grnsight 6.0.4 → 7.1.1

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (1245) hide show
  1. package/.eslintrc.yml +4 -4
  2. package/database/README.md +224 -79
  3. package/database/constants.py +42 -0
  4. package/database/expression-database/README.md +2 -2
  5. package/database/expression-database/schema.sql +14 -14
  6. package/database/expression-database/scripts/loader.py +6 -6
  7. package/database/filter_update.py +168 -0
  8. package/database/grnsettings-database/README.md +52 -0
  9. package/database/grnsettings-database/schema.sql +4 -0
  10. package/database/loader.py +30 -0
  11. package/database/loader_update.py +36 -0
  12. package/database/network-database/README.md +36 -4
  13. package/database/network-database/schema.sql +7 -7
  14. package/database/network-database/scripts/generate_network.py +16 -24
  15. package/database/network-database/scripts/generate_new_network_version.py +216 -0
  16. package/database/protein-protein-database/README.md +71 -0
  17. package/database/protein-protein-database/schema.sql +37 -0
  18. package/database/protein-protein-database/scripts/generate_protein_network.py +227 -0
  19. package/database/protein-protein-database/scripts/remove_duplicates.sh +4 -0
  20. package/database/utils.py +418 -0
  21. package/package.json +2 -2
  22. package/server/app.js +2 -0
  23. package/server/config/config.js +4 -4
  24. package/server/controllers/additional-sheet-parser.js +2 -1
  25. package/server/controllers/constants.js +5 -0
  26. package/server/controllers/custom-workbook-controller.js +8 -6
  27. package/server/controllers/demo-workbooks.js +1460 -4
  28. package/server/controllers/export-constants.js +3 -2
  29. package/server/controllers/exporters/sif.js +6 -1
  30. package/server/controllers/exporters/xlsx.js +8 -3
  31. package/server/controllers/expression-sheet-parser.js +0 -6
  32. package/server/controllers/grnsettings-database-controller.js +17 -0
  33. package/server/controllers/importers/sif.js +29 -11
  34. package/server/controllers/network-database-controller.js +2 -2
  35. package/server/controllers/network-sheet-parser.js +54 -12
  36. package/server/controllers/protein-database-controller.js +18 -0
  37. package/server/controllers/sif-constants.js +4 -4
  38. package/server/controllers/spreadsheet-controller.js +44 -1
  39. package/server/controllers/workbook-constants.js +21 -4
  40. package/server/dals/expression-dal.js +8 -7
  41. package/server/dals/grnsetting-dal.js +49 -0
  42. package/server/dals/network-dal.js +13 -12
  43. package/server/dals/protein-dal.js +106 -0
  44. package/test/export-tests.js +136 -9
  45. package/test/import-sif-tests.js +54 -13
  46. package/test/test.js +1 -1
  47. package/test-files/additional-sheet-test-files/optimization-parameters-default.xlsx +0 -0
  48. package/test-files/demo-files/18_proteins_81_edges_PPI.xlsx +0 -0
  49. package/test-files/expression-data-test-sheets/expression_sheet_missing_data_ok_export_exact.xlsx +0 -0
  50. package/web-client/config/config.js +4 -4
  51. package/web-client/public/js/api/grnsight-api.js +72 -56
  52. package/web-client/public/js/constants.js +26 -12
  53. package/web-client/public/js/generateNetwork.js +173 -67
  54. package/web-client/public/js/graph.js +420 -150
  55. package/web-client/public/js/grnsight.js +25 -4
  56. package/web-client/public/js/grnstate.js +3 -1
  57. package/web-client/public/js/iframe-coordination.js +3 -3
  58. package/web-client/public/js/setup-handlers.js +28 -32
  59. package/web-client/public/js/setup-load-and-import-handlers.js +196 -170
  60. package/web-client/public/js/update-app.js +84 -17
  61. package/web-client/public/js/upload.js +193 -157
  62. package/web-client/public/lib/bootstrap.file-input/bootstrap.file-input.js +0 -1
  63. package/web-client/public/stylesheets/grnsight.styl +40 -16
  64. package/web-client/views/components/demo.pug +7 -5
  65. package/web-client/views/upload.pug +63 -49
  66. package/.bundle/config +0 -3
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  68. package/Gemfile.lock +0 -259
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  1225. package/gdb/pg_hba.conf +0 -98
  1226. package/gdb/pg_ident.conf +0 -42
  1227. package/gdb/pg_logical/replorigin_checkpoint +0 -0
  1228. package/gdb/pg_multixact/members/0000 +0 -0
  1229. package/gdb/pg_multixact/offsets/0000 +0 -0
  1230. package/gdb/pg_stat/db_0.stat +0 -0
  1231. package/gdb/pg_stat/db_14034.stat +0 -0
  1232. package/gdb/pg_stat/global.stat +0 -0
  1233. package/gdb/pg_subtrans/0000 +0 -0
  1234. package/gdb/pg_wal/000000010000000000000001 +0 -0
  1235. package/gdb/pg_xact/0000 +0 -0
  1236. package/gdb/postgresql.auto.conf +0 -2
  1237. package/gdb/postgresql.conf +0 -796
  1238. package/gdb/postmaster.opts +0 -1
  1239. package/server/API Project-7d45e9f24a96.p12 +0 -0
  1240. package/server/grnmap.pem +0 -31
  1241. package/server/grnsight.pem +0 -19
  1242. package/test-files/import-samples/attributes.graphml +0 -40
  1243. package/test-files/import-samples/port.graphml +0 -32
  1244. package/test-files/import-samples/simple.graphml +0 -31
  1245. package/web-client/public/js/grnsight.min.js +0 -2371
@@ -11,6 +11,7 @@ import {
11
11
  ZOOM_DISPLAY_MAXIMUM_VALUE,
12
12
  ZOOM_DISPLAY_MIDDLE,
13
13
  ZOOM_ADAPTIVE_MAX_SCALE,
14
+ NETWORK_GRN_MODE
14
15
  } from "./constants";
15
16
 
16
17
  /* globals d3 */
@@ -33,6 +34,7 @@ import {
33
34
  * Resize detection logic: to avoid "listener leaks," this is set up a single time here, with an assignable
34
35
  * updateFunction being set when needed.
35
36
  */
37
+
36
38
  let mutationCallback = null;
37
39
  const resizeObserver = new MutationObserver((mutationsList, observer) => {
38
40
  if (typeof(mutationCallback) === "function") {
@@ -50,6 +52,7 @@ export var updaters = {
50
52
  export var drawGraph = function (workbook) {
51
53
  /* eslint-enable no-unused-vars */
52
54
  var $container = $(".grnsight-container");
55
+ var CURSOR_CLASSES = "cursorGrab cursorGrabbing";
53
56
  d3.selectAll("svg").remove();
54
57
 
55
58
  $container.removeClass(CURSOR_CLASSES).addClass("cursorGrab"); // allow graph dragging right away
@@ -61,8 +64,6 @@ export var drawGraph = function (workbook) {
61
64
 
62
65
  var dashedLine = $("#dashedGrayLineButton").prop("checked");
63
66
 
64
- var CURSOR_CLASSES = "cursorGrab cursorGrabbing";
65
-
66
67
  $("#warningMessage").html(workbook.warnings.length !== 0 ? "Click here in order to view warnings." : "");
67
68
 
68
69
  var getNodeWidth = function (node) {
@@ -159,35 +160,40 @@ export var drawGraph = function (workbook) {
159
160
 
160
161
  var zoomDragPrevX = 0;
161
162
  var zoomDragPrevY = 0;
163
+ let graphZoom = 0;
164
+
162
165
  var zoomDragStarted = function () {
163
166
  zoomDragPrevX = d3.event.x;
164
167
  zoomDragPrevY = d3.event.y;
165
168
  $container.removeClass(CURSOR_CLASSES).addClass("cursorGrabbing");
166
- if (!adaptive) {
167
- $container.removeClass(CURSOR_CLASSES);
168
- }
169
169
  };
170
170
 
171
171
  var zoomDragged = function () {
172
- if (adaptive) {
173
- var scale = 1;
174
- if (zoomContainer.attr("transform")) {
175
- var string = zoomContainer.attr("transform");
176
- scale = 1 / +(string.match(/scale\(([^\)]+)\)/)[1]);
177
- }
178
- zoom.translateBy(zoomContainer, scale * (d3.event.x - zoomDragPrevX), scale * (d3.event.y - zoomDragPrevY));
179
- zoomDragPrevX = d3.event.x;
180
- zoomDragPrevY = d3.event.y;
172
+ var scale = 1;
173
+ if (zoomContainer.attr("transform")) {
174
+ var string = zoomContainer.attr("transform");
175
+ scale = 1 / +(string.match(/scale\(([^\)]+)\)/)[1]);
181
176
  }
177
+
178
+ if (adaptive || (!adaptive &&
179
+ flexZoomInBounds(graphZoom) &&
180
+ viewportBoundsMoveDrag(graphZoom, d3.event.dx, d3.event.dy))
181
+ ) {
182
+ zoom.translateBy(
183
+ zoomContainer,
184
+ scale * (d3.event.x - zoomDragPrevX),
185
+ scale * (d3.event.y - zoomDragPrevY)
186
+ );
187
+ }
188
+ zoomDragPrevX = d3.event.x;
189
+ zoomDragPrevY = d3.event.y;
182
190
  };
183
191
 
184
192
  var zoomDragEnded = function () {
185
193
  $container.removeClass(CURSOR_CLASSES).addClass("cursorGrab");
186
- if (!adaptive) {
187
- $container.removeClass(CURSOR_CLASSES);
188
- }
189
194
  };
190
195
 
196
+ // zoomDrag and all functions that it calls handles cursor dragging
191
197
  var zoomDrag = d3.drag()
192
198
  .on("start", zoomDragStarted)
193
199
  .on("drag", zoomDragged)
@@ -207,6 +213,21 @@ export var drawGraph = function (workbook) {
207
213
 
208
214
  var boundingBoxContainer = zoomContainer.append("g"); // appended another g here...
209
215
 
216
+ // This rectangle catches all of the mousewheel and pan events, without letting
217
+ // them bubble up to the body.
218
+ var boundingBoxRect = boundingBoxContainer.append("rect")
219
+ .attr("width", width)
220
+ .attr("height", height)
221
+ .style("fill", "none")
222
+ .style("pointer-events", "all")
223
+ .attr("stroke", "none" )
224
+ .attr("id", "boundingBoxRect");
225
+
226
+ var flexibleContainerRect = boundingBoxContainer.append("rect")
227
+ .attr("class", "boundingBox")
228
+ .attr("fill", "none")
229
+ .attr("id", "flexibleContainerRect");
230
+
210
231
  var zoom = d3.zoom()
211
232
  .scaleExtent([MIN_SCALE, ZOOM_ADAPTIVE_MAX_SCALE])
212
233
  .on("zoom", zoomed);
@@ -214,23 +235,14 @@ export var drawGraph = function (workbook) {
214
235
  svg.style("pointer-events", "all").call(zoomDrag)
215
236
  .style("font-family", "sans-serif");
216
237
 
217
-
238
+ // this allows zoomContainer to be zoomed, dragged
218
239
  function zoomed () {
219
240
  zoomContainer.attr("transform", d3.event.transform);
220
241
  }
221
242
 
222
243
  d3.select("svg").on("dblclick.zoom", null); // disables double click zooming
223
244
 
224
- // This rectangle catches all of the mousewheel and pan events, without letting
225
- // them bubble up to the body.
226
- boundingBoxContainer.append("rect")
227
- .attr("width", width)
228
- .attr("height", height)
229
- .style("fill", "none")
230
- .style("pointer-events", "all")
231
- .attr("stroke", "none" )
232
- .append("g");
233
-
245
+ // this controls the D-pad
234
246
  d3.selectAll(".scrollBtn").on("click", null); // Remove event handlers, if there were any.
235
247
  var arrowMovement = [ "Up", "Left", "Right", "Down" ];
236
248
  arrowMovement.forEach(function (direction) {
@@ -240,14 +252,39 @@ export var drawGraph = function (workbook) {
240
252
  });
241
253
  d3.select(".center").on("click", center);
242
254
 
255
+ let xTranslation = 0;
256
+ let yTranslation = 0;
257
+
258
+ function updateZoomContainerInfo () {
259
+ // transform attribute of zoomContainer contains translation info about graph
260
+ if (zoomContainer.attr("transform")) {
261
+ xTranslation = Number(
262
+ zoomContainer
263
+ .attr("transform")
264
+ .split("(")[1]
265
+ .split(",")[0]
266
+ );
267
+
268
+ yTranslation = Number(
269
+ zoomContainer
270
+ .attr("transform")
271
+ .split("(")[1]
272
+ .split(",")[1]
273
+ .split(")")[0]
274
+ );
275
+ }
276
+ }
277
+
278
+ // controls reading movement of zoomSlider and scaling graph to that zoomScale
243
279
  const setGraphZoom = zoomScale => {
244
280
  if (zoomScale < MIDDLE_SCALE) {
245
281
  $container.removeClass(CURSOR_CLASSES).addClass("cursorGrab");
246
- } else if (!adaptive && zoomScale >= MIDDLE_SCALE) {
247
- $container.removeClass(CURSOR_CLASSES);
248
282
  }
249
283
  var container = zoomContainer;
250
- zoom.scaleTo(container, zoomScale);
284
+ if (adaptive || (!adaptive && flexZoomInBounds(graphZoom))) {
285
+ zoom.scaleTo(container, zoomScale);
286
+ graphZoom = zoomScale;
287
+ }
251
288
  };
252
289
 
253
290
  // See setupZoomElements below to see how these are initialized. They are declared here because
@@ -255,15 +292,34 @@ export var drawGraph = function (workbook) {
255
292
  let sliderMidpoint;
256
293
  let zoomScaleSliderLeft;
257
294
  let zoomScaleSliderRight;
295
+ let prevGrnstateZoomVal;
296
+ let flexibleContainer = null;
258
297
 
259
298
  const updateAppBasedOnZoomValue = () => {
299
+ let zoomDisplay;
260
300
 
261
- if (!adaptive) {
262
- grnState.zoomValue = 100.0;
301
+ // If the zoom value is out of bounds, reset it to the previous value.
302
+ if (adaptive) {
303
+ zoomDisplay = grnState.zoomValue;
304
+ } else if (
305
+ !adaptive &&
306
+ flexZoomInBounds(
307
+ (grnState.zoomValue <= ZOOM_DISPLAY_MIDDLE
308
+ ? zoomScaleLeft
309
+ : zoomScaleRight)(grnState.zoomValue)
310
+ )
311
+ ) {
312
+ zoomDisplay = grnState.zoomValue;
313
+ } else {
314
+ grnState.zoomValue = prevGrnstateZoomVal;
315
+ zoomDisplay = grnState.zoomValue;
263
316
  }
264
317
 
265
- const zoomDisplay = grnState.zoomValue;
266
- setGraphZoom((zoomDisplay <= ZOOM_DISPLAY_MIDDLE ? zoomScaleLeft : zoomScaleRight)(zoomDisplay));
318
+ const calcGraphZoom = (zoomDisplay <= ZOOM_DISPLAY_MIDDLE
319
+ ? zoomScaleLeft
320
+ : zoomScaleRight)(zoomDisplay);
321
+
322
+ setGraphZoom(calcGraphZoom);
267
323
 
268
324
  const finalDisplay = grnState.zoomValue;
269
325
  $(ZOOM_PERCENT).text(`${finalDisplay}%`);
@@ -275,8 +331,21 @@ export var drawGraph = function (workbook) {
275
331
  $(ZOOM_INPUT).val(finalDisplay);
276
332
  }
277
333
 
278
- $(ZOOM_SLIDER).val((finalDisplay <= ZOOM_DISPLAY_MIDDLE ? zoomScaleSliderLeft : zoomScaleSliderRight)
279
- .invert(finalDisplay));
334
+ // This controls movement of slider and is where the zoomSlider can be restricted
335
+ if (adaptive || (!adaptive && flexZoomInBounds(calcGraphZoom))) {
336
+ if (!adaptive) {
337
+ // Recenter graph when zooming to ensure that graph stays in viewport
338
+ center();
339
+ updateZoomContainerInfo();
340
+ }
341
+
342
+ $(ZOOM_SLIDER).val(
343
+ (finalDisplay <= ZOOM_DISPLAY_MIDDLE
344
+ ? zoomScaleSliderLeft
345
+ : zoomScaleSliderRight
346
+ ).invert(finalDisplay)
347
+ );
348
+ }
280
349
  };
281
350
 
282
351
  /**
@@ -317,10 +386,15 @@ export var drawGraph = function (workbook) {
317
386
  }).blur(() => $(ZOOM_INPUT).val(grnState.zoomValue));
318
387
 
319
388
  d3.select(ZOOM_SLIDER).on("input", function () {
320
- const sliderValue = +$(this).val();
389
+ const sliderValue = $(this).val();
390
+ prevGrnstateZoomVal = grnState.zoomValue;
391
+
321
392
  grnState.zoomValue = Math.floor(
322
- (sliderValue <= sliderMidpoint ? zoomScaleSliderLeft : zoomScaleSliderRight)(sliderValue)
393
+ (sliderValue <= sliderMidpoint
394
+ ? zoomScaleSliderLeft
395
+ : zoomScaleSliderRight)(sliderValue)
323
396
  );
397
+
324
398
  updateAppBasedOnZoomValue();
325
399
  }).on("mousedown", function () {
326
400
  manualZoom = true;
@@ -359,20 +433,13 @@ export var drawGraph = function (workbook) {
359
433
  var restrictGraphToViewport = function (fixed) {
360
434
  if (!fixed) {
361
435
  $("#restrict-graph-to-viewport span").removeClass("glyphicon-ok");
362
- $(document).ready(function () {
363
- $(".scale-and-scroll").show();
364
- });
365
436
  $("input[name=viewport]").removeProp("checked");
366
- $container.addClass("cursorGrabbing");
367
437
  adaptive = true;
368
- d3.select("rect").attr("stroke", "none");
438
+ flexibleContainer = null;
369
439
  center();
370
- } else if (fixed) {
440
+ } else {
371
441
  $("#restrict-graph-to-viewport span").addClass("glyphicon-ok");
372
442
  $("input[name=viewport]").prop("checked", "checked");
373
- $(document).ready(function () {
374
- $(".scale-and-scroll").hide();
375
- });
376
443
  adaptive = false;
377
444
  $container.removeClass(CURSOR_CLASSES);
378
445
  if (grnState.zoomValue > ZOOM_DISPLAY_MIDDLE) {
@@ -382,13 +449,15 @@ export var drawGraph = function (workbook) {
382
449
  }
383
450
  width = $container.width();
384
451
  height = $container.height();
385
- d3.select("rect").attr("stroke", "#9A9A9A")
386
- .attr("width", width)
387
- .attr("height", height);
452
+ d3.select("rect")
453
+ .attr("width", width)
454
+ .attr("height", height);
388
455
  $(".boundingBox").attr("width", width).attr("height", height);
389
456
  center();
390
457
  }
391
458
  updateAppBasedOnZoomValue(); // Update zoom value within bounds
459
+ // Refresh the graph so that nodes and paths are adjusted to fit in viewport
460
+ tick();
392
461
  };
393
462
 
394
463
  d3.select("#restrict-graph-to-viewport").on("click", function () {
@@ -407,10 +476,17 @@ export var drawGraph = function (workbook) {
407
476
  zoom.translateTo(zoomContainer, viewportWidth / 2, viewportHeight / 2);
408
477
  }
409
478
 
479
+ // move: Moves graph with D-pad
410
480
  function move (direction) {
411
- var width = direction === "left" ? -50 : (direction === "right" ? 50 : 0);
412
- var height = direction === "up" ? -50 : (direction === "down" ? 50 : 0);
413
- zoom.translateBy(zoomContainer, width, height);
481
+ var moveWidth = direction === "left" ? -50 : direction === "right" ? 50 : 0;
482
+ var moveHeight = direction === "up" ? -50 : direction === "down" ? 50 : 0;
483
+ if (adaptive) {
484
+ zoom.translateBy(zoomContainer, moveWidth, moveHeight);
485
+ } else if (!adaptive) {
486
+ if (viewportBoundsMoveDrag(graphZoom, moveWidth, moveHeight)) {
487
+ zoom.translateBy(zoomContainer, moveWidth, moveHeight);
488
+ }
489
+ }
414
490
  }
415
491
 
416
492
  var defs = boundingBoxContainer.append("defs");
@@ -595,70 +671,72 @@ export var drawGraph = function (workbook) {
595
671
  });
596
672
  } else {
597
673
  // Arrowheads
598
- if (d.strokeWidth === 2) {
599
- d.strokeWidth = 4;
600
- }
601
- defs.append("marker")
602
- .attr("id", "arrowhead" + selfRef + "_StrokeWidth" + d.strokeWidth + minimum)
603
- .attr("viewBox", "0 0 15 15")
604
- .attr("preserveAspectRatio", "xMinYMin meet")
605
- .attr("refX", function () {
606
- // Individual offsets for each possible stroke width
607
- return ((x1 === x2 && y1 === y2) ?
608
- {
609
- 2: 2, 3: 10.5, 4: 11, 5: 9, 6: 9, 7: 10,
610
- 8: 9.8, 9: 9.1, 10: 10, 11: 9.5, 12: 9, 13: 8.3,
611
- 14: 8.3
612
- } : {
613
- 2: 11.75, 3: 11, 4: 9.75, 5: 9.25, 6: 8.5, 7: 10,
614
- 8: 9.75, 9: 9.5, 10: 9, 11: 9.5, 12: 9.5, 13: 9.25,
615
- 14: 9
616
- }
617
- )[d.strokeWidth];
618
- })
619
- .attr("refY", function () {
620
- return ((x1 === x2 && y1 === y2) ?
621
- {
622
- 2: 6.7, 3: 5.45, 4: 5.3, 5: 5.5, 6: 5, 7: 5.4,
623
- 8: 5.65, 9: 6, 10: 5.7, 11: 5.5, 12: 5.9, 13: 6,
624
- 14: 6
625
- } : {
626
- 2: 5, 3: 5, 4: 4.8, 5: 5, 6: 5, 7: 4.98,
627
- 8: 4.9, 9: 5.2, 10: 4.85, 11: 4.7, 12: 5.15,
628
- 13: 5, 14: 5.3
629
- }
630
- )[d.strokeWidth];
631
- })
632
- .attr("markerUnits", "userSpaceOnUse")
633
- .attr("markerWidth", function () {
634
- return 12 + ((d.strokeWidth < 7) ? d.strokeWidth * 2.25 : d.strokeWidth * 3);
635
- })
636
- .attr("markerHeight", function () {
637
- return 5 + ((d.strokeWidth < 7) ? d.strokeWidth * 2.25 : d.strokeWidth * 3);
638
- })
639
- .attr("orient", function () {
640
- return (x1 === x2 && y1 === y2) ?
674
+ if (grnState.mode === NETWORK_GRN_MODE) {
675
+ if (d.strokeWidth === 2) {
676
+ d.strokeWidth = 4;
677
+ }
678
+ defs.append("marker")
679
+ .attr("id", "arrowhead" + selfRef + "_StrokeWidth" + d.strokeWidth + minimum)
680
+ .attr("viewBox", "0 0 15 15")
681
+ .attr("preserveAspectRatio", "xMinYMin meet")
682
+ .attr("refX", function () {
683
+ // Individual offsets for each possible stroke width
684
+ return ((x1 === x2 && y1 === y2) ?
641
685
  {
642
- 2: 270, 3: 270, 4: 268, 5: 264, 6: 268, 7: 252,
643
- 8: 248, 9: 243, 10: 240, 11: 240, 12: 235, 13: 233,
644
- 14: 232
645
- }[d.strokeWidth] : "auto";
646
- })
647
- .append("path")
648
- .attr("d", "M 0 0 L 14 5 L 0 10 Q 6 5 0 0")
649
- .attr("style", function () {
650
- if (unweighted || !grnState.colorOptimal) {
651
- color = "black";
652
- } else if ( normalize(d) <= grayThreshold) {
653
- color = "gray";
654
- } else {
655
- color = d.stroke;
656
- }
657
- return "stroke: " + color + "; fill: " + color;
658
- });
686
+ 2: 2, 3: 10.5, 4: 11, 5: 9, 6: 9, 7: 10,
687
+ 8: 9.8, 9: 9.1, 10: 10, 11: 9.5, 12: 9, 13: 8.3,
688
+ 14: 8.3
689
+ } : {
690
+ 2: 11.75, 3: 11, 4: 9.75, 5: 9.25, 6: 8.5, 7: 10,
691
+ 8: 9.75, 9: 9.5, 10: 9, 11: 9.5, 12: 9.5, 13: 9.25,
692
+ 14: 9
693
+ }
694
+ )[d.strokeWidth];
695
+ })
696
+ .attr("refY", function () {
697
+ return ((x1 === x2 && y1 === y2) ?
698
+ {
699
+ 2: 6.7, 3: 5.45, 4: 5.3, 5: 5.5, 6: 5, 7: 5.4,
700
+ 8: 5.65, 9: 6, 10: 5.7, 11: 5.5, 12: 5.9, 13: 6,
701
+ 14: 6
702
+ } : {
703
+ 2: 5, 3: 5, 4: 4.8, 5: 5, 6: 5, 7: 4.98,
704
+ 8: 4.9, 9: 5.2, 10: 4.85, 11: 4.7, 12: 5.15,
705
+ 13: 5, 14: 5.3
706
+ }
707
+ )[d.strokeWidth];
708
+ })
709
+ .attr("markerUnits", "userSpaceOnUse")
710
+ .attr("markerWidth", function () {
711
+ return 12 + ((d.strokeWidth < 7) ? d.strokeWidth * 2.25 : d.strokeWidth * 3);
712
+ })
713
+ .attr("markerHeight", function () {
714
+ return 5 + ((d.strokeWidth < 7) ? d.strokeWidth * 2.25 : d.strokeWidth * 3);
715
+ })
716
+ .attr("orient", function () {
717
+ return (x1 === x2 && y1 === y2) ?
718
+ {
719
+ 2: 270, 3: 270, 4: 268, 5: 264, 6: 268, 7: 252,
720
+ 8: 248, 9: 243, 10: 240, 11: 240, 12: 235, 13: 233,
721
+ 14: 232
722
+ }[d.strokeWidth] : "auto";
723
+ })
724
+ .append("path")
725
+ .attr("d", "M 0 0 L 14 5 L 0 10 Q 6 5 0 0")
726
+ .attr("style", function () {
727
+ if (unweighted || !grnState.colorOptimal) {
728
+ color = "black";
729
+ } else if ( normalize(d) <= grayThreshold) {
730
+ color = "gray";
731
+ } else {
732
+ color = d.stroke;
733
+ }
734
+ return "stroke: " + color + "; fill: " + color;
735
+ });
736
+ }
659
737
  }
738
+ return "url(#" + d.type + selfRef + "_StrokeWidth" + d.strokeWidth + minimum + ")";
660
739
  }
661
- return "url(#" + d.type + selfRef + "_StrokeWidth" + d.strokeWidth + minimum + ")";
662
740
  });
663
741
 
664
742
  if (workbook.sheetType === "weighted") {
@@ -1008,12 +1086,20 @@ export var drawGraph = function (workbook) {
1008
1086
  .append("g")
1009
1087
  .selectAll(".coloring")
1010
1088
  .data(function () {
1011
- if (grnState.workbook.expression[dataset].data[p.name]) {
1012
- const result = getExpressionData(p.name, dataset, average);
1013
- timePoints = result.timePoints;
1014
- return result.data;
1015
- } else {
1016
- return 0;
1089
+ if (grnState.workbook.expression[dataset]) {
1090
+ if (
1091
+ grnState.workbook.expression[dataset].data[p.name]
1092
+ ) {
1093
+ const result = getExpressionData(
1094
+ p.name,
1095
+ dataset,
1096
+ average
1097
+ );
1098
+ timePoints = result.timePoints;
1099
+ return result.data;
1100
+ } else {
1101
+ return 0;
1102
+ }
1017
1103
  }
1018
1104
  })
1019
1105
  .attr("class", "coloring")
@@ -1297,6 +1383,122 @@ export var drawGraph = function (workbook) {
1297
1383
  }
1298
1384
  };
1299
1385
 
1386
+ const BOUNDARY_MARGIN = 5;
1387
+
1388
+ function viewportBoundsMoveDrag (graphZoom, dx, dy) {
1389
+ updateZoomContainerInfo();
1390
+ flexibleContainer = calcFlexiBox();
1391
+
1392
+ if (
1393
+ flexibleContainer.x + flexibleContainer.width + dx >=
1394
+ -xTranslation / graphZoom +
1395
+ BOUNDARY_MARGIN / 2 +
1396
+ width / graphZoom -
1397
+ BOUNDARY_MARGIN
1398
+ ) {
1399
+ return false;
1400
+ }
1401
+
1402
+ if (flexibleContainer.x + dx <= getLeftXBoundaryMargin()) {
1403
+ return false;
1404
+ }
1405
+
1406
+ if (
1407
+ flexibleContainer.y + flexibleContainer.height + dy >=
1408
+ -yTranslation / graphZoom +
1409
+ BOUNDARY_MARGIN / 2 +
1410
+ height / graphZoom -
1411
+ BOUNDARY_MARGIN
1412
+ ) {
1413
+ return false;
1414
+ }
1415
+
1416
+ if (flexibleContainer.y + dy <= getTopYBoundaryMargin()) {
1417
+ return false;
1418
+ }
1419
+
1420
+ return true;
1421
+ }
1422
+
1423
+ function calcFlexiBox () {
1424
+ const nodes = simulation.nodes();
1425
+ let nodeWidth = 0;
1426
+ if (nodes.length > 0) {
1427
+ nodeWidth = nodes[0].textWidth + 8;
1428
+ }
1429
+
1430
+ const xValuesNodes = nodes.map((node) => node.x);
1431
+ const yValuesNodes = nodes.map((node) => node.y);
1432
+
1433
+ let minX = Math.min(...xValuesNodes);
1434
+ let maxX = Math.max(...xValuesNodes) + nodeWidth;
1435
+
1436
+ let minY = Math.min(...yValuesNodes);
1437
+ let maxY = Math.max(...yValuesNodes) + nodeHeight;
1438
+
1439
+ // Handle left x and top y boundaries to not exceed graph BOUNDARY_MARGINs
1440
+ const BOUNDARY_MARGIN_X_L = getLeftXBoundaryMargin();
1441
+ const BOUNDARY_MARGIN_Y_T = getTopYBoundaryMargin();
1442
+ minX = minX < BOUNDARY_MARGIN_X_L ? BOUNDARY_MARGIN_X_L : minX;
1443
+ minY = minY < BOUNDARY_MARGIN_Y_T ? BOUNDARY_MARGIN_Y_T : minY;
1444
+
1445
+ maxX =
1446
+ maxX > -xTranslation / graphZoom + BOUNDARY_MARGIN / 2 + width / graphZoom - BOUNDARY_MARGIN
1447
+ ? -xTranslation / graphZoom + BOUNDARY_MARGIN / 2 + width / graphZoom - BOUNDARY_MARGIN
1448
+ : maxX;
1449
+
1450
+ maxY =
1451
+ maxY > -yTranslation / graphZoom + BOUNDARY_MARGIN / 2 + height / graphZoom - BOUNDARY_MARGIN
1452
+ ? -yTranslation / graphZoom + BOUNDARY_MARGIN / 2 + height / graphZoom - BOUNDARY_MARGIN
1453
+ : maxY;
1454
+
1455
+ let flexiBoxWidth = maxX - minX;
1456
+ if (maxX < 0 && minX < 0) {
1457
+ flexiBoxWidth = Math.abs(maxX) - Math.abs(minX);
1458
+ }
1459
+
1460
+ let flexiBoxHeight = maxY - minY;
1461
+ if (maxY < 0 && minY < 0) {
1462
+ flexiBoxHeight = Math.abs(maxY) - Math.abs(minY);
1463
+ }
1464
+
1465
+ boundingBoxRect
1466
+ .attr("x", -xTranslation / graphZoom + BOUNDARY_MARGIN / 2)
1467
+ .attr("width", width / graphZoom - BOUNDARY_MARGIN)
1468
+ .attr("y", -yTranslation / graphZoom + BOUNDARY_MARGIN / 2)
1469
+ .attr("height", height / graphZoom - BOUNDARY_MARGIN);
1470
+
1471
+ flexibleContainerRect
1472
+ .attr("x", minX)
1473
+ .attr("y", minY)
1474
+ .attr("width", flexiBoxWidth)
1475
+ .attr("height", flexiBoxHeight);
1476
+ return {x: minX, y: minY, maxX: maxX, maxY: maxY, width: flexiBoxWidth, height: flexiBoxHeight};
1477
+ }
1478
+
1479
+ // Checks if zoomValue is in bounds when zoom in and out
1480
+ function flexZoomInBounds (zoomValue) {
1481
+ if (flexibleContainer) {
1482
+ updateZoomContainerInfo();
1483
+ flexibleContainer = calcFlexiBox();
1484
+ if (flexibleContainer.width * zoomValue > width ) {
1485
+ return false;
1486
+ } else if (flexibleContainer.height * zoomValue > height) {
1487
+ return false;
1488
+ }
1489
+ }
1490
+ return true;
1491
+ }
1492
+
1493
+ // Only calculate Left and Top boundary margins because calculate rightboundary and bottomboundary in tick
1494
+ function getLeftXBoundaryMargin () {
1495
+ return !adaptive && flexibleContainer ? -xTranslation / graphZoom + BOUNDARY_MARGIN / 2 : BOUNDARY_MARGIN;
1496
+ }
1497
+
1498
+ function getTopYBoundaryMargin () {
1499
+ return !adaptive && flexibleContainer ? -yTranslation / graphZoom + BOUNDARY_MARGIN / 2 : BOUNDARY_MARGIN;
1500
+ }
1501
+
1300
1502
  // Tick only runs while the graph physics are still running.
1301
1503
  // (I.e. when the graph is completely relaxed, tick stops running.)
1302
1504
  function tick () {
@@ -1310,12 +1512,17 @@ export var drawGraph = function (workbook) {
1310
1512
  var getSelfReferringRadius = function (edge) {
1311
1513
  return edge ? 17 + (getEdgeThickness(edge) / 2) : 0;
1312
1514
  };
1313
- var BOUNDARY_MARGIN = 5;
1515
+
1314
1516
  var SELF_REFERRING_Y_OFFSET = 6;
1315
1517
  var MAX_WIDTH = 5000;
1316
1518
  var MAX_HEIGHT = 5000;
1317
1519
  var OFFSET_VALUE = 5;
1318
1520
 
1521
+ if (!adaptive) {
1522
+ flexibleContainer = calcFlexiBox();
1523
+ }
1524
+
1525
+ // this controls movement and position of nodes, clamps the nodes to boundary
1319
1526
  try {
1320
1527
  node.attr("x", function (d) {
1321
1528
  var selfReferringEdge = getSelfReferringEdge(d);
@@ -1323,25 +1530,38 @@ export var drawGraph = function (workbook) {
1323
1530
  var selfReferringEdgeWidth = (selfReferringEdge ? getSelfReferringRadius(selfReferringEdge) +
1324
1531
  selfReferringEdge.strokeWidth + 2 : 0);
1325
1532
  var rightBoundary = width - (d.textWidth + OFFSET_VALUE) - BOUNDARY_MARGIN - selfReferringEdgeWidth;
1326
- var currentXPos = Math.max(BOUNDARY_MARGIN, Math.min(rightBoundary, d.x));
1327
- if (adaptive && width < MAX_WIDTH &&
1328
- (currentXPos === BOUNDARY_MARGIN || currentXPos === rightBoundary)) {
1533
+ if (!adaptive) {
1534
+ rightBoundary =
1535
+ -xTranslation / graphZoom +
1536
+ BOUNDARY_MARGIN / 2 +
1537
+ width / graphZoom -
1538
+ BOUNDARY_MARGIN -
1539
+ (d.textWidth + OFFSET_VALUE) -
1540
+ selfReferringEdgeWidth;
1541
+ }
1542
+ // currentXPos bounds the graph when toggle to !adaptive and moves each of the nodes to be in bounds
1543
+ var currentXPos = Math.max(getLeftXBoundaryMargin(), Math.min(rightBoundary, d.x));
1544
+ if (
1545
+ adaptive &&
1546
+ width < MAX_WIDTH &&
1547
+ (currentXPos === getLeftXBoundaryMargin() ||
1548
+ currentXPos === rightBoundary)
1549
+ ) {
1329
1550
  if (!d3.select(this).classed("fixed")) {
1330
1551
  width += OFFSET_VALUE;
1331
1552
  boundingBoxContainer.attr("width", width);
1332
1553
 
1333
1554
  link
1334
- .attr("x1", function (d) {
1335
- return d.source.x;
1336
- })
1337
- .attr("x2", function (d) {
1338
- return d.target.x;
1339
- });
1555
+ .attr("x1", function (d) {
1556
+ return d.source.x;
1557
+ })
1558
+ .attr("x2", function (d) {
1559
+ return d.target.x;
1560
+ });
1340
1561
 
1341
- node
1342
- .attr("x", function (d) {
1343
- return d.x;
1344
- });
1562
+ node.attr("x", function (d) {
1563
+ return d.x;
1564
+ });
1345
1565
  }
1346
1566
  }
1347
1567
  return d.x = currentXPos;
@@ -1350,24 +1570,34 @@ export var drawGraph = function (workbook) {
1350
1570
  var selfReferringEdgeHeight = (selfReferringEdge ? getSelfReferringRadius(selfReferringEdge) +
1351
1571
  selfReferringEdge.strokeWidth + SELF_REFERRING_Y_OFFSET + 0.5 : 0);
1352
1572
  var bottomBoundary = height - nodeHeight - BOUNDARY_MARGIN - selfReferringEdgeHeight;
1353
- var currentYPos = Math.max(BOUNDARY_MARGIN, Math.min(bottomBoundary, d.y));
1573
+ if (!adaptive) {
1574
+ bottomBoundary =
1575
+ -yTranslation / graphZoom +
1576
+ BOUNDARY_MARGIN / 2 +
1577
+ height / graphZoom -
1578
+ BOUNDARY_MARGIN -
1579
+ nodeHeight -
1580
+ selfReferringEdgeHeight;
1581
+ }
1582
+ // currentYPos bounds the graph when toggle to !adaptive and moves each of the nodes to be in bounds
1583
+ var currentYPos = Math.max(getTopYBoundaryMargin(), Math.min(bottomBoundary, d.y));
1584
+
1354
1585
  if (adaptive && height < MAX_HEIGHT &&
1355
- (currentYPos === BOUNDARY_MARGIN || currentYPos === bottomBoundary)) {
1586
+ (currentYPos === getTopYBoundaryMargin() || currentYPos === bottomBoundary)) {
1356
1587
  if (!d3.select(this).classed("fixed")) {
1357
1588
  height += OFFSET_VALUE;
1358
1589
  boundingBoxContainer.attr("height", height);
1359
1590
  link
1360
- .attr("y1", function (d) {
1361
- return d.source.y;
1362
- })
1363
- .attr("y2", function (d) {
1364
- return d.target.y;
1365
- });
1591
+ .attr("y1", function (d) {
1592
+ return d.source.y;
1593
+ })
1594
+ .attr("y2", function (d) {
1595
+ return d.target.y;
1596
+ });
1366
1597
 
1367
- node
1368
- .attr("y", function (d) {
1369
- return d.y;
1370
- });
1598
+ node.attr("y", function (d) {
1599
+ return d.y;
1600
+ });
1371
1601
  }
1372
1602
  }
1373
1603
  return d.y = currentYPos;
@@ -1403,7 +1633,6 @@ export var drawGraph = function (workbook) {
1403
1633
  var ADDITIONAL_SHIFT = 0.07;
1404
1634
  var END_POINT_ADJUSTMENT = 1.2;
1405
1635
 
1406
-
1407
1636
  // Self edge.
1408
1637
  if (x1 === x2 && y1 === y2) {
1409
1638
  // Move the position of the loop.
@@ -1499,8 +1728,49 @@ export var drawGraph = function (workbook) {
1499
1728
  }
1500
1729
 
1501
1730
  function dragged (d) {
1502
- d.fx = d3.event.x;
1503
- d.fy = d3.event.y;
1731
+ if (!adaptive) {
1732
+ /* fx and fy stands for fixed x and y which is when node is fixed to a position or
1733
+ to prevent tick from adjusting position of node
1734
+ */
1735
+ // prevents nodes from being dragged outside of right boundary
1736
+ if (
1737
+ d3.event.x + d.textWidth <=
1738
+ -xTranslation / graphZoom + BOUNDARY_MARGIN / 2 +
1739
+ width / graphZoom -
1740
+ BOUNDARY_MARGIN
1741
+ ) {
1742
+ d.fx = d3.event.x;
1743
+ } else {
1744
+ d.fx =
1745
+ -xTranslation / graphZoom +
1746
+ BOUNDARY_MARGIN / 2 +
1747
+ width / graphZoom -
1748
+ BOUNDARY_MARGIN -
1749
+ d.textWidth;
1750
+ }
1751
+
1752
+ // prevent nodes from being dragged out of bottom boundary
1753
+ if (
1754
+ d3.event.y + nodeHeight <=
1755
+ -yTranslation / graphZoom +
1756
+ BOUNDARY_MARGIN / 2 +
1757
+ height / graphZoom -
1758
+ BOUNDARY_MARGIN
1759
+ ) {
1760
+ // fy stands for fixed y
1761
+ d.fy = d3.event.y;
1762
+ } else {
1763
+ d.fy =
1764
+ -yTranslation / graphZoom +
1765
+ BOUNDARY_MARGIN / 2 +
1766
+ height / graphZoom -
1767
+ BOUNDARY_MARGIN -
1768
+ nodeHeight;
1769
+ }
1770
+ } else {
1771
+ d.fx = d3.event.x;
1772
+ d.fy = d3.event.y;
1773
+ }
1504
1774
  }
1505
1775
 
1506
1776
  grnState.simulation = simulation;