grnsight 6.0.4 → 7.1.1
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/.eslintrc.yml +4 -4
- package/database/README.md +224 -79
- package/database/constants.py +42 -0
- package/database/expression-database/README.md +2 -2
- package/database/expression-database/schema.sql +14 -14
- package/database/expression-database/scripts/loader.py +6 -6
- package/database/filter_update.py +168 -0
- package/database/grnsettings-database/README.md +52 -0
- package/database/grnsettings-database/schema.sql +4 -0
- package/database/loader.py +30 -0
- package/database/loader_update.py +36 -0
- package/database/network-database/README.md +36 -4
- package/database/network-database/schema.sql +7 -7
- package/database/network-database/scripts/generate_network.py +16 -24
- package/database/network-database/scripts/generate_new_network_version.py +216 -0
- package/database/protein-protein-database/README.md +71 -0
- package/database/protein-protein-database/schema.sql +37 -0
- package/database/protein-protein-database/scripts/generate_protein_network.py +227 -0
- package/database/protein-protein-database/scripts/remove_duplicates.sh +4 -0
- package/database/utils.py +418 -0
- package/package.json +2 -2
- package/server/app.js +2 -0
- package/server/config/config.js +4 -4
- package/server/controllers/additional-sheet-parser.js +2 -1
- package/server/controllers/constants.js +5 -0
- package/server/controllers/custom-workbook-controller.js +8 -6
- package/server/controllers/demo-workbooks.js +1460 -4
- package/server/controllers/export-constants.js +3 -2
- package/server/controllers/exporters/sif.js +6 -1
- package/server/controllers/exporters/xlsx.js +8 -3
- package/server/controllers/expression-sheet-parser.js +0 -6
- package/server/controllers/grnsettings-database-controller.js +17 -0
- package/server/controllers/importers/sif.js +29 -11
- package/server/controllers/network-database-controller.js +2 -2
- package/server/controllers/network-sheet-parser.js +54 -12
- package/server/controllers/protein-database-controller.js +18 -0
- package/server/controllers/sif-constants.js +4 -4
- package/server/controllers/spreadsheet-controller.js +44 -1
- package/server/controllers/workbook-constants.js +21 -4
- package/server/dals/expression-dal.js +8 -7
- package/server/dals/grnsetting-dal.js +49 -0
- package/server/dals/network-dal.js +13 -12
- package/server/dals/protein-dal.js +106 -0
- package/test/export-tests.js +136 -9
- package/test/import-sif-tests.js +54 -13
- package/test/test.js +1 -1
- package/test-files/additional-sheet-test-files/optimization-parameters-default.xlsx +0 -0
- package/test-files/demo-files/18_proteins_81_edges_PPI.xlsx +0 -0
- package/test-files/expression-data-test-sheets/expression_sheet_missing_data_ok_export_exact.xlsx +0 -0
- package/web-client/config/config.js +4 -4
- package/web-client/public/js/api/grnsight-api.js +72 -56
- package/web-client/public/js/constants.js +26 -12
- package/web-client/public/js/generateNetwork.js +173 -67
- package/web-client/public/js/graph.js +420 -150
- package/web-client/public/js/grnsight.js +25 -4
- package/web-client/public/js/grnstate.js +3 -1
- package/web-client/public/js/iframe-coordination.js +3 -3
- package/web-client/public/js/setup-handlers.js +28 -32
- package/web-client/public/js/setup-load-and-import-handlers.js +196 -170
- package/web-client/public/js/update-app.js +84 -17
- package/web-client/public/js/upload.js +193 -157
- package/web-client/public/lib/bootstrap.file-input/bootstrap.file-input.js +0 -1
- package/web-client/public/stylesheets/grnsight.styl +40 -16
- package/web-client/views/components/demo.pug +7 -5
- package/web-client/views/upload.pug +63 -49
- package/.bundle/config +0 -3
- package/GRNsight - Beta.html +0 -194
- package/Gemfile.lock +0 -259
- package/_gh_pages/about.html +0 -807
- package/_gh_pages/assets/css/bootstrap.min.css +0 -10
- package/_gh_pages/assets/css/footer.css +0 -3
- package/_gh_pages/assets/css/main.css +0 -363
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_estimation_output_binary-no-targetless-genes_sif.png +0 -0
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_estimation_output_binary_sif.png +0 -0
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_graphml_3-edges-and-footer.png +0 -0
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_graphml_header-and-3-nodes.png +0 -0
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_graphml_output_3-edges-and-footer.png +0 -0
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_graphml_output_header-and-3-nodes.png +0 -0
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_input_binary-no-targetless-genes_sif.png +0 -0
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_input_binary_sif.png +0 -0
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_input_concatenated-no-targetless-genes_sif.png +0 -0
- package/_gh_pages/assets/images/21-genes_31-edges_Schade-data_input_concatenated_sif.png +0 -0
- package/_gh_pages/assets/images/Carrillo_Roque_LMU_Symposium_2015.pptx +0 -0
- package/_gh_pages/assets/images/Choe-Shin_CMSI402-poster-session_20180430.jpg +0 -0
- package/_gh_pages/assets/images/Choe_SCCUR_2017.jpg +0 -0
- package/_gh_pages/assets/images/Dahlquist-BMB-2015-Fig1.jpg +0 -0
- package/_gh_pages/assets/images/Dahlquist-BMB-2015-Fig8.jpg +0 -0
- package/_gh_pages/assets/images/Dahlquist-Choe-Shin_CMSI402-poster-session_20180430.jpg +0 -0
- package/_gh_pages/assets/images/Demo-3-auto-layout.jpg +0 -0
- package/_gh_pages/assets/images/Demo-3-paper-layout.jpg +0 -0
- package/_gh_pages/assets/images/Demo-4-auto-layout.jpg +0 -0
- package/_gh_pages/assets/images/Demo-4-paper-layout.jpg +0 -0
- package/_gh_pages/assets/images/Dionisio-Dahlquist_GRNsight-shades_20170506.jpg +0 -0
- package/_gh_pages/assets/images/GRNsight_logo_20140710_main.jpg +0 -0
- package/_gh_pages/assets/images/GRNsight_logo_20140710_main_resized.jpg +0 -0
- package/_gh_pages/assets/images/GRNsight_logo_20140710_rollover.jpg +0 -0
- package/_gh_pages/assets/images/GRNsight_logo_20140710_rollover_resized.jpg +0 -0
- package/_gh_pages/assets/images/Johnson_Williams_LMU_Symposium_2015.pptx +0 -0
- package/_gh_pages/assets/images/Klein_Samdarshi_TriBeta_2018_20180317.jpg +0 -0
- package/_gh_pages/assets/images/LMULogoHQ2.png +0 -0
- package/_gh_pages/assets/images/LMUSymposium_Group_20150321-2.jpg +0 -0
- package/_gh_pages/assets/images/LMUSymposium_Group_20150321-2_resized.jpg +0 -0
- package/_gh_pages/assets/images/Sample_network_optimized_weights_worksheet.jpg +0 -0
- package/_gh_pages/assets/images/Sample_network_worksheet.jpg +0 -0
- package/_gh_pages/assets/images/Shin_SCCUR_2017.jpg +0 -0
- package/_gh_pages/assets/images/demo-3_network-sheet.png +0 -0
- package/_gh_pages/assets/images/demo-4_network-optimized-weights-sheet.png +0 -0
- package/_gh_pages/assets/images/gene-pages-0.png +0 -0
- package/_gh_pages/assets/images/gene-pages-1.png +0 -0
- package/_gh_pages/assets/images/gene-pages-2.png +0 -0
- package/_gh_pages/assets/images/gene-pages-3.png +0 -0
- package/_gh_pages/assets/images/grnsight2020.png +0 -0
- package/_gh_pages/assets/images/lmu logo.gif +0 -0
- package/_gh_pages/assets/images/v3demo2-grid+nodecoloring.png +0 -0
- package/_gh_pages/assets/images/v3demo2-nodecoloring.png +0 -0
- package/_gh_pages/assets/images/v3demo2.png +0 -0
- package/_gh_pages/assets/js/ga-report.js +0 -35
- package/_gh_pages/assets/js/iframeResizer.min.js +0 -9
- package/_gh_pages/assets/js/main.js +0 -132
- package/_gh_pages/beta.html +0 -144
- package/_gh_pages/contact.html +0 -178
- package/_gh_pages/coverage/coverage.json +0 -1
- package/_gh_pages/coverage/coverage.raw.json +0 -1
- package/_gh_pages/coverage/lcov-report/base.css +0 -223
- package/_gh_pages/coverage/lcov-report/block-navigation.js +0 -63
- package/_gh_pages/coverage/lcov-report/controllers/additional-sheet-parser.js.html +0 -330
- package/_gh_pages/coverage/lcov-report/controllers/constants.js.html +0 -243
- package/_gh_pages/coverage/lcov-report/controllers/export-controller.js.html +0 -285
- package/_gh_pages/coverage/lcov-report/controllers/exporters/graphml.js.html +0 -405
- package/_gh_pages/coverage/lcov-report/controllers/exporters/index.html +0 -110
- package/_gh_pages/coverage/lcov-report/controllers/exporters/sif.js.html +0 -150
- package/_gh_pages/coverage/lcov-report/controllers/helpers.js.html +0 -114
- package/_gh_pages/coverage/lcov-report/controllers/import-controller.js.html +0 -233
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- package/_gh_pages/coverage/lcov-report/controllers/semantic-checker.js.html +0 -810
- package/_gh_pages/coverage/lcov-report/controllers/spreadsheet-controller.js.html +0 -1779
- package/_gh_pages/coverage/lcov-report/index.html +0 -136
- package/_gh_pages/coverage/lcov-report/prettify.css +0 -1
- package/_gh_pages/coverage/lcov-report/prettify.js +0 -1
- package/_gh_pages/coverage/lcov-report/server/controllers/additional-sheet-parser.js.html +0 -330
- package/_gh_pages/coverage/lcov-report/server/controllers/constants.js.html +0 -243
- package/_gh_pages/coverage/lcov-report/server/controllers/export-controller.js.html +0 -285
- package/_gh_pages/coverage/lcov-report/server/controllers/exporters/graphml.js.html +0 -405
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- package/_gh_pages/coverage/lcov-report/server/controllers/importers/sif.js.html +0 -492
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- package/_gh_pages/coverage/lcov-report/server/controllers/semantic-checker.js.html +0 -810
- package/_gh_pages/coverage/lcov-report/server/controllers/spreadsheet-controller.js.html +0 -1779
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- package/_gh_pages/coverage/lcov-report/sorter.js +0 -158
- package/_gh_pages/coverage/lcov-report/web-client/public/js/grnstate.js.html +0 -225
- package/_gh_pages/coverage/lcov-report/web-client/public/js/index.html +0 -97
- package/_gh_pages/coverage/lcov.info +0 -49
- package/_gh_pages/documentation.html +0 -1132
- package/_gh_pages/documents/abstracts/SIGGRAPH 2017 Abstract/siggraph-abstract-review.aux +0 -47
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- package/_gh_pages/onlyheader.html +0 -64
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- package/gdb/global/pg_control +0 -0
- package/gdb/global/pg_filenode.map +0 -0
- package/gdb/global/pg_internal.init +0 -0
- package/gdb/pg_hba.conf +0 -98
- package/gdb/pg_ident.conf +0 -42
- package/gdb/pg_logical/replorigin_checkpoint +0 -0
- package/gdb/pg_multixact/members/0000 +0 -0
- package/gdb/pg_multixact/offsets/0000 +0 -0
- package/gdb/pg_stat/db_0.stat +0 -0
- package/gdb/pg_stat/db_14034.stat +0 -0
- package/gdb/pg_stat/global.stat +0 -0
- package/gdb/pg_subtrans/0000 +0 -0
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- package/gdb/pg_xact/0000 +0 -0
- package/gdb/postgresql.auto.conf +0 -2
- package/gdb/postgresql.conf +0 -796
- package/gdb/postmaster.opts +0 -1
- package/server/API Project-7d45e9f24a96.p12 +0 -0
- package/server/grnmap.pem +0 -31
- package/server/grnsight.pem +0 -19
- package/test-files/import-samples/attributes.graphml +0 -40
- package/test-files/import-samples/port.graphml +0 -32
- package/test-files/import-samples/simple.graphml +0 -31
- package/web-client/public/js/grnsight.min.js +0 -2371
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@@ -45,12 +45,11 @@ import {
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CHARGE_SLIDER_SIDEBAR,
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CHARGE_MENU,
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CHARGE_VALUE,
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GRID_LAYOUT_MENU,
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FORCE_GRAPH_MENU,
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LAYOUT_SIDEBAR_PANEL,
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NODE_COLORING_MENU,
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NODE_COLORING_TOGGLE_MENU,
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NODE_COLORING_MENU_CLASS,
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NODE_COLORING_NAVBAR_OPTIONS,
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NODE_COLORING_SIDEBAR_BODY,
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NODE_COLORING_SIDEBAR_PANEL,
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NODE_COLORING_SIDEBAR_HEADER_LINK,
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@@ -104,6 +103,13 @@ import {
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VIEWPORT_SIZE_L_SIDEBAR,
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VIEWPORT_SIZE_FIT_SIDEBAR,
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VIEWPORT_INIT,
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NETWORK_MODE_DROPDOWN,
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NETWORK_MODE_CLASS,
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NETWORK_MODE_PROTEIN_PHYS,
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NETWORK_MODE_GRN,
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EXPORT_TO_UNWEIGHTED_GML_MENU,
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NETWORK_GRN_MODE,
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NETWORK_PPI_MODE
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// EXPRESSION_SOURCE,
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} from "./constants";
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@@ -128,7 +134,6 @@ const refreshApp = () => {
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const displayworkbook = (workbook, name) => {
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uploadState.currentWorkbook = workbook;
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// console.log("workbook: ", workbook); // Display the workbook in the console
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$("#graph-metadata").html(workbook.genes.length + " nodes<br>" + workbook.links.length + " edges");
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if (workbook.warnings.length > 0) {
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@@ -389,7 +394,7 @@ const loadExpressionDatabase = function (isTopDataset) {
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queryExpressionDatabase({
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type:"ExpressionData",
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dataset,
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genes : grnState.workbook.genes.map(
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genes : grnState.workbook.genes.map(gene => {return gene.name;}).join(","),
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timepoints: timepointsResponse[dataset]
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}).then(function (response) {
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if (isTopDataset) {
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@@ -417,13 +422,11 @@ const loadExpressionDatabase = function (isTopDataset) {
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const updateSliderState = slidersLocked => {
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const forceGraphDisabled = grnState.graphLayout === GRID_LAYOUT || slidersLocked;
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if (forceGraphDisabled) {
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$(`${LOCK_SLIDERS_MENU} span`).removeClass("invisible").addClass("glyphicon-ok");
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$(RESET_SLIDERS_MENU).parent().addClass("disabled");
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$(UNDO_SLIDERS_RESET_MENU).parent().addClass("disabled");
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$(LINK_DIST_CLASS).parent().addClass("disabled");
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$(CHARGE_CLASS).parent().addClass("disabled");
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} else {
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$(`${LOCK_SLIDERS_MENU} span`).removeClass("glyphicon-ok").addClass("invisible");
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$(RESET_SLIDERS_MENU).parent().removeClass("disabled");
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$(UNDO_SLIDERS_RESET_MENU).parent().removeClass("disabled");
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$(LINK_DIST_CLASS).parent().removeClass("disabled");
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@@ -433,6 +436,17 @@ const updateSliderState = slidersLocked => {
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$(LINK_DIST_SLIDER_SIDEBAR).prop("disabled", forceGraphDisabled);
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$(CHARGE_SLIDER_SIDEBAR).prop("disabled", forceGraphDisabled);
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$(RESET_SLIDERS_SIDEBAR).prop("disabled", forceGraphDisabled);
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+
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if (slidersLocked) {
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$(`${LOCK_SLIDERS_MENU} span`)
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.removeClass("invisible")
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.addClass("glyphicon-ok");
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} else {
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$(`${LOCK_SLIDERS_MENU} span`)
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.removeClass("glyphicon-ok")
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.addClass("invisible");
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}
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$(LOCK_SLIDERS_BUTTON).prop("checked", slidersLocked);
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if (!grnState.showUndoReset) {
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@@ -488,15 +502,9 @@ const toggleLayout = (on, off) => {
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}
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};
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const updatetoForceGraph = () => {
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$(LOCK_SLIDERS_BUTTON).removeAttr("disabled");
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-
toggleLayout(FORCE_GRAPH_MENU, GRID_LAYOUT_MENU);
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};
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const updatetoForceGraph = () => {};
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const updatetoGridLayout = () => {
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$(LOCK_SLIDERS_BUTTON).attr("disabled", true);
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toggleLayout(GRID_LAYOUT_MENU, FORCE_GRAPH_MENU);
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-
};
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507
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+
const updatetoGridLayout = () => {};
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// Node Coloring Functions
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const showNodeColoringMenus = () => {
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@@ -510,8 +518,8 @@ const showNodeColoringMenus = () => {
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const disableNodeColoringMenus = () => {
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$(NODE_COLORING_SIDEBAR_PANEL).addClass("disabled");
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$(NODE_COLORING_SIDEBAR_PANEL).removeClass("in");
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$(NODE_COLORING_MENU).addClass("disabled");
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$(NODE_COLORING_MENU_CLASS).addClass("disabled");
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$(NODE_COLORING_MENU).addClass("disabled");
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$(NODE_COLORING_SIDEBAR_HEADER_LINK).attr("data-toggle", "");
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};
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@@ -519,6 +527,61 @@ const isNewWorkbook = (name) => {
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return grnState.nodeColoring.lastDataset === null || grnState.nodeColoring.lastDataset !== name;
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};
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// Workbook Mode Functions
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const updateModeViews = () =>{
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// Select correct dropdown item
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$(`${NETWORK_MODE_DROPDOWN} option`).removeAttr("selected");
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$(`${NETWORK_MODE_DROPDOWN} option[value="${grnState.mode}"]`).prop("selected", true);
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// Select the correct menu items
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$(`${NETWORK_MODE_CLASS} option`).removeAttr("checked");
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if (grnState.mode === NETWORK_GRN_MODE) {
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toggleLayout(NETWORK_MODE_GRN, NETWORK_MODE_PROTEIN_PHYS);
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} else if (grnState.mode === NETWORK_PPI_MODE) {
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toggleLayout(NETWORK_MODE_PROTEIN_PHYS, NETWORK_MODE_GRN);
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}
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};
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const checkWorkbookModeSettings = () => {
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if (grnState.mode === NETWORK_PPI_MODE) {
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grnState.nodeColoring.nodeColoringEnabled = false;
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grnState.colorOptimal = false;
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disableNodeColoringMenus();
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hideEdgeWeightOptions();
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updateModeViews();
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} else if (grnState.mode === NETWORK_GRN_MODE) {
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grnState.nodeColoring.nodeColoringEnabled = true;
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grnState.colorOptimal = true;
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showNodeColoringMenus();
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showEdgeWeightOptions();
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updateModeViews();
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}
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};
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$("body").on("click", () => {
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if (grnState.mode === NETWORK_PPI_MODE) {
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$(EXPORT_TO_UNWEIGHTED_GML_MENU).addClass("disabled");
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} else if (grnState.mode === NETWORK_GRN_MODE) {
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$(EXPORT_TO_UNWEIGHTED_GML_MENU).removeClass("disabled");
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}
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567
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});
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568
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569
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+
$(NETWORK_MODE_DROPDOWN).on("change", () => {
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+
grnState.mode = $(NETWORK_MODE_DROPDOWN).val();
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+
checkWorkbookModeSettings();
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refreshApp();
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+
});
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+
$(NETWORK_MODE_PROTEIN_PHYS).on("click", () => {
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+
grnState.mode = NETWORK_PPI_MODE;
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+
checkWorkbookModeSettings();
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+
refreshApp();
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578
|
+
});
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579
|
+
$(NETWORK_MODE_GRN).on("click", () => {
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580
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+
grnState.mode = NETWORK_GRN_MODE;
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581
|
+
checkWorkbookModeSettings();
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582
|
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refreshApp();
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583
|
+
});
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584
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+
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522
585
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const shortenExpressionSheetName = (name) => {
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523
586
|
return (name.length > MAX_NUM_CHARACTERS_DROPDOWN) ?
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587
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(name.slice(0, MAX_NUM_CHARACTERS_DROPDOWN) + "...") : name;
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@@ -628,7 +691,7 @@ const resetDatasetDropdownMenus = (workbook) => {
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628
691
|
var createHTMLforDataset = function (name) {
|
|
629
692
|
return `
|
|
630
693
|
<li class=\"dataset-option node-coloring-menu\" value=\"${name}\">
|
|
631
|
-
<a>
|
|
694
|
+
<a data-expression=\"${name}\">
|
|
632
695
|
<span class=\"glyphicon\"></span>
|
|
633
696
|
${name}
|
|
634
697
|
</a>
|
|
@@ -716,7 +779,7 @@ if (!grnState.genePageData.identified) {
|
|
|
716
779
|
|
|
717
780
|
export const updateApp = grnState => {
|
|
718
781
|
if (grnState.newWorkbook) {
|
|
719
|
-
|
|
782
|
+
checkWorkbookModeSettings();
|
|
720
783
|
grnState.normalizationMax = max(grnState.workbook.positiveWeights.concat(grnState.workbook.negativeWeights));
|
|
721
784
|
displayworkbook(grnState.workbook, grnState.name);
|
|
722
785
|
expandLayoutSidebar();
|
|
@@ -813,6 +876,8 @@ export const updateApp = grnState => {
|
|
|
813
876
|
$(NODE_COLORING_TOGGLE_SIDEBAR).prop("checked", true);
|
|
814
877
|
$(LOG_FOLD_CHANGE_MAX_VALUE_CLASS).val(DEFAULT_MAX_LOG_FOLD_CHANGE);
|
|
815
878
|
$(NODE_COLORING_SIDEBAR_BODY).removeClass("hidden");
|
|
879
|
+
$(NODE_COLORING_MENU).removeClass("hidden");
|
|
880
|
+
$(NODE_COLORING_NAVBAR_OPTIONS).removeClass("hidden");
|
|
816
881
|
if (grnState.database.expressionDatasets.includes(grnState.nodeColoring.topDataset) &&
|
|
817
882
|
grnState.workbook.expression[grnState.nodeColoring.topDataset] === undefined) {
|
|
818
883
|
if ($(NODE_COLORING_TOGGLE_SIDEBAR).prop("checked")) {
|
|
@@ -871,6 +936,8 @@ export const updateApp = grnState => {
|
|
|
871
936
|
}
|
|
872
937
|
} else if (grnState.workbook !== null && !grnState.nodeColoring.nodeColoringEnabled) {
|
|
873
938
|
$(NODE_COLORING_SIDEBAR_BODY).addClass("hidden");
|
|
939
|
+
$(NODE_COLORING_MENU).addClass("disabled");
|
|
940
|
+
$(NODE_COLORING_NAVBAR_OPTIONS).addClass("hidden");
|
|
874
941
|
$(`${NODE_COLORING_TOGGLE_MENU} span`).removeClass("glyphicon-ok");
|
|
875
942
|
$(NODE_COLORING_TOGGLE_SIDEBAR).prop("checked", false);
|
|
876
943
|
}
|