tooluniverse 1.0.6__py3-none-any.whl → 1.0.8__py3-none-any.whl
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- tooluniverse/__init__.py +56 -10
- tooluniverse/admetai_tool.py +8 -4
- tooluniverse/agentic_tool.py +40 -4
- tooluniverse/arxiv_tool.py +2 -6
- tooluniverse/base_tool.py +210 -25
- tooluniverse/biogrid_tool.py +118 -0
- tooluniverse/biorxiv_tool.py +35 -16
- tooluniverse/build_optimizer.py +87 -0
- tooluniverse/cache/__init__.py +3 -0
- tooluniverse/cache/memory_cache.py +99 -0
- tooluniverse/cache/result_cache_manager.py +235 -0
- tooluniverse/cache/sqlite_backend.py +257 -0
- tooluniverse/cellosaurus_tool.py +1332 -0
- tooluniverse/clinvar_tool.py +90 -0
- tooluniverse/compose_scripts/enhanced_multi_agent_literature_search.py +310 -0
- tooluniverse/compose_scripts/multi_agent_literature_search.py +794 -0
- tooluniverse/compose_scripts/tool_graph_generation.py +68 -35
- tooluniverse/compose_scripts/tool_metadata_generator.py +205 -105
- tooluniverse/compose_tool.py +93 -8
- tooluniverse/core_tool.py +46 -44
- tooluniverse/crossref_tool.py +89 -4
- tooluniverse/custom_tool.py +28 -0
- tooluniverse/data/agentic_tools.json +1271 -1179
- tooluniverse/data/alphafold_tools.json +356 -105
- tooluniverse/data/arxiv_tools.json +85 -81
- tooluniverse/data/biorxiv_tools.json +69 -64
- tooluniverse/data/cellosaurus_tools.json +260 -0
- tooluniverse/data/chembl_tools.json +27 -12
- tooluniverse/data/clinicaltrials_gov_tools.json +377 -302
- tooluniverse/data/compose_tools.json +123 -16
- tooluniverse/data/core_tools.json +104 -99
- tooluniverse/data/crossref_tools.json +131 -63
- tooluniverse/data/dailymed_tools.json +17 -3
- tooluniverse/data/dataset_tools.json +1031 -588
- tooluniverse/data/dblp_tools.json +135 -64
- tooluniverse/data/disease_target_score_tools.json +20 -10
- tooluniverse/data/doaj_tools.json +131 -87
- tooluniverse/data/drug_discovery_agents.json +292 -0
- tooluniverse/data/embedding_tools.json +362 -299
- tooluniverse/data/enrichr_tools.json +34 -27
- tooluniverse/data/europe_pmc_tools.json +107 -16
- tooluniverse/data/fatcat_tools.json +71 -66
- tooluniverse/data/fda_drug_adverse_event_tools.json +1061 -445
- tooluniverse/data/fda_drug_labeling_tools.json +6858 -6901
- tooluniverse/data/finder_tools.json +32 -37
- tooluniverse/data/gene_ontology_tools.json +19 -7
- tooluniverse/data/genomics_tools.json +174 -0
- tooluniverse/data/geo_tools.json +86 -0
- tooluniverse/data/gwas_tools.json +1720 -959
- tooluniverse/data/hal_tools.json +69 -64
- tooluniverse/data/hpa_tools.json +53 -14
- tooluniverse/data/humanbase_tools.json +51 -43
- tooluniverse/data/idmap_tools.json +76 -70
- tooluniverse/data/literature_search_tools.json +306 -0
- tooluniverse/data/markitdown_tools.json +51 -0
- tooluniverse/data/mcp_client_tools_example.json +122 -107
- tooluniverse/data/medlineplus_tools.json +50 -10
- tooluniverse/data/medrxiv_tools.json +69 -64
- tooluniverse/data/molecule_2d_tools.json +134 -0
- tooluniverse/data/molecule_3d_tools.json +164 -0
- tooluniverse/data/monarch_tools.json +112 -110
- tooluniverse/data/odphp_tools.json +389 -119
- tooluniverse/data/openaire_tools.json +89 -79
- tooluniverse/data/openalex_tools.json +96 -31
- tooluniverse/data/opentarget_tools.json +1457 -1372
- tooluniverse/data/osf_preprints_tools.json +77 -73
- tooluniverse/data/packages/bioinformatics_core_tools.json +40 -10
- tooluniverse/data/packages/cheminformatics_tools.json +20 -5
- tooluniverse/data/packages/genomics_tools.json +36 -9
- tooluniverse/data/packages/machine_learning_tools.json +36 -9
- tooluniverse/data/packages/scientific_computing_tools.json +20 -5
- tooluniverse/data/packages/single_cell_tools.json +20 -5
- tooluniverse/data/packages/structural_biology_tools.json +16 -4
- tooluniverse/data/packages/visualization_tools.json +20 -5
- tooluniverse/data/pmc_tools.json +108 -103
- tooluniverse/data/ppi_tools.json +139 -0
- tooluniverse/data/protein_structure_3d_tools.json +138 -0
- tooluniverse/data/pubchem_tools.json +37 -12
- tooluniverse/data/pubmed_tools.json +124 -58
- tooluniverse/data/pubtator_tools.json +68 -60
- tooluniverse/data/rcsb_pdb_tools.json +1532 -1221
- tooluniverse/data/semantic_scholar_tools.json +54 -22
- tooluniverse/data/special_tools.json +8 -6
- tooluniverse/data/tool_composition_tools.json +112 -82
- tooluniverse/data/unified_guideline_tools.json +909 -0
- tooluniverse/data/url_fetch_tools.json +102 -82
- tooluniverse/data/uspto_tools.json +49 -30
- tooluniverse/data/wikidata_sparql_tools.json +42 -39
- tooluniverse/data/xml_tools.json +3274 -3113
- tooluniverse/data/zenodo_tools.json +83 -76
- tooluniverse/dblp_tool.py +76 -6
- tooluniverse/dbsnp_tool.py +71 -0
- tooluniverse/default_config.py +19 -0
- tooluniverse/doaj_tool.py +76 -17
- tooluniverse/doctor.py +48 -0
- tooluniverse/ensembl_tool.py +61 -0
- tooluniverse/europe_pmc_tool.py +132 -17
- tooluniverse/exceptions.py +170 -0
- tooluniverse/execute_function.py +930 -387
- tooluniverse/fatcat_tool.py +0 -1
- tooluniverse/generate_tools.py +481 -0
- tooluniverse/genomics_gene_search_tool.py +56 -0
- tooluniverse/geo_tool.py +116 -0
- tooluniverse/gnomad_tool.py +63 -0
- tooluniverse/hal_tool.py +1 -1
- tooluniverse/llm_clients.py +101 -124
- tooluniverse/markitdown_tool.py +159 -0
- tooluniverse/mcp_client_tool.py +10 -5
- tooluniverse/mcp_tool_registry.py +4 -1
- tooluniverse/medrxiv_tool.py +32 -13
- tooluniverse/memory_manager.py +166 -0
- tooluniverse/molecule_2d_tool.py +274 -0
- tooluniverse/molecule_3d_tool.py +441 -0
- tooluniverse/odphp_tool.py +49 -14
- tooluniverse/openaire_tool.py +5 -20
- tooluniverse/openalex_tool.py +34 -0
- tooluniverse/osf_preprints_tool.py +1 -1
- tooluniverse/pmc_tool.py +54 -56
- tooluniverse/protein_structure_3d_tool.py +295 -0
- tooluniverse/pubmed_tool.py +69 -6
- tooluniverse/remote/boltz/boltz_mcp_server.py +3 -1
- tooluniverse/remote/uspto_downloader/uspto_downloader_mcp_server.py +3 -1
- tooluniverse/semantic_scholar_tool.py +40 -10
- tooluniverse/smcp.py +149 -213
- tooluniverse/smcp_server.py +97 -55
- tooluniverse/string_tool.py +112 -0
- tooluniverse/tool_registry.py +35 -3
- tooluniverse/tools/ADMETAI_predict_BBB_penetrance.py +46 -0
- tooluniverse/tools/ADMETAI_predict_CYP_interactions.py +46 -0
- tooluniverse/tools/ADMETAI_predict_bioavailability.py +46 -0
- tooluniverse/tools/ADMETAI_predict_clearance_distribution.py +49 -0
- tooluniverse/tools/ADMETAI_predict_nuclear_receptor_activity.py +49 -0
- tooluniverse/tools/ADMETAI_predict_physicochemical_properties.py +49 -0
- tooluniverse/tools/ADMETAI_predict_solubility_lipophilicity_hydration.py +49 -0
- tooluniverse/tools/ADMETAI_predict_stress_response.py +46 -0
- tooluniverse/tools/ADMETAI_predict_toxicity.py +46 -0
- tooluniverse/tools/ADMETAnalyzerAgent.py +59 -0
- tooluniverse/tools/AdvancedCodeQualityAnalyzer.py +63 -0
- tooluniverse/tools/AdverseEventICDMapper.py +46 -0
- tooluniverse/tools/AdverseEventPredictionQuestionGenerator.py +52 -0
- tooluniverse/tools/AdverseEventPredictionQuestionGeneratorWithContext.py +59 -0
- tooluniverse/tools/ArXiv_search_papers.py +63 -0
- tooluniverse/tools/ArgumentDescriptionOptimizer.py +55 -0
- tooluniverse/tools/BioRxiv_search_preprints.py +52 -0
- tooluniverse/tools/BiomarkerDiscoveryWorkflow.py +55 -0
- tooluniverse/tools/CMA_Guidelines_Search.py +52 -0
- tooluniverse/tools/CORE_search_papers.py +67 -0
- tooluniverse/tools/CallAgent.py +46 -0
- tooluniverse/tools/ChEMBL_search_similar_molecules.py +59 -0
- tooluniverse/tools/ClinVar_search_variants.py +52 -0
- tooluniverse/tools/ClinicalTrialDesignAgent.py +63 -0
- tooluniverse/tools/CodeOptimizer.py +55 -0
- tooluniverse/tools/CodeQualityAnalyzer.py +71 -0
- tooluniverse/tools/CompoundDiscoveryAgent.py +59 -0
- tooluniverse/tools/ComprehensiveDrugDiscoveryPipeline.py +49 -0
- tooluniverse/tools/Crossref_search_works.py +55 -0
- tooluniverse/tools/DBLP_search_publications.py +52 -0
- tooluniverse/tools/DOAJ_search_articles.py +55 -0
- tooluniverse/tools/DailyMed_get_spl_by_setid.py +52 -0
- tooluniverse/tools/DailyMed_search_spls.py +79 -0
- tooluniverse/tools/DataAnalysisValidityReviewer.py +49 -0
- tooluniverse/tools/DescriptionAnalyzer.py +55 -0
- tooluniverse/tools/DescriptionQualityEvaluator.py +59 -0
- tooluniverse/tools/DiseaseAnalyzerAgent.py +52 -0
- tooluniverse/tools/DomainExpertValidator.py +63 -0
- tooluniverse/tools/DrugInteractionAnalyzerAgent.py +52 -0
- tooluniverse/tools/DrugOptimizationAgent.py +63 -0
- tooluniverse/tools/DrugSafetyAnalyzer.py +59 -0
- tooluniverse/tools/Ensembl_lookup_gene_by_symbol.py +52 -0
- tooluniverse/tools/EthicalComplianceReviewer.py +49 -0
- tooluniverse/tools/EuropePMC_Guidelines_Search.py +52 -0
- tooluniverse/tools/EuropePMC_search_articles.py +52 -0
- tooluniverse/tools/ExperimentalDesignScorer.py +55 -0
- tooluniverse/tools/FAERS_count_additive_administration_routes.py +52 -0
- tooluniverse/tools/FAERS_count_additive_adverse_reactions.py +71 -0
- tooluniverse/tools/FAERS_count_additive_event_reports_by_country.py +63 -0
- tooluniverse/tools/FAERS_count_additive_reaction_outcomes.py +63 -0
- tooluniverse/tools/FAERS_count_additive_reports_by_reporter_country.py +63 -0
- tooluniverse/tools/FAERS_count_additive_seriousness_classification.py +63 -0
- tooluniverse/tools/FAERS_count_country_by_drug_event.py +63 -0
- tooluniverse/tools/FAERS_count_death_related_by_drug.py +49 -0
- tooluniverse/tools/FAERS_count_drug_routes_by_event.py +52 -0
- tooluniverse/tools/FAERS_count_drugs_by_drug_event.py +63 -0
- tooluniverse/tools/FAERS_count_outcomes_by_drug_event.py +63 -0
- tooluniverse/tools/FAERS_count_patient_age_distribution.py +49 -0
- tooluniverse/tools/FAERS_count_reactions_by_drug_event.py +71 -0
- tooluniverse/tools/FAERS_count_reportercountry_by_drug_event.py +63 -0
- tooluniverse/tools/FAERS_count_seriousness_by_drug_event.py +63 -0
- tooluniverse/tools/FDA_get_abuse_dependence_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_abuse_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_accessories_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_active_ingredient_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_adverse_reactions_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_alarms_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_animal_pharmacology_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_assembly_installation_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_boxed_warning_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_brand_name_generic_name.py +52 -0
- tooluniverse/tools/FDA_get_calibration_instructions_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_carcinogenic_mutagenic_fertility_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_child_safety_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_clinical_pharmacology_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_clinical_studies_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_contact_for_questions_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_contraindications_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_controlled_substance_DEA_schedule_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_dear_health_care_provider_letter_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_dependence_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_disposal_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_do_not_use_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_document_id_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_dosage_and_storage_information_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_dosage_forms_and_strengths_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_drug_generic_name.py +46 -0
- tooluniverse/tools/FDA_get_drug_interactions_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_SPL_ID.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_adverse_reaction.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_calibration_instructions.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_dependence_info.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_document_id.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_dosage_info.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_environmental_warning.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_inactive_ingredient.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_info_on_conditions_for_doctor_consultation.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_labor_and_delivery_info.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_microbiology.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_other_safety_info.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_pharmacodynamics.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_pharmacogenomics.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_precautions.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_pregnancy_or_breastfeeding_info.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_principal_display_panel.py +59 -0
- tooluniverse/tools/FDA_get_drug_name_by_reference.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_set_id.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_stop_use_info.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_storage_and_handling_info.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_by_warnings.py +55 -0
- tooluniverse/tools/FDA_get_drug_name_from_patient_package_insert.py +59 -0
- tooluniverse/tools/FDA_get_drug_names_by_abuse_dependence_info.py +55 -0
- tooluniverse/tools/FDA_get_drug_names_by_abuse_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_accessories.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_active_ingredient.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_alarm.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_animal_pharmacology_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_application_number_NDC_number.py +59 -0
- tooluniverse/tools/FDA_get_drug_names_by_assembly_installation_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_boxed_warning.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_child_safety_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_clinical_pharmacology.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_clinical_studies.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_consulting_doctor_pharmacist_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_contraindications.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_controlled_substance_DEA_schedule.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_dear_health_care_provider_letter_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_disposal_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_dosage_forms_and_strengths_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_drug_interactions.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_effective_time.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_food_safety_warnings.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_general_precautions.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_geriatric_use.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_health_claim.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_indication.py +55 -0
- tooluniverse/tools/FDA_get_drug_names_by_info_for_nursing_mothers.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_information_for_owners_or_caregivers.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_ingredient.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_instructions_for_use.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_lab_test_interference.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_lab_tests.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_mechanism_of_action.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_medication_guide.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_nonclinical_toxicology_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_nonteratogenic_effects.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_overdosage_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_pediatric_use.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_pharmacokinetics.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_population_use.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_pregnancy_effects_info.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_residue_warning.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_risk.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_route.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_safe_handling_warning.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_safety_summary.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_spl_indexing_data_elements.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_teratogenic_effects.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_user_safety_warning.py +63 -0
- tooluniverse/tools/FDA_get_drug_names_by_warnings_and_cautions.py +63 -0
- tooluniverse/tools/FDA_get_drugs_by_carcinogenic_mutagenic_fertility.py +63 -0
- tooluniverse/tools/FDA_get_effective_time_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_environmental_warning_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_general_precautions_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_geriatric_use_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_health_claims_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_inactive_ingredient_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_indications_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_info_for_nursing_mothers_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_info_for_patients_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_info_on_conditions_for_doctor_consultation_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_info_on_consulting_doctor_pharmacist_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_information_for_owners_or_caregivers_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_ingredients_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_instructions_for_use_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_lab_test_interference_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_lab_tests_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_labor_and_delivery_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_manufacturer_name_NDC_number_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_mechanism_of_action_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_medication_guide_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_microbiology_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_nonclinical_toxicology_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_nonteratogenic_effects_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_other_safety_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_overdosage_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_patient_package_insert_from_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_pediatric_use_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_pharmacodynamics_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_pharmacogenomics_info_by_drug_name.py +55 -0
- tooluniverse/tools/FDA_get_pharmacokinetics_by_drug_name.py +55 -0
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"description": "Count the number of adverse reactions reported for a given drug, filtered by patient details, event seriousness, and reaction outcomes. Data source: FDA Adverse Event Reporting System (FAERS).",
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+
"type": "FDADrugAdverseEventTool",
|
|
92
|
+
"name": "FAERS_count_drugs_by_drug_event",
|
|
93
|
+
"description": "Count the number of different drugs involved in FDA adverse event reports, filtered by patient details, country, and seriousness. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
94
|
+
"parameter": {
|
|
95
|
+
"type": "object",
|
|
96
|
+
"properties": {
|
|
97
|
+
"patientsex": {
|
|
98
|
+
"type": "string",
|
|
99
|
+
"enum": [
|
|
100
|
+
"Male",
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|
101
|
+
"Female"
|
|
102
|
+
],
|
|
103
|
+
"description": "Patient sex, leave it blank if you don't want to apply a filter."
|
|
104
|
+
},
|
|
105
|
+
"patientagegroup": {
|
|
106
|
+
"type": "string",
|
|
107
|
+
"enum": [
|
|
108
|
+
"Neonate",
|
|
109
|
+
"Infant",
|
|
110
|
+
"Child",
|
|
111
|
+
"Adolescent",
|
|
112
|
+
"Adult",
|
|
113
|
+
"Elderly"
|
|
114
|
+
],
|
|
115
|
+
"description": "Patient age group."
|
|
116
|
+
},
|
|
117
|
+
"occurcountry": {
|
|
118
|
+
"type": "string",
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|
119
|
+
"pattern": "^[A-Z]{2}$",
|
|
120
|
+
"description": "Country where event occurred."
|
|
121
|
+
},
|
|
122
|
+
"serious": {
|
|
123
|
+
"type": "string",
|
|
124
|
+
"enum": [
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125
|
+
"Yes",
|
|
126
|
+
"No"
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|
127
|
+
],
|
|
128
|
+
"description": "Whether the event was serious."
|
|
129
|
+
}
|
|
130
|
+
},
|
|
131
|
+
"required": [
|
|
132
|
+
"patientsex",
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133
|
+
"patientagegroup",
|
|
134
|
+
"occurcountry",
|
|
135
|
+
"serious"
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136
|
+
]
|
|
53
137
|
},
|
|
54
|
-
{
|
|
55
|
-
"
|
|
56
|
-
|
|
57
|
-
|
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58
|
-
|
|
59
|
-
"
|
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60
|
-
|
|
61
|
-
|
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62
|
-
|
|
63
|
-
"
|
|
64
|
-
|
|
65
|
-
|
|
66
|
-
|
|
138
|
+
"fields": {
|
|
139
|
+
"search_fields": {
|
|
140
|
+
"patientsex": [
|
|
141
|
+
"patient.patientsex"
|
|
142
|
+
],
|
|
143
|
+
"patientagegroup": [
|
|
144
|
+
"patient.patientagegroup"
|
|
145
|
+
],
|
|
146
|
+
"occurcountry": [
|
|
147
|
+
"occurcountry"
|
|
148
|
+
],
|
|
149
|
+
"serious": [
|
|
150
|
+
"serious"
|
|
151
|
+
]
|
|
67
152
|
},
|
|
68
|
-
"
|
|
69
|
-
"
|
|
70
|
-
|
|
71
|
-
|
|
72
|
-
|
|
73
|
-
|
|
74
|
-
|
|
75
|
-
|
|
76
|
-
|
|
153
|
+
"return_fields": [
|
|
154
|
+
"patient.drug.medicinalproduct.exact"
|
|
155
|
+
]
|
|
156
|
+
}
|
|
157
|
+
},
|
|
158
|
+
{
|
|
159
|
+
"type": "FDADrugAdverseEventTool",
|
|
160
|
+
"name": "FAERS_count_country_by_drug_event",
|
|
161
|
+
"description": "Count the number of adverse event reports per country of occurrence, filtered by drug, patient demographics, and seriousness. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
162
|
+
"parameter": {
|
|
163
|
+
"type": "object",
|
|
164
|
+
"properties": {
|
|
165
|
+
"medicinalproduct": {
|
|
166
|
+
"type": "string",
|
|
167
|
+
"description": "Drug name."
|
|
168
|
+
},
|
|
169
|
+
"patientsex": {
|
|
170
|
+
"type": "string",
|
|
171
|
+
"enum": [
|
|
172
|
+
"Male",
|
|
173
|
+
"Female"
|
|
174
|
+
],
|
|
175
|
+
"description": "Patient sex, leave it blank if you don't want to apply a filter."
|
|
176
|
+
},
|
|
177
|
+
"patientagegroup": {
|
|
178
|
+
"type": "string",
|
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179
|
+
"enum": [
|
|
180
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+
"Neonate",
|
|
181
|
+
"Infant",
|
|
182
|
+
"Child",
|
|
183
|
+
"Adolescent",
|
|
184
|
+
"Adult",
|
|
185
|
+
"Elderly"
|
|
186
|
+
],
|
|
187
|
+
"description": "Patient age group."
|
|
188
|
+
},
|
|
189
|
+
"serious": {
|
|
190
|
+
"type": "string",
|
|
191
|
+
"enum": [
|
|
192
|
+
"Yes",
|
|
193
|
+
"No"
|
|
194
|
+
],
|
|
195
|
+
"description": "Whether the event was serious."
|
|
196
|
+
}
|
|
197
|
+
},
|
|
198
|
+
"required": [
|
|
199
|
+
"medicinalproduct",
|
|
200
|
+
"patientsex",
|
|
201
|
+
"patientagegroup",
|
|
202
|
+
"serious"
|
|
203
|
+
]
|
|
77
204
|
},
|
|
78
|
-
{
|
|
79
|
-
"
|
|
80
|
-
|
|
81
|
-
|
|
82
|
-
|
|
83
|
-
"
|
|
84
|
-
|
|
85
|
-
|
|
86
|
-
|
|
87
|
-
"patientagegroup"
|
|
88
|
-
|
|
89
|
-
|
|
90
|
-
|
|
205
|
+
"fields": {
|
|
206
|
+
"search_fields": {
|
|
207
|
+
"medicinalproduct": [
|
|
208
|
+
"patient.drug.medicinalproduct"
|
|
209
|
+
],
|
|
210
|
+
"patientsex": [
|
|
211
|
+
"patient.patientsex"
|
|
212
|
+
],
|
|
213
|
+
"patientagegroup": [
|
|
214
|
+
"patient.patientagegroup"
|
|
215
|
+
],
|
|
216
|
+
"serious": [
|
|
217
|
+
"serious"
|
|
218
|
+
]
|
|
91
219
|
},
|
|
92
|
-
"
|
|
93
|
-
"
|
|
94
|
-
|
|
95
|
-
|
|
96
|
-
|
|
97
|
-
|
|
98
|
-
|
|
99
|
-
|
|
100
|
-
|
|
220
|
+
"return_fields": [
|
|
221
|
+
"occurcountry.exact"
|
|
222
|
+
]
|
|
223
|
+
}
|
|
224
|
+
},
|
|
225
|
+
{
|
|
226
|
+
"type": "FDADrugAdverseEventTool",
|
|
227
|
+
"name": "FAERS_count_reportercountry_by_drug_event",
|
|
228
|
+
"description": "Count the number of FDA adverse event reports grouped by the country of the primary reporter. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
229
|
+
"parameter": {
|
|
230
|
+
"type": "object",
|
|
231
|
+
"properties": {
|
|
232
|
+
"medicinalproduct": {
|
|
233
|
+
"type": "string",
|
|
234
|
+
"description": "Drug name."
|
|
235
|
+
},
|
|
236
|
+
"patientsex": {
|
|
237
|
+
"type": "string",
|
|
238
|
+
"enum": [
|
|
239
|
+
"Male",
|
|
240
|
+
"Female"
|
|
241
|
+
],
|
|
242
|
+
"description": "Patient sex, leave it blank if you don't want to apply a filter."
|
|
243
|
+
},
|
|
244
|
+
"patientagegroup": {
|
|
245
|
+
"type": "string",
|
|
246
|
+
"enum": [
|
|
247
|
+
"Neonate",
|
|
248
|
+
"Infant",
|
|
249
|
+
"Child",
|
|
250
|
+
"Adolescent",
|
|
251
|
+
"Adult",
|
|
252
|
+
"Elderly"
|
|
253
|
+
],
|
|
254
|
+
"description": "Patient age group."
|
|
255
|
+
},
|
|
256
|
+
"serious": {
|
|
257
|
+
"type": "string",
|
|
258
|
+
"enum": [
|
|
259
|
+
"Yes",
|
|
260
|
+
"No"
|
|
261
|
+
],
|
|
262
|
+
"description": "Whether the event was serious."
|
|
263
|
+
}
|
|
264
|
+
},
|
|
265
|
+
"required": [
|
|
266
|
+
"medicinalproduct",
|
|
267
|
+
"patientsex",
|
|
268
|
+
"patientagegroup",
|
|
269
|
+
"serious"
|
|
270
|
+
]
|
|
101
271
|
},
|
|
102
|
-
{
|
|
103
|
-
"
|
|
104
|
-
|
|
105
|
-
|
|
106
|
-
|
|
107
|
-
"
|
|
108
|
-
|
|
109
|
-
|
|
110
|
-
|
|
111
|
-
"patientagegroup"
|
|
112
|
-
|
|
113
|
-
|
|
114
|
-
|
|
272
|
+
"fields": {
|
|
273
|
+
"search_fields": {
|
|
274
|
+
"medicinalproduct": [
|
|
275
|
+
"patient.drug.medicinalproduct"
|
|
276
|
+
],
|
|
277
|
+
"patientsex": [
|
|
278
|
+
"patient.patientsex"
|
|
279
|
+
],
|
|
280
|
+
"patientagegroup": [
|
|
281
|
+
"patient.patientagegroup"
|
|
282
|
+
],
|
|
283
|
+
"serious": [
|
|
284
|
+
"serious"
|
|
285
|
+
]
|
|
115
286
|
},
|
|
116
|
-
"
|
|
117
|
-
"
|
|
118
|
-
|
|
119
|
-
|
|
120
|
-
|
|
121
|
-
|
|
122
|
-
|
|
123
|
-
|
|
124
|
-
|
|
125
|
-
|
|
126
|
-
|
|
127
|
-
|
|
128
|
-
|
|
287
|
+
"return_fields": [
|
|
288
|
+
"primarysource.reportercountry.exact"
|
|
289
|
+
]
|
|
290
|
+
}
|
|
291
|
+
},
|
|
292
|
+
{
|
|
293
|
+
"type": "FDADrugAdverseEventTool",
|
|
294
|
+
"name": "FAERS_count_seriousness_by_drug_event",
|
|
295
|
+
"description": "Count the number of adverse event reports classified as serious or non-serious, filtered by drug and patient demographics. In results, term Serious means: 'The adverse event resulted in death, a life threatening condition, hospitalization, disability, congenital anomaly, or other serious condition', term Non-serious means 'The adverse event did not result in any of the above' Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
296
|
+
"parameter": {
|
|
297
|
+
"type": "object",
|
|
298
|
+
"properties": {
|
|
299
|
+
"medicinalproduct": {
|
|
300
|
+
"type": "string",
|
|
301
|
+
"description": "Drug name."
|
|
302
|
+
},
|
|
303
|
+
"patientsex": {
|
|
304
|
+
"type": "string",
|
|
305
|
+
"enum": [
|
|
306
|
+
"Male",
|
|
307
|
+
"Female"
|
|
308
|
+
],
|
|
309
|
+
"description": "Patient sex, leave it blank if you don't want to apply a filter."
|
|
310
|
+
},
|
|
311
|
+
"patientagegroup": {
|
|
312
|
+
"type": "string",
|
|
313
|
+
"enum": [
|
|
314
|
+
"Neonate",
|
|
315
|
+
"Infant",
|
|
316
|
+
"Child",
|
|
317
|
+
"Adolescent",
|
|
318
|
+
"Adult",
|
|
319
|
+
"Elderly"
|
|
320
|
+
],
|
|
321
|
+
"description": "Patient age group."
|
|
322
|
+
},
|
|
323
|
+
"occurcountry": {
|
|
324
|
+
"type": "string",
|
|
325
|
+
"pattern": "^[A-Z]{2}$",
|
|
326
|
+
"description": "Country where event occurred."
|
|
129
327
|
}
|
|
130
|
-
}
|
|
328
|
+
},
|
|
329
|
+
"required": [
|
|
330
|
+
"medicinalproduct",
|
|
331
|
+
"patientsex",
|
|
332
|
+
"patientagegroup",
|
|
333
|
+
"occurcountry"
|
|
334
|
+
]
|
|
131
335
|
},
|
|
132
|
-
{
|
|
133
|
-
"
|
|
134
|
-
|
|
135
|
-
|
|
136
|
-
|
|
137
|
-
"
|
|
138
|
-
|
|
139
|
-
|
|
140
|
-
|
|
141
|
-
"patientagegroup"
|
|
142
|
-
|
|
143
|
-
|
|
144
|
-
|
|
336
|
+
"fields": {
|
|
337
|
+
"search_fields": {
|
|
338
|
+
"medicinalproduct": [
|
|
339
|
+
"patient.drug.medicinalproduct"
|
|
340
|
+
],
|
|
341
|
+
"patientsex": [
|
|
342
|
+
"patient.patientsex"
|
|
343
|
+
],
|
|
344
|
+
"patientagegroup": [
|
|
345
|
+
"patient.patientagegroup"
|
|
346
|
+
],
|
|
347
|
+
"occurcountry": [
|
|
348
|
+
"occurcountry"
|
|
349
|
+
]
|
|
145
350
|
},
|
|
146
|
-
"
|
|
147
|
-
"
|
|
148
|
-
|
|
149
|
-
|
|
150
|
-
|
|
151
|
-
"
|
|
152
|
-
|
|
153
|
-
"return_fields": ["patient.reaction.reactionoutcome"],
|
|
154
|
-
"return_fields_mapping": {
|
|
155
|
-
"patient.reaction.reactionoutcome": {
|
|
156
|
-
"1": "Recovered/resolved",
|
|
157
|
-
"2": "Recovering/resolving",
|
|
158
|
-
"3": "Not recovered/not resolved",
|
|
159
|
-
"4": "Recovered/resolved with sequelae (consequent health issues)",
|
|
160
|
-
"5": "Fatal",
|
|
161
|
-
"6": "Unknown"
|
|
162
|
-
}
|
|
351
|
+
"return_fields": [
|
|
352
|
+
"serious"
|
|
353
|
+
],
|
|
354
|
+
"return_fields_mapping": {
|
|
355
|
+
"serious": {
|
|
356
|
+
"1": "Serious",
|
|
357
|
+
"2": "Non-serious"
|
|
163
358
|
}
|
|
164
359
|
}
|
|
360
|
+
}
|
|
361
|
+
},
|
|
362
|
+
{
|
|
363
|
+
"type": "FDADrugAdverseEventTool",
|
|
364
|
+
"name": "FAERS_count_outcomes_by_drug_event",
|
|
365
|
+
"description": "Count the outcome of adverse reactions (recovered, recovering, fatal, unresolved) filtered by drug, seriousness, and demographics. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
366
|
+
"parameter": {
|
|
367
|
+
"type": "object",
|
|
368
|
+
"properties": {
|
|
369
|
+
"medicinalproduct": {
|
|
370
|
+
"type": "string",
|
|
371
|
+
"description": "Drug name."
|
|
372
|
+
},
|
|
373
|
+
"patientsex": {
|
|
374
|
+
"type": "string",
|
|
375
|
+
"enum": [
|
|
376
|
+
"Male",
|
|
377
|
+
"Female"
|
|
378
|
+
]
|
|
379
|
+
},
|
|
380
|
+
"patientagegroup": {
|
|
381
|
+
"type": "string",
|
|
382
|
+
"enum": [
|
|
383
|
+
"Neonate",
|
|
384
|
+
"Infant",
|
|
385
|
+
"Child",
|
|
386
|
+
"Adolescent",
|
|
387
|
+
"Adult",
|
|
388
|
+
"Elderly"
|
|
389
|
+
]
|
|
390
|
+
},
|
|
391
|
+
"occurcountry": {
|
|
392
|
+
"type": "string",
|
|
393
|
+
"pattern": "^[A-Z]{2}$"
|
|
394
|
+
}
|
|
395
|
+
},
|
|
396
|
+
"required": [
|
|
397
|
+
"medicinalproduct",
|
|
398
|
+
"patientsex",
|
|
399
|
+
"patientagegroup",
|
|
400
|
+
"occurcountry"
|
|
401
|
+
]
|
|
165
402
|
},
|
|
166
|
-
{
|
|
167
|
-
"
|
|
168
|
-
|
|
169
|
-
|
|
170
|
-
|
|
171
|
-
"
|
|
172
|
-
|
|
173
|
-
|
|
174
|
-
|
|
175
|
-
|
|
176
|
-
|
|
403
|
+
"fields": {
|
|
404
|
+
"search_fields": {
|
|
405
|
+
"medicinalproduct": [
|
|
406
|
+
"patient.drug.medicinalproduct"
|
|
407
|
+
],
|
|
408
|
+
"patientsex": [
|
|
409
|
+
"patient.patientsex"
|
|
410
|
+
],
|
|
411
|
+
"patientagegroup": [
|
|
412
|
+
"patient.patientagegroup"
|
|
413
|
+
],
|
|
414
|
+
"occurcountry": [
|
|
415
|
+
"occurcountry"
|
|
416
|
+
]
|
|
177
417
|
},
|
|
178
|
-
"
|
|
179
|
-
"
|
|
180
|
-
|
|
181
|
-
|
|
182
|
-
|
|
183
|
-
|
|
184
|
-
|
|
185
|
-
"
|
|
186
|
-
|
|
187
|
-
|
|
188
|
-
|
|
189
|
-
"004": "Dental",
|
|
190
|
-
"005": "Endocervical",
|
|
191
|
-
"006": "Endosinusial",
|
|
192
|
-
"007": "Endotracheal",
|
|
193
|
-
"008": "Epidural",
|
|
194
|
-
"009": "Extra-amniotic",
|
|
195
|
-
"010": "Hemodialysis",
|
|
196
|
-
"011": "Intra corpus cavernosum",
|
|
197
|
-
"012": "Intra-amniotic",
|
|
198
|
-
"013": "Intra-arterial",
|
|
199
|
-
"014": "Intra-articular",
|
|
200
|
-
"015": "Intra-uterine",
|
|
201
|
-
"016": "Intracardiac",
|
|
202
|
-
"017": "Intracavernous",
|
|
203
|
-
"018": "Intracerebral",
|
|
204
|
-
"019": "Intracervical",
|
|
205
|
-
"020": "Intracisternal",
|
|
206
|
-
"021": "Intracorneal",
|
|
207
|
-
"022": "Intracoronary",
|
|
208
|
-
"023": "Intradermal",
|
|
209
|
-
"024": "Intradiscal (intraspinal)",
|
|
210
|
-
"025": "Intrahepatic",
|
|
211
|
-
"026": "Intralesional",
|
|
212
|
-
"027": "Intralymphatic",
|
|
213
|
-
"028": "Intramedullar (bone marrow)",
|
|
214
|
-
"029": "Intrameningeal",
|
|
215
|
-
"030": "Intramuscular",
|
|
216
|
-
"031": "Intraocular",
|
|
217
|
-
"032": "Intrapericardial",
|
|
218
|
-
"033": "Intraperitoneal",
|
|
219
|
-
"034": "Intrapleural",
|
|
220
|
-
"035": "Intrasynovial",
|
|
221
|
-
"036": "Intratumor",
|
|
222
|
-
"037": "Intrathecal",
|
|
223
|
-
"038": "Intrathoracic",
|
|
224
|
-
"039": "Intratracheal",
|
|
225
|
-
"040": "Intravenous bolus",
|
|
226
|
-
"041": "Intravenous drip",
|
|
227
|
-
"042": "Intravenous (not otherwise specified)",
|
|
228
|
-
"043": "Intravesical",
|
|
229
|
-
"044": "Iontophoresis",
|
|
230
|
-
"045": "Nasal",
|
|
231
|
-
"046": "Occlusive dressing technique",
|
|
232
|
-
"047": "Ophthalmic",
|
|
233
|
-
"048": "Oral",
|
|
234
|
-
"049": "Oropharingeal",
|
|
235
|
-
"050": "Other",
|
|
236
|
-
"051": "Parenteral",
|
|
237
|
-
"052": "Periarticular",
|
|
238
|
-
"053": "Perineural",
|
|
239
|
-
"054": "Rectal",
|
|
240
|
-
"055": "Respiratory (inhalation)",
|
|
241
|
-
"056": "Retrobulbar",
|
|
242
|
-
"057": "Sunconjunctival",
|
|
243
|
-
"058": "Subcutaneous",
|
|
244
|
-
"059": "Subdermal",
|
|
245
|
-
"060": "Sublingual",
|
|
246
|
-
"061": "Topical",
|
|
247
|
-
"062": "Transdermal",
|
|
248
|
-
"063": "Transmammary",
|
|
249
|
-
"064": "Transplacental",
|
|
250
|
-
"065": "Unknown",
|
|
251
|
-
"066": "Urethral",
|
|
252
|
-
"067": "Vaginal"
|
|
253
|
-
}
|
|
418
|
+
"return_fields": [
|
|
419
|
+
"patient.reaction.reactionoutcome"
|
|
420
|
+
],
|
|
421
|
+
"return_fields_mapping": {
|
|
422
|
+
"patient.reaction.reactionoutcome": {
|
|
423
|
+
"1": "Recovered/resolved",
|
|
424
|
+
"2": "Recovering/resolving",
|
|
425
|
+
"3": "Not recovered/not resolved",
|
|
426
|
+
"4": "Recovered/resolved with sequelae (consequent health issues)",
|
|
427
|
+
"5": "Fatal",
|
|
428
|
+
"6": "Unknown"
|
|
254
429
|
}
|
|
255
430
|
}
|
|
431
|
+
}
|
|
432
|
+
},
|
|
433
|
+
{
|
|
434
|
+
"type": "FDADrugAdverseEventTool",
|
|
435
|
+
"name": "FAERS_count_drug_routes_by_event",
|
|
436
|
+
"description": "Count the most common routes of administration for drugs involved in adverse event reports. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
437
|
+
"parameter": {
|
|
438
|
+
"type": "object",
|
|
439
|
+
"properties": {
|
|
440
|
+
"medicinalproduct": {
|
|
441
|
+
"type": "string",
|
|
442
|
+
"description": "Drug name."
|
|
443
|
+
},
|
|
444
|
+
"serious": {
|
|
445
|
+
"type": "string",
|
|
446
|
+
"enum": [
|
|
447
|
+
"Yes",
|
|
448
|
+
"No"
|
|
449
|
+
],
|
|
450
|
+
"description": "Seriousness of event."
|
|
451
|
+
}
|
|
452
|
+
},
|
|
453
|
+
"required": [
|
|
454
|
+
"medicinalproduct",
|
|
455
|
+
"serious"
|
|
456
|
+
]
|
|
256
457
|
},
|
|
257
|
-
{
|
|
258
|
-
"
|
|
259
|
-
|
|
260
|
-
|
|
261
|
-
|
|
262
|
-
"
|
|
263
|
-
|
|
264
|
-
|
|
265
|
-
},
|
|
266
|
-
"required": ["medicinalproduct"]
|
|
458
|
+
"fields": {
|
|
459
|
+
"search_fields": {
|
|
460
|
+
"medicinalproduct": [
|
|
461
|
+
"patient.drug.medicinalproduct"
|
|
462
|
+
],
|
|
463
|
+
"serious": [
|
|
464
|
+
"serious"
|
|
465
|
+
]
|
|
267
466
|
},
|
|
268
|
-
"
|
|
269
|
-
"
|
|
270
|
-
|
|
271
|
-
|
|
272
|
-
"
|
|
273
|
-
|
|
274
|
-
"
|
|
275
|
-
|
|
276
|
-
|
|
277
|
-
|
|
278
|
-
|
|
279
|
-
|
|
280
|
-
|
|
281
|
-
|
|
467
|
+
"return_fields": [
|
|
468
|
+
"patient.drug.drugadministrationroute.exact"
|
|
469
|
+
],
|
|
470
|
+
"return_fields_mapping": {
|
|
471
|
+
"patient.drug.drugadministrationroute.exact": {
|
|
472
|
+
"001": "Auricular (otic)",
|
|
473
|
+
"002": "Buccal",
|
|
474
|
+
"003": "Cutaneous",
|
|
475
|
+
"004": "Dental",
|
|
476
|
+
"005": "Endocervical",
|
|
477
|
+
"006": "Endosinusial",
|
|
478
|
+
"007": "Endotracheal",
|
|
479
|
+
"008": "Epidural",
|
|
480
|
+
"009": "Extra-amniotic",
|
|
481
|
+
"010": "Hemodialysis",
|
|
482
|
+
"011": "Intra corpus cavernosum",
|
|
483
|
+
"012": "Intra-amniotic",
|
|
484
|
+
"013": "Intra-arterial",
|
|
485
|
+
"014": "Intra-articular",
|
|
486
|
+
"015": "Intra-uterine",
|
|
487
|
+
"016": "Intracardiac",
|
|
488
|
+
"017": "Intracavernous",
|
|
489
|
+
"018": "Intracerebral",
|
|
490
|
+
"019": "Intracervical",
|
|
491
|
+
"020": "Intracisternal",
|
|
492
|
+
"021": "Intracorneal",
|
|
493
|
+
"022": "Intracoronary",
|
|
494
|
+
"023": "Intradermal",
|
|
495
|
+
"024": "Intradiscal (intraspinal)",
|
|
496
|
+
"025": "Intrahepatic",
|
|
497
|
+
"026": "Intralesional",
|
|
498
|
+
"027": "Intralymphatic",
|
|
499
|
+
"028": "Intramedullar (bone marrow)",
|
|
500
|
+
"029": "Intrameningeal",
|
|
501
|
+
"030": "Intramuscular",
|
|
502
|
+
"031": "Intraocular",
|
|
503
|
+
"032": "Intrapericardial",
|
|
504
|
+
"033": "Intraperitoneal",
|
|
505
|
+
"034": "Intrapleural",
|
|
506
|
+
"035": "Intrasynovial",
|
|
507
|
+
"036": "Intratumor",
|
|
508
|
+
"037": "Intrathecal",
|
|
509
|
+
"038": "Intrathoracic",
|
|
510
|
+
"039": "Intratracheal",
|
|
511
|
+
"040": "Intravenous bolus",
|
|
512
|
+
"041": "Intravenous drip",
|
|
513
|
+
"042": "Intravenous (not otherwise specified)",
|
|
514
|
+
"043": "Intravesical",
|
|
515
|
+
"044": "Iontophoresis",
|
|
516
|
+
"045": "Nasal",
|
|
517
|
+
"046": "Occlusive dressing technique",
|
|
518
|
+
"047": "Ophthalmic",
|
|
519
|
+
"048": "Oral",
|
|
520
|
+
"049": "Oropharingeal",
|
|
521
|
+
"050": "Other",
|
|
522
|
+
"051": "Parenteral",
|
|
523
|
+
"052": "Periarticular",
|
|
524
|
+
"053": "Perineural",
|
|
525
|
+
"054": "Rectal",
|
|
526
|
+
"055": "Respiratory (inhalation)",
|
|
527
|
+
"056": "Retrobulbar",
|
|
528
|
+
"057": "Sunconjunctival",
|
|
529
|
+
"058": "Subcutaneous",
|
|
530
|
+
"059": "Subdermal",
|
|
531
|
+
"060": "Sublingual",
|
|
532
|
+
"061": "Topical",
|
|
533
|
+
"062": "Transdermal",
|
|
534
|
+
"063": "Transmammary",
|
|
535
|
+
"064": "Transplacental",
|
|
536
|
+
"065": "Unknown",
|
|
537
|
+
"066": "Urethral",
|
|
538
|
+
"067": "Vaginal"
|
|
282
539
|
}
|
|
283
540
|
}
|
|
541
|
+
}
|
|
542
|
+
},
|
|
543
|
+
{
|
|
544
|
+
"type": "FDADrugAdverseEventTool",
|
|
545
|
+
"name": "FAERS_count_patient_age_distribution",
|
|
546
|
+
"description": "Analyze the age distribution of patients experiencing adverse events for a specific drug. The age groups are: Neonate (0-28 days), Infant (29 days - 23 months), Child (2-11 years), Adolescent (12-17 years), Adult (18-64 years), Elderly (65+ years). Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
547
|
+
"parameter": {
|
|
548
|
+
"type": "object",
|
|
549
|
+
"properties": {
|
|
550
|
+
"medicinalproduct": {
|
|
551
|
+
"type": "string",
|
|
552
|
+
"description": "Drug name."
|
|
553
|
+
}
|
|
554
|
+
},
|
|
555
|
+
"required": [
|
|
556
|
+
"medicinalproduct"
|
|
557
|
+
]
|
|
284
558
|
},
|
|
285
|
-
{
|
|
286
|
-
"
|
|
287
|
-
|
|
288
|
-
|
|
289
|
-
|
|
290
|
-
"type": "object",
|
|
291
|
-
"properties": {
|
|
292
|
-
"medicinalproduct": { "type": "string", "description": "Drug name." }
|
|
293
|
-
},
|
|
294
|
-
"required": ["medicinalproduct"]
|
|
559
|
+
"fields": {
|
|
560
|
+
"search_fields": {
|
|
561
|
+
"medicinalproduct": [
|
|
562
|
+
"patient.drug.medicinalproduct"
|
|
563
|
+
]
|
|
295
564
|
},
|
|
296
|
-
"
|
|
297
|
-
"
|
|
298
|
-
|
|
299
|
-
|
|
300
|
-
|
|
301
|
-
|
|
302
|
-
|
|
303
|
-
"
|
|
304
|
-
|
|
305
|
-
|
|
306
|
-
|
|
565
|
+
"return_fields": [
|
|
566
|
+
"patient.patientagegroup"
|
|
567
|
+
],
|
|
568
|
+
"return_fields_mapping": {
|
|
569
|
+
"patient.patientagegroup": {
|
|
570
|
+
"1": "Neonate",
|
|
571
|
+
"2": "Infant",
|
|
572
|
+
"3": "Child",
|
|
573
|
+
"4": "Adolescent",
|
|
574
|
+
"5": "Adult",
|
|
575
|
+
"6": "Elderly"
|
|
307
576
|
}
|
|
308
577
|
}
|
|
578
|
+
}
|
|
579
|
+
},
|
|
580
|
+
{
|
|
581
|
+
"type": "FDADrugAdverseEventTool",
|
|
582
|
+
"name": "FAERS_count_death_related_by_drug",
|
|
583
|
+
"description": "Count adverse events associated with patient death for a given drug. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
584
|
+
"parameter": {
|
|
585
|
+
"type": "object",
|
|
586
|
+
"properties": {
|
|
587
|
+
"medicinalproduct": {
|
|
588
|
+
"type": "string",
|
|
589
|
+
"description": "Drug name."
|
|
590
|
+
}
|
|
591
|
+
},
|
|
592
|
+
"required": [
|
|
593
|
+
"medicinalproduct"
|
|
594
|
+
]
|
|
309
595
|
},
|
|
310
|
-
{
|
|
311
|
-
"
|
|
312
|
-
|
|
313
|
-
|
|
314
|
-
|
|
315
|
-
"
|
|
316
|
-
|
|
317
|
-
|
|
318
|
-
"patientsex": { "type": "string", "enum": ["Male","Female"], "description": "Filter by patient sex." },
|
|
319
|
-
"patientagegroup": { "type": "string", "enum": ["Neonate","Infant","Child","Adolescent","Adult","Elderly"], "description": "Filter by patient age group." },
|
|
320
|
-
"occurcountry": { "type": "string", "pattern": "^[A-Z]{2}$", "description": "Filter by ISO2 country code of occurrence." },
|
|
321
|
-
"serious": { "type": "string", "enum": ["Yes","No"], "description": "Filter by seriousness classification." },
|
|
322
|
-
"seriousnessdeath": { "type": "string", "enum": ["Yes","No"], "description": "Filter for fatal outcomes." }
|
|
323
|
-
},
|
|
324
|
-
"required": ["medicinalproducts"]
|
|
596
|
+
"fields": {
|
|
597
|
+
"search_fields": {
|
|
598
|
+
"medicinalproduct": [
|
|
599
|
+
"patient.drug.medicinalproduct"
|
|
600
|
+
],
|
|
601
|
+
"seriousnessdeath": [
|
|
602
|
+
"seriousnessdeath"
|
|
603
|
+
]
|
|
325
604
|
},
|
|
326
|
-
"
|
|
327
|
-
"
|
|
328
|
-
|
|
329
|
-
|
|
330
|
-
|
|
331
|
-
"
|
|
332
|
-
"
|
|
333
|
-
|
|
334
|
-
},
|
|
335
|
-
"return_fields": ["patient.reaction.reactionmeddrapt.exact"]
|
|
605
|
+
"return_fields": [
|
|
606
|
+
"seriousnessdeath"
|
|
607
|
+
],
|
|
608
|
+
"return_fields_mapping": {
|
|
609
|
+
"seriousnessdeath": {
|
|
610
|
+
"1": "death",
|
|
611
|
+
"2": "alive"
|
|
612
|
+
}
|
|
336
613
|
}
|
|
614
|
+
}
|
|
615
|
+
},
|
|
616
|
+
{
|
|
617
|
+
"type": "FDACountAdditiveReactionsTool",
|
|
618
|
+
"name": "FAERS_count_additive_adverse_reactions",
|
|
619
|
+
"description": "Additive multi-drug data: Aggregate adverse reaction counts across specified medicinal products, stratified by demographics, seriousness, and outcomes. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
620
|
+
"parameter": {
|
|
621
|
+
"type": "object",
|
|
622
|
+
"properties": {
|
|
623
|
+
"medicinalproducts": {
|
|
624
|
+
"type": "array",
|
|
625
|
+
"items": {
|
|
626
|
+
"type": "string"
|
|
627
|
+
},
|
|
628
|
+
"description": "Array of medicinal product names."
|
|
629
|
+
},
|
|
630
|
+
"patientsex": {
|
|
631
|
+
"type": "string",
|
|
632
|
+
"enum": [
|
|
633
|
+
"Male",
|
|
634
|
+
"Female"
|
|
635
|
+
],
|
|
636
|
+
"description": "Filter by patient sex."
|
|
637
|
+
},
|
|
638
|
+
"patientagegroup": {
|
|
639
|
+
"type": "string",
|
|
640
|
+
"enum": [
|
|
641
|
+
"Neonate",
|
|
642
|
+
"Infant",
|
|
643
|
+
"Child",
|
|
644
|
+
"Adolescent",
|
|
645
|
+
"Adult",
|
|
646
|
+
"Elderly"
|
|
647
|
+
],
|
|
648
|
+
"description": "Filter by patient age group."
|
|
649
|
+
},
|
|
650
|
+
"occurcountry": {
|
|
651
|
+
"type": "string",
|
|
652
|
+
"pattern": "^[A-Z]{2}$",
|
|
653
|
+
"description": "Filter by ISO2 country code of occurrence."
|
|
654
|
+
},
|
|
655
|
+
"serious": {
|
|
656
|
+
"type": "string",
|
|
657
|
+
"enum": [
|
|
658
|
+
"Yes",
|
|
659
|
+
"No"
|
|
660
|
+
],
|
|
661
|
+
"description": "Filter by seriousness classification."
|
|
662
|
+
},
|
|
663
|
+
"seriousnessdeath": {
|
|
664
|
+
"type": "string",
|
|
665
|
+
"enum": [
|
|
666
|
+
"Yes",
|
|
667
|
+
"No"
|
|
668
|
+
],
|
|
669
|
+
"description": "Filter for fatal outcomes."
|
|
670
|
+
}
|
|
671
|
+
},
|
|
672
|
+
"required": [
|
|
673
|
+
"medicinalproducts",
|
|
674
|
+
"patientsex",
|
|
675
|
+
"patientagegroup",
|
|
676
|
+
"occurcountry",
|
|
677
|
+
"serious",
|
|
678
|
+
"seriousnessdeath"
|
|
679
|
+
]
|
|
337
680
|
},
|
|
338
|
-
{
|
|
339
|
-
"
|
|
340
|
-
|
|
341
|
-
|
|
342
|
-
|
|
343
|
-
"
|
|
344
|
-
|
|
345
|
-
|
|
346
|
-
|
|
347
|
-
"patientagegroup"
|
|
348
|
-
|
|
349
|
-
|
|
350
|
-
|
|
681
|
+
"fields": {
|
|
682
|
+
"search_fields": {
|
|
683
|
+
"medicinalproducts": [
|
|
684
|
+
"patient.drug.medicinalproduct"
|
|
685
|
+
],
|
|
686
|
+
"patientsex": [
|
|
687
|
+
"patient.patientsex"
|
|
688
|
+
],
|
|
689
|
+
"patientagegroup": [
|
|
690
|
+
"patient.patientagegroup"
|
|
691
|
+
],
|
|
692
|
+
"occurcountry": [
|
|
693
|
+
"occurcountry"
|
|
694
|
+
],
|
|
695
|
+
"serious": [
|
|
696
|
+
"serious"
|
|
697
|
+
],
|
|
698
|
+
"seriousnessdeath": [
|
|
699
|
+
"seriousnessdeath"
|
|
700
|
+
]
|
|
351
701
|
},
|
|
352
|
-
"
|
|
353
|
-
"
|
|
354
|
-
|
|
355
|
-
|
|
356
|
-
|
|
357
|
-
|
|
358
|
-
|
|
359
|
-
|
|
360
|
-
|
|
702
|
+
"return_fields": [
|
|
703
|
+
"patient.reaction.reactionmeddrapt.exact"
|
|
704
|
+
]
|
|
705
|
+
}
|
|
706
|
+
},
|
|
707
|
+
{
|
|
708
|
+
"type": "FDACountAdditiveReactionsTool",
|
|
709
|
+
"name": "FAERS_count_additive_event_reports_by_country",
|
|
710
|
+
"description": "Additive multi-drug data: Aggregate report counts by country of occurrence across specified medicinal products. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
711
|
+
"parameter": {
|
|
712
|
+
"type": "object",
|
|
713
|
+
"properties": {
|
|
714
|
+
"medicinalproducts": {
|
|
715
|
+
"type": "array",
|
|
716
|
+
"items": {
|
|
717
|
+
"type": "string"
|
|
718
|
+
},
|
|
719
|
+
"description": "Array of medicinal product names."
|
|
720
|
+
},
|
|
721
|
+
"patientsex": {
|
|
722
|
+
"type": "string",
|
|
723
|
+
"enum": [
|
|
724
|
+
"Male",
|
|
725
|
+
"Female"
|
|
726
|
+
],
|
|
727
|
+
"description": "Filter by sex."
|
|
728
|
+
},
|
|
729
|
+
"patientagegroup": {
|
|
730
|
+
"type": "string",
|
|
731
|
+
"enum": [
|
|
732
|
+
"Neonate",
|
|
733
|
+
"Infant",
|
|
734
|
+
"Child",
|
|
735
|
+
"Adolescent",
|
|
736
|
+
"Adult",
|
|
737
|
+
"Elderly"
|
|
738
|
+
],
|
|
739
|
+
"description": "Filter by age group."
|
|
740
|
+
},
|
|
741
|
+
"serious": {
|
|
742
|
+
"type": "string",
|
|
743
|
+
"enum": [
|
|
744
|
+
"Yes",
|
|
745
|
+
"No"
|
|
746
|
+
],
|
|
747
|
+
"description": "Filter by seriousness."
|
|
748
|
+
}
|
|
749
|
+
},
|
|
750
|
+
"required": [
|
|
751
|
+
"medicinalproducts",
|
|
752
|
+
"patientsex",
|
|
753
|
+
"patientagegroup",
|
|
754
|
+
"serious"
|
|
755
|
+
]
|
|
361
756
|
},
|
|
362
|
-
{
|
|
363
|
-
"
|
|
364
|
-
|
|
365
|
-
|
|
366
|
-
|
|
367
|
-
"
|
|
368
|
-
|
|
369
|
-
|
|
370
|
-
|
|
371
|
-
"patientagegroup"
|
|
372
|
-
|
|
373
|
-
|
|
374
|
-
|
|
757
|
+
"fields": {
|
|
758
|
+
"search_fields": {
|
|
759
|
+
"medicinalproducts": [
|
|
760
|
+
"patient.drug.medicinalproduct"
|
|
761
|
+
],
|
|
762
|
+
"patientsex": [
|
|
763
|
+
"patient.patientsex"
|
|
764
|
+
],
|
|
765
|
+
"patientagegroup": [
|
|
766
|
+
"patient.patientagegroup"
|
|
767
|
+
],
|
|
768
|
+
"serious": [
|
|
769
|
+
"serious"
|
|
770
|
+
]
|
|
375
771
|
},
|
|
376
|
-
"
|
|
377
|
-
"
|
|
378
|
-
|
|
379
|
-
|
|
380
|
-
|
|
381
|
-
|
|
382
|
-
|
|
383
|
-
|
|
384
|
-
|
|
772
|
+
"return_fields": [
|
|
773
|
+
"occurcountry.exact"
|
|
774
|
+
]
|
|
775
|
+
}
|
|
776
|
+
},
|
|
777
|
+
{
|
|
778
|
+
"type": "FDACountAdditiveReactionsTool",
|
|
779
|
+
"name": "FAERS_count_additive_reports_by_reporter_country",
|
|
780
|
+
"description": "Additive multi-drug data: Aggregate adverse event reports by primary reporter country across medicinal products. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
781
|
+
"parameter": {
|
|
782
|
+
"type": "object",
|
|
783
|
+
"properties": {
|
|
784
|
+
"medicinalproducts": {
|
|
785
|
+
"type": "array",
|
|
786
|
+
"items": {
|
|
787
|
+
"type": "string"
|
|
788
|
+
},
|
|
789
|
+
"description": "Array of medicinal product names."
|
|
790
|
+
},
|
|
791
|
+
"patientsex": {
|
|
792
|
+
"type": "string",
|
|
793
|
+
"enum": [
|
|
794
|
+
"Male",
|
|
795
|
+
"Female"
|
|
796
|
+
],
|
|
797
|
+
"description": "Filter by sex."
|
|
798
|
+
},
|
|
799
|
+
"patientagegroup": {
|
|
800
|
+
"type": "string",
|
|
801
|
+
"enum": [
|
|
802
|
+
"Neonate",
|
|
803
|
+
"Infant",
|
|
804
|
+
"Child",
|
|
805
|
+
"Adolescent",
|
|
806
|
+
"Adult",
|
|
807
|
+
"Elderly"
|
|
808
|
+
],
|
|
809
|
+
"description": "Filter by age group."
|
|
810
|
+
},
|
|
811
|
+
"serious": {
|
|
812
|
+
"type": "string",
|
|
813
|
+
"enum": [
|
|
814
|
+
"Yes",
|
|
815
|
+
"No"
|
|
816
|
+
],
|
|
817
|
+
"description": "Filter by seriousness."
|
|
818
|
+
}
|
|
819
|
+
},
|
|
820
|
+
"required": [
|
|
821
|
+
"medicinalproducts",
|
|
822
|
+
"patientsex",
|
|
823
|
+
"patientagegroup",
|
|
824
|
+
"serious"
|
|
825
|
+
]
|
|
826
|
+
},
|
|
827
|
+
"fields": {
|
|
828
|
+
"search_fields": {
|
|
829
|
+
"medicinalproducts": [
|
|
830
|
+
"patient.drug.medicinalproduct"
|
|
831
|
+
],
|
|
832
|
+
"patientsex": [
|
|
833
|
+
"patient.patientsex"
|
|
834
|
+
],
|
|
835
|
+
"patientagegroup": [
|
|
836
|
+
"patient.patientagegroup"
|
|
837
|
+
],
|
|
838
|
+
"serious": [
|
|
839
|
+
"serious"
|
|
840
|
+
]
|
|
841
|
+
},
|
|
842
|
+
"return_fields": [
|
|
843
|
+
"primarysource.reportercountry.exact"
|
|
844
|
+
]
|
|
845
|
+
}
|
|
846
|
+
},
|
|
847
|
+
{
|
|
848
|
+
"type": "FDACountAdditiveReactionsTool",
|
|
849
|
+
"name": "FAERS_count_additive_seriousness_classification",
|
|
850
|
+
"description": "Additive multi-drug data: Quantify serious vs non-serious classifications across medicinal products, annotated per regulatory definitions. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
851
|
+
"parameter": {
|
|
852
|
+
"type": "object",
|
|
853
|
+
"properties": {
|
|
854
|
+
"medicinalproducts": {
|
|
855
|
+
"type": "array",
|
|
856
|
+
"items": {
|
|
857
|
+
"type": "string"
|
|
858
|
+
},
|
|
859
|
+
"description": "Array of medicinal product names."
|
|
860
|
+
},
|
|
861
|
+
"patientsex": {
|
|
862
|
+
"type": "string",
|
|
863
|
+
"enum": [
|
|
864
|
+
"Male",
|
|
865
|
+
"Female"
|
|
866
|
+
],
|
|
867
|
+
"description": "Filter by sex."
|
|
868
|
+
},
|
|
869
|
+
"patientagegroup": {
|
|
870
|
+
"type": "string",
|
|
871
|
+
"enum": [
|
|
872
|
+
"Neonate",
|
|
873
|
+
"Infant",
|
|
874
|
+
"Child",
|
|
875
|
+
"Adolescent",
|
|
876
|
+
"Adult",
|
|
877
|
+
"Elderly"
|
|
878
|
+
],
|
|
879
|
+
"description": "Filter by age group."
|
|
880
|
+
},
|
|
881
|
+
"occurcountry": {
|
|
882
|
+
"type": "string",
|
|
883
|
+
"pattern": "^[A-Z]{2}$",
|
|
884
|
+
"description": "ISO2 country code filter."
|
|
885
|
+
}
|
|
886
|
+
},
|
|
887
|
+
"required": [
|
|
888
|
+
"medicinalproducts",
|
|
889
|
+
"patientsex",
|
|
890
|
+
"patientagegroup",
|
|
891
|
+
"occurcountry"
|
|
892
|
+
]
|
|
385
893
|
},
|
|
386
|
-
{
|
|
387
|
-
"
|
|
388
|
-
|
|
389
|
-
|
|
390
|
-
|
|
391
|
-
"
|
|
392
|
-
|
|
393
|
-
|
|
394
|
-
|
|
395
|
-
"patientagegroup"
|
|
396
|
-
|
|
397
|
-
|
|
398
|
-
|
|
894
|
+
"fields": {
|
|
895
|
+
"search_fields": {
|
|
896
|
+
"medicinalproducts": [
|
|
897
|
+
"patient.drug.medicinalproduct"
|
|
898
|
+
],
|
|
899
|
+
"patientsex": [
|
|
900
|
+
"patient.patientsex"
|
|
901
|
+
],
|
|
902
|
+
"patientagegroup": [
|
|
903
|
+
"patient.patientagegroup"
|
|
904
|
+
],
|
|
905
|
+
"occurcountry": [
|
|
906
|
+
"occurcountry"
|
|
907
|
+
]
|
|
399
908
|
},
|
|
400
|
-
"
|
|
401
|
-
"
|
|
402
|
-
|
|
403
|
-
|
|
404
|
-
|
|
405
|
-
"
|
|
406
|
-
|
|
407
|
-
|
|
408
|
-
"return_fields_mapping": { "serious": { "1": "Serious", "2": "Non-serious" } }
|
|
909
|
+
"return_fields": [
|
|
910
|
+
"serious"
|
|
911
|
+
],
|
|
912
|
+
"return_fields_mapping": {
|
|
913
|
+
"serious": {
|
|
914
|
+
"1": "Serious",
|
|
915
|
+
"2": "Non-serious"
|
|
916
|
+
}
|
|
409
917
|
}
|
|
918
|
+
}
|
|
919
|
+
},
|
|
920
|
+
{
|
|
921
|
+
"type": "FDACountAdditiveReactionsTool",
|
|
922
|
+
"name": "FAERS_count_additive_reaction_outcomes",
|
|
923
|
+
"description": "Additive multi-drug data: Determine reaction outcome counts (e.g., recovered, resolving, fatal) across medicinal products using standardized outcome mappings. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
924
|
+
"parameter": {
|
|
925
|
+
"type": "object",
|
|
926
|
+
"properties": {
|
|
927
|
+
"medicinalproducts": {
|
|
928
|
+
"type": "array",
|
|
929
|
+
"items": {
|
|
930
|
+
"type": "string"
|
|
931
|
+
},
|
|
932
|
+
"description": "Array of medicinal product names."
|
|
933
|
+
},
|
|
934
|
+
"patientsex": {
|
|
935
|
+
"type": "string",
|
|
936
|
+
"enum": [
|
|
937
|
+
"Male",
|
|
938
|
+
"Female"
|
|
939
|
+
]
|
|
940
|
+
},
|
|
941
|
+
"patientagegroup": {
|
|
942
|
+
"type": "string",
|
|
943
|
+
"enum": [
|
|
944
|
+
"Neonate",
|
|
945
|
+
"Infant",
|
|
946
|
+
"Child",
|
|
947
|
+
"Adolescent",
|
|
948
|
+
"Adult",
|
|
949
|
+
"Elderly"
|
|
950
|
+
]
|
|
951
|
+
},
|
|
952
|
+
"occurcountry": {
|
|
953
|
+
"type": "string",
|
|
954
|
+
"pattern": "^[A-Z]{2}$"
|
|
955
|
+
}
|
|
956
|
+
},
|
|
957
|
+
"required": [
|
|
958
|
+
"medicinalproducts",
|
|
959
|
+
"patientsex",
|
|
960
|
+
"patientagegroup",
|
|
961
|
+
"occurcountry"
|
|
962
|
+
]
|
|
410
963
|
},
|
|
411
|
-
{
|
|
412
|
-
"
|
|
413
|
-
|
|
414
|
-
|
|
415
|
-
|
|
416
|
-
"
|
|
417
|
-
|
|
418
|
-
|
|
419
|
-
|
|
420
|
-
"patientagegroup"
|
|
421
|
-
|
|
422
|
-
|
|
423
|
-
|
|
964
|
+
"fields": {
|
|
965
|
+
"search_fields": {
|
|
966
|
+
"medicinalproducts": [
|
|
967
|
+
"patient.drug.medicinalproduct"
|
|
968
|
+
],
|
|
969
|
+
"patientsex": [
|
|
970
|
+
"patient.patientsex"
|
|
971
|
+
],
|
|
972
|
+
"patientagegroup": [
|
|
973
|
+
"patient.patientagegroup"
|
|
974
|
+
],
|
|
975
|
+
"occurcountry": [
|
|
976
|
+
"occurcountry"
|
|
977
|
+
]
|
|
424
978
|
},
|
|
425
|
-
"
|
|
426
|
-
"
|
|
427
|
-
|
|
428
|
-
|
|
429
|
-
|
|
430
|
-
"
|
|
431
|
-
|
|
432
|
-
|
|
433
|
-
|
|
434
|
-
"
|
|
435
|
-
|
|
436
|
-
"2": "Recovering/resolving",
|
|
437
|
-
"3": "Not recovered/not resolved",
|
|
438
|
-
"4": "Recovered/resolved with sequelae",
|
|
439
|
-
"5": "Fatal",
|
|
440
|
-
"6": "Unknown"
|
|
441
|
-
}
|
|
979
|
+
"return_fields": [
|
|
980
|
+
"patient.reaction.reactionoutcome"
|
|
981
|
+
],
|
|
982
|
+
"return_fields_mapping": {
|
|
983
|
+
"patient.reaction.reactionoutcome": {
|
|
984
|
+
"1": "Recovered/resolved",
|
|
985
|
+
"2": "Recovering/resolving",
|
|
986
|
+
"3": "Not recovered/not resolved",
|
|
987
|
+
"4": "Recovered/resolved with sequelae",
|
|
988
|
+
"5": "Fatal",
|
|
989
|
+
"6": "Unknown"
|
|
442
990
|
}
|
|
443
991
|
}
|
|
992
|
+
}
|
|
993
|
+
},
|
|
994
|
+
{
|
|
995
|
+
"type": "FDACountAdditiveReactionsTool",
|
|
996
|
+
"name": "FAERS_count_additive_administration_routes",
|
|
997
|
+
"description": "Additive multi-drug data: Enumerate and count administration routes for adverse events across specified medicinal products, using standardized route codes. Data source: FDA Adverse Event Reporting System (FAERS).",
|
|
998
|
+
"parameter": {
|
|
999
|
+
"type": "object",
|
|
1000
|
+
"properties": {
|
|
1001
|
+
"medicinalproducts": {
|
|
1002
|
+
"type": "array",
|
|
1003
|
+
"items": {
|
|
1004
|
+
"type": "string"
|
|
1005
|
+
},
|
|
1006
|
+
"description": "Array of medicinal product names."
|
|
1007
|
+
},
|
|
1008
|
+
"serious": {
|
|
1009
|
+
"type": "string",
|
|
1010
|
+
"enum": [
|
|
1011
|
+
"Yes",
|
|
1012
|
+
"No"
|
|
1013
|
+
],
|
|
1014
|
+
"description": "Filter by seriousness."
|
|
1015
|
+
}
|
|
1016
|
+
},
|
|
1017
|
+
"required": [
|
|
1018
|
+
"medicinalproducts",
|
|
1019
|
+
"serious"
|
|
1020
|
+
]
|
|
444
1021
|
},
|
|
445
|
-
{
|
|
446
|
-
"
|
|
447
|
-
|
|
448
|
-
|
|
449
|
-
|
|
450
|
-
"
|
|
451
|
-
|
|
452
|
-
|
|
453
|
-
"serious": { "type": "string", "enum": ["Yes","No"], "description": "Filter by seriousness." }
|
|
454
|
-
},
|
|
455
|
-
"required": ["medicinalproducts"]
|
|
1022
|
+
"fields": {
|
|
1023
|
+
"search_fields": {
|
|
1024
|
+
"medicinalproducts": [
|
|
1025
|
+
"patient.drug.medicinalproduct"
|
|
1026
|
+
],
|
|
1027
|
+
"serious": [
|
|
1028
|
+
"serious"
|
|
1029
|
+
]
|
|
456
1030
|
},
|
|
457
|
-
"
|
|
458
|
-
"
|
|
459
|
-
|
|
460
|
-
|
|
461
|
-
|
|
462
|
-
|
|
463
|
-
|
|
464
|
-
"
|
|
465
|
-
|
|
466
|
-
|
|
467
|
-
|
|
468
|
-
|
|
469
|
-
|
|
470
|
-
|
|
471
|
-
|
|
472
|
-
|
|
473
|
-
|
|
474
|
-
|
|
475
|
-
|
|
476
|
-
|
|
477
|
-
|
|
478
|
-
|
|
479
|
-
|
|
480
|
-
|
|
481
|
-
|
|
482
|
-
|
|
483
|
-
|
|
484
|
-
|
|
485
|
-
|
|
486
|
-
|
|
487
|
-
|
|
1031
|
+
"return_fields": [
|
|
1032
|
+
"patient.drug.drugadministrationroute.exact"
|
|
1033
|
+
],
|
|
1034
|
+
"return_fields_mapping": {
|
|
1035
|
+
"patient.drug.drugadministrationroute.exact": {
|
|
1036
|
+
"001": "Auricular (otic)",
|
|
1037
|
+
"002": "Buccal",
|
|
1038
|
+
"003": "Cutaneous",
|
|
1039
|
+
"004": "Dental",
|
|
1040
|
+
"005": "Endocervical",
|
|
1041
|
+
"006": "Endosinusial",
|
|
1042
|
+
"007": "Endotracheal",
|
|
1043
|
+
"008": "Epidural",
|
|
1044
|
+
"009": "Extra-amniotic",
|
|
1045
|
+
"010": "Hemodialysis",
|
|
1046
|
+
"011": "Intra corpus cavernosum",
|
|
1047
|
+
"012": "Intra-amniotic",
|
|
1048
|
+
"013": "Intra-arterial",
|
|
1049
|
+
"014": "Intra-articular",
|
|
1050
|
+
"015": "Intra-uterine",
|
|
1051
|
+
"016": "Intracardiac",
|
|
1052
|
+
"017": "Intracavernous",
|
|
1053
|
+
"018": "Intracerebral",
|
|
1054
|
+
"019": "Intracervical",
|
|
1055
|
+
"020": "Intracisternal",
|
|
1056
|
+
"021": "Intracorneal",
|
|
1057
|
+
"022": "Intracoronary",
|
|
1058
|
+
"023": "Intradermal",
|
|
1059
|
+
"024": "Intradiscal (intraspinal)",
|
|
1060
|
+
"025": "Intrahepatic",
|
|
1061
|
+
"026": "Intralesional",
|
|
1062
|
+
"027": "Intralymphatic",
|
|
1063
|
+
"028": "Intramedullar (bone marrow)",
|
|
1064
|
+
"029": "Intrameningeal",
|
|
1065
|
+
"030": "Intramuscular",
|
|
1066
|
+
"031": "Intraocular",
|
|
1067
|
+
"032": "Intrapericardial",
|
|
1068
|
+
"033": "Intraperitoneal",
|
|
1069
|
+
"034": "Intrapleural",
|
|
1070
|
+
"035": "Intrasynovial",
|
|
1071
|
+
"036": "Intratumor",
|
|
1072
|
+
"037": "Intrathecal",
|
|
1073
|
+
"038": "Intrathoracic",
|
|
1074
|
+
"039": "Intratracheal",
|
|
1075
|
+
"040": "Intravenous bolus",
|
|
1076
|
+
"041": "Intravenous drip",
|
|
1077
|
+
"042": "Intravenous (not otherwise specified)",
|
|
1078
|
+
"043": "Intravesical",
|
|
1079
|
+
"044": "Iontophoresis",
|
|
1080
|
+
"045": "Nasal",
|
|
1081
|
+
"046": "Occlusive dressing technique",
|
|
1082
|
+
"047": "Ophthalmic",
|
|
1083
|
+
"048": "Oral",
|
|
1084
|
+
"049": "Oropharingeal",
|
|
1085
|
+
"050": "Other",
|
|
1086
|
+
"051": "Parenteral",
|
|
1087
|
+
"052": "Periarticular",
|
|
1088
|
+
"053": "Perineural",
|
|
1089
|
+
"054": "Rectal",
|
|
1090
|
+
"055": "Respiratory (inhalation)",
|
|
1091
|
+
"056": "Retrobulbar",
|
|
1092
|
+
"057": "Sunconjunctival",
|
|
1093
|
+
"058": "Subcutaneous",
|
|
1094
|
+
"059": "Subdermal",
|
|
1095
|
+
"060": "Sublingual",
|
|
1096
|
+
"061": "Topical",
|
|
1097
|
+
"062": "Transdermal",
|
|
1098
|
+
"063": "Transmammary",
|
|
1099
|
+
"064": "Transplacental",
|
|
1100
|
+
"065": "Unknown",
|
|
1101
|
+
"066": "Urethral",
|
|
1102
|
+
"067": "Vaginal"
|
|
488
1103
|
}
|
|
489
1104
|
}
|
|
490
1105
|
}
|
|
491
|
-
|
|
1106
|
+
}
|
|
1107
|
+
]
|