csrlite 0.2.1__py3-none-any.whl → 0.3.0__py3-none-any.whl

csrlite/pd/pd_listing.py

@@ -0,0 +1,461 @@
+# pyre-strict
+"""
+Protocol Deviation (PD) Listing Functions
+
+This module provides functions for generating detailed PD listings showing individual
+protocol deviation records with key details like category, term, and coded term.
+
+The two-step pipeline:
+- pd_listing_ard: Filter, select, sort, and rename columns (returns display-ready data)
+- pd_listing_rtf: Generate formatted RTF output
+- pd_listing: Complete pipeline wrapper
+- study_plan_to_pd_listing: Batch generation from StudyPlan
+
+Uses Polars native SQL capabilities for data manipulation and parse.py utilities
+for StudyPlan parsing.
+"""
+
+from pathlib import Path
+from typing import Any, Dict, List, Optional, Tuple
+
+import polars as pl
+from rtflite import RTFBody, RTFColumnHeader, RTFDocument, RTFFootnote, RTFPage, RTFSource, RTFTitle
+
+from ..common.parse import StudyPlanParser
+from ..common.plan import StudyPlan
+from ..common.utils import apply_common_filters
+
+
+def pd_listing_ard(
+    population: pl.DataFrame,
+    observation: pl.DataFrame,
+    population_filter: Optional[str],
+    observation_filter: Optional[str],
+    id: Tuple[str, str],
+    population_columns: Optional[List[Tuple[str, str]]] = None,
+    observation_columns: Optional[List[Tuple[str, str]]] = None,
+    sort_columns: Optional[List[str]] = None,
+    page_by: Optional[List[str]] = None,
+) -> pl.DataFrame:
+    """
+    Generate Analysis Results Data (ARD) for PD listing.
+
+    Filters and joins population and observation data, then selects relevant columns.
+
+    Args:
+        population: Population DataFrame (subject-level data, e.g., ADSL)
+        observation: Observation DataFrame (event data, e.g., ADPD)
+        population_filter: SQL WHERE clause for population (can be None)
+        observation_filter: SQL WHERE clause for observation (can be None)
+        id: Tuple (variable_name, label) for ID column
+        population_columns: List of tuples (variable_name, label) from population
+                            (e.g., [("SEX", "Sex"), ("RACE", "Race")])
+        observation_columns: List of tuples (variable_name, label) from observation
+                             (e.g., [("DVCAT", "Category")])
+        sort_columns: List of column names to sort by. If None, sorts by id column.
+        page_by: List of column names to page by.
+
+    Returns:
+        pl.DataFrame: Filtered and joined records with selected columns
+    """
+    id_var_name, id_var_label = id
+
+    # Apply common filters
+    # Note: parameter_filter is None for PD as it usually doesn't have a PARAM column like AE
+    population_filtered, observation_to_filter = apply_common_filters(
+        population=population,
+        observation=observation,
+        population_filter=population_filter,
+        observation_filter=observation_filter,
+        parameter_filter=None,
+    )
+
+    assert observation_to_filter is not None
+
+    # Filter observation to include only subjects in filtered population
+    observation_filtered = observation_to_filter.filter(
+        pl.col(id_var_name).is_in(population_filtered[id_var_name].to_list())
+    )
+
+    # Determine which observation columns to select
+    if observation_columns is None:
+        # Default: select id column only
+        obs_cols = [id_var_name]
+    else:
+        # Extract variable names from tuples
+        obs_col_names = [var_name for var_name, _ in observation_columns]
+        # Ensure id is included
+        obs_cols = [id_var_name] + [col for col in obs_col_names if col != id_var_name]
+
+    # Select available observation columns
+    obs_cols_available = [col for col in obs_cols if col in observation_filtered.columns]
+    result = observation_filtered.select(obs_cols_available)
+
+    # Join with population to add population columns
+    if population_columns is not None:
+        # Extract variable names from tuples
+        pop_col_names = [var_name for var_name, _ in population_columns]
+        # Select id + requested population columns
+        pop_cols = [id_var_name] + [col for col in pop_col_names if col != id_var_name]
+        pop_cols_available = [col for col in pop_cols if col in population_filtered.columns]
+        population_subset = population_filtered.select(pop_cols_available)
+
+        # Left join to preserve all observation records
+        result = result.join(population_subset, on=id_var_name, how="left")
+
+    # Create __index__ column for pagination
+    # Default to using the id column as the index
+    if id_var_name in result.columns:
+        result = result.with_columns(
+            (pl.lit(f"{id_var_label} = ") + pl.col(id_var_name).cast(pl.Utf8)).alias("__index__")
+        )
+
+    # Use page_by columns if provided and they exist
+    existing_page_by_cols = [col for col in page_by if col in result.columns] if page_by else []
+
+    if existing_page_by_cols:
+        # Create a mapping from column name to label
+        column_labels = {id_var_name: id_var_label}
+        if population_columns:
+            for var_name, var_label in population_columns:
+                column_labels[var_name] = var_label
+
+        # Ensure the order of labels matches the order of columns in page_by
+        index_expressions = []
+        for col_name in existing_page_by_cols:
+            label = column_labels.get(col_name, col_name)
+            index_expressions.append(pl.lit(f"{label} = ") + pl.col(col_name).cast(pl.Utf8))
+
+        result = result.with_columns(
+            pl.concat_str(index_expressions, separator=", ").alias("__index__")
+        )
+
+        page_by_remove = [col for col in (page_by or []) if col != id_var_name]
+        result = result.drop(page_by_remove)
+
+    if "__index__" in result.columns:
+        # Get all columns except __index__
+        other_columns = [col for col in result.columns if col != "__index__"]
+        # Reorder to have __index__ first
+        result = result.select(["__index__"] + other_columns)
+
+    # Sort by specified columns or default to id column
+    if sort_columns is None:
+        # Default: sort by id column if it exists in result
+        if id_var_name in result.columns:
+            result = result.sort(id_var_name)
+    else:
+        # Sort by specified columns that exist in result
+        cols_to_sort = [col for col in sort_columns if col in result.columns]
+        if cols_to_sort:
+            result = result.sort(cols_to_sort)
+
+    return result
+
+
+def pd_listing_rtf(
+    df: pl.DataFrame,
+    column_labels: Dict[str, str],
+    title: List[str],
+    footnote: Optional[List[str]],
+    source: Optional[List[str]],
+    col_rel_width: Optional[List[float]] = None,
+    group_by: Optional[List[str]] = None,
+    page_by: Optional[List[str]] = None,
+    orientation: str = "landscape",
+) -> RTFDocument:
+    """
+    Generate RTF table from PD listing display DataFrame.
+
+    Creates a formatted RTF table with column headers and optional section grouping/pagination.
+
+    Args:
+        df: Display DataFrame from pd_listing_ard
+        column_labels: Dictionary mapping column names to display labels
+        title: Title(s) for the table as list of strings
+        footnote: Optional footnote(s) as list of strings
+        source: Optional source note(s) as list of strings
+        col_rel_width: Optional list of relative column widths. If None, auto-calculated
+                       as equal widths for all columns
+        group_by: Optional list of column names to group by for section headers within pages.
+                  Should only contain population columns (e.g., ["TRT01A", "USUBJID"])
+        page_by: Optional list of column names to trigger new pages when values change.
+                 Should only contain population columns (e.g., ["TRT01A"])
+        orientation: Page orientation ("portrait" or "landscape"), default is "landscape"
+
+    Returns:
+        RTFDocument: RTF document object that can be written to file
+    """
+    # Calculate number of columns
+    n_cols = len(df.columns)
+
+    # Build column headers using labels
+    col_header = [column_labels.get(col, col) for col in df.columns]
+
+    # Calculate column widths
+    if col_rel_width is None:
+        col_widths = [1.0] * n_cols
+    else:
+        col_widths = col_rel_width
+
+    # Normalize title, footnote, source to lists
+    title_list = title
+    footnote_list: List[str] = footnote or []
+    source_list: List[str] = source or []
+
+    # Build RTF document
+    rtf_components: Dict[str, Any] = {
+        "df": df,
+        "rtf_page": RTFPage(orientation=orientation),
+        "rtf_title": RTFTitle(text=title_list),
+        "rtf_column_header": [
+            RTFColumnHeader(
+                text=col_header[1:],
+                col_rel_width=col_widths[1:],
+                text_justification=["l"] + ["l"] * (n_cols - 1),  # Default left align for PD
+            ),
+        ],
+        "rtf_body": RTFBody(
+            col_rel_width=col_widths,
+            text_justification=["l"] * n_cols,
+            border_left=["single"],
+            border_top=["single"] + [""] * (n_cols - 1),
+            border_bottom=["single"] + [""] * (n_cols - 1),
+            group_by=group_by,
+            page_by=page_by,
+        ),
+    }
+
+    # Add optional footnote
+    if footnote_list:
+        rtf_components["rtf_footnote"] = RTFFootnote(text=footnote_list)
+
+    # Add optional source
+    if source_list:
+        rtf_components["rtf_source"] = RTFSource(text=source_list)
+
+    # Create RTF document
+    doc = RTFDocument(**rtf_components)
+
+    return doc
+
+
+def pd_listing(
+    population: pl.DataFrame,
+    observation: pl.DataFrame,
+    population_filter: Optional[str],
+    observation_filter: Optional[str],
+    id: Tuple[str, str],
+    title: List[str],
+    footnote: Optional[List[str]],
+    source: Optional[List[str]],
+    output_file: str,
+    population_columns: Optional[List[Tuple[str, str]]] = None,
+    observation_columns: Optional[List[Tuple[str, str]]] = None,
+    sort_columns: Optional[List[str]] = None,
+    group_by: Optional[List[str]] = None,
+    page_by: Optional[List[str]] = None,
+    col_rel_width: Optional[List[float]] = None,
+    orientation: str = "landscape",
+) -> str:
+    """
+    Complete PD listing pipeline wrapper.
+
+    This function orchestrates the two-step pipeline:
+    1. pd_listing_ard: Filter, join, select, and sort columns
+    2. pd_listing_rtf: Generate RTF output with optional grouping/pagination
+
+    Args:
+        population: Population DataFrame (subject-level data, e.g., ADSL)
+        observation: Observation DataFrame (event data, e.g., ADPD)
+        population_filter: SQL WHERE clause for population (can be None)
+        observation_filter: SQL WHERE clause for observation (can be None)
+        id: Tuple (variable_name, label) for ID column
+        title: Title for RTF output as list of strings
+        footnote: Optional footnote for RTF output as list of strings
+        source: Optional source for RTF output as list of strings
+        output_file: File path to write RTF output
+        population_columns: Optional list of tuples (variable_name, label) from population
+        observation_columns: Optional list of tuples (variable_name, label) from observation
+        sort_columns: Optional list of column names to sort by. If None, sorts by id column.
+        group_by: Optional list of column names to group by for section headers
+                  (population columns only)
+        page_by: Optional list of column names to trigger new pages (population columns only)
+        col_rel_width: Optional column widths for RTF output
+        orientation: Page orientation ("portrait" or "landscape"), default is "landscape"
+    """
+    # Step 1: Generate ARD (includes filtering, joining, and selecting)
+    df = pd_listing_ard(
+        population=population,
+        observation=observation,
+        population_filter=population_filter,
+        observation_filter=observation_filter,
+        id=id,
+        population_columns=population_columns,
+        observation_columns=observation_columns,
+        sort_columns=sort_columns,
+        page_by=page_by,
+    )
+
+    # Build column labels from tuples
+    id_var_name, id_var_label = id
+    column_labels = {id_var_name: id_var_label}
+
+    # Add observation column labels
+    if observation_columns is not None:
+        for var_name, var_label in observation_columns:
+            column_labels[var_name] = var_label
+
+    # Add population column labels
+    if population_columns is not None:
+        for var_name, var_label in population_columns:
+            column_labels[var_name] = var_label
+
+    # Set __index__ header to empty string
+    column_labels["__index__"] = ""
+
+    # Step 2: Generate RTF and write to file
+    rtf_doc = pd_listing_rtf(
+        df=df,
+        column_labels=column_labels,
+        title=title,
+        footnote=footnote,
+        source=source,
+        col_rel_width=col_rel_width,
+        group_by=group_by,
+        page_by=["__index__"],
+        orientation=orientation,
+    )
+    rtf_doc.write_rtf(output_file)
+
+    return output_file
+
+
+def study_plan_to_pd_listing(
+    study_plan: StudyPlan,
+) -> List[str]:
+    """
+    Generate PD listing RTF outputs for all analyses defined in StudyPlan.
+
+    This function reads the expanded plan from StudyPlan and generates
+    an RTF listing for each pd_listing analysis specification automatically.
+
+    Args:
+        study_plan: StudyPlan object with loaded datasets and analysis specifications
+
+    Returns:
+        List[str]: List of paths to generated RTF files
+    """
+
+    # Meta data
+    analysis = "pd_listing"
+    output_dir = study_plan.output_dir
+    # Adjusted column widths for PD
+    col_rel_width = [1.0, 1.0, 1.0, 3.0, 2.0]
+    footnote = None
+    source = None
+
+    population_df_name = "adsl"
+    observation_df_name = "adpd"
+
+    id = ("USUBJID", "Subject ID")
+    # Column configuration with labels - easy to customize
+    # Population columns (demographics) - group variable will be added dynamically
+    population_columns_base: List[
+        Tuple[str, str]
+    ] = []  # Often empty for PD listing, maybe just ID and treatment
+
+    # Observation columns (event details)
+    # Using the columns identified from adpd.parquet
+    observation_columns_base = [
+        ("DVCAT", "Category"),
+        ("DVTERM", "Term"),
+        ("DVDECOD", "Coded Term"),
+    ]
+
+    # Sorting configuration
+    sort_columns = ["TRT01A", "USUBJID", "DVCAT", "DVTERM"]
+    page_by = ["USUBJID", "TRT01A"]
+    group_by = ["USUBJID"]
+
+    # Create output directory if it doesn't exist
+    Path(output_dir).mkdir(parents=True, exist_ok=True)
+
+    # Initialize parser
+    parser = StudyPlanParser(study_plan)
+
+    # Get expanded plan DataFrame
+    plan_df = study_plan.get_plan_df()
+
+    # Filter for PD listing analyses
+    pd_plans = plan_df.filter(pl.col("analysis") == analysis)
+
+    rtf_files = []
+
+    # Generate RTF for each analysis
+    for row in pd_plans.iter_rows(named=True):
+        population = row["population"]
+        observation = row.get("observation")
+        group = row.get("group")
+
+        # Validate group is specified
+        if group is None:
+            raise ValueError(
+                f"Group not specified in YAML for analysis: population={population}, "
+                f"observation={observation}. "
+                "Please add group to your YAML plan."
+            )
+
+        # Get datasets using parser
+        population_df, observation_df = parser.get_datasets(population_df_name, observation_df_name)
+
+        # Get filters using parser
+        population_filter = parser.get_population_filter(population)
+        obs_filter = parser.get_observation_filter(observation)
+
+        # Get group variable name from YAML
+        group_var_name, group_labels = parser.get_group_info(group)
+
+        # Determine group variable label
+        group_var_label = group_labels[0] if group_labels else "Treatment"
+
+        # Build columns dynamically from base configuration with labels
+        population_columns = population_columns_base + [(group_var_name, group_var_label)]
+        observation_columns = observation_columns_base
+
+        # Build title with population and observation context
+        title_parts = ["Listing of Protocol Deviations"]
+
+        pop_kw = study_plan.keywords.populations.get(population)
+        if pop_kw and pop_kw.label:
+            title_parts.append(pop_kw.label)
+
+        # Build output filename
+        filename = f"{analysis}_{population}"
+        if observation:
+            filename += f"_{observation}"
+        filename += ".rtf"
+        output_file = str(Path(output_dir) / filename)
+
+        # Generate RTF
+        rtf_path = pd_listing(
+            population=population_df,
+            observation=observation_df,
+            population_filter=population_filter,
+            observation_filter=obs_filter,
+            id=id,
+            title=title_parts,
+            footnote=footnote,
+            source=source,
+            output_file=output_file,
+            population_columns=population_columns,
+            observation_columns=observation_columns,
+            sort_columns=sort_columns,
+            col_rel_width=col_rel_width,
+            group_by=group_by,
+            page_by=page_by,
+        )
+
+        rtf_files.append(rtf_path)
+
+    return rtf_files

{csrlite-0.2.1.dist-info → csrlite-0.3.0.dist-info}/METADATA

@@ -1,68 +1,68 @@
-Metadata-Version: 2.4
-Name: csrlite
-Version: 0.2.1
-Summary: A hierarchical YAML-based framework for generating Tables, Listings, and Figures in clinical trials
-Author-email: Clinical Biostatistics Team <biostat@example.com>, Ming-Chun Chen <hellomingchun@gmail.com>
-License: MIT
-Project-URL: Homepage, https://github.com/elong0527/csrlite
-Project-URL: Documentation, https://elong0527.github.io/csrlite
-Project-URL: Repository, https://github.com/elong0527/csrlite.git
-Project-URL: Bug Tracker, https://github.com/elong0527/csrlite/issues
-Keywords: clinical-trials,biostatistics,yaml,tlf,tables,listings,figures
-Classifier: Development Status :: 3 - Alpha
-Classifier: Intended Audience :: Science/Research
-Classifier: License :: OSI Approved :: MIT License
-Classifier: Programming Language :: Python :: 3
-Classifier: Programming Language :: Python :: 3.10
-Classifier: Programming Language :: Python :: 3.11
-Classifier: Topic :: Scientific/Engineering :: Bio-Informatics
-Requires-Python: >=3.10
-Description-Content-Type: text/markdown
-Requires-Dist: pydantic>=2.0.0
-Requires-Dist: pyyaml>=6.0
-Requires-Dist: polars>=0.20.0
-Requires-Dist: rtflite>=2.1.1
-Provides-Extra: rtf
-Requires-Dist: rtflite; extra == "rtf"
-Provides-Extra: plotting
-Requires-Dist: matplotlib>=3.5.0; extra == "plotting"
-Requires-Dist: plotly>=5.0.0; extra == "plotting"
-Provides-Extra: dev
-Requires-Dist: pytest-cov>=4.0.0; extra == "dev"
-Requires-Dist: pytest>=9.0.1; extra == "dev"
-Requires-Dist: black>=22.0.0; extra == "dev"
-Requires-Dist: isort>=7.0.0; extra == "dev"
-Requires-Dist: ruff>=0.14.8; extra == "dev"
-Requires-Dist: mypy>=1.19.0; extra == "dev"
-Requires-Dist: quarto>=0.1.0; extra == "dev"
-Requires-Dist: pyre-check>=0.9.18; extra == "dev"
-Requires-Dist: jupyter>=1.1.1; extra == "dev"
-Requires-Dist: jupyter-cache>=1.0.1; extra == "dev"
-Requires-Dist: nbformat>=5.10.4; extra == "dev"
-Provides-Extra: all
-Requires-Dist: rtflite; extra == "all"
-Requires-Dist: matplotlib>=3.5.0; extra == "all"
-Requires-Dist: plotly>=5.0.0; extra == "all"
-
-# csrlite
-
-[![CI](https://github.com/elong0527/csrlite/actions/workflows/ci.yml/badge.svg)](https://github.com/elong0527/csrlite/actions/workflows/ci.yml)
-[![codecov](https://codecov.io/gh/elong0527/csrlite/branch/main/graph/badge.svg)](https://codecov.io/gh/elong0527/csrlite)
-[![PyPI version](https://badge.fury.io/py/csrlite.svg)](https://badge.fury.io/py/csrlite)
-[![Python 3.10+](https://img.shields.io/badge/python-3.10+-blue.svg)](https://www.python.org/downloads/)
-
-A hierarchical YAML-based framework for generating Tables, Listings, and Figures in clinical trials.
-
-## Installation
-
-```bash
-pip install csrlite
-```
-
-## Documentation
-
-Visit [https://elong0527.github.io/csrlite](https://elong0527.github.io/csrlite) for full documentation.
-
-## License
-
-MIT License - see [LICENSE](LICENSE) file for details.
+Metadata-Version: 2.4
+Name: csrlite
+Version: 0.3.0
+Summary: A hierarchical YAML-based framework for generating Tables, Listings, and Figures in clinical trials
+Author-email: Yilong Zhang <elong0527@gmail.com>, Ming-Chun Chen <hellomingchun@gmail.com>
+License: MIT
+Project-URL: Homepage, https://github.com/elong0527/csrlite
+Project-URL: Documentation, https://elong0527.github.io/csrlite
+Project-URL: Repository, https://github.com/elong0527/csrlite.git
+Project-URL: Bug Tracker, https://github.com/elong0527/csrlite/issues
+Keywords: clinical-trials,biostatistics,yaml,tlf,tables,listings,figures
+Classifier: Development Status :: 3 - Alpha
+Classifier: Intended Audience :: Science/Research
+Classifier: License :: OSI Approved :: MIT License
+Classifier: Programming Language :: Python :: 3
+Classifier: Programming Language :: Python :: 3.10
+Classifier: Programming Language :: Python :: 3.11
+Classifier: Topic :: Scientific/Engineering :: Bio-Informatics
+Requires-Python: >=3.10
+Description-Content-Type: text/markdown
+Requires-Dist: pydantic>=2.0.0
+Requires-Dist: pyyaml>=6.0
+Requires-Dist: polars>=0.20.0
+Requires-Dist: rtflite>=2.1.1
+Provides-Extra: rtf
+Requires-Dist: rtflite; extra == "rtf"
+Provides-Extra: plotting
+Requires-Dist: matplotlib>=3.5.0; extra == "plotting"
+Requires-Dist: plotly>=5.0.0; extra == "plotting"
+Provides-Extra: dev
+Requires-Dist: pytest-cov>=4.0.0; extra == "dev"
+Requires-Dist: pytest>=9.0.1; extra == "dev"
+Requires-Dist: black>=22.0.0; extra == "dev"
+Requires-Dist: isort>=7.0.0; extra == "dev"
+Requires-Dist: ruff>=0.14.8; extra == "dev"
+Requires-Dist: mypy>=1.19.0; extra == "dev"
+Requires-Dist: quarto>=0.1.0; extra == "dev"
+Requires-Dist: pyre-check>=0.9.18; extra == "dev"
+Requires-Dist: jupyter>=1.1.1; extra == "dev"
+Requires-Dist: jupyter-cache>=1.0.1; extra == "dev"
+Requires-Dist: nbformat>=5.10.4; extra == "dev"
+Provides-Extra: all
+Requires-Dist: rtflite; extra == "all"
+Requires-Dist: matplotlib>=3.5.0; extra == "all"
+Requires-Dist: plotly>=5.0.0; extra == "all"
+
+# csrlite
+
+[![CI](https://github.com/elong0527/csrlite/actions/workflows/ci.yml/badge.svg)](https://github.com/elong0527/csrlite/actions/workflows/ci.yml)
+[![codecov](https://codecov.io/gh/elong0527/csrlite/branch/main/graph/badge.svg)](https://codecov.io/gh/elong0527/csrlite)
+[![PyPI version](https://badge.fury.io/py/csrlite.svg)](https://badge.fury.io/py/csrlite)
+[![Python 3.10+](https://img.shields.io/badge/python-3.10+-blue.svg)](https://www.python.org/downloads/)
+
+A hierarchical YAML-based framework for generating Tables, Listings, and Figures in clinical trials.
+
+## Installation
+
+```bash
+pip install csrlite
+```
+
+## Documentation
+
+Visit [https://elong0527.github.io/csrlite](https://elong0527.github.io/csrlite) for full documentation.
+
+## License
+
+MIT License - see [LICENSE](LICENSE) file for details.

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