@inflexa-ai/harness 0.1.1

package/dist/workflows/target-assessment/schemas.d.ts

@@ -0,0 +1,931 @@
+/**
+ * Shared schemas for target-assessment workflow inter-step contracts.
+ *
+ * The workflow input/output schemas, the resolved-target shape used by
+ * every Phase-1 collector, and the keyed Phase-1/2/3 bundle shapes.
+ */
+import { z } from "zod";
+export declare const TargetAssessmentInputSchema: z.ZodObject<{
+    assessmentId: z.ZodString;
+    target: z.ZodString;
+    goal: z.ZodOptional<z.ZodNullable<z.ZodString>>;
+    organizationId: z.ZodString;
+    requestedBy: z.ZodString;
+}, z.core.$strip>;
+export type TargetAssessmentInput = z.infer<typeof TargetAssessmentInputSchema>;
+export declare const ResolvedTargetSchema: z.ZodObject<{
+    assessmentId: z.ZodString;
+    goal: z.ZodNullable<z.ZodString>;
+    canonicalId: z.ZodString;
+    canonicalOntology: z.ZodEnum<{
+        ensembl: "ensembl";
+        hgnc: "hgnc";
+    }>;
+    geneSymbol: z.ZodString;
+    approvedName: z.ZodString;
+    ids: z.ZodObject<{
+        hgnc: z.ZodNullable<z.ZodString>;
+        ensembl: z.ZodNullable<z.ZodString>;
+        uniprot: z.ZodNullable<z.ZodString>;
+        chembl: z.ZodNullable<z.ZodString>;
+        entrez: z.ZodNullable<z.ZodString>;
+    }, z.core.$strip>;
+    synonyms: z.ZodArray<z.ZodString>;
+    proteinSynonyms: z.ZodArray<z.ZodString>;
+    proteinFamily: z.ZodNullable<z.ZodString>;
+    resolutionCoverage: z.ZodObject<{
+        hgnc: z.ZodBoolean;
+        uniprot: z.ZodBoolean;
+        ensembl: z.ZodBoolean;
+        chembl: z.ZodBoolean;
+    }, z.core.$strip>;
+}, z.core.$strip>;
+export type ResolvedTarget = z.infer<typeof ResolvedTargetSchema>;
+export declare const OpenTargetsBundleSchema: z.ZodObject<{
+    ensemblId: z.ZodString;
+    approvedSymbol: z.ZodString;
+    approvedName: z.ZodString;
+    tractability: z.ZodNullable<z.ZodObject<{
+        smallMolecule: z.ZodNullable<z.ZodBoolean>;
+        antibody: z.ZodNullable<z.ZodBoolean>;
+        otherModalities: z.ZodNullable<z.ZodBoolean>;
+    }, z.core.$strip>>;
+    associations: z.ZodArray<z.ZodObject<{
+        diseaseId: z.ZodString;
+        diseaseName: z.ZodString;
+        score: z.ZodNumber;
+        geneticAssociationScore: z.ZodNullable<z.ZodNumber>;
+        knownDrugScore: z.ZodNullable<z.ZodNumber>;
+        literatureScore: z.ZodNullable<z.ZodNumber>;
+        animalModelScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
+        somaticMutationScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
+        literaturePmids: z.ZodDefault<z.ZodArray<z.ZodString>>;
+    }, z.core.$strip>>;
+    safetyLiabilities: z.ZodArray<z.ZodObject<{
+        event: z.ZodString;
+        biosamples: z.ZodArray<z.ZodString>;
+        effects: z.ZodNullable<z.ZodString>;
+        source: z.ZodString;
+    }, z.core.$strip>>;
+    baselineExpression: z.ZodArray<z.ZodObject<{
+        tissueId: z.ZodString;
+        tissueLabel: z.ZodString;
+        organSystem: z.ZodNullable<z.ZodString>;
+        rna: z.ZodNullable<z.ZodObject<{
+            value: z.ZodNumber;
+            unit: z.ZodString;
+        }, z.core.$strip>>;
+        protein: z.ZodNullable<z.ZodObject<{
+            level: z.ZodNullable<z.ZodNumber>;
+        }, z.core.$strip>>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type OpenTargetsBundle = z.infer<typeof OpenTargetsBundleSchema>;
+export declare const ChemblModulatorsBundleSchema: z.ZodObject<{
+    targetChemblId: z.ZodNullable<z.ZodString>;
+    modulators: z.ZodArray<z.ZodObject<{
+        moleculeChemblId: z.ZodString;
+        parentChemblId: z.ZodNullable<z.ZodString>;
+        preferredName: z.ZodNullable<z.ZodString>;
+        maxPhase: z.ZodNullable<z.ZodNumber>;
+        moleculeType: z.ZodNullable<z.ZodString>;
+        firstApproval: z.ZodNullable<z.ZodNumber>;
+        evidence_source: z.ZodOptional<z.ZodLiteral<"chembl_activity">>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type ChemblModulatorsBundle = z.infer<typeof ChemblModulatorsBundleSchema>;
+export declare const CtgovInterventionSchema: z.ZodObject<{
+    name: z.ZodString;
+    type: z.ZodNullable<z.ZodString>;
+    description: z.ZodNullable<z.ZodString>;
+    otherNames: z.ZodArray<z.ZodString>;
+}, z.core.$strip>;
+export declare const CtgovTrialSchema: z.ZodObject<{
+    nctId: z.ZodString;
+    title: z.ZodString;
+    officialTitle: z.ZodNullable<z.ZodString>;
+    status: z.ZodString;
+    phase: z.ZodNullable<z.ZodString>;
+    studyType: z.ZodNullable<z.ZodString>;
+    primaryPurpose: z.ZodNullable<z.ZodString>;
+    conditions: z.ZodArray<z.ZodString>;
+    interventions: z.ZodArray<z.ZodString>;
+    interventionDetails: z.ZodArray<z.ZodObject<{
+        name: z.ZodString;
+        type: z.ZodNullable<z.ZodString>;
+        description: z.ZodNullable<z.ZodString>;
+        otherNames: z.ZodArray<z.ZodString>;
+    }, z.core.$strip>>;
+    enrollmentCount: z.ZodNullable<z.ZodNumber>;
+    startDate: z.ZodNullable<z.ZodString>;
+    primaryCompletionDate: z.ZodNullable<z.ZodString>;
+    whyStopped: z.ZodNullable<z.ZodString>;
+    briefSummary: z.ZodNullable<z.ZodString>;
+    detailedDescription: z.ZodNullable<z.ZodString>;
+    sponsor: z.ZodNullable<z.ZodString>;
+    collection_query: z.ZodOptional<z.ZodString>;
+    collection_channel: z.ZodOptional<z.ZodEnum<{
+        class_modulator: "class_modulator";
+        target_symbol: "target_symbol";
+        therapeutic_program: "therapeutic_program";
+        biomarker_context: "biomarker_context";
+        failed_intervention: "failed_intervention";
+    }>>;
+}, z.core.$strip>;
+export declare const CtgovBundleSchema: z.ZodObject<{
+    active: z.ZodArray<z.ZodObject<{
+        nctId: z.ZodString;
+        title: z.ZodString;
+        officialTitle: z.ZodNullable<z.ZodString>;
+        status: z.ZodString;
+        phase: z.ZodNullable<z.ZodString>;
+        studyType: z.ZodNullable<z.ZodString>;
+        primaryPurpose: z.ZodNullable<z.ZodString>;
+        conditions: z.ZodArray<z.ZodString>;
+        interventions: z.ZodArray<z.ZodString>;
+        interventionDetails: z.ZodArray<z.ZodObject<{
+            name: z.ZodString;
+            type: z.ZodNullable<z.ZodString>;
+            description: z.ZodNullable<z.ZodString>;
+            otherNames: z.ZodArray<z.ZodString>;
+        }, z.core.$strip>>;
+        enrollmentCount: z.ZodNullable<z.ZodNumber>;
+        startDate: z.ZodNullable<z.ZodString>;
+        primaryCompletionDate: z.ZodNullable<z.ZodString>;
+        whyStopped: z.ZodNullable<z.ZodString>;
+        briefSummary: z.ZodNullable<z.ZodString>;
+        detailedDescription: z.ZodNullable<z.ZodString>;
+        sponsor: z.ZodNullable<z.ZodString>;
+        collection_query: z.ZodOptional<z.ZodString>;
+        collection_channel: z.ZodOptional<z.ZodEnum<{
+            class_modulator: "class_modulator";
+            target_symbol: "target_symbol";
+            therapeutic_program: "therapeutic_program";
+            biomarker_context: "biomarker_context";
+            failed_intervention: "failed_intervention";
+        }>>;
+    }, z.core.$strip>>;
+    failed: z.ZodArray<z.ZodObject<{
+        nctId: z.ZodString;
+        title: z.ZodString;
+        officialTitle: z.ZodNullable<z.ZodString>;
+        status: z.ZodString;
+        phase: z.ZodNullable<z.ZodString>;
+        studyType: z.ZodNullable<z.ZodString>;
+        primaryPurpose: z.ZodNullable<z.ZodString>;
+        conditions: z.ZodArray<z.ZodString>;
+        interventions: z.ZodArray<z.ZodString>;
+        interventionDetails: z.ZodArray<z.ZodObject<{
+            name: z.ZodString;
+            type: z.ZodNullable<z.ZodString>;
+            description: z.ZodNullable<z.ZodString>;
+            otherNames: z.ZodArray<z.ZodString>;
+        }, z.core.$strip>>;
+        enrollmentCount: z.ZodNullable<z.ZodNumber>;
+        startDate: z.ZodNullable<z.ZodString>;
+        primaryCompletionDate: z.ZodNullable<z.ZodString>;
+        whyStopped: z.ZodNullable<z.ZodString>;
+        briefSummary: z.ZodNullable<z.ZodString>;
+        detailedDescription: z.ZodNullable<z.ZodString>;
+        sponsor: z.ZodNullable<z.ZodString>;
+        collection_query: z.ZodOptional<z.ZodString>;
+        collection_channel: z.ZodOptional<z.ZodEnum<{
+            class_modulator: "class_modulator";
+            target_symbol: "target_symbol";
+            therapeutic_program: "therapeutic_program";
+            biomarker_context: "biomarker_context";
+            failed_intervention: "failed_intervention";
+        }>>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type CtgovBundle = z.infer<typeof CtgovBundleSchema>;
+export declare const FaersByTargetBundleSchema: z.ZodObject<{
+    drugProbed: z.ZodString;
+    totalReports: z.ZodNullable<z.ZodNumber>;
+    topReactions: z.ZodArray<z.ZodObject<{
+        reaction: z.ZodString;
+        count: z.ZodNumber;
+    }, z.core.$strip>>;
+    seriousness: z.ZodNullable<z.ZodObject<{
+        totalReports: z.ZodNumber;
+        fatalCount: z.ZodNumber;
+        hospitalizationCount: z.ZodNumber;
+        lifeThreateningCount: z.ZodNumber;
+        disablingCount: z.ZodNumber;
+        congenitalAnomalyCount: z.ZodDefault<z.ZodNumber>;
+        otherSeriousCount: z.ZodDefault<z.ZodNumber>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type FaersByTargetBundle = z.infer<typeof FaersByTargetBundleSchema>;
+export declare const ExpressionHumanBundleSchema: z.ZodObject<{
+    source: z.ZodEnum<{
+        gtex: "gtex";
+        hpa_consensus: "hpa_consensus";
+        hpa_rna_tissue: "hpa_rna_tissue";
+    }>;
+    unit: z.ZodEnum<{
+        tpm: "tpm";
+        ntpm: "ntpm";
+        consensus_normalized: "consensus_normalized";
+    }>;
+    normalization_notes: z.ZodString;
+    tissues: z.ZodArray<z.ZodObject<{
+        tissueLabel: z.ZodString;
+        organSystem: z.ZodNullable<z.ZodString>;
+        value: z.ZodNullable<z.ZodNumber>;
+        protein: z.ZodNullable<z.ZodNumber>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type ExpressionHumanBundle = z.infer<typeof ExpressionHumanBundleSchema>;
+export declare const ExpressionMultiSpeciesBundleSchema: z.ZodObject<{
+    geneSymbol: z.ZodString;
+    humanEnsemblId: z.ZodNullable<z.ZodString>;
+    bySpecies: z.ZodArray<z.ZodObject<{
+        species: z.ZodString;
+        taxonId: z.ZodNumber;
+        ensemblId: z.ZodString;
+        source: z.ZodString;
+        unit: z.ZodString;
+        normalization_notes: z.ZodString;
+        tissues: z.ZodArray<z.ZodObject<{
+            tissue: z.ZodString;
+            rank: z.ZodEnum<{
+                high: "high";
+                medium: "medium";
+                low: "low";
+                absent: "absent";
+            }>;
+            expressionScore: z.ZodNullable<z.ZodNumber>;
+        }, z.core.$strip>>;
+    }, z.core.$strip>>;
+    notFound: z.ZodArray<z.ZodString>;
+}, z.core.$strip>;
+export type ExpressionMultiSpeciesBundle = z.infer<typeof ExpressionMultiSpeciesBundleSchema>;
+export declare const ClinvarBundleSchema: z.ZodObject<{
+    totalFound: z.ZodNumber;
+    variants: z.ZodArray<z.ZodObject<{
+        variationId: z.ZodString;
+        title: z.ZodString;
+        clinicalSignificance: z.ZodString;
+        reviewStatus: z.ZodString;
+        conditions: z.ZodArray<z.ZodString>;
+        molecularConsequence: z.ZodString;
+        accession: z.ZodString;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type ClinvarBundle = z.infer<typeof ClinvarBundleSchema>;
+export declare const CbioportalBundleSchema: z.ZodObject<{
+    entrezGeneId: z.ZodNullable<z.ZodNumber>;
+    rows: z.ZodArray<z.ZodObject<{
+        cancerTypeId: z.ZodString;
+        cancerTypeName: z.ZodString;
+        totalSamples: z.ZodNumber;
+        mutatedSamples: z.ZodNumber;
+        frequency: z.ZodNumber;
+        studies: z.ZodArray<z.ZodString>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type CbioportalBundle = z.infer<typeof CbioportalBundleSchema>;
+export declare const ImpcBundleSchema: z.ZodObject<{
+    mouseMarkerSymbol: z.ZodNullable<z.ZodString>;
+    mgiAccessionId: z.ZodNullable<z.ZodString>;
+    viability: z.ZodNullable<z.ZodEnum<{
+        lethal_pre_weaning: "lethal_pre_weaning";
+        subviable: "subviable";
+        viable: "viable";
+    }>>;
+    viabilityCalls: z.ZodArray<z.ZodObject<{
+        zygosity: z.ZodString;
+        parameterStableId: z.ZodString;
+        mpTerm: z.ZodNullable<z.ZodObject<{
+            id: z.ZodString;
+            name: z.ZodString;
+        }, z.core.$strip>>;
+    }, z.core.$strip>>;
+    mpTerms: z.ZodArray<z.ZodObject<{
+        id: z.ZodString;
+        term: z.ZodString;
+        bestPValue: z.ZodNullable<z.ZodNumber>;
+    }, z.core.$strip>>;
+    organSystems: z.ZodArray<z.ZodString>;
+    sexDimorphic: z.ZodBoolean;
+    phenotypeCount: z.ZodNumber;
+}, z.core.$strip>;
+export type ImpcBundle = z.infer<typeof ImpcBundleSchema>;
+export declare const PubmedIndexBundleSchema: z.ZodObject<{
+    totalFound: z.ZodNumber;
+    topPmids: z.ZodArray<z.ZodString>;
+    results: z.ZodArray<z.ZodObject<{
+        pmid: z.ZodString;
+        title: z.ZodString;
+        journal: z.ZodString;
+        year: z.ZodString;
+        authors: z.ZodString;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type PubmedIndexBundle = z.infer<typeof PubmedIndexBundleSchema>;
+export declare const PathwaysBundleSchema: z.ZodObject<{
+    pathways: z.ZodArray<z.ZodObject<{
+        id: z.ZodString;
+        name: z.ZodString;
+        source: z.ZodEnum<{
+            kegg: "kegg";
+            reactome: "reactome";
+        }>;
+        url: z.ZodOptional<z.ZodString>;
+        entity_uniprots: z.ZodOptional<z.ZodArray<z.ZodString>>;
+        metadata: z.ZodOptional<z.ZodObject<{
+            species_present: z.ZodOptional<z.ZodArray<z.ZodString>>;
+        }, z.core.$strip>>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type PathwaysBundle = z.infer<typeof PathwaysBundleSchema>;
+export declare const StringPpiBundleSchema: z.ZodObject<{
+    partners: z.ZodArray<z.ZodObject<{
+        proteinA: z.ZodString;
+        proteinB: z.ZodString;
+        score: z.ZodNumber;
+        experimentalScore: z.ZodOptional<z.ZodNumber>;
+        databaseScore: z.ZodOptional<z.ZodNumber>;
+        textminingScore: z.ZodOptional<z.ZodNumber>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type StringPpiBundle = z.infer<typeof StringPpiBundleSchema>;
+/**
+ * Heterodimer / receptor-accessory complex inventory for the assessment
+ * target, sourced from IUPHAR Guide to Pharmacology. Drives runtime
+ * heterodimer-name detection (no hardcoded RAMP/MRAP/RGS regex) and the
+ * obligate-cofactor supplement in the off-target panel.
+ */
+export declare const FamilyComplexesBundleSchema: z.ZodObject<{
+    primaryTargetGene: z.ZodString;
+    primaryTargetUniprot: z.ZodNullable<z.ZodString>;
+    accessoryProteinNames: z.ZodArray<z.ZodString>;
+    complexes: z.ZodArray<z.ZodObject<{
+        complexName: z.ZodString;
+        complexId: z.ZodNullable<z.ZodNumber>;
+        accessoryNames: z.ZodArray<z.ZodString>;
+        subunitNames: z.ZodArray<z.ZodString>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type FamilyComplexesBundle = z.infer<typeof FamilyComplexesBundleSchema>;
+export declare const TherapeuticProgramsBundleSchema: z.ZodObject<{
+    programs: z.ZodArray<z.ZodObject<{
+        programId: z.ZodString;
+        name: z.ZodString;
+        targetSymbol: z.ZodString;
+        targetUniprot: z.ZodNullable<z.ZodString>;
+        modality: z.ZodString;
+        sponsor: z.ZodNullable<z.ZodString>;
+        mechanism: z.ZodString;
+        status: z.ZodString;
+        nctIds: z.ZodArray<z.ZodString>;
+        pmids: z.ZodArray<z.ZodString>;
+        evidence: z.ZodArray<z.ZodObject<{
+            pmid: z.ZodOptional<z.ZodString>;
+            doi: z.ZodOptional<z.ZodString>;
+            source: z.ZodString;
+            predicate: z.ZodOptional<z.ZodString>;
+            score: z.ZodOptional<z.ZodNumber>;
+            strength: z.ZodOptional<z.ZodString>;
+            is_human: z.ZodOptional<z.ZodBoolean>;
+            is_clinical: z.ZodOptional<z.ZodBoolean>;
+            excerpt: z.ZodOptional<z.ZodString>;
+            metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
+            regulatory_reference: z.ZodOptional<z.ZodObject<{
+                document: z.ZodString;
+                section: z.ZodOptional<z.ZodString>;
+                doc_id: z.ZodOptional<z.ZodString>;
+                doc_url: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>>;
+        confidence: z.ZodEnum<{
+            high: "high";
+            medium: "medium";
+            low: "low";
+        }>;
+    }, z.core.$strip>>;
+}, z.core.$strip>;
+export type TherapeuticProgramsBundle = z.infer<typeof TherapeuticProgramsBundleSchema>;
+export declare const Phase1BundleSchema: z.ZodObject<{
+    resolved: z.ZodObject<{
+        assessmentId: z.ZodString;
+        goal: z.ZodNullable<z.ZodString>;
+        canonicalId: z.ZodString;
+        canonicalOntology: z.ZodEnum<{
+            ensembl: "ensembl";
+            hgnc: "hgnc";
+        }>;
+        geneSymbol: z.ZodString;
+        approvedName: z.ZodString;
+        ids: z.ZodObject<{
+            hgnc: z.ZodNullable<z.ZodString>;
+            ensembl: z.ZodNullable<z.ZodString>;
+            uniprot: z.ZodNullable<z.ZodString>;
+            chembl: z.ZodNullable<z.ZodString>;
+            entrez: z.ZodNullable<z.ZodString>;
+        }, z.core.$strip>;
+        synonyms: z.ZodArray<z.ZodString>;
+        proteinSynonyms: z.ZodArray<z.ZodString>;
+        proteinFamily: z.ZodNullable<z.ZodString>;
+        resolutionCoverage: z.ZodObject<{
+            hgnc: z.ZodBoolean;
+            uniprot: z.ZodBoolean;
+            ensembl: z.ZodBoolean;
+            chembl: z.ZodBoolean;
+        }, z.core.$strip>;
+    }, z.core.$strip>;
+    collectors: z.ZodObject<{
+        opentargets: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                ensemblId: z.ZodString;
+                approvedSymbol: z.ZodString;
+                approvedName: z.ZodString;
+                tractability: z.ZodNullable<z.ZodObject<{
+                    smallMolecule: z.ZodNullable<z.ZodBoolean>;
+                    antibody: z.ZodNullable<z.ZodBoolean>;
+                    otherModalities: z.ZodNullable<z.ZodBoolean>;
+                }, z.core.$strip>>;
+                associations: z.ZodArray<z.ZodObject<{
+                    diseaseId: z.ZodString;
+                    diseaseName: z.ZodString;
+                    score: z.ZodNumber;
+                    geneticAssociationScore: z.ZodNullable<z.ZodNumber>;
+                    knownDrugScore: z.ZodNullable<z.ZodNumber>;
+                    literatureScore: z.ZodNullable<z.ZodNumber>;
+                    animalModelScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
+                    somaticMutationScore: z.ZodDefault<z.ZodNullable<z.ZodNumber>>;
+                    literaturePmids: z.ZodDefault<z.ZodArray<z.ZodString>>;
+                }, z.core.$strip>>;
+                safetyLiabilities: z.ZodArray<z.ZodObject<{
+                    event: z.ZodString;
+                    biosamples: z.ZodArray<z.ZodString>;
+                    effects: z.ZodNullable<z.ZodString>;
+                    source: z.ZodString;
+                }, z.core.$strip>>;
+                baselineExpression: z.ZodArray<z.ZodObject<{
+                    tissueId: z.ZodString;
+                    tissueLabel: z.ZodString;
+                    organSystem: z.ZodNullable<z.ZodString>;
+                    rna: z.ZodNullable<z.ZodObject<{
+                        value: z.ZodNumber;
+                        unit: z.ZodString;
+                    }, z.core.$strip>>;
+                    protein: z.ZodNullable<z.ZodObject<{
+                        level: z.ZodNullable<z.ZodNumber>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        chemblModulators: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                targetChemblId: z.ZodNullable<z.ZodString>;
+                modulators: z.ZodArray<z.ZodObject<{
+                    moleculeChemblId: z.ZodString;
+                    parentChemblId: z.ZodNullable<z.ZodString>;
+                    preferredName: z.ZodNullable<z.ZodString>;
+                    maxPhase: z.ZodNullable<z.ZodNumber>;
+                    moleculeType: z.ZodNullable<z.ZodString>;
+                    firstApproval: z.ZodNullable<z.ZodNumber>;
+                    evidence_source: z.ZodOptional<z.ZodLiteral<"chembl_activity">>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        ctgov: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                active: z.ZodArray<z.ZodObject<{
+                    nctId: z.ZodString;
+                    title: z.ZodString;
+                    officialTitle: z.ZodNullable<z.ZodString>;
+                    status: z.ZodString;
+                    phase: z.ZodNullable<z.ZodString>;
+                    studyType: z.ZodNullable<z.ZodString>;
+                    primaryPurpose: z.ZodNullable<z.ZodString>;
+                    conditions: z.ZodArray<z.ZodString>;
+                    interventions: z.ZodArray<z.ZodString>;
+                    interventionDetails: z.ZodArray<z.ZodObject<{
+                        name: z.ZodString;
+                        type: z.ZodNullable<z.ZodString>;
+                        description: z.ZodNullable<z.ZodString>;
+                        otherNames: z.ZodArray<z.ZodString>;
+                    }, z.core.$strip>>;
+                    enrollmentCount: z.ZodNullable<z.ZodNumber>;
+                    startDate: z.ZodNullable<z.ZodString>;
+                    primaryCompletionDate: z.ZodNullable<z.ZodString>;
+                    whyStopped: z.ZodNullable<z.ZodString>;
+                    briefSummary: z.ZodNullable<z.ZodString>;
+                    detailedDescription: z.ZodNullable<z.ZodString>;
+                    sponsor: z.ZodNullable<z.ZodString>;
+                    collection_query: z.ZodOptional<z.ZodString>;
+                    collection_channel: z.ZodOptional<z.ZodEnum<{
+                        class_modulator: "class_modulator";
+                        target_symbol: "target_symbol";
+                        therapeutic_program: "therapeutic_program";
+                        biomarker_context: "biomarker_context";
+                        failed_intervention: "failed_intervention";
+                    }>>;
+                }, z.core.$strip>>;
+                failed: z.ZodArray<z.ZodObject<{
+                    nctId: z.ZodString;
+                    title: z.ZodString;
+                    officialTitle: z.ZodNullable<z.ZodString>;
+                    status: z.ZodString;
+                    phase: z.ZodNullable<z.ZodString>;
+                    studyType: z.ZodNullable<z.ZodString>;
+                    primaryPurpose: z.ZodNullable<z.ZodString>;
+                    conditions: z.ZodArray<z.ZodString>;
+                    interventions: z.ZodArray<z.ZodString>;
+                    interventionDetails: z.ZodArray<z.ZodObject<{
+                        name: z.ZodString;
+                        type: z.ZodNullable<z.ZodString>;
+                        description: z.ZodNullable<z.ZodString>;
+                        otherNames: z.ZodArray<z.ZodString>;
+                    }, z.core.$strip>>;
+                    enrollmentCount: z.ZodNullable<z.ZodNumber>;
+                    startDate: z.ZodNullable<z.ZodString>;
+                    primaryCompletionDate: z.ZodNullable<z.ZodString>;
+                    whyStopped: z.ZodNullable<z.ZodString>;
+                    briefSummary: z.ZodNullable<z.ZodString>;
+                    detailedDescription: z.ZodNullable<z.ZodString>;
+                    sponsor: z.ZodNullable<z.ZodString>;
+                    collection_query: z.ZodOptional<z.ZodString>;
+                    collection_channel: z.ZodOptional<z.ZodEnum<{
+                        class_modulator: "class_modulator";
+                        target_symbol: "target_symbol";
+                        therapeutic_program: "therapeutic_program";
+                        biomarker_context: "biomarker_context";
+                        failed_intervention: "failed_intervention";
+                    }>>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        faersByTarget: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                drugProbed: z.ZodString;
+                totalReports: z.ZodNullable<z.ZodNumber>;
+                topReactions: z.ZodArray<z.ZodObject<{
+                    reaction: z.ZodString;
+                    count: z.ZodNumber;
+                }, z.core.$strip>>;
+                seriousness: z.ZodNullable<z.ZodObject<{
+                    totalReports: z.ZodNumber;
+                    fatalCount: z.ZodNumber;
+                    hospitalizationCount: z.ZodNumber;
+                    lifeThreateningCount: z.ZodNumber;
+                    disablingCount: z.ZodNumber;
+                    congenitalAnomalyCount: z.ZodDefault<z.ZodNumber>;
+                    otherSeriousCount: z.ZodDefault<z.ZodNumber>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        expressionHuman: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                source: z.ZodEnum<{
+                    gtex: "gtex";
+                    hpa_consensus: "hpa_consensus";
+                    hpa_rna_tissue: "hpa_rna_tissue";
+                }>;
+                unit: z.ZodEnum<{
+                    tpm: "tpm";
+                    ntpm: "ntpm";
+                    consensus_normalized: "consensus_normalized";
+                }>;
+                normalization_notes: z.ZodString;
+                tissues: z.ZodArray<z.ZodObject<{
+                    tissueLabel: z.ZodString;
+                    organSystem: z.ZodNullable<z.ZodString>;
+                    value: z.ZodNullable<z.ZodNumber>;
+                    protein: z.ZodNullable<z.ZodNumber>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        expressionMultiSpecies: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                geneSymbol: z.ZodString;
+                humanEnsemblId: z.ZodNullable<z.ZodString>;
+                bySpecies: z.ZodArray<z.ZodObject<{
+                    species: z.ZodString;
+                    taxonId: z.ZodNumber;
+                    ensemblId: z.ZodString;
+                    source: z.ZodString;
+                    unit: z.ZodString;
+                    normalization_notes: z.ZodString;
+                    tissues: z.ZodArray<z.ZodObject<{
+                        tissue: z.ZodString;
+                        rank: z.ZodEnum<{
+                            high: "high";
+                            medium: "medium";
+                            low: "low";
+                            absent: "absent";
+                        }>;
+                        expressionScore: z.ZodNullable<z.ZodNumber>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>>;
+                notFound: z.ZodArray<z.ZodString>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        clinvar: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                totalFound: z.ZodNumber;
+                variants: z.ZodArray<z.ZodObject<{
+                    variationId: z.ZodString;
+                    title: z.ZodString;
+                    clinicalSignificance: z.ZodString;
+                    reviewStatus: z.ZodString;
+                    conditions: z.ZodArray<z.ZodString>;
+                    molecularConsequence: z.ZodString;
+                    accession: z.ZodString;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        cbioportal: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                entrezGeneId: z.ZodNullable<z.ZodNumber>;
+                rows: z.ZodArray<z.ZodObject<{
+                    cancerTypeId: z.ZodString;
+                    cancerTypeName: z.ZodString;
+                    totalSamples: z.ZodNumber;
+                    mutatedSamples: z.ZodNumber;
+                    frequency: z.ZodNumber;
+                    studies: z.ZodArray<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        impc: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                mouseMarkerSymbol: z.ZodNullable<z.ZodString>;
+                mgiAccessionId: z.ZodNullable<z.ZodString>;
+                viability: z.ZodNullable<z.ZodEnum<{
+                    lethal_pre_weaning: "lethal_pre_weaning";
+                    subviable: "subviable";
+                    viable: "viable";
+                }>>;
+                viabilityCalls: z.ZodArray<z.ZodObject<{
+                    zygosity: z.ZodString;
+                    parameterStableId: z.ZodString;
+                    mpTerm: z.ZodNullable<z.ZodObject<{
+                        id: z.ZodString;
+                        name: z.ZodString;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>>;
+                mpTerms: z.ZodArray<z.ZodObject<{
+                    id: z.ZodString;
+                    term: z.ZodString;
+                    bestPValue: z.ZodNullable<z.ZodNumber>;
+                }, z.core.$strip>>;
+                organSystems: z.ZodArray<z.ZodString>;
+                sexDimorphic: z.ZodBoolean;
+                phenotypeCount: z.ZodNumber;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        pubmedIndex: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                totalFound: z.ZodNumber;
+                topPmids: z.ZodArray<z.ZodString>;
+                results: z.ZodArray<z.ZodObject<{
+                    pmid: z.ZodString;
+                    title: z.ZodString;
+                    journal: z.ZodString;
+                    year: z.ZodString;
+                    authors: z.ZodString;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        pathways: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                pathways: z.ZodArray<z.ZodObject<{
+                    id: z.ZodString;
+                    name: z.ZodString;
+                    source: z.ZodEnum<{
+                        kegg: "kegg";
+                        reactome: "reactome";
+                    }>;
+                    url: z.ZodOptional<z.ZodString>;
+                    entity_uniprots: z.ZodOptional<z.ZodArray<z.ZodString>>;
+                    metadata: z.ZodOptional<z.ZodObject<{
+                        species_present: z.ZodOptional<z.ZodArray<z.ZodString>>;
+                    }, z.core.$strip>>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        stringPpi: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                partners: z.ZodArray<z.ZodObject<{
+                    proteinA: z.ZodString;
+                    proteinB: z.ZodString;
+                    score: z.ZodNumber;
+                    experimentalScore: z.ZodOptional<z.ZodNumber>;
+                    databaseScore: z.ZodOptional<z.ZodNumber>;
+                    textminingScore: z.ZodOptional<z.ZodNumber>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        familyComplexes: z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                primaryTargetGene: z.ZodString;
+                primaryTargetUniprot: z.ZodNullable<z.ZodString>;
+                accessoryProteinNames: z.ZodArray<z.ZodString>;
+                complexes: z.ZodArray<z.ZodObject<{
+                    complexName: z.ZodString;
+                    complexId: z.ZodNullable<z.ZodNumber>;
+                    accessoryNames: z.ZodArray<z.ZodString>;
+                    subunitNames: z.ZodArray<z.ZodString>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">;
+        therapeuticPrograms: z.ZodOptional<z.ZodDiscriminatedUnion<[z.ZodObject<{
+            coverage: z.ZodLiteral<"available">;
+            data: z.ZodObject<{
+                programs: z.ZodArray<z.ZodObject<{
+                    programId: z.ZodString;
+                    name: z.ZodString;
+                    targetSymbol: z.ZodString;
+                    targetUniprot: z.ZodNullable<z.ZodString>;
+                    modality: z.ZodString;
+                    sponsor: z.ZodNullable<z.ZodString>;
+                    mechanism: z.ZodString;
+                    status: z.ZodString;
+                    nctIds: z.ZodArray<z.ZodString>;
+                    pmids: z.ZodArray<z.ZodString>;
+                    evidence: z.ZodArray<z.ZodObject<{
+                        pmid: z.ZodOptional<z.ZodString>;
+                        doi: z.ZodOptional<z.ZodString>;
+                        source: z.ZodString;
+                        predicate: z.ZodOptional<z.ZodString>;
+                        score: z.ZodOptional<z.ZodNumber>;
+                        strength: z.ZodOptional<z.ZodString>;
+                        is_human: z.ZodOptional<z.ZodBoolean>;
+                        is_clinical: z.ZodOptional<z.ZodBoolean>;
+                        excerpt: z.ZodOptional<z.ZodString>;
+                        metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
+                        regulatory_reference: z.ZodOptional<z.ZodObject<{
+                            document: z.ZodString;
+                            section: z.ZodOptional<z.ZodString>;
+                            doc_id: z.ZodOptional<z.ZodString>;
+                            doc_url: z.ZodOptional<z.ZodString>;
+                        }, z.core.$strip>>;
+                    }, z.core.$strip>>;
+                    confidence: z.ZodEnum<{
+                        high: "high";
+                        medium: "medium";
+                        low: "low";
+                    }>;
+                }, z.core.$strip>>;
+            }, z.core.$strip>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"queried_no_data">;
+            error: z.ZodOptional<z.ZodObject<{
+                message: z.ZodString;
+                name: z.ZodOptional<z.ZodString>;
+                stack: z.ZodOptional<z.ZodString>;
+            }, z.core.$strip>>;
+        }, z.core.$strip>, z.ZodObject<{
+            coverage: z.ZodLiteral<"not_loaded">;
+            reason: z.ZodOptional<z.ZodString>;
+        }, z.core.$strip>], "coverage">>;
+    }, z.core.$strip>;
+}, z.core.$strip>;
+export type Phase1Bundle = z.infer<typeof Phase1BundleSchema>;