csrlite 0.2.1__py3-none-any.whl → 0.3.0__py3-none-any.whl

csrlite/disposition/disposition.py

@@ -1,332 +1,332 @@
-# pyre-strict
-"""
-Disposition Table 1.1 Analysis Functions
-
-This module provides a pipeline for Disposition Table 1.1 summary analysis:
-- disposition_ard: Generate Analysis Results Data (ARD)
-- disposition_df: Transform ARD to display format
-- disposition_rtf: Generate formatted RTF output
-- disposition: Complete pipeline wrapper
-- study_plan_to_disposition_summary: Batch generation from StudyPlan
-"""
-
-from pathlib import Path
-
-import polars as pl
-from rtflite import RTFDocument
-
-from ..common.count import count_subject, count_subject_with_observation
-from ..common.parse import StudyPlanParser
-from ..common.plan import StudyPlan
-from ..common.rtf import create_rtf_table_n_pct
-from ..common.utils import apply_common_filters
-
-
-def study_plan_to_disposition_summary(
-    study_plan: StudyPlan,
-) -> list[str]:
-    """
-    Generate Disposition Summary Table outputs for all analyses defined in StudyPlan.
-    """
-    # Meta data
-    analysis_type = "disposition_summary"
-    output_dir = study_plan.output_dir
-    title = "Disposition of Participants"
-    footnote = ["Percentages are based on the number of enrolled participants."]
-    source = None
-
-    population_df_name = "adsl"
-
-    id = ("USUBJID", "Subject ID")
-    ds_term = ("EOSSTT", "Disposition Status")
-    dist_reason_term = ("DCSREAS", "Discontinued Reason")
-
-    total = True
-    missing_group = "error"
-
-    # Create output directory
-    Path(output_dir).mkdir(parents=True, exist_ok=True)
-
-    # Initialize parser
-    parser = StudyPlanParser(study_plan)
-
-    # Get expanded plan DataFrame
-    plan_df = study_plan.get_plan_df()
-
-    # Filter for disposition analyses
-    disp_plans = plan_df.filter(pl.col("analysis") == analysis_type)
-
-    rtf_files = []
-
-    for row in disp_plans.iter_rows(named=True):
-        population = row["population"]
-        group = row.get("group")
-        title_text = title
-
-        # Get datasets
-        (population_df,) = parser.get_datasets(population_df_name)
-
-        # Get filters
-        population_filter = parser.get_population_filter(population)
-
-        # Get group info (optional)
-        if group is not None:
-            group_var_name, group_labels = parser.get_group_info(group)
-            group_var_label = group_labels[0] if group_labels else group_var_name
-            group_tuple = (group_var_name, group_var_label)
-        else:
-            # When no group specified, use a dummy group column for overall counts
-            group_tuple = None
-
-        # Build title
-        title_parts = [title_text]
-        pop_kw = study_plan.keywords.populations.get(population)
-        if pop_kw and pop_kw.label:
-            title_parts.append(pop_kw.label)
-
-        # Build output filename
-        group_suffix = f"_{group}" if group else ""
-        filename = f"{analysis_type}_{population}{group_suffix}.rtf"
-        output_file = str(Path(output_dir) / filename)
-
-        rtf_path = disposition(
-            population=population_df,
-            population_filter=population_filter,
-            id=id,
-            group=group_tuple,
-            ds_term=ds_term,
-            dist_reason_term=dist_reason_term,
-            title=title_parts,
-            footnote=footnote,
-            source=source,
-            output_file=output_file,
-            total=total,
-            missing_group=missing_group,
-        )
-        rtf_files.append(rtf_path)
-
-    return rtf_files
-
-
-def disposition(
-    population: pl.DataFrame,
-    population_filter: str | None,
-    id: tuple[str, str],
-    group: tuple[str, str] | None,
-    ds_term: tuple[str, str],
-    dist_reason_term: tuple[str, str],
-    title: list[str],
-    footnote: list[str] | None,
-    source: list[str] | None,
-    output_file: str,
-    total: bool = True,
-    col_rel_width: list[float] | None = None,
-    missing_group: str = "error",
-) -> str:
-    """
-    Complete Disposition Summary Table pipeline wrapper.
-    """
-    # Step 1: Generate ARD
-    ard = disposition_ard(
-        population=population,
-        population_filter=population_filter,
-        id=id,
-        group=group,
-        ds_term=ds_term,
-        dist_reason_term=dist_reason_term,
-        total=total,
-        missing_group=missing_group,
-    )
-
-    # Step 2: Transform to display format
-    df = disposition_df(ard)
-
-    # Step 3: Generate RTF
-    rtf_doc = disposition_rtf(
-        df=df,
-        title=title,
-        footnote=footnote,
-        source=source,
-        col_rel_width=col_rel_width,
-    )
-    rtf_doc.write_rtf(output_file)
-
-    return output_file
-
-
-def _validate_disposition_data(df: pl.DataFrame, ds_var: str, reason_var: str) -> None:
-    """
-    Validate disposition data integrity.
-
-    Rules:
-    1. ds_var must be {Completed, Ongoing, Discontinued} and non-null.
-    2. If ds_var is Completed/Ongoing, reason_var must be the same as ds_var or null.
-    3. If ds_var is Discontinued, reason_var must be non-null and not Completed/Ongoing.
-    """
-    # Rule 1: Valid Statuses
-    valid_statuses = ["Completed", "Ongoing", "Discontinued"]
-    if df[ds_var].is_null().any():
-        raise ValueError(f"Found null values in disposition status column '{ds_var}'")
-
-    invalid_status = df.filter(~pl.col(ds_var).is_in(valid_statuses))
-    if not invalid_status.is_empty():
-        bad_values = invalid_status[ds_var].unique().to_list()
-        raise ValueError(
-            f"Invalid disposition statuses found: {bad_values}. Must be one of {valid_statuses}"
-        )
-
-    # Rule 2: Completed/Ongoing implies Reason is Null OR equal to Status
-    inconsistent_completed = df.filter(
-        (pl.col(ds_var).is_in(["Completed", "Ongoing"]))
-        & (~pl.col(reason_var).is_null())
-        & (pl.col(reason_var) != pl.col(ds_var))
-    )
-    if not inconsistent_completed.is_empty():
-        raise ValueError(
-            f"Found subjects with status 'Completed' or 'Ongoing' with mismatched "
-            f"discontinuation reason in '{reason_var}'. Reason must be Null or match Status."
-        )
-
-    # Rule 3: Discontinued implies Reason is NOT Null AND NOT {Completed, Ongoing}
-    invalid_discontinued = df.filter(
-        (pl.col(ds_var) == "Discontinued")
-        & ((pl.col(reason_var).is_null()) | (pl.col(reason_var).is_in(["Completed", "Ongoing"])))
-    )
-    if not invalid_discontinued.is_empty():
-        raise ValueError(
-            f"Found subjects with status 'Discontinued' but missing or invalid "
-            f"discontinuation reason in '{reason_var}'"
-        )
-
-
-def disposition_ard(
-    population: pl.DataFrame,
-    population_filter: str | None,
-    id: tuple[str, str],
-    group: tuple[str, str] | None,
-    ds_term: tuple[str, str],
-    dist_reason_term: tuple[str, str],
-    total: bool,
-    missing_group: str,
-    pop_var_name: str = "Enrolled",
-) -> pl.DataFrame:
-    """
-    Generate ARD for Summary Table.
-    """
-    # Unpack variables
-    ds_var_name, _ = ds_term
-    dist_reason_var_name, _ = dist_reason_term
-    id_var_name, _ = id
-
-    # Validate Data
-    _validate_disposition_data(population, ds_var_name, dist_reason_var_name)
-
-    # Apply common filters
-    population_filtered, _ = apply_common_filters(
-        population=population,
-        observation=None,
-        population_filter=population_filter,
-        observation_filter=None,
-    )
-
-    if group:
-        group_var_name, _ = group
-    else:
-        # Create dummy group for overall analysis
-        group_var_name = "Overall"
-        total = False
-        population_filtered = population_filtered.with_columns(
-            pl.lit("Overall").alias(group_var_name)
-        )
-
-    # Enrolled Subjects
-    n_pop_counts = count_subject(
-        population=population_filtered,
-        id=id_var_name,
-        group=group_var_name,
-        total=total,
-        missing_group=missing_group,
-    )
-
-    n_pop = n_pop_counts.select(
-        pl.lit(pop_var_name).alias("__index__"),
-        pl.col(group_var_name).cast(pl.String).alias("__group__"),
-        pl.col("n_subj_pop").cast(pl.String).alias("__value__"),
-    )
-
-    # Hierarchical Counts for Status and Reason
-    # Level 1: Status (Completed, Ongoing, Discontinued)
-    # Level 2: Status + Reason (Only relevant for Discontinued)
-    n_dict = count_subject_with_observation(
-        population=population_filtered,
-        observation=population_filtered,
-        id=id_var_name,
-        group=group_var_name,
-        variable=[ds_var_name, dist_reason_var_name],
-        total=total,
-        missing_group=missing_group,
-    )
-
-    # Filter and format
-    # Identify rows:
-    # 1. Status rows: Where reason is "__all__"
-    # 2. Reason rows: Where reason is specific value (indented)
-    n_dict = n_dict.unique([group_var_name, ds_var_name, dist_reason_var_name, "__id__"])
-
-    # Filter out redundant nested rows (e.g., "Completed" under "Completed")
-    n_dict = n_dict.filter(pl.col(dist_reason_var_name) != pl.col(ds_var_name))
-
-    n_final = n_dict.sort("__id__").select(
-        pl.col("__variable__").alias("__index__"),
-        pl.col(group_var_name).cast(pl.String).alias("__group__"),
-        pl.col("n_pct_subj_fmt").cast(pl.String).alias("__value__"),
-    )
-
-    return pl.concat([n_pop, n_final])
-
-
-def disposition_df(ard: pl.DataFrame) -> pl.DataFrame:
-    """
-    Transform ARD to display format.
-    """
-    # Pivot
-    # Pivot from long to wide format
-    df_wide = ard.pivot(index="__index__", on="__group__", values="__value__")
-
-    # Rename __index__ to display column name
-    df_wide = df_wide.rename({"__index__": "Term"}).select(pl.col("Term"), pl.exclude("Term"))
-
-    return df_wide
-
-
-def disposition_rtf(
-    df: pl.DataFrame,
-    title: list[str],
-    footnote: list[str] | None,
-    source: list[str] | None,
-    col_rel_width: list[float] | None = None,
-) -> RTFDocument:
-    """
-    Generate RTF.
-    """
-    # Reuse generic table creation
-    # Columns: Disposition Status, Group 1, Group 2, ... Total
-
-    n_cols = len(df.columns)
-    col_header_1 = [""] + list(df.columns[1:])
-    col_header_2 = [""] + ["n (%)"] * (n_cols - 1)
-
-    if col_rel_width is None:
-        col_widths = [2.5] + [1] * (n_cols - 1)
-    else:
-        col_widths = col_rel_width
-
-    return create_rtf_table_n_pct(
-        df=df,
-        col_header_1=col_header_1,
-        col_header_2=col_header_2,
-        col_widths=col_widths,
-        title=title,
-        footnote=footnote,
-        source=source,
-    )
+# pyre-strict
+"""
+Disposition Table 1.1 Analysis Functions
+
+This module provides a pipeline for Disposition Table 1.1 summary analysis:
+- disposition_ard: Generate Analysis Results Data (ARD)
+- disposition_df: Transform ARD to display format
+- disposition_rtf: Generate formatted RTF output
+- disposition: Complete pipeline wrapper
+- study_plan_to_disposition_summary: Batch generation from StudyPlan
+"""
+
+from pathlib import Path
+
+import polars as pl
+from rtflite import RTFDocument
+
+from ..common.count import count_subject, count_subject_with_observation
+from ..common.parse import StudyPlanParser
+from ..common.plan import StudyPlan
+from ..common.rtf import create_rtf_table_n_pct
+from ..common.utils import apply_common_filters
+
+
+def study_plan_to_disposition_summary(
+    study_plan: StudyPlan,
+) -> list[str]:
+    """
+    Generate Disposition Summary Table outputs for all analyses defined in StudyPlan.
+    """
+    # Meta data
+    analysis_type = "disposition_summary"
+    output_dir = study_plan.output_dir
+    title = "Disposition of Participants"
+    footnote = ["Percentages are based on the number of enrolled participants."]
+    source = None
+
+    population_df_name = "adsl"
+
+    id = ("USUBJID", "Subject ID")
+    ds_term = ("EOSSTT", "Disposition Status")
+    dist_reason_term = ("DCSREAS", "Discontinued Reason")
+
+    total = True
+    missing_group = "error"
+
+    # Create output directory
+    Path(output_dir).mkdir(parents=True, exist_ok=True)
+
+    # Initialize parser
+    parser = StudyPlanParser(study_plan)
+
+    # Get expanded plan DataFrame
+    plan_df = study_plan.get_plan_df()
+
+    # Filter for disposition analyses
+    disp_plans = plan_df.filter(pl.col("analysis") == analysis_type)
+
+    rtf_files = []
+
+    for row in disp_plans.iter_rows(named=True):
+        population = row["population"]
+        group = row.get("group")
+        title_text = title
+
+        # Get datasets
+        (population_df,) = parser.get_datasets(population_df_name)
+
+        # Get filters
+        population_filter = parser.get_population_filter(population)
+
+        # Get group info (optional)
+        if group is not None:
+            group_var_name, group_labels = parser.get_group_info(group)
+            group_var_label = group_labels[0] if group_labels else group_var_name
+            group_tuple = (group_var_name, group_var_label)
+        else:
+            # When no group specified, use a dummy group column for overall counts
+            group_tuple = None
+
+        # Build title
+        title_parts = [title_text]
+        pop_kw = study_plan.keywords.populations.get(population)
+        if pop_kw and pop_kw.label:
+            title_parts.append(pop_kw.label)
+
+        # Build output filename
+        group_suffix = f"_{group}" if group else ""
+        filename = f"{analysis_type}_{population}{group_suffix}.rtf"
+        output_file = str(Path(output_dir) / filename)
+
+        rtf_path = disposition(
+            population=population_df,
+            population_filter=population_filter,
+            id=id,
+            group=group_tuple,
+            ds_term=ds_term,
+            dist_reason_term=dist_reason_term,
+            title=title_parts,
+            footnote=footnote,
+            source=source,
+            output_file=output_file,
+            total=total,
+            missing_group=missing_group,
+        )
+        rtf_files.append(rtf_path)
+
+    return rtf_files
+
+
+def disposition(
+    population: pl.DataFrame,
+    population_filter: str | None,
+    id: tuple[str, str],
+    group: tuple[str, str] | None,
+    ds_term: tuple[str, str],
+    dist_reason_term: tuple[str, str],
+    title: list[str],
+    footnote: list[str] | None,
+    source: list[str] | None,
+    output_file: str,
+    total: bool = True,
+    col_rel_width: list[float] | None = None,
+    missing_group: str = "error",
+) -> str:
+    """
+    Complete Disposition Summary Table pipeline wrapper.
+    """
+    # Step 1: Generate ARD
+    ard = disposition_ard(
+        population=population,
+        population_filter=population_filter,
+        id=id,
+        group=group,
+        ds_term=ds_term,
+        dist_reason_term=dist_reason_term,
+        total=total,
+        missing_group=missing_group,
+    )
+
+    # Step 2: Transform to display format
+    df = disposition_df(ard)
+
+    # Step 3: Generate RTF
+    rtf_doc = disposition_rtf(
+        df=df,
+        title=title,
+        footnote=footnote,
+        source=source,
+        col_rel_width=col_rel_width,
+    )
+    rtf_doc.write_rtf(output_file)
+
+    return output_file
+
+
+def _validate_disposition_data(df: pl.DataFrame, ds_var: str, reason_var: str) -> None:
+    """
+    Validate disposition data integrity.
+
+    Rules:
+    1. ds_var must be {Completed, Ongoing, Discontinued} and non-null.
+    2. If ds_var is Completed/Ongoing, reason_var must be the same as ds_var or null.
+    3. If ds_var is Discontinued, reason_var must be non-null and not Completed/Ongoing.
+    """
+    # Rule 1: Valid Statuses
+    valid_statuses = ["Completed", "Ongoing", "Discontinued"]
+    if df[ds_var].is_null().any():
+        raise ValueError(f"Found null values in disposition status column '{ds_var}'")
+
+    invalid_status = df.filter(~pl.col(ds_var).is_in(valid_statuses))
+    if not invalid_status.is_empty():
+        bad_values = invalid_status[ds_var].unique().to_list()
+        raise ValueError(
+            f"Invalid disposition statuses found: {bad_values}. Must be one of {valid_statuses}"
+        )
+
+    # Rule 2: Completed/Ongoing implies Reason is Null OR equal to Status
+    inconsistent_completed = df.filter(
+        (pl.col(ds_var).is_in(["Completed", "Ongoing"]))
+        & (~pl.col(reason_var).is_null())
+        & (pl.col(reason_var) != pl.col(ds_var))
+    )
+    if not inconsistent_completed.is_empty():
+        raise ValueError(
+            f"Found subjects with status 'Completed' or 'Ongoing' with mismatched "
+            f"discontinuation reason in '{reason_var}'. Reason must be Null or match Status."
+        )
+
+    # Rule 3: Discontinued implies Reason is NOT Null AND NOT {Completed, Ongoing}
+    invalid_discontinued = df.filter(
+        (pl.col(ds_var) == "Discontinued")
+        & ((pl.col(reason_var).is_null()) | (pl.col(reason_var).is_in(["Completed", "Ongoing"])))
+    )
+    if not invalid_discontinued.is_empty():
+        raise ValueError(
+            f"Found subjects with status 'Discontinued' but missing or invalid "
+            f"discontinuation reason in '{reason_var}'"
+        )
+
+
+def disposition_ard(
+    population: pl.DataFrame,
+    population_filter: str | None,
+    id: tuple[str, str],
+    group: tuple[str, str] | None,
+    ds_term: tuple[str, str],
+    dist_reason_term: tuple[str, str],
+    total: bool,
+    missing_group: str,
+    pop_var_name: str = "Enrolled",
+) -> pl.DataFrame:
+    """
+    Generate ARD for Summary Table.
+    """
+    # Unpack variables
+    ds_var_name, _ = ds_term
+    dist_reason_var_name, _ = dist_reason_term
+    id_var_name, _ = id
+
+    # Validate Data
+    _validate_disposition_data(population, ds_var_name, dist_reason_var_name)
+
+    # Apply common filters
+    population_filtered, _ = apply_common_filters(
+        population=population,
+        observation=None,
+        population_filter=population_filter,
+        observation_filter=None,
+    )
+
+    if group:
+        group_var_name, _ = group
+    else:
+        # Create dummy group for overall analysis
+        group_var_name = "Overall"
+        total = False
+        population_filtered = population_filtered.with_columns(
+            pl.lit("Overall").alias(group_var_name)
+        )
+
+    # Enrolled Subjects
+    n_pop_counts = count_subject(
+        population=population_filtered,
+        id=id_var_name,
+        group=group_var_name,
+        total=total,
+        missing_group=missing_group,
+    )
+
+    n_pop = n_pop_counts.select(
+        pl.lit(pop_var_name).alias("__index__"),
+        pl.col(group_var_name).cast(pl.String).alias("__group__"),
+        pl.col("n_subj_pop").cast(pl.String).alias("__value__"),
+    )
+
+    # Hierarchical Counts for Status and Reason
+    # Level 1: Status (Completed, Ongoing, Discontinued)
+    # Level 2: Status + Reason (Only relevant for Discontinued)
+    n_dict = count_subject_with_observation(
+        population=population_filtered,
+        observation=population_filtered,
+        id=id_var_name,
+        group=group_var_name,
+        variable=[ds_var_name, dist_reason_var_name],
+        total=total,
+        missing_group=missing_group,
+    )
+
+    # Filter and format
+    # Identify rows:
+    # 1. Status rows: Where reason is "__all__"
+    # 2. Reason rows: Where reason is specific value (indented)
+    n_dict = n_dict.unique([group_var_name, ds_var_name, dist_reason_var_name, "__id__"])
+
+    # Filter out redundant nested rows (e.g., "Completed" under "Completed")
+    n_dict = n_dict.filter(pl.col(dist_reason_var_name) != pl.col(ds_var_name))
+
+    n_final = n_dict.sort("__id__").select(
+        pl.col("__variable__").alias("__index__"),
+        pl.col(group_var_name).cast(pl.String).alias("__group__"),
+        pl.col("n_pct_subj_fmt").cast(pl.String).alias("__value__"),
+    )
+
+    return pl.concat([n_pop, n_final])
+
+
+def disposition_df(ard: pl.DataFrame) -> pl.DataFrame:
+    """
+    Transform ARD to display format.
+    """
+    # Pivot
+    # Pivot from long to wide format
+    df_wide = ard.pivot(index="__index__", on="__group__", values="__value__")
+
+    # Rename __index__ to display column name
+    df_wide = df_wide.rename({"__index__": "Term"}).select(pl.col("Term"), pl.exclude("Term"))
+
+    return df_wide
+
+
+def disposition_rtf(
+    df: pl.DataFrame,
+    title: list[str],
+    footnote: list[str] | None,
+    source: list[str] | None,
+    col_rel_width: list[float] | None = None,
+) -> RTFDocument:
+    """
+    Generate RTF.
+    """
+    # Reuse generic table creation
+    # Columns: Disposition Status, Group 1, Group 2, ... Total
+
+    n_cols = len(df.columns)
+    col_header_1 = [""] + list(df.columns[1:])
+    col_header_2 = [""] + ["n (%)"] * (n_cols - 1)
+
+    if col_rel_width is None:
+        col_widths = [2.5] + [1] * (n_cols - 1)
+    else:
+        col_widths = col_rel_width
+
+    return create_rtf_table_n_pct(
+        df=df,
+        col_header_1=col_header_1,
+        col_header_2=col_header_2,
+        col_widths=col_widths,
+        title=title,
+        footnote=footnote,
+        source=source,
+    )