oddb.org 1.0.0 → 1.0.1

data/lib/oddb.org.rb

@@ -1,3 +1,3 @@
 class Oddb.org
-  VERSION = '1.0.0'
+  VERSION = '1.0.1'
 end

data/src/model/package.rb

@@ -109,7 +109,8 @@ module ODDB
         pack != self \
           && (other = pack.comparable_size) \
           && bottom < other \
-          && top > other
+          && top > other \
+          && !pack.basename.nil?
       rescue RuntimeError => e
         false
       end
@@ -130,7 +131,7 @@ module ODDB
       comparables.uniq
     end
     def comparable_size
-      @parts.collect { |part| part.comparable_size }.inject { |a, b| a + b }
+      @parts.collect { |part| part.comparable_size }.inject{ |a, b| a + b } or raise RuntimeError
     rescue RuntimeError
       @parts.inject(Dose.new(0)) { |comp, part|
         ODDB::Dose.new(comp.qty + part.comparable_size.qty)

data/src/plugin/analysis.rb

@@ -1,6 +1,8 @@
 #!/usr/bin/env ruby
 #  AnalysisPlugin -- oddb.org -- 09.06.2006 -- sfrischknecht@ywesee.com
 
+$: << path = File.expand_path("../..", File.dirname(__FILE__)) unless $:.include?(path)
+
 require 'plugin/plugin'
 require 'ext/analysisparse/src/analysis_hpricot'
 require 'model/analysis/group'

data/src/plugin/bsv_xml.rb

@@ -482,7 +482,7 @@ module ODDB
             @ikscd = '%03i' % @text[-3,3].to_i
             @pack ||= @registration.package @ikscd
             if !@pcode.empty? && @pack && @pack.pharmacode \
-              && @pack.pharmacode != @pcode
+              && @pack.pharmacode != @pcode && @pack.pharmacode.to_i != 0
               @report.store :pharmacode_oddb, @pack.pharmacode
               @conflict = true
             end

data/src/plugin/hospitals.rb

@@ -1,6 +1,7 @@
 #!/usr/bin/env ruby
 # HospitalPlugin -- oddb -- 07.02.2005 -- jlang@ywesee.com
 
+$: << File.expand_path('../..', File.dirname(__FILE__))
 $: << File.expand_path('../../src', File.dirname(__FILE__))
 
 require 'plugin/plugin'

data/src/plugin/oddbdat_export.rb

@@ -47,7 +47,14 @@ class OddbDatExport < ODDB::Plugin
 			LimTxtTable, EanTable
 		]
 		ids = []
-		@app.each_package { |pac| ids.push(pac.odba_id) }
+        dose_missing_list = []
+		@app.each_package { |pac| 
+          ids.push(pac.odba_id) 
+          if pac.parts.empty?
+            dose_missing_list.push([pac.basename, pac.iksnr, pac.sequence.seqnr, pac.ikscd])
+          end
+        }
+
 		files += EXPORT_SERVER.export_oddbdat(ids, EXPORT_DIR, package_tables)
 
 		# codes table
@@ -65,9 +72,12 @@ class OddbDatExport < ODDB::Plugin
 
 		# readme
 		files += EXPORT_SERVER.export_oddbdat(nil, EXPORT_DIR, [Readme])
-		
+
 		# compress
 		EXPORT_SERVER.compress_many(EXPORT_DIR, 'oddbdat', files)
+
+        # warning
+        return dose_missing_list
 	end
 	def export_fachinfos
 		# fachinfo table

data/src/plugin/text_info.rb

@@ -97,23 +97,17 @@ module ODDB
     rescue
       []
     end
-    def extract_fachinfo_id href
-      fi_ptrn = /Monographie.aspx\?Id=([0-9A-Fa-f\-]{36}).*MonType=fi/u
-      if match = fi_ptrn.match(href.to_s)
-        match[1]
-      end
-    end
     def fachinfo_news agent=init_agent
       url = ODDB.config.text_info_newssource \
         or raise 'please configure ODDB.config.text_info_newssource to proceed'
-      ids = []
+      name_list = []
       page = agent.get url
-      page.links.each do |link|
-        if id = extract_fachinfo_id(link.href)
-          ids.push [id, link.text.gsub(/;$/, '')]
-        end
+      list = page.at('div[id="blockContentInner"]/p')
+      list.to_html.split("\<br\>").each do |element|
+        name = element.delete("\<p\>").delete("\<\/p\>").chomp.strip
+        name_list << name
       end
-      ids
+      return name_list.sort
     end
     def identify_eventtargets page, ptrn
       eventtargets = {}
@@ -161,15 +155,13 @@ module ODDB
     end
     def import_news agent=init_agent
       old_news = old_fachinfo_news
-      updates = true_news fachinfo_news(agent), old_news
-      updates.reverse!
-      indices, names = updates.transpose
-      if names
-        import_name names, agent
-        log_news updates + old_news
+      news = fachinfo_news(agent)
+      if update_name_list = true_news(news, old_news)
+        import_name(update_name_list, agent)
+        log_news news
         postprocess
       end
-      !updates.empty?
+      return !update_name_list.empty?
     end
     def import_products page, agent
       fi_sources = identify_eventtargets page, /dtgFachinfo/
@@ -187,16 +179,15 @@ module ODDB
       update_product name, fi_paths, pi_paths || {}, fi_flags, pi_flags || {}
     end
     def log_news lines
-      File.open @news_log, 'w' do |fh|
-        lines.each do |pair|
-          fh.puts pair.join(' ')
-        end
+      FileUtils.mkdir_p(File.dirname(@news_log))
+      File.open(@news_log, 'w') do |fh|
+        fh.print lines.join("\n")
       end
     end
     def old_fachinfo_news
       begin
         File.readlines(@news_log).collect do |line|
-          line.strip.split ' ', 2
+          line.strip
         end
       rescue Errno::ENOENT
         []
@@ -327,11 +318,7 @@ module ODDB
       end
     end
     def true_news news, old_news
-      if (pair = old_news.first) && idx = news.flatten.index(pair.first)
-        news[0...idx/2]
-      else
-        news
-      end
+      news - old_news
     end
     def update_product name, fi_paths, pi_paths, fi_flags={}, pi_flags={}
       # parse pi and fi

data/src/util/exporter.rb

@@ -10,6 +10,7 @@ require 'plugin/fachinfo_invoicer'
 require 'plugin/download_invoicer'
 require 'plugin/ouwerkerk'
 require 'plugin/xls_export'
+require 'plugin/swissmedic'
 require 'util/log'
 require 'util/logfile'
 require 'util/schedule'
@@ -53,9 +54,11 @@ module ODDB
       export_doc_csv
       export_index_therapeuticus_csv
       export_price_history_csv
+=begin # inoperable atm.
       run_on_monthday(1) {
         export_fachinfo_pdf
       }
+=end
       nil
     end
     def export_helper(name)
@@ -145,9 +148,10 @@ module ODDB
 			sleep(30)
 		end
 		def export_oddbdat
+          dose_missing_list = []
       safe_export 'oddbdat' do
         exporter = OdbaExporter::OddbDatExport.new(@app)
-        exporter.export
+        dose_missing_list = exporter.export
         EXPORT_SERVER.clear
         sleep(30)
         run_on_weekday(1) {
@@ -155,6 +159,22 @@ module ODDB
           EXPORT_SERVER.clear
           sleep(30)
         }
+
+        # here to raise warning if package.parts is empty
+        if !dose_missing_list.empty?
+			log = Log.new(@@today)
+			log.report = [
+				"Warning: Dose data (ODDB::Package.parts, Array of ODDB::Dose instances) is empty.",
+				"Message: export_oddbdat succeeded but the following package(s) do not have Dose data.",
+				"Package(s):",
+                dose_missing_list.collect do |list|
+                  list[0].to_s + ", " + \
+                  "http://#{SERVER_NAME}/de/gcc/resolve/pointer/%3A!registration%2C" + list[1].to_s + \
+                  "!sequence%2C" + list[2].to_s + "!package%2C" + list[3].to_s + ".\n"
+                end
+			].join("\n")
+			log.notify("Warning Export: oddbdat")
+        end
       end
 		end
 		def export_pdf

data/src/util/log.rb

@@ -74,6 +74,9 @@ module ODDB
       if reply_to
         outgoing.reply_to = reply_to
       end
+      LogFile.append('oddb/debug', " @recipients=" + @recipients.inspect.to_s, Time.now)
+      LogFile.append('oddb/debug', " self::class::MAIL_TO=" + self::class::MAIL_TO.to_s, Time.now)
+      LogFile.append('oddb/debug', " self::class=" + self::class.to_s, Time.now)
 			@recipients = (@recipients + self::class::MAIL_TO).uniq
 			outgoing.subject = subj
 			outgoing.date = Time.now

data/src/util/oddbapp.rb

@@ -1484,7 +1484,7 @@ module ODDB
       update itp.creator, :text => filename, :price => price, :time => Time.now,
                           :type => :download, :expiry_time => expires,
                           :duration => (Time.now - expires) / 86400,
-                          :vat_rate => 7.6
+                          :vat_rate => 8.0
       inv.payment_received!
       inv.odba_store
       "http://#{SERVER_NAME}/de/gcc/download/invoice/#{inv.oid}/email/#{email}/filename/#{filename}"

data/src/util/oddbconfig.rb

@@ -158,7 +158,7 @@ module ODDB
 		30	=>	50,
 		365	=>	400,
 	}
-	VAT_RATE = 7.6
+	VAT_RATE = 8.0
   RSS_PATH = File.join(PROJECT_ROOT, 'data', 'rss')
 end
 

data/src/util/updater.rb

@@ -242,6 +242,7 @@ module ODDB
 			klass = BsvXmlPlugin
 			plug = klass.new(@app)
 			subj = 'SL-Update (XML)'
+            return_value_plug_update = nil
 			wrap_update(klass, subj) { 
 
         return_value_plug_update = plug.update
@@ -252,6 +253,7 @@ module ODDB
 					log_notify_bsv(plug, this_month, subj)
 				end
 			}
+            return return_value_plug_update
 		end
     def update_bsv_followers
 
@@ -334,14 +336,17 @@ module ODDB
       logs = @app.create(logs_pointer)
       klass = SwissmedicPlugin
       plug = klass.new(@app)
+      return_value_plug_update = nil
       wrap_update(klass, "swissmedic") { 
-        if(plug.update(*args))
+        #if(plug.update(*args))
+        if(return_value_plug_update = plug.update(*args))
           month = @@today << 1
           pointer = logs.pointer + [:log, Date.new(month.year, month.month)]
           log = @app.update(pointer.creator, log_info(plug))
           log.notify('Swissmedic XLS')
         end
       }
+      return return_value_plug_update
     end
     def update_swissmedic_followers
 			update_trade_status
@@ -426,12 +431,15 @@ module ODDB
       LogFile.append('oddb/debug', " after @app.update", Time.now)
 			#log.notify(subj)
       return_value_log_notify = log.notify(subj)
+      LogFile.append('oddb/debug', " the first log.notify end", Time.now)
       LogFile.append('oddb/debug', " return_value_log_notify = " + return_value_log_notify.inspect.to_s, Time.now)
 
       log2 = Log.new(date)
       log2.update_values log_info(plug, :log_info_bsv)
 
+      LogFile.append('oddb/debug', " before the second mail process", Time.now)
       return_value_log2_notify = log2.notify(subj)
+      LogFile.append('oddb/debug', " the second log.notify end", Time.now)
       LogFile.append('oddb/debug', " return_value_log2_notify = " + return_value_log2_notify.inspect.to_s, Time.now)
       #log2.notify(subj)
       return_value_log2_notify

data/test/data/html/interaction/flockhart/prepared_table.asp

@@ -0,0 +1,820 @@
+<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN">
+<html>
+<head>
+
+<title>Division of Clinical Pharmacology | Indiana University Department of Medicine</title>
+
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta name="description" content="">
+<meta name="keywords" content="">
+    
+
+
+<!-- Begin External Style Sheet Calls, based on browser -->
+	<style type="text/css" media="screen">
+		@import url(/css_stylesheets/IUSM/body.css);
+	</style>
+	<style type="text/css" media="print">
+		@import url(/css_stylesheets/IUSM/print.css);
+	</style>
+	<!--[if IE 8]>
+		<style type="text/css">
+			@import url(/css_stylesheets/IUSM/body_ie.css);
+		</style>
+		<style type="text/css" media="print">
+			@import url(/css_stylesheets/IUSM/print.css);
+		</style>
+	<![endif]-->
+	<!--[if IE 7]>
+		<style type="text/css">
+			@import url(/css_stylesheets/IUSM/body_ie.css);
+		</style>
+		<style type="text/css" media="print">
+			@import url(/css_stylesheets/IUSM/print.css);
+		</style>
+	<![endif]-->
+	<!--[if lt IE 7.]>
+		<style type="text/css">
+			@import url(/css_stylesheets/IUSM/body_ie.css);
+			@import url(/css_stylesheets/IUSM/body_ie6.css);
+		</style>
+		<style type="text/css" media="print">
+			@import url(/css_stylesheets/IUSM/print.css);
+		</style>
+	<![endif]-->
+<!-- End External Style Sheet Calls, based on browser -->
+
+
+</head>
+
+<style>
+	td {
+		font-size: 10px;
+	}
+</style>
+
+<body>
+
+<!-- Begin Standard IU Banner and Search -->
+<div id="header_span">
+	<div class="header">
+
+		<a href="http://www.indiana.edu">
+		<img src="/images/Template/iu_logo.jpg" align="left" border="0" title="Indiana University">
+		</a>
+
+		<form method="get" action="http://search2.iu.edu/search" style="padding:0px; margin:0px;">
+		<input type="hidden" name="client" value="medicine"/>
+		<input type="hidden" name="proxystylesheet" value="medicine"/>
+		<input type="hidden" name="output" value="xml_no_dtd"/>
+		<table border="0" cellpadding="0" cellspacing="0" align="right" style="width:1px; padding-top:2px; padding-bottom:2px;">
+			<tr>
+
+				<!-- Find People - optional, removed
+                <td align="left" valign="middle" ><a href="http://medicine.iu.edu/body.cfm?id=1816"><img src="/images/Template/people-search.jpg" title="Find People" border="0" style="margin-top:4px;"></a></td>
+				<td style="color:#FFFFFF; font-family:Verdana; font-size:10px;">&nbsp;&nbsp;|&nbsp; </td>
+                -->
+
+				<td align="left" valign="middle" style="width:1px;"><input type="radio" name="site" value="medicine" checked/></td>
+				<td align="left" valign="middle" style="width:1px;color:#FFFFFF; font-family:Verdana; font-size:10px;">IUSM</td>
+				<td align="left" valign="middle" style="width:1px;"><input type="radio" name="site" value="indiana" /></td>
+				<td align="left" valign="middle" style="width:1px;color:#FFFFFF; font-family:Verdana; font-size:10px;">IU</td>
+				<td align="left" valign="middle" style="width:1px;padding-left:10px;color:#000000; font-family:Verdana; font-size:10px;">
+				<input type="text" name="q" size="15" maxlength="255" value="search..." onFocus="this.value=''" class="search"/></td>
+				<td align="left" valign="middle" style="width:1px; font-weight:bold; font-family:Verdana; font-size:10px;">
+				<input type="image" src="/images/Template/searchgo.jpg" name="btnG" value="Search" class="searchgo"/></td>
+			</tr>
+		</table>
+		</form>
+	</div>
+</div>
+
+<!-- End Standard IU Banner and Search -->
+        
+<!-- Begin Standard IUSM Banner -->
+<div class="iusm_banner_span">
+	<div class="iusm_banner">
+		<a href="http://medicine.iu.edu">
+    		<img src="/images/Template/IUSM_banner.jpg" align="left" border="0" title="IU School of Medicine">
+   		</a>
+		<a href="/">
+   			<img src="/images/Template/DoM_banner.jpg" align="left" border="0" title="IU Department of Medicine">
+   		</a>
+	</div>
+</div>
+<!-- End Standard IUSM Banner -->
+
+<!-- Begin Standard Department/Division/Office/Entity Banner -->
+<div id="banner_span">
+	<div class="shadow_box">
+		<div class="banner">
+			<a href="/"><img src="/images/clinpharm/banner.jpg" border="0" align="left"></a>  
+		</div>
+	</div>
+</div>
+<!-- End Standard Department/Division/Office/Entity Banner -->  
+
+<!-- Begin Standard Horzontal Nav Bar | Nav Styles moved to an external style sheet --> 
+<div class="hornav_span">
+	<div class="hornav_shadow">
+		<div class="hornav">
+			<div class="hornav_buttons">
+         		
+	<!-- Begin Horizontal Nav Bar CSS -->
+	<style type="text/css">
+		@import url(/css_stylesheets/IUSM/top_nav.css);
+	</style>
+	<!-- End Horizontal Nav Bar CSS -->
+         	
+	<!-- Begin Horizontal Nav Bar Content -->
+	<table  border="0" cellspacing="0" cellpadding="0">
+		<tr>
+			<td valign="middle" align="right"><a class="NavBarNum1" href="/clinpharm/donations/">Make a Donation</a></td>
+<td valign="middle" align="right">&nbsp;|&nbsp;</td>
+<td valign="middle" align="right"><a class="NavBarNum1" href="/">Department of Medicine</a></td>
+		</tr>
+	</table>
+	<!-- End Horizontal Nav Bar Content -->
+
+			</div>
+		</div>
+	</div>
+</div>
+<!-- End Standard Horzontal Nav Bar -->
+    
+<!-- Begin Main Body -->    
+<div class="shadow_box">
+	<div class="content_inner">
+
+	<!-- Begin Main Body -->  
+
+	<div class='content' style='width:920px; margin-left:0px; border-left:none;'>
+
+	<!-- Begin Breadcrumbs and Back Button -->
+			<div class="breadcrumbs">
+				<div style="font-weight:normal; color:#990000; font-size:10px; float:left">
+				<script language="javascript" src="/includes/clinpharm/breadcrumb.js"></script>
+				</div>
+
+				<div style="margin-right:0px; text-align:right;">
+					<img src="/images/Template/back_go.gif" title="back" style="margin-bottom:1px;"/>
+				<a style="font-weight:normal; color:#990000; font-size:10px; cursor:pointer" 
+					onClick="javascript:history.go(-1);">BACK</a><br><br>
+				</div>
+			</div>
+			<div style="clear:both"></div>
+	<!-- End Breadcrumbs and Back Button -->
+
+	<!-- Begin Page Heading -->
+    <span class="title">
+P450 Drug Interaction Table
+    </span>
+	<!-- End Page Heading -->
+
+	<!-- Begin Main Body Content --> 
+
+<hr/>
+<table cellpadding="2">
+<tr><td colspan="8"><h1>SUBSTRATES</h1></td></tr>
+<tr bgcolor="#CCCCCC" align="center">
+<td>1A2</td>
+<td>2B6</td>
+<td>2C8</td>
+<td>2C9</td>
+<td>2C19</td>
+<td>2D6</td>
+<td>2E1</td>
+<td>3A4,5,7</td>
+</tr>
+
+<tr valign="top">
+<td>
+<a href="1A2references.asp#amitriptylineSub">amitriptyline</a><br />
+<a href="1A2references.asp#caffeineSub">caffeine</a><sup>2</sup><br />
+<a href="1A2references.asp#clomipramineSub">clomipramine</a><br />
+<a href="1A2references.asp#clozapineSub">clozapine</a><br />
+<a href="1A2references.asp#cyclobenzaprineSub">cyclobenzaprine</a><br />
+<a href="1A2references.asp#estradiolSub">estradiol</a><br />
+<a href="1A2references.asp#fluvoxamineSub">fluvoxamine</a><br />
+<a href="1A2references.asp#haloperidolSub">haloperidol</a><br />
+<a href="1A2references.asp#imipramineSub">imipramine N-DeMe</a><br />
+<a href="1A2references.asp#mexiletineSub">mexiletine</a><br />
+<a href="1A2references.asp#naproxenSub">naproxen</a><br /> 
+<a href="1A2references.asp#olanzapineSub">olanzapine</a><br />
+<a href="1A2references.asp#ondansetronSub">ondansetron</a><br /> 
+<a href="1A2references.asp#phenacetinSub">phenacetin</a><sup>1</sup>&rarr;<br />acetaminophen&rarr;NAPQI<br />
+<a href="1A2references.asp#propranololSub">propranolol</a><br />
+<a href="1A2references.asp#riluzoleSub">riluzole</a><br />
+<a href="1A2references.asp#ropivacaineSub">ropivacaine</a><br />
+<a href="1A2references.asp#tacrineSub">tacrine</a><sup>2</sup><br />
+<a href="1A2references.asp#theophyllineSub">theophylline</a><sup>2</sup><br />
+<a href="1A2references.asp#tizanidineSub">tizanidine</a><br />
+<a href="1A2references.asp#verapamilSub">verapamil</a><br />
+<a href="1A2references.asp#warfarinSub">(R)warfarin</a><br />
+<a href="1A2references.asp#zileutonSub">zileuton</a><br />
+<a href="1A2references.asp#zolmitriptanSub">zolmitriptan</a>
+</td>
+
+<td>
+<a href="2B6references.asp#bupropionSub">bupropion</a><sup>1</sup><br />
+<a href="2B6references.asp#cyclophosphamideSub">cyclophosphamide</a><br />
+<a href="2B6references.asp#efavirenzSub">efavirenz</a><sup>1</sup><br />
+<a href="2B6references.asp#ifosphamideSub">ifosphamide</a><br />
+<a href="2B6references.asp#methadoneSub">methadone</a><br />
+<a href="2B6references.asp#sorafenibSub">sorafenib</a><br />
+</td>
+
+<td>
+<a href="2C8references.asp#amodiaquineSub">amodiaquine</a><sup>2</sup><br />
+<a href="2C8references.asp#cerivastatinSub">cerivastatin</a><br />
+<a href="2C8references.asp#paclitaxelSub">paclitaxel</a><br />
+<a href="2C8references.asp#repaglinideSub">repaglinide</a><br />
+<a href="2C8references.asp#sorafenibSub">sorafenib</a><br />
+<a href="2C8references.asp#torsemideSub">torsemide</a><br />
+</td>
+
+<td>
+<strong>NSAIDs:</strong><br />
+<a href="2C9references.asp#diclofenacSub">diclofenac</a><sup>1</sup><br />
+<a href="2C9references.asp#ibuprofenSub">ibuprofen</a><br />
+<a href="2C9references.asp#lornoxicamSub">lornoxicam</a><br />
+<a href="2C9references.asp#meloxicamSub">meloxicam</a><br />
+<a href="2C9references.asp#S-naproxenSub">S-naproxen&rarr;Nor</a><br />
+<a href="2C9references.asp#piroxicamSub">piroxicam</a><br />
+<a href="2C9references.asp#suprofenSub">suprofen</a><br /><br />
+
+<strong>Oral Hypoglycemic Agents:</strong><br />
+<a href="2C9references.asp#tolbutamideSub">tolbutamide</a><sup>1</sup><br />
+<a href="2C9references.asp#glipizideSub">glipizide</a><br /><br />
+
+<strong>Angiotensin II Blockers:</strong><br />
+<a href="2C9references.asp#lorsartanSub">losartan</a><br />
+<a href="2C9references.asp#irbesartanSub">irbesartan</a><br /><br />
+
+<strong>Sulfonylureas:</strong><br />
+<a href="2C9references.asp#glyburideSub">glyburide</a><br />
+<a href="2C9references.asp#glibenclamideSub">glibenclamide</a><br />
+<a href="2C9references.asp#glipizideSub">glipizide</a><br />
+<a href="2C9references.asp#glimepirideSub">glimepiride</a><br />
+<a href="2C9references.asp#tolbutamideSub">tolbutamide</a><br /><br />
+
+<a href="2C9references.asp#amitriptylineSub">amitriptyline</a><br />
+<a href="2C9references.asp#celecoxibSub">celecoxib</a><br />
+<a href="2C9references.asp#fluoxetineSub">fluoxetine</a><br />
+<a href="2C9references.asp#fluvastatinSub">fluvastatin</a><br />
+<a href="2C9references.asp#glyburideSub">glyburide</a><br />
+<a href="2C9references.asp#nateglinideSub">nateglinide</a><br />
+<a href="2C9references.asp#phenytoin-4Sub">phenytoin-4-OH2</a><br />
+<a href="2C9references.asp#rosiglitazoneSub">rosiglitazone</a><br />
+<a href="2C9references.asp#tamoxifenSub">tamoxifen</a><br />
+<a href="2C9references.asp#torsemideSub">torsemide</a><br />
+<a href="2C9references.asp#S-warfarinSub">S-warfarin</a><sup>1</sup>
+</td>
+
+<td>
+<strong>PPIs:</strong><br />
+<a href="2C19references.asp#lansoprazoleSub">lansoprazole</a><br />
+<a href="2C19references.asp#omeprazoleSub">omeprazole2</a><br />
+<a href="2C19references.asp#pantoprazoleSub">pantoprazole</a><br />
+<a href="2C19references.asp#rabeprazoleSub">rabeprazole</a><br /><br />
+
+<strong>Anti-epileptics:</strong><br />
+<a href="2C19references.asp#diazepamSub">diazepam&rarr;Nor</a><br />
+<a href="2C19references.asp#phenytoinSub">phenytoin(O)</a><br />
+<a href="2C19references.asp#mephenytoinSub">S-mephenytoin</a><sup>1</sup><br />
+<a href="2C19references.asp#phenobarbitoneSub">phenobarbitone</a><br /><br />
+
+<a href="2C19references.asp#amitriptylineSub">amitriptyline</a><br />
+<a href="2C19references.asp#carisoprodolSub">carisoprodol</a><br />
+<a href="2C19references.asp#citalopramSub">citalopram</a><br />
+<a href="2C19references.asp#chloramphenicolSub">chloramphenicol</a><br />
+<a href="2C19references.asp#clomipramineSub">clomipramine</a><br />
+<a href="2C19references.asp#clopidogrelSub">clopidogrel</a><br />
+<a href="2C19references.asp#cyclophosphamideSub">cyclophosphamide</a><br />
+<a href="2C19references.asp#hexobarbitalSub">hexobarbital</a><br />
+<a href="2C19references.asp#imipramineSub">imipramine N-DeME</a><br />
+<a href="2C19references.asp#indomethacinSub">indomethacin</a><br />
+<a href="2C19references.asp#mephobarbitalSub">R-mephobarbital</a><br />
+<a href="2C19references.asp#moclobemideSub">moclobemide</a><br />
+<a href="2C19references.asp#nelfinavirSub">nelfinavir</a><br />
+<a href="2C19references.asp#nilutamideSub">nilutamide</a><br />
+<a href="2C19references.asp#primidoneSub">primidone</a><br />
+<a href="2C19references.asp#progesteroneSub">progesterone</a><br />
+<a href="2C19references.asp#proguanilSub">proguanil</a><br />
+<a href="2C19references.asp#propranololSub">propranolol</a><br /> 
+<a href="2C19references.asp#teniposideSub">teniposide</a><br />
+<a href="2C19references.asp#warfarinSub">R-warfarin&rarr;8-OH</a>
+</td>
+
+<td>
+<a href="2D6references.asp#tamoxifenSub">tamoxifen</a>:<br>
+<strong><a href="../COBRA/Tamoxifen and 2D6v7.pdf">TAMOXIFEN GUIDE</a></strong><br /><br>
+
+<strong>Beta Blockers:</strong><br />
+<a href="2D6references.asp#carvedilolSub">carvedilol</a><br />
+<a href="2D6references.asp#metoprololSub">S-metoprolol</a><br />
+<a href="2D6references.asp#propafenoneSub">propafenone</a><br />
+<a href="2D6references.asp#timololSub">timolol</a><br /><br />
+
+<strong>Antidepressants:</strong><br />
+<a href="2D6references.asp#amitriptylineSub">amitriptyline</a><br />
+<a href="2D6references.asp#clomipramineSub">clomipramine</a><br /> 
+<a href="2D6references.asp#desipramineSub">desipramine</a><br />
+<a href="2D6references.asp#fluoxetineSub">fluoxetine</a><br />
+<a href="2D6references.asp#imipramineSub">imipramine</a><br />  
+<a href="2D6references.asp#paroxetineSub">paroxetine</a><br /><br />
+
+<strong>Antipsychotics:</strong><br />
+<a href="2D6references.asp#haloperidolSub">haloperidol</a><br />
+<a href="2D6references.asp#perphenazineSub">perphenazine</a><br />
+<a href="2D6references.asp#risperidoneSub">risperidone&rarr;9-OH</a><br />
+<a href="2D6references.asp#thioridazineSub">thioridazine</a><br />
+<a href="2D6references.asp#zuclopenthixolSub">zuclopenthixol</a><br /><br />
+
+<a href="2D6references.asp#alprenololSub">alprenolol</a><br />
+<a href="2D6references.asp#amphetamineSub">amphetamine</a><br />
+<a href="2D6references.asp#aripiprazoleSub">aripiprazole</a><br />
+<a href="2D6references.asp#atomoxetineSub">atomoxetine</a><br />
+<a href="2D6references.asp#bufuralolSub">bufuralol</a><sup>1</sup><br />
+<a href="2D6references.asp#chlorpheniramineSub">chlorpheniramine</a><br />
+<a href="2D6references.asp#chlorpromazineSub">chlorpromazine</a><br />
+<a href="2D6references.asp#codeineSub">codeine (&rarr;O-desMe)</a><br />
+<a href="2D6references.asp#debrisoquineSub">debrisoquine</a><sup>2</sup><br />
+<a href="2D6references.asp#dexfenfluramineSub">dexfenfluramine</a><br />
+<a href="2D6references.asp#dextromethorphanSub">dextromethorphan</a><sup>1</sup><br />
+<a href="2D6references.asp#donepezilSub">donepezil</a><br />
+<a href="2D6references.asp#duloxetineSub">duloxetine</a><br />
+<a href="2D6references.asp#encainideSub">encainide</a><br />
+<a href="2D6references.asp#flecainideSub">flecainide</a><br />
+<a href="2D6references.asp#fluvoxamineSub">fluvoxamine</a><br />
+<a href="2D6references.asp#lidocaineSub">lidocaine</a><br /> 
+<a href="2D6references.asp#metoclopramideSub">metoclopramide</a><br />
+<a href="2D6references.asp#methoxyamphetamineSub">methoxyamphetamine</a><br />
+<a href="2D6references.asp#mexiletineSub">mexiletine</a><br />
+<a href="2D6references.asp#minaprineSub">minaprine</a><br />
+<a href="2D6references.asp#nebivololSub">nebivolol</a><br />
+<a href="2D6references.asp#nortriptylineSub">nortriptyline</a><br />
+<a href="2D6references.asp#ondansetronSub">ondansetron</a><br />
+<a href="2D6references.asp#oxycodoneSub">oxycodone</a><br />
+<a href="2D6references.asp#perhexilineSub">perhexiline</a><br />
+<a href="2D6references.asp#phenacetinSub">phenacetin</a><br />
+<a href="2D6references.asp#phenforminSub">phenformin</a><br />
+<a href="2D6references.asp#promethazineSub">promethazine</a><br />
+<a href="2D6references.asp#propranololSub">propranolol</a><br /> 
+<a href="2D6references.asp#sparteineSub">sparteine</a><br />
+<a href="2D6references.asp#tramadolSub">tramadol</a><br />
+<a href="2D6references.asp#venlafaxineSub">venlafaxine</a><br />
+</td>
+
+<td>
+<strong>Anesthetics:</strong><br />
+<a href="2E1references.asp#enfluraneSub">enflurane</a><br />
+<a href="2E1references.asp#halothaneSub">halothane</a><br />
+<a href="2E1references.asp#isofluraneSub">isoflurane</a><br />
+<a href="2E1references.asp#methoxyfluraneSub">methoxyflurane</a><br />
+<a href="2E1references.asp#sevofluraneSub">sevoflurane</a><br /><br />
+
+<a href="2E1references.asp#acetaminophenSub">acetaminophen&rarr;NAPQI</a><br />
+<a href="2E1references.asp#anilineSub">aniline</a>2<br />
+<a href="2E1references.asp#benzeneSub">benzene</a><br />
+<a href="2E1references.asp#chlorzoxazoneSub">chlorzoxazone</a>1<br />
+<a href="2E1references.asp#ethanolSub">ethanol</a><br />
+<a href="2E1references.asp#dimethylformamideSub">N,N-dimethylformamide</a><br />
+<a href="2E1references.asp#theophyllineSub">theophylline&rarr;8-OH</a>
+</td>
+
+<td>
+<strong>Macrolide antibiotics:</strong><br />
+<a href="3A457references.asp#clarithromycinSub">clarithromycin</a><br />
+<a href="3A457references.asp#erythromycinSub">erythromycin</a><sup>2</sup> (not 3A5)<br />
+<a href="3A457references.asp#azithromycinSub">NOT azithromycin</a><br />
+<a href="3A457references.asp#telithromycinSub">telithromycin</a><br /><br />
+
+<strong>Anti-arrhythmics:</strong><br />
+<a href="3A457references.asp#quinidineSub">quinidine</a>&rarr;3-OH (not 3A5)<br /><br />
+
+<strong>Benzodiazepines:</strong><br />
+<a href="3A457references.asp#alprazolamSub">alprazolam</a><br />
+<a href="3A457references.asp#diazepamSub">diazepam</a>&rarr;3OH<br />
+<a href="3A457references.asp#midazolamSub">midazolam</a><sup>1</sup><br />
+<a href="3A457references.asp#triazolamSub">triazolam</a><sup>2</sup><br /><br />
+
+<strong>Immune Modulators:</strong><br />
+<a href="3A457references.asp#cyclosporineSub">cyclosporine</a><br />
+<a href="3A457references.asp#tacrolimusSub">tacrolimus</a> (FK506)<br /><br />
+
+<strong>HIV Antivirals:</strong><br />
+<a href="3A457references.asp#indinavirSub">indinavir</a><br />
+<a href="3A457references.asp#nelfinavirSub">nelfinavir</a><br />
+<a href="3A457references.asp#ritonavirSub">ritonavir</a><br />
+<a href="3A457references.asp#saquinavirSub">saquinavir</a><br /><br />
+
+<strong>Prokinetic:</strong><br />
+<a href="3A457references.asp#cisaprideSub">cisapride</a><br /><br />
+
+<strong>Antihistamines:</strong><br />
+<a href="3A457references.asp#astemizoleSub">astemizole</a><br />
+<a href="3A457references.asp#chlorpheniramineSub">chlorpheniramine</a><br />
+<a href="3A457references.asp#terfenadineSub">terfenadine</a><sup>2</sup><br /><br />
+
+<strong>Calcium Channel Blockers:</strong><br />
+<a href="3A457references.asp#amlodipineSub">amlodipine</a><br />
+<a href="3A457references.asp#diltiazemSub">diltiazem</a><br />
+<a href="3A457references.asp#felodipineSub">felodipine</a><br />
+<a href="3A457references.asp#lercanidipineSub">lercanidipine</a><br />
+<a href="3A457references.asp#nifedipineSub">nifedipine</a><sup>2</sup><br />
+<a href="3A457references.asp#nisoldipineSub">nisoldipine</a><br />
+<a href="3A457references.asp#nitrendipineSub">nitrendipine</a><br />
+<a href="3A457references.asp#verapamilSub">verapamil</a><br /><br />
+
+<strong>HMG CoA Reductase Inhibitors:</strong><br />
+<a href="3A457references.asp#atorvastatinSub">atorvastatin</a><br />
+<a href="3A457references.asp#cerivastatinSub">cerivastatin </a><br />
+<a href="3A457references.asp#lovastatinSub">lovastatin</a><br />
+<a href="3A457references.asp#pravastatinSub">NOT pravastatin</a><br />
+<a href="3A457references.asp#rosuvastatinSub">NOT rosuvastatin</a><br />
+<a href="3A457references.asp#simvastatinSub">simvastatin</a><br /><br />
+
+<strong>Steroid 6beta-OH:</strong><br />
+<a href="3A457references.asp#estradiolSub">estradiol</a><br />
+<a href="3A457references.asp#hydrocortisoneSub">hydrocortisone</a><br />
+<a href="3A457references.asp#progesteroneSub">progesterone</a><br />
+<a href="3A457references.asp#testosteroneSub">testosterone</a><sup>1</sup><br /><br />
+
+<strong>Miscellaneous:</strong><br />
+<a href="3A457references.asp#alfentanilSub">alfentanil</a><br />
+<a href="3A457references.asp#aprepitantSub">aprepitant</a><br />
+<a href="3A457references.asp#aripiprazoleSub">aripiprazole</a><br />
+<a href="3A457references.asp#buspironeSub">buspirone</a><br />
+cafergot<br />
+<a href="3A457references.asp#caffeineSub">caffeine</a>&rarr;TMU<br />
+<a href="3A457references.asp#cilostazolSub">cilostazol</a><br />
+<a href="3A457references.asp#cocaineSub">cocaine</a><br />
+<a href="3A457references.asp#codeineSub">codeine-N-demethylation</a><br />
+<a href="3A457references.asp#dapsoneSub">dapsone</a><br />
+<a href="3A457references.asp#dexamethasoneSub">dexamethasone</a><br />
+<a href="3A457references.asp#dextromethorphanSub">dextromethorphan</a><sup>2</sup><br />
+<a href="3A457references.asp#docetaxelSub">docetaxel</a><br />
+<a href="3A457references.asp#domperidoneSub">domperidone</a><br />
+<a href="3A457references.asp#eplerenoneSub">eplerenone</a><br />
+<a href="3A457references.asp#fentanylSub">fentanyl</a><br />
+<a href="3A457references.asp#finasterideSub">finasteride</a><br />
+<a href="3A457references.asp#gleevecSub">gleevec</a><br />
+<a href="3A457references.asp#haloperidolSub">haloperidol</a><br />
+<a href="3A457references.asp#irinotecanSub">irinotecan</a><br />
+<a href="3A457references.asp#methadoneSub">LAAM</a><br />
+<a href="3A457references.asp#lidocaineSub">lidocaine</a><br />
+<a href="3A457references.asp#methadoneSub">methadone</a><br />
+<a href="3A457references.asp#nateglinideSub">nateglinide</a><br />
+<a href="3A457references.asp#ondansetronSub">ondansetron</a><br />
+<a href="3A457references.asp#pimozideSub">pimozide</a><br />
+<a href="3A457references.asp#propranololSub">propranolol</a><br />
+<a href="3A457references.asp#quetiapineSub">quetiapine</a><br />
+<a href="3A457references.asp#quinineSub">quinine</a><br />
+<a href="3A457references.asp#risperidoneSub">risperidone</a><br />
+<a href="3A457references.asp#salmeterolSub">salmeterol</a><br />
+<a href="3A457references.asp#sildenafilSub">sildenafil</a><br />
+<a href="3A457references.asp#sirolimusSub">sirolimus</a><br />
+<a href="3A457references.asp#sorafenibSub">sorafenib</a><br />
+<a href="3A457references.asp#sunitinibSub">sunitinib</a><br />
+<a href="3A457references.asp#tamoxifenSub">tamoxifen</a><br />
+<a href="3A457references.asp#taxolSub">taxol</a><br />
+<a href="3A457references.asp#terfenadineSub">terfenadine</a><br />
+<a href="3A457references.asp#toriselSub">torisel</a><br />
+<a href="3A457references.asp#trazodoneSub">trazodone</a><br />
+<a href="3A457references.asp#vincristineSub">vincristine</a><br />
+<a href="3A457references.asp#zaleplonSub">zaleplon</a><br />
+<a href="3A457references.asp#ziprasidoneSub">ziprasidone</a><br />
+<a href="3A457references.asp#zolpidemSub">zolpidem</a>
+</td>
+</tr>
+
+<tr><td colspan="8"><hr /><h1>INHIBITORS</h1></td></tr>
+
+<tr><td colspan="8">
+Inhibitors compete with other drugs for a particular enzyme thus affecting the optimal level of metabolism of the substrate drug which in many cases affect the individual's response to that particular medication, e.g. making it ineffective.<br />
+
+<p>
+<img src="/images/clinpharm/red.jpg" /> A <b>Strong inhibitor</b> is one that causes a > 5-fold increase in the plasma AUC values or more than 80% decrease in clearance.<br>
+<img src="/images/clinpharm/orange.jpg" /> A <b>Moderate inhibitor</b> is one that causes a > 2-fold increase in the plasma AUC values or 50-80% decrease in clearance.<br>
+<img src="/images/clinpharm/green.jpg" /> A <b>Weak inhibitor</b> is one that causes a > 1.25-fold but < 2-fold increase in the plasma AUC values or 20-50% decrease in clearance.<br>
+<img src="/images/clinpharm/blue.jpg" /> All other inhibitors.
+</p>
+
+<p>FDA preferred<sup>1</sup> and acceptable<sup>2</sup> <b>inhibitors</b> for in vitro experiments.*</p>
+
+
+</td></tr>
+
+<!-- 
+<tr align="center">
+<td></td>
+<td></td>
+<td></td>
+<td></td>
+<td></td>
+<td style="BORDER-RIGHT: orange solid; BORDER-TOP: orange solid; BORDER-LEFT: orange solid; BORDER-BOTTOM: orange solid" width="140" height="24" bgcolor="FFFFFF" ><a href="inhibitorData.asp">Utilization of 2D6 medications and tamoxifen</a></td>
+<td></td>
+<td></td>
+</tr>
+-->
+
+<tr bgcolor="#CCCCCC" align="center">
+<td>1A2</td>
+<td>2B6</td>
+<td>2C8</td>
+<td>2C9</td>
+<td>2C19</td>
+<td>2D6</td>
+<td>2E1</td>
+<td>3A4,5,7</td>
+</tr>
+
+<tr valign="top">
+<td>
+<img src="/images/clinpharm/red.jpg" /> <a href="1A2references.asp#fluvoxamineInh">fluvoxamine</a><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="1A2references.asp#ciprofloxacinInh">ciprofloxacin</a><br /><br />
+
+<img src="/images/clinpharm/green.jpg" /> <a href="1A2references.asp#cimetidineInh">cimetidine</a><br /><br />
+
+<a href="1A2references.asp#amiodaroneInh">amiodarone</a><br />
+<a href="1A2references.asp#fluoroInh">fluoroquinolones</a><br />
+<a href="1A2references.asp#furafyllineInh">furafylline</a><sup>1</sup><br />
+<a href="1A2references.asp#interferonInh">interferon</a><br />
+<a href="1A2references.asp#methoxsalenInh">methoxsalen</a><br />
+<a href="1A2references.asp#mibefradilInh">mibefradil</a>
+</td>
+
+<td>
+<a href="2B6references.asp#thiotepaInh">thiotepa</a><br />
+<a href="2B6references.asp#ticlopidineInh">ticlopidine</a><sup>2</sup>
+</td>
+
+<td>
+<img src="/images/clinpharm/red.jpg" /> <a href="2C8references.asp#gemfibrozilInh">gemfibrozil</a><sup>2</sup><br /><br />
+
+<img src="/images/clinpharm/orange.jpg" /> <a href="2C8references.asp#trimethoprimInh">trimethoprim</a><sup>2</sup><br /><br />
+
+<a href="2C8references.asp#glitazonesInh">glitazones</a><br />
+<a href="2C8references.asp#montelukastInh">montelukast</a><sup>1</sup><br />
+<a href="2C8references.asp#quercetinInh">quercetin</a><sup>1</sup>
+</td>
+
+<td>
+<img src="/images/clinpharm/red.jpg" /> <a href="2C9references.asp#fluconazoleInh">fluconazole</a><sup>2</sup><br /><br />
+
+<img src="/images/clinpharm/orange.jpg" /> <a href="2C9references.asp#amiodaroneInh">amiodarone</a><br /><br />
+
+<a href="2C9references.asp#fenofibrateInh">fenofibrate</a><br />
+<a href="2C9references.asp#fluvastatinInh">fluvastatin</a><br />
+<a href="2C9references.asp#fluvoxamineInh">fluvoxamine</a><sup>2</sup><br />
+<a href="2C9references.asp#isoniazidInh">isoniazid</a><br />
+<a href="2C9references.asp#lovastatinInh">lovastatin</a><br />
+<a href="2C9references.asp#phenylbutazoneInh">phenylbutazone</a><br />
+<a href="2C9references.asp#probenicidInh">probenicid</a><br />
+<a href="2C9references.asp#sertralineInh">sertraline</a><br />
+<a href="2C9references.asp#sulfamethoxazoleInh">sulfamethoxazole</a><br />
+<a href="2C9references.asp#sulfaphenazoleInh">sulfaphenazole</a><sup>1</sup><br />
+<a href="2C9references.asp#teniposideInh">teniposide</a><br />
+<a href="2C9references.asp#voriconazoleInh">voriconazole</a><br />
+<a href="2C9references.asp#zafirlukastInh">zafirlukast</a>
+</td>
+
+<td>
+PPIs:<br />
+<a href="2C19references.asp#lansoprazoleInh">lansoprazole</a><br />
+<a href="2C19references.asp#omeprazoleInh">omeprazole</a>2<br />
+<a href="2C19references.asp#pantoprazoleInh">pantoprazole</a><br />
+<a href="2C19references.asp#rabeprazoleInh">rabeprazole</a><br /><br />
+
+<a href="2C19references.asp#chloramphenicolInh">chloramphenicol</a><br />
+<a href="2C19references.asp#cimetidineInh">cimetidine</a><br />
+<a href="2C19references.asp#felbamateInh">felbamate</a><br />
+<a href="2C19references.asp#fluoxetineInh">fluoxetine</a><br />
+<a href="2C19references.asp#fluvoxamineInh">fluvoxamine</a><br />
+<a href="2C19references.asp#indomethacinInh">indomethacin</a><br />
+<a href="2C19references.asp#ketoconazoleInh">ketoconazole</a><br />
+<a href="2C19references.asp#modafinilInh">modafinil</a><br />
+<a href="2C19references.asp#oxcarbazepineInh">oxcarbazepine</a><br />
+<a href="2C19references.asp#probenicidInh">probenicid</a><br />
+<a href="2C19references.asp#ticlopidineInh">ticlopidine</a>2<br />
+<a href="2C19references.asp#topiramateInh">topiramate</a>
+</td>
+
+<td>
+<img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#bupropionInh">bupropion</a><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#cinacalcetInh">cinacalcet</a><br>
+
+<img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#fluoxetineInh">fluoxetine</a><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#paroxetineInh">paroxetine</a><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="2D6references.asp#quinidineInh">quinidine</a><sup>1</sup><br /><br />
+
+<img src="/images/clinpharm/orange.jpg" /> <a href="2D6references.asp#duloxetineInh">duloxetine</a><br />
+<img src="/images/clinpharm/orange.jpg" /> <a href="2D6references.asp#sertralineInh">sertraline</a><br />
+<img src="/images/clinpharm/orange.jpg" /> <a href="2D6references.asp#terbinafineInh">terbinafine</a><br /><br />
+
+<img src="/images/clinpharm/green.jpg" /> <a href="2D6references.asp#amiodaroneInh">amiodarone</a><br />
+<img src="/images/clinpharm/green.jpg" /> <a href="2D6references.asp#cimetidineInh">cimetidine</a><br /><br />
+
+<a href="2D6references.asp#celecoxibInh">celecoxib</a><br />
+chlorpheniramine<br />
+chlorpromazine<br />
+<a href="2D6references.asp#citalopramInh">citalopram</a><br />
+clemastine<br />
+<a href="2D6references.asp#clomipramineInh">clomipramine</a><br />
+<a href="2D6references.asp#cocaineInh">cocaine</a><br />
+diphenhydramine<br />
+doxepin<br />
+<a href="2D6references.asp#doxorubicinInh">doxorubicin</a><br />
+<a href="2D6references.asp#escitalopramInh">escitalopram</a><br />
+<a href="2D6references.asp#halofantrineInh">halofantrine</a><br />
+<a href="2D6references.asp#histamineInh">histamine H1 receptor antagonists</a><br />
+hydroxyzine<br />
+<a href="2D6references.asp#levomepromazineInh">levomepromazine</a><br />
+<a href="2D6references.asp#methadoneInh">methadone</a><br />
+metoclopramide<br />
+mibefradil<br />
+<a href="2D6references.asp#midodrineInh">midodrine</a><br />
+<a href="2D6references.asp#moclobemideInh">moclobemide</a><br />
+perphenazine<br />
+ranitidine<br />
+<a href="2D6references.asp#haloperidolInh">reduced-haloperidol</a><br />
+<a href="2D6references.asp#ritonavirInh">ritonavir</a><br />
+ticlopidine<br />
+tripelennamine
+</td>
+
+<td>
+<a href="2E1references.asp#dithiocarbamateInh">diethyl-dithiocarbamate</a><sup>2</sup><br />
+<a href="2E1references.asp#disulfiramInh">disulfiram</a>
+</td>
+
+<td>
+HIV Antivirals:<br />
+<img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#indinavirInh">indinavir</a><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#nelfinavirInh">nelfinavir</a><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#ritonavirInh">ritonavir</a><br /><br />
+
+<img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#clarithromycinInh">clarithromycin</a><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#itraconazoleInh">itraconazole</a><sup>1</sup><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#ketoconazoleInh">ketoconazole</a><sup>1</sup><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#nefazodoneInh">nefazodone</a><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#saquinavirInh">saquinavir</a><br />
+<img src="/images/clinpharm/red.jpg" /> <a href="3A457references.asp#telithromycinInh">telithromycin</a><br /><br />
+
+<img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#aprepitantInh">aprepitant</a><br />
+<img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#erythromycinInh">erythromycin</a><br />
+<img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#fluconazoleInh">fluconazole</a><br />
+<img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#grapefruitInh">grapefruit juice</a><br />
+<img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#verapamilInh">verapamil</a><sup>2</sup><br />
+<img src="/images/clinpharm/orange.jpg" /> <a href="3A457references.asp#diltiazemInh">diltiazem</a><br /><br />
+
+<img src="/images/clinpharm/green.jpg" /> <a href="3A457references.asp#cimetidineInh">cimetidine</a><br /><br />
+
+<a href="3A457references.asp#amiodaroneInh">amiodarone</a><br />
+<a href="3A457references.asp#azithromycinInh">NOT azithromycin</a><br />
+chloramphenicol<br />
+<a href="3A457references.asp#ciprofloxacinInh">ciprofloxacin</a><br />
+<a href="3A457references.asp#delaviridineInh">delaviridine</a><br /><br />
+<a href="3A457references.asp#dithiocarbamateInh">diethyl-dithiocarbamate</a><br />
+<a href="3A457references.asp#fluvoxamineInh">fluvoxamine</a><br />
+<a href="3A457references.asp#gestodeneInh">gestodene</a><br />
+<a href="3A457references.asp#imatinibInh">imatinib</a><br />
+<a href="3A457references.asp#mibefradilInh">mibefradil</a><br />
+<a href="3A457references.asp#mifepristoneInh">mifepristone</a><br />
+<a href="3A457references.asp#norfloxacinInh">norfloxacin</a><br />
+<a href="3A457references.asp#norfluoxetineInh">norfluoxetine</a><br />
+<a href="3A457references.asp#starfruitInh">starfruit</a><br />
+<a href="3A457references.asp#voriconazoleInh">voriconazole</a>
+</td>
+</tr>
+
+<tr><td colspan="8"><hr /><h1>INDUCERS</h1></td></tr>
+
+<tr bgcolor="#CCCCCC" align="center">
+<td>1A2</td>
+<td>2B6</td>
+<td>2C8</td>
+<td>2C9</td>
+<td>2C19</td>
+<td>2D6</td>
+<td>2E1</td>
+<td>3A4,5,7</td>
+</tr>
+
+<tr valign="top">
+
+<td>
+<a href="1A2references.asp#broccoliInd">broccoli</a><br />
+<a href="1A2references.asp#brusselInd">brussel sprouts</a><br />
+<a href="1A2references.asp#charInd">char-grilled meat</a><br />
+<a href="1A2references.asp#insulinInd">insulin</a><br />
+<a href="1A2references.asp#methylInd">methylcholanthrene</a><sup>1</sup><br />
+<a href="1A2references.asp#modafinilInd">modafinil</a><br />
+<a href="1A2references.asp#nafcillinInd">nafcillin</a><br />
+<a href="1A2references.asp#betaInd">beta-naphthoflavone</a><sup>1</sup><br />
+<a href="1A2references.asp#omeprazoleInd">omeprazole</a><sup>1</sup><br />
+<a href="1A2references.asp#tobaccoInd">tobacco</a><br />
+</td>
+
+<td>
+<a href="2B6references.asp#phenobarbitalInd">phenobarbital</a><br />
+<a href="2B6references.asp#phenytoinInd">phenytoin</a><br />
+<a href="2B6references.asp#rifampinInd">rifampin</a>
+</td>
+
+<td>
+<a href="2C8references.asp#rifampicinInd">rifampin</a><sup>1</sup>
+</td>
+
+<td>
+<a href="2C9references.asp#rifampinInd">rifampin</a><br />
+<a href="2C9references.asp#secobarbitalInd">secobarbital</a>
+</td>
+
+<td>
+<a href="2C19references.asp#carbamazepineInd">carbamazepine</a><br />
+<a href="2C19references.asp#norethindroneInd">norethindrone</a><br />
+<a href="2C19references.asp#pentobarbitalInd">NOT pentobarbital</a><br />
+<a href="2C19references.asp#prednisoneInd">prednisone</a><br />
+<a href="2C19references.asp#rifampicinInd">rifampicin</a><sup>1</sup>
+</td>
+
+<td>
+<a href="2D6references.asp#dexamethasoneInd">dexamethasone</a><br />
+<a href="2D6references.asp#rifampinInd">rifampin</a><br />
+
+
+</td>
+
+<td>
+<a href="2E1references.asp#ethanolInd">ethanol</a><br />
+<a href="2E1references.asp#isoniazidInd">isoniazid</a>
+</td>
+
+
+<td>
+HIV Antivirals:<br />
+<a href="3A457references.asp#efavirenzInd">efavirenz</a><br />
+<a href="3A457references.asp#nevirapineInd">nevirapine</a><br /><br />
+
+<a href="3A457references.asp#barbituratesInd">barbiturates</a><br />
+<a href="3A457references.asp#carbamazepineInd">carbamazepine</a><br />
+<a href="3A457references.asp#glucocorticoidsInd">glucocorticoids</a><br />
+<a href="3A457references.asp#modafinilInd">modafinil</a><br />
+<a href="3A457references.asp#oxcarbazepineInd">oxcarbazepine</a><br />
+<a href="3A457references.asp#phenobarbitalInd">phenobarbital</a><sup>2</sup><br />
+<a href="3A457references.asp#phenytoinInd">phenytoin</a><sup>2</sup><br />
+<a href="3A457references.asp#pioglitazoneInd">pioglitazone</a><br />
+<a href="3A457references.asp#rifabutinInd">rifabutin</a><br />
+<a href="3A457references.asp#rifampinInd">rifampin</a><sup>1</sup><br />
+<a href="3A457references.asp#stjohnswortInd">St. John's wort</a><br />
+<a href="3A457references.asp#troglitazone1Ind">troglitazone</a><sup>1</sup>
+</td>
+</tr>
+</table>
+
+	<!-- End Main Body -->  
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