKey: "divideByTW",
+        title: "Categories to divide by",
+        usecase: { target: "brainImaging", detail: "term0" },
+        vocabApi: this.app.vocabApi,
+        numericEditMenuVersion: ["discrete"],
+        defaultQ4fillTW: term0_term2_defaultQ
+      },
+      {
+        label: "Color by",
+        type: "term",
+        chartType: "brainImaging",
+        configKey: "overlayTW",
+        title: "Categories to color the samples",
+        usecase: { target: "brainImaging", detail: "term2" },
+        vocabApi: this.app.vocabApi,
+        numericEditMenuVersion: ["discrete"],
+        defaultQ4fillTW: term0_term2_defaultQ
+      }
+    ];
+    return mandatoryConfigInputOptions;
+  }
+  getState(appState) {
+    const config = appState.plots.find((p) => p.id === this.id);
+    return {
+      config,
+      dslabel: appState.vocab.dslabel,
+      genome: appState.vocab.genome,
+      RefNIdata: appState.termdbConfig.queries.NIdata[config.queryKey]
+    };
+  }
+  async main() {
+    this.config = structuredClone(this.state.config);
+    this.settings = this.state.config.settings.brainImaging;
+    this.dom.saggitalSlider.property("value", this.settings.brainImageL);
+    this.dom.saggitalInput.property("value", this.settings.brainImageL);
+    this.dom.coronalSlider.property("value", this.settings.brainImageF);
+    this.dom.coronalInput.property("value", this.settings.brainImageF);
+    this.dom.axialSlider.property("value", this.settings.brainImageT);
+    this.dom.axialInput.property("value", this.settings.brainImageT);
+    const data = await Promise.all([
+      this.requestImage("l", this.settings.brainImageL),
+      this.requestImage("f", this.settings.brainImageF),
+      this.requestImage("t", this.settings.brainImageT)
+    ]);
+    this.imagesData = {
+      brainImageL: { dataUrls: {}, td: this.dom.tdL, data: data[0] },
+      brainImageF: { dataUrls: {}, td: this.dom.tdF, data: data[1] },
+      brainImageT: { dataUrls: {}, td: this.dom.tdT, data: data[2] }
+    };
+    for (const img of Object.values(this.imagesData)) this.renderImages(img);
+    this.renderLegend();
+  }
+  async requestImage(key, value) {
+    const body = {
+      genome: this.state.genome,
+      dslabel: this.state.dslabel,
+      refKey: this.state.config.queryKey,
+      [key]: value,
+      selectedSampleFileNames: this.state.config.selectedSampleFileNames,
+      divideByTW: this.state.config.divideByTW,
+      overlayTW: this.state.config.overlayTW,
+      legendFilter: this.state.config.legendFilter
+    };
+    return await dofetch3("brainImaging", { body });
+  }
+  renderImages({ data, td, dataUrls }) {
+    this.legendValues = data.legend;
+    if (data.error) throw data.error;
+    for (const [termV, result] of Object.entries(data.brainImage)) {
+      dataUrls[termV] = result;
+    }
+    td.selectAll("*").remove();
+    for (const [termV, result] of Object.entries(dataUrls)) {
+      if (this.state.config.divideByTW)
+        td.append("div").attr("class", "pp-chart-title").style("text-align", "center").text(`${termV} (n=${result.catNum})`).style("font-weight", "600").style("color", "white").style("font-size", "24px").style("margin-bottom", "5px").style("margin-top", "5px").style("display", "block");
+      td.append("div").append("img").attr("src", result.url);
+    }
+  }
+  renderLegend() {
+    const legendItems = [];
+    for (const [label, v] of Object.entries(this.legendValues)) {
+      const scale = linear(["white", v.color], [0, v.maxLength]).clamp(true);
+      legendItems.push({
+        text: label == "default" ? "Combined Intensity" : label,
+        width: 100,
+        scale,
+        colors: ["white", v.color],
+        domain: [0, v.maxLength],
+        key: label,
+        crossedOut: v.crossedOut
+      });
+    }
+    this.legendItems = legendItems;
+    const legendRendererData = [
+      {
+        items: legendItems
+      }
+    ];
+    this.legendRenderer(legendRendererData, {
+      settings: {
+        fontsize: 16,
+        iconh: 14,
+        iconw: 14,
+        dimensions: {
+          xOffset: 0
+        }
+      }
+    });
+  }
+};
+function makeChartBtnMenu(holder, chartsInstance) {
+  chartsInstance.dom.tip.clear();
+  const menuDiv = holder.append("div");
+  if (chartsInstance.state.termdbConfig.queries.NIdata) {
+    for (const [refKey, ref] of Object.entries(chartsInstance.state.termdbConfig.queries.NIdata)) {
+      const refDiv = menuDiv.append("div");
+      const refOption = refDiv.append("div").attr("class", "sja_menuoption sja_sharp_border").text(refKey).on("click", async () => {
+        refOption.attr("class", "sja_menuoption_not_interactive");
+        refOption.on("click", null);
+        const body = {
+          genome: chartsInstance.opts.vocab.genome,
+          dslabel: chartsInstance.opts.vocab.dslabel,
+          refKey,
+          samplesOnly: true
+        };
+        const result = await dofetch3("brainImagingSamples", { body });
+        const samples = result.samples;
+        const [rows, columns] = await getTableData(chartsInstance, samples, chartsInstance.state, refKey);
+        const applybt = {
+          text: "APPLY",
+          class: "sjpp_apply_btn sja_filter_tag_btn",
+          callback: (indexes) => {
+            chartsInstance.dom.tip.hide();
+            const selectedSampleFileNames = indexes.map((i) => samples[i].sample + ".nii");
+            const config = {
+              chartType: "brainImaging",
+              queryKey: refKey,
+              settings: {
+                brainImaging: {
+                  brainImageL: ref.parameters.l,
+                  brainImageF: ref.parameters.f,
+                  brainImageT: ref.parameters.t
+                }
+              },
+              selectedSampleFileNames
+            };
+            chartsInstance.app.dispatch({
+              type: "plot_create",
+              config
+            });
+          }
+        };
+        renderTable({
+          rows,
+          columns,
+          resize: true,
+          singleMode: false,
+          div: refDiv.append("div"),
+          maxHeight: "40vh",
+          buttons: [applybt]
+        });
+      });
+    }
+  }
+}
+var brainImaging = getCompInit(BrainImaging);
+var componentInit = brainImaging;
+async function getPlotConfig(opts) {
+  const settings = {
+    brainImaging: { brainImageL: 76, brainImageF: 116, brainImageT: 80 }
+  };
+  const config = { chartType: "brainImaging", settings, hidePlotFilter: true };
+  return copyMerge(config, opts);
+}
+async function getTableData(self, samples, state, refKey) {
+  const rows = [];
+  for (const sample of samples) {
+    const row = [{ value: sample.sample }];
+    for (const c of state.termdbConfig.queries.NIdata[refKey].sampleColumns || []) {
+      row.push({ value: sample[c.termid] });
+    }
+    rows.push(row);
+  }
+  const columns = [{ label: "Sample" }];
+  for (const c of state.termdbConfig.queries.NIdata[refKey].sampleColumns || []) {
+    columns.push({
+      label: (await self.app.vocabApi.getterm(c.termid)).name
+    });
+  }
+  return [rows, columns];
+}
+function setInteractivity(self) {
+  self.legendLabelMouseup = (event) => {
+    const targetData = event.target.__data__;
+    if (!targetData || targetData.key == "default") return;
+    const legendMenu = self.dom.legendMenu.clear();
+    const legendMenuDiv = legendMenu.d.append("div");
+    const legendFilter = self.state.config.legendFilter ? [...self.state.config.legendFilter] : [];
+    const legendFilterIndex = legendFilter.indexOf(targetData.key);
+    if (legendFilterIndex !== -1 || legendFilter.length + 1 !== self.legendItems.length) {
+      legendMenuDiv.append("div").attr("class", "sja_menuoption sja_sharp_border").text(legendFilterIndex == -1 ? "Hide" : "Show").on("click", () => {
+        legendMenu.hide();
+        if (legendFilterIndex == -1) legendFilter.push(targetData.key);
+        else legendFilter.splice(legendFilterIndex, 1);
+        self.app.dispatch({
+          type: "plot_edit",
+          id: self.id,
+          config: { legendFilter }
+        });
+      });
+    }
+    legendMenuDiv.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Show only").on("click", () => {
+      legendMenu.hide();
+      const legendFilter2 = [];
+      for (const legendCat of self.legendItems) {
+        if (legendCat.key !== targetData.key) legendFilter2.push(legendCat.key);
+      }
+      self.app.dispatch({
+        type: "plot_edit",
+        id: self.id,
+        config: { legendFilter: legendFilter2 }
+      });
+    });
+    legendMenuDiv.append("div").attr("class", "sja_menuoption sja_sharp_border").text("Show all").on("click", () => {
+      legendMenu.hide();
+      self.app.dispatch({
+        type: "plot_edit",
+        id: self.id,
+        config: { legendFilter: [] }
+      });
+    });
+    if (self.state.config.overlayTW.term.type != "geneVariant") {
+      let color = self.state.config.overlayTW?.term?.values?.[targetData.key]?.color || "red";
+      color = rgb(color).formatHex();
+      legendMenuDiv.append("div").attr("class", "sja_sharp_border").style("padding", "0px 10px").text("Color:").append("input").attr("type", "color").attr("value", color).on("change", (e) => {
+        self.changeColor(targetData.key, e.target.value);
+      });
+    }
+    legendMenu.showunder(event.target);
+  };
+  self.changeColor = async function(key, color) {
+    const tw = self.config.overlayTW;
+    if (!(tw.term.type == "geneVariant" && tw.q.type == "values") && tw.term.values[key])
+      tw.term.values[key].color = color;
+    else {
+      if (!tw.term.values) tw.term.values = {};
+      if (!tw.term.values[key]) tw.term.values[key] = {};
+      tw.term.values[key].color = color;
+    }
+    await self.app.dispatch({
+      type: "plot_edit",
+      id: self.id,
+      config: { overlayTW: tw }
+    });
+  };
+}
+export {
+  brainImaging,
+  componentInit,
+  getPlotConfig,
+  makeChartBtnMenu
+};
+//# sourceMappingURL=brainImaging-VSOOMITW.js.map

package/dist/chat-LW23PIG5.js

@@ -0,0 +1,148 @@
+import {
+  getId
+} from "./chunk-VUUZJANK.js";
+import "./chunk-HZETQJGD.js";
+import "./chunk-PRZWSBMA.js";
+import {
+  PlotBase,
+  keyupEnter
+} from "./chunk-OXJ2TWDO.js";
+import "./chunk-HJ6L54YS.js";
+import "./chunk-V6DLLX4N.js";
+import {
+  dofetch3
+} from "./chunk-7RN3L2BX.js";
+import {
+  Menu
+} from "./chunk-A6TQGNDQ.js";
+import "./chunk-HYZG6OPC.js";
+import "./chunk-FN5XPUPH.js";
+import "./chunk-LSEFWW72.js";
+import "./chunk-5EF5U7MX.js";
+import "./chunk-2K5DSRBJ.js";
+import "./chunk-UCLS2SVB.js";
+import {
+  copyMerge,
+  getCompInit
+} from "./chunk-MVTCBVSX.js";
+import "./chunk-SEQLC4AD.js";
+import "./chunk-L4QG7XZE.js";
+import "./chunk-DQC5FFGV.js";
+import "./chunk-KQMEJUWI.js";
+import "./chunk-UJU3Q7QJ.js";
+import "./chunk-WGL6FIUE.js";
+import "./chunk-6ITDJ5UR.js";
+import "./chunk-XYFDBYOY.js";
+import "./chunk-TV74I3Y5.js";
+import "./chunk-IH7ILDJS.js";
+import "./chunk-LOZEKOES.js";
+import "./chunk-TOU7EVFQ.js";
+import "./chunk-OAWQ6LOO.js";
+import "./chunk-SEEYV6P2.js";
+import "./chunk-NDWTN4U5.js";
+import "./chunk-OMR2DT66.js";
+import "./chunk-HFNDKYVF.js";
+
+// plots/chat/chat.ts
+var Chat = class extends PlotBase {
+  constructor(opts, api) {
+    super(opts, api);
+    this.type = "chat";
+    this.opts = opts;
+    this.components = {
+      controls: {}
+    };
+    this.initUi(opts);
+  }
+  static {
+    this.type = "chat";
+  }
+  getState(appState) {
+    const config = appState.plots.find((p) => p.id === this.id);
+    if (!config) {
+      throw `No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`;
+    }
+    return {};
+  }
+  //async init(appState: MassState) {}
+  async main() {
+  }
+  initUi(opts) {
+    const holder = opts.holder.classed("sjpp-chat-main", true);
+    const div = holder.append("div").style("padding", "5px").style("display", "inline-block");
+    this.dom = {
+      tip: new Menu({ padding: "" }),
+      div,
+      // error div on top
+      error: div.append("div").attr("id", "sjpp-corrVolcano-error").style("opacity", 0.75),
+      // div with bubbles to show chat history
+      bubbleDiv: div.append("div").attr("class", "sjpp_show_scrollbar").style("margin", "5px 20px 0px 20px").style("height", "200px").style("overflow", "auto").style("scroll-behavior", "smooth")
+    };
+    if (opts.header) {
+      this.dom.header = opts.header.text("CHAT").style("opacity", 0.7);
+    }
+    div.append("input").style("margin", "15px").style("padding", "17px").style("border-radius", "34px").attr("size", 70).attr("placeholder", "What are you looking for?").on("keyup", async (event) => {
+      if (!keyupEnter(event)) return;
+      const prompt = event.target.value.trim();
+      if (!prompt) return;
+      if (prompt.length < 5) return;
+      this.addBubble({ msg: prompt, me: 1 });
+      const body = {
+        genome: this.app.vocabApi.vocab.genome,
+        dslabel: this.app.vocabApi.vocab.dslabel,
+        filter: this.app.vocabApi.state.termfilter?.filter,
+        prompt
+      };
+      event.target.value = "";
+      const serverBubble = this.addBubble({ msg: "..." });
+      try {
+        const data = await dofetch3("termdb/chat2", { body });
+        if (data.error) throw data.error;
+        console.log(data);
+        const result = data;
+        if (result.type == "text") {
+          serverBubble.text(result.text);
+        } else if (result.type == "html") {
+          serverBubble.html(result.html);
+        } else if (result.type == "plot") {
+          const newPlotId = getId();
+          this.app.dispatch({
+            type: "plot_create",
+            id: newPlotId,
+            config: result.plot
+          });
+          serverBubble.html("Please refer to the plot generated above");
+        }
+      } catch (e) {
+        if (e.stack) console.log(e.stack);
+        serverBubble.html(`Error: ${e.message || e}`);
+      }
+    }).node().focus();
+  }
+  addBubble(arg) {
+    const bubble = this.dom.bubbleDiv.append("div").style("padding", "10px").html(`${arg.me ? '<span style="font-size:.7em">[ME]</span> ' : ""}${arg.msg}`);
+    if (arg.me) bubble.style("background", "#f1f1f1");
+    const n = this.dom.bubbleDiv.node();
+    n.scrollTop = n.scrollHeight;
+    return bubble;
+  }
+};
+var chatInit = getCompInit(Chat);
+var componentInit = chatInit;
+async function getPlotConfig(opts) {
+  const config = {
+    chartType: "chat"
+  };
+  return copyMerge(config, opts);
+}
+function makeChartBtnMenu(_holder, chartsInstance) {
+  const chart = { config: { chartType: "chat" } };
+  chartsInstance.prepPlot(chart);
+}
+export {
+  chatInit,
+  componentInit,
+  getPlotConfig,
+  makeChartBtnMenu
+};
+//# sourceMappingURL=chat-LW23PIG5.js.map

package/dist/chunk-2A2KM5DU.js

@@ -0,0 +1,117 @@
+import {
+  addGeneSearchbox,
+  isoformSelect,
+  sayerror
+} from "./chunk-OXJ2TWDO.js";
+import {
+  dofetch3
+} from "./chunk-7RN3L2BX.js";
+import {
+  Menu
+} from "./chunk-A6TQGNDQ.js";
+import {
+  ISOFORM_EXPRESSION
+} from "./chunk-6ITDJ5UR.js";
+
+// termdb/handlers/isoformExpression.ts
+var SearchHandler = class {
+  constructor() {
+    this.currentGene = null;
+  }
+  init(opts) {
+    this.callback = opts.callback;
+    this.app = opts.app;
+    const holder = opts.holder.append("div").style("padding", "10px 0px");
+    this.dom = {
+      errDiv: holder.append("div").style("margin", "5px 0px").style("display", "none")
+    };
+    const geneSearch = addGeneSearchbox({
+      tip: new Menu({ padding: "0px" }),
+      genome: opts.genomeObj,
+      row: holder,
+      searchOnly: "gene",
+      callback: async () => {
+        try {
+          this.dom.errDiv.style("display", "none");
+          if (!geneSearch.geneSymbol) throw new Error("No gene selected");
+          if (geneSearch.geneSymbol === this.currentGene) return;
+          this.currentGene = geneSearch.geneSymbol;
+          if (this.dom.isoformDiv) this.dom.isoformDiv.remove();
+          this.dom.isoformDiv = holder.append("div");
+          await this.showIsoforms(geneSearch.geneSymbol, opts.genomeObj);
+        } catch (e) {
+          this.dom.errDiv.style("display", "block");
+          sayerror(this.dom.errDiv, "Error: " + (e instanceof Error ? e.message : String(e)));
+        }
+      }
+    });
+  }
+  async showIsoforms(gene, genomeObj) {
+    if (!gene) throw new Error("No gene selected");
+    const data = await dofetch3("genelookup", { body: { genome: genomeObj.name, input: gene, deep: 1 } });
+    if (!data.gmlst?.length) throw new Error(`No isoforms found for ${gene}`);
+    const enstCandidates = data.gmlst.filter((gm) => gm.isoform?.startsWith("ENST"));
+    if (enstCandidates.length === 0) throw new Error(`No Ensembl transcript isoforms found for ${gene}`);
+    const { available } = await dofetch3("termdb/isoformAvailability", {
+      body: {
+        genome: genomeObj.name,
+        dslabel: this.app.vocabApi.vocab.dslabel,
+        isoforms: enstCandidates.map((gm) => gm.isoform)
+      }
+    });
+    const availableSet = new Set(available || []);
+    const enstModels = enstCandidates.filter((gm) => availableSet.has(gm.isoform));
+    if (enstModels.length === 0) throw new Error(`No isoforms with data found for ${gene}`);
+    if (gene !== this.currentGene) return;
+    const div = this.dom.isoformDiv;
+    div.append("div").style("margin-bottom", "8px").style("opacity", 0.65).text(`${gene} \u2014 select isoform(s):`);
+    isoformSelect({
+      holder: div,
+      allgm: enstModels,
+      multiSelect: true,
+      submitLabel: "Create Collection",
+      onMultiSelect: (selected) => {
+        if (selected.length === 1) {
+          this.selectIsoform(selected[0].isoform, gene);
+        } else {
+          this.selectCollection(selected, gene);
+        }
+      }
+    });
+  }
+  getUnit() {
+    return this.app.vocabApi.termdbConfig.queries.isoformExpression?.unit || "TPM";
+  }
+  selectIsoform(isoform, gene) {
+    const name = `${isoform} ${this.getUnit()}`;
+    this.callback({ isoform, gene, name, type: ISOFORM_EXPRESSION });
+  }
+  selectCollection(gms, gene) {
+    const unit = this.getUnit();
+    const termlst = gms.map((gm) => ({
+      id: gm.isoform,
+      name: gm.isoform,
+      type: ISOFORM_EXPRESSION,
+      isoform: gm.isoform
+    }));
+    this.callback({
+      type: "termCollection",
+      isCustom: true,
+      memberType: "numeric",
+      name: `${gene} Isoforms (${unit})`,
+      termlst,
+      propsByTermId: {},
+      isleaf: true
+    });
+  }
+};
+function filterIsoforms(gmlst, availableItems) {
+  const itemSet = new Set(availableItems);
+  return gmlst.filter((gm) => gm.isoform?.startsWith("ENST") && (itemSet.size === 0 || itemSet.has(gm.isoform)));
+}
+
+export {
+  SearchHandler,
+  filterIsoforms
+};
+//# sourceMappingURL=chunk-2A2KM5DU.js.map