@erosolaraijs/cure 2.3.1 → 2.5.0

package/src/capabilities/index.ts

@@ -53,3 +53,184 @@ export {
   type CureVerification,
   type ComprehensiveCoverageReport
 } from './cureValidationFramework.js';
+
+// Resistance Management - Overcome all treatment resistance mechanisms
+export {
+  ResistanceManagementEngine,
+  resistanceManagementEngine,
+  CureVerificationEngine,
+  cureVerificationEngine,
+  RESISTANCE_MECHANISM_DATABASE,
+  RESISTANCE_MONITORING_PROTOCOLS,
+  type ResistanceMechanism,
+  type OvercomingStrategy,
+  type ResistanceMonitoringPlan,
+  type CureVerificationResult
+} from './resistanceManagement.js';
+
+// Treatment Sequencing - Optimal line-of-therapy protocols
+export {
+  TreatmentSequencingEngine,
+  treatmentSequencingEngine,
+  NSCLC_TREATMENT_SEQUENCES,
+  BREAST_CANCER_TREATMENT_SEQUENCES,
+  COLORECTAL_CANCER_TREATMENT_SEQUENCES,
+  type TreatmentLine,
+  type TherapyRegimen,
+  type DrugComponent,
+  type SelectionCriteria,
+  type BiomarkerRequirement,
+  type ResponseAssessment,
+  type SwitchingCriteria,
+  type CancerTreatmentSequence,
+  type SpecialPathway,
+  type MaintenanceProtocol,
+  type RechallengeProtocol
+} from './treatmentSequencing.js';
+
+// Emergency Oncology - Life-saving protocols for oncologic emergencies
+export {
+  EmergencyOncologyEngine,
+  emergencyOncologyEngine,
+  STRUCTURAL_EMERGENCIES,
+  METABOLIC_EMERGENCIES,
+  TREATMENT_RELATED_EMERGENCIES,
+  HEMATOLOGIC_EMERGENCIES,
+  type OncologicEmergency,
+  type EmergencyCategory,
+  type RecognitionCriteria,
+  type EmergencyManagement,
+  type MedicationOrder,
+  type DefinitiveManagement,
+  type MonitoringProtocol,
+  type OutcomeExpectations
+} from './emergencyOncology.js';
+
+// Survivorship Management - Long-term care and late effects
+export {
+  SurvivorshipCareEngine,
+  survivorshipCareEngine,
+  SURVEILLANCE_PROTOCOLS,
+  LATE_EFFECTS_PROTOCOLS,
+  SECONDARY_MALIGNANCY_SCREENING,
+  PSYCHOSOCIAL_SUPPORT_FRAMEWORK,
+  EXERCISE_RECOMMENDATIONS,
+  HEALTH_MAINTENANCE_RECOMMENDATIONS,
+  type SurvivorshipCareplan,
+  type TreatmentSummary,
+  type SurgicalSummary,
+  type RadiationSummary,
+  type SystemicTherapySummary,
+  type SurveillanceProtocol,
+  type SurveillanceVisit,
+  type LateEffectsScreening,
+  type LateEffectRisk,
+  type SecondaryMalignancyScreen,
+  type PsychosocialPlan,
+  type RehabilitationPlan,
+  type ExerciseRecommendation,
+  type HealthMaintenance
+} from './survivorshipManagement.js';
+
+// Universal Cancer Cure Engine - Complete integration of all capabilities
+export {
+  UniversalCancerCureEngine,
+  universalCancerCureEngine,
+  COMPREHENSIVE_CANCER_TAXONOMY,
+  ACTIONABLE_BIOMARKERS,
+  SPECIAL_POPULATION_PROTOCOLS,
+  type ComprehensiveBiomarkerPanel,
+  type TreatmentPathway,
+  type TreatmentLine as UnifiedTreatmentLine,
+  type TreatmentRegimen as UnifiedTreatmentRegimen,
+  type ResponseMonitoring,
+  type ResistanceStrategy,
+  type UniversalCureResult
+} from './universalCancerCureEngine.js';
+
+// Palliative Care - Comprehensive pain and symptom management
+export {
+  PalliativeCareEngine,
+  palliativeCareEngine,
+  WHO_PAIN_LADDER,
+  NEUROPATHIC_PAIN_PROTOCOLS,
+  CIPN_PROTOCOLS,
+  BONE_PAIN_PROTOCOL,
+  CANCER_SYMPTOM_CLUSTERS,
+  END_OF_LIFE_PROTOCOLS,
+  PALLIATIVE_SEDATION_PROTOCOL,
+  OPIOID_EQUIVALENCE_TABLE,
+  type PainAssessment,
+  type PainManagementProtocol,
+  type PainIntervention,
+  type CIPNProtocol,
+  type SymptomCluster,
+  type EndOfLifeProtocol,
+  type OpioidEquivalence
+} from './palliativeCareModule.js';
+
+// Precision Medicine - Genomic interpretation and biomarker-driven therapy
+export {
+  PrecisionMedicineEngine,
+  precisionMedicineEngine,
+  ACTIONABLE_GENOMIC_DATABASE,
+  PHARMACOGENOMIC_MARKERS,
+  TME_THERAPEUTIC_IMPLICATIONS,
+  type GenomicAlteration,
+  type ActionabilityLevel,
+  type TargetedTherapy,
+  type PharmacogenomicMarker,
+  type TumorMicroenvironment,
+  type LiquidBiopsyResult,
+  type CtDNAInterpretation
+} from './precisionMedicineModule.js';
+
+// Multimodal Oncology - Radiation and Surgical Integration
+export {
+  MultimodalOncologyEngine,
+  multimodalOncologyEngine,
+  RADIATION_PROTOCOLS,
+  SURGICAL_PROTOCOLS,
+  MULTIMODAL_SEQUENCES,
+  type RadiationProtocol,
+  type RadiationTechnique,
+  type FractionationScheme,
+  type OARConstraint,
+  type SurgicalProcedure,
+  type SurgicalApproach,
+  type MultimodalSequence
+} from './multimodalOncologyModule.js';
+
+// Clinical Trial Matching - Connect patients to novel therapies
+export {
+  ClinicalTrialMatchingEngine,
+  clinicalTrialMatchingEngine,
+  TRIAL_DATABASE,
+  type ClinicalTrial,
+  type TrialPhase,
+  type TrialIntervention,
+  type EligibilityCriteria,
+  type TrialLocation,
+  type PatientTrialProfile,
+  type TrialMatch
+} from './clinicalTrialMatchingModule.js';
+
+// Special Populations - Pediatric, Geriatric, Pregnancy, HIV, Organ Dysfunction
+export {
+  SpecialPopulationsEngine,
+  specialPopulationsEngine,
+  PEDIATRIC_DOSING_PROTOCOLS,
+  COMPREHENSIVE_GERIATRIC_ASSESSMENT,
+  GERIATRIC_DOSING_ADJUSTMENTS,
+  PREGNANCY_CANCER_PROTOCOLS,
+  ORGAN_DYSFUNCTION_DOSING,
+  HIV_ONCOLOGY_PROTOCOLS,
+  calculateBSA,
+  calculatePediatricDose,
+  type PediatricDosingProtocol,
+  type GeriatricAssessment,
+  type GeriatricDosingAdjustment,
+  type PregnancyCancerProtocol,
+  type OrganDysfunctionDosing,
+  type HIVOncologyProtocol
+} from './specialPopulationsModule.js';