@inflexa-ai/harness 0.1.1

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Files changed (823) hide show
  1. package/LICENSE +202 -0
  2. package/NOTICE +5 -0
  3. package/README.md +58 -0
  4. package/dist/agents/conversation-agent.d.ts +105 -0
  5. package/dist/agents/conversation-agent.js +140 -0
  6. package/dist/agents/report-builder.d.ts +32 -0
  7. package/dist/agents/report-builder.js +31 -0
  8. package/dist/agents/sandbox/__fixtures__/deps.d.ts +23 -0
  9. package/dist/agents/sandbox/__fixtures__/deps.js +96 -0
  10. package/dist/agents/sandbox/bulk-transcriptomics-agent.d.ts +8 -0
  11. package/dist/agents/sandbox/bulk-transcriptomics-agent.js +22 -0
  12. package/dist/agents/sandbox/cheminformatics-agent.d.ts +9 -0
  13. package/dist/agents/sandbox/cheminformatics-agent.js +62 -0
  14. package/dist/agents/sandbox/chromatin-agent.d.ts +8 -0
  15. package/dist/agents/sandbox/chromatin-agent.js +24 -0
  16. package/dist/agents/sandbox/data-profiler.d.ts +10 -0
  17. package/dist/agents/sandbox/data-profiler.js +24 -0
  18. package/dist/agents/sandbox/dna-methylation-agent.d.ts +8 -0
  19. package/dist/agents/sandbox/dna-methylation-agent.js +24 -0
  20. package/dist/agents/sandbox/drug-repurposing-agent.d.ts +8 -0
  21. package/dist/agents/sandbox/drug-repurposing-agent.js +54 -0
  22. package/dist/agents/sandbox/enrichment-agent.d.ts +8 -0
  23. package/dist/agents/sandbox/enrichment-agent.js +24 -0
  24. package/dist/agents/sandbox/ephemeral-executor.d.ts +9 -0
  25. package/dist/agents/sandbox/ephemeral-executor.js +29 -0
  26. package/dist/agents/sandbox/genomic-variant-agent.d.ts +8 -0
  27. package/dist/agents/sandbox/genomic-variant-agent.js +27 -0
  28. package/dist/agents/sandbox/immune-profiling-agent.d.ts +8 -0
  29. package/dist/agents/sandbox/immune-profiling-agent.js +43 -0
  30. package/dist/agents/sandbox/index.d.ts +31 -0
  31. package/dist/agents/sandbox/index.js +96 -0
  32. package/dist/agents/sandbox/metabolomics-agent.d.ts +8 -0
  33. package/dist/agents/sandbox/metabolomics-agent.js +15 -0
  34. package/dist/agents/sandbox/microbiome-agent.d.ts +8 -0
  35. package/dist/agents/sandbox/microbiome-agent.js +15 -0
  36. package/dist/agents/sandbox/multi-omics-integration-agent.d.ts +8 -0
  37. package/dist/agents/sandbox/multi-omics-integration-agent.js +33 -0
  38. package/dist/agents/sandbox/multimodal-sc-agent.d.ts +8 -0
  39. package/dist/agents/sandbox/multimodal-sc-agent.js +15 -0
  40. package/dist/agents/sandbox/network-agent.d.ts +8 -0
  41. package/dist/agents/sandbox/network-agent.js +25 -0
  42. package/dist/agents/sandbox/pkpd-clinical-response-agent.d.ts +8 -0
  43. package/dist/agents/sandbox/pkpd-clinical-response-agent.js +59 -0
  44. package/dist/agents/sandbox/proteomics-agent.d.ts +8 -0
  45. package/dist/agents/sandbox/proteomics-agent.js +15 -0
  46. package/dist/agents/sandbox/scientific-executor.d.ts +9 -0
  47. package/dist/agents/sandbox/scientific-executor.js +56 -0
  48. package/dist/agents/sandbox/shared.d.ts +100 -0
  49. package/dist/agents/sandbox/shared.js +195 -0
  50. package/dist/agents/sandbox/single-cell-agent.d.ts +8 -0
  51. package/dist/agents/sandbox/single-cell-agent.js +25 -0
  52. package/dist/agents/sandbox/spatial-omics-agent.d.ts +8 -0
  53. package/dist/agents/sandbox/spatial-omics-agent.js +15 -0
  54. package/dist/agents/sandbox/statistical-modeling-agent.d.ts +8 -0
  55. package/dist/agents/sandbox/statistical-modeling-agent.js +37 -0
  56. package/dist/agents/sandbox/translational-safety-agent.d.ts +8 -0
  57. package/dist/agents/sandbox/translational-safety-agent.js +59 -0
  58. package/dist/agents/sandbox/types.d.ts +34 -0
  59. package/dist/agents/sandbox/types.js +15 -0
  60. package/dist/agents/sandbox/validate-skills.d.ts +18 -0
  61. package/dist/agents/sandbox/validate-skills.js +40 -0
  62. package/dist/agents/sandbox-catalog.d.ts +33 -0
  63. package/dist/agents/sandbox-catalog.js +44 -0
  64. package/dist/agents/system-prompt.d.ts +25 -0
  65. package/dist/agents/system-prompt.js +23 -0
  66. package/dist/app/chat-turn.d.ts +35 -0
  67. package/dist/app/chat-turn.js +64 -0
  68. package/dist/app/data-profile-policy.d.ts +36 -0
  69. package/dist/app/data-profile-policy.js +37 -0
  70. package/dist/app/message-assembly.d.ts +65 -0
  71. package/dist/app/message-assembly.js +61 -0
  72. package/dist/app/synthesize-run.d.ts +57 -0
  73. package/dist/app/synthesize-run.js +103 -0
  74. package/dist/auth/local-auth-context.d.ts +19 -0
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  76. package/dist/auth/local-run-authorizer.d.ts +10 -0
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  78. package/dist/auth/types.d.ts +166 -0
  79. package/dist/auth/types.js +61 -0
  80. package/dist/billing/cached-resolver.d.ts +23 -0
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  82. package/dist/billing/noop-resolver.d.ts +6 -0
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  88. package/dist/billing/run-charge.d.ts +24 -0
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  90. package/dist/config/resource-limits.d.ts +76 -0
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  92. package/dist/contracts/analogy-report.d.ts +120 -0
  93. package/dist/contracts/analogy-report.js +50 -0
  94. package/dist/contracts/chat-events.d.ts +61 -0
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  100. package/dist/contracts/index.d.ts +12 -0
  101. package/dist/contracts/index.js +5 -0
  102. package/dist/contracts/message.d.ts +36 -0
  103. package/dist/contracts/message.js +9 -0
  104. package/dist/contracts/part-registry.d.ts +18 -0
  105. package/dist/contracts/part-registry.js +28 -0
  106. package/dist/contracts/schemas/chat-events.d.ts +90 -0
  107. package/dist/contracts/schemas/chat-events.js +43 -0
  108. package/dist/contracts/schemas/chat-parts.d.ts +683 -0
  109. package/dist/contracts/schemas/chat-parts.js +295 -0
  110. package/dist/contracts/schemas/index.d.ts +2 -0
  111. package/dist/contracts/schemas/index.js +2 -0
  112. package/dist/contracts/target-assessment-row.d.ts +85 -0
  113. package/dist/contracts/target-assessment-row.js +37 -0
  114. package/dist/contracts/target-dossier.d.ts +16720 -0
  115. package/dist/contracts/target-dossier.js +1339 -0
  116. package/dist/data/clinical-benchmarks.json +108 -0
  117. package/dist/data/protein-family-modality.json +101 -0
  118. package/dist/data/safety-panel-schema.d.ts +64 -0
  119. package/dist/data/safety-panel-schema.js +34 -0
  120. package/dist/data/safety-panel.json +436 -0
  121. package/dist/execution/artifact-metadata.d.ts +74 -0
  122. package/dist/execution/artifact-metadata.js +203 -0
  123. package/dist/execution/artifact-record.d.ts +19 -0
  124. package/dist/execution/artifact-record.js +7 -0
  125. package/dist/execution/artifact-registration.d.ts +36 -0
  126. package/dist/execution/artifact-registration.js +61 -0
  127. package/dist/execution/artifact-registry.d.ts +82 -0
  128. package/dist/execution/artifact-registry.js +17 -0
  129. package/dist/execution/dbos-run-launcher.d.ts +7 -0
  130. package/dist/execution/dbos-run-launcher.js +38 -0
  131. package/dist/execution/ephemeral-runner.d.ts +81 -0
  132. package/dist/execution/ephemeral-runner.js +161 -0
  133. package/dist/execution/filesystem-artifact-registry.d.ts +57 -0
  134. package/dist/execution/filesystem-artifact-registry.js +92 -0
  135. package/dist/execution/noop-artifact-registry.d.ts +11 -0
  136. package/dist/execution/noop-artifact-registry.js +17 -0
  137. package/dist/execution/post-step-pipeline.d.ts +70 -0
  138. package/dist/execution/post-step-pipeline.js +207 -0
  139. package/dist/execution/post-step.d.ts +20 -0
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  141. package/dist/execution/reconcile-manifest.d.ts +25 -0
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  143. package/dist/execution/report-render.d.ts +39 -0
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  145. package/dist/execution/report-runner.d.ts +87 -0
  146. package/dist/execution/report-runner.js +227 -0
  147. package/dist/execution/run-authorizer.d.ts +43 -0
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  149. package/dist/execution/run-launcher.d.ts +36 -0
  150. package/dist/execution/run-launcher.js +15 -0
  151. package/dist/execution/run-synthesis.d.ts +107 -0
  152. package/dist/execution/run-synthesis.js +329 -0
  153. package/dist/execution/staged-input.d.ts +41 -0
  154. package/dist/execution/staged-input.js +15 -0
  155. package/dist/execution/step-summary-metrics.d.ts +10 -0
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  157. package/dist/execution/step-summary.d.ts +55 -0
  158. package/dist/execution/step-summary.js +106 -0
  159. package/dist/execution/topo-sort.d.ts +33 -0
  160. package/dist/execution/topo-sort.js +99 -0
  161. package/dist/index.d.ts +112 -0
  162. package/dist/index.js +157 -0
  163. package/dist/input-sanitization.d.ts +22 -0
  164. package/dist/input-sanitization.js +64 -0
  165. package/dist/lib/async-utils.d.ts +10 -0
  166. package/dist/lib/async-utils.js +24 -0
  167. package/dist/lib/chrome.d.ts +15 -0
  168. package/dist/lib/chrome.js +95 -0
  169. package/dist/lib/db-result.d.ts +93 -0
  170. package/dist/lib/db-result.js +197 -0
  171. package/dist/lib/fs-helpers.d.ts +74 -0
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  173. package/dist/lib/fs-result.d.ts +98 -0
  174. package/dist/lib/fs-result.js +137 -0
  175. package/dist/lib/host-concurrency.d.ts +16 -0
  176. package/dist/lib/host-concurrency.js +60 -0
  177. package/dist/lib/identifiers.d.ts +8 -0
  178. package/dist/lib/identifiers.js +10 -0
  179. package/dist/lib/metrics.d.ts +7 -0
  180. package/dist/lib/metrics.js +12 -0
  181. package/dist/lib/mime-detect.d.ts +17 -0
  182. package/dist/lib/mime-detect.js +29 -0
  183. package/dist/lib/otel.d.ts +30 -0
  184. package/dist/lib/otel.js +102 -0
  185. package/dist/lib/regulatory-corpus/fetch-fda-guidance.d.ts +35 -0
  186. package/dist/lib/regulatory-corpus/fetch-fda-guidance.js +107 -0
  187. package/dist/lib/regulatory-corpus/fetch-ich.d.ts +46 -0
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  189. package/dist/lib/regulatory-corpus.d.ts +88 -0
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  191. package/dist/lib/result.d.ts +87 -0
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  193. package/dist/lib/storage.d.ts +29 -0
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  197. package/dist/lib/trace-context.d.ts +11 -0
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  199. package/dist/loop/__fixtures__/scripted-provider.d.ts +31 -0
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  201. package/dist/loop/budget-exceeded.d.ts +22 -0
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  203. package/dist/loop/metrics.d.ts +25 -0
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  205. package/dist/loop/run-agent.d.ts +28 -0
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  211. package/dist/loop/types.d.ts +95 -0
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  213. package/dist/memory/ai-sdk-message-storage.d.ts +20 -0
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  235. package/dist/prompts/analogical-reasoner.d.ts +1 -0
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  237. package/dist/prompts/conversation.d.ts +1 -0
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  239. package/dist/prompts/execute-analysis/step-summary.d.ts +1 -0
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  249. package/dist/prompts/sandbox/cheminformatics-agent.d.ts +1 -0
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  255. package/dist/prompts/sandbox/dna-methylation-agent.d.ts +1 -0
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  257. package/dist/prompts/sandbox/drug-repurposing-agent.d.ts +1 -0
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  259. package/dist/prompts/sandbox/enrichment-agent.d.ts +1 -0
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  263. package/dist/prompts/sandbox/genomic-variant-agent.d.ts +1 -0
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  265. package/dist/prompts/sandbox/immune-profiling-agent.d.ts +1 -0
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  267. package/dist/prompts/sandbox/metabolomics-agent.d.ts +1 -0
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  277. package/dist/prompts/sandbox/pkpd-clinical-response-agent.d.ts +1 -0
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  685. package/dist/tools/workspace/workspace-search.d.ts +25 -0
  686. package/dist/tools/workspace/workspace-search.js +78 -0
  687. package/dist/tools/workspace/write-file.d.ts +16 -0
  688. package/dist/tools/workspace/write-file.js +33 -0
  689. package/dist/workflows/execute-analysis-scheduler.d.ts +94 -0
  690. package/dist/workflows/execute-analysis-scheduler.js +186 -0
  691. package/dist/workflows/execute-analysis.d.ts +271 -0
  692. package/dist/workflows/execute-analysis.js +746 -0
  693. package/dist/workflows/execute-target-assessment.d.ts +101 -0
  694. package/dist/workflows/execute-target-assessment.js +528 -0
  695. package/dist/workflows/metrics.d.ts +37 -0
  696. package/dist/workflows/metrics.js +55 -0
  697. package/dist/workflows/plan/level.d.ts +12 -0
  698. package/dist/workflows/plan/level.js +12 -0
  699. package/dist/workflows/register-workflows.d.ts +51 -0
  700. package/dist/workflows/register-workflows.js +48 -0
  701. package/dist/workflows/resume-execute-analysis.d.ts +70 -0
  702. package/dist/workflows/resume-execute-analysis.js +80 -0
  703. package/dist/workflows/sandbox-step.d.ts +243 -0
  704. package/dist/workflows/sandbox-step.js +573 -0
  705. package/dist/workflows/target-assessment/assemblers/index.d.ts +5 -0
  706. package/dist/workflows/target-assessment/assemblers/index.js +4 -0
  707. package/dist/workflows/target-assessment/assemblers/literature.d.ts +299 -0
  708. package/dist/workflows/target-assessment/assemblers/literature.js +987 -0
  709. package/dist/workflows/target-assessment/assemblers/orchestrator.d.ts +109 -0
  710. package/dist/workflows/target-assessment/assemblers/orchestrator.js +835 -0
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  712. package/dist/workflows/target-assessment/assemblers/safety.js +985 -0
  713. package/dist/workflows/target-assessment/assemblers/trials.d.ts +30 -0
  714. package/dist/workflows/target-assessment/assemblers/trials.js +75 -0
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  716. package/dist/workflows/target-assessment/collectors/index.js +468 -0
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  722. package/dist/workflows/target-assessment/decisions/index.js +127 -0
  723. package/dist/workflows/target-assessment/fanout/index.d.ts +31 -0
  724. package/dist/workflows/target-assessment/fanout/index.js +155 -0
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  726. package/dist/workflows/target-assessment/lib/approval-precedents.js +119 -0
  727. package/dist/workflows/target-assessment/lib/citation-validator.d.ts +46 -0
  728. package/dist/workflows/target-assessment/lib/citation-validator.js +316 -0
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  730. package/dist/workflows/target-assessment/lib/clinical-consequence-annotator.js +172 -0
  731. package/dist/workflows/target-assessment/lib/clinical-evidence-attribution.d.ts +45 -0
  732. package/dist/workflows/target-assessment/lib/clinical-evidence-attribution.js +156 -0
  733. package/dist/workflows/target-assessment/lib/compute-derived.d.ts +19 -0
  734. package/dist/workflows/target-assessment/lib/compute-derived.js +252 -0
  735. package/dist/workflows/target-assessment/lib/compute-selectivity.d.ts +15 -0
  736. package/dist/workflows/target-assessment/lib/compute-selectivity.js +18 -0
  737. package/dist/workflows/target-assessment/lib/dedup-modulators.d.ts +37 -0
  738. package/dist/workflows/target-assessment/lib/dedup-modulators.js +157 -0
  739. package/dist/workflows/target-assessment/lib/evidence-conflict-detector.d.ts +17 -0
  740. package/dist/workflows/target-assessment/lib/evidence-conflict-detector.js +100 -0
  741. package/dist/workflows/target-assessment/lib/expression-constants.d.ts +21 -0
  742. package/dist/workflows/target-assessment/lib/expression-constants.js +21 -0
  743. package/dist/workflows/target-assessment/lib/family-complex-supplement.d.ts +21 -0
  744. package/dist/workflows/target-assessment/lib/family-complex-supplement.js +37 -0
  745. package/dist/workflows/target-assessment/lib/heterodimer-filter.d.ts +39 -0
  746. package/dist/workflows/target-assessment/lib/heterodimer-filter.js +54 -0
  747. package/dist/workflows/target-assessment/lib/intended-polypharm-filter.d.ts +4 -0
  748. package/dist/workflows/target-assessment/lib/intended-polypharm-filter.js +24 -0
  749. package/dist/workflows/target-assessment/lib/llm-step.d.ts +77 -0
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  752. package/dist/workflows/target-assessment/lib/meddra-organ-map.js +126 -0
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  755. package/dist/workflows/target-assessment/lib/recommendation-sanitizer.d.ts +2 -0
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  757. package/dist/workflows/target-assessment/lib/regulatory-actions.d.ts +26 -0
  758. package/dist/workflows/target-assessment/lib/regulatory-actions.js +147 -0
  759. package/dist/workflows/target-assessment/lib/structured-llm.d.ts +58 -0
  760. package/dist/workflows/target-assessment/lib/structured-llm.js +101 -0
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  762. package/dist/workflows/target-assessment/lib/target-identity-filter.js +86 -0
  763. package/dist/workflows/target-assessment/lib/therapeutic-programs.d.ts +20 -0
  764. package/dist/workflows/target-assessment/lib/therapeutic-programs.js +68 -0
  765. package/dist/workflows/target-assessment/metrics.d.ts +21 -0
  766. package/dist/workflows/target-assessment/metrics.js +42 -0
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  768. package/dist/workflows/target-assessment/phase4-assemble.js +39 -0
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  770. package/dist/workflows/target-assessment/phase5-persist.js +461 -0
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  772. package/dist/workflows/target-assessment/progress.js +76 -0
  773. package/dist/workflows/target-assessment/schemas.d.ts +931 -0
  774. package/dist/workflows/target-assessment/schemas.js +293 -0
  775. package/dist/workflows/target-assessment/steps/collectors/pathways.d.ts +15 -0
  776. package/dist/workflows/target-assessment/steps/collectors/pathways.js +58 -0
  777. package/dist/workflows/target-assessment/steps/fanout/aes-for-one-class-drug-step.d.ts +34 -0
  778. package/dist/workflows/target-assessment/steps/fanout/aes-for-one-class-drug-step.js +31 -0
  779. package/dist/workflows/target-assessment/steps/fanout/aes-for-one-trial-step.d.ts +57 -0
  780. package/dist/workflows/target-assessment/steps/fanout/aes-for-one-trial-step.js +54 -0
  781. package/dist/workflows/target-assessment/steps/fanout/faers-for-one-modulator-step.d.ts +35 -0
  782. package/dist/workflows/target-assessment/steps/fanout/faers-for-one-modulator-step.js +32 -0
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  784. package/dist/workflows/target-assessment/steps/fanout/index.js +10 -0
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  792. package/dist/workflows/target-assessment/steps/phase2-aggregate.js +38 -0
  793. package/dist/workflows/target-assessment/steps/phase3-aggregate.d.ts +936 -0
  794. package/dist/workflows/target-assessment/steps/phase3-aggregate.js +22 -0
  795. package/dist/workflows/target-assessment/steps/synthesis/diagnostics.d.ts +34 -0
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  798. package/dist/workflows/target-assessment/sub-workflows/index.js +11 -0
  799. package/dist/workflows/target-assessment/sub-workflows/per-class-drug-aes.d.ts +41 -0
  800. package/dist/workflows/target-assessment/sub-workflows/per-class-drug-aes.js +12 -0
  801. package/dist/workflows/target-assessment/sub-workflows/per-modulator-faers.d.ts +41 -0
  802. package/dist/workflows/target-assessment/sub-workflows/per-modulator-faers.js +12 -0
  803. package/dist/workflows/target-assessment/sub-workflows/per-modulator-polypharm.d.ts +36 -0
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  806. package/dist/workflows/target-assessment/sub-workflows/per-trial-aes.js +12 -0
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  812. package/dist/workspace/filesystem.js +304 -0
  813. package/dist/workspace/mount-strategy.d.ts +50 -0
  814. package/dist/workspace/mount-strategy.js +67 -0
  815. package/dist/workspace/paths.d.ts +185 -0
  816. package/dist/workspace/paths.js +219 -0
  817. package/dist/workspace/provenance-collector.d.ts +34 -0
  818. package/dist/workspace/provenance-collector.js +16 -0
  819. package/dist/workspace/search-config.d.ts +23 -0
  820. package/dist/workspace/search-config.js +43 -0
  821. package/dist/workspace/workspace-paths.d.ts +26 -0
  822. package/dist/workspace/workspace-paths.js +31 -0
  823. package/package.json +101 -0
package/dist/workflows/target-assessment/steps/phase1-aggregate.d.ts ADDED
@@ -0,0 +1,1018 @@
1
+ /**
2
+ * Phase 1 aggregator — schema definitions retained for downstream
3
+ * type-checking. The DBOS workflow assembles the Phase-1 bundle inline.
4
+ */
5
+ import { z } from "zod";
6
+ export declare const Phase1AggregateInputSchema: z.ZodObject<{
7
+ "collector-opentargets": z.ZodDiscriminatedUnion<[z.ZodObject<{
8
+ coverage: z.ZodLiteral<"available">;
9
+ data: z.ZodObject<{
10
+ ensemblId: z.ZodString;
11
+ approvedSymbol: z.ZodString;
12
+ approvedName: z.ZodString;
13
+ tractability: z.ZodNullable<z.ZodObject<{
14
+ smallMolecule: z.ZodNullable<z.ZodBoolean>;
15
+ antibody: z.ZodNullable<z.ZodBoolean>;
16
+ otherModalities: z.ZodNullable<z.ZodBoolean>;
17
+ }, z.core.$strip>>;
18
+ associations: z.ZodArray<z.ZodObject<{
19
+ diseaseId: z.ZodString;
20
+ diseaseName: z.ZodString;
21
+ score: z.ZodNumber;
22
+ geneticAssociationScore: z.ZodNullable<z.ZodNumber>;
23
+ knownDrugScore: z.ZodNullable<z.ZodNumber>;
24
+ literatureScore: z.ZodNullable<z.ZodNumber>;
25
+ animalModelScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
26
+ somaticMutationScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
27
+ literaturePmids: z.ZodDefault<z.ZodArray<z.ZodString>>;
28
+ }, z.core.$strip>>;
29
+ safetyLiabilities: z.ZodArray<z.ZodObject<{
30
+ event: z.ZodString;
31
+ biosamples: z.ZodArray<z.ZodString>;
32
+ effects: z.ZodNullable<z.ZodString>;
33
+ source: z.ZodString;
34
+ }, z.core.$strip>>;
35
+ baselineExpression: z.ZodArray<z.ZodObject<{
36
+ tissueId: z.ZodString;
37
+ tissueLabel: z.ZodString;
38
+ organSystem: z.ZodNullable<z.ZodString>;
39
+ rna: z.ZodNullable<z.ZodObject<{
40
+ value: z.ZodNumber;
41
+ unit: z.ZodString;
42
+ }, z.core.$strip>>;
43
+ protein: z.ZodNullable<z.ZodObject<{
44
+ level: z.ZodNullable<z.ZodNumber>;
45
+ }, z.core.$strip>>;
46
+ }, z.core.$strip>>;
47
+ }, z.core.$strip>;
48
+ }, z.core.$strip>, z.ZodObject<{
49
+ coverage: z.ZodLiteral<"queried_no_data">;
50
+ error: z.ZodOptional<z.ZodObject<{
51
+ message: z.ZodString;
52
+ name: z.ZodOptional<z.ZodString>;
53
+ stack: z.ZodOptional<z.ZodString>;
54
+ }, z.core.$strip>>;
55
+ }, z.core.$strip>, z.ZodObject<{
56
+ coverage: z.ZodLiteral<"not_loaded">;
57
+ reason: z.ZodOptional<z.ZodString>;
58
+ }, z.core.$strip>], "coverage">;
59
+ "collector-chembl-modulators": z.ZodDiscriminatedUnion<[z.ZodObject<{
60
+ coverage: z.ZodLiteral<"available">;
61
+ data: z.ZodObject<{
62
+ targetChemblId: z.ZodNullable<z.ZodString>;
63
+ modulators: z.ZodArray<z.ZodObject<{
64
+ moleculeChemblId: z.ZodString;
65
+ parentChemblId: z.ZodNullable<z.ZodString>;
66
+ preferredName: z.ZodNullable<z.ZodString>;
67
+ maxPhase: z.ZodNullable<z.ZodNumber>;
68
+ moleculeType: z.ZodNullable<z.ZodString>;
69
+ firstApproval: z.ZodNullable<z.ZodNumber>;
70
+ evidence_source: z.ZodOptional<z.ZodLiteral<"chembl_activity">>;
71
+ }, z.core.$strip>>;
72
+ }, z.core.$strip>;
73
+ }, z.core.$strip>, z.ZodObject<{
74
+ coverage: z.ZodLiteral<"queried_no_data">;
75
+ error: z.ZodOptional<z.ZodObject<{
76
+ message: z.ZodString;
77
+ name: z.ZodOptional<z.ZodString>;
78
+ stack: z.ZodOptional<z.ZodString>;
79
+ }, z.core.$strip>>;
80
+ }, z.core.$strip>, z.ZodObject<{
81
+ coverage: z.ZodLiteral<"not_loaded">;
82
+ reason: z.ZodOptional<z.ZodString>;
83
+ }, z.core.$strip>], "coverage">;
84
+ "collector-ctgov": z.ZodDiscriminatedUnion<[z.ZodObject<{
85
+ coverage: z.ZodLiteral<"available">;
86
+ data: z.ZodObject<{
87
+ active: z.ZodArray<z.ZodObject<{
88
+ nctId: z.ZodString;
89
+ title: z.ZodString;
90
+ officialTitle: z.ZodNullable<z.ZodString>;
91
+ status: z.ZodString;
92
+ phase: z.ZodNullable<z.ZodString>;
93
+ studyType: z.ZodNullable<z.ZodString>;
94
+ primaryPurpose: z.ZodNullable<z.ZodString>;
95
+ conditions: z.ZodArray<z.ZodString>;
96
+ interventions: z.ZodArray<z.ZodString>;
97
+ interventionDetails: z.ZodArray<z.ZodObject<{
98
+ name: z.ZodString;
99
+ type: z.ZodNullable<z.ZodString>;
100
+ description: z.ZodNullable<z.ZodString>;
101
+ otherNames: z.ZodArray<z.ZodString>;
102
+ }, z.core.$strip>>;
103
+ enrollmentCount: z.ZodNullable<z.ZodNumber>;
104
+ startDate: z.ZodNullable<z.ZodString>;
105
+ primaryCompletionDate: z.ZodNullable<z.ZodString>;
106
+ whyStopped: z.ZodNullable<z.ZodString>;
107
+ briefSummary: z.ZodNullable<z.ZodString>;
108
+ detailedDescription: z.ZodNullable<z.ZodString>;
109
+ sponsor: z.ZodNullable<z.ZodString>;
110
+ collection_query: z.ZodOptional<z.ZodString>;
111
+ collection_channel: z.ZodOptional<z.ZodEnum<{
112
+ class_modulator: "class_modulator";
113
+ target_symbol: "target_symbol";
114
+ therapeutic_program: "therapeutic_program";
115
+ biomarker_context: "biomarker_context";
116
+ failed_intervention: "failed_intervention";
117
+ }>>;
118
+ }, z.core.$strip>>;
119
+ failed: z.ZodArray<z.ZodObject<{
120
+ nctId: z.ZodString;
121
+ title: z.ZodString;
122
+ officialTitle: z.ZodNullable<z.ZodString>;
123
+ status: z.ZodString;
124
+ phase: z.ZodNullable<z.ZodString>;
125
+ studyType: z.ZodNullable<z.ZodString>;
126
+ primaryPurpose: z.ZodNullable<z.ZodString>;
127
+ conditions: z.ZodArray<z.ZodString>;
128
+ interventions: z.ZodArray<z.ZodString>;
129
+ interventionDetails: z.ZodArray<z.ZodObject<{
130
+ name: z.ZodString;
131
+ type: z.ZodNullable<z.ZodString>;
132
+ description: z.ZodNullable<z.ZodString>;
133
+ otherNames: z.ZodArray<z.ZodString>;
134
+ }, z.core.$strip>>;
135
+ enrollmentCount: z.ZodNullable<z.ZodNumber>;
136
+ startDate: z.ZodNullable<z.ZodString>;
137
+ primaryCompletionDate: z.ZodNullable<z.ZodString>;
138
+ whyStopped: z.ZodNullable<z.ZodString>;
139
+ briefSummary: z.ZodNullable<z.ZodString>;
140
+ detailedDescription: z.ZodNullable<z.ZodString>;
141
+ sponsor: z.ZodNullable<z.ZodString>;
142
+ collection_query: z.ZodOptional<z.ZodString>;
143
+ collection_channel: z.ZodOptional<z.ZodEnum<{
144
+ class_modulator: "class_modulator";
145
+ target_symbol: "target_symbol";
146
+ therapeutic_program: "therapeutic_program";
147
+ biomarker_context: "biomarker_context";
148
+ failed_intervention: "failed_intervention";
149
+ }>>;
150
+ }, z.core.$strip>>;
151
+ }, z.core.$strip>;
152
+ }, z.core.$strip>, z.ZodObject<{
153
+ coverage: z.ZodLiteral<"queried_no_data">;
154
+ error: z.ZodOptional<z.ZodObject<{
155
+ message: z.ZodString;
156
+ name: z.ZodOptional<z.ZodString>;
157
+ stack: z.ZodOptional<z.ZodString>;
158
+ }, z.core.$strip>>;
159
+ }, z.core.$strip>, z.ZodObject<{
160
+ coverage: z.ZodLiteral<"not_loaded">;
161
+ reason: z.ZodOptional<z.ZodString>;
162
+ }, z.core.$strip>], "coverage">;
163
+ "collector-faers-by-target": z.ZodDiscriminatedUnion<[z.ZodObject<{
164
+ coverage: z.ZodLiteral<"available">;
165
+ data: z.ZodObject<{
166
+ drugProbed: z.ZodString;
167
+ totalReports: z.ZodNullable<z.ZodNumber>;
168
+ topReactions: z.ZodArray<z.ZodObject<{
169
+ reaction: z.ZodString;
170
+ count: z.ZodNumber;
171
+ }, z.core.$strip>>;
172
+ seriousness: z.ZodNullable<z.ZodObject<{
173
+ totalReports: z.ZodNumber;
174
+ fatalCount: z.ZodNumber;
175
+ hospitalizationCount: z.ZodNumber;
176
+ lifeThreateningCount: z.ZodNumber;
177
+ disablingCount: z.ZodNumber;
178
+ congenitalAnomalyCount: z.ZodDefault<z.ZodNumber>;
179
+ otherSeriousCount: z.ZodDefault<z.ZodNumber>;
180
+ }, z.core.$strip>>;
181
+ }, z.core.$strip>;
182
+ }, z.core.$strip>, z.ZodObject<{
183
+ coverage: z.ZodLiteral<"queried_no_data">;
184
+ error: z.ZodOptional<z.ZodObject<{
185
+ message: z.ZodString;
186
+ name: z.ZodOptional<z.ZodString>;
187
+ stack: z.ZodOptional<z.ZodString>;
188
+ }, z.core.$strip>>;
189
+ }, z.core.$strip>, z.ZodObject<{
190
+ coverage: z.ZodLiteral<"not_loaded">;
191
+ reason: z.ZodOptional<z.ZodString>;
192
+ }, z.core.$strip>], "coverage">;
193
+ "collector-expression-human": z.ZodDiscriminatedUnion<[z.ZodObject<{
194
+ coverage: z.ZodLiteral<"available">;
195
+ data: z.ZodObject<{
196
+ source: z.ZodEnum<{
197
+ gtex: "gtex";
198
+ hpa_consensus: "hpa_consensus";
199
+ hpa_rna_tissue: "hpa_rna_tissue";
200
+ }>;
201
+ unit: z.ZodEnum<{
202
+ tpm: "tpm";
203
+ ntpm: "ntpm";
204
+ consensus_normalized: "consensus_normalized";
205
+ }>;
206
+ normalization_notes: z.ZodString;
207
+ tissues: z.ZodArray<z.ZodObject<{
208
+ tissueLabel: z.ZodString;
209
+ organSystem: z.ZodNullable<z.ZodString>;
210
+ value: z.ZodNullable<z.ZodNumber>;
211
+ protein: z.ZodNullable<z.ZodNumber>;
212
+ }, z.core.$strip>>;
213
+ }, z.core.$strip>;
214
+ }, z.core.$strip>, z.ZodObject<{
215
+ coverage: z.ZodLiteral<"queried_no_data">;
216
+ error: z.ZodOptional<z.ZodObject<{
217
+ message: z.ZodString;
218
+ name: z.ZodOptional<z.ZodString>;
219
+ stack: z.ZodOptional<z.ZodString>;
220
+ }, z.core.$strip>>;
221
+ }, z.core.$strip>, z.ZodObject<{
222
+ coverage: z.ZodLiteral<"not_loaded">;
223
+ reason: z.ZodOptional<z.ZodString>;
224
+ }, z.core.$strip>], "coverage">;
225
+ "collector-expression-multi-species": z.ZodDiscriminatedUnion<[z.ZodObject<{
226
+ coverage: z.ZodLiteral<"available">;
227
+ data: z.ZodObject<{
228
+ geneSymbol: z.ZodString;
229
+ humanEnsemblId: z.ZodNullable<z.ZodString>;
230
+ bySpecies: z.ZodArray<z.ZodObject<{
231
+ species: z.ZodString;
232
+ taxonId: z.ZodNumber;
233
+ ensemblId: z.ZodString;
234
+ source: z.ZodString;
235
+ unit: z.ZodString;
236
+ normalization_notes: z.ZodString;
237
+ tissues: z.ZodArray<z.ZodObject<{
238
+ tissue: z.ZodString;
239
+ rank: z.ZodEnum<{
240
+ high: "high";
241
+ medium: "medium";
242
+ low: "low";
243
+ absent: "absent";
244
+ }>;
245
+ expressionScore: z.ZodNullable<z.ZodNumber>;
246
+ }, z.core.$strip>>;
247
+ }, z.core.$strip>>;
248
+ notFound: z.ZodArray<z.ZodString>;
249
+ }, z.core.$strip>;
250
+ }, z.core.$strip>, z.ZodObject<{
251
+ coverage: z.ZodLiteral<"queried_no_data">;
252
+ error: z.ZodOptional<z.ZodObject<{
253
+ message: z.ZodString;
254
+ name: z.ZodOptional<z.ZodString>;
255
+ stack: z.ZodOptional<z.ZodString>;
256
+ }, z.core.$strip>>;
257
+ }, z.core.$strip>, z.ZodObject<{
258
+ coverage: z.ZodLiteral<"not_loaded">;
259
+ reason: z.ZodOptional<z.ZodString>;
260
+ }, z.core.$strip>], "coverage">;
261
+ "collector-clinvar": z.ZodDiscriminatedUnion<[z.ZodObject<{
262
+ coverage: z.ZodLiteral<"available">;
263
+ data: z.ZodObject<{
264
+ totalFound: z.ZodNumber;
265
+ variants: z.ZodArray<z.ZodObject<{
266
+ variationId: z.ZodString;
267
+ title: z.ZodString;
268
+ clinicalSignificance: z.ZodString;
269
+ reviewStatus: z.ZodString;
270
+ conditions: z.ZodArray<z.ZodString>;
271
+ molecularConsequence: z.ZodString;
272
+ accession: z.ZodString;
273
+ }, z.core.$strip>>;
274
+ }, z.core.$strip>;
275
+ }, z.core.$strip>, z.ZodObject<{
276
+ coverage: z.ZodLiteral<"queried_no_data">;
277
+ error: z.ZodOptional<z.ZodObject<{
278
+ message: z.ZodString;
279
+ name: z.ZodOptional<z.ZodString>;
280
+ stack: z.ZodOptional<z.ZodString>;
281
+ }, z.core.$strip>>;
282
+ }, z.core.$strip>, z.ZodObject<{
283
+ coverage: z.ZodLiteral<"not_loaded">;
284
+ reason: z.ZodOptional<z.ZodString>;
285
+ }, z.core.$strip>], "coverage">;
286
+ "collector-cbioportal": z.ZodDiscriminatedUnion<[z.ZodObject<{
287
+ coverage: z.ZodLiteral<"available">;
288
+ data: z.ZodObject<{
289
+ entrezGeneId: z.ZodNullable<z.ZodNumber>;
290
+ rows: z.ZodArray<z.ZodObject<{
291
+ cancerTypeId: z.ZodString;
292
+ cancerTypeName: z.ZodString;
293
+ totalSamples: z.ZodNumber;
294
+ mutatedSamples: z.ZodNumber;
295
+ frequency: z.ZodNumber;
296
+ studies: z.ZodArray<z.ZodString>;
297
+ }, z.core.$strip>>;
298
+ }, z.core.$strip>;
299
+ }, z.core.$strip>, z.ZodObject<{
300
+ coverage: z.ZodLiteral<"queried_no_data">;
301
+ error: z.ZodOptional<z.ZodObject<{
302
+ message: z.ZodString;
303
+ name: z.ZodOptional<z.ZodString>;
304
+ stack: z.ZodOptional<z.ZodString>;
305
+ }, z.core.$strip>>;
306
+ }, z.core.$strip>, z.ZodObject<{
307
+ coverage: z.ZodLiteral<"not_loaded">;
308
+ reason: z.ZodOptional<z.ZodString>;
309
+ }, z.core.$strip>], "coverage">;
310
+ "collector-impc": z.ZodDiscriminatedUnion<[z.ZodObject<{
311
+ coverage: z.ZodLiteral<"available">;
312
+ data: z.ZodObject<{
313
+ mouseMarkerSymbol: z.ZodNullable<z.ZodString>;
314
+ mgiAccessionId: z.ZodNullable<z.ZodString>;
315
+ viability: z.ZodNullable<z.ZodEnum<{
316
+ lethal_pre_weaning: "lethal_pre_weaning";
317
+ subviable: "subviable";
318
+ viable: "viable";
319
+ }>>;
320
+ viabilityCalls: z.ZodArray<z.ZodObject<{
321
+ zygosity: z.ZodString;
322
+ parameterStableId: z.ZodString;
323
+ mpTerm: z.ZodNullable<z.ZodObject<{
324
+ id: z.ZodString;
325
+ name: z.ZodString;
326
+ }, z.core.$strip>>;
327
+ }, z.core.$strip>>;
328
+ mpTerms: z.ZodArray<z.ZodObject<{
329
+ id: z.ZodString;
330
+ term: z.ZodString;
331
+ bestPValue: z.ZodNullable<z.ZodNumber>;
332
+ }, z.core.$strip>>;
333
+ organSystems: z.ZodArray<z.ZodString>;
334
+ sexDimorphic: z.ZodBoolean;
335
+ phenotypeCount: z.ZodNumber;
336
+ }, z.core.$strip>;
337
+ }, z.core.$strip>, z.ZodObject<{
338
+ coverage: z.ZodLiteral<"queried_no_data">;
339
+ error: z.ZodOptional<z.ZodObject<{
340
+ message: z.ZodString;
341
+ name: z.ZodOptional<z.ZodString>;
342
+ stack: z.ZodOptional<z.ZodString>;
343
+ }, z.core.$strip>>;
344
+ }, z.core.$strip>, z.ZodObject<{
345
+ coverage: z.ZodLiteral<"not_loaded">;
346
+ reason: z.ZodOptional<z.ZodString>;
347
+ }, z.core.$strip>], "coverage">;
348
+ "collector-pubmed-index": z.ZodDiscriminatedUnion<[z.ZodObject<{
349
+ coverage: z.ZodLiteral<"available">;
350
+ data: z.ZodObject<{
351
+ totalFound: z.ZodNumber;
352
+ topPmids: z.ZodArray<z.ZodString>;
353
+ results: z.ZodArray<z.ZodObject<{
354
+ pmid: z.ZodString;
355
+ title: z.ZodString;
356
+ journal: z.ZodString;
357
+ year: z.ZodString;
358
+ authors: z.ZodString;
359
+ }, z.core.$strip>>;
360
+ }, z.core.$strip>;
361
+ }, z.core.$strip>, z.ZodObject<{
362
+ coverage: z.ZodLiteral<"queried_no_data">;
363
+ error: z.ZodOptional<z.ZodObject<{
364
+ message: z.ZodString;
365
+ name: z.ZodOptional<z.ZodString>;
366
+ stack: z.ZodOptional<z.ZodString>;
367
+ }, z.core.$strip>>;
368
+ }, z.core.$strip>, z.ZodObject<{
369
+ coverage: z.ZodLiteral<"not_loaded">;
370
+ reason: z.ZodOptional<z.ZodString>;
371
+ }, z.core.$strip>], "coverage">;
372
+ "collector-pathways": z.ZodDiscriminatedUnion<[z.ZodObject<{
373
+ coverage: z.ZodLiteral<"available">;
374
+ data: z.ZodObject<{
375
+ pathways: z.ZodArray<z.ZodObject<{
376
+ id: z.ZodString;
377
+ name: z.ZodString;
378
+ source: z.ZodEnum<{
379
+ kegg: "kegg";
380
+ reactome: "reactome";
381
+ }>;
382
+ url: z.ZodOptional<z.ZodString>;
383
+ entity_uniprots: z.ZodOptional<z.ZodArray<z.ZodString>>;
384
+ metadata: z.ZodOptional<z.ZodObject<{
385
+ species_present: z.ZodOptional<z.ZodArray<z.ZodString>>;
386
+ }, z.core.$strip>>;
387
+ }, z.core.$strip>>;
388
+ }, z.core.$strip>;
389
+ }, z.core.$strip>, z.ZodObject<{
390
+ coverage: z.ZodLiteral<"queried_no_data">;
391
+ error: z.ZodOptional<z.ZodObject<{
392
+ message: z.ZodString;
393
+ name: z.ZodOptional<z.ZodString>;
394
+ stack: z.ZodOptional<z.ZodString>;
395
+ }, z.core.$strip>>;
396
+ }, z.core.$strip>, z.ZodObject<{
397
+ coverage: z.ZodLiteral<"not_loaded">;
398
+ reason: z.ZodOptional<z.ZodString>;
399
+ }, z.core.$strip>], "coverage">;
400
+ "collector-string-ppi": z.ZodDiscriminatedUnion<[z.ZodObject<{
401
+ coverage: z.ZodLiteral<"available">;
402
+ data: z.ZodObject<{
403
+ partners: z.ZodArray<z.ZodObject<{
404
+ proteinA: z.ZodString;
405
+ proteinB: z.ZodString;
406
+ score: z.ZodNumber;
407
+ experimentalScore: z.ZodOptional<z.ZodNumber>;
408
+ databaseScore: z.ZodOptional<z.ZodNumber>;
409
+ textminingScore: z.ZodOptional<z.ZodNumber>;
410
+ }, z.core.$strip>>;
411
+ }, z.core.$strip>;
412
+ }, z.core.$strip>, z.ZodObject<{
413
+ coverage: z.ZodLiteral<"queried_no_data">;
414
+ error: z.ZodOptional<z.ZodObject<{
415
+ message: z.ZodString;
416
+ name: z.ZodOptional<z.ZodString>;
417
+ stack: z.ZodOptional<z.ZodString>;
418
+ }, z.core.$strip>>;
419
+ }, z.core.$strip>, z.ZodObject<{
420
+ coverage: z.ZodLiteral<"not_loaded">;
421
+ reason: z.ZodOptional<z.ZodString>;
422
+ }, z.core.$strip>], "coverage">;
423
+ "collector-family-complexes": z.ZodDiscriminatedUnion<[z.ZodObject<{
424
+ coverage: z.ZodLiteral<"available">;
425
+ data: z.ZodObject<{
426
+ primaryTargetGene: z.ZodString;
427
+ primaryTargetUniprot: z.ZodNullable<z.ZodString>;
428
+ accessoryProteinNames: z.ZodArray<z.ZodString>;
429
+ complexes: z.ZodArray<z.ZodObject<{
430
+ complexName: z.ZodString;
431
+ complexId: z.ZodNullable<z.ZodNumber>;
432
+ accessoryNames: z.ZodArray<z.ZodString>;
433
+ subunitNames: z.ZodArray<z.ZodString>;
434
+ }, z.core.$strip>>;
435
+ }, z.core.$strip>;
436
+ }, z.core.$strip>, z.ZodObject<{
437
+ coverage: z.ZodLiteral<"queried_no_data">;
438
+ error: z.ZodOptional<z.ZodObject<{
439
+ message: z.ZodString;
440
+ name: z.ZodOptional<z.ZodString>;
441
+ stack: z.ZodOptional<z.ZodString>;
442
+ }, z.core.$strip>>;
443
+ }, z.core.$strip>, z.ZodObject<{
444
+ coverage: z.ZodLiteral<"not_loaded">;
445
+ reason: z.ZodOptional<z.ZodString>;
446
+ }, z.core.$strip>], "coverage">;
447
+ "collector-therapeutic-programs": z.ZodDiscriminatedUnion<[z.ZodObject<{
448
+ coverage: z.ZodLiteral<"available">;
449
+ data: z.ZodObject<{
450
+ programs: z.ZodArray<z.ZodObject<{
451
+ programId: z.ZodString;
452
+ name: z.ZodString;
453
+ targetSymbol: z.ZodString;
454
+ targetUniprot: z.ZodNullable<z.ZodString>;
455
+ modality: z.ZodString;
456
+ sponsor: z.ZodNullable<z.ZodString>;
457
+ mechanism: z.ZodString;
458
+ status: z.ZodString;
459
+ nctIds: z.ZodArray<z.ZodString>;
460
+ pmids: z.ZodArray<z.ZodString>;
461
+ evidence: z.ZodArray<z.ZodObject<{
462
+ pmid: z.ZodOptional<z.ZodString>;
463
+ doi: z.ZodOptional<z.ZodString>;
464
+ source: z.ZodString;
465
+ predicate: z.ZodOptional<z.ZodString>;
466
+ score: z.ZodOptional<z.ZodNumber>;
467
+ strength: z.ZodOptional<z.ZodString>;
468
+ is_human: z.ZodOptional<z.ZodBoolean>;
469
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
470
+ excerpt: z.ZodOptional<z.ZodString>;
471
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
472
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
473
+ document: z.ZodString;
474
+ section: z.ZodOptional<z.ZodString>;
475
+ doc_id: z.ZodOptional<z.ZodString>;
476
+ doc_url: z.ZodOptional<z.ZodString>;
477
+ }, z.core.$strip>>;
478
+ }, z.core.$strip>>;
479
+ confidence: z.ZodEnum<{
480
+ high: "high";
481
+ medium: "medium";
482
+ low: "low";
483
+ }>;
484
+ }, z.core.$strip>>;
485
+ }, z.core.$strip>;
486
+ }, z.core.$strip>, z.ZodObject<{
487
+ coverage: z.ZodLiteral<"queried_no_data">;
488
+ error: z.ZodOptional<z.ZodObject<{
489
+ message: z.ZodString;
490
+ name: z.ZodOptional<z.ZodString>;
491
+ stack: z.ZodOptional<z.ZodString>;
492
+ }, z.core.$strip>>;
493
+ }, z.core.$strip>, z.ZodObject<{
494
+ coverage: z.ZodLiteral<"not_loaded">;
495
+ reason: z.ZodOptional<z.ZodString>;
496
+ }, z.core.$strip>], "coverage">;
497
+ }, z.core.$strip>;
498
+ export declare const phase1OutputSchema: z.ZodObject<{
499
+ resolved: z.ZodObject<{
500
+ assessmentId: z.ZodString;
501
+ goal: z.ZodNullable<z.ZodString>;
502
+ canonicalId: z.ZodString;
503
+ canonicalOntology: z.ZodEnum<{
504
+ ensembl: "ensembl";
505
+ hgnc: "hgnc";
506
+ }>;
507
+ geneSymbol: z.ZodString;
508
+ approvedName: z.ZodString;
509
+ ids: z.ZodObject<{
510
+ hgnc: z.ZodNullable<z.ZodString>;
511
+ ensembl: z.ZodNullable<z.ZodString>;
512
+ uniprot: z.ZodNullable<z.ZodString>;
513
+ chembl: z.ZodNullable<z.ZodString>;
514
+ entrez: z.ZodNullable<z.ZodString>;
515
+ }, z.core.$strip>;
516
+ synonyms: z.ZodArray<z.ZodString>;
517
+ proteinSynonyms: z.ZodArray<z.ZodString>;
518
+ proteinFamily: z.ZodNullable<z.ZodString>;
519
+ resolutionCoverage: z.ZodObject<{
520
+ hgnc: z.ZodBoolean;
521
+ uniprot: z.ZodBoolean;
522
+ ensembl: z.ZodBoolean;
523
+ chembl: z.ZodBoolean;
524
+ }, z.core.$strip>;
525
+ }, z.core.$strip>;
526
+ collectors: z.ZodObject<{
527
+ opentargets: z.ZodDiscriminatedUnion<[z.ZodObject<{
528
+ coverage: z.ZodLiteral<"available">;
529
+ data: z.ZodObject<{
530
+ ensemblId: z.ZodString;
531
+ approvedSymbol: z.ZodString;
532
+ approvedName: z.ZodString;
533
+ tractability: z.ZodNullable<z.ZodObject<{
534
+ smallMolecule: z.ZodNullable<z.ZodBoolean>;
535
+ antibody: z.ZodNullable<z.ZodBoolean>;
536
+ otherModalities: z.ZodNullable<z.ZodBoolean>;
537
+ }, z.core.$strip>>;
538
+ associations: z.ZodArray<z.ZodObject<{
539
+ diseaseId: z.ZodString;
540
+ diseaseName: z.ZodString;
541
+ score: z.ZodNumber;
542
+ geneticAssociationScore: z.ZodNullable<z.ZodNumber>;
543
+ knownDrugScore: z.ZodNullable<z.ZodNumber>;
544
+ literatureScore: z.ZodNullable<z.ZodNumber>;
545
+ animalModelScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
546
+ somaticMutationScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
547
+ literaturePmids: z.ZodDefault<z.ZodArray<z.ZodString>>;
548
+ }, z.core.$strip>>;
549
+ safetyLiabilities: z.ZodArray<z.ZodObject<{
550
+ event: z.ZodString;
551
+ biosamples: z.ZodArray<z.ZodString>;
552
+ effects: z.ZodNullable<z.ZodString>;
553
+ source: z.ZodString;
554
+ }, z.core.$strip>>;
555
+ baselineExpression: z.ZodArray<z.ZodObject<{
556
+ tissueId: z.ZodString;
557
+ tissueLabel: z.ZodString;
558
+ organSystem: z.ZodNullable<z.ZodString>;
559
+ rna: z.ZodNullable<z.ZodObject<{
560
+ value: z.ZodNumber;
561
+ unit: z.ZodString;
562
+ }, z.core.$strip>>;
563
+ protein: z.ZodNullable<z.ZodObject<{
564
+ level: z.ZodNullable<z.ZodNumber>;
565
+ }, z.core.$strip>>;
566
+ }, z.core.$strip>>;
567
+ }, z.core.$strip>;
568
+ }, z.core.$strip>, z.ZodObject<{
569
+ coverage: z.ZodLiteral<"queried_no_data">;
570
+ error: z.ZodOptional<z.ZodObject<{
571
+ message: z.ZodString;
572
+ name: z.ZodOptional<z.ZodString>;
573
+ stack: z.ZodOptional<z.ZodString>;
574
+ }, z.core.$strip>>;
575
+ }, z.core.$strip>, z.ZodObject<{
576
+ coverage: z.ZodLiteral<"not_loaded">;
577
+ reason: z.ZodOptional<z.ZodString>;
578
+ }, z.core.$strip>], "coverage">;
579
+ chemblModulators: z.ZodDiscriminatedUnion<[z.ZodObject<{
580
+ coverage: z.ZodLiteral<"available">;
581
+ data: z.ZodObject<{
582
+ targetChemblId: z.ZodNullable<z.ZodString>;
583
+ modulators: z.ZodArray<z.ZodObject<{
584
+ moleculeChemblId: z.ZodString;
585
+ parentChemblId: z.ZodNullable<z.ZodString>;
586
+ preferredName: z.ZodNullable<z.ZodString>;
587
+ maxPhase: z.ZodNullable<z.ZodNumber>;
588
+ moleculeType: z.ZodNullable<z.ZodString>;
589
+ firstApproval: z.ZodNullable<z.ZodNumber>;
590
+ evidence_source: z.ZodOptional<z.ZodLiteral<"chembl_activity">>;
591
+ }, z.core.$strip>>;
592
+ }, z.core.$strip>;
593
+ }, z.core.$strip>, z.ZodObject<{
594
+ coverage: z.ZodLiteral<"queried_no_data">;
595
+ error: z.ZodOptional<z.ZodObject<{
596
+ message: z.ZodString;
597
+ name: z.ZodOptional<z.ZodString>;
598
+ stack: z.ZodOptional<z.ZodString>;
599
+ }, z.core.$strip>>;
600
+ }, z.core.$strip>, z.ZodObject<{
601
+ coverage: z.ZodLiteral<"not_loaded">;
602
+ reason: z.ZodOptional<z.ZodString>;
603
+ }, z.core.$strip>], "coverage">;
604
+ ctgov: z.ZodDiscriminatedUnion<[z.ZodObject<{
605
+ coverage: z.ZodLiteral<"available">;
606
+ data: z.ZodObject<{
607
+ active: z.ZodArray<z.ZodObject<{
608
+ nctId: z.ZodString;
609
+ title: z.ZodString;
610
+ officialTitle: z.ZodNullable<z.ZodString>;
611
+ status: z.ZodString;
612
+ phase: z.ZodNullable<z.ZodString>;
613
+ studyType: z.ZodNullable<z.ZodString>;
614
+ primaryPurpose: z.ZodNullable<z.ZodString>;
615
+ conditions: z.ZodArray<z.ZodString>;
616
+ interventions: z.ZodArray<z.ZodString>;
617
+ interventionDetails: z.ZodArray<z.ZodObject<{
618
+ name: z.ZodString;
619
+ type: z.ZodNullable<z.ZodString>;
620
+ description: z.ZodNullable<z.ZodString>;
621
+ otherNames: z.ZodArray<z.ZodString>;
622
+ }, z.core.$strip>>;
623
+ enrollmentCount: z.ZodNullable<z.ZodNumber>;
624
+ startDate: z.ZodNullable<z.ZodString>;
625
+ primaryCompletionDate: z.ZodNullable<z.ZodString>;
626
+ whyStopped: z.ZodNullable<z.ZodString>;
627
+ briefSummary: z.ZodNullable<z.ZodString>;
628
+ detailedDescription: z.ZodNullable<z.ZodString>;
629
+ sponsor: z.ZodNullable<z.ZodString>;
630
+ collection_query: z.ZodOptional<z.ZodString>;
631
+ collection_channel: z.ZodOptional<z.ZodEnum<{
632
+ class_modulator: "class_modulator";
633
+ target_symbol: "target_symbol";
634
+ therapeutic_program: "therapeutic_program";
635
+ biomarker_context: "biomarker_context";
636
+ failed_intervention: "failed_intervention";
637
+ }>>;
638
+ }, z.core.$strip>>;
639
+ failed: z.ZodArray<z.ZodObject<{
640
+ nctId: z.ZodString;
641
+ title: z.ZodString;
642
+ officialTitle: z.ZodNullable<z.ZodString>;
643
+ status: z.ZodString;
644
+ phase: z.ZodNullable<z.ZodString>;
645
+ studyType: z.ZodNullable<z.ZodString>;
646
+ primaryPurpose: z.ZodNullable<z.ZodString>;
647
+ conditions: z.ZodArray<z.ZodString>;
648
+ interventions: z.ZodArray<z.ZodString>;
649
+ interventionDetails: z.ZodArray<z.ZodObject<{
650
+ name: z.ZodString;
651
+ type: z.ZodNullable<z.ZodString>;
652
+ description: z.ZodNullable<z.ZodString>;
653
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654
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655
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656
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657
+ primaryCompletionDate: z.ZodNullable<z.ZodString>;
658
+ whyStopped: z.ZodNullable<z.ZodString>;
659
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660
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661
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662
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663
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664
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665
+ target_symbol: "target_symbol";
666
+ therapeutic_program: "therapeutic_program";
667
+ biomarker_context: "biomarker_context";
668
+ failed_intervention: "failed_intervention";
669
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670
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671
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672
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673
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674
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675
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676
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677
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678
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679
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680
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681
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682
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683
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684
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685
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686
+ drugProbed: z.ZodString;
687
+ totalReports: z.ZodNullable<z.ZodNumber>;
688
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689
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690
+ count: z.ZodNumber;
691
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692
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693
+ totalReports: z.ZodNumber;
694
+ fatalCount: z.ZodNumber;
695
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696
+ lifeThreateningCount: z.ZodNumber;
697
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698
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699
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700
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701
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702
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703
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704
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705
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706
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707
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708
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709
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710
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711
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712
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713
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714
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715
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716
+ source: z.ZodEnum<{
717
+ gtex: "gtex";
718
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719
+ hpa_rna_tissue: "hpa_rna_tissue";
720
+ }>;
721
+ unit: z.ZodEnum<{
722
+ tpm: "tpm";
723
+ ntpm: "ntpm";
724
+ consensus_normalized: "consensus_normalized";
725
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726
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727
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728
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729
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730
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731
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732
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733
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734
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735
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736
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737
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738
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739
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740
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741
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742
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743
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744
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745
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746
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747
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748
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749
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750
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751
+ species: z.ZodString;
752
+ taxonId: z.ZodNumber;
753
+ ensemblId: z.ZodString;
754
+ source: z.ZodString;
755
+ unit: z.ZodString;
756
+ normalization_notes: z.ZodString;
757
+ tissues: z.ZodArray<z.ZodObject<{
758
+ tissue: z.ZodString;
759
+ rank: z.ZodEnum<{
760
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761
+ medium: "medium";
762
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763
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764
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765
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766
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767
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768
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769
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770
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771
+ coverage: z.ZodLiteral<"queried_no_data">;
772
+ error: z.ZodOptional<z.ZodObject<{
773
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774
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775
+ stack: z.ZodOptional<z.ZodString>;
776
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777
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778
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779
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780
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781
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782
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783
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784
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785
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786
+ variationId: z.ZodString;
787
+ title: z.ZodString;
788
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789
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790
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791
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792
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793
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794
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795
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796
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797
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798
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799
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800
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801
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802
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803
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804
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805
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806
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807
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808
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809
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810
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811
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812
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813
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814
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815
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816
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817
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818
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819
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820
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821
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822
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823
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824
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825
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826
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827
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828
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829
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830
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831
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832
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833
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834
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835
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836
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837
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838
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839
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840
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841
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842
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843
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844
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845
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846
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847
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848
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849
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850
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851
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852
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853
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854
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855
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856
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857
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858
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859
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860
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861
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862
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863
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864
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866
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867
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868
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869
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870
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871
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872
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873
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874
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875
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876
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877
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878
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879
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880
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881
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882
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883
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884
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885
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886
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887
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888
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889
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890
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891
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892
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893
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894
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895
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896
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897
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898
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899
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900
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901
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902
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903
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904
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905
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906
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907
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908
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909
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910
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911
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912
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913
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914
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915
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916
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918
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919
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920
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921
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922
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923
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924
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925
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926
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927
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928
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929
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930
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931
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932
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933
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934
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936
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937
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938
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939
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940
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941
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942
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943
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944
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945
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946
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947
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948
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949
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950
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951
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952
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953
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954
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955
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956
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957
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958
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959
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960
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961
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962
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963
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965
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966
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967
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968
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969
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970
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971
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972
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973
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974
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975
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976
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977
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978
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979
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980
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981
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982
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983
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984
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985
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986
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987
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988
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989
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990
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991
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992
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993
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994
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995
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996
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997
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998
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999
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1000
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1001
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1002
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1003
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1004
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1005
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1006
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1007
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1008
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1009
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1010
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1011
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1012
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1013
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1014
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1015
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1016
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1017
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1018
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