csrlite 0.2.1__py3-none-any.whl → 0.3.0__py3-none-any.whl

csrlite/cm/cm_summary.py

@@ -0,0 +1,327 @@
+# pyre-strict
+"""
+Concomitant Medications (CM) Summary Functions
+
+This module provides a three-step pipeline for CM summary analysis:
+- cm_summary_ard: Generate Analysis Results Data (ARD) in long format
+- cm_summary_df: Transform ARD to wide display format
+- cm_summary_rtf: Generate formatted RTF output
+- cm_summary: Complete pipeline wrapper
+- study_plan_to_cm_summary: Batch generation from StudyPlan
+
+Applications:
+- Summary of Concomitant Medications
+- Summary of Prior Medications
+"""
+
+from pathlib import Path
+
+import polars as pl
+from rtflite import RTFDocument
+
+from ..common.count import count_subject, count_subject_with_observation
+from ..common.parse import StudyPlanParser
+from ..common.plan import StudyPlan
+from ..common.rtf import create_rtf_table_n_pct
+from ..common.utils import apply_common_filters
+
+
+def study_plan_to_cm_summary(
+    study_plan: StudyPlan,
+) -> list[str]:
+    """
+    Generate CM summary RTF outputs for all analyses defined in StudyPlan.
+
+    Args:
+        study_plan: StudyPlan object with loaded datasets and analysis specifications
+
+    Returns:
+        list[str]: List of paths to generated RTF files
+    """
+
+    # Meta data
+    analysis = "cm_summary"
+    analysis_label = "Summary of Concomitant Medications"
+    output_dir = study_plan.output_dir
+    footnote = ["Every participant is counted a single time for each applicable row and column."]
+    source = None
+
+    population_df_name = "adsl"
+    observation_df_name = "adcm"
+
+    id = ("USUBJID", "Subject ID")
+    total = True
+    missing_group = "error"
+
+    # Create output directory if it doesn't exist
+    Path(output_dir).mkdir(parents=True, exist_ok=True)
+
+    # Initialize parser
+    parser = StudyPlanParser(study_plan)
+
+    # Get expanded plan DataFrame
+    plan_df = study_plan.get_plan_df()
+
+    # Filter for CM summary analyses
+    cm_plans = plan_df.filter(pl.col("analysis") == analysis)
+
+    rtf_files = []
+
+    # Generate RTF for each analysis
+    for row in cm_plans.iter_rows(named=True):
+        population = row["population"]
+        observation = row.get("observation")
+        parameter = row.get("parameter")
+        group = row.get("group")
+
+        # Validate group is specified
+        if group is None:
+            raise ValueError(
+                f"Group not specified in YAML "
+                f"population={population}, observation={observation}, parameter={parameter}. "
+                "Please add group to your YAML plan."
+            )
+
+        # Get datasets using parser
+        population_df, observation_df = parser.get_datasets(population_df_name, observation_df_name)
+
+        # Get filters and configuration using parser
+        population_filter = parser.get_population_filter(population)
+
+        # Handle parameters (variables to summarize)
+        if parameter:
+            param_names, param_filters, param_labels, _ = parser.get_parameter_info(parameter)
+        else:
+            # Default to summarizing "Any Medication" if no parameter specified
+            # But usually cm_summary needs parameters defining what to count
+            # Use a default generic filter if none provided
+            param_filters = ["1=1"]
+            param_labels = ["Any Medication"]
+
+        obs_filter = parser.get_observation_filter(observation)
+        group_var_name, group_labels = parser.get_group_info(group)
+
+        # Build variables as list of tuples [(filter, label)]
+        variables_list = list(zip(param_filters, param_labels))
+
+        # Build group tuple (variable_name, label)
+        group_var_label = group_labels[0] if group_labels else group_var_name
+        group_tuple = (group_var_name, group_var_label)
+
+        # Build title
+        title_parts = [analysis_label]
+        if observation:
+            obs_kw = study_plan.keywords.observations.get(observation)
+            if obs_kw and obs_kw.label:
+                title_parts.append(obs_kw.label)
+
+        pop_kw = study_plan.keywords.populations.get(population)
+        if pop_kw and pop_kw.label:
+            title_parts.append(pop_kw.label)
+
+        # Build output filename
+        filename = f"{analysis}_{population}"
+        if observation:
+            filename += f"_{observation}"
+        if parameter:
+            filename += f"_{parameter.replace(';', '_')}"
+        filename += ".rtf"
+        output_file = str(Path(output_dir) / filename)
+
+        # Generate RTF
+        rtf_path = cm_summary(
+            population=population_df,
+            observation=observation_df,
+            population_filter=population_filter,
+            observation_filter=obs_filter,
+            id=id,
+            group=group_tuple,
+            variables=variables_list,
+            title=title_parts,
+            footnote=footnote,
+            source=source,
+            output_file=output_file,
+            total=total,
+            missing_group=missing_group,
+        )
+
+        rtf_files.append(rtf_path)
+
+    return rtf_files
+
+
+def cm_summary_ard(
+    population: pl.DataFrame,
+    observation: pl.DataFrame,
+    population_filter: str | None,
+    observation_filter: str | None,
+    id: tuple[str, str],
+    group: tuple[str, str],
+    variables: list[tuple[str, str]],
+    total: bool,
+    missing_group: str,
+) -> pl.DataFrame:
+    """
+    Generate Analysis Results Data (ARD) for CM summary analysis.
+    """
+    # Reuse the same logic logic as ae_summary_ard since it's generic counting
+    # But checking if we should duplicate code or import?
+    # For now, duplication allows independence (e.g. if CM specific logic is needed later)
+
+    pop_var_name = "Participants in population"
+    id_var_name, id_var_label = id
+    group_var_name, group_var_label = group
+
+    population_filtered, observation_to_filter = apply_common_filters(
+        population=population,
+        observation=observation,
+        population_filter=population_filter,
+        observation_filter=observation_filter,
+    )
+
+    assert observation_to_filter is not None
+
+    observation_filtered_list = []
+    for variable_filter, variable_label in variables:
+        obs_filtered = (
+            observation_to_filter.filter(
+                pl.col(id_var_name).is_in(population_filtered[id_var_name].to_list())
+            )
+            .filter(pl.sql_expr(variable_filter))
+            .with_columns(pl.lit(variable_label).alias("__index__"))
+        )
+        observation_filtered_list.append(obs_filtered)
+
+    if observation_filtered_list:
+        observation_filtered = pl.concat(observation_filtered_list)
+    else:
+        # Handle case with no variables (empty df with correct schema)
+        observation_filtered = observation_to_filter.clear().with_columns(
+            pl.lit("").alias("__index__")
+        )
+
+    # Population counts
+    n_pop = count_subject(
+        population=population_filtered,
+        id=id_var_name,
+        group=group_var_name,
+        total=total,
+        missing_group=missing_group,
+    )
+
+    n_pop = n_pop.select(
+        pl.lit(pop_var_name).alias("__index__"),
+        pl.col(group_var_name).alias("__group__"),
+        pl.col("n_subj_pop").cast(pl.String).alias("__value__"),
+    )
+
+    n_empty = n_pop.select(
+        pl.lit("").alias("__index__"), pl.col("__group__"), pl.lit("").alias("__value__")
+    )
+
+    # Observation counts
+    n_obs = count_subject_with_observation(
+        population=population_filtered,
+        observation=observation_filtered,
+        id=id_var_name,
+        group=group_var_name,
+        total=total,
+        variable="__index__",
+        missing_group=missing_group,
+    )
+
+    n_obs = n_obs.select(
+        pl.col("__index__"),
+        pl.col(group_var_name).alias("__group__"),
+        pl.col("n_pct_subj_fmt").alias("__value__"),
+    )
+
+    res = pl.concat([n_pop, n_empty, n_obs])
+
+    variable_labels = [label for _, label in variables]
+    ordered_categories = [pop_var_name, ""] + variable_labels
+
+    # Ensure all categories are present in Enum
+    res = res.with_columns(pl.col("__index__").cast(pl.Enum(ordered_categories))).sort(
+        "__index__", "__group__"
+    )
+
+    return res
+
+
+def cm_summary_df(ard: pl.DataFrame) -> pl.DataFrame:
+    """Transform CM summary ARD into display-ready DataFrame."""
+    df_wide = ard.pivot(index="__index__", on="__group__", values="__value__")
+    return df_wide
+
+
+def cm_summary_rtf(
+    df: pl.DataFrame,
+    title: list[str],
+    footnote: list[str] | None,
+    source: list[str] | None,
+    col_rel_width: list[float] | None = None,
+) -> RTFDocument:
+    """Generate RTF table from CM summary display DataFrame."""
+    df_rtf = df.rename({"__index__": ""})
+    n_cols = len(df_rtf.columns)
+    col_header_1 = list(df_rtf.columns)
+    col_header_2 = [""] + ["n (%)"] * (n_cols - 1)
+
+    if col_rel_width is None:
+        col_widths = [float(n_cols - 1)] + [1.0] * (n_cols - 1)
+    else:
+        col_widths = col_rel_width
+
+    return create_rtf_table_n_pct(
+        df=df_rtf,
+        col_header_1=col_header_1,
+        col_header_2=col_header_2,
+        col_widths=col_widths,
+        title=title,
+        footnote=footnote,
+        source=source,
+    )
+
+
+def cm_summary(
+    population: pl.DataFrame,
+    observation: pl.DataFrame,
+    population_filter: str | None,
+    observation_filter: str | None,
+    id: tuple[str, str],
+    group: tuple[str, str],
+    variables: list[tuple[str, str]],
+    title: list[str],
+    footnote: list[str] | None,
+    source: list[str] | None,
+    output_file: str,
+    total: bool = True,
+    col_rel_width: list[float] | None = None,
+    missing_group: str = "error",
+) -> str:
+    """Complete CM summary pipeline wrapper."""
+    ard = cm_summary_ard(
+        population=population,
+        observation=observation,
+        population_filter=population_filter,
+        observation_filter=observation_filter,
+        id=id,
+        group=group,
+        variables=variables,
+        total=total,
+        missing_group=missing_group,
+    )
+
+    df = cm_summary_df(ard)
+
+    rtf_doc = cm_summary_rtf(
+        df=df,
+        title=title,
+        footnote=footnote,
+        source=source,
+        col_rel_width=col_rel_width,
+    )
+    rtf_doc.write_rtf(output_file)
+
+    return output_file

csrlite/common/config.py

@@ -1,34 +1,34 @@
-# pyre-strict
-"""
-Central configuration for csrlite.
-"""
-
-from typing import Literal, Optional
-
-from pydantic import BaseModel, ConfigDict, Field
-
-
-class CsrLiteConfig(BaseModel):
-    """
-    Global configuration for csrlite library.
-    """
-
-    # Column Name Defaults
-    id_col: str = Field(default="USUBJID", description="Subject Identifier Column")
-    group_col: Optional[str] = Field(default=None, description="Treatment Group Column")
-
-    # Missing Value Handling
-    missing_str: str = Field(
-        default="__missing__", description="String to represent missing string values"
-    )
-
-    # Logging
-    logging_level: Literal["DEBUG", "INFO", "WARNING", "ERROR", "CRITICAL"] = Field(
-        default="INFO", description="Default logging level"
-    )
-
-    model_config = ConfigDict(validate_assignment=True)
-
-
-# Global configuration instance
-config = CsrLiteConfig()
+# pyre-strict
+"""
+Central configuration for csrlite.
+"""
+
+from typing import Literal, Optional
+
+from pydantic import BaseModel, ConfigDict, Field
+
+
+class CsrLiteConfig(BaseModel):
+    """
+    Global configuration for csrlite library.
+    """
+
+    # Column Name Defaults
+    id_col: str = Field(default="USUBJID", description="Subject Identifier Column")
+    group_col: Optional[str] = Field(default=None, description="Treatment Group Column")
+
+    # Missing Value Handling
+    missing_str: str = Field(
+        default="__missing__", description="String to represent missing string values"
+    )
+
+    # Logging
+    logging_level: Literal["DEBUG", "INFO", "WARNING", "ERROR", "CRITICAL"] = Field(
+        default="INFO", description="Default logging level"
+    )
+
+    model_config = ConfigDict(validate_assignment=True)
+
+
+# Global configuration instance
+config = CsrLiteConfig()