tooluniverse 1.0.6__py3-none-any.whl → 1.0.8__py3-none-any.whl

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  1. tooluniverse/__init__.py +56 -10
  2. tooluniverse/admetai_tool.py +8 -4
  3. tooluniverse/agentic_tool.py +40 -4
  4. tooluniverse/arxiv_tool.py +2 -6
  5. tooluniverse/base_tool.py +210 -25
  6. tooluniverse/biogrid_tool.py +118 -0
  7. tooluniverse/biorxiv_tool.py +35 -16
  8. tooluniverse/build_optimizer.py +87 -0
  9. tooluniverse/cache/__init__.py +3 -0
  10. tooluniverse/cache/memory_cache.py +99 -0
  11. tooluniverse/cache/result_cache_manager.py +235 -0
  12. tooluniverse/cache/sqlite_backend.py +257 -0
  13. tooluniverse/cellosaurus_tool.py +1332 -0
  14. tooluniverse/clinvar_tool.py +90 -0
  15. tooluniverse/compose_scripts/enhanced_multi_agent_literature_search.py +310 -0
  16. tooluniverse/compose_scripts/multi_agent_literature_search.py +794 -0
  17. tooluniverse/compose_scripts/tool_graph_generation.py +68 -35
  18. tooluniverse/compose_scripts/tool_metadata_generator.py +205 -105
  19. tooluniverse/compose_tool.py +93 -8
  20. tooluniverse/core_tool.py +46 -44
  21. tooluniverse/crossref_tool.py +89 -4
  22. tooluniverse/custom_tool.py +28 -0
  23. tooluniverse/data/agentic_tools.json +1271 -1179
  24. tooluniverse/data/alphafold_tools.json +356 -105
  25. tooluniverse/data/arxiv_tools.json +85 -81
  26. tooluniverse/data/biorxiv_tools.json +69 -64
  27. tooluniverse/data/cellosaurus_tools.json +260 -0
  28. tooluniverse/data/chembl_tools.json +27 -12
  29. tooluniverse/data/clinicaltrials_gov_tools.json +377 -302
  30. tooluniverse/data/compose_tools.json +123 -16
  31. tooluniverse/data/core_tools.json +104 -99
  32. tooluniverse/data/crossref_tools.json +131 -63
  33. tooluniverse/data/dailymed_tools.json +17 -3
  34. tooluniverse/data/dataset_tools.json +1031 -588
  35. tooluniverse/data/dblp_tools.json +135 -64
  36. tooluniverse/data/disease_target_score_tools.json +20 -10
  37. tooluniverse/data/doaj_tools.json +131 -87
  38. tooluniverse/data/drug_discovery_agents.json +292 -0
  39. tooluniverse/data/embedding_tools.json +362 -299
  40. tooluniverse/data/enrichr_tools.json +34 -27
  41. tooluniverse/data/europe_pmc_tools.json +107 -16
  42. tooluniverse/data/fatcat_tools.json +71 -66
  43. tooluniverse/data/fda_drug_adverse_event_tools.json +1061 -445
  44. tooluniverse/data/fda_drug_labeling_tools.json +6858 -6901
  45. tooluniverse/data/finder_tools.json +32 -37
  46. tooluniverse/data/gene_ontology_tools.json +19 -7
  47. tooluniverse/data/genomics_tools.json +174 -0
  48. tooluniverse/data/geo_tools.json +86 -0
  49. tooluniverse/data/gwas_tools.json +1720 -959
  50. tooluniverse/data/hal_tools.json +69 -64
  51. tooluniverse/data/hpa_tools.json +53 -14
  52. tooluniverse/data/humanbase_tools.json +51 -43
  53. tooluniverse/data/idmap_tools.json +76 -70
  54. tooluniverse/data/literature_search_tools.json +306 -0
  55. tooluniverse/data/markitdown_tools.json +51 -0
  56. tooluniverse/data/mcp_client_tools_example.json +122 -107
  57. tooluniverse/data/medlineplus_tools.json +50 -10
  58. tooluniverse/data/medrxiv_tools.json +69 -64
  59. tooluniverse/data/molecule_2d_tools.json +134 -0
  60. tooluniverse/data/molecule_3d_tools.json +164 -0
  61. tooluniverse/data/monarch_tools.json +112 -110
  62. tooluniverse/data/odphp_tools.json +389 -119
  63. tooluniverse/data/openaire_tools.json +89 -79
  64. tooluniverse/data/openalex_tools.json +96 -31
  65. tooluniverse/data/opentarget_tools.json +1457 -1372
  66. tooluniverse/data/osf_preprints_tools.json +77 -73
  67. tooluniverse/data/packages/bioinformatics_core_tools.json +40 -10
  68. tooluniverse/data/packages/cheminformatics_tools.json +20 -5
  69. tooluniverse/data/packages/genomics_tools.json +36 -9
  70. tooluniverse/data/packages/machine_learning_tools.json +36 -9
  71. tooluniverse/data/packages/scientific_computing_tools.json +20 -5
  72. tooluniverse/data/packages/single_cell_tools.json +20 -5
  73. tooluniverse/data/packages/structural_biology_tools.json +16 -4
  74. tooluniverse/data/packages/visualization_tools.json +20 -5
  75. tooluniverse/data/pmc_tools.json +108 -103
  76. tooluniverse/data/ppi_tools.json +139 -0
  77. tooluniverse/data/protein_structure_3d_tools.json +138 -0
  78. tooluniverse/data/pubchem_tools.json +37 -12
  79. tooluniverse/data/pubmed_tools.json +124 -58
  80. tooluniverse/data/pubtator_tools.json +68 -60
  81. tooluniverse/data/rcsb_pdb_tools.json +1532 -1221
  82. tooluniverse/data/semantic_scholar_tools.json +54 -22
  83. tooluniverse/data/special_tools.json +8 -6
  84. tooluniverse/data/tool_composition_tools.json +112 -82
  85. tooluniverse/data/unified_guideline_tools.json +909 -0
  86. tooluniverse/data/url_fetch_tools.json +102 -82
  87. tooluniverse/data/uspto_tools.json +49 -30
  88. tooluniverse/data/wikidata_sparql_tools.json +42 -39
  89. tooluniverse/data/xml_tools.json +3274 -3113
  90. tooluniverse/data/zenodo_tools.json +83 -76
  91. tooluniverse/dblp_tool.py +76 -6
  92. tooluniverse/dbsnp_tool.py +71 -0
  93. tooluniverse/default_config.py +19 -0
  94. tooluniverse/doaj_tool.py +76 -17
  95. tooluniverse/doctor.py +48 -0
  96. tooluniverse/ensembl_tool.py +61 -0
  97. tooluniverse/europe_pmc_tool.py +132 -17
  98. tooluniverse/exceptions.py +170 -0
  99. tooluniverse/execute_function.py +930 -387
  100. tooluniverse/fatcat_tool.py +0 -1
  101. tooluniverse/generate_tools.py +481 -0
  102. tooluniverse/genomics_gene_search_tool.py +56 -0
  103. tooluniverse/geo_tool.py +116 -0
  104. tooluniverse/gnomad_tool.py +63 -0
  105. tooluniverse/hal_tool.py +1 -1
  106. tooluniverse/llm_clients.py +101 -124
  107. tooluniverse/markitdown_tool.py +159 -0
  108. tooluniverse/mcp_client_tool.py +10 -5
  109. tooluniverse/mcp_tool_registry.py +4 -1
  110. tooluniverse/medrxiv_tool.py +32 -13
  111. tooluniverse/memory_manager.py +166 -0
  112. tooluniverse/molecule_2d_tool.py +274 -0
  113. tooluniverse/molecule_3d_tool.py +441 -0
  114. tooluniverse/odphp_tool.py +49 -14
  115. tooluniverse/openaire_tool.py +5 -20
  116. tooluniverse/openalex_tool.py +34 -0
  117. tooluniverse/osf_preprints_tool.py +1 -1
  118. tooluniverse/pmc_tool.py +54 -56
  119. tooluniverse/protein_structure_3d_tool.py +295 -0
  120. tooluniverse/pubmed_tool.py +69 -6
  121. tooluniverse/remote/boltz/boltz_mcp_server.py +3 -1
  122. tooluniverse/remote/uspto_downloader/uspto_downloader_mcp_server.py +3 -1
  123. tooluniverse/semantic_scholar_tool.py +40 -10
  124. tooluniverse/smcp.py +149 -213
  125. tooluniverse/smcp_server.py +97 -55
  126. tooluniverse/string_tool.py +112 -0
  127. tooluniverse/tool_registry.py +35 -3
  128. tooluniverse/tools/ADMETAI_predict_BBB_penetrance.py +46 -0
  129. tooluniverse/tools/ADMETAI_predict_CYP_interactions.py +46 -0
  130. tooluniverse/tools/ADMETAI_predict_bioavailability.py +46 -0
  131. tooluniverse/tools/ADMETAI_predict_clearance_distribution.py +49 -0
  132. tooluniverse/tools/ADMETAI_predict_nuclear_receptor_activity.py +49 -0
  133. tooluniverse/tools/ADMETAI_predict_physicochemical_properties.py +49 -0
  134. tooluniverse/tools/ADMETAI_predict_solubility_lipophilicity_hydration.py +49 -0
  135. tooluniverse/tools/ADMETAI_predict_stress_response.py +46 -0
  136. tooluniverse/tools/ADMETAI_predict_toxicity.py +46 -0
  137. tooluniverse/tools/ADMETAnalyzerAgent.py +59 -0
  138. tooluniverse/tools/AdvancedCodeQualityAnalyzer.py +63 -0
  139. tooluniverse/tools/AdverseEventICDMapper.py +46 -0
  140. tooluniverse/tools/AdverseEventPredictionQuestionGenerator.py +52 -0
  141. tooluniverse/tools/AdverseEventPredictionQuestionGeneratorWithContext.py +59 -0
  142. tooluniverse/tools/ArXiv_search_papers.py +63 -0
  143. tooluniverse/tools/ArgumentDescriptionOptimizer.py +55 -0
  144. tooluniverse/tools/BioRxiv_search_preprints.py +52 -0
  145. tooluniverse/tools/BiomarkerDiscoveryWorkflow.py +55 -0
  146. tooluniverse/tools/CMA_Guidelines_Search.py +52 -0
  147. tooluniverse/tools/CORE_search_papers.py +67 -0
  148. tooluniverse/tools/CallAgent.py +46 -0
  149. tooluniverse/tools/ChEMBL_search_similar_molecules.py +59 -0
  150. tooluniverse/tools/ClinVar_search_variants.py +52 -0
  151. tooluniverse/tools/ClinicalTrialDesignAgent.py +63 -0
  152. tooluniverse/tools/CodeOptimizer.py +55 -0
  153. tooluniverse/tools/CodeQualityAnalyzer.py +71 -0
  154. tooluniverse/tools/CompoundDiscoveryAgent.py +59 -0
  155. tooluniverse/tools/ComprehensiveDrugDiscoveryPipeline.py +49 -0
  156. tooluniverse/tools/Crossref_search_works.py +55 -0
  157. tooluniverse/tools/DBLP_search_publications.py +52 -0
  158. tooluniverse/tools/DOAJ_search_articles.py +55 -0
  159. tooluniverse/tools/DailyMed_get_spl_by_setid.py +52 -0
  160. tooluniverse/tools/DailyMed_search_spls.py +79 -0
  161. tooluniverse/tools/DataAnalysisValidityReviewer.py +49 -0
  162. tooluniverse/tools/DescriptionAnalyzer.py +55 -0
  163. tooluniverse/tools/DescriptionQualityEvaluator.py +59 -0
  164. tooluniverse/tools/DiseaseAnalyzerAgent.py +52 -0
  165. tooluniverse/tools/DomainExpertValidator.py +63 -0
  166. tooluniverse/tools/DrugInteractionAnalyzerAgent.py +52 -0
  167. tooluniverse/tools/DrugOptimizationAgent.py +63 -0
  168. tooluniverse/tools/DrugSafetyAnalyzer.py +59 -0
  169. tooluniverse/tools/Ensembl_lookup_gene_by_symbol.py +52 -0
  170. tooluniverse/tools/EthicalComplianceReviewer.py +49 -0
  171. tooluniverse/tools/EuropePMC_Guidelines_Search.py +52 -0
  172. tooluniverse/tools/EuropePMC_search_articles.py +52 -0
  173. tooluniverse/tools/ExperimentalDesignScorer.py +55 -0
  174. tooluniverse/tools/FAERS_count_additive_administration_routes.py +52 -0
  175. tooluniverse/tools/FAERS_count_additive_adverse_reactions.py +71 -0
  176. tooluniverse/tools/FAERS_count_additive_event_reports_by_country.py +63 -0
  177. tooluniverse/tools/FAERS_count_additive_reaction_outcomes.py +63 -0
  178. tooluniverse/tools/FAERS_count_additive_reports_by_reporter_country.py +63 -0
  179. tooluniverse/tools/FAERS_count_additive_seriousness_classification.py +63 -0
  180. tooluniverse/tools/FAERS_count_country_by_drug_event.py +63 -0
  181. tooluniverse/tools/FAERS_count_death_related_by_drug.py +49 -0
  182. tooluniverse/tools/FAERS_count_drug_routes_by_event.py +52 -0
  183. tooluniverse/tools/FAERS_count_drugs_by_drug_event.py +63 -0
  184. tooluniverse/tools/FAERS_count_outcomes_by_drug_event.py +63 -0
  185. tooluniverse/tools/FAERS_count_patient_age_distribution.py +49 -0
  186. tooluniverse/tools/FAERS_count_reactions_by_drug_event.py +71 -0
  187. tooluniverse/tools/FAERS_count_reportercountry_by_drug_event.py +63 -0
  188. tooluniverse/tools/FAERS_count_seriousness_by_drug_event.py +63 -0
  189. tooluniverse/tools/FDA_get_abuse_dependence_info_by_drug_name.py +55 -0
  190. tooluniverse/tools/FDA_get_abuse_info_by_drug_name.py +55 -0
  191. tooluniverse/tools/FDA_get_accessories_info_by_drug_name.py +55 -0
  192. tooluniverse/tools/FDA_get_active_ingredient_info_by_drug_name.py +55 -0
  193. tooluniverse/tools/FDA_get_adverse_reactions_by_drug_name.py +55 -0
  194. tooluniverse/tools/FDA_get_alarms_by_drug_name.py +55 -0
  195. tooluniverse/tools/FDA_get_animal_pharmacology_info_by_drug_name.py +55 -0
  196. tooluniverse/tools/FDA_get_assembly_installation_info_by_drug_name.py +55 -0
  197. tooluniverse/tools/FDA_get_boxed_warning_info_by_drug_name.py +55 -0
  198. tooluniverse/tools/FDA_get_brand_name_generic_name.py +52 -0
  199. tooluniverse/tools/FDA_get_calibration_instructions_by_drug_name.py +55 -0
  200. tooluniverse/tools/FDA_get_carcinogenic_mutagenic_fertility_by_drug_name.py +55 -0
  201. tooluniverse/tools/FDA_get_child_safety_info_by_drug_name.py +55 -0
  202. tooluniverse/tools/FDA_get_clinical_pharmacology_by_drug_name.py +55 -0
  203. tooluniverse/tools/FDA_get_clinical_studies_info_by_drug_name.py +55 -0
  204. tooluniverse/tools/FDA_get_contact_for_questions_info_by_drug_name.py +55 -0
  205. tooluniverse/tools/FDA_get_contraindications_by_drug_name.py +55 -0
  206. tooluniverse/tools/FDA_get_controlled_substance_DEA_schedule_info_by_drug_name.py +55 -0
  207. tooluniverse/tools/FDA_get_dear_health_care_provider_letter_info_by_drug_name.py +55 -0
  208. tooluniverse/tools/FDA_get_dependence_info_by_drug_name.py +55 -0
  209. tooluniverse/tools/FDA_get_disposal_info_by_drug_name.py +55 -0
  210. tooluniverse/tools/FDA_get_do_not_use_info_by_drug_name.py +55 -0
  211. tooluniverse/tools/FDA_get_document_id_by_drug_name.py +55 -0
  212. tooluniverse/tools/FDA_get_dosage_and_storage_information_by_drug_name.py +55 -0
  213. tooluniverse/tools/FDA_get_dosage_forms_and_strengths_by_drug_name.py +55 -0
  214. tooluniverse/tools/FDA_get_drug_generic_name.py +46 -0
  215. tooluniverse/tools/FDA_get_drug_interactions_by_drug_name.py +55 -0
  216. tooluniverse/tools/FDA_get_drug_name_by_SPL_ID.py +55 -0
  217. tooluniverse/tools/FDA_get_drug_name_by_adverse_reaction.py +59 -0
  218. tooluniverse/tools/FDA_get_drug_name_by_calibration_instructions.py +59 -0
  219. tooluniverse/tools/FDA_get_drug_name_by_dependence_info.py +59 -0
  220. tooluniverse/tools/FDA_get_drug_name_by_document_id.py +55 -0
  221. tooluniverse/tools/FDA_get_drug_name_by_dosage_info.py +55 -0
  222. tooluniverse/tools/FDA_get_drug_name_by_environmental_warning.py +59 -0
  223. tooluniverse/tools/FDA_get_drug_name_by_inactive_ingredient.py +59 -0
  224. tooluniverse/tools/FDA_get_drug_name_by_info_on_conditions_for_doctor_consultation.py +55 -0
  225. tooluniverse/tools/FDA_get_drug_name_by_labor_and_delivery_info.py +59 -0
  226. tooluniverse/tools/FDA_get_drug_name_by_microbiology.py +59 -0
  227. tooluniverse/tools/FDA_get_drug_name_by_other_safety_info.py +55 -0
  228. tooluniverse/tools/FDA_get_drug_name_by_pharmacodynamics.py +59 -0
  229. tooluniverse/tools/FDA_get_drug_name_by_pharmacogenomics.py +59 -0
  230. tooluniverse/tools/FDA_get_drug_name_by_precautions.py +55 -0
  231. tooluniverse/tools/FDA_get_drug_name_by_pregnancy_or_breastfeeding_info.py +59 -0
  232. tooluniverse/tools/FDA_get_drug_name_by_principal_display_panel.py +59 -0
  233. tooluniverse/tools/FDA_get_drug_name_by_reference.py +55 -0
  234. tooluniverse/tools/FDA_get_drug_name_by_set_id.py +55 -0
  235. tooluniverse/tools/FDA_get_drug_name_by_stop_use_info.py +55 -0
  236. tooluniverse/tools/FDA_get_drug_name_by_storage_and_handling_info.py +55 -0
  237. tooluniverse/tools/FDA_get_drug_name_by_warnings.py +55 -0
  238. tooluniverse/tools/FDA_get_drug_name_from_patient_package_insert.py +59 -0
  239. tooluniverse/tools/FDA_get_drug_names_by_abuse_dependence_info.py +55 -0
  240. tooluniverse/tools/FDA_get_drug_names_by_abuse_info.py +63 -0
  241. tooluniverse/tools/FDA_get_drug_names_by_accessories.py +63 -0
  242. tooluniverse/tools/FDA_get_drug_names_by_active_ingredient.py +63 -0
  243. tooluniverse/tools/FDA_get_drug_names_by_alarm.py +63 -0
  244. tooluniverse/tools/FDA_get_drug_names_by_animal_pharmacology_info.py +63 -0
  245. tooluniverse/tools/FDA_get_drug_names_by_application_number_NDC_number.py +59 -0
  246. tooluniverse/tools/FDA_get_drug_names_by_assembly_installation_info.py +63 -0
  247. tooluniverse/tools/FDA_get_drug_names_by_boxed_warning.py +63 -0
  248. tooluniverse/tools/FDA_get_drug_names_by_child_safety_info.py +63 -0
  249. tooluniverse/tools/FDA_get_drug_names_by_clinical_pharmacology.py +63 -0
  250. tooluniverse/tools/FDA_get_drug_names_by_clinical_studies.py +63 -0
  251. tooluniverse/tools/FDA_get_drug_names_by_consulting_doctor_pharmacist_info.py +63 -0
  252. tooluniverse/tools/FDA_get_drug_names_by_contraindications.py +63 -0
  253. tooluniverse/tools/FDA_get_drug_names_by_controlled_substance_DEA_schedule.py +63 -0
  254. tooluniverse/tools/FDA_get_drug_names_by_dear_health_care_provider_letter_info.py +63 -0
  255. tooluniverse/tools/FDA_get_drug_names_by_disposal_info.py +63 -0
  256. tooluniverse/tools/FDA_get_drug_names_by_dosage_forms_and_strengths_info.py +63 -0
  257. tooluniverse/tools/FDA_get_drug_names_by_drug_interactions.py +63 -0
  258. tooluniverse/tools/FDA_get_drug_names_by_effective_time.py +63 -0
  259. tooluniverse/tools/FDA_get_drug_names_by_food_safety_warnings.py +63 -0
  260. tooluniverse/tools/FDA_get_drug_names_by_general_precautions.py +63 -0
  261. tooluniverse/tools/FDA_get_drug_names_by_geriatric_use.py +63 -0
  262. tooluniverse/tools/FDA_get_drug_names_by_health_claim.py +63 -0
  263. tooluniverse/tools/FDA_get_drug_names_by_indication.py +55 -0
  264. tooluniverse/tools/FDA_get_drug_names_by_info_for_nursing_mothers.py +63 -0
  265. tooluniverse/tools/FDA_get_drug_names_by_information_for_owners_or_caregivers.py +63 -0
  266. tooluniverse/tools/FDA_get_drug_names_by_ingredient.py +63 -0
  267. tooluniverse/tools/FDA_get_drug_names_by_instructions_for_use.py +63 -0
  268. tooluniverse/tools/FDA_get_drug_names_by_lab_test_interference.py +63 -0
  269. tooluniverse/tools/FDA_get_drug_names_by_lab_tests.py +63 -0
  270. tooluniverse/tools/FDA_get_drug_names_by_mechanism_of_action.py +63 -0
  271. tooluniverse/tools/FDA_get_drug_names_by_medication_guide.py +63 -0
  272. tooluniverse/tools/FDA_get_drug_names_by_nonclinical_toxicology_info.py +63 -0
  273. tooluniverse/tools/FDA_get_drug_names_by_nonteratogenic_effects.py +63 -0
  274. tooluniverse/tools/FDA_get_drug_names_by_overdosage_info.py +63 -0
  275. tooluniverse/tools/FDA_get_drug_names_by_pediatric_use.py +63 -0
  276. tooluniverse/tools/FDA_get_drug_names_by_pharmacokinetics.py +63 -0
  277. tooluniverse/tools/FDA_get_drug_names_by_population_use.py +63 -0
  278. tooluniverse/tools/FDA_get_drug_names_by_pregnancy_effects_info.py +63 -0
  279. tooluniverse/tools/FDA_get_drug_names_by_residue_warning.py +63 -0
  280. tooluniverse/tools/FDA_get_drug_names_by_risk.py +63 -0
  281. tooluniverse/tools/FDA_get_drug_names_by_route.py +63 -0
  282. tooluniverse/tools/FDA_get_drug_names_by_safe_handling_warning.py +63 -0
  283. tooluniverse/tools/FDA_get_drug_names_by_safety_summary.py +63 -0
  284. tooluniverse/tools/FDA_get_drug_names_by_spl_indexing_data_elements.py +63 -0
  285. tooluniverse/tools/FDA_get_drug_names_by_teratogenic_effects.py +63 -0
  286. tooluniverse/tools/FDA_get_drug_names_by_user_safety_warning.py +63 -0
  287. tooluniverse/tools/FDA_get_drug_names_by_warnings_and_cautions.py +63 -0
  288. tooluniverse/tools/FDA_get_drugs_by_carcinogenic_mutagenic_fertility.py +63 -0
  289. tooluniverse/tools/FDA_get_effective_time_by_drug_name.py +55 -0
  290. tooluniverse/tools/FDA_get_environmental_warning_by_drug_name.py +55 -0
  291. tooluniverse/tools/FDA_get_general_precautions_by_drug_name.py +55 -0
  292. tooluniverse/tools/FDA_get_geriatric_use_info_by_drug_name.py +55 -0
  293. tooluniverse/tools/FDA_get_health_claims_by_drug_name.py +55 -0
  294. tooluniverse/tools/FDA_get_inactive_ingredient_info_by_drug_name.py +55 -0
  295. tooluniverse/tools/FDA_get_indications_by_drug_name.py +55 -0
  296. tooluniverse/tools/FDA_get_info_for_nursing_mothers_by_drug_name.py +55 -0
  297. tooluniverse/tools/FDA_get_info_for_patients_by_drug_name.py +55 -0
  298. tooluniverse/tools/FDA_get_info_on_conditions_for_doctor_consultation_by_drug_name.py +55 -0
  299. tooluniverse/tools/FDA_get_info_on_consulting_doctor_pharmacist_by_drug_name.py +55 -0
  300. tooluniverse/tools/FDA_get_information_for_owners_or_caregivers_by_drug_name.py +55 -0
  301. tooluniverse/tools/FDA_get_ingredients_by_drug_name.py +55 -0
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  581. tooluniverse/tools/get_chem_comp_charge_and_ambiguity.py +46 -0
  582. tooluniverse/tools/get_chembl_webresource_client_info.py +44 -0
  583. tooluniverse/tools/get_citation_info_by_pdb_id.py +46 -0
  584. tooluniverse/tools/get_clair3_info.py +46 -0
  585. tooluniverse/tools/get_clinical_trial_conditions_and_interventions.py +55 -0
  586. tooluniverse/tools/get_clinical_trial_descriptions.py +52 -0
  587. tooluniverse/tools/get_clinical_trial_eligibility_criteria.py +55 -0
  588. tooluniverse/tools/get_clinical_trial_locations.py +52 -0
  589. tooluniverse/tools/get_clinical_trial_outcome_measures.py +52 -0
  590. tooluniverse/tools/get_clinical_trial_references.py +52 -0
  591. tooluniverse/tools/get_clinical_trial_status_and_dates.py +52 -0
  592. tooluniverse/tools/get_cobra_info.py +46 -0
  593. tooluniverse/tools/get_cobrapy_info.py +46 -0
  594. tooluniverse/tools/get_cooler_info.py +49 -0
  595. tooluniverse/tools/get_core_refinement_statistics.py +46 -0
  596. tooluniverse/tools/get_cryosparc_tools_info.py +46 -0
  597. tooluniverse/tools/get_crystal_growth_conditions_by_pdb_id.py +49 -0
  598. tooluniverse/tools/get_crystallization_ph_by_pdb_id.py +46 -0
  599. tooluniverse/tools/get_crystallographic_properties_by_pdb_id.py +49 -0
  600. tooluniverse/tools/get_cupy_info.py +44 -0
  601. tooluniverse/tools/get_cyvcf2_info.py +49 -0
  602. tooluniverse/tools/get_dask_info.py +44 -0
  603. tooluniverse/tools/get_datamol_info.py +44 -0
  604. tooluniverse/tools/get_datashader_info.py +44 -0
  605. tooluniverse/tools/get_deepchem_info.py +49 -0
  606. tooluniverse/tools/get_deeppurpose_info.py +46 -0
  607. tooluniverse/tools/get_deeptools_info.py +46 -0
  608. tooluniverse/tools/get_deepxde_info.py +49 -0
  609. tooluniverse/tools/get_dendropy_info.py +44 -0
  610. tooluniverse/tools/get_descriptastorus_info.py +46 -0
  611. tooluniverse/tools/get_diffdock_info.py +46 -0
  612. tooluniverse/tools/get_dscribe_info.py +49 -0
  613. tooluniverse/tools/get_ec_number_by_entity_id.py +46 -0
  614. tooluniverse/tools/get_elephant_info.py +44 -0
  615. tooluniverse/tools/get_em_3d_fitting_and_reconstruction_details.py +49 -0
  616. tooluniverse/tools/get_emdb_ids_by_pdb_id.py +46 -0
  617. tooluniverse/tools/get_episcanpy_info.py +44 -0
  618. tooluniverse/tools/get_ete3_info.py +44 -0
  619. tooluniverse/tools/get_faiss_info.py +46 -0
  620. tooluniverse/tools/get_fanc_info.py +46 -0
  621. tooluniverse/tools/get_flask_info.py +46 -0
  622. tooluniverse/tools/get_flowio_info.py +46 -0
  623. tooluniverse/tools/get_flowkit_info.py +46 -0
  624. tooluniverse/tools/get_flowutils_info.py +46 -0
  625. tooluniverse/tools/get_freesasa_info.py +44 -0
  626. tooluniverse/tools/get_galpy_info.py +44 -0
  627. tooluniverse/tools/get_gene_name_by_entity_id.py +46 -0
  628. tooluniverse/tools/get_geopandas_info.py +44 -0
  629. tooluniverse/tools/get_gget_info.py +46 -0
  630. tooluniverse/tools/get_googlesearch_python_info.py +46 -0
  631. tooluniverse/tools/get_gseapy_info.py +49 -0
  632. tooluniverse/tools/get_h5py_info.py +46 -0
  633. tooluniverse/tools/get_harmony_pytorch_info.py +46 -0
  634. tooluniverse/tools/get_hmmlearn_info.py +46 -0
  635. tooluniverse/tools/get_holoviews_info.py +44 -0
  636. tooluniverse/tools/get_host_organism_by_pdb_id.py +46 -0
  637. tooluniverse/tools/get_htmd_info.py +44 -0
  638. tooluniverse/tools/get_hyperopt_info.py +49 -0
  639. tooluniverse/tools/get_igraph_info.py +49 -0
  640. tooluniverse/tools/get_imageio_info.py +44 -0
  641. tooluniverse/tools/get_imbalanced_learn_info.py +44 -0
  642. tooluniverse/tools/get_jcvi_info.py +46 -0
  643. tooluniverse/tools/get_joblib_info.py +44 -0
  644. tooluniverse/tools/get_joint_associated_diseases_by_HPO_ID_list.py +55 -0
  645. tooluniverse/tools/get_khmer_info.py +46 -0
  646. tooluniverse/tools/get_kipoiseq_info.py +44 -0
  647. tooluniverse/tools/get_lifelines_info.py +49 -0
  648. tooluniverse/tools/get_ligand_bond_count_by_pdb_id.py +46 -0
  649. tooluniverse/tools/get_ligand_smiles_by_chem_comp_id.py +49 -0
  650. tooluniverse/tools/get_lightgbm_info.py +44 -0
  651. tooluniverse/tools/get_loompy_info.py +46 -0
  652. tooluniverse/tools/get_mageck_info.py +46 -0
  653. tooluniverse/tools/get_matplotlib_info.py +49 -0
  654. tooluniverse/tools/get_mdanalysis_info.py +46 -0
  655. tooluniverse/tools/get_mdtraj_info.py +44 -0
  656. tooluniverse/tools/get_mne_info.py +44 -0
  657. tooluniverse/tools/get_molfeat_info.py +44 -0
  658. tooluniverse/tools/get_molvs_info.py +44 -0
  659. tooluniverse/tools/get_mordred_info.py +44 -0
  660. tooluniverse/tools/get_msprime_info.py +49 -0
  661. tooluniverse/tools/get_mudata_info.py +49 -0
  662. tooluniverse/tools/get_mutation_annotations_by_pdb_id.py +46 -0
  663. tooluniverse/tools/get_neo_info.py +44 -0
  664. tooluniverse/tools/get_netcdf4_info.py +44 -0
  665. tooluniverse/tools/get_networkx_info.py +46 -0
  666. tooluniverse/tools/get_nglview_info.py +44 -0
  667. tooluniverse/tools/get_nilearn_info.py +44 -0
  668. tooluniverse/tools/get_numba_info.py +46 -0
  669. tooluniverse/tools/get_numpy_info.py +46 -0
  670. tooluniverse/tools/get_oligosaccharide_descriptors_by_entity_id.py +49 -0
  671. tooluniverse/tools/get_openbabel_info.py +49 -0
  672. tooluniverse/tools/get_openchem_info.py +46 -0
  673. tooluniverse/tools/get_opencv_info.py +49 -0
  674. tooluniverse/tools/get_openmm_info.py +49 -0
  675. tooluniverse/tools/get_optlang_info.py +46 -0
  676. tooluniverse/tools/get_optuna_info.py +44 -0
  677. tooluniverse/tools/get_palantir_info.py +44 -0
  678. tooluniverse/tools/get_pandas_info.py +49 -0
  679. tooluniverse/tools/get_patsy_info.py +44 -0
  680. tooluniverse/tools/get_pdbfixer_info.py +46 -0
  681. tooluniverse/tools/get_phenotype_by_HPO_ID.py +46 -0
  682. tooluniverse/tools/get_pillow_info.py +44 -0
  683. tooluniverse/tools/get_plantcv_info.py +46 -0
  684. tooluniverse/tools/get_plip_info.py +46 -0
  685. tooluniverse/tools/get_plotly_info.py +44 -0
  686. tooluniverse/tools/get_poliastro_info.py +46 -0
  687. tooluniverse/tools/get_polymer_entity_annotations.py +49 -0
  688. tooluniverse/tools/get_polymer_entity_count_by_pdb_id.py +46 -0
  689. tooluniverse/tools/get_polymer_entity_ids_by_pdb_id.py +46 -0
  690. tooluniverse/tools/get_polymer_entity_type_by_entity_id.py +49 -0
  691. tooluniverse/tools/get_polymer_molecular_weight_by_entity_id.py +49 -0
  692. tooluniverse/tools/get_poretools_info.py +44 -0
  693. tooluniverse/tools/get_prody_info.py +46 -0
  694. tooluniverse/tools/get_protein_classification_by_pdb_id.py +49 -0
  695. tooluniverse/tools/get_protein_metadata_by_pdb_id.py +46 -0
  696. tooluniverse/tools/get_pubchempy_info.py +44 -0
  697. tooluniverse/tools/get_pybedtools_info.py +49 -0
  698. tooluniverse/tools/get_pybigwig_info.py +46 -0
  699. tooluniverse/tools/get_pydeseq2_info.py +46 -0
  700. tooluniverse/tools/get_pyensembl_info.py +44 -0
  701. tooluniverse/tools/get_pyephem_info.py +44 -0
  702. tooluniverse/tools/get_pyfaidx_info.py +49 -0
  703. tooluniverse/tools/get_pyfasta_info.py +44 -0
  704. tooluniverse/tools/get_pykalman_info.py +46 -0
  705. tooluniverse/tools/get_pyliftover_info.py +49 -0
  706. tooluniverse/tools/get_pymassspec_info.py +46 -0
  707. tooluniverse/tools/get_pymed_info.py +46 -0
  708. tooluniverse/tools/get_pymzml_info.py +46 -0
  709. tooluniverse/tools/get_pypdf2_info.py +46 -0
  710. tooluniverse/tools/get_pyranges_info.py +49 -0
  711. tooluniverse/tools/get_pyrosetta_info.py +44 -0
  712. tooluniverse/tools/get_pysam_info.py +46 -0
  713. tooluniverse/tools/get_pyscenic_info.py +46 -0
  714. tooluniverse/tools/get_pyscf_info.py +46 -0
  715. tooluniverse/tools/get_pyscreener_info.py +46 -0
  716. tooluniverse/tools/get_pytdc_info.py +46 -0
  717. tooluniverse/tools/get_python_libsbml_info.py +46 -0
  718. tooluniverse/tools/get_pytorch_info.py +49 -0
  719. tooluniverse/tools/get_pyvcf_info.py +44 -0
  720. tooluniverse/tools/get_pyvis_info.py +44 -0
  721. tooluniverse/tools/get_qutip_info.py +44 -0
  722. tooluniverse/tools/get_rasterio_info.py +44 -0
  723. tooluniverse/tools/get_rdkit_info.py +46 -0
  724. tooluniverse/tools/get_refinement_resolution_by_pdb_id.py +49 -0
  725. tooluniverse/tools/get_release_deposit_dates_by_pdb_id.py +49 -0
  726. tooluniverse/tools/get_reportlab_info.py +49 -0
  727. tooluniverse/tools/get_requests_info.py +49 -0
  728. tooluniverse/tools/get_ruptures_info.py +46 -0
  729. tooluniverse/tools/get_scanorama_info.py +44 -0
  730. tooluniverse/tools/get_scanpy_info.py +49 -0
  731. tooluniverse/tools/get_schnetpack_info.py +49 -0
  732. tooluniverse/tools/get_scholarly_info.py +46 -0
  733. tooluniverse/tools/get_scikit_bio_info.py +49 -0
  734. tooluniverse/tools/get_scikit_image_info.py +46 -0
  735. tooluniverse/tools/get_scikit_learn_info.py +49 -0
  736. tooluniverse/tools/get_scipy_info.py +46 -0
  737. tooluniverse/tools/get_scrublet_info.py +49 -0
  738. tooluniverse/tools/get_scvelo_info.py +49 -0
  739. tooluniverse/tools/get_scvi_tools_info.py +44 -0
  740. tooluniverse/tools/get_seaborn_info.py +49 -0
  741. tooluniverse/tools/get_sequence_by_pdb_id.py +46 -0
  742. tooluniverse/tools/get_sequence_lengths_by_pdb_id.py +46 -0
  743. tooluniverse/tools/get_sequence_positional_features_by_instance_id.py +49 -0
  744. tooluniverse/tools/get_skopt_info.py +44 -0
  745. tooluniverse/tools/get_souporcell_info.py +46 -0
  746. tooluniverse/tools/get_source_organism_by_pdb_id.py +46 -0
  747. tooluniverse/tools/get_space_group_by_pdb_id.py +46 -0
  748. tooluniverse/tools/get_statsmodels_info.py +49 -0
  749. tooluniverse/tools/get_structure_determination_software_by_pdb_id.py +49 -0
  750. tooluniverse/tools/get_structure_title_by_pdb_id.py +46 -0
  751. tooluniverse/tools/get_structure_validation_metrics_by_pdb_id.py +49 -0
  752. tooluniverse/tools/get_sunpy_info.py +44 -0
  753. tooluniverse/tools/get_sympy_info.py +46 -0
  754. tooluniverse/tools/get_target_cofactor_info.py +46 -0
  755. tooluniverse/tools/get_taxonomy_by_pdb_id.py +46 -0
  756. tooluniverse/tools/get_tiledb_info.py +46 -0
  757. tooluniverse/tools/get_tiledbsoma_info.py +46 -0
  758. tooluniverse/tools/get_torch_geometric_info.py +49 -0
  759. tooluniverse/tools/get_tqdm_info.py +46 -0
  760. tooluniverse/tools/get_trackpy_info.py +46 -0
  761. tooluniverse/tools/get_tskit_info.py +46 -0
  762. tooluniverse/tools/get_umap_learn_info.py +49 -0
  763. tooluniverse/tools/get_uniprot_accession_by_entity_id.py +49 -0
  764. tooluniverse/tools/get_velocyto_info.py +44 -0
  765. tooluniverse/tools/get_viennarna_info.py +49 -0
  766. tooluniverse/tools/get_webpage_text_from_url.py +52 -0
  767. tooluniverse/tools/get_webpage_title.py +49 -0
  768. tooluniverse/tools/get_xarray_info.py +44 -0
  769. tooluniverse/tools/get_xesmf_info.py +44 -0
  770. tooluniverse/tools/get_xgboost_info.py +44 -0
  771. tooluniverse/tools/get_zarr_info.py +44 -0
  772. tooluniverse/tools/gnomAD_query_variant.py +52 -0
  773. tooluniverse/tools/gwas_get_association_by_id.py +49 -0
  774. tooluniverse/tools/gwas_get_associations_for_snp.py +67 -0
  775. tooluniverse/tools/gwas_get_associations_for_study.py +55 -0
  776. tooluniverse/tools/gwas_get_associations_for_trait.py +55 -0
  777. tooluniverse/tools/gwas_get_snp_by_id.py +46 -0
  778. tooluniverse/tools/gwas_get_snps_for_gene.py +55 -0
  779. tooluniverse/tools/gwas_get_studies_for_trait.py +75 -0
  780. tooluniverse/tools/gwas_get_study_by_id.py +46 -0
  781. tooluniverse/tools/gwas_get_variants_for_trait.py +55 -0
  782. tooluniverse/tools/gwas_search_associations.py +75 -0
  783. tooluniverse/tools/gwas_search_snps.py +63 -0
  784. tooluniverse/tools/gwas_search_studies.py +75 -0
  785. tooluniverse/tools/humanbase_ppi_analysis.py +67 -0
  786. tooluniverse/tools/mesh_get_subjects_by_pharmacological_action.py +63 -0
  787. tooluniverse/tools/mesh_get_subjects_by_subject_id.py +63 -0
  788. tooluniverse/tools/mesh_get_subjects_by_subject_name.py +63 -0
  789. tooluniverse/tools/mesh_get_subjects_by_subject_scope_or_definition.py +63 -0
  790. tooluniverse/tools/odphp_itemlist.py +49 -0
  791. tooluniverse/tools/odphp_myhealthfinder.py +67 -0
  792. tooluniverse/tools/odphp_outlink_fetch.py +59 -0
  793. tooluniverse/tools/odphp_topicsearch.py +67 -0
  794. tooluniverse/tools/openalex_literature_search.py +67 -0
  795. tooluniverse/tools/reactome_disease_target_score.py +52 -0
  796. tooluniverse/tools/search_clinical_trials.py +67 -0
  797. tooluniverse/tools/visualize_molecule_2d.py +83 -0
  798. tooluniverse/tools/visualize_molecule_3d.py +91 -0
  799. tooluniverse/tools/visualize_protein_structure_3d.py +79 -0
  800. tooluniverse/ucsc_tool.py +60 -0
  801. tooluniverse/unified_guideline_tools.py +2328 -0
  802. tooluniverse/unpaywall_tool.py +0 -1
  803. tooluniverse/utils.py +122 -6
  804. tooluniverse/visualization_tool.py +897 -0
  805. tooluniverse/wikidata_sparql_tool.py +1 -2
  806. tooluniverse/zenodo_tool.py +3 -4
  807. {tooluniverse-1.0.6.dist-info → tooluniverse-1.0.8.dist-info}/METADATA +19 -4
  808. tooluniverse-1.0.8.dist-info/RECORD +891 -0
  809. {tooluniverse-1.0.6.dist-info → tooluniverse-1.0.8.dist-info}/entry_points.txt +3 -0
  810. tooluniverse/test/list_azure_openai_models.py +0 -210
  811. tooluniverse/test/mcp_server_test.py +0 -0
  812. tooluniverse/test/test_admetai_tool.py +0 -370
  813. tooluniverse/test/test_agentic_tool.py +0 -129
  814. tooluniverse/test/test_agentic_tool_azure_models.py +0 -91
  815. tooluniverse/test/test_alphafold_tool.py +0 -108
  816. tooluniverse/test/test_api_key_validation_min.py +0 -64
  817. tooluniverse/test/test_chem_tool.py +0 -37
  818. tooluniverse/test/test_claude_sdk.py +0 -93
  819. tooluniverse/test/test_compose_lieraturereview.py +0 -63
  820. tooluniverse/test/test_compose_tool.py +0 -448
  821. tooluniverse/test/test_dailymed.py +0 -69
  822. tooluniverse/test/test_dataset_tool.py +0 -200
  823. tooluniverse/test/test_disease_target_score.py +0 -56
  824. tooluniverse/test/test_drugbank_filter_examples.py +0 -179
  825. tooluniverse/test/test_efo.py +0 -31
  826. tooluniverse/test/test_enrichr_tool.py +0 -21
  827. tooluniverse/test/test_europe_pmc_tool.py +0 -20
  828. tooluniverse/test/test_fda_adv.py +0 -95
  829. tooluniverse/test/test_fda_drug_labeling.py +0 -91
  830. tooluniverse/test/test_gene_ontology_tools.py +0 -66
  831. tooluniverse/test/test_global_fallback.py +0 -288
  832. tooluniverse/test/test_gwas_tool.py +0 -139
  833. tooluniverse/test/test_hooks_direct.py +0 -219
  834. tooluniverse/test/test_hpa.py +0 -625
  835. tooluniverse/test/test_humanbase_tool.py +0 -20
  836. tooluniverse/test/test_idmap_tools.py +0 -61
  837. tooluniverse/test/test_list_built_in_tools.py +0 -33
  838. tooluniverse/test/test_mcp_server.py +0 -211
  839. tooluniverse/test/test_mcp_tool.py +0 -247
  840. tooluniverse/test/test_medlineplus.py +0 -220
  841. tooluniverse/test/test_odphp_tool.py +0 -166
  842. tooluniverse/test/test_openalex_tool.py +0 -32
  843. tooluniverse/test/test_openrouter_client.py +0 -288
  844. tooluniverse/test/test_opentargets.py +0 -28
  845. tooluniverse/test/test_pubchem_tool.py +0 -116
  846. tooluniverse/test/test_pubtator_tool.py +0 -37
  847. tooluniverse/test/test_rcsb_pdb_tool.py +0 -86
  848. tooluniverse/test/test_reactome.py +0 -54
  849. tooluniverse/test/test_semantic_scholar_tool.py +0 -24
  850. tooluniverse/test/test_software_tools.py +0 -147
  851. tooluniverse/test/test_stdio_hooks.py +0 -285
  852. tooluniverse/test/test_tool_description_optimizer.py +0 -49
  853. tooluniverse/test/test_tool_finder.py +0 -26
  854. tooluniverse/test/test_tool_finder_llm.py +0 -252
  855. tooluniverse/test/test_tools_find.py +0 -195
  856. tooluniverse/test/test_uniprot_tools.py +0 -74
  857. tooluniverse/test/test_uspto_tool.py +0 -72
  858. tooluniverse/test/test_xml_tool.py +0 -113
  859. tooluniverse-1.0.6.dist-info/RECORD +0 -230
  860. {tooluniverse-1.0.6.dist-info → tooluniverse-1.0.8.dist-info}/WHEEL +0 -0
  861. {tooluniverse-1.0.6.dist-info → tooluniverse-1.0.8.dist-info}/licenses/LICENSE +0 -0
  862. {tooluniverse-1.0.6.dist-info → tooluniverse-1.0.8.dist-info}/top_level.txt +0 -0
@@ -0,0 +1,63 @@
1
+ import requests
2
+ import json
3
+ from .base_tool import BaseTool
4
+ from .tool_registry import register_tool
5
+
6
+
7
+ @register_tool("GnomadTool")
8
+ class GnomadTool(BaseTool):
9
+ """
10
+ Local tool wrapper for gnomAD GraphQL API.
11
+ Queries variant information including allele frequencies.
12
+ """
13
+
14
+ def __init__(self, tool_config):
15
+ super().__init__(tool_config)
16
+ self.base = "https://gnomad.broadinstitute.org/api"
17
+ self.session = requests.Session()
18
+ self.session.headers.update({"Content-Type": "application/json"})
19
+
20
+ def run(self, arguments):
21
+ variant_id = arguments.get("variant_id")
22
+ dataset = arguments.get("dataset", "gnomad_r4")
23
+
24
+ if not variant_id:
25
+ return {"error": "Missing required parameter: variant_id"}
26
+
27
+ # GraphQL query for variant with genome frequencies
28
+ query = """
29
+ query($variant: String!, $dataset: DatasetId!) {
30
+ variant(variantId: $variant, dataset: $dataset) {
31
+ variantId
32
+ genome {
33
+ ac
34
+ an
35
+ af
36
+ }
37
+ }
38
+ }
39
+ """
40
+
41
+ payload = {
42
+ "query": query,
43
+ "variables": {
44
+ "variant": variant_id,
45
+ "dataset": dataset,
46
+ },
47
+ }
48
+
49
+ resp = self.session.post(self.base, data=json.dumps(payload), timeout=30)
50
+ resp.raise_for_status()
51
+ data = resp.json()
52
+
53
+ if "errors" in data:
54
+ return {"error": f"GraphQL errors: {data['errors']}"}
55
+
56
+ variant = data.get("data", {}).get("variant")
57
+ if not variant:
58
+ return {"error": "Variant not found"}
59
+
60
+ return {
61
+ "variantId": variant.get("variantId"),
62
+ "genome": variant.get("genome", {}),
63
+ }
tooluniverse/hal_tool.py CHANGED
@@ -51,7 +51,7 @@ class HALTool(BaseTool):
51
51
  docs = data.get("response", {}).get("docs", [])
52
52
  results = []
53
53
  for d in docs:
54
- title = (d.get("title_s") or [None])
54
+ title = d.get("title_s") or [None]
55
55
  if isinstance(title, list):
56
56
  title = title[0]
57
57
  authors = d.get("authFullName_s") or []
@@ -328,110 +328,6 @@ class AzureOpenAIClient(BaseLLMClient):
328
328
  self.logger.error("Max retries exceeded. Unable to complete the request.")
329
329
  return None
330
330
 
331
- def infer_stream(
332
- self,
333
- messages: List[Dict[str, str]],
334
- temperature: Optional[float],
335
- max_tokens: Optional[int],
336
- return_json: bool,
337
- custom_format: Any = None,
338
- max_retries: int = 5,
339
- retry_delay: int = 5,
340
- ):
341
- if return_json or custom_format is not None:
342
- yield from super().infer_stream(
343
- messages,
344
- temperature,
345
- max_tokens,
346
- return_json,
347
- custom_format,
348
- max_retries,
349
- retry_delay,
350
- )
351
- return
352
-
353
- retries = 0
354
- eff_max = (
355
- max_tokens
356
- if max_tokens is not None
357
- else self._resolve_default_max_tokens(self.model_name)
358
- )
359
-
360
- while retries < max_retries:
361
- try:
362
- kwargs: Dict[str, Any] = {
363
- "model": self.model_name,
364
- "messages": messages,
365
- "stream": True,
366
- }
367
- if temperature is not None:
368
- kwargs["temperature"] = temperature
369
- if eff_max is not None:
370
- kwargs["max_tokens"] = eff_max
371
-
372
- stream = self.client.chat.completions.create(**kwargs)
373
- for chunk in stream:
374
- text = AzureOpenAIClient._extract_text_from_chunk(chunk) # type: ignore[attr-defined]
375
- if text:
376
- yield text
377
- return
378
- except self._openai.RateLimitError: # type: ignore[attr-defined]
379
- self.logger.warning(
380
- f"OpenRouter streaming rate limit hit. Retrying in {retry_delay} seconds..."
381
- )
382
- retries += 1
383
- time.sleep(retry_delay * retries)
384
- except Exception as e: # noqa: BLE001
385
- self.logger.error(f"OpenRouter streaming error: {e}")
386
- break
387
-
388
- yield from super().infer_stream(
389
- messages,
390
- temperature,
391
- max_tokens,
392
- return_json,
393
- custom_format,
394
- max_retries,
395
- retry_delay,
396
- )
397
-
398
- @staticmethod
399
- def _extract_text_from_chunk(chunk) -> Optional[str]:
400
- try:
401
- choices = getattr(chunk, "choices", None)
402
- except Exception:
403
- choices = None
404
- if not choices:
405
- return None
406
-
407
- first_choice = choices[0]
408
- delta = getattr(first_choice, "delta", None)
409
- if delta is None and isinstance(first_choice, dict):
410
- delta = first_choice.get("delta")
411
- if delta is None:
412
- return None
413
-
414
- content = getattr(delta, "content", None)
415
- if content is None and isinstance(delta, dict):
416
- content = delta.get("content")
417
- if not content:
418
- return None
419
-
420
- if isinstance(content, str):
421
- return content
422
-
423
- if isinstance(content, list):
424
- fragments: List[str] = []
425
- for item in content:
426
- text = getattr(item, "text", None)
427
- if text is None and isinstance(item, dict):
428
- text = item.get("text")
429
- if text:
430
- fragments.append(text)
431
- return "".join(fragments) if fragments else None
432
-
433
- return None
434
-
435
331
  def infer_stream(
436
332
  self,
437
333
  messages: List[Dict[str, str]],
@@ -663,11 +559,14 @@ class OpenRouterClient(BaseLLMClient):
663
559
 
664
560
  # Default model limits based on latest OpenRouter offerings
665
561
  DEFAULT_MODEL_LIMITS: Dict[str, Dict[str, int]] = {
666
- "openai/gpt-5": {"max_output": 128_000, "context_window": 400_000},
562
+ "openai/gpt-5": {"max_output": 128_000, "context_window": 400_000},
667
563
  "openai/gpt-5-codex": {"max_output": 128_000, "context_window": 400_000},
668
564
  "google/gemini-2.5-flash": {"max_output": 65_536, "context_window": 1_000_000},
669
565
  "google/gemini-2.5-pro": {"max_output": 65_536, "context_window": 1_000_000},
670
- "anthropic/claude-sonnet-4.5": {"max_output": 16_384, "context_window": 1_000_000},
566
+ "anthropic/claude-sonnet-4.5": {
567
+ "max_output": 16_384,
568
+ "context_window": 1_000_000,
569
+ },
671
570
  }
672
571
 
673
572
  def __init__(self, model_id: str, logger):
@@ -676,7 +575,7 @@ class OpenRouterClient(BaseLLMClient):
676
575
  import openai as _openai # type: ignore
677
576
  except Exception as e: # pragma: no cover
678
577
  raise RuntimeError("openai client is not available") from e
679
-
578
+
680
579
  self._OpenAI = _OpenAI
681
580
  self._openai = _openai
682
581
  self.model_name = model_id
@@ -685,14 +584,14 @@ class OpenRouterClient(BaseLLMClient):
685
584
  api_key = os.getenv("OPENROUTER_API_KEY")
686
585
  if not api_key:
687
586
  raise ValueError("OPENROUTER_API_KEY not set")
688
-
587
+
689
588
  # Optional headers for OpenRouter
690
589
  default_headers = {}
691
590
  if site_url := os.getenv("OPENROUTER_SITE_URL"):
692
591
  default_headers["HTTP-Referer"] = site_url
693
592
  if site_name := os.getenv("OPENROUTER_SITE_NAME"):
694
593
  default_headers["X-Title"] = site_name
695
-
594
+
696
595
  self.client = self._OpenAI(
697
596
  base_url="https://openrouter.ai/api/v1",
698
597
  api_key=api_key,
@@ -731,13 +630,13 @@ class OpenRouterClient(BaseLLMClient):
731
630
  mapping = _json.loads(mapping_raw)
732
631
  except Exception:
733
632
  mapping = {}
734
-
633
+
735
634
  if model_id in mapping:
736
635
  try:
737
636
  return int(mapping[model_id])
738
637
  except Exception:
739
638
  pass
740
-
639
+
741
640
  # Check for prefix match
742
641
  for k, v in mapping.items():
743
642
  try:
@@ -745,11 +644,11 @@ class OpenRouterClient(BaseLLMClient):
745
644
  return int(v)
746
645
  except Exception:
747
646
  continue
748
-
647
+
749
648
  # Next: built-in/default-limits map
750
649
  if model_id in self._default_limits:
751
650
  return int(self._default_limits[model_id].get("max_output", 0)) or None
752
-
651
+
753
652
  # Check for prefix match in default limits
754
653
  for k, v in self._default_limits.items():
755
654
  try:
@@ -757,7 +656,7 @@ class OpenRouterClient(BaseLLMClient):
757
656
  return int(v.get("max_output", 0)) or None
758
657
  except Exception:
759
658
  continue
760
-
659
+
761
660
  return None
762
661
 
763
662
  def test_api(self) -> None:
@@ -765,7 +664,7 @@ class OpenRouterClient(BaseLLMClient):
765
664
  test_messages = [{"role": "user", "content": "ping"}]
766
665
  token_attempts = [1, 4, 16, 32]
767
666
  last_error: Optional[Exception] = None
768
-
667
+
769
668
  for tok in token_attempts:
770
669
  try:
771
670
  self.client.chat.completions.create(
@@ -785,7 +684,7 @@ class OpenRouterClient(BaseLLMClient):
785
684
  ) and tok != token_attempts[-1]:
786
685
  continue
787
686
  break
788
-
687
+
789
688
  if last_error:
790
689
  raise ValueError(f"OpenRouter API test failed: {last_error}")
791
690
  raise ValueError("OpenRouter API test failed: unknown error")
@@ -807,39 +706,39 @@ class OpenRouterClient(BaseLLMClient):
807
706
  if custom_format is not None
808
707
  else self.client.chat.completions.create
809
708
  )
810
-
709
+
811
710
  response_format = (
812
711
  custom_format
813
712
  if custom_format is not None
814
713
  else ({"type": "json_object"} if return_json else None)
815
714
  )
816
-
715
+
817
716
  eff_max = (
818
717
  max_tokens
819
718
  if max_tokens is not None
820
719
  else self._resolve_default_max_tokens(self.model_name)
821
720
  )
822
-
721
+
823
722
  while retries < max_retries:
824
723
  try:
825
724
  kwargs: Dict[str, Any] = {
826
725
  "model": self.model_name,
827
726
  "messages": messages,
828
727
  }
829
-
728
+
830
729
  if response_format is not None:
831
730
  kwargs["response_format"] = response_format
832
731
  if temperature is not None:
833
732
  kwargs["temperature"] = temperature
834
733
  if eff_max is not None:
835
734
  kwargs["max_tokens"] = eff_max
836
-
735
+
837
736
  resp = call_fn(**kwargs)
838
-
737
+
839
738
  if custom_format is not None:
840
739
  return resp.choices[0].message.parsed.model_dump()
841
740
  return resp.choices[0].message.content
842
-
741
+
843
742
  except self._openai.RateLimitError: # type: ignore[attr-defined]
844
743
  self.logger.warning(
845
744
  f"Rate limit exceeded. Retrying in {retry_delay} seconds..."
@@ -849,8 +748,86 @@ class OpenRouterClient(BaseLLMClient):
849
748
  except Exception as e: # noqa: BLE001
850
749
  self.logger.error(f"OpenRouter error: {e}")
851
750
  import traceback
751
+
852
752
  traceback.print_exc()
853
753
  break
854
-
754
+
855
755
  self.logger.error("Max retries exceeded. Unable to complete the request.")
856
756
  return None
757
+
758
+
759
+ class VLLMClient(BaseLLMClient):
760
+ def __init__(self, model_name: str, server_url: str, logger):
761
+ try:
762
+ from openai import OpenAI
763
+ except Exception as e:
764
+ raise RuntimeError("openai package not available for vLLM client") from e
765
+
766
+ if not server_url:
767
+ raise ValueError("VLLM_SERVER_URL must be provided")
768
+
769
+ self.model_name = model_name
770
+ # Ensure server_url ends with /v1 for OpenAI-compatible API
771
+ if not server_url.endswith("/v1"):
772
+ server_url = server_url.rstrip("/") + "/v1"
773
+ self.server_url = server_url
774
+ self.logger = logger
775
+
776
+ self.client = OpenAI(
777
+ api_key="EMPTY",
778
+ base_url=self.server_url,
779
+ )
780
+
781
+ def test_api(self) -> None:
782
+ test_messages = [{"role": "user", "content": "ping"}]
783
+ try:
784
+ self.client.chat.completions.create(
785
+ model=self.model_name,
786
+ messages=test_messages,
787
+ max_tokens=8,
788
+ temperature=0,
789
+ )
790
+ except Exception as e:
791
+ raise ValueError(f"vLLM API test failed: {e}")
792
+
793
+ def infer(
794
+ self,
795
+ messages: List[Dict[str, str]],
796
+ temperature: Optional[float],
797
+ max_tokens: Optional[int],
798
+ return_json: bool,
799
+ custom_format: Any = None,
800
+ max_retries: int = 5,
801
+ retry_delay: int = 5,
802
+ ) -> Optional[str]:
803
+ if custom_format is not None:
804
+ self.logger.warning("vLLM does not support custom format, ignoring")
805
+
806
+ retries = 0
807
+ while retries < max_retries:
808
+ try:
809
+ kwargs: Dict[str, Any] = {
810
+ "model": self.model_name,
811
+ "messages": messages,
812
+ }
813
+
814
+ if temperature is not None:
815
+ kwargs["temperature"] = temperature
816
+
817
+ if max_tokens is not None:
818
+ kwargs["max_tokens"] = max_tokens
819
+
820
+ if return_json:
821
+ kwargs["response_format"] = {"type": "json_object"}
822
+
823
+ resp = self.client.chat.completions.create(**kwargs)
824
+ return resp.choices[0].message.content
825
+
826
+ except Exception as e:
827
+ self.logger.error(f"vLLM error: {e}")
828
+ retries += 1
829
+ if retries < max_retries:
830
+ time.sleep(retry_delay * retries)
831
+
832
+ self.logger.error("Max retries exceeded for vLLM request")
833
+ return None
@@ -0,0 +1,159 @@
1
+ """
2
+ MarkItDown Tool for ToolUniverse
3
+
4
+ Simple implementation following Microsoft's official MCP pattern.
5
+ Supports http:, https:, file:, data: URIs.
6
+ """
7
+
8
+ import os
9
+ import subprocess
10
+ import sys
11
+ import urllib.parse
12
+ import urllib.request
13
+ import tempfile
14
+ from typing import Dict, Any
15
+ from .base_tool import BaseTool
16
+ from .tool_registry import register_tool
17
+
18
+
19
+ @register_tool("MarkItDownTool")
20
+ class MarkItDownTool(BaseTool):
21
+ """MarkItDown tool for converting files to Markdown."""
22
+
23
+ def __init__(self, tool_config):
24
+ super().__init__(tool_config)
25
+ self.tool_name = tool_config.get("name", "MarkItDownTool")
26
+
27
+ def run(self, arguments: Dict[str, Any]) -> Dict[str, Any]:
28
+ """Execute MarkItDown tool."""
29
+ try:
30
+ return self._convert_to_markdown(arguments)
31
+ except Exception as e:
32
+ return {"error": str(e)}
33
+
34
+ def _convert_to_markdown(self, arguments: Dict[str, Any]) -> Dict[str, Any]:
35
+ """Convert a resource described by URI to Markdown using markitdown CLI."""
36
+ uri = arguments.get("uri")
37
+ output_path = arguments.get("output_path")
38
+ enable_plugins = arguments.get("enable_plugins", False)
39
+
40
+ if not uri:
41
+ return {"error": "URI is required"}
42
+
43
+ try:
44
+ # Parse URI
45
+ parsed_uri = urllib.parse.urlparse(uri)
46
+ scheme = parsed_uri.scheme.lower()
47
+
48
+ # Handle different URI schemes
49
+ if scheme in ["http", "https"]:
50
+ # Download from URL
51
+ temp_file = self._download_from_url(uri)
52
+ if not temp_file:
53
+ return {"error": f"Failed to download from URL: {uri}"}
54
+ input_path = temp_file
55
+ cleanup_temp = True
56
+
57
+ elif scheme == "file":
58
+ # Local file
59
+ file_path = urllib.request.url2pathname(parsed_uri.path)
60
+ if not os.path.exists(file_path):
61
+ return {"error": f"File not found: {file_path}"}
62
+ input_path = file_path
63
+ cleanup_temp = False
64
+
65
+ elif scheme == "data":
66
+ # Data URI
67
+ temp_file = self._handle_data_uri(uri)
68
+ if not temp_file:
69
+ return {"error": f"Failed to process data URI: {uri}"}
70
+ input_path = temp_file
71
+ cleanup_temp = True
72
+
73
+ else:
74
+ return {
75
+ "error": f"Unsupported URI scheme: {scheme}. Supported schemes: http, https, file, data"
76
+ }
77
+
78
+ # Build markitdown command
79
+ cmd = [sys.executable, "-m", "markitdown", input_path]
80
+ if enable_plugins:
81
+ cmd.append("--use-plugins")
82
+ if output_path:
83
+ cmd.extend(["-o", output_path])
84
+
85
+ # Execute command
86
+ result = subprocess.run(cmd, capture_output=True, text=True, timeout=60)
87
+
88
+ if result.returncode != 0:
89
+ error_msg = f"MarkItDown failed: {result.stderr}"
90
+ if cleanup_temp and os.path.exists(input_path):
91
+ os.unlink(input_path)
92
+ return {"error": error_msg}
93
+
94
+ # Get markdown content
95
+ if output_path and os.path.exists(output_path):
96
+ with open(output_path, "r", encoding="utf-8") as f:
97
+ markdown_content = f.read()
98
+ else:
99
+ markdown_content = result.stdout
100
+
101
+ # Clean up temporary file if needed
102
+ if cleanup_temp and os.path.exists(input_path):
103
+ os.unlink(input_path)
104
+
105
+ # Prepare response
106
+ response = {
107
+ "markdown_content": markdown_content,
108
+ "file_info": {
109
+ "original_uri": uri,
110
+ "uri_scheme": scheme,
111
+ "output_file": output_path if output_path else None,
112
+ },
113
+ }
114
+
115
+ # If no output_path specified, also return the content as a string for convenience
116
+ if not output_path:
117
+ response["content"] = markdown_content
118
+
119
+ return response
120
+
121
+ except Exception as e:
122
+ return {"error": f"URI processing failed: {str(e)}"}
123
+
124
+ def _download_from_url(self, url: str) -> str:
125
+ """Download content from URL to temporary file."""
126
+ try:
127
+ with urllib.request.urlopen(url, timeout=30) as response:
128
+ content = response.read()
129
+
130
+ # Create temporary file
131
+ with tempfile.NamedTemporaryFile(delete=False) as temp_file:
132
+ temp_file.write(content)
133
+ return temp_file.name
134
+ except Exception:
135
+ return None
136
+
137
+ def _handle_data_uri(self, data_uri: str) -> str:
138
+ """Handle data URI and save to temporary file."""
139
+ try:
140
+ # Parse data URI: data:[<mediatype>][;base64],<data>
141
+ if "," not in data_uri:
142
+ return None
143
+
144
+ header, data = data_uri.split(",", 1)
145
+
146
+ # Check if base64 encoded
147
+ if ";base64" in header:
148
+ import base64
149
+
150
+ content = base64.b64decode(data)
151
+ else:
152
+ content = data.encode("utf-8")
153
+
154
+ # Create temporary file
155
+ with tempfile.NamedTemporaryFile(delete=False) as temp_file:
156
+ temp_file.write(content)
157
+ return temp_file.name
158
+ except Exception:
159
+ return None
@@ -26,18 +26,23 @@ class BaseMCPClient:
26
26
 
27
27
  def __init__(self, server_url: str, transport: str = "http", timeout: int = 30):
28
28
  self.server_url = os.path.expandvars(server_url)
29
- self.transport = transport
29
+ # Normalize transport for backward compatibility: treat 'stdio' as HTTP
30
+ normalized_transport = (
31
+ transport.lower() if isinstance(transport, str) else "http"
32
+ )
33
+ if normalized_transport == "stdio":
34
+ normalized_transport = "http"
35
+ self.transport = normalized_transport
30
36
  self.timeout = timeout
31
37
  self.session = None
32
38
  self.mcp_session_id = None
33
39
  self._initialized = False
34
40
 
35
- # Validate transport
41
+ # Validate transport (accept 'stdio' via normalization above)
36
42
  supported_transports = ["http", "websocket"]
37
43
  if self.transport not in supported_transports:
38
- raise ValueError(
39
- f"Invalid transport '{self.transport}'. Supported: {supported_transports}"
40
- )
44
+ # Keep message concise to satisfy line length rules
45
+ raise ValueError("Invalid transport")
41
46
 
42
47
  async def _ensure_session(self):
43
48
  """Ensure HTTP session is available for HTTP transport"""
@@ -348,7 +348,10 @@ def _start_server_for_port(port: int, **kwargs):
348
348
  try:
349
349
  # Enable stateless mode for MCPAutoLoaderTool compatibility
350
350
  server.run_simple(
351
- transport=config["transport"], host=config["host"], port=port, stateless_http=True
351
+ transport=config["transport"],
352
+ host=config["host"],
353
+ port=port,
354
+ stateless_http=True,
352
355
  )
353
356
  except Exception as e:
354
357
  print(f"❌ Error running MCP server on port {port}: {e}")
@@ -34,13 +34,15 @@ class MedRxivTool(BaseTool):
34
34
  # Format: /medrxiv/{start_date}/{end_date}/{cursor}/json
35
35
  from datetime import datetime, timedelta
36
36
 
37
- # Search last 30 days
37
+ # Search last 365 days to get more comprehensive results
38
38
  end_date = datetime.now()
39
- start_date = end_date - timedelta(days=30)
39
+ start_date = end_date - timedelta(days=365)
40
40
 
41
- url = (f"{self.base_url}/medrxiv/"
42
- f"{start_date.strftime('%Y-%m-%d')}/"
43
- f"{end_date.strftime('%Y-%m-%d')}/0/json")
41
+ url = (
42
+ f"{self.base_url}/medrxiv/"
43
+ f"{start_date.strftime('%Y-%m-%d')}/"
44
+ f"{end_date.strftime('%Y-%m-%d')}/0/json"
45
+ )
44
46
 
45
47
  try:
46
48
  resp = requests.get(url, timeout=20)
@@ -78,19 +80,36 @@ class MedRxivTool(BaseTool):
78
80
  doi = item.get("doi")
79
81
  url = f"https://www.medrxiv.org/content/{doi}" if doi else None
80
82
 
81
- # Filter by query if provided
82
- if query and query.lower() not in (title or "").lower():
83
- continue
83
+ # Filter by query if provided - search in both title and abstract
84
+ if query:
85
+ title_match = query.lower() in (title or "").lower()
86
+ abstract_match = (
87
+ query.lower() in (item.get("abstract", "") or "").lower()
88
+ )
89
+ if not (title_match or abstract_match):
90
+ continue
84
91
 
85
92
  results.append(
86
93
  {
87
- "title": title,
88
- "authors": authors,
94
+ "title": title or "Title not available",
95
+ "authors": (
96
+ authors if authors else "Author information not available"
97
+ ),
89
98
  "year": year,
90
- "doi": doi,
91
- "url": url,
92
- "abstract": item.get("abstract", ""),
99
+ "doi": doi or "DOI not available",
100
+ "url": url or "URL not available",
101
+ "abstract": item.get("abstract", "Abstract not available"),
93
102
  "source": "medRxiv",
103
+ "data_quality": {
104
+ "has_abstract": bool(
105
+ item.get("abstract")
106
+ and item.get("abstract") != "Abstract not available"
107
+ ),
108
+ "has_authors": bool(authors),
109
+ "has_year": bool(year),
110
+ "has_doi": bool(doi),
111
+ "has_url": bool(url),
112
+ },
94
113
  }
95
114
  )
96
115