@sjcrh/proteinpaint-client 2.182.0 → 2.183.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/2dmaf-6ZTETSC5.js +1371 -0
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- package/dist/DEinput-UZEQIU2V.js +297 -0
- package/dist/DifferentialAnalysis-L6BOEYVO.js +238 -0
- package/dist/Disco-6FDT6KRM.js +3235 -0
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- package/dist/NumContEditor-G75O4YZE.js +105 -0
- package/dist/NumContEditor.unit.spec-BFUZRBPL.js +167 -0
- package/dist/NumCustomBinEditor-ILTPHCEF.js +36 -0
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- package/dist/NumRegularBinEditor-7ZJ2MEMY.js +36 -0
- package/dist/NumRegularBinEditor.unit.spec-QGVJET65.js +225 -0
- package/dist/NumSplineEditor-KE4UPODZ.js +190 -0
- package/dist/NumSplineEditor.unit.spec-YQOOZA7S.js +197 -0
- package/dist/NumericDensity-RL42P4QC.js +36 -0
- package/dist/NumericDensity.unit.spec-Y6RMTYC7.js +219 -0
- package/dist/NumericHandler-4QIX324I.js +37 -0
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- package/dist/barchart.events-XRGND6I7.js +45 -0
- package/dist/barchart.integration.spec-VQITP4YH.js +1675 -0
- package/dist/bars.renderer-S7A7I6BQ.js +12 -0
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- package/dist/block.mds.expressionrank-JYZARS7T.js +357 -0
- package/dist/block.mds.geneboxplot-FD2MCIHV.js +826 -0
- package/dist/block.mds.junction-LOHVQBIU.js +1543 -0
- package/dist/block.mds.svcnv-Z7SAYPQL.js +6799 -0
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- package/dist/brainImaging-VSOOMITW.js +421 -0
- package/dist/chat-LW23PIG5.js +148 -0
- package/dist/chunk-2A2KM5DU.js +117 -0
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- /package/dist/{proteomeAbundance-JUYAYO5I.js.map → proteomeAbundance-LTB3QR3G.js.map} +0 -0
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- /package/dist/{regression.inputs.term-TT7PNX6G.js.map → regression.inputs.term-G57GL57T.js.map} +0 -0
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- /package/dist/{regression.results-D4WX6VIV.js.map → regression.results-3YNM6LLQ.js.map} +0 -0
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- /package/dist/{singleCellPlot-E5F62JY6.js.map → singleCellPlot-IWFEG44C.js.map} +0 -0
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- /package/dist/{snp-ACKX4GRX.js.map → snp-UP7WL7WG.js.map} +0 -0
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- /package/dist/{snplocus-7EUOW7J7.js.map → snplocus-WAQK2AZG.js.map} +0 -0
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- /package/dist/{summarizeMutationSurvival-TSNTSOBZ.js.map → summarizeMutationSurvival-22YYXGS5.js.map} +0 -0
- /package/dist/{summary-YRHVS64T.js.map → summary-P3WIKJS7.js.map} +0 -0
- /package/dist/{summary.integration.spec-766YQLQA.js.map → summary.integration.spec-ULGRPICW.js.map} +0 -0
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- /package/dist/{survival-FQXZH2MM.js.map → survival-2ZE3N62A.js.map} +0 -0
- /package/dist/{survival-TVA3ZWVP.js.map → survival-ASCLKIII.js.map} +0 -0
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- /package/dist/{tvs.samplelst-GAP76HRH.js.map → tvs.samplelst-VD2NFFFS.js.map} +0 -0
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- /package/dist/{violin.renderer-QPHLACDC.js.map → violin.renderer-53L4PXUT.js.map} +0 -0
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return state;
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}
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152
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async main() {
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153
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if (this.mayRequireToken()) return;
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154
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this.config = structuredClone(this.state.config);
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155
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this.settings = this.state.config.settings.sampleView;
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156
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this.dom.plotsDiv.selectAll("*").remove();
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157
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this.termsById = this.getTermsById(this.state);
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158
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this.sampleDataByTermId = {};
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159
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const root = this.termsById[root_ID];
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160
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root.terms = await this.requestTermRecursive(root);
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161
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this.orderedVisibleTerms = this.getOrderedVisibleTerms(root);
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162
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if (this.dom.downloadbt)
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163
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this.dom.downloadbt.style("display", this.settings.showDictionary ? "inline-block" : "none");
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164
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if (this.settings.showDictionary) this.renderSampleDictionary();
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165
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this.dom.tableDiv.style("display", this.settings.showDictionary ? "block" : "none");
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166
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await this.renderPlots(this.state, this.state.samples);
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this.showVisiblePlots();
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}
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169
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async setControls(state) {
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170
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const q = state.termdbConfig.queries;
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171
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const hasPlots = q?.singleSampleMutation || q?.singleSampleGenomeQuantification || q?.NIdata || q?.images || q?.DZImages || q?.WSImages;
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if (hasPlots) {
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173
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this.dom.showPlotsDiv.append("input").attr("id", "showDictionary").attr("type", "checkbox").property("checked", true).on("change", (e) => {
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this.app.dispatch({
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type: "plot_edit",
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id: this.id,
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config: { settings: { sampleView: { showDictionary: e.target.checked } } }
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});
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});
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180
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this.dom.showPlotsDiv.append("label").text("Show Dictionary").attr("for", "showDictionary");
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181
|
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}
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182
|
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if (q?.DZImages) {
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183
|
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this.dom.showPlotsDiv.append("input").attr("id", "showDzi").attr("type", "checkbox").property("checked", true).on("change", (e) => {
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this.app.dispatch({
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185
|
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type: "plot_edit",
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186
|
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id: this.id,
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187
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config: { settings: { sampleView: { showDzi: e.target.checked } } }
|
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188
|
-
});
|
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189
|
-
});
|
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190
|
-
this.dom.showPlotsDiv.append("label").attr("for", "showDzi").text("Show DZI images");
|
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191
|
-
}
|
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192
|
-
if (q?.WSImages) {
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193
|
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this.dom.showPlotsDiv.append("input").attr("id", "showWsi").attr("type", "checkbox").property("checked", true).on("change", (e) => {
|
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194
|
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this.app.dispatch({
|
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195
|
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type: "plot_edit",
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196
|
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id: this.id,
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197
|
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config: { settings: { sampleView: { showWsi: e.target.checked } } }
|
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198
|
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});
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199
|
-
});
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200
|
-
this.dom.showPlotsDiv.append("label").attr("for", "showWsi").text("Show WSI images");
|
|
201
|
-
}
|
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202
|
-
if (q?.singleSampleMutation) {
|
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203
|
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this.dom.showPlotsDiv.append("input").attr("type", "checkbox").property("checked", true).attr("id", "showDisco").on("change", (e) => {
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204
|
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this.app.dispatch({
|
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205
|
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type: "plot_edit",
|
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206
|
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id: this.id,
|
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207
|
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config: { settings: { sampleView: { showDisco: e.target.checked } } }
|
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208
|
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});
|
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209
|
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});
|
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210
|
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this.dom.showPlotsDiv.append("label").text("Show Disco").attr("for", "showDisco");
|
|
211
|
-
}
|
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212
|
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if (q?.singleSampleGenomeQuantification) {
|
|
213
|
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for (const ssgqKey in q.singleSampleGenomeQuantification) {
|
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214
|
-
const label = ssgqKey.replace(/([a-z](?=[A-Z]))/g, "$1 ");
|
|
215
|
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this.dom.showPlotsDiv.append("input").attr("type", "checkbox").property("checked", true).attr("id", ssgqKey).on("change", (e) => {
|
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216
|
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this.app.dispatch({
|
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217
|
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type: "plot_edit",
|
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218
|
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id: this.id,
|
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219
|
-
config: { settings: { sampleView: { [ssgqKey]: e.target.checked } } }
|
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220
|
-
});
|
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221
|
-
});
|
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222
|
-
this.dom.showPlotsDiv.append("label").text("Show " + label).attr("for", ssgqKey);
|
|
223
|
-
}
|
|
224
|
-
}
|
|
225
|
-
if (q?.images) {
|
|
226
|
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this.dom.showPlotsDiv.append("input").attr("type", "checkbox").property("checked", true).attr("id", "showImages").on("change", (e) => {
|
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227
|
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this.app.dispatch({
|
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228
|
-
type: "plot_edit",
|
|
229
|
-
id: this.id,
|
|
230
|
-
config: { settings: { sampleView: { showImages: e.target.checked } } }
|
|
231
|
-
});
|
|
232
|
-
});
|
|
233
|
-
this.dom.showPlotsDiv.append("label").text("Show Images").attr("for", "showImages");
|
|
234
|
-
}
|
|
235
|
-
if (q?.NIdata) {
|
|
236
|
-
this.dom.showPlotsDiv.append("input").attr("type", "checkbox").property("checked", true).attr("id", "showBrainImaging").on("change", (e) => {
|
|
237
|
-
this.app.dispatch({
|
|
238
|
-
type: "plot_edit",
|
|
239
|
-
id: this.id,
|
|
240
|
-
config: { settings: { sampleView: { showBrainImaging: e.target.checked } } }
|
|
241
|
-
});
|
|
242
|
-
});
|
|
243
|
-
this.dom.showPlotsDiv.append("label").text("Show brain imaging").attr("for", "showBrainImaging");
|
|
244
|
-
}
|
|
245
|
-
}
|
|
246
|
-
getTermsById(state) {
|
|
247
|
-
if (!(state.activeCohort in this.termsByCohort)) {
|
|
248
|
-
this.termsByCohort[state.activeCohort] = {
|
|
249
|
-
[root_ID]: {
|
|
250
|
-
id: root_ID,
|
|
251
|
-
__tree_isroot: true
|
|
252
|
-
// must not delete this flag
|
|
253
|
-
}
|
|
254
|
-
};
|
|
255
|
-
}
|
|
256
|
-
return this.termsByCohort[state.activeCohort];
|
|
257
|
-
}
|
|
258
|
-
async requestTermRecursive(term, _ancestry = [root_ID]) {
|
|
259
|
-
const data = await this.app.vocabApi.getTermChildren(
|
|
260
|
-
term,
|
|
261
|
-
this.state.toSelectCohort ? this.state.cohortValuelst : null,
|
|
262
|
-
this.state.termfilter.filter
|
|
263
|
-
);
|
|
264
|
-
if (data.error) throw data.error;
|
|
265
|
-
if (!data.lst || data.lst.length == 0) {
|
|
266
|
-
return [];
|
|
267
|
-
}
|
|
268
|
-
const terms = [];
|
|
269
|
-
const parent_id = _ancestry.slice(-1)[0];
|
|
270
|
-
for (const t of data.lst) {
|
|
271
|
-
t.parent_id = parent_id;
|
|
272
|
-
const ancestry = [..._ancestry];
|
|
273
|
-
const copy = structuredClone(t);
|
|
274
|
-
copy.ancestry = ancestry;
|
|
275
|
-
terms.push(copy);
|
|
276
|
-
if (!copy.isleaf && this.config.expandedTermIds.includes(copy.id)) {
|
|
277
|
-
copy.terms = await this.requestTermRecursive(copy, [...ancestry, t.id]);
|
|
278
|
-
if (this.state.samples) await this.fillSampleData(copy.terms);
|
|
279
|
-
} else {
|
|
280
|
-
const t0 = this.termsById[copy.id];
|
|
281
|
-
if (this.state.samples) await this.fillSampleData([copy]);
|
|
282
|
-
if (t0 && t0.terms) {
|
|
283
|
-
copy.terms = t0.terms;
|
|
284
|
-
}
|
|
285
|
-
}
|
|
286
|
-
this.termsById[copy.id] = copy;
|
|
287
|
-
}
|
|
288
|
-
return terms;
|
|
289
|
-
}
|
|
290
|
-
getOrderedVisibleTerms(root) {
|
|
291
|
-
const visibleTerms = Object.values(this.termsById).filter(this.isVisibleTermId.bind(this));
|
|
292
|
-
const orderedVisibleTerms = [];
|
|
293
|
-
this.sortVisibleTerms(this.termsById[root_ID], visibleTerms, orderedVisibleTerms);
|
|
294
|
-
return orderedVisibleTerms;
|
|
295
|
-
}
|
|
296
|
-
isVisibleTermId(term) {
|
|
297
|
-
if (term.parent_id == root_ID) return true;
|
|
298
|
-
if (!term.ancestry) return false;
|
|
299
|
-
for (const pid of term.ancestry) {
|
|
300
|
-
if (pid === root_ID) continue;
|
|
301
|
-
if (!this.config.expandedTermIds.includes(pid)) return false;
|
|
302
|
-
}
|
|
303
|
-
return true;
|
|
304
|
-
}
|
|
305
|
-
sortVisibleTerms(currParent, remainingTerms, currOrder = []) {
|
|
306
|
-
const unorderedTerms = [];
|
|
307
|
-
const orderedTerms = [];
|
|
308
|
-
for (const term of remainingTerms) {
|
|
309
|
-
if (term.parent_id == currParent.id) {
|
|
310
|
-
orderedTerms.push(term);
|
|
311
|
-
} else unorderedTerms.push(term);
|
|
312
|
-
}
|
|
313
|
-
remainingTerms.splice(0, remainingTerms.length, ...unorderedTerms);
|
|
314
|
-
if (remainingTerms.length) {
|
|
315
|
-
for (const term of orderedTerms) {
|
|
316
|
-
currOrder.push(term);
|
|
317
|
-
if (!term.isleaf && remainingTerms.length) {
|
|
318
|
-
this.sortVisibleTerms(term, remainingTerms, currOrder);
|
|
319
|
-
}
|
|
320
|
-
}
|
|
321
|
-
} else {
|
|
322
|
-
currOrder.push(...orderedTerms);
|
|
323
|
-
}
|
|
324
|
-
}
|
|
325
|
-
async fillSampleData(terms) {
|
|
326
|
-
const term_ids = [];
|
|
327
|
-
for (const term of terms) term_ids.push(term.id);
|
|
328
|
-
for (const sample of this.state.samples) {
|
|
329
|
-
const data = await this.app.vocabApi.getSingleSampleData({
|
|
330
|
-
sampleId: sample.sampleId,
|
|
331
|
-
term_ids,
|
|
332
|
-
filter: this.state.termfilter.filter
|
|
333
|
-
});
|
|
334
|
-
if ("error" in data) throw data.error;
|
|
335
|
-
if (!this.sampleDataByTermId[sample.sampleId]) this.sampleDataByTermId[sample.sampleId] = {};
|
|
336
|
-
for (const id in data) this.sampleDataByTermId[sample.sampleId][id] = data[id];
|
|
337
|
-
}
|
|
338
|
-
}
|
|
339
|
-
async downloadData() {
|
|
340
|
-
this.dom.messageDiv.style("display", "block");
|
|
341
|
-
this.dom.downloadbt.style("display", "none");
|
|
342
|
-
const filename = `samples.tsv`;
|
|
343
|
-
const sampleData = {};
|
|
344
|
-
let lines = "Sample";
|
|
345
|
-
for (const sample of this.state.samples) {
|
|
346
|
-
sampleData[sample.sampleId] = await this.app.vocabApi.getSingleSampleData({
|
|
347
|
-
sampleId: sample.sampleId,
|
|
348
|
-
/** term_ids is required for getSingleSampleData but not
|
|
349
|
-
* available in this instance. Pass empty array.*/
|
|
350
|
-
term_ids: [],
|
|
351
|
-
filter: this.state.termfilter.filter || []
|
|
352
|
-
});
|
|
353
|
-
lines += ` ${sample.sampleName}`;
|
|
354
|
-
}
|
|
355
|
-
lines += "\n";
|
|
356
|
-
const sampleId = this.state.samples[0].sampleId;
|
|
357
|
-
for (const termId in sampleData[sampleId]) {
|
|
358
|
-
const term = sampleData[sampleId][termId].term;
|
|
359
|
-
lines += `${term.name}`;
|
|
360
|
-
for (const sampleId2 in sampleData) {
|
|
361
|
-
const data = sampleData[sampleId2];
|
|
362
|
-
let value = getTermValue(term, data);
|
|
363
|
-
if (value == null) value = "Missing";
|
|
364
|
-
lines += ` ${value}`;
|
|
365
|
-
}
|
|
366
|
-
lines += "\n";
|
|
367
|
-
}
|
|
368
|
-
const dataStr = "data:text/tsv;charset=utf-8," + encodeURIComponent(lines);
|
|
369
|
-
const link = document.createElement("a");
|
|
370
|
-
link.setAttribute("href", dataStr);
|
|
371
|
-
link.setAttribute("download", filename);
|
|
372
|
-
document.body.appendChild(link);
|
|
373
|
-
link.click();
|
|
374
|
-
link.remove();
|
|
375
|
-
this.dom.messageDiv.style("display", "none");
|
|
376
|
-
this.dom.downloadbt.style("display", "inline-block");
|
|
377
|
-
}
|
|
378
|
-
mayRequireToken() {
|
|
379
|
-
if (this.state.hasVerifiedToken) {
|
|
380
|
-
this.dom.holder.style("display", "block");
|
|
381
|
-
return false;
|
|
382
|
-
} else {
|
|
383
|
-
const e = this.state.tokenVerificationPayload;
|
|
384
|
-
const missingAccess = e?.error == "Missing access" && this.state.termdbConfig.dataDownloadCatch?.missingAccess;
|
|
385
|
-
const message = missingAccess?.message?.replace("MISSING-ACCESS-LINK", missingAccess?.links[e?.linkKey]);
|
|
386
|
-
const helpLink = this.state.termdbConfig.dataDownloadCatch?.helpLink;
|
|
387
|
-
this.dom.holder.style("color", "#e44").style("padding", "10px").html(
|
|
388
|
-
message || (this.state.tokenVerificationMessage || "Requires sign-in") + (helpLink ? ` <a href='${helpLink}' target=_blank>Tutorial</a>` : "")
|
|
389
|
-
);
|
|
390
|
-
return true;
|
|
391
|
-
}
|
|
392
|
-
}
|
|
393
|
-
showVisiblePlots() {
|
|
394
|
-
this.visiblePlots = false;
|
|
395
|
-
this.showPlotsFromCategory(this.discoPlots, "showDisco");
|
|
396
|
-
for (const ssgqKey in this.state.singleSampleGenomeQuantification)
|
|
397
|
-
this.showPlotsFromCategory(this.singleSamplePlots[ssgqKey], ssgqKey);
|
|
398
|
-
this.showPlotsFromCategory(this.brainPlots, "showBrain");
|
|
399
|
-
this.showPlotsFromCategory(this.imagePlots, "showImages");
|
|
400
|
-
this.showPlotsFromCategory(this.dziPlots, "showDzi");
|
|
401
|
-
this.showPlotsFromCategory(this.wsiPlots, "showWsi");
|
|
402
|
-
if (this.state.samples.length == 1 && this.visiblePlots)
|
|
403
|
-
this.dom.tableDiv.style("max-width", "48vw").style("max-height", "40vw").attr("class", "sjpp_show_scrollbar");
|
|
404
|
-
else this.dom.tableDiv.style("max-width", "").style("max-height", "").attr("class", "");
|
|
405
|
-
}
|
|
406
|
-
showPlotsFromCategory(plots, key) {
|
|
407
|
-
for (const div of plots) {
|
|
408
|
-
const visibleSample = this.state.samples.find((s) => s.sampleName == div.sample.sampleName);
|
|
409
|
-
const visiblePlot = this.settings[key] && visibleSample;
|
|
410
|
-
if (visiblePlot) this.visiblePlots = true;
|
|
411
|
-
div.cellDiv.style("display", visiblePlot ? "table-cell" : "none");
|
|
412
|
-
}
|
|
413
|
-
}
|
|
414
|
-
async renderPlots(state, samples) {
|
|
415
|
-
const plotsDiv = this.dom.plotsDiv;
|
|
416
|
-
this.discoPlots = [];
|
|
417
|
-
this.singleSamplePlots = {};
|
|
418
|
-
this.brainPlots = [];
|
|
419
|
-
this.imagePlots = [];
|
|
420
|
-
this.dziPlots = [];
|
|
421
|
-
this.wsiPlots = [];
|
|
422
|
-
const q = state.termdbConfig.queries;
|
|
423
|
-
if (state.termdbConfig.queries?.DZImages) {
|
|
424
|
-
let div = plotsDiv.append("div");
|
|
425
|
-
if (state.samples.length == 1) div.style("display", "inline-block").style("width", "50vw");
|
|
426
|
-
for (const sample of samples) {
|
|
427
|
-
const data = await dofetch3("sampledzimages", {
|
|
428
|
-
body: {
|
|
429
|
-
genome: this.app.opts.genome.name,
|
|
430
|
-
dslabel: state.vocab.dslabel,
|
|
431
|
-
sample_id: sample.sampleName
|
|
432
|
-
}
|
|
433
|
-
});
|
|
434
|
-
if (data.sampleDZImages?.length > 0) {
|
|
435
|
-
const cellDiv = div.append("div").style("display", "inline-block");
|
|
436
|
-
this.dziPlots.push({ sample, cellDiv });
|
|
437
|
-
const dziviewer = await import("./plot.dzi-PC34YI6Y.js");
|
|
438
|
-
dziviewer.default(state.vocab.dslabel, cellDiv, this.app.opts.genome, sample.sampleName, data.sampleDZImages);
|
|
439
|
-
}
|
|
440
|
-
}
|
|
441
|
-
}
|
|
442
|
-
if (state.termdbConfig.queries?.WSImages) {
|
|
443
|
-
let div = plotsDiv.append("div");
|
|
444
|
-
if (state.samples.length == 1) div.style("display", "inline-block").style("width", "50vw");
|
|
445
|
-
for (const sample of samples) {
|
|
446
|
-
const cellDiv = div.append("div").style("display", "inline-block");
|
|
447
|
-
this.wsiPlots.push({ sample, cellDiv });
|
|
448
|
-
const wsiViewer = await import("./plot.wsi-YYXFAZWY.js");
|
|
449
|
-
wsiViewer.default(state.vocab.dslabel, cellDiv, this.app.opts.genome, sample.sampleName);
|
|
450
|
-
}
|
|
451
|
-
}
|
|
452
|
-
if (state.termdbConfig?.queries?.singleSampleMutation) {
|
|
453
|
-
let div = plotsDiv.append("div");
|
|
454
|
-
if (state.samples.length == 1) div.style("display", "inline-block").style("width", "50vw");
|
|
455
|
-
let someFound = false;
|
|
456
|
-
for (const sample of samples) {
|
|
457
|
-
const cellDiv = div.append("div").style("display", "inline-block");
|
|
458
|
-
this.discoPlots.push({ sample, cellDiv });
|
|
459
|
-
const header = cellDiv.insert("div");
|
|
460
|
-
const discoPlotImport = await import("./plot.disco-2KTKB3XX.js");
|
|
461
|
-
const found = await discoPlotImport.default(
|
|
462
|
-
state.termdbConfig,
|
|
463
|
-
state.vocab.dslabel,
|
|
464
|
-
{ sample_id: sample.sampleName },
|
|
465
|
-
cellDiv,
|
|
466
|
-
this.app.opts.genome,
|
|
467
|
-
{},
|
|
468
|
-
//overrides
|
|
469
|
-
false
|
|
470
|
-
//showError
|
|
471
|
-
);
|
|
472
|
-
if (found) {
|
|
473
|
-
if (state.samples.length > 1)
|
|
474
|
-
header.style("font-weight", "bold").style("padding-left", "20px").text(sample.sampleName);
|
|
475
|
-
someFound = true;
|
|
476
|
-
}
|
|
477
|
-
}
|
|
478
|
-
this.dom.showPlotsDiv.select("input[id=showDisco").style("display", someFound ? "inline-block" : "none");
|
|
479
|
-
this.dom.showPlotsDiv.select("label[for=showDisco").style("display", someFound ? "inline-block" : "none");
|
|
480
|
-
}
|
|
481
|
-
if (state.termdbConfig.queries?.singleSampleGenomeQuantification) {
|
|
482
|
-
for (const k in state.termdbConfig.queries.singleSampleGenomeQuantification) {
|
|
483
|
-
let someFound = false;
|
|
484
|
-
this.singleSamplePlots[k] = [];
|
|
485
|
-
let div = plotsDiv.append("div");
|
|
486
|
-
if (state.samples.length == 1) div.style("display", "inline-block").style("width", "50vw");
|
|
487
|
-
for (const sample of samples) {
|
|
488
|
-
const label = k.match(/[A-Z][a-z]+|[0-9]+/g).join(" ");
|
|
489
|
-
const plotDiv = div.insert("div").style("display", "table-cell").style("padding", "20px");
|
|
490
|
-
this.singleSamplePlots[k].push({ sample, cellDiv: plotDiv });
|
|
491
|
-
if (state.samples.length > 1)
|
|
492
|
-
plotDiv.insert("div").style("font-weight", "bold").text(`${sample.sampleName} ${label}`);
|
|
493
|
-
const ssgqImport = await import("./plot.ssgq-Z4UNJKWO.js");
|
|
494
|
-
const found = await ssgqImport.plotSingleSampleGenomeQuantification(
|
|
495
|
-
state.termdbConfig,
|
|
496
|
-
state.vocab.dslabel,
|
|
497
|
-
k,
|
|
498
|
-
{ sample_id: sample.sampleName },
|
|
499
|
-
plotDiv.insert("div"),
|
|
500
|
-
this.app.opts.genome,
|
|
501
|
-
null,
|
|
502
|
-
//geneName
|
|
503
|
-
false
|
|
504
|
-
//showError
|
|
505
|
-
);
|
|
506
|
-
if (found) someFound = true;
|
|
507
|
-
}
|
|
508
|
-
this.dom.showPlotsDiv.select(`input[id=${k}`).style("display", someFound ? "inline-block" : "none");
|
|
509
|
-
this.dom.showPlotsDiv.select(`label[for=${k}`).style("display", someFound ? "inline-block" : "none");
|
|
510
|
-
}
|
|
511
|
-
}
|
|
512
|
-
if (state.termdbConfig.queries?.NIdata) {
|
|
513
|
-
let div = plotsDiv.append("div");
|
|
514
|
-
if (state.samples.length == 1) div.style("display", "inline-block");
|
|
515
|
-
for (const k in state.termdbConfig.queries?.NIdata) {
|
|
516
|
-
let div2 = plotsDiv.append("div");
|
|
517
|
-
if (state.samples.length == 1) div2.style("display", "inline-block").style("width", "50vw");
|
|
518
|
-
for (const sample of samples) {
|
|
519
|
-
const plotDiv = div2.insert("div").style("display", "inline-block");
|
|
520
|
-
this.brainPlots.push({ sample, cellDiv: plotDiv });
|
|
521
|
-
if (state.samples.length > 1)
|
|
522
|
-
plotDiv.insert("div").style("font-weight", "bold").style("padding-left", "20px").text(sample.sampleName);
|
|
523
|
-
const brainImagingImport = await import("./plot.brainImaging-ZJPFWX2W.js");
|
|
524
|
-
brainImagingImport.default(
|
|
525
|
-
state.termdbConfig,
|
|
526
|
-
state.vocab.dslabel,
|
|
527
|
-
k,
|
|
528
|
-
{ sample_id: sample.sampleName },
|
|
529
|
-
plotDiv,
|
|
530
|
-
this.app.opts.genome
|
|
531
|
-
);
|
|
532
|
-
}
|
|
533
|
-
}
|
|
534
|
-
}
|
|
535
|
-
if (state.termdbConfig?.queries?.images) {
|
|
536
|
-
let div = plotsDiv.append("div");
|
|
537
|
-
if (state.samples.length == 1) div.style("display", "inline-block").style("width", "50vw");
|
|
538
|
-
for (const sample of samples) {
|
|
539
|
-
const cellDiv = div.append("div").style("display", "inline-block");
|
|
540
|
-
this.imagePlots.push({ sample, cellDiv });
|
|
541
|
-
if (state.samples.length > 1)
|
|
542
|
-
cellDiv.insert("div").style("font-weight", "bold").style("padding-left", "20px").text(sample.sampleName);
|
|
543
|
-
const imagePlotImport = await import("./imagePlot-V4WLAPV6.js");
|
|
544
|
-
imagePlotImport.renderImagePlot(state, cellDiv, sample);
|
|
545
|
-
}
|
|
546
|
-
}
|
|
547
|
-
}
|
|
548
|
-
};
|
|
549
|
-
function getTermValue(term, data) {
|
|
550
|
-
let value = data[term.id]?.value;
|
|
551
|
-
if (value == null || value == void 0 || value == "undefined") return null;
|
|
552
|
-
if (term.type == "date") return getDateStrFromNumber(value);
|
|
553
|
-
if (isNumericTerm(term)) {
|
|
554
|
-
value = term.values?.[value]?.label || term.values?.[value]?.key || value;
|
|
555
|
-
if (isNaN(value)) return value;
|
|
556
|
-
return value % 1 == 0 ? value.toString() : value.toFixed(2).toString();
|
|
557
|
-
}
|
|
558
|
-
if (term.type == "categorical") return term.values[value]?.label || term.values[value]?.key;
|
|
559
|
-
if (term.type == "condition") {
|
|
560
|
-
const values = value.toString().split(" ");
|
|
561
|
-
let [years, status] = values;
|
|
562
|
-
status = term.values[status].label || term.values[status].key;
|
|
563
|
-
return `Max grade: ${status}, Time to event: ${Number(years).toFixed(1)} years`;
|
|
564
|
-
}
|
|
565
|
-
if (term.type == "survival") {
|
|
566
|
-
const values = value.split(" ");
|
|
567
|
-
let [years, status] = values;
|
|
568
|
-
status = term.values?.[status]?.label || term.values?.[status]?.key || status;
|
|
569
|
-
return `${status} after ${Number(years).toFixed(1)} years`;
|
|
570
|
-
}
|
|
571
|
-
return null;
|
|
572
|
-
}
|
|
573
|
-
var sampleViewInit = getCompInit(SampleView);
|
|
574
|
-
var componentInit = sampleViewInit;
|
|
575
|
-
function setRenderers(self) {
|
|
576
|
-
self.renderSampleDictionary = function() {
|
|
577
|
-
this.dom.tableDiv = this.dom.plotsDiv.append("div").style("display", "inline-block").style("padding", "20px");
|
|
578
|
-
const table = this.dom.tableDiv.append("table").style("border-collapse", "collapse");
|
|
579
|
-
const thead = table.append("thead");
|
|
580
|
-
const theadrow = thead.append("tr");
|
|
581
|
-
const tbody = table.append("tbody");
|
|
582
|
-
const visibleSamples = [];
|
|
583
|
-
for (const sample of self.state.samples) visibleSamples.push(self.sampleDataByTermId[sample.sampleId]);
|
|
584
|
-
self.renderTHead(["", ...self.state.samples.map((s) => s.sampleName)], theadrow);
|
|
585
|
-
const tBodyData = self.orderedVisibleTerms.map((term, trIndex) => [
|
|
586
|
-
{ term },
|
|
587
|
-
// first column, no sample data
|
|
588
|
-
// create data to bind for each sample column
|
|
589
|
-
...visibleSamples.map((sample) => ({ term, sample }))
|
|
590
|
-
]);
|
|
591
|
-
self.renderTBody(tBodyData, tbody);
|
|
592
|
-
};
|
|
593
|
-
self.renderTHead = function(data, theadrow) {
|
|
594
|
-
const trs = theadrow.selectAll("th").data(data);
|
|
595
|
-
trs.exit().remove();
|
|
596
|
-
trs.html(self.getThHtml);
|
|
597
|
-
trs.enter().append("th").style("padding", "5px 10px").style("text-align", "end").html(self.getThHtml);
|
|
598
|
-
};
|
|
599
|
-
self.getThHtml = (d) => d;
|
|
600
|
-
self.renderTBody = function(data, tbody) {
|
|
601
|
-
const trs = tbody.selectAll("tr").data(data);
|
|
602
|
-
trs.exit().remove();
|
|
603
|
-
trs.each(self.renderTr);
|
|
604
|
-
trs.enter().append("tr").each(self.renderTr);
|
|
605
|
-
};
|
|
606
|
-
self.renderTr = function(trData, trIndex) {
|
|
607
|
-
const tds = select_default(this).selectAll("td").data(trData, (d) => d);
|
|
608
|
-
tds.exit().remove();
|
|
609
|
-
tds.each(self.renderTd);
|
|
610
|
-
tds.enter().append("td").style("border-bottom", "solid 1px rgb(245,245,245)").style("text-align", (d, i) => i === 0 ? "left" : "center").style("padding", "2px 10px").each(self.renderTd);
|
|
611
|
-
};
|
|
612
|
-
self.renderTd = function(d, i) {
|
|
613
|
-
if (!d.sample) {
|
|
614
|
-
self.renderTerm(select_default(this));
|
|
615
|
-
return;
|
|
616
|
-
}
|
|
617
|
-
const data = d.sample;
|
|
618
|
-
const term = d.term;
|
|
619
|
-
const isNumeric = isNumericTerm(term);
|
|
620
|
-
const value = getTermValue(d.term, d.sample);
|
|
621
|
-
const td = select_default(this).datum(d).style("text-align", "end").style("padding", "5px 10px").html(d.sample[d.term.id]?.label || value);
|
|
622
|
-
if (isNumeric)
|
|
623
|
-
td.append("button").style("margin-left", "5px").text("Plot").on("click", (e) => {
|
|
624
|
-
const tw = { id: term.id, q: { mode: "continuous" } };
|
|
625
|
-
self.app.dispatch({ type: "plot_create", config: { chartType: "violin", term: tw, value } });
|
|
626
|
-
});
|
|
627
|
-
};
|
|
628
|
-
self.renderTerm = function(td) {
|
|
629
|
-
const d = td.datum();
|
|
630
|
-
if (!td.select("span").size()) {
|
|
631
|
-
const span2 = td.append("span");
|
|
632
|
-
span2.append("button").style("border-width", 0).style("border-radius", "5px").style("width", "28px").style("height", "28px").style("cursor", "pointer");
|
|
633
|
-
span2.append("span").style("margin-left", `3px`).style("cursor", "pointer");
|
|
634
|
-
td.on("click", self.toggleTerm);
|
|
635
|
-
}
|
|
636
|
-
const leftIndent = (d.term.ancestry.length - 1) * 24;
|
|
637
|
-
const span = td.select(":scope>span").style("margin-left", `${leftIndent}px`);
|
|
638
|
-
const btn = span.select("button").style("display", d.term.isleaf ? "none" : "").html(self.config.expandedTermIds.includes(d.term.id) ? "-" : "+");
|
|
639
|
-
span.select("span").html(d.term.name);
|
|
640
|
-
return;
|
|
641
|
-
};
|
|
642
|
-
}
|
|
643
|
-
function setInteractivity(self) {
|
|
644
|
-
self.toggleTerm = function() {
|
|
645
|
-
const d = select_default(this).datum();
|
|
646
|
-
if (d.term.isleaf) return;
|
|
647
|
-
const expandedTermIds = self.config.expandedTermIds.slice();
|
|
648
|
-
const i = expandedTermIds.indexOf(d.term.id);
|
|
649
|
-
if (i == -1) expandedTermIds.push(d.term.id);
|
|
650
|
-
else expandedTermIds.splice(i, 1);
|
|
651
|
-
self.app.dispatch({
|
|
652
|
-
type: "plot_edit",
|
|
653
|
-
id: self.id,
|
|
654
|
-
config: { expandedTermIds }
|
|
655
|
-
});
|
|
656
|
-
};
|
|
657
|
-
}
|
|
658
|
-
async function getPlotConfig(opts, app) {
|
|
659
|
-
const q = app.getState()?.termdbConfig?.queries;
|
|
660
|
-
const settings = {
|
|
661
|
-
sampleView: {
|
|
662
|
-
showDictionary: true,
|
|
663
|
-
showDisco: true,
|
|
664
|
-
showBrain: true,
|
|
665
|
-
showImages: true,
|
|
666
|
-
showDzi: true,
|
|
667
|
-
showWsi: true
|
|
668
|
-
}
|
|
669
|
-
};
|
|
670
|
-
if (q)
|
|
671
|
-
for (const ssgqKey in q.singleSampleGenomeQuantification) settings.sampleView[ssgqKey] = true;
|
|
672
|
-
const config = { activeCohort: 0, sample: null, expandedTermIds: [root_ID], settings, hidePlotFilter: true };
|
|
673
|
-
return copyMerge(config, opts);
|
|
674
|
-
}
|
|
675
|
-
function searchSampleInput(holder, samplesData, hasSampleAncestry, callback, keyUpCallback) {
|
|
676
|
-
const limit = 100;
|
|
677
|
-
const allSamples = [];
|
|
678
|
-
for (const sample in samplesData) {
|
|
679
|
-
const sample_type = samplesData[sample].sample_type;
|
|
680
|
-
if (sample_type == ROOT_SAMPLE_TYPE || sample_type == null || !hasSampleAncestry && sample_type == DEFAULT_SAMPLE_TYPE)
|
|
681
|
-
allSamples.push(sample);
|
|
682
|
-
}
|
|
683
|
-
const isBigDataset = allSamples.length > 1e4;
|
|
684
|
-
if (allSamples.length == 0)
|
|
685
|
-
return;
|
|
686
|
-
const { childrenByParent, rootFor } = buildHierarchy(samplesData);
|
|
687
|
-
const sampleName = allSamples[0];
|
|
688
|
-
const input = holder.append("input").attr("list", "sampleDatalist").property("autocomplete", "off").attr("placeholder", sampleName).style("width", "250px");
|
|
689
|
-
holder.style("opacity", "0.8");
|
|
690
|
-
const datalist = holder.append("datalist").attr("id", "sampleDatalist");
|
|
691
|
-
addOptions(allSamples);
|
|
692
|
-
input.on("keyup", (e) => {
|
|
693
|
-
datalist.selectAll("*").remove();
|
|
694
|
-
const str = input.node().value.toLowerCase();
|
|
695
|
-
if (keyUpCallback) keyUpCallback(str);
|
|
696
|
-
const options = [];
|
|
697
|
-
for (const sample of allSamples) {
|
|
698
|
-
if (sample.toLowerCase().startsWith(str)) options.push(sample);
|
|
699
|
-
if (options.length == limit && allSamples.length > 1e4) break;
|
|
700
|
-
}
|
|
701
|
-
for (const sample of allSamples) {
|
|
702
|
-
if (sample.toLowerCase().includes(str) && !options.includes(sample)) options.push(sample);
|
|
703
|
-
if (options.length == limit && allSamples.length > 1e4) break;
|
|
704
|
-
}
|
|
705
|
-
if (options.length > 1 || options.length == 1 && input.node().value != options[0]) addOptions(options, this);
|
|
706
|
-
});
|
|
707
|
-
input.on("change", (e) => {
|
|
708
|
-
const sampleName2 = input.node().value;
|
|
709
|
-
callback(sampleName2);
|
|
710
|
-
});
|
|
711
|
-
function addOptions(options) {
|
|
712
|
-
datalist.selectAll("option").data(options.filter((s, i) => i < limit)).enter().append("option").attr("value", (d) => d).attr(
|
|
713
|
-
"label",
|
|
714
|
-
(d, i) => getLabel(d, childrenByParent, rootFor) + (i + 1 == limit ? isBigDataset ? ` Showing first ${i + 1} hits` : ` Showing ${i + 1} of ${options.length} hits` : i + 1 === options.length && i > 0 ? ` (Found ${options.length} hits)` : "")
|
|
715
|
-
);
|
|
716
|
-
}
|
|
717
|
-
function getLabel(sampleName2, childrenByParent2, rootFor2) {
|
|
718
|
-
const rootName = rootFor2.get(sampleName2) || sampleName2;
|
|
719
|
-
if (!childrenByParent2.has(rootName)) return sampleName2;
|
|
720
|
-
const rootChildren = childrenByParent2.get(rootName) || [];
|
|
721
|
-
if (rootChildren.length === 0) return sampleName2;
|
|
722
|
-
const parts = [];
|
|
723
|
-
for (const child of rootChildren) {
|
|
724
|
-
let chain = [child];
|
|
725
|
-
let cur = child;
|
|
726
|
-
while (true) {
|
|
727
|
-
const kids = childrenByParent2.get(cur) || [];
|
|
728
|
-
if (kids.length === 0) break;
|
|
729
|
-
chain.push(kids[0]);
|
|
730
|
-
cur = kids[0];
|
|
731
|
-
}
|
|
732
|
-
parts.push(chain.length > 1 ? chain.join(" > ") : child);
|
|
733
|
-
}
|
|
734
|
-
return parts.join(", ");
|
|
735
|
-
}
|
|
736
|
-
return sampleName;
|
|
737
|
-
}
|
|
738
|
-
function buildHierarchy(samplesData) {
|
|
739
|
-
let childrenByParent = /* @__PURE__ */ new Map();
|
|
740
|
-
let rootFor = /* @__PURE__ */ new Map();
|
|
741
|
-
for (const s of Object.values(samplesData)) {
|
|
742
|
-
const childName = s.name;
|
|
743
|
-
const parentName = s.ancestor_name;
|
|
744
|
-
if (parentName) {
|
|
745
|
-
if (!childrenByParent.has(parentName)) {
|
|
746
|
-
childrenByParent.set(parentName, []);
|
|
747
|
-
}
|
|
748
|
-
childrenByParent.get(parentName).push(childName);
|
|
749
|
-
}
|
|
750
|
-
let root = childName;
|
|
751
|
-
let curr = s;
|
|
752
|
-
while (curr?.ancestor_name) {
|
|
753
|
-
root = curr.ancestor_name;
|
|
754
|
-
curr = samplesData[root];
|
|
755
|
-
}
|
|
756
|
-
rootFor.set(childName, root);
|
|
757
|
-
}
|
|
758
|
-
for (const list of childrenByParent.values()) {
|
|
759
|
-
list.sort((a, b) => {
|
|
760
|
-
const na = Number(a);
|
|
761
|
-
const nb = Number(b);
|
|
762
|
-
return !isNaN(na) && !isNaN(nb) ? na - nb : a.localeCompare(b);
|
|
763
|
-
});
|
|
764
|
-
}
|
|
765
|
-
return { childrenByParent, rootFor };
|
|
766
|
-
}
|
|
767
|
-
function getSamplesRelated(samplesData, sampleName, childrenByParent = null, rootFor) {
|
|
768
|
-
if (!samplesData[sampleName]) return [];
|
|
769
|
-
let rootName;
|
|
770
|
-
if (rootFor && childrenByParent) {
|
|
771
|
-
rootName = rootFor.get(sampleName);
|
|
772
|
-
} else {
|
|
773
|
-
rootName = sampleName;
|
|
774
|
-
let current = samplesData[sampleName];
|
|
775
|
-
while (current?.ancestor_name) {
|
|
776
|
-
rootName = current.ancestor_name;
|
|
777
|
-
current = samplesData[rootName];
|
|
778
|
-
}
|
|
779
|
-
}
|
|
780
|
-
const root = samplesData[rootName];
|
|
781
|
-
if (!root) return [];
|
|
782
|
-
let kidsMap = childrenByParent;
|
|
783
|
-
if (!kidsMap) {
|
|
784
|
-
kidsMap = /* @__PURE__ */ new Map();
|
|
785
|
-
for (const s of Object.values(samplesData)) {
|
|
786
|
-
if (s.ancestor_name) {
|
|
787
|
-
if (!kidsMap.has(s.ancestor_name)) kidsMap.set(s.ancestor_name, []);
|
|
788
|
-
kidsMap.get(s.ancestor_name).push(s);
|
|
789
|
-
}
|
|
790
|
-
}
|
|
791
|
-
for (const list of kidsMap.values()) {
|
|
792
|
-
list.sort((a, b) => {
|
|
793
|
-
const na = Number(a.name);
|
|
794
|
-
const nb = Number(b.name);
|
|
795
|
-
if (!isNaN(na) && !isNaN(nb)) return na - nb;
|
|
796
|
-
return a.name.localeCompare(b.name);
|
|
797
|
-
});
|
|
798
|
-
}
|
|
799
|
-
}
|
|
800
|
-
const samples = [];
|
|
801
|
-
const hasChildren = (kidsMap.get(rootName) || []).length > 0;
|
|
802
|
-
if (root.sample_type !== ROOT_SAMPLE_TYPE || !hasChildren) {
|
|
803
|
-
samples.push({ sampleId: root.id, sampleName: root.name });
|
|
804
|
-
}
|
|
805
|
-
function traverse(parentName) {
|
|
806
|
-
const kids = kidsMap.get(parentName) || [];
|
|
807
|
-
for (const kid of kids) {
|
|
808
|
-
samples.push({ sampleId: kid.id, sampleName: kid.name });
|
|
809
|
-
traverse(kid.name);
|
|
810
|
-
}
|
|
811
|
-
}
|
|
812
|
-
traverse(rootName);
|
|
813
|
-
return samples;
|
|
814
|
-
}
|
|
815
|
-
|
|
816
|
-
export {
|
|
817
|
-
getTermValue,
|
|
818
|
-
sampleViewInit,
|
|
819
|
-
componentInit,
|
|
820
|
-
getPlotConfig,
|
|
821
|
-
searchSampleInput,
|
|
822
|
-
getSamplesRelated
|
|
823
|
-
};
|
|
824
|
-
//# sourceMappingURL=chunk-YOTWMCT5.js.map
|