@erosolaraijs/cure 2.3.1 → 2.5.0

package/dist/capabilities/precisionMedicineModule.js.map

@@ -0,0 +1 @@
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package/dist/capabilities/specialPopulationsModule.d.ts

@@ -0,0 +1,126 @@
+/**
+ * Special Populations Oncology Module
+ *
+ * ╔═══════════════════════════════════════════════════════════════════════════════╗
+ * ║  SPECIAL POPULATIONS - COMPREHENSIVE PROTOCOLS FOR ALL PATIENTS              ║
+ * ╠═══════════════════════════════════════════════════════════════════════════════╣
+ * ║  This module provides:                                                        ║
+ * ║  - Pediatric dosing calculations and protocols                               ║
+ * ║  - Geriatric assessment and dose modifications                               ║
+ * ║  - Pregnancy-specific management by trimester                                ║
+ * ║  - Organ dysfunction dosing adjustments                                      ║
+ * ║  - HIV/AIDS oncology protocols                                               ║
+ * ║  - Drug interaction safety checking                                          ║
+ * ╚═══════════════════════════════════════════════════════════════════════════════╝
+ */
+export interface PediatricDosingProtocol {
+    drug: string;
+    indication: string[];
+    dosingMethod: 'BSA' | 'Weight' | 'Age-based' | 'Fixed';
+    standardDose: string;
+    maxDose: string;
+    ageAdjustments: AgeAdjustment[];
+    organFunctionAdjustments: string[];
+    formulations: string[];
+    administrationNotes: string[];
+    monitoringRequirements: string[];
+}
+export interface AgeAdjustment {
+    ageGroup: 'Neonate (<1 mo)' | 'Infant (1-12 mo)' | 'Toddler (1-3 yr)' | 'Child (3-12 yr)' | 'Adolescent (12-18 yr)';
+    adjustment: string;
+    rationale: string;
+}
+export declare function calculateBSA(weight: number, height: number): number;
+export declare function calculatePediatricDose(adultDose: number, patientBSA: number, dosingMethod: 'BSA' | 'Weight' | 'Fixed', weight?: number): {
+    dose: number;
+    unit: string;
+    notes: string[];
+};
+export declare const PEDIATRIC_DOSING_PROTOCOLS: PediatricDosingProtocol[];
+export interface GeriatricAssessment {
+    domain: string;
+    tool: string;
+    interpretation: AssessmentInterpretation[];
+    treatmentImplications: string[];
+}
+export interface AssessmentInterpretation {
+    score: string;
+    category: string;
+    meaning: string;
+}
+export interface GeriatricDosingAdjustment {
+    drug: string;
+    standardDose: string;
+    geriatricConsiderations: string[];
+    doseModification: string;
+    alternativeAgents?: string[];
+    monitoringIntensification: string[];
+}
+export declare const COMPREHENSIVE_GERIATRIC_ASSESSMENT: GeriatricAssessment[];
+export declare const GERIATRIC_DOSING_ADJUSTMENTS: GeriatricDosingAdjustment[];
+export interface PregnancyCancerProtocol {
+    trimester: 'First' | 'Second' | 'Third';
+    generalPrinciples: string[];
+    allowedTreatments: TreatmentSafety[];
+    contraindicated: string[];
+    fetalMonitoring: string[];
+    deliveryConsiderations: string[];
+}
+export interface TreatmentSafety {
+    modality: string;
+    safety: 'Generally Safe' | 'Use with Caution' | 'Limited Data' | 'Contraindicated';
+    evidence: string;
+    specificAgents?: string[];
+}
+export declare const PREGNANCY_CANCER_PROTOCOLS: PregnancyCancerProtocol[];
+export interface OrganDysfunctionDosing {
+    drug: string;
+    renalDosing: RenalDosing[];
+    hepaticDosing: HepaticDosing[];
+    dialysisGuidance?: string;
+}
+export interface RenalDosing {
+    crclRange: string;
+    adjustment: string;
+}
+export interface HepaticDosing {
+    bilirubinRange: string;
+    astAltRange: string;
+    adjustment: string;
+}
+export declare const ORGAN_DYSFUNCTION_DOSING: OrganDysfunctionDosing[];
+export interface HIVOncologyProtocol {
+    cancerType: string;
+    artInteractions: ARTInteraction[];
+    treatmentModifications: string[];
+    prophylaxisRequirements: string[];
+    monitoringIntensification: string[];
+    prognosticConsiderations: string;
+}
+export interface ARTInteraction {
+    artClass: string;
+    interaction: string;
+    management: string;
+}
+export declare const HIV_ONCOLOGY_PROTOCOLS: HIVOncologyProtocol[];
+export declare class SpecialPopulationsEngine {
+    calculatePediatricDose(drug: string, weight: number, height: number, age: number): {
+        dose: string;
+        adjustments: string[];
+        monitoring: string[];
+    };
+    performGeriatricAssessment(scores: Record<string, number>): {
+        riskCategory: 'Fit' | 'Vulnerable' | 'Frail';
+        recommendations: string[];
+        treatmentImplications: string[];
+    };
+    getPregnancyGuidelines(trimester: PregnancyCancerProtocol['trimester']): PregnancyCancerProtocol | undefined;
+    getOrganDysfunctionDosing(drug: string, crcl?: number, bilirubin?: number): {
+        renalAdjustment: string;
+        hepaticAdjustment: string;
+    };
+    getHIVOncologyProtocol(cancerType: string): HIVOncologyProtocol | undefined;
+    getGeriatricDosingAdjustment(drug: string): GeriatricDosingAdjustment | undefined;
+}
+export declare const specialPopulationsEngine: SpecialPopulationsEngine;
+//# sourceMappingURL=specialPopulationsModule.d.ts.map

package/dist/capabilities/specialPopulationsModule.d.ts.map

@@ -0,0 +1 @@
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