@pikaa-ai/pikaa 0.3.22 → 0.3.24

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  5. package/dist/cli.js +448 -181
  6. package/dist/index.js +22 -2
  7. package/package.json +1 -2
  8. package/skills/adaptyv/SKILL.md +0 -240
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- ---
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- name: generate-image
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- description: Generate or edit images with AI models through the OpenRouter Image API (Gemini, Seedream, Recraft, GPT-Image, Riverflow). Use for photos, illustrations, artwork, concept art, visual assets, logos, and image editing or compositing from reference images. For flowcharts, circuits, pathways, and other technical diagrams, use the scientific-schematics skill instead.
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- license: MIT
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- compatibility: Requires Python 3.9+ and network access to openrouter.ai. The bundled script uses only the standard library. Image generation requires the OPENROUTER_API_KEY credential and bills per request; listing models, inspecting a model, and --dry-run do not. Targets the OpenRouter Image API (POST /api/v1/images) as verified on 2026-07-31.
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- allowed-tools: Read Write Edit Bash
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- metadata:
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- version: "3.0"
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- skill-author: K-Dense Inc.
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- last-reviewed: "2026-07-31"
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- openclaw:
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- primaryEnv: OPENROUTER_API_KEY
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- envVars:
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- - name: OPENROUTER_API_KEY
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- required: true
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- description: OpenRouter API key used for image generation.
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- ---
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-
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- # Generate Image
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-
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- Generate and edit images through OpenRouter's Image API, which reaches Gemini, Seedream, Recraft,
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- GPT-Image, Riverflow, and roughly thirty other models behind one request shape.
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-
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- ## When to use
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-
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- **Use this skill for:** photos and photorealistic images, illustrations and artwork, concept art,
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- presentation and poster visuals, logos and vector marks, image editing, and compositing from
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- reference images.
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-
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- **Use `scientific-schematics` instead for:** flowcharts, circuit diagrams, biological pathways,
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- system architecture diagrams, CONSORT diagrams, and other technical schematics.
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-
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- ## API key
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-
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- Generation requires an OpenRouter key. The script resolves it in this order:
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-
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- 1. `--api-key`
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- 2. the `OPENROUTER_API_KEY` environment variable
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- 3. `OPENROUTER_API_KEY=` in a `.env` file, searching the working directory upward, then the
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- script's own directory
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-
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- If none is present the script exits with setup instructions. Keys: https://openrouter.ai/keys
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-
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- `--list-models`, `--model-info`, and `--dry-run` need no key.
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-
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- ## Quick start
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-
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- ```bash
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- # Generate
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- python scripts/generate_image.py "A beautiful sunset over mountains"
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-
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- # Edit an existing image
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- python scripts/generate_image.py "Make the sky purple" -i photo.jpg -o edited.png
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- ```
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-
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- Paths are relative to this skill's directory. Output defaults to `generated_image.<ext>`, where the
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- extension follows the media type the model returned. The per-request cost is printed after the run.
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-
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- **Then look at the image.** Read the file back and check it before using it anywhere: composition,
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- aspect ratio, and any text are all things models get wrong silently.
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-
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- ## Choosing a model
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-
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- Default: `google/gemini-3.1-flash-image`.
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-
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- | Need | Model |
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- | --- | --- |
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- | General quality, prompt adherence | `google/gemini-3.1-flash-image` |
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- | Highest Gemini tier | `google/gemini-3-pro-image` |
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- | Cheap iteration | `google/gemini-3.1-flash-lite-image` (1K only), `openai/gpt-image-1-mini` |
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- | Photoreal control, reproducible seeds | `bytedance-seed/seedream-4.5` |
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- | Several images per request | `bytedance-seed/seedream-4.5`, `openai/gpt-image-2` (up to 10) |
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- | Vector / SVG output | `recraft/recraft-v4.1-vector` |
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- | Transparent background | `openai/gpt-image-1` with `--background transparent` |
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- | Legible text inside the image | `recraft/recraft-v4.1`, `sourceful/riverflow-v2.5-pro` — see the caveat below |
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-
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- `references/models.md` carries the full catalogue with per-model parameters, allowed values, and
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- prices. The live listing is authoritative and free:
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-
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- ```bash
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- python scripts/generate_image.py --list-models # every model and its allowed values
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- python scripts/generate_image.py --list-models gemini # filtered by substring
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- python scripts/generate_image.py --model-info openai/gpt-image-1 # one model, plus pricing
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- ```
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-
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- ## Parameter support varies by model
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-
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- This is the main thing to get right. Models advertise different parameter sets **and different
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- allowed values**, and sending something a model does not support is rejected, not ignored.
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-
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- The script checks the request against the live catalogue before spending anything, so a bad
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- parameter fails locally in under a second with the legal values printed:
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-
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- ```console
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- $ python scripts/generate_image.py "abstract pattern" -m openai/gpt-image-2 --background transparent
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- Error: Request rejected before billing (1 problem):
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- - background=transparent is not allowed; this model accepts: auto, opaque
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- ```
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-
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- Rough guide — but let the check be the authority, since the catalogue moves:
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-
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- - `--resolution` — Gemini, Seedream, Riverflow, Krea, Grok. The tiers differ: `512` only on Gemini
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- 3.1 Flash, `4K` on Gemini 3 Pro / Seedream / Riverflow, and **`1K` only** on
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- `gemini-3.1-flash-lite-image` and the Krea models.
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- - `--output-format` — Riverflow 2.5 only (`png`, `jpeg`, `webp`; the `fast` variant takes `jpeg`
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- alone). Gemini, OpenAI, Seedream, and Recraft all choose their own container.
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- - `--quality`, `--background`, `--output-compression` — the OpenAI family, plus `--background` on
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- Riverflow 2.5. **`--background transparent` is not available on `gpt-image-2` or
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- `gpt-5.4-image-2`** — use `gpt-image-1`, `gpt-image-1-mini`, `gpt-5-image`, or `gpt-5-image-mini`.
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- - `--seed` — Seedream and Krea. Not Gemini, not OpenAI.
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- - `--aspect-ratio` — nearly all models, but the enum differs sharply: `gpt-image-1` accepts only
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- `1:1`, `3:2`, `2:3`, `auto`, and `gpt-5-image*` does not accept it at all.
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- - `--n` — capped per model: 1 for Gemini, Riverflow, MAI and Grok, 6 for Recraft, 10 for Seedream
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- and OpenAI. The Krea models reject it outright.
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-
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- Pass `--dry-run` to validate and print the exact request body without generating or billing.
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- `--no-preflight` skips the check when you want the API itself to arbitrate.
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-
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- ## Writing the prompt
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-
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- Prompt quality decides output quality more than model choice does. Name, in one sentence each:
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-
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- 1. **Subject** — what is in frame, and how much of it. "A single pipette tip above a 96-well plate."
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- 2. **Medium and style** — photograph, watercolour, 3D render, flat vector, scientific illustration.
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- 3. **Lighting and palette** — "soft diffuse lighting, cool blue and white palette."
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- 4. **Composition** — "wide shot, subject left of centre, empty space on the right for a title."
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- 5. **What to avoid** — "no text, no labels, no watermark."
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-
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- Asking for empty space where a caption or title will go is the single most useful compositional
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- instruction for posters and slides.
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-
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- Iterate cheaply: draft on `gemini-3.1-flash-lite-image`, then regenerate the wording you settled on
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- with the model you actually want. To refine rather than restart, feed the last output back as a
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- reference (`-i out.png`) and describe only the change.
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-
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- ## Editing and reference images
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-
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- `-i/--input` is repeatable and accepts local paths, HTTP(S) URLs, or data URLs. Local files are
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- base64-encoded and sent as `input_references`.
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-
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- ```bash
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- # Single-image edit
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- python scripts/generate_image.py "Add sunglasses to the person" -i portrait.png
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-
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- # Composite several references
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- python scripts/generate_image.py "Blend these two styles" -i style_a.png -i style_b.jpg -o blend.png
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-
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- # Reference an image already on the web
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- python scripts/generate_image.py "Restyle as a watercolor" -i https://example.com/photo.jpg
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- ```
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-
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- Reference limits differ: 16 for OpenAI, 14 for Gemini and Seedream, 10 for `riverflow-v2*-pro`,
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- 3 for `gemini-2.5-flash-image` and Grok, 1 for Recraft, MAI, and Krea. Accepted local formats: PNG,
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- JPEG, GIF, WebP. Riverflow v2 bills $0.20 per reference image on top of the output.
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-
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- ## Worked examples
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-
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- The `-o` paths are destinations the script creates, not files bundled with the skill.
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-
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- ```bash
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- # Wide hero image for a poster, with space reserved for the title
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- python scripts/generate_image.py \
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- "Laboratory with modern equipment, photorealistic, well-lit, wide shot, \
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- equipment on the left, empty wall on the right, no text" \
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- --aspect-ratio 21:9 --resolution 2K -o poster/hero.png
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-
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- # Conceptual illustration for a manuscript — illustrative, never presented as data
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- python scripts/generate_image.py \
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- "Stylised illustration of immune cells surrounding a tumour cell, scientific illustration, \
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- cool palette, no text" \
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- --resolution 2K -o figures/immunotherapy_concept.png
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-
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- # Vector logo
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- python scripts/generate_image.py \
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- "Minimal geometric fox logo, two colors" \
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- -m recraft/recraft-v4.1-vector -o assets/logo.svg
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-
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- # Slide background with a transparent alpha channel
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- python scripts/generate_image.py \
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- "Abstract molecular pattern, subtle, blue and white, no text" \
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- -m openai/gpt-image-1 --background transparent -o slides/bg.png
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-
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- # Four variations in one request
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- python scripts/generate_image.py \
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- "Stylized neuron network illustration" \
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- -m bytedance-seed/seedream-4.5 --n 4 -o variations.png
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- # -> variations_1.png ... variations_4.png
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-
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- # Reproducible output
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- python scripts/generate_image.py "A cat astronaut" \
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- -m bytedance-seed/seedream-4.5 --seed 42
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-
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- # Check a request costs nothing to get wrong
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- python scripts/generate_image.py "A cat astronaut" --resolution 4K --dry-run
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- ```
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-
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- ## Script parameters
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-
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- | Flag | Purpose |
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- | --- | --- |
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- | `prompt` | Image description, or the edit to apply (required unless `--list-models` / `--model-info`) |
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- | `-m`, `--model` | Model slug (default `google/gemini-3.1-flash-image`) |
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- | `-o`, `--output` | Output path; extension defaults to the returned media type |
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- | `-i`, `--input` | Reference image — path, URL, or data URL. Repeatable |
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- | `--n` | Images per request, model-capped |
206
- | `--aspect-ratio` | `1:1`, `16:9`, `9:16`, `4:3`, `3:2`, `21:9`, … — enum differs per model |
207
- | `--resolution` | `512`, `1K`, `2K`, `4K` — tiers differ per model |
208
- | `--quality` | `auto`, `low`, `medium`, `high` (OpenAI) |
209
- | `--output-format` | `png`, `jpeg`, `webp` (Riverflow 2.5) |
210
- | `--background` | `auto`, `transparent`, `opaque` |
211
- | `--output-compression` | 0–100, OpenAI models |
212
- | `--seed` | Deterministic output where supported |
213
- | `--api-key` | Overrides the environment and `.env` |
214
- | `--timeout` | Request timeout, seconds (default 300) |
215
- | `--retries` | Retries for rate limits and 5xx responses (default 2) |
216
- | `--no-preflight` | Skip the free capability check before the billed request |
217
- | `--dry-run` | Validate and print the request, then exit without generating |
218
- | `--list-models` | Print the catalogue with allowed values, optionally filtered, then exit |
219
- | `--model-info` | Print one model's allowed values and pricing, then exit |
220
-
221
- There is no `--size`: no model in the catalogue accepts a `size` parameter. Shape output with
222
- `--aspect-ratio` and `--resolution`.
223
-
224
- ## API shape
225
-
226
- For direct requests without the script:
227
-
228
- ```bash
229
- curl -s https://openrouter.ai/api/v1/images \
230
- -H "Authorization: Bearer $OPENROUTER_API_KEY" \
231
- -H "Content-Type: application/json" \
232
- -d '{
233
- "model": "google/gemini-3.1-flash-image",
234
- "prompt": "A red bicycle against a white wall",
235
- "aspect_ratio": "16:9"
236
- }'
237
- ```
238
-
239
- Response:
240
-
241
- ```json
242
- {
243
- "created": 1748372400,
244
- "data": [{ "b64_json": "<base64>", "media_type": "image/png" }],
245
- "usage": {
246
- "prompt_tokens": 4,
247
- "completion_tokens": 1120,
248
- "total_tokens": 1124,
249
- "cost": 0.0672,
250
- "completion_tokens_details": { "image_tokens": 1120 }
251
- }
252
- }
253
- ```
254
-
255
- `b64_json` is raw base64, **not** a data URL. `media_type` reflects the real format, so honour it
256
- when naming files — vector models return `image/svg+xml`, and `gemini-3.1-flash-lite-image` returns
257
- JPEG rather than PNG.
258
-
259
- Streaming (`"stream": true`) emits `image_generation.partial_image`, `image_generation.completed`,
260
- and `error` events, terminating with `data: [DONE]`. Only the OpenAI models support it, and the
261
- bundled script does not use it.
262
-
263
- Billing is all-or-nothing: a generation is either completed and billed in full, or it fails and is
264
- not billed — so a rejected parameter costs nothing but time. Streaming preview frames are not
265
- charged separately. On a bring-your-own-key account `usage.cost` reads `0` and the real amount is
266
- in `cost_details.upstream_inference_cost`; the script reports that figure rather than claiming the
267
- run was free.
268
-
269
- ## Cost
270
-
271
- Per-image models are predictable: Seedream $0.04, Recraft v4.1 $0.035 (vector $0.08, pro $0.21),
272
- Riverflow 2.5 fast $0.019 and pro $0.13–0.17, Grok $0.05–0.07.
273
-
274
- Gemini, OpenAI, and MAI bill per output token, which scales with resolution — a 4K image costs
275
- roughly sixteen times a 1K one. Measured: one 1K `gemini-3.1-flash-lite-image` render is 1120
276
- output tokens, $0.034. At the same size `gemini-3.1-flash-image` is double that and
277
- `gemini-3-pro-image` four times. Draft at low resolution on a cheap model; pay for size once.
278
-
279
- ## Notes and caveats
280
-
281
- - **Models cannot be trusted with text.** Words inside a generated image come back misspelled,
282
- garbled, or invented. Ask for "no text" and overlay real type in LaTeX, PowerPoint, or HTML — or
283
- use `scientific-schematics` when labels are the point.
284
- - **A generated image is an illustration, never evidence.** It shows nothing that was measured.
285
- Never present one as microscopy, imaging, gel, or instrument output, never let it stand in for a
286
- figure that reports results, and label it as an illustration in captions. Nature and Science both
287
- require disclosure of generative-AI imagery, and several journals prohibit it outside
288
- clearly-marked concept art — check the target venue before submitting.
289
- - Generation is a paid API call. Prefer a cheap model and low resolution while iterating on wording.
290
- - Generation takes roughly 5–60 seconds depending on model and resolution.
291
- - Reference images are uploaded to OpenRouter. Do not send unpublished or sensitive data, patient
292
- images, or anything under embargo.
293
- - Never hardcode the API key. Keep it in the environment or an ignored `.env`.
294
- - Prompt specifically when editing: "change the sky to sunset colours" beats "edit the sky".
295
- - A refusal arrives as an HTTP 400 or 403 mentioning content policy, not as a bad image. Rephrase —
296
- clinical and anatomical subjects trip moderation more often than the request warrants.
297
- - Rate limits and 5xx responses are retried automatically; a 4xx is final, because the request
298
- itself is what needs changing.
299
-
300
- ## Related skills
301
-
302
- - `scientific-schematics` — technical diagrams, flowcharts, circuits, pathways
303
- - `scientific-slides` — presentations that embed generated visuals
304
- - `latex-posters` — posters that embed hero images
@@ -1,310 +0,0 @@
1
- ---
2
- name: geniml
3
- description: "Use Geniml for audited local genomic-interval workflows: validate BED and universe contracts, plan Region2Vec or scEmbed runs, inspect model/tokenizer compatibility, and assess consensus universes."
4
- license: MIT
5
- compatibility: Requires Python 3.10+ and uv. Guidance targets geniml 0.8.4 with gtars 0.9.2; ML workflows need the pinned ml extra and compatible native wheels. Bundled planners and inspectors are dependency-free, local-only, and make no network requests.
6
- allowed-tools: Read Write Edit Bash Glob
7
- metadata:
8
- version: "1.1"
9
- skill-author: "K-Dense Inc."
10
- upstream-version: "0.8.4"
11
- last-reviewed: "2026-07-23"
12
- ---
13
-
14
- # Geniml
15
-
16
- Use Geniml for machine learning and statistical workflows over genomic interval
17
- sets. Treat coordinates, assemblies, token vocabularies, model artifacts, and
18
- sample grouping as explicit contracts. The bundled scripts validate or plan;
19
- they do not import Geniml, contact services, deserialize models, or execute
20
- training.
21
-
22
- `Bash` is declared only for explicit, user-approved `uv`, Python, Geniml,
23
- Gtars, Git, and native CLI commands shown in this guide; bundled Python helpers
24
- do not spawn subprocesses. Example paths under `data/`, `refs/`, `work/`, and
25
- `models/` are user-provided project placeholders, not missing bundled files.
26
-
27
- ## Verified release snapshot
28
-
29
- - Latest stable PyPI release on 2026-07-23: `geniml==0.8.4` (2026-01-14).
30
- - PyPI does not declare `Requires-Python`; its classifiers list Python
31
- 3.10-3.14. Prefer Python 3.11 or 3.12 where all native/ML wheels resolve.
32
- - `geniml==0.8.4` accepts `gtars>=0.2.5`; the verified base smoke used current
33
- `gtars==0.9.2` (2026-06-17, Python >=3.10).
34
- - Extras are `ml` and `test`. The base install omits Torch, Gensim, Scanpy,
35
- Hugging Face Hub, pyBigWig, and HMM dependencies.
36
- - Upstream documentation contains stale examples. Release source and installed
37
- `--help` output take precedence where they conflict.
38
-
39
- ## Install reproducibly
40
-
41
- Use a project environment and commit its generated lockfile:
42
-
43
- ```bash
44
- uv venv --python 3.12
45
- uv pip install "geniml==0.8.4" "gtars==0.9.2"
46
- ```
47
-
48
- For Region2Vec, scEmbed, evaluation, or universe methods needing ML libraries:
49
-
50
- ```bash
51
- uv pip install "geniml[ml]==0.8.4" "gtars==0.9.2"
52
- ```
53
-
54
- For a durable project, prefer:
55
-
56
- ```bash
57
- uv add "geniml[ml]==0.8.4" "gtars==0.9.2"
58
- uv lock
59
- ```
60
-
61
- Do not install an unpinned Git branch. Record Python, OS/architecture, the
62
- resolved lockfile, and the PyPI artifact digest. Geniml itself is BSD-2-Clause;
63
- the `MIT` frontmatter value licenses this skill's content.
64
-
65
- ## Start with the safety gate
66
-
67
- Before importing Geniml or running an external binary:
68
-
69
- 1. Work only with explicit local regular files. Reject URLs, FIFOs, devices,
70
- and symlinks unless the user deliberately changes that policy.
71
- 2. Validate BED structure and the declared assembly against a trusted local
72
- chromosome-sizes file.
73
- 3. Bound file count, bytes, rows, workers, epochs, and output size.
74
- 4. Separate train/validation/test by patient, donor, biological replicate, or
75
- other independent unit—not by BED row or cell alone.
76
- 5. Inventory and checksum the universe, tokenizer, model, config, inputs,
77
- metadata manifest, and native binaries.
78
- 6. Obtain explicit approval before any BEDbase or Hugging Face download. Never
79
- infer approval from a model ID or BEDbase identifier.
80
- 7. Keep logs aggregate and bounded. BED filenames, sample IDs, phenotypes,
81
- labels, barcodes, and genomic intervals may be sensitive.
82
-
83
- ## Coordinate and assembly contract
84
-
85
- BED intervals are normally **0-based, half-open** `[start, end)`: start is
86
- included, end is excluded, and length is `end - start`. Do not mix them with
87
- 1-based closed coordinates from VCF/GFF or user-facing genome browsers.
88
-
89
- For every corpus and artifact, record:
90
-
91
- - assembly and patch/accession where possible (for example GRCh38 versus
92
- GRCh38.p14), plus the chromosome-sizes checksum;
93
- - contig naming convention (`chr1` versus `1`), alt/random/decoy policy, and
94
- mitochondrial naming;
95
- - coordinate convention, sorting order, duplicate/overlap policy, and whether
96
- BED strand is meaningful;
97
- - liftover tool, chain digest, source/target assemblies, unmapped fraction, and
98
- post-liftover validation.
99
-
100
- Reject negative coordinates, `end <= start`, integer overflow, unknown
101
- contigs, ends beyond contig length, malformed columns, mixed assemblies, and
102
- silent contig renaming. Sorting and normalization never repair an assembly
103
- mismatch. BED3 has no strand; when column 6 is present, preserve `+`, `-`, or
104
- `.` unless the assay contract says otherwise.
105
-
106
- Run a bounded validation and normalization **plan** before analysis:
107
-
108
- ```bash
109
- python skills/geniml/scripts/bed_validator.py \
110
- --input data/peaks.bed \
111
- --assembly GRCh38 \
112
- --chrom-sizes refs/GRCh38.chrom.sizes
113
- ```
114
-
115
- The validator reports proposed actions but never rewrites the BED file.
116
-
117
- ## Current API map
118
-
119
- ### Region and tokenizer I/O
120
-
121
- Prefer Gtars for new interval/tokenizer code:
122
-
123
- ```python
124
- from gtars.models import Region, RegionSet
125
- from gtars.tokenizers import Tokenizer
126
-
127
- regions = RegionSet("data/peaks.bed")
128
- tokenizer = Tokenizer.from_bed("refs/universe.bed")
129
- encoded = tokenizer(regions)
130
- input_ids = encoded["input_ids"]
131
- ```
132
-
133
- `RegionSet` and `Tokenizer` also accept remote inputs in some constructors;
134
- this skill permits local paths only unless network access is explicitly
135
- approved. `geniml.io.RegionSet(regions, backed=False)` remains available as a
136
- legacy Python implementation; backed sets are iterable but not indexable.
137
- `geniml.io.Region` uses `stop`, while `gtars.models.Region` uses `end`.
138
-
139
- With gtars 0.9.2, seven special tokens are added to a BED vocabulary. Therefore
140
- `len(tokenizer)` is not simply the number of universe rows. Preserve universe
141
- row order and the exact special-token map.
142
-
143
- ### Region2Vec
144
-
145
- The modern class lives at a concrete module path:
146
-
147
- ```python
148
- from geniml.region2vec.main import Region2VecExModel
149
- from geniml.region2vec.utils import Region2VecDataset
150
- from gtars.tokenizers import Tokenizer
151
-
152
- tokenizer = Tokenizer.from_bed("refs/universe.bed")
153
- dataset = Region2VecDataset("work/tokens.parquet", shuffle=True)
154
- model = Region2VecExModel(tokenizer=tokenizer, embedding_dim=100)
155
- model.train(dataset, epochs=10, window_size=5, num_cpus=4, seed=42)
156
- ```
157
-
158
- The Parquet input must contain one list-valued `tokens` column, one document
159
- per row. See [references/region2vec.md](references/region2vec.md) for export,
160
- encoding, legacy CLI, and evaluation details.
161
-
162
- ### scEmbed
163
-
164
- Import `ScEmbed` from `geniml.scembed.main`. AnnData `.var` must contain
165
- `chr`, `start`, and `end`; rows are cells and nonzero features identify
166
- accessible regions. Pre-tokenize to a Parquet `tokens` column and use the same
167
- Tokenizer for training and inference. See
168
- [references/scembed.md](references/scembed.md).
169
-
170
- ### BEDspace
171
-
172
- BEDspace remains in 0.8.4 and invokes an external StarSpace executable.
173
- StarSpace is archived and upstream Geniml does not pin a compatible revision.
174
- Treat BEDspace as a legacy reproduction path, not the default for new systems.
175
- See [references/bedspace.md](references/bedspace.md) for the exact stable CLI
176
- spelling and an immutable, explicitly unverified build baseline.
177
-
178
- ### Consensus universes and assessment
179
-
180
- The installed 0.8.4 CLI uses:
181
-
182
- ```text
183
- geniml build-universe {cc,ccf,ml,hmm} ...
184
- geniml assess-universe ...
185
- geniml eval {gdst,npt,ctt,rct,bin-gen} ...
186
- ```
187
-
188
- CC/CCF/ML/HMM consume precomputed coverage bigWigs. Do not concatenate or
189
- generate coverage until all BED files pass the same assembly contract.
190
- Assessment and embedding metrics are distinct: `assess-universe` measures fit
191
- of a universe to interval collections, while `eval` implements CTT, RCT, GDST,
192
- and NPT for embeddings. See
193
- [references/consensus_peaks.md](references/consensus_peaks.md) and
194
- [references/utilities.md](references/utilities.md).
195
-
196
- ## Important 0.8.4 migration notes
197
-
198
- - The 0.7.0 changelog moved new RegionSet/tokenizer work toward Gtars.
199
- - The 0.4.0 names `TreeTokenizer` and `AnnDataTokenizer` are historical; the
200
- current Gtars API exposes `Tokenizer`.
201
- - In the 0.8.4 wheel, `geniml.region2vec` and `geniml.scembed` do not re-export
202
- their modern classes/functions. Use the concrete module paths above.
203
- - `geniml tokenize` and `geniml region2vec` call names no longer exported by
204
- their package `__init__` files; do not build new workflows around those CLI
205
- paths without an installed-version smoke test.
206
- - `geniml scembed` parses legacy MatrixMarket options but its command body is a
207
- no-op in 0.8.4. Use `geniml.scembed.main.ScEmbed`.
208
- - Official pages still show `geniml assess`; the release command is
209
- `geniml assess-universe`.
210
- - `.gtok` remains present in legacy datasets, but upstream issue #14 proposes
211
- deprecating many-file `.gtok` workflows. Prefer one bounded Parquet corpus.
212
- - Config key `embedding_size` is accepted only for backward compatibility;
213
- use `embedding_dim`.
214
-
215
- ## Model and universe compatibility
216
-
217
- A Region2Vec/scEmbed inference bundle is valid only when these agree:
218
-
219
- - model `config.yaml` `vocab_size` and `embedding_dim`;
220
- - exact `universe.bed` bytes/order and assembly;
221
- - tokenizer implementation/version and special-token IDs;
222
- - checkpoint tensor shapes and pooling policy;
223
- - Geniml/Gtars versions and any tokenization parameters.
224
-
225
- Geniml 0.8.4 defaults to `checkpoint.pt`, `config.yaml`, and `universe.bed`.
226
- Its loader uses `torch.load(..., weights_only=True)`, but `.pt`, Gensim
227
- `.model`, pickle, joblib, and native binaries remain untrusted inputs. Inspect
228
- and checksum artifacts before loading; use an isolated environment and never
229
- load a checkpoint merely to discover its metadata.
230
-
231
- ```bash
232
- python skills/geniml/scripts/model_artifact_inspector.py \
233
- --model-dir models/region2vec
234
-
235
- python skills/geniml/scripts/tokenizer_compatibility.py \
236
- --model-dir models/region2vec \
237
- --universe refs/universe.bed \
238
- --assembly GRCh38
239
- ```
240
-
241
- `Region2VecExModel(model_path="org/repo")`, `ScEmbed(model_path="org/repo")`,
242
- and Gtars `Tokenizer.from_pretrained(...)` can download from Hugging Face.
243
- Local `from_pretrained("models/local")` loads a local bundle. Pin Hub revision
244
- and expected hashes when a user approves download; then work offline from the
245
- verified cache.
246
-
247
- ## BEDbase downloads and caches
248
-
249
- `BBClient.load_bed`, `load_bedset`, and token-cache operations may contact
250
- `https://api.bedbase.org`. The default cache is
251
- `$BBCLIENT_CACHE` or `~/.bbcache`; `BEDBASE_API` changes the endpoint. Do not
252
- read unrelated environment variables. Set an explicit project cache, estimate
253
- size, approve identifiers/endpoints, and verify returned checksums before use.
254
-
255
- Local inspection commands are safer:
256
-
257
- ```text
258
- geniml bbclient seek ID --cache-folder /absolute/project/cache
259
- geniml bbclient inspect-bedfiles --cache-folder /absolute/project/cache
260
- geniml bbclient inspect-bedsets --cache-folder /absolute/project/cache
261
- ```
262
-
263
- The `cache-bed`, `cache-bedset`, and `cache-tokens` subcommands may use the
264
- network. Do not run them implicitly or include sensitive local BED files in an
265
- upload/cache workflow.
266
-
267
- ## Local audit and planning CLIs
268
-
269
- All scripts are standard-library-only and default to redacted JSON:
270
-
271
- ```bash
272
- # Audit manifest paths, checksums, assemblies, and patient/donor leakage
273
- python skills/geniml/scripts/corpus_auditor.py \
274
- --manifest data/manifest.tsv --assembly-column assembly \
275
- --group-column patient_id --split-column split
276
-
277
- # Plan tokenizer/model compatibility checks
278
- python skills/geniml/scripts/tokenizer_compatibility.py \
279
- --model-dir models/r2v --universe refs/universe.bed --assembly GRCh38
280
-
281
- # Plan consensus construction; does not execute Geniml or coverage tools
282
- python skills/geniml/scripts/consensus_plan.py \
283
- --manifest data/manifest.tsv --chrom-sizes refs/GRCh38.chrom.sizes \
284
- --assembly GRCh38 --method cc --output-dir work/consensus
285
-
286
- # Plan an embedding run; does not import ML libraries
287
- python skills/geniml/scripts/embedding_plan.py \
288
- --mode region2vec --data work/tokens.parquet \
289
- --universe refs/universe.bed --output-dir work/r2v \
290
- --assembly GRCh38
291
- ```
292
-
293
- Use `--help` for resource limits and explicit path-disclosure controls.
294
-
295
- ## References
296
-
297
- - [Region2Vec](references/region2vec.md): modern API, artifacts, CLI drift,
298
- training, encoding, and evaluation.
299
- - [scEmbed](references/scembed.md): AnnData/token preparation, training,
300
- inference, annotation, privacy, and leakage.
301
- - [BEDspace](references/bedspace.md): metadata schema, exact legacy CLI,
302
- StarSpace status, artifacts, and retrieval.
303
- - [Consensus peaks](references/consensus_peaks.md): coverage prerequisites,
304
- CC/CCF/ML/HMM, assessment, and assembly safeguards.
305
- - [Utilities](references/utilities.md): I/O, Gtars tokenizers, BBClient,
306
- evaluation, model safety, migration, and dated sources.
307
-
308
- Source snapshot and primary-paper links are dated in
309
- [references/utilities.md](references/utilities.md). Re-check release metadata
310
- and installed signatures before changing the pinned versions.