oddb.org 1.0.0 → 1.0.1

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Files changed (141) hide show
  1. data/.gemtest +0 -0
  2. data/Guide.txt +23 -17
  3. data/{README → INSTALL_from_Source.txt} +64 -75
  4. data/Manifest.txt +110 -4
  5. data/README.txt +4 -2
  6. data/Rakefile +5 -0
  7. data/doc/favicon.ico +0 -0
  8. data/doc/index.rbx +15 -0
  9. data/doc/resources/anthroposophy/favicon.ico +0 -0
  10. data/doc/resources/anthroposophy/logo.png +0 -0
  11. data/doc/resources/atupri/logo.gif +0 -0
  12. data/doc/resources/desitin/logo.jpg +0 -0
  13. data/doc/resources/downloads/datadesc/analysis.csv.txt +57 -0
  14. data/doc/resources/downloads/datadesc/doctors.csv.txt +43 -0
  15. data/doc/resources/downloads/datadesc/doctors.yaml.txt +52 -0
  16. data/doc/resources/downloads/datadesc/fachinfo.yaml.txt +107 -0
  17. data/doc/resources/downloads/datadesc/generics.xls.txt +42 -0
  18. data/doc/resources/downloads/datadesc/index_therapeuticus.txt +38 -0
  19. data/doc/resources/downloads/datadesc/interactions.yaml.txt +78 -0
  20. data/doc/resources/downloads/datadesc/migel.csv.txt +84 -0
  21. data/doc/resources/downloads/datadesc/narcotics.csv.txt +49 -0
  22. data/doc/resources/downloads/datadesc/narcotics.yaml.txt +40 -0
  23. data/doc/resources/downloads/datadesc/oddb.csv.txt +98 -0
  24. data/doc/resources/downloads/datadesc/oddb.yaml.txt +255 -0
  25. data/doc/resources/downloads/datadesc/oddb2.csv.txt +94 -0
  26. data/doc/resources/downloads/datadesc/oddbdat.txt +228 -0
  27. data/doc/resources/downloads/datadesc/patents.xls.txt +29 -0
  28. data/doc/resources/downloads/datadesc/patinfo.yaml.txt +79 -0
  29. data/doc/resources/downloads/datadesc/price_history.csv.txt +43 -0
  30. data/doc/resources/downloads/datadesc/price_history.yaml.txt +55 -0
  31. data/doc/resources/downloads/datadesc/s31x.txt +40 -0
  32. data/doc/resources/downloads/datadesc/swissdrug-update.xls.txt +59 -0
  33. data/doc/resources/downloads/examples/Inderal.Preisvergleich.csv +19 -0
  34. data/doc/resources/downloads/examples/analysis.csv +35 -0
  35. data/doc/resources/downloads/examples/compendium_ch.oddb.org.firefox.epub +0 -0
  36. data/doc/resources/downloads/examples/compendium_ch.oddb.org.htc.prc +0 -0
  37. data/doc/resources/downloads/examples/compendium_ch.oddb.org.kindle.mobi +0 -0
  38. data/doc/resources/downloads/examples/compendium_ch.oddb.org.stanza.epub +0 -0
  39. data/doc/resources/downloads/examples/doctors.csv +13 -0
  40. data/doc/resources/downloads/examples/doctors.yaml +238 -0
  41. data/doc/resources/downloads/examples/fachinfo.yaml +1255 -0
  42. data/doc/resources/downloads/examples/fachinfos_de.pdf +51565 -0
  43. data/doc/resources/downloads/examples/fachinfos_fr.pdf +52072 -0
  44. data/doc/resources/downloads/examples/generics.xls +0 -0
  45. data/doc/resources/downloads/examples/index_therapeuticus.tar.gz +0 -0
  46. data/doc/resources/downloads/examples/interactions.yaml +161 -0
  47. data/doc/resources/downloads/examples/migel.csv +36 -0
  48. data/doc/resources/downloads/examples/narcotics.yaml +92 -0
  49. data/doc/resources/downloads/examples/oddb.csv +1378 -0
  50. data/doc/resources/downloads/examples/oddb.yaml +14976 -0
  51. data/doc/resources/downloads/examples/oddb2.csv +1566 -0
  52. data/doc/resources/downloads/examples/oddbdat.tar.gz +0 -0
  53. data/doc/resources/downloads/examples/patents.xls +0 -0
  54. data/doc/resources/downloads/examples/patinfo.yaml +2505 -0
  55. data/doc/resources/downloads/examples/price_history.csv +99 -0
  56. data/doc/resources/downloads/examples/price_history.yaml +431 -0
  57. data/doc/resources/downloads/examples/swissdrug-update.xls +0 -0
  58. data/doc/resources/errors/appdown.html +50 -0
  59. data/doc/resources/errors/logo.png +0 -0
  60. data/doc/resources/errors/logo_de.gif +0 -0
  61. data/doc/resources/gcc/banner.gif +0 -0
  62. data/doc/resources/gcc/logo.png +0 -0
  63. data/doc/resources/gcc/logo_de.gif +0 -0
  64. data/doc/resources/gcc/logo_doc.gif +0 -0
  65. data/doc/resources/gcc/logo_fr.gif +0 -0
  66. data/doc/resources/gcc/logo_rss.png +0 -0
  67. data/doc/resources/generika/favicon.ico +0 -0
  68. data/doc/resources/generika/logo.gif +0 -0
  69. data/doc/resources/generika/logo_de.gif +0 -0
  70. data/doc/resources/generika/logo_fr.gif +0 -0
  71. data/doc/resources/homeopathy/favicon.ico +0 -0
  72. data/doc/resources/homeopathy/logo.png +0 -0
  73. data/doc/resources/icon_twitter.gif +0 -0
  74. data/doc/resources/innova/logo.gif +0 -0
  75. data/doc/resources/innova/logo_de.gif +0 -0
  76. data/doc/resources/javascript/admin.js +14 -0
  77. data/doc/resources/javascript/autofill.js +21 -0
  78. data/doc/resources/javascript/bit.ly.js +29 -0
  79. data/doc/resources/javascript/company.js +22 -0
  80. data/doc/resources/javascript/dojo/Editor.js +219 -0
  81. data/doc/resources/javascript/dojo/HtmlEditorToolbar.html +163 -0
  82. data/doc/resources/javascript/dojo/sigma.gif +0 -0
  83. data/doc/resources/javascript/widget/SymbolPalette.js +162 -0
  84. data/doc/resources/javascript/widget/Tooltip.js +85 -0
  85. data/doc/resources/javascript/widget/__package__.js +2 -0
  86. data/doc/resources/livemarks16.png +0 -0
  87. data/doc/resources/mail.gif +0 -0
  88. data/doc/resources/mobile/logo.png +0 -0
  89. data/doc/resources/paypal_donate.gif +0 -0
  90. data/doc/resources/phyto-pharma/favicon.ico +0 -0
  91. data/doc/resources/phyto-pharma/logo.png +0 -0
  92. data/doc/resources/plugins/Generika.cc.gif +0 -0
  93. data/doc/resources/plugins/Generika.cc.html +34 -0
  94. data/doc/resources/plugins/Generika.cc.src +34 -0
  95. data/doc/resources/plugins/oddb.org.gif +0 -0
  96. data/doc/resources/plugins/oddb.org.html +34 -0
  97. data/doc/resources/plugins/oddb.org.src +34 -0
  98. data/doc/resources/print.css +33 -0
  99. data/doc/resources/provita/logo_de.gif +0 -0
  100. data/doc/resources/santesuisse/logo_de.gif +0 -0
  101. data/doc/resources/schoenenberger/logo_de.gif +0 -0
  102. data/doc/resources/swissmedic/logo.png +0 -0
  103. data/doc/resources/swissmedic/logo_de.gif +0 -0
  104. data/doc/resources/swissmedic/logo_doc.gif +0 -0
  105. data/doc/resources/swissmedic/logo_fr.gif +0 -0
  106. data/doc/resources/sympany/logo.gif +0 -0
  107. data/doc/robots.txt +29 -0
  108. data/ext/export/src/generics_xls.rb +29 -5
  109. data/ext/export/src/oddbdat.rb +1 -1
  110. data/ext/export/test/test_generics_xls.rb +216 -0
  111. data/ext/export/test/test_oddbdat.rb +880 -0
  112. data/lib/oddb.org.rb +1 -1
  113. data/src/model/package.rb +3 -2
  114. data/src/plugin/analysis.rb +2 -0
  115. data/src/plugin/bsv_xml.rb +1 -1
  116. data/src/plugin/hospitals.rb +1 -0
  117. data/src/plugin/oddbdat_export.rb +12 -2
  118. data/src/plugin/text_info.rb +16 -29
  119. data/src/util/exporter.rb +21 -1
  120. data/src/util/log.rb +3 -0
  121. data/src/util/oddbapp.rb +1 -1
  122. data/src/util/oddbconfig.rb +1 -1
  123. data/src/util/updater.rb +9 -1
  124. data/test/data/html/interaction/flockhart/prepared_table.asp +820 -0
  125. data/test/data/html/interaction/flockhart/table.asp +820 -0
  126. data/test/data/html/text_info/News.html +18 -93
  127. data/test/suite.rb +78 -4
  128. data/test/test_model/package.rb +38 -0
  129. data/test/test_plugin/bsv_xml.rb +4 -2
  130. data/test/test_plugin/flockhart.rb +1 -1
  131. data/test/test_plugin/oddbdat_export.rb +79 -658
  132. data/test/test_plugin/ouwerkerk.rb +2 -2
  133. data/test/test_plugin/suite.rb +8 -6
  134. data/test/test_plugin/text_info.rb +40 -52
  135. data/test/test_plugin/{doctors.rb → zdoctor.rb} +0 -0
  136. data/test/test_util/exporter.rb +500 -0
  137. data/test/test_util/suite.rb +8 -6
  138. data/test/test_util/{log.rb → zlog.rb} +19 -0
  139. data/test/test_view/{search.rb → asearch.rb} +0 -0
  140. data/test/test_view/suite.rb +8 -6
  141. metadata +143 -14
data/test/data/html/interaction/flockhart/table.asp ADDED
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+ <!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN">
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+ <html>
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+ <head>
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+
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+ <title>Division of Clinical Pharmacology | Indiana University Department of Medicine</title>
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+
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+ <meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+ <meta name="description" content="">
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+ <meta name="keywords" content="">
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+
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+
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+
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+ <!-- Begin External Style Sheet Calls, based on browser -->
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+ <style type="text/css" media="screen">
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+ @import url(/css_stylesheets/IUSM/body.css);
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+ </style>
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+ <style type="text/css" media="print">
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+ @import url(/css_stylesheets/IUSM/print.css);
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+ </style>
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+ <!--[if IE 8]>
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+ <style type="text/css">
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+ @import url(/css_stylesheets/IUSM/body_ie.css);
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+ </style>
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+ <style type="text/css" media="print">
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+ @import url(/css_stylesheets/IUSM/print.css);
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+ </style>
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+ <![endif]-->
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+ <!--[if IE 7]>
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+ <style type="text/css">
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+ @import url(/css_stylesheets/IUSM/body_ie.css);
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+ </style>
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+ <style type="text/css" media="print">
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+ @import url(/css_stylesheets/IUSM/print.css);
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+ </style>
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+ <![endif]-->
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+ <!--[if lt IE 7.]>
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+ <style type="text/css">
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+ @import url(/css_stylesheets/IUSM/body_ie.css);
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+ @import url(/css_stylesheets/IUSM/body_ie6.css);
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+ </style>
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+ <style type="text/css" media="print">
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+ @import url(/css_stylesheets/IUSM/print.css);
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+ </style>
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+ <![endif]-->
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+ <!-- End External Style Sheet Calls, based on browser -->
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+
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+
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+ </head>
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+
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+ <style>
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+ td {
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+ font-size: 10px;
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+ }
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+ </style>
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+
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+ <body>
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+
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+ <!-- Begin Standard IU Banner and Search -->
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+ <div id="header_span">
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+ <div class="header">
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+
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+ <a href="http://www.indiana.edu">
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+ <img src="/images/Template/iu_logo.jpg" align="left" border="0" title="Indiana University">
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+ </a>
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+
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+ <form method="get" action="http://search2.iu.edu/search" style="padding:0px; margin:0px;">
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+ <input type="hidden" name="client" value="medicine"/>
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+ <input type="hidden" name="proxystylesheet" value="medicine"/>
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+ <input type="hidden" name="output" value="xml_no_dtd"/>
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+ <table border="0" cellpadding="0" cellspacing="0" align="right" style="width:1px; padding-top:2px; padding-bottom:2px;">
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+ <tr>
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+
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+ <!-- Find People - optional, removed
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+ <td align="left" valign="middle" ><a href="http://medicine.iu.edu/body.cfm?id=1816"><img src="/images/Template/people-search.jpg" title="Find People" border="0" style="margin-top:4px;"></a></td>
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+ <td style="color:#FFFFFF; font-family:Verdana; font-size:10px;">&nbsp;&nbsp;|&nbsp; </td>
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+ -->
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+
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+ <td align="left" valign="middle" style="width:1px;"><input type="radio" name="site" value="medicine" checked/></td>
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+ <td align="left" valign="middle" style="width:1px;color:#FFFFFF; font-family:Verdana; font-size:10px;">IUSM</td>
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+ <td align="left" valign="middle" style="width:1px;"><input type="radio" name="site" value="indiana" /></td>
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+ <td align="left" valign="middle" style="width:1px;color:#FFFFFF; font-family:Verdana; font-size:10px;">IU</td>
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+ <td align="left" valign="middle" style="width:1px;padding-left:10px;color:#000000; font-family:Verdana; font-size:10px;">
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+ <input type="text" name="q" size="15" maxlength="255" value="search..." onFocus="this.value=''" class="search"/></td>
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+ <td align="left" valign="middle" style="width:1px; font-weight:bold; font-family:Verdana; font-size:10px;">
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+ <input type="image" src="/images/Template/searchgo.jpg" name="btnG" value="Search" class="searchgo"/></td>
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+ </tr>
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+ </table>
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+ </form>
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+ </div>
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+ </div>
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+
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+ <!-- End Standard IU Banner and Search -->
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+
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+ <!-- Begin Standard IUSM Banner -->
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+ <div class="iusm_banner_span">
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+ <div class="iusm_banner">
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+ <a href="http://medicine.iu.edu">
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+ <img src="/images/Template/IUSM_banner.jpg" align="left" border="0" title="IU School of Medicine">
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+ </a>
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+ <a href="/">
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+ <img src="/images/Template/DoM_banner.jpg" align="left" border="0" title="IU Department of Medicine">
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+ </a>
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+ </div>
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+ </div>
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+ <!-- End Standard IUSM Banner -->
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+
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+ <!-- Begin Standard Department/Division/Office/Entity Banner -->
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+ <div id="banner_span">
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+ <div class="shadow_box">
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+ <div class="banner">
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+ <a href="/"><img src="/images/clinpharm/banner.jpg" border="0" align="left"></a>
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+ </div>
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+ </div>
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+ </div>
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+ <!-- End Standard Department/Division/Office/Entity Banner -->
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+
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+ <!-- Begin Standard Horzontal Nav Bar | Nav Styles moved to an external style sheet -->
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+ <div class="hornav_span">
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+ <div class="hornav_shadow">
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+ <div class="hornav">
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+ <div class="hornav_buttons">
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+
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+ <!-- Begin Horizontal Nav Bar CSS -->
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+ <style type="text/css">
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+ @import url(/css_stylesheets/IUSM/top_nav.css);
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+ </style>
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+ <!-- End Horizontal Nav Bar CSS -->
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+
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+ <!-- Begin Horizontal Nav Bar Content -->
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+ <table border="0" cellspacing="0" cellpadding="0">
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+ <tr>
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+ <td valign="middle" align="right"><a class="NavBarNum1" href="/clinpharm/donations/">Make a Donation</a></td>
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+ <td valign="middle" align="right">&nbsp;|&nbsp;</td>
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+ <td valign="middle" align="right"><a class="NavBarNum1" href="/">Department of Medicine</a></td>
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+ </tr>
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+ </table>
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+ <!-- End Horizontal Nav Bar Content -->
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+
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+ </div>
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+ </div>
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+ </div>
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+ </div>
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+ <!-- End Standard Horzontal Nav Bar -->
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+
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+ <!-- Begin Main Body -->
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+ <div class="shadow_box">
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+ <div class="content_inner">
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+
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+ <!-- Begin Main Body -->
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+
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+ <div class='content' style='width:920px; margin-left:0px; border-left:none;'>
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+
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+ <!-- Begin Breadcrumbs and Back Button -->
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+ <div class="breadcrumbs">
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+ <div style="font-weight:normal; color:#990000; font-size:10px; float:left">
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+ <script language="javascript" src="/includes/clinpharm/breadcrumb.js"></script>
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+ </div>
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+
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+ <div style="margin-right:0px; text-align:right;">
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+ <img src="/images/Template/back_go.gif" title="back" style="margin-bottom:1px;"/>
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+ <a style="font-weight:normal; color:#990000; font-size:10px; cursor:pointer"
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+ onClick="javascript:history.go(-1);">BACK</a><br><br>
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+ </div>
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+ </div>
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+ <div style="clear:both"></div>
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+ <!-- End Breadcrumbs and Back Button -->
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+
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+ <!-- Begin Page Heading -->
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+ <span class="title">
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+ P450 Drug Interaction Table
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+ </span>
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+ <!-- End Page Heading -->
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+
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+ <!-- Begin Main Body Content -->
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+
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+ <hr/>
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+ <table cellpadding="2">
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+ <tr><td colspan="8"><h1>SUBSTRATES</h1></td></tr>
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+ <tr bgcolor="#CCCCCC" align="center">
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+ <td>1A2</td>
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+ <td>2B6</td>
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+ <td>2C8</td>
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+ <td>2C9</td>
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+ <td>2C19</td>
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+ <td>2D6</td>
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+ <td>2E1</td>
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+ <td>3A4,5,7</td>
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+ </tr>
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+
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+ <tr valign="top">
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+ <td>
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+ <a href="1A2references.asp#amitriptylineSub">amitriptyline</a><br />
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+ <a href="1A2references.asp#caffeineSub">caffeine</a><sup>2</sup><br />
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+ <a href="1A2references.asp#clomipramineSub">clomipramine</a><br />
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+ <a href="1A2references.asp#clozapineSub">clozapine</a><br />
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+ <a href="1A2references.asp#cyclobenzaprineSub">cyclobenzaprine</a><br />
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+ <a href="1A2references.asp#estradiolSub">estradiol</a><br />
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+ <a href="1A2references.asp#fluvoxamineSub">fluvoxamine</a><br />
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+ <a href="1A2references.asp#haloperidolSub">haloperidol</a><br />
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+ <a href="1A2references.asp#imipramineSub">imipramine N-DeMe</a><br />
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+ <a href="1A2references.asp#mexiletineSub">mexiletine</a><br />
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+ <a href="1A2references.asp#naproxenSub">naproxen</a><br />
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+ <a href="1A2references.asp#olanzapineSub">olanzapine</a><br />
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+ <a href="1A2references.asp#ondansetronSub">ondansetron</a><br />
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+ <a href="1A2references.asp#phenacetinSub">phenacetin</a><sup>1</sup>&rarr;<br />acetaminophen&rarr;NAPQI<br />
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+ <a href="1A2references.asp#propranololSub">propranolol</a><br />
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+ <a href="1A2references.asp#riluzoleSub">riluzole</a><br />
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+ <a href="1A2references.asp#ropivacaineSub">ropivacaine</a><br />
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+ <a href="1A2references.asp#tacrineSub">tacrine</a><sup>2</sup><br />
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+ <a href="1A2references.asp#theophyllineSub">theophylline</a><sup>2</sup><br />
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+ <a href="1A2references.asp#tizanidineSub">tizanidine</a><br />
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+ <a href="1A2references.asp#verapamilSub">verapamil</a><br />
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+ <a href="1A2references.asp#warfarinSub">(R)warfarin</a><br />
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+ <a href="1A2references.asp#zileutonSub">zileuton</a><br />
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+ <a href="1A2references.asp#zolmitriptanSub">zolmitriptan</a>
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+ </td>
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+
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+ <td>
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+ <a href="2B6references.asp#bupropionSub">bupropion</a><sup>1</sup><br />
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+ <a href="2B6references.asp#cyclophosphamideSub">cyclophosphamide</a><br />
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+ <a href="2B6references.asp#efavirenzSub">efavirenz</a><sup>1</sup><br />
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+ <a href="2B6references.asp#ifosphamideSub">ifosphamide</a><br />
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+ <a href="2B6references.asp#methadoneSub">methadone</a><br />
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+ <a href="2B6references.asp#sorafenibSub">sorafenib</a><br />
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+ </td>
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+
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+ <td>
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+ <a href="2C8references.asp#amodiaquineSub">amodiaquine</a><sup>2</sup><br />
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+ <a href="2C8references.asp#cerivastatinSub">cerivastatin</a><br />
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+ <a href="2C8references.asp#paclitaxelSub">paclitaxel</a><br />
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+ <a href="2C8references.asp#repaglinideSub">repaglinide</a><br />
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+ <a href="2C8references.asp#sorafenibSub">sorafenib</a><br />
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+ <a href="2C8references.asp#torsemideSub">torsemide</a><br />
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+ </td>
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+
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+ <td>
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+ <strong>NSAIDs:</strong><br />
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+ <a href="2C9references.asp#diclofenacSub">diclofenac</a><sup>1</sup><br />
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+ <a href="2C9references.asp#ibuprofenSub">ibuprofen</a><br />
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+ <a href="2C9references.asp#lornoxicamSub">lornoxicam</a><br />
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+ <a href="2C9references.asp#meloxicamSub">meloxicam</a><br />
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+ <a href="2C9references.asp#S-naproxenSub">S-naproxen&rarr;Nor</a><br />
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+ <a href="2C9references.asp#piroxicamSub">piroxicam</a><br />
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+ <a href="2C9references.asp#suprofenSub">suprofen</a><br /><br />
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+
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+ <strong>Oral Hypoglycemic Agents:</strong><br />
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+ <a href="2C9references.asp#tolbutamideSub">tolbutamide</a><sup>1</sup><br />
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+ <a href="2C9references.asp#glipizideSub">glipizide</a><br /><br />
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+
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+ <strong>Angiotensin II Blockers:</strong><br />
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+ <a href="2C9references.asp#lorsartanSub">losartan</a><br />
252
+ <a href="2C9references.asp#irbesartanSub">irbesartan</a><br /><br />
253
+
254
+ <strong>Sulfonylureas:</strong><br />
255
+ <a href="2C9references.asp#glyburideSub">glyburide</a><br />
256
+ <a href="2C9references.asp#glibenclamideSub">glibenclamide</a><br />
257
+ <a href="2C9references.asp#glipizideSub">glipizide</a><br />
258
+ <a href="2C9references.asp#glimepirideSub">glimepiride</a><br />
259
+ <a href="2C9references.asp#tolbutamideSub">tolbutamide</a><br /><br />
260
+
261
+ <a href="2C9references.asp#amitriptylineSub">amitriptyline</a><br />
262
+ <a href="2C9references.asp#celecoxibSub">celecoxib</a><br />
263
+ <a href="2C9references.asp#fluoxetineSub">fluoxetine</a><br />
264
+ <a href="2C9references.asp#fluvastatinSub">fluvastatin</a><br />
265
+ <a href="2C9references.asp#glyburideSub">glyburide</a><br />
266
+ <a href="2C9references.asp#nateglinideSub">nateglinide</a><br />
267
+ <a href="2C9references.asp#phenytoin-4Sub">phenytoin-4-OH2</a><br />
268
+ <a href="2C9references.asp#rosiglitazoneSub">rosiglitazone</a><br />
269
+ <a href="2C9references.asp#tamoxifenSub">tamoxifen</a><br />
270
+ <a href="2C9references.asp#torsemideSub">torsemide</a><br />
271
+ <a href="2C9references.asp#S-warfarinSub">S-warfarin</a><sup>1</sup>
272
+ </td>
273
+
274
+ <td>
275
+ <strong>PPIs:</strong><br />
276
+ <a href="2C19references.asp#lansoprazoleSub">lansoprazole</a><br />
277
+ <a href="2C19references.asp#omeprazoleSub">omeprazole2</a><br />
278
+ <a href="2C19references.asp#pantoprazoleSub">pantoprazole</a><br />
279
+ <a href="2C19references.asp#rabeprazoleSub">rabeprazole</a><br /><br />
280
+
281
+ <strong>Anti-epileptics:</strong><br />
282
+ <a href="2C19references.asp#diazepamSub">diazepam&rarr;Nor</a><br />
283
+ <a href="2C19references.asp#phenytoinSub">phenytoin(O)</a><br />
284
+ <a href="2C19references.asp#mephenytoinSub">S-mephenytoin</a><sup>1</sup><br />
285
+ <a href="2C19references.asp#phenobarbitoneSub">phenobarbitone</a><br /><br />
286
+
287
+ <a href="2C19references.asp#amitriptylineSub">amitriptyline</a><br />
288
+ <a href="2C19references.asp#carisoprodolSub">carisoprodol</a><br />
289
+ <a href="2C19references.asp#citalopramSub">citalopram</a><br />
290
+ <a href="2C19references.asp#chloramphenicolSub">chloramphenicol</a><br />
291
+ <a href="2C19references.asp#clomipramineSub">clomipramine</a><br />
292
+ <a href="2C19references.asp#clopidogrelSub">clopidogrel</a><br />
293
+ <a href="2C19references.asp#cyclophosphamideSub">cyclophosphamide</a><br />
294
+ <a href="2C19references.asp#hexobarbitalSub">hexobarbital</a><br />
295
+ <a href="2C19references.asp#imipramineSub">imipramine N-DeME</a><br />
296
+ <a href="2C19references.asp#indomethacinSub">indomethacin</a><br />
297
+ <a href="2C19references.asp#mephobarbitalSub">R-mephobarbital</a><br />
298
+ <a href="2C19references.asp#moclobemideSub">moclobemide</a><br />
299
+ <a href="2C19references.asp#nelfinavirSub">nelfinavir</a><br />
300
+ <a href="2C19references.asp#nilutamideSub">nilutamide</a><br />
301
+ <a href="2C19references.asp#primidoneSub">primidone</a><br />
302
+ <a href="2C19references.asp#progesteroneSub">progesterone</a><br />
303
+ <a href="2C19references.asp#proguanilSub">proguanil</a><br />
304
+ <a href="2C19references.asp#propranololSub">propranolol</a><br />
305
+ <a href="2C19references.asp#teniposideSub">teniposide</a><br />
306
+ <a href="2C19references.asp#warfarinSub">R-warfarin&rarr;8-OH</a>
307
+ </td>
308
+
309
+ <td>
310
+ <a href="2D6references.asp#tamoxifenSub">tamoxifen</a>:<br>
311
+ <strong><a href="../COBRA/Tamoxifen and 2D6v7.pdf">TAMOXIFEN GUIDE</a></strong><br /><br>
312
+
313
+ <strong>Beta Blockers:</strong><br />
314
+ <a href="2D6references.asp#carvedilolSub">carvedilol</a><br />
315
+ <a href="2D6references.asp#metoprololSub">S-metoprolol</a><br />
316
+ <a href="2D6references.asp#propafenoneSub">propafenone</a><br />
317
+ <a href="2D6references.asp#timololSub">timolol</a><br /><br />
318
+
319
+ <strong>Antidepressants:</strong><br />
320
+ <a href="2D6references.asp#amitriptylineSub">amitriptyline</a><br />
321
+ <a href="2D6references.asp#clomipramineSub">clomipramine</a><br />
322
+ <a href="2D6references.asp#desipramineSub">desipramine</a><br />
323
+ <a href="2D6references.asp#fluoxetineSub">fluoxetine</a><br />
324
+ <a href="2D6references.asp#imipramineSub">imipramine</a><br />
325
+ <a href="2D6references.asp#paroxetineSub">paroxetine</a><br /><br />
326
+
327
+ <strong>Antipsychotics:</strong><br />
328
+ <a href="2D6references.asp#haloperidolSub">haloperidol</a><br />
329
+ <a href="2D6references.asp#perphenazineSub">perphenazine</a><br />
330
+ <a href="2D6references.asp#risperidoneSub">risperidone&rarr;9-OH</a><br />
331
+ <a href="2D6references.asp#thioridazineSub">thioridazine</a><br />
332
+ <a href="2D6references.asp#zuclopenthixolSub">zuclopenthixol</a><br /><br />
333
+
334
+ <a href="2D6references.asp#alprenololSub">alprenolol</a><br />
335
+ <a href="2D6references.asp#amphetamineSub">amphetamine</a><br />
336
+ <a href="2D6references.asp#aripiprazoleSub">aripiprazole</a><br />
337
+ <a href="2D6references.asp#atomoxetineSub">atomoxetine</a><br />
338
+ <a href="2D6references.asp#bufuralolSub">bufuralol</a><sup>1</sup><br />
339
+ <a href="2D6references.asp#chlorpheniramineSub">chlorpheniramine</a><br />
340
+ <a href="2D6references.asp#chlorpromazineSub">chlorpromazine</a><br />
341
+ <a href="2D6references.asp#codeineSub">codeine (&rarr;O-desMe)</a><br />
342
+ <a href="2D6references.asp#debrisoquineSub">debrisoquine</a><sup>2</sup><br />
343
+ <a href="2D6references.asp#dexfenfluramineSub">dexfenfluramine</a><br />
344
+ <a href="2D6references.asp#dextromethorphanSub">dextromethorphan</a><sup>1</sup><br />
345
+ <a href="2D6references.asp#donepezilSub">donepezil</a><br />
346
+ <a href="2D6references.asp#duloxetineSub">duloxetine</a><br />
347
+ <a href="2D6references.asp#encainideSub">encainide</a><br />
348
+ <a href="2D6references.asp#flecainideSub">flecainide</a><br />
349
+ <a href="2D6references.asp#fluvoxamineSub">fluvoxamine</a><br />
350
+ <a href="2D6references.asp#lidocaineSub">lidocaine</a><br />
351
+ <a href="2D6references.asp#metoclopramideSub">metoclopramide</a><br />
352
+ <a href="2D6references.asp#methoxyamphetamineSub">methoxyamphetamine</a><br />
353
+ <a href="2D6references.asp#mexiletineSub">mexiletine</a><br />
354
+ <a href="2D6references.asp#minaprineSub">minaprine</a><br />
355
+ <a href="2D6references.asp#nebivololSub">nebivolol</a><br />
356
+ <a href="2D6references.asp#nortriptylineSub">nortriptyline</a><br />
357
+ <a href="2D6references.asp#ondansetronSub">ondansetron</a><br />
358
+ <a href="2D6references.asp#oxycodoneSub">oxycodone</a><br />
359
+ <a href="2D6references.asp#perhexilineSub">perhexiline</a><br />
360
+ <a href="2D6references.asp#phenacetinSub">phenacetin</a><br />
361
+ <a href="2D6references.asp#phenforminSub">phenformin</a><br />
362
+ <a href="2D6references.asp#promethazineSub">promethazine</a><br />
363
+ <a href="2D6references.asp#propranololSub">propranolol</a><br />
364
+ <a href="2D6references.asp#sparteineSub">sparteine</a><br />
365
+ <a href="2D6references.asp#tramadolSub">tramadol</a><br />
366
+ <a href="2D6references.asp#venlafaxineSub">venlafaxine</a><br />
367
+ </td>
368
+
369
+ <td>
370
+ <strong>Anesthetics:</strong><br />
371
+ <a href="2E1references.asp#enfluraneSub">enflurane</a><br />
372
+ <a href="2E1references.asp#halothaneSub">halothane</a><br />
373
+ <a href="2E1references.asp#isofluraneSub">isoflurane</a><br />
374
+ <a href="2E1references.asp#methoxyfluraneSub">methoxyflurane</a><br />
375
+ <a href="2E1references.asp#sevofluraneSub">sevoflurane</a><br /><br />
376
+
377
+ <a href="2E1references.asp#acetaminophenSub">acetaminophen&rarr;NAPQI</a><br />
378
+ <a href="2E1references.asp#anilineSub">aniline</a>2<br />
379
+ <a href="2E1references.asp#benzeneSub">benzene</a><br />
380
+ <a href="2E1references.asp#chlorzoxazoneSub">chlorzoxazone</a>1<br />
381
+ <a href="2E1references.asp#ethanolSub">ethanol</a><br />
382
+ <a href="2E1references.asp#dimethylformamideSub">N,N-dimethylformamide</a><br />
383
+ <a href="2E1references.asp#theophyllineSub">theophylline&rarr;8-OH</a>
384
+ </td>
385
+
386
+ <td>
387
+ <strong>Macrolide antibiotics:</strong><br />
388
+ <a href="3A457references.asp#clarithromycinSub">clarithromycin</a><br />
389
+ <a href="3A457references.asp#erythromycinSub">erythromycin</a><sup>2</sup> (not 3A5)<br />
390
+ <a href="3A457references.asp#azithromycinSub">NOT azithromycin</a><br />
391
+ <a href="3A457references.asp#telithromycinSub">telithromycin</a><br /><br />
392
+
393
+ <strong>Anti-arrhythmics:</strong><br />
394
+ <a href="3A457references.asp#quinidineSub">quinidine</a>&rarr;3-OH (not 3A5)<br /><br />
395
+
396
+ <strong>Benzodiazepines:</strong><br />
397
+ <a href="3A457references.asp#alprazolamSub">alprazolam</a><br />
398
+ <a href="3A457references.asp#diazepamSub">diazepam</a>&rarr;3OH<br />
399
+ <a href="3A457references.asp#midazolamSub">midazolam</a><sup>1</sup><br />
400
+ <a href="3A457references.asp#triazolamSub">triazolam</a><sup>2</sup><br /><br />
401
+
402
+ <strong>Immune Modulators:</strong><br />
403
+ <a href="3A457references.asp#cyclosporineSub">cyclosporine</a><br />
404
+ <a href="3A457references.asp#tacrolimusSub">tacrolimus</a> (FK506)<br /><br />
405
+
406
+ <strong>HIV Antivirals:</strong><br />
407
+ <a href="3A457references.asp#indinavirSub">indinavir</a><br />
408
+ <a href="3A457references.asp#nelfinavirSub">nelfinavir</a><br />
409
+ <a href="3A457references.asp#ritonavirSub">ritonavir</a><br />
410
+ <a href="3A457references.asp#saquinavirSub">saquinavir</a><br /><br />
411
+
412
+ <strong>Prokinetic:</strong><br />
413
+ <a href="3A457references.asp#cisaprideSub">cisapride</a><br /><br />
414
+
415
+ <strong>Antihistamines:</strong><br />
416
+ <a href="3A457references.asp#astemizoleSub">astemizole</a><br />
417
+ <a href="3A457references.asp#chlorpheniramineSub">chlorpheniramine</a><br />
418
+ <a href="3A457references.asp#terfenadineSub">terfenadine</a><sup>2</sup><br /><br />
419
+
420
+ <strong>Calcium Channel Blockers:</strong><br />
421
+ <a href="3A457references.asp#amlodipineSub">amlodipine</a><br />
422
+ <a href="3A457references.asp#diltiazemSub">diltiazem</a><br />
423
+ <a href="3A457references.asp#felodipineSub">felodipine</a><br />
424
+ <a href="3A457references.asp#lercanidipineSub">lercanidipine</a><br />
425
+ <a href="3A457references.asp#nifedipineSub">nifedipine</a><sup>2</sup><br />
426
+ <a href="3A457references.asp#nisoldipineSub">nisoldipine</a><br />
427
+ <a href="3A457references.asp#nitrendipineSub">nitrendipine</a><br />
428
+ <a href="3A457references.asp#verapamilSub">verapamil</a><br /><br />
429
+
430
+ <strong>HMG CoA Reductase Inhibitors:</strong><br />
431
+ <a href="3A457references.asp#atorvastatinSub">atorvastatin</a><br />
432
+ <a href="3A457references.asp#cerivastatinSub">cerivastatin </a><br />
433
+ <a href="3A457references.asp#lovastatinSub">lovastatin</a><br />
434
+ <a href="3A457references.asp#pravastatinSub">NOT pravastatin</a><br />
435
+ <a href="3A457references.asp#rosuvastatinSub">NOT rosuvastatin</a><br />
436
+ <a href="3A457references.asp#simvastatinSub">simvastatin</a><br /><br />
437
+
438
+ <strong>Steroid 6beta-OH:</strong><br />
439
+ <a href="3A457references.asp#estradiolSub">estradiol</a><br />
440
+ <a href="3A457references.asp#hydrocortisoneSub">hydrocortisone</a><br />
441
+ <a href="3A457references.asp#progesteroneSub">progesterone</a><br />
442
+ <a href="3A457references.asp#testosteroneSub">testosterone</a><sup>1</sup><br /><br />
443
+
444
+ <strong>Miscellaneous:</strong><br />
445
+ <a href="3A457references.asp#alfentanilSub">alfentanil</a><br />
446
+ <a href="3A457references.asp#aprepitantSub">aprepitant</a><br />
447
+ <a href="3A457references.asp#aripiprazoleSub">aripiprazole</a><br />
448
+ <a href="3A457references.asp#buspironeSub">buspirone</a><br />
449
+ cafergot<br />
450
+ <a href="3A457references.asp#caffeineSub">caffeine</a>&rarr;TMU<br />
451
+ <a href="3A457references.asp#cilostazolSub">cilostazol</a><br />
452
+ <a href="3A457references.asp#cocaineSub">cocaine</a><br />
453
+ <a href="3A457references.asp#codeineSub">codeine-N-demethylation</a><br />
454
+ <a href="3A457references.asp#dapsoneSub">dapsone</a><br />
455
+ <a href="3A457references.asp#dexamethasoneSub">dexamethasone</a><br />
456
+ <a href="3A457references.asp#dextromethorphanSub">dextromethorphan</a><sup>2</sup><br />
457
+ <a href="3A457references.asp#docetaxelSub">docetaxel</a><br />
458
+ <a href="3A457references.asp#domperidoneSub">domperidone</a><br />
459
+ <a href="3A457references.asp#eplerenoneSub">eplerenone</a><br />
460
+ <a href="3A457references.asp#fentanylSub">fentanyl</a><br />
461
+ <a href="3A457references.asp#finasterideSub">finasteride</a><br />
462
+ <a href="3A457references.asp#gleevecSub">gleevec</a><br />
463
+ <a href="3A457references.asp#haloperidolSub">haloperidol</a><br />
464
+ <a href="3A457references.asp#irinotecanSub">irinotecan</a><br />
465
+ <a href="3A457references.asp#methadoneSub">LAAM</a><br />
466
+ <a href="3A457references.asp#lidocaineSub">lidocaine</a><br />
467
+ <a href="3A457references.asp#methadoneSub">methadone</a><br />
468
+ <a href="3A457references.asp#nateglinideSub">nateglinide</a><br />
469
+ <a href="3A457references.asp#ondansetronSub">ondansetron</a><br />
470
+ <a href="3A457references.asp#pimozideSub">pimozide</a><br />
471
+ <a href="3A457references.asp#propranololSub">propranolol</a><br />
472
+ <a href="3A457references.asp#quetiapineSub">quetiapine</a><br />
473
+ <a href="3A457references.asp#quinineSub">quinine</a><br />
474
+ <a href="3A457references.asp#risperidoneSub">risperidone</a><br />
475
+ <a href="3A457references.asp#salmeterolSub">salmeterol</a><br />
476
+ <a href="3A457references.asp#sildenafilSub">sildenafil</a><br />
477
+ <a href="3A457references.asp#sirolimusSub">sirolimus</a><br />
478
+ <a href="3A457references.asp#sorafenibSub">sorafenib</a><br />
479
+ <a href="3A457references.asp#sunitinibSub">sunitinib</a><br />
480
+ <a href="3A457references.asp#tamoxifenSub">tamoxifen</a><br />
481
+ <a href="3A457references.asp#taxolSub">taxol</a><br />
482
+ <a href="3A457references.asp#terfenadineSub">terfenadine</a><br />
483
+ <a href="3A457references.asp#toriselSub">torisel</a><br />
484
+ <a href="3A457references.asp#trazodoneSub">trazodone</a><br />
485
+ <a href="3A457references.asp#vincristineSub">vincristine</a><br />
486
+ <a href="3A457references.asp#zaleplonSub">zaleplon</a><br />
487
+ <a href="3A457references.asp#ziprasidoneSub">ziprasidone</a><br />
488
+ <a href="3A457references.asp#zolpidemSub">zolpidem</a>
489
+ </td>
490
+ </tr>
491
+
492
+ <tr><td colspan="8"><hr /><h1>INHIBITORS</h1></td></tr>
493
+
494
+ <tr><td colspan="8">
495
+ Inhibitors compete with other drugs for a particular enzyme thus affecting the optimal level of metabolism of the substrate drug which in many cases affect the individual's response to that particular medication, e.g. making it ineffective.<br />
496
+
497
+ <p>
498
+ <img src="/images/clinpharm/red.jpg" /> A <b>Strong inhibitor</b> is one that causes a > 5-fold increase in the plasma AUC values or more than 80% decrease in clearance.<br>
499
+ <img src="/images/clinpharm/orange.jpg" /> A <b>Moderate inhibitor</b> is one that causes a > 2-fold increase in the plasma AUC values or 50-80% decrease in clearance.<br>
500
+ <img src="/images/clinpharm/green.jpg" /> A <b>Weak inhibitor</b> is one that causes a > 1.25-fold but < 2-fold increase in the plasma AUC values or 20-50% decrease in clearance.<br>
501
+ <img src="/images/clinpharm/blue.jpg" /> All other inhibitors.
502
+ </p>
503
+
504
+ <p>FDA preferred<sup>1</sup> and acceptable<sup>2</sup> <b>inhibitors</b> for in vitro experiments.*</p>
505
+
506
+
507
+ </td></tr>
508
+
509
+ <!--
510
+ <tr align="center">
511
+ <td></td>
512
+ <td></td>
513
+ <td></td>
514
+ <td></td>
515
+ <td></td>
516
+ <td style="BORDER-RIGHT: orange solid; BORDER-TOP: orange solid; BORDER-LEFT: orange solid; BORDER-BOTTOM: orange solid" width="140" height="24" bgcolor="FFFFFF" ><a href="inhibitorData.asp">Utilization of 2D6 medications and tamoxifen</a></td>
517
+ <td></td>
518
+ <td></td>
519
+ </tr>
520
+ -->
521
+
522
+ <tr bgcolor="#CCCCCC" align="center">
523
+ <td>1A2</td>
524
+ <td>2B6</td>
525
+ <td>2C8</td>
526
+ <td>2C9</td>
527
+ <td>2C19</td>
528
+ <td>2D6</td>
529
+ <td>2E1</td>
530
+ <td>3A4,5,7</td>
531
+ </tr>
532
+
533
+ <tr valign="top">
534
+ <td>
535
+ <img src="/images/clinpharm/red.jpg" /> <a href="1A2references.asp#fluvoxamineInh">fluvoxamine</a><br />
536
+ <img src="/images/clinpharm/red.jpg" /> <a href="1A2references.asp#ciprofloxacinInh">ciprofloxacin</a><br /><br />
537
+
538
+ <img src="/images/clinpharm/green.jpg" /> <a href="1A2references.asp#cimetidineInh">cimetidine</a><br /><br />
539
+
540
+ <a href="1A2references.asp#amiodaroneInh">amiodarone</a><br />
541
+ <a href="1A2references.asp#fluoroInh">fluoroquinolones</a><br />
542
+ <a href="1A2references.asp#furafyllineInh">furafylline</a><sup>1</sup><br />
543
+ <a href="1A2references.asp#interferonInh">interferon</a><br />
544
+ <a href="1A2references.asp#methoxsalenInh">methoxsalen</a><br />
545
+ <a href="1A2references.asp#mibefradilInh">mibefradil</a>
546
+ </td>
547
+
548
+ <td>
549
+ <a href="2B6references.asp#thiotepaInh">thiotepa</a><br />
550
+ <a href="2B6references.asp#ticlopidineInh">ticlopidine</a><sup>2</sup>
551
+ </td>
552
+
553
+ <td>
554
+ <img src="/images/clinpharm/red.jpg" /> <a href="2C8references.asp#gemfibrozilInh">gemfibrozil</a><sup>2</sup><br /><br />
555
+
556
+ <img src="/images/clinpharm/orange.jpg" /> <a href="2C8references.asp#trimethoprimInh">trimethoprim</a><sup>2</sup><br /><br />
557
+
558
+ <a href="2C8references.asp#glitazonesInh">glitazones</a><br />
559
+ <a href="2C8references.asp#montelukastInh">montelukast</a><sup>1</sup><br />
560
+ <a href="2C8references.asp#quercetinInh">quercetin</a><sup>1</sup>
561
+ </td>
562
+
563
+ <td>
564
+ <img src="/images/clinpharm/red.jpg" /> <a href="2C9references.asp#fluconazoleInh">fluconazole</a><sup>2</sup><br /><br />
565
+
566
+ <img src="/images/clinpharm/orange.jpg" /> <a href="2C9references.asp#amiodaroneInh">amiodarone</a><br /><br />
567
+
568
+ <a href="2C9references.asp#fenofibrateInh">fenofibrate</a><br />
569
+ <a href="2C9references.asp#fluvastatinInh">fluvastatin</a><br />
570
+ <a href="2C9references.asp#fluvoxamineInh">fluvoxamine</a><sup>2</sup><br />
571
+ <a href="2C9references.asp#isoniazidInh">isoniazid</a><br />
572
+ <a href="2C9references.asp#lovastatinInh">lovastatin</a><br />
573
+ <a href="2C9references.asp#phenylbutazoneInh">phenylbutazone</a><br />
574
+ <a href="2C9references.asp#probenicidInh">probenicid</a><br />
575
+ <a href="2C9references.asp#sertralineInh">sertraline</a><br />
576
+ <a href="2C9references.asp#sulfamethoxazoleInh">sulfamethoxazole</a><br />
577
+ <a href="2C9references.asp#sulfaphenazoleInh">sulfaphenazole</a><sup>1</sup><br />
578
+ <a href="2C9references.asp#teniposideInh">teniposide</a><br />
579
+ <a href="2C9references.asp#voriconazoleInh">voriconazole</a><br />
580
+ <a href="2C9references.asp#zafirlukastInh">zafirlukast</a>
581
+ </td>
582
+
583
+ <td>
584
+ PPIs:<br />
585
+ <a href="2C19references.asp#lansoprazoleInh">lansoprazole</a><br />
586
+ <a href="2C19references.asp#omeprazoleInh">omeprazole</a>2<br />
587
+ <a href="2C19references.asp#pantoprazoleInh">pantoprazole</a><br />
588
+ <a href="2C19references.asp#rabeprazoleInh">rabeprazole</a><br /><br />
589
+
590
+ <a href="2C19references.asp#chloramphenicolInh">chloramphenicol</a><br />
591
+ <a href="2C19references.asp#cimetidineInh">cimetidine</a><br />
592
+ <a href="2C19references.asp#felbamateInh">felbamate</a><br />
593
+ <a href="2C19references.asp#fluoxetineInh">fluoxetine</a><br />
594
+ <a href="2C19references.asp#fluvoxamineInh">fluvoxamine</a><br />
595
+ <a href="2C19references.asp#indomethacinInh">indomethacin</a><br />
596
+ <a href="2C19references.asp#ketoconazoleInh">ketoconazole</a><br />
597
+ <a href="2C19references.asp#modafinilInh">modafinil</a><br />
598
+ <a href="2C19references.asp#oxcarbazepineInh">oxcarbazepine</a><br />
599
+ <a href="2C19references.asp#probenicidInh">probenicid</a><br />
600
+ <a href="2C19references.asp#ticlopidineInh">ticlopidine</a>2<br />
601
+ <a href="2C19references.asp#topiramateInh">topiramate</a>
602
+ </td>
603
+
604
+ <td>
605
+ <img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#bupropionInh">bupropion</a><br />
606
+ <img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#cinacalcetInh">cinacalcet</a><br>
607
+
608
+ <img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#fluoxetineInh">fluoxetine</a><br />
609
+ <img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#paroxetineInh">paroxetine</a><br />
610
+ <img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#quinidineInh">quinidine</a><sup>1</sup><br /><br />
611
+
612
+ <img src="/images/clinpharm/orange.jpg" /> <a href="2D6references.asp#duloxetineInh">duloxetine</a><br />
613
+ <img src="/images/clinpharm/orange.jpg" /> <a href="2D6references.asp#sertralineInh">sertraline</a><br />
614
+ <img src="/images/clinpharm/orange.jpg" /> <a href="2D6references.asp#terbinafineInh">terbinafine</a><br /><br />
615
+
616
+ <img src="/images/clinpharm/green.jpg" /> <a href="2D6references.asp#amiodaroneInh">amiodarone</a><br />
617
+ <img src="/images/clinpharm/green.jpg" /> <a href="2D6references.asp#cimetidineInh">cimetidine</a><br /><br />
618
+
619
+ <a href="2D6references.asp#celecoxibInh">celecoxib</a><br />
620
+ chlorpheniramine<br />
621
+ chlorpromazine<br />
622
+ <a href="2D6references.asp#citalopramInh">citalopram</a><br />
623
+ clemastine<br />
624
+ <a href="2D6references.asp#clomipramineInh">clomipramine</a><br />
625
+ <a href="2D6references.asp#cocaineInh">cocaine</a><br />
626
+ diphenhydramine<br />
627
+ doxepin<br />
628
+ <a href="2D6references.asp#doxorubicinInh">doxorubicin</a><br />
629
+ <a href="2D6references.asp#escitalopramInh">escitalopram</a><br />
630
+ <a href="2D6references.asp#halofantrineInh">halofantrine</a><br />
631
+ <a href="2D6references.asp#histamineInh">histamine H1 receptor antagonists</a><br />
632
+ hydroxyzine<br />
633
+ <a href="2D6references.asp#levomepromazineInh">levomepromazine</a><br />
634
+ <a href="2D6references.asp#methadoneInh">methadone</a><br />
635
+ metoclopramide<br />
636
+ mibefradil<br />
637
+ <a href="2D6references.asp#midodrineInh">midodrine</a><br />
638
+ <a href="2D6references.asp#moclobemideInh">moclobemide</a><br />
639
+ perphenazine<br />
640
+ ranitidine<br />
641
+ <a href="2D6references.asp#haloperidolInh">reduced-haloperidol</a><br />
642
+ <a href="2D6references.asp#ritonavirInh">ritonavir</a><br />
643
+ ticlopidine<br />
644
+ tripelennamine
645
+ </td>
646
+
647
+ <td>
648
+ <a href="2E1references.asp#dithiocarbamateInh">diethyl-dithiocarbamate</a><sup>2</sup><br />
649
+ <a href="2E1references.asp#disulfiramInh">disulfiram</a>
650
+ </td>
651
+
652
+ <td>
653
+ HIV Antivirals:<br />
654
+ <img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#indinavirInh">indinavir</a><br />
655
+ <img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#nelfinavirInh">nelfinavir</a><br />
656
+ <img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#ritonavirInh">ritonavir</a><br /><br />
657
+
658
+ <img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#clarithromycinInh">clarithromycin</a><br />
659
+ <img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#itraconazoleInh">itraconazole</a><sup>1</sup><br />
660
+ <img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#ketoconazoleInh">ketoconazole</a><sup>1</sup><br />
661
+ <img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#nefazodoneInh">nefazodone</a><br />
662
+ <img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#saquinavirInh">saquinavir</a><br />
663
+ <img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#telithromycinInh">telithromycin</a><br /><br />
664
+
665
+ <img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#aprepitantInh">aprepitant</a><br />
666
+ <img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#erythromycinInh">erythromycin</a><br />
667
+ <img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#fluconazoleInh">fluconazole</a><br />
668
+ <img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#grapefruitInh">grapefruit juice</a><br />
669
+ <img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#verapamilInh">verapamil</a><sup>2</sup><br />
670
+ <img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#diltiazemInh">diltiazem</a><br /><br />
671
+
672
+ <img src="/images/clinpharm/green.jpg" /> <a href="3A457references.asp#cimetidineInh">cimetidine</a><br /><br />
673
+
674
+ <a href="3A457references.asp#amiodaroneInh">amiodarone</a><br />
675
+ <a href="3A457references.asp#azithromycinInh">NOT azithromycin</a><br />
676
+ chloramphenicol<br />
677
+ <a href="3A457references.asp#ciprofloxacinInh">ciprofloxacin</a><br />
678
+ <a href="3A457references.asp#delaviridineInh">delaviridine</a><br /><br />
679
+ <a href="3A457references.asp#dithiocarbamateInh">diethyl-dithiocarbamate</a><br />
680
+ <a href="3A457references.asp#fluvoxamineInh">fluvoxamine</a><br />
681
+ <a href="3A457references.asp#gestodeneInh">gestodene</a><br />
682
+ <a href="3A457references.asp#imatinibInh">imatinib</a><br />
683
+ <a href="3A457references.asp#mibefradilInh">mibefradil</a><br />
684
+ <a href="3A457references.asp#mifepristoneInh">mifepristone</a><br />
685
+ <a href="3A457references.asp#norfloxacinInh">norfloxacin</a><br />
686
+ <a href="3A457references.asp#norfluoxetineInh">norfluoxetine</a><br />
687
+ <a href="3A457references.asp#starfruitInh">starfruit</a><br />
688
+ <a href="3A457references.asp#voriconazoleInh">voriconazole</a>
689
+ </td>
690
+ </tr>
691
+
692
+ <tr><td colspan="8"><hr /><h1>INDUCERS</h1></td></tr>
693
+
694
+ <tr bgcolor="#CCCCCC" align="center">
695
+ <td>1A2</td>
696
+ <td>2B6</td>
697
+ <td>2C8</td>
698
+ <td>2C9</td>
699
+ <td>2C19</td>
700
+ <td>2D6</td>
701
+ <td>2E1</td>
702
+ <td>3A4,5,7</td>
703
+ </tr>
704
+
705
+ <tr valign="top">
706
+
707
+ <td>
708
+ <a href="1A2references.asp#broccoliInd">broccoli</a><br />
709
+ <a href="1A2references.asp#brusselInd">brussel sprouts</a><br />
710
+ <a href="1A2references.asp#charInd">char-grilled meat</a><br />
711
+ <a href="1A2references.asp#insulinInd">insulin</a><br />
712
+ <a href="1A2references.asp#methylInd">methylcholanthrene</a><sup>1</sup><br />
713
+ <a href="1A2references.asp#modafinilInd">modafinil</a><br />
714
+ <a href="1A2references.asp#nafcillinInd">nafcillin</a><br />
715
+ <a href="1A2references.asp#betaInd">beta-naphthoflavone</a><sup>1</sup><br />
716
+ <a href="1A2references.asp#omeprazoleInd">omeprazole</a><sup>1</sup><br />
717
+ <a href="1A2references.asp#tobaccoInd">tobacco</a><br />
718
+ </td>
719
+
720
+ <td>
721
+ <a href="2B6references.asp#phenobarbitalInd">phenobarbital</a><br />
722
+ <a href="2B6references.asp#phenytoinInd">phenytoin</a><br />
723
+ <a href="2B6references.asp#rifampinInd">rifampin</a>
724
+ </td>
725
+
726
+ <td>
727
+ <a href="2C8references.asp#rifampicinInd">rifampin</a><sup>1</sup>
728
+ </td>
729
+
730
+ <td>
731
+ <a href="2C9references.asp#rifampinInd">rifampin</a><br />
732
+ <a href="2C9references.asp#secobarbitalInd">secobarbital</a>
733
+ </td>
734
+
735
+ <td>
736
+ <a href="2C19references.asp#carbamazepineInd">carbamazepine</a><br />
737
+ <a href="2C19references.asp#norethindroneInd">norethindrone</a><br />
738
+ <a href="2C19references.asp#pentobarbitalInd">NOT pentobarbital</a><br />
739
+ <a href="2C19references.asp#prednisoneInd">prednisone</a><br />
740
+ <a href="2C19references.asp#rifampicinInd">rifampicin</a><sup>1</sup>
741
+ </td>
742
+
743
+ <td>
744
+ <a href="2D6references.asp#dexamethasoneInd">dexamethasone</a><br />
745
+ <a href="2D6references.asp#rifampinInd">rifampin</a><br />
746
+
747
+
748
+ </td>
749
+
750
+ <td>
751
+ <a href="2E1references.asp#ethanolInd">ethanol</a><br />
752
+ <a href="2E1references.asp#isoniazidInd">isoniazid</a>
753
+ </td>
754
+
755
+
756
+ <td>
757
+ HIV Antivirals:<br />
758
+ <a href="3A457references.asp#efavirenzInd">efavirenz</a><br />
759
+ <a href="3A457references.asp#nevirapineInd">nevirapine</a><br /><br />
760
+
761
+ <a href="3A457references.asp#barbituratesInd">barbiturates</a><br />
762
+ <a href="3A457references.asp#carbamazepineInd">carbamazepine</a><br />
763
+ <a href="3A457references.asp#glucocorticoidsInd">glucocorticoids</a><br />
764
+ <a href="3A457references.asp#modafinilInd">modafinil</a><br />
765
+ <a href="3A457references.asp#oxcarbazepineInd">oxcarbazepine</a><br />
766
+ <a href="3A457references.asp#phenobarbitalInd">phenobarbital</a><sup>2</sup><br />
767
+ <a href="3A457references.asp#phenytoinInd">phenytoin</a><sup>2</sup><br />
768
+ <a href="3A457references.asp#pioglitazoneInd">pioglitazone</a><br />
769
+ <a href="3A457references.asp#rifabutinInd">rifabutin</a><br />
770
+ <a href="3A457references.asp#rifampinInd">rifampin</a><sup>1</sup><br />
771
+ <a href="3A457references.asp#stjohnswortInd">St. John's wort</a><br />
772
+ <a href="3A457references.asp#troglitazone1Ind">troglitazone</a><sup>1</sup>
773
+ </td>
774
+ </tr>
775
+ </table>
776
+
777
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778
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779
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780
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781
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782
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783
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784
+ </div>
785
+
786
+ <div class="footer_levelone">
787
+ <a href="http://www.indiana.edu" target="_blank">IU</a> |
788
+ <a href="http://www.iupui.edu" target="_blank">IUPUI</a> |
789
+ <a href="http://medicine.iu.edu/body.cfm?id=335">Disclaimer</a> |
790
+ <a href="http://medicine.iu.edu/body.cfm?id=336">Privacy Policy</a> |
791
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792
+
793
+ <a href="http://www.indiana.edu/comments/copyright.shtml" target="_blank">Copyright 2009</a>, The Trustees of Indiana University |
794
+ <a href="http://www.indiana.edu/comments/complaint.shtml" target="_blank">Copyright Complaints</a><br/>
795
+
796
+ Last Updated On: March 03, 2010<br/>
797
+
798
+ 1001 W. 10th Street, WD W7123 | Indianapolis, IN 46202 | Phone: (317) 630-8795 | Fax: (317) 630-8185
799
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800
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801
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802
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803
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804
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805
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806
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807
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808
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809
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810
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811
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812
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813
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814
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815
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817
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818
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819
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820
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