@inflexa-ai/harness 0.1.1

package/dist/workflows/target-assessment/steps/phase2-aggregate.d.ts

@@ -0,0 +1,696 @@
+/**
+ * Phase 2 aggregator — schema definitions retained for downstream
+ * type-checking. The DBOS workflow assembles the Phase-2 bundle inline.
+ *
+ * The `failedTrialClassifier` and `offTargetCurator` keys present in
+ * earlier versions were removed as part of the
+ * `target-dossier-deep-synthesis` change — those steps were no-ops; their
+ * deterministic logic runs in Phase 4 (`classifyFailureReason`,
+ * `aggregateOffTargetPanel`). The bundle continues to expose them as
+ * coverage-tagged stubs so downstream code that still reads them
+ * compiles, but nothing populates them.
+ */
+import { z } from "zod";
+export declare const Phase2AggregateInputSchema: z.ZodObject<{
+    "decision-modulator-triage": z.ZodDiscriminatedUnion<[z.ZodObject<{
+        coverage: z.ZodLiteral<"available">;
+        data: z.ZodObject<{
+            shortlist: z.ZodArray<z.ZodObject<{
+                moleculeChemblId: z.ZodString;
+                preferredName: z.ZodString;
+                maxPhase: z.ZodNullable<z.ZodNumber>;
+                firstApproval: z.ZodNullable<z.ZodNumber>;
+                rationale: z.ZodString;
+            }, z.core.$strip>>;
+            notes: z.ZodString;
+            dropped_synonyms: z.ZodDefault<z.ZodArray<z.ZodObject<{
+                chemblId: z.ZodString;
+                reason: z.ZodEnum<{
+                    same_active_substance: "same_active_substance";
+                    ambiguous_name_synonym: "ambiguous_name_synonym";
+                }>;
+                keptId: z.ZodNullable<z.ZodString>;
+            }, z.core.$strip>>>;
+        }, z.core.$strip>;
+    }, z.core.$strip>, z.ZodObject<{
+        coverage: z.ZodLiteral<"queried_no_data">;
+        error: z.ZodOptional<z.ZodObject<{
+            message: z.ZodString;
+            name: z.ZodOptional<z.ZodString>;
+            stack: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>>;
+    }, z.core.$strip>, z.ZodObject<{
+        coverage: z.ZodLiteral<"not_loaded">;
+        reason: z.ZodOptional<z.ZodString>;
+    }, z.core.$strip>], "coverage">;
+    "decision-drugs-in-class": z.ZodDiscriminatedUnion<[z.ZodObject<{
+        coverage: z.ZodLiteral<"available">;
+        data: z.ZodObject<{
+            drugs: z.ZodArray<z.ZodObject<{
+                moleculeChemblId: z.ZodString;
+                preferredName: z.ZodString;
+                maxPhase: z.ZodNullable<z.ZodNumber>;
+                firstApproval: z.ZodNullable<z.ZodNumber>;
+                moleculeType: z.ZodNullable<z.ZodString>;
+                sources: z.ZodArray<z.ZodEnum<{
+                    chembl: "chembl";
+                    dgidb: "dgidb";
+                    drugbank: "drugbank";
+                }>>;
+            }, z.core.$strip>>;
+            total: z.ZodNumber;
+            truncated: z.ZodBoolean;
+        }, z.core.$strip>;
+    }, z.core.$strip>, z.ZodObject<{
+        coverage: z.ZodLiteral<"queried_no_data">;
+        error: z.ZodOptional<z.ZodObject<{
+            message: z.ZodString;
+            name: z.ZodOptional<z.ZodString>;
+            stack: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>>;
+    }, z.core.$strip>, z.ZodObject<{
+        coverage: z.ZodLiteral<"not_loaded">;
+        reason: z.ZodOptional<z.ZodString>;
+    }, z.core.$strip>], "coverage">;
+}, z.core.$strip>;
+export declare const Phase2BundleSchema: z.ZodObject<{
+    phase1: z.ZodObject<{
+        resolved: z.ZodObject<{
+            assessmentId: z.ZodString;
+            goal: z.ZodNullable<z.ZodString>;
+            canonicalId: z.ZodString;
+            canonicalOntology: z.ZodEnum<{
+                ensembl: "ensembl";
+                hgnc: "hgnc";
+            }>;
+            geneSymbol: z.ZodString;
+            approvedName: z.ZodString;
+            ids: z.ZodObject<{
+                hgnc: z.ZodNullable<z.ZodString>;
+                ensembl: z.ZodNullable<z.ZodString>;
+                uniprot: z.ZodNullable<z.ZodString>;
+                chembl: z.ZodNullable<z.ZodString>;
+                entrez: z.ZodNullable<z.ZodString>;
+            }, z.core.$strip>;
+            synonyms: z.ZodArray<z.ZodString>;
+            proteinSynonyms: z.ZodArray<z.ZodString>;
+            proteinFamily: z.ZodNullable<z.ZodString>;
+            resolutionCoverage: z.ZodObject<{
+                hgnc: z.ZodBoolean;
+                uniprot: z.ZodBoolean;
+                ensembl: z.ZodBoolean;
+                chembl: z.ZodBoolean;
+            }, z.core.$strip>;
+        }, z.core.$strip>;
+        collectors: z.ZodObject<{
+            opentargets: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    ensemblId: z.ZodString;
+                    approvedSymbol: z.ZodString;
+                    approvedName: z.ZodString;
+                    tractability: z.ZodNullable<z.ZodObject<{
+                        smallMolecule: z.ZodNullable<z.ZodBoolean>;
+                        antibody: z.ZodNullable<z.ZodBoolean>;
+                        otherModalities: z.ZodNullable<z.ZodBoolean>;
+                    }, z.core.$strip>>;
+                    associations: z.ZodArray<z.ZodObject<{
+                        diseaseId: z.ZodString;
+                        diseaseName: z.ZodString;
+                        score: z.ZodNumber;
+                        geneticAssociationScore: z.ZodNullable<z.ZodNumber>;
+                        knownDrugScore: z.ZodNullable<z.ZodNumber>;
+                        literatureScore: z.ZodNullable<z.ZodNumber>;
+                        animalModelScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
+                        somaticMutationScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
+                        literaturePmids: z.ZodDefault<z.ZodArray<z.ZodString>>;
+                    }, z.core.$strip>>;
+                    safetyLiabilities: z.ZodArray<z.ZodObject<{
+                        event: z.ZodString;
+                        biosamples: z.ZodArray<z.ZodString>;
+                        effects: z.ZodNullable<z.ZodString>;
+                        source: z.ZodString;
+                    }, z.core.$strip>>;
+                    baselineExpression: z.ZodArray<z.ZodObject<{
+                        tissueId: z.ZodString;
+                        tissueLabel: z.ZodString;
+                        organSystem: z.ZodNullable<z.ZodString>;
+                        rna: z.ZodNullable<z.ZodObject<{
+                            value: z.ZodNumber;
+                            unit: z.ZodString;
+                        }, z.core.$strip>>;
+                        protein: z.ZodNullable<z.ZodObject<{
+                            level: z.ZodNullable<z.ZodNumber>;
+                        }, z.core.$strip>>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            chemblModulators: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    targetChemblId: z.ZodNullable<z.ZodString>;
+                    modulators: z.ZodArray<z.ZodObject<{
+                        moleculeChemblId: z.ZodString;
+                        parentChemblId: z.ZodNullable<z.ZodString>;
+                        preferredName: z.ZodNullable<z.ZodString>;
+                        maxPhase: z.ZodNullable<z.ZodNumber>;
+                        moleculeType: z.ZodNullable<z.ZodString>;
+                        firstApproval: z.ZodNullable<z.ZodNumber>;
+                        evidence_source: z.ZodOptional<z.ZodLiteral<"chembl_activity">>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            ctgov: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    active: z.ZodArray<z.ZodObject<{
+                        nctId: z.ZodString;
+                        title: z.ZodString;
+                        officialTitle: z.ZodNullable<z.ZodString>;
+                        status: z.ZodString;
+                        phase: z.ZodNullable<z.ZodString>;
+                        studyType: z.ZodNullable<z.ZodString>;
+                        primaryPurpose: z.ZodNullable<z.ZodString>;
+                        conditions: z.ZodArray<z.ZodString>;
+                        interventions: z.ZodArray<z.ZodString>;
+                        interventionDetails: z.ZodArray<z.ZodObject<{
+                            name: z.ZodString;
+                            type: z.ZodNullable<z.ZodString>;
+                            description: z.ZodNullable<z.ZodString>;
+                            otherNames: z.ZodArray<z.ZodString>;
+                        }, z.core.$strip>>;
+                        enrollmentCount: z.ZodNullable<z.ZodNumber>;
+                        startDate: z.ZodNullable<z.ZodString>;
+                        primaryCompletionDate: z.ZodNullable<z.ZodString>;
+                        whyStopped: z.ZodNullable<z.ZodString>;
+                        briefSummary: z.ZodNullable<z.ZodString>;
+                        detailedDescription: z.ZodNullable<z.ZodString>;
+                        sponsor: z.ZodNullable<z.ZodString>;
+                        collection_query: z.ZodOptional<z.ZodString>;
+                        collection_channel: z.ZodOptional<z.ZodEnum<{
+                            class_modulator: "class_modulator";
+                            target_symbol: "target_symbol";
+                            therapeutic_program: "therapeutic_program";
+                            biomarker_context: "biomarker_context";
+                            failed_intervention: "failed_intervention";
+                        }>>;
+                    }, z.core.$strip>>;
+                    failed: z.ZodArray<z.ZodObject<{
+                        nctId: z.ZodString;
+                        title: z.ZodString;
+                        officialTitle: z.ZodNullable<z.ZodString>;
+                        status: z.ZodString;
+                        phase: z.ZodNullable<z.ZodString>;
+                        studyType: z.ZodNullable<z.ZodString>;
+                        primaryPurpose: z.ZodNullable<z.ZodString>;
+                        conditions: z.ZodArray<z.ZodString>;
+                        interventions: z.ZodArray<z.ZodString>;
+                        interventionDetails: z.ZodArray<z.ZodObject<{
+                            name: z.ZodString;
+                            type: z.ZodNullable<z.ZodString>;
+                            description: z.ZodNullable<z.ZodString>;
+                            otherNames: z.ZodArray<z.ZodString>;
+                        }, z.core.$strip>>;
+                        enrollmentCount: z.ZodNullable<z.ZodNumber>;
+                        startDate: z.ZodNullable<z.ZodString>;
+                        primaryCompletionDate: z.ZodNullable<z.ZodString>;
+                        whyStopped: z.ZodNullable<z.ZodString>;
+                        briefSummary: z.ZodNullable<z.ZodString>;
+                        detailedDescription: z.ZodNullable<z.ZodString>;
+                        sponsor: z.ZodNullable<z.ZodString>;
+                        collection_query: z.ZodOptional<z.ZodString>;
+                        collection_channel: z.ZodOptional<z.ZodEnum<{
+                            class_modulator: "class_modulator";
+                            target_symbol: "target_symbol";
+                            therapeutic_program: "therapeutic_program";
+                            biomarker_context: "biomarker_context";
+                            failed_intervention: "failed_intervention";
+                        }>>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            faersByTarget: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    drugProbed: z.ZodString;
+                    totalReports: z.ZodNullable<z.ZodNumber>;
+                    topReactions: z.ZodArray<z.ZodObject<{
+                        reaction: z.ZodString;
+                        count: z.ZodNumber;
+                    }, z.core.$strip>>;
+                    seriousness: z.ZodNullable<z.ZodObject<{
+                        totalReports: z.ZodNumber;
+                        fatalCount: z.ZodNumber;
+                        hospitalizationCount: z.ZodNumber;
+                        lifeThreateningCount: z.ZodNumber;
+                        disablingCount: z.ZodNumber;
+                        congenitalAnomalyCount: z.ZodDefault<z.ZodNumber>;
+                        otherSeriousCount: z.ZodDefault<z.ZodNumber>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            expressionHuman: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    source: z.ZodEnum<{
+                        gtex: "gtex";
+                        hpa_consensus: "hpa_consensus";
+                        hpa_rna_tissue: "hpa_rna_tissue";
+                    }>;
+                    unit: z.ZodEnum<{
+                        tpm: "tpm";
+                        ntpm: "ntpm";
+                        consensus_normalized: "consensus_normalized";
+                    }>;
+                    normalization_notes: z.ZodString;
+                    tissues: z.ZodArray<z.ZodObject<{
+                        tissueLabel: z.ZodString;
+                        organSystem: z.ZodNullable<z.ZodString>;
+                        value: z.ZodNullable<z.ZodNumber>;
+                        protein: z.ZodNullable<z.ZodNumber>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            expressionMultiSpecies: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    geneSymbol: z.ZodString;
+                    humanEnsemblId: z.ZodNullable<z.ZodString>;
+                    bySpecies: z.ZodArray<z.ZodObject<{
+                        species: z.ZodString;
+                        taxonId: z.ZodNumber;
+                        ensemblId: z.ZodString;
+                        source: z.ZodString;
+                        unit: z.ZodString;
+                        normalization_notes: z.ZodString;
+                        tissues: z.ZodArray<z.ZodObject<{
+                            tissue: z.ZodString;
+                            rank: z.ZodEnum<{
+                                high: "high";
+                                medium: "medium";
+                                low: "low";
+                                absent: "absent";
+                            }>;
+                            expressionScore: z.ZodNullable<z.ZodNumber>;
+                        }, z.core.$strip>>;
+                    }, z.core.$strip>>;
+                    notFound: z.ZodArray<z.ZodString>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            clinvar: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    totalFound: z.ZodNumber;
+                    variants: z.ZodArray<z.ZodObject<{
+                        variationId: z.ZodString;
+                        title: z.ZodString;
+                        clinicalSignificance: z.ZodString;
+                        reviewStatus: z.ZodString;
+                        conditions: z.ZodArray<z.ZodString>;
+                        molecularConsequence: z.ZodString;
+                        accession: z.ZodString;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            cbioportal: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    entrezGeneId: z.ZodNullable<z.ZodNumber>;
+                    rows: z.ZodArray<z.ZodObject<{
+                        cancerTypeId: z.ZodString;
+                        cancerTypeName: z.ZodString;
+                        totalSamples: z.ZodNumber;
+                        mutatedSamples: z.ZodNumber;
+                        frequency: z.ZodNumber;
+                        studies: z.ZodArray<z.ZodString>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            impc: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    mouseMarkerSymbol: z.ZodNullable<z.ZodString>;
+                    mgiAccessionId: z.ZodNullable<z.ZodString>;
+                    viability: z.ZodNullable<z.ZodEnum<{
+                        lethal_pre_weaning: "lethal_pre_weaning";
+                        subviable: "subviable";
+                        viable: "viable";
+                    }>>;
+                    viabilityCalls: z.ZodArray<z.ZodObject<{
+                        zygosity: z.ZodString;
+                        parameterStableId: z.ZodString;
+                        mpTerm: z.ZodNullable<z.ZodObject<{
+                            id: z.ZodString;
+                            name: z.ZodString;
+                        }, z.core.$strip>>;
+                    }, z.core.$strip>>;
+                    mpTerms: z.ZodArray<z.ZodObject<{
+                        id: z.ZodString;
+                        term: z.ZodString;
+                        bestPValue: z.ZodNullable<z.ZodNumber>;
+                    }, z.core.$strip>>;
+                    organSystems: z.ZodArray<z.ZodString>;
+                    sexDimorphic: z.ZodBoolean;
+                    phenotypeCount: z.ZodNumber;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            pubmedIndex: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    totalFound: z.ZodNumber;
+                    topPmids: z.ZodArray<z.ZodString>;
+                    results: z.ZodArray<z.ZodObject<{
+                        pmid: z.ZodString;
+                        title: z.ZodString;
+                        journal: z.ZodString;
+                        year: z.ZodString;
+                        authors: z.ZodString;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            pathways: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    pathways: z.ZodArray<z.ZodObject<{
+                        id: z.ZodString;
+                        name: z.ZodString;
+                        source: z.ZodEnum<{
+                            kegg: "kegg";
+                            reactome: "reactome";
+                        }>;
+                        url: z.ZodOptional<z.ZodString>;
+                        entity_uniprots: z.ZodOptional<z.ZodArray<z.ZodString>>;
+                        metadata: z.ZodOptional<z.ZodObject<{
+                            species_present: z.ZodOptional<z.ZodArray<z.ZodString>>;
+                        }, z.core.$strip>>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            stringPpi: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    partners: z.ZodArray<z.ZodObject<{
+                        proteinA: z.ZodString;
+                        proteinB: z.ZodString;
+                        score: z.ZodNumber;
+                        experimentalScore: z.ZodOptional<z.ZodNumber>;
+                        databaseScore: z.ZodOptional<z.ZodNumber>;
+                        textminingScore: z.ZodOptional<z.ZodNumber>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            familyComplexes: z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    primaryTargetGene: z.ZodString;
+                    primaryTargetUniprot: z.ZodNullable<z.ZodString>;
+                    accessoryProteinNames: z.ZodArray<z.ZodString>;
+                    complexes: z.ZodArray<z.ZodObject<{
+                        complexName: z.ZodString;
+                        complexId: z.ZodNullable<z.ZodNumber>;
+                        accessoryNames: z.ZodArray<z.ZodString>;
+                        subunitNames: z.ZodArray<z.ZodString>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">;
+            therapeuticPrograms: z.ZodOptional<z.ZodDiscriminatedUnion<[z.ZodObject<{
+                coverage: z.ZodLiteral<"available">;
+                data: z.ZodObject<{
+                    programs: z.ZodArray<z.ZodObject<{
+                        programId: z.ZodString;
+                        name: z.ZodString;
+                        targetSymbol: z.ZodString;
+                        targetUniprot: z.ZodNullable<z.ZodString>;
+                        modality: z.ZodString;
+                        sponsor: z.ZodNullable<z.ZodString>;
+                        mechanism: z.ZodString;
+                        status: z.ZodString;
+                        nctIds: z.ZodArray<z.ZodString>;
+                        pmids: z.ZodArray<z.ZodString>;
+                        evidence: z.ZodArray<z.ZodObject<{
+                            pmid: z.ZodOptional<z.ZodString>;
+                            doi: z.ZodOptional<z.ZodString>;
+                            source: z.ZodString;
+                            predicate: z.ZodOptional<z.ZodString>;
+                            score: z.ZodOptional<z.ZodNumber>;
+                            strength: z.ZodOptional<z.ZodString>;
+                            is_human: z.ZodOptional<z.ZodBoolean>;
+                            is_clinical: z.ZodOptional<z.ZodBoolean>;
+                            excerpt: z.ZodOptional<z.ZodString>;
+                            metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
+                            regulatory_reference: z.ZodOptional<z.ZodObject<{
+                                document: z.ZodString;
+                                section: z.ZodOptional<z.ZodString>;
+                                doc_id: z.ZodOptional<z.ZodString>;
+                                doc_url: z.ZodOptional<z.ZodString>;
+                            }, z.core.$strip>>;
+                        }, z.core.$strip>>;
+                        confidence: z.ZodEnum<{
+                            high: "high";
+                            medium: "medium";
+                            low: "low";
+                        }>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"queried_no_data">;
+                error: z.ZodOptional<z.ZodObject<{
+                    message: z.ZodString;
+                    name: z.ZodOptional<z.ZodString>;
+                    stack: z.ZodOptional<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>, z.ZodObject<{
+                coverage: z.ZodLiteral<"not_loaded">;
+                reason: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>], "coverage">>;
+        }, z.core.$strip>;
+    }, z.core.$strip>;
+    decisions: z.ZodObject<{
+        modulatorTriage: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                shortlist: z.ZodArray<z.ZodObject<{
+                    moleculeChemblId: z.ZodString;
+                    preferredName: z.ZodString;
+                    maxPhase: z.ZodNullable<z.ZodNumber>;
+                    firstApproval: z.ZodNullable<z.ZodNumber>;
+                    rationale: z.ZodString;
+                }, z.core.$strip>>;
+                notes: z.ZodString;
+                dropped_synonyms: z.ZodDefault<z.ZodArray<z.ZodObject<{
+                    chemblId: z.ZodString;
+                    reason: z.ZodEnum<{
+                        same_active_substance: "same_active_substance";
+                        ambiguous_name_synonym: "ambiguous_name_synonym";
+                    }>;
+                    keptId: z.ZodNullable<z.ZodString>;
+                }, z.core.$strip>>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        failedTrialClassifier: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                classifications: z.ZodDefault<z.ZodArray<z.ZodUnknown>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        offTargetCurator: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                panel: z.ZodDefault<z.ZodArray<z.ZodUnknown>>;
+                total: z.ZodDefault<z.ZodNumber>;
+                truncated: z.ZodDefault<z.ZodBoolean>;
+                notes: z.ZodDefault<z.ZodString>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        drugsInClass: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                drugs: z.ZodArray<z.ZodObject<{
+                    moleculeChemblId: z.ZodString;
+                    preferredName: z.ZodString;
+                    maxPhase: z.ZodNullable<z.ZodNumber>;
+                    firstApproval: z.ZodNullable<z.ZodNumber>;
+                    moleculeType: z.ZodNullable<z.ZodString>;
+                    sources: z.ZodArray<z.ZodEnum<{
+                        chembl: "chembl";
+                        dgidb: "dgidb";
+                        drugbank: "drugbank";
+                    }>>;
+                }, z.core.$strip>>;
+                total: z.ZodNumber;
+                truncated: z.ZodBoolean;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+    }, z.core.$strip>;
+}, z.core.$strip>;
+export type Phase2Bundle = z.infer<typeof Phase2BundleSchema>;