@sjcrh/proteinpaint-client 2.221.0 → 2.222.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (849) hide show
  1. package/dist/2dmaf-QFXSYOYN.js +1362 -0
  2. package/dist/AggMatrixInput-7D4ZUYJK.js +402 -0
  3. package/dist/AggregateMatrix-NVSFZEW3.js +37 -0
  4. package/dist/AppHeader-5YJWBQP6.js +826 -0
  5. package/dist/BoxPlot-52WWBGKN.js +1229 -0
  6. package/dist/CorrelationVolcano-WS23O2JT.js +613 -0
  7. package/dist/Cuminc-5LJQYFEE.js +1217 -0
  8. package/dist/DE-Z5GBDXDU.js +85 -0
  9. package/dist/DEinput-3EAIVG5U.js +479 -0
  10. package/dist/DM-24NZPPS6.js +86 -0
  11. package/dist/DifferentialAnalysis-LRAPDIXB.js +236 -0
  12. package/dist/Disco-IDOTCKSD.js +3384 -0
  13. package/dist/Disco.UI-SLJKAA6N.js +239 -0
  14. package/dist/DmrPlot-5CRGQNM3.js +361 -0
  15. package/dist/GB-YCDIORF3.js +1388 -0
  16. package/dist/GSEA-IGWX3AG7.js +870 -0
  17. package/dist/GeneExpInput-PPOTCILZ.js +38 -0
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  37. package/dist/ProteomeInput-KB7YRARQ.js +610 -0
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  142. package/dist/dataDownload-WIPQU33P.js +326 -0
  143. package/dist/databrowser.ui-6L6Q72W4.js +421 -0
  144. package/dist/dictionary-4VZEPGW5.js +109 -0
  145. package/dist/dnaMethylation-LN6THRNZ.js +29 -0
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  147. package/dist/e2pca-EXFI4Q2Y.js +340 -0
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  152. package/dist/geneExpClustering-7JFY7TQT.js +240 -0
  153. package/dist/geneExpression-FOQOKD34.js +29 -0
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  161. package/dist/geneset-BH5MWNJQ.js +199 -0
  162. package/dist/genomeBrowser.spec-BFTGLRHG.js +272 -0
  163. package/dist/grin2-4AXUYJIL.js +66 -0
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  799. /package/dist/{snp.unit.spec-6EENK7GQ.js.map → snp.unit.spec-BJGWNSVR.js.map} +0 -0
  800. /package/dist/{snplocus-R4JA6TFT.js.map → snplocus-UOVS2GD6.js.map} +0 -0
  801. /package/dist/{snplst-SOWVHSXH.js.map → snplst-JFVP4NG2.js.map} +0 -0
  802. /package/dist/{spliceevent.a53ss.diagram-IRLCCVQZ.js.map → spliceevent.a53ss.diagram-ETXJX57W.js.map} +0 -0
  803. /package/dist/{spliceevent.exonskip.diagram-4KG7LE5D.js.map → spliceevent.exonskip.diagram-C4JCEOXQ.js.map} +0 -0
  804. /package/dist/{spliceevent.noeventdiagram-OWXAJJX7.js.map → spliceevent.noeventdiagram-4DD3Z4OM.js.map} +0 -0
  805. /package/dist/{ssGSEA-EMOKPLMP.js.map → ssGSEA-GOZOYROM.js.map} +0 -0
  806. /package/dist/{ssGSEA.unit.spec-KXQ7R5WH.js.map → ssGSEA.unit.spec-J4DPFU4D.js.map} +0 -0
  807. /package/dist/{stattable-H2G7MOZG.js.map → stattable-ICUZQHUF.js.map} +0 -0
  808. /package/dist/{studyCatalog-3ITQXWFL.js.map → studyCatalog-PCFXVOI3.js.map} +0 -0
  809. /package/dist/{summarizeCnvGeneexp-ZIPU6YDY.js.map → summarizeCnvGeneexp-DK6HNUFE.js.map} +0 -0
  810. /package/dist/{summarizeGeneexpSurvival-3RYU226R.js.map → summarizeGeneexpSurvival-JLCR2VIX.js.map} +0 -0
  811. /package/dist/{summarizeMutationCnv-RGDBUB22.js.map → summarizeMutationCnv-CFAKT6IP.js.map} +0 -0
  812. /package/dist/{summarizeMutationDiagnosis-Z4MZE6Y4.js.map → summarizeMutationDiagnosis-5HMVSYMI.js.map} +0 -0
  813. /package/dist/{summarizeMutationSurvival-Z5CNRH7E.js.map → summarizeMutationSurvival-GP2OQMUS.js.map} +0 -0
  814. /package/dist/{summary-6QQCNX3B.js.map → summary-6K553VNS.js.map} +0 -0
  815. /package/dist/{summary.integration.spec-3ULXTZUP.js.map → summary.integration.spec-MXERZOVY.js.map} +0 -0
  816. /package/dist/{summaryInput-4QKR34QB.js.map → summaryInput-V2G6HFJS.js.map} +0 -0
  817. /package/dist/{sunburst-KB3BWC72.js.map → sunburst-6GKVNIRF.js.map} +0 -0
  818. /package/dist/{sunburst-XTFBHZNH.js.map → sunburst-YOVKC5G2.js.map} +0 -0
  819. /package/dist/{survival-NNCY4K6C.js.map → survival-GHTV2ZPX.js.map} +0 -0
  820. /package/dist/{survival-7O6ZK63E.js.map → survival-KF2QUWSM.js.map} +0 -0
  821. /package/dist/{survival.integration.spec-ZYZHZAXA.js.map → survival.integration.spec-GVSQL4VB.js.map} +0 -0
  822. /package/dist/{svgraph-ZLSFFEAC.js.map → svgraph-WN3JLEOC.js.map} +0 -0
  823. /package/dist/{svmr-REBBDEYM.js.map → svmr-ZZKBQFQK.js.map} +0 -0
  824. /package/dist/{swimmer-NUBRIWLI.js.map → swimmer-XHORJEVI.js.map} +0 -0
  825. /package/dist/{table-CWIQQESJ.js.map → table-XQCTNHSZ.js.map} +0 -0
  826. /package/dist/{termCollection-7TYJSQ45.js.map → termCollection-DXZQT7YT.js.map} +0 -0
  827. /package/dist/{termCollection-7Z55QNL7.js.map → termCollection-HRM2NHLA.js.map} +0 -0
  828. /package/dist/{termCollection.unit.spec-LQ5MIBDH.js.map → termCollection.unit.spec-BGULSLH6.js.map} +0 -0
  829. /package/dist/{termCollectionFractionSelection-24DZYVDU.js.map → termCollectionFractionSelection-TPNNP2ER.js.map} +0 -0
  830. /package/dist/{termCollectionFractionSelection.unit.spec-DCV2CFS5.js.map → termCollectionFractionSelection.unit.spec-VONXAGZH.js.map} +0 -0
  831. /package/dist/{tk-QTLEYIP7.js.map → tk-KPD6HTHR.js.map} +0 -0
  832. /package/dist/{tk-2WZFPRCP.js.map → tk-RCTQPQH7.js.map} +0 -0
  833. /package/dist/{tp.ui-HXQX2UH4.js.map → tp.ui-MVNQLMAD.js.map} +0 -0
  834. /package/dist/{tvs.categorical-4D3JI2ER.js.map → tvs.categorical-4TKKU6HO.js.map} +0 -0
  835. /package/dist/{tvs.condition-62FXFHZ5.js.map → tvs.condition-SARY3O5Y.js.map} +0 -0
  836. /package/dist/{tvs.dt-FZSVMJOO.js.map → tvs.dt-XJ2MW2AP.js.map} +0 -0
  837. /package/dist/{tvs.dtcnv.categorical-PPFQIC42.js.map → tvs.dtcnv.categorical-H7FKTXH4.js.map} +0 -0
  838. /package/dist/{tvs.dtcnv.continuous-TV2IGHY4.js.map → tvs.dtcnv.continuous-JQ62ZHER.js.map} +0 -0
  839. /package/dist/{tvs.dtfusion-ON4BA4XJ.js.map → tvs.dtfusion-GC3DZ2BO.js.map} +0 -0
  840. /package/dist/{tvs.dtitd-VFNROOWQ.js.map → tvs.dtitd-3SHGIDIB.js.map} +0 -0
  841. /package/dist/{tvs.dtsnvindel-ZXOP37T5.js.map → tvs.dtsnvindel-BEDWZ4A2.js.map} +0 -0
  842. /package/dist/{tvs.dtsv-EUHPTW7J.js.map → tvs.dtsv-HRIMULVD.js.map} +0 -0
  843. /package/dist/{tvs.multivalue-NHVXZNDI.js.map → tvs.multivalue-5VC7BLSZ.js.map} +0 -0
  844. /package/dist/{tvs.numeric-FPWDPO3J.js.map → tvs.numeric-TGEC7G6A.js.map} +0 -0
  845. /package/dist/{tvs.samplelst-ZZHRNUP4.js.map → tvs.samplelst-Q6EYAUQZ.js.map} +0 -0
  846. /package/dist/{tvs.survival-F3KSG3U6.js.map → tvs.survival-NJ3DTZIG.js.map} +0 -0
  847. /package/dist/{tvs.termCollection-B37DZLDY.js.map → tvs.termCollection-TVVLPSTG.js.map} +0 -0
  848. /package/dist/{vocabulary-XNE5FFDK.js.map → vocabulary-A7ZBBU65.js.map} +0 -0
  849. /package/dist/{wsi.direct-3YH3QGQD.js.map → wsi.direct-JJGIAH6A.js.map} +0 -0
@@ -1,848 +0,0 @@
1
- import {
2
- PlotBase,
3
- getBrainImagingSampleSet,
4
- sayerror
5
- } from "./chunk-WD7FZ5EE.js";
6
- import {
7
- Menu
8
- } from "./chunk-CNFTQSNE.js";
9
- import {
10
- DEFAULT_SAMPLE_TYPE,
11
- ROOT_SAMPLE_TYPE,
12
- getDateStrFromNumber,
13
- isNumericTerm
14
- } from "./chunk-JHLF2ZC2.js";
15
- import {
16
- copyMerge,
17
- getCompInit
18
- } from "./chunk-HBNB5TRH.js";
19
- import {
20
- select_default
21
- } from "./chunk-I6Y4O3RR.js";
22
-
23
- // plots/sampleView.ts
24
- var root_ID = "root";
25
- var samplesLimit = 15;
26
- var SampleView = class _SampleView extends PlotBase {
27
- static {
28
- this.type = "sampleView";
29
- }
30
- constructor(opts, api) {
31
- super(opts, api);
32
- this.type = _SampleView.type;
33
- this.setDom(opts);
34
- setInteractivity(this);
35
- setRenderers(this);
36
- }
37
- setDom(opts) {
38
- opts.holder.style("position", "relative");
39
- const div = opts.holder.append("div");
40
- const controlsDiv = div.append("div").style("display", "inline-block");
41
- const headerDiv = div.append("div").style("display", "inline-block").style("padding", "20px");
42
- const contentDiv = div.append("div").style("display", "flex").style("flex-direction", "row").style("flex-wrap", "wrap").style("justify-content", "flex-start").style("width", "100vw");
43
- const plotsDiv = contentDiv;
44
- const sampleDiv = headerDiv.insert("div").style("display", "inline-block");
45
- const showPlotsDiv = headerDiv.append("div").style("display", "inline-block").style("vertical-align", "top");
46
- const loadingDiv = opts.holder.append("div").attr("class", "sjpp-loading-overlay").style("display", "none");
47
- loadingDiv.append("div").attr("class", "sjpp-spinner");
48
- this.dom = {
49
- header: opts.header,
50
- holder: opts.holder,
51
- controlsDiv,
52
- sampleDiv,
53
- showPlotsDiv,
54
- loadingDiv,
55
- plotsDiv
56
- };
57
- }
58
- async init(appState) {
59
- this.termsByCohort = {};
60
- await this.setSampleSelect(appState);
61
- const state = this.getState(appState);
62
- await this.setControls(state);
63
- }
64
- async setSampleSelect(appState) {
65
- const config = appState.plots.find((p) => p.id === this.id);
66
- const sampleDiv = this.dom.sampleDiv;
67
- if (this.dom.header) this.dom.header.html(`Sample View`);
68
- if (config.samples && config.samples.length > 1) {
69
- const select = sampleDiv.insert("select").style("margin", "0px 5px").property("multiple", true).attr("id", "select");
70
- select.selectAll("option").data(config.samples).enter().append("option").attr("value", (d) => d.sampleId).property("selected", (d, _i) => _i < samplesLimit).text((d) => d.sampleName);
71
- this.dom.noteDiv = sampleDiv.insert("div").style("display", "none").style("vertical-align", "top").style("font-size", "0.8em").style("color", "#aaa").html(
72
- `*Note that only ${samplesLimit} samples can be selected.<br/>&nbsp;Navigate through the list to view all the samples.`
73
- );
74
- if (config.samples.length > samplesLimit) this.dom.noteDiv.style("display", "inline-block");
75
- select.on("change", () => {
76
- const options = select.node().options;
77
- const samples = [];
78
- let count = 0;
79
- for (const option of options) {
80
- if (option.selected) {
81
- if (count < samplesLimit) {
82
- const sampleId = Number(option.value);
83
- const sampleName = config.samples.find((s) => s.sampleId == sampleId).sampleName;
84
- const sample = { sampleId, sampleName };
85
- samples.push(sample);
86
- count++;
87
- } else option.selected = false;
88
- }
89
- }
90
- this.app.dispatch({ type: "plot_edit", id: this.id, config: { samples } });
91
- });
92
- } else {
93
- this.samplesData = await this.vocabApi.getSamplesByName({
94
- filter: appState.termfilter?.filter
95
- });
96
- if (Object.keys(this.samplesData).length == 0) throw "No accessible samples found";
97
- const callback = (sampleName2) => {
98
- if (this.samplesData[sampleName2]) {
99
- const samples = getSamplesRelated(this.samplesData, sampleName2, null, void 0);
100
- this.app.dispatch({ type: "plot_edit", id: this.id, config: { samples } });
101
- this.dom.downloadbt.property("disabled", false);
102
- } else {
103
- this.dom.tableDiv.style("display", "none");
104
- for (const div of this.discoPlots) div.cellDiv.style("display", "none");
105
- for (const div of Object.values(this.singleSamplePlots)) {
106
- div.forEach((p) => p.cellDiv.style("display", "none"));
107
- }
108
- for (const div of this.brainPlots) div.cellDiv.style("display", "none");
109
- this.swimmerDiv?.style("display", "none");
110
- if (sampleName2 != "") {
111
- this.dom.downloadbt.property("disabled", true);
112
- const errorDiv = sampleDiv.append("div");
113
- sayerror(errorDiv, `Invalid sample ID: ${sampleName2}. Please check the sample ID.`);
114
- setTimeout(() => {
115
- errorDiv.remove();
116
- }, 6e3);
117
- }
118
- }
119
- };
120
- const hasSampleAncestry = appState.termdbConfig.hasSampleAncestry;
121
- const sampleName = searchSampleInput(this.dom.sampleDiv, this.samplesData, hasSampleAncestry, callback, void 0);
122
- this.sample = config.sample || { sampleId: this.samplesData[sampleName].id, sampleName };
123
- if (config.sample?.sampleName) sampleDiv.select("input").property("value", config.sample.sampleName);
124
- this.dom.downloadbt = sampleDiv.insert("button").style("margin-left", "10px").style("vertical-align", "top").text("Download").on("click", () => {
125
- this.downloadData();
126
- });
127
- this.dom.messageDiv = sampleDiv.insert("div").style("display", "inline-block").style("display", "none").style("vertical-align", "top").html("&nbsp;&nbsp;Downloading data ...");
128
- }
129
- }
130
- getState(appState) {
131
- const config = appState.plots?.find((p) => p.id === this.id);
132
- let samples = config.samples || getSamplesRelated(this.samplesData, this.sample.sampleName, null, void 0);
133
- if (config.samples?.length > 15) samples = config.samples.filter((s, i) => i < 15);
134
- const q = appState.termdbConfig.queries;
135
- const state = {
136
- config,
137
- termfilter: appState.termfilter,
138
- // TODO: use state.config drectly, instead of having to extract
139
- // selected config.key-values into the component state
140
- activeCohort: config.activeCohort,
141
- terms: config.terms,
142
- expandedTermIds: config.expandedTermIds,
143
- samples,
144
- singleSampleGenomeQuantification: q?.singleSampleGenomeQuantification,
145
- singleSampleMutation: q?.singleSampleMutation,
146
- NIdata: q?.NIdata,
147
- hasVerifiedToken: this.app.vocabApi.hasVerifiedToken(),
148
- tokenVerificationPayload: this.app.vocabApi.tokenVerificationPayload,
149
- termdbConfig: appState.termdbConfig,
150
- vocab: appState.vocab
151
- };
152
- if (appState.termdbConfig.selectCohort) {
153
- state.toSelectCohort = true;
154
- const choice = appState.termdbConfig.selectCohort.values[state.activeCohort];
155
- if (choice) {
156
- state.cohortValuelst = choice.keys;
157
- }
158
- }
159
- return state;
160
- }
161
- async main() {
162
- if (this.mayRequireToken()) return;
163
- this.dom.loadingDiv.style("display", "");
164
- try {
165
- this.config = structuredClone(this.state.config);
166
- this.settings = this.state.config.settings.sampleView;
167
- this.dom.plotsDiv.selectAll("*").remove();
168
- this.termsById = this.getTermsById(this.state);
169
- this.sampleDataByTermId = {};
170
- const root = this.termsById[root_ID];
171
- root.terms = await this.requestTermRecursive(root);
172
- this.orderedVisibleTerms = this.getOrderedVisibleTerms(root);
173
- if (this.dom.downloadbt)
174
- this.dom.downloadbt.style("display", this.settings.showDictionary ? "inline-block" : "none");
175
- if (this.settings.showDictionary) this.renderSampleDictionary();
176
- this.dom.tableDiv.style("display", this.settings.showDictionary ? "block" : "none");
177
- await this.renderPlots(this.state, this.state.samples);
178
- this.showVisiblePlots();
179
- } finally {
180
- this.dom.loadingDiv.style("display", "none");
181
- }
182
- }
183
- async setControls(state) {
184
- const q = state.termdbConfig.queries;
185
- const hasPlots = q?.singleSampleMutation || q?.singleSampleGenomeQuantification || q?.NIdata || q?.images || q?.swimmer;
186
- if (hasPlots) {
187
- this.dom.showPlotsDiv.append("input").attr("id", "showDictionary").attr("type", "checkbox").property("checked", true).on("change", (e) => {
188
- this.app.dispatch({
189
- type: "plot_edit",
190
- id: this.id,
191
- config: { settings: { sampleView: { showDictionary: e.target.checked } } }
192
- });
193
- });
194
- this.dom.showPlotsDiv.append("label").text("Show Dictionary").attr("for", "showDictionary");
195
- }
196
- if (q?.singleSampleMutation) {
197
- this.dom.showPlotsDiv.append("input").attr("type", "checkbox").property("checked", true).attr("id", "showDisco").on("change", (e) => {
198
- this.app.dispatch({
199
- type: "plot_edit",
200
- id: this.id,
201
- config: { settings: { sampleView: { showDisco: e.target.checked } } }
202
- });
203
- });
204
- this.dom.showPlotsDiv.append("label").text("Show Disco").attr("for", "showDisco");
205
- }
206
- if (q?.singleSampleGenomeQuantification) {
207
- for (const ssgqKey in q.singleSampleGenomeQuantification) {
208
- const label = ssgqKey.replace(/([a-z](?=[A-Z]))/g, "$1 ");
209
- this.dom.showPlotsDiv.append("input").attr("type", "checkbox").property("checked", true).attr("id", ssgqKey).on("change", (e) => {
210
- this.app.dispatch({
211
- type: "plot_edit",
212
- id: this.id,
213
- config: { settings: { sampleView: { [ssgqKey]: e.target.checked } } }
214
- });
215
- });
216
- this.dom.showPlotsDiv.append("label").text("Show " + label).attr("for", ssgqKey);
217
- }
218
- }
219
- if (q?.images) {
220
- this.dom.showPlotsDiv.append("input").attr("type", "checkbox").property("checked", true).attr("id", "showImages").on("change", (e) => {
221
- this.app.dispatch({
222
- type: "plot_edit",
223
- id: this.id,
224
- config: { settings: { sampleView: { showImages: e.target.checked } } }
225
- });
226
- });
227
- this.dom.showPlotsDiv.append("label").text("Show Images").attr("for", "showImages");
228
- }
229
- if (q?.NIdata) {
230
- this.dom.showPlotsDiv.append("input").attr("type", "checkbox").property("checked", true).attr("id", "showBrainImaging").on("change", (e) => {
231
- this.app.dispatch({
232
- type: "plot_edit",
233
- id: this.id,
234
- config: { settings: { sampleView: { showBrainImaging: e.target.checked } } }
235
- });
236
- });
237
- this.dom.showPlotsDiv.append("label").text("Show brain imaging").attr("for", "showBrainImaging");
238
- }
239
- if (q?.swimmer) {
240
- this.dom.showPlotsDiv.append("input").attr("type", "checkbox").property("checked", true).attr("id", "showSwimmer").on("change", (e) => {
241
- this.app.dispatch({
242
- type: "plot_edit",
243
- id: this.id,
244
- config: { settings: { sampleView: { showSwimmer: e.target.checked } } }
245
- });
246
- });
247
- this.dom.showPlotsDiv.append("label").text("Show swimmer plot").attr("for", "showSwimmer");
248
- }
249
- }
250
- getTermsById(state) {
251
- if (!(state.activeCohort in this.termsByCohort)) {
252
- this.termsByCohort[state.activeCohort] = {
253
- [root_ID]: {
254
- id: root_ID,
255
- __tree_isroot: true
256
- // must not delete this flag
257
- }
258
- };
259
- }
260
- return this.termsByCohort[state.activeCohort];
261
- }
262
- async requestTermRecursive(term, _ancestry = [root_ID]) {
263
- const data = await this.vocabApi.getTermChildren(
264
- term,
265
- this.state.toSelectCohort ? this.state.cohortValuelst : null,
266
- this.state.termfilter.filter
267
- );
268
- if (data.error) throw data.error;
269
- if (!data.lst || data.lst.length == 0) {
270
- return [];
271
- }
272
- const terms = [];
273
- const parent_id = _ancestry.slice(-1)[0];
274
- for (const t of data.lst) {
275
- t.parent_id = parent_id;
276
- const ancestry = [..._ancestry];
277
- const copy = structuredClone(t);
278
- copy.ancestry = ancestry;
279
- terms.push(copy);
280
- if (!copy.isleaf && this.config.expandedTermIds.includes(copy.id)) {
281
- copy.terms = await this.requestTermRecursive(copy, [...ancestry, t.id]);
282
- if (this.state.samples) await this.fillSampleData(copy.terms);
283
- } else {
284
- const t0 = this.termsById[copy.id];
285
- if (this.state.samples) await this.fillSampleData([copy]);
286
- if (t0 && t0.terms) {
287
- copy.terms = t0.terms;
288
- }
289
- }
290
- this.termsById[copy.id] = copy;
291
- }
292
- return terms;
293
- }
294
- getOrderedVisibleTerms(_root) {
295
- const visibleTerms = Object.values(this.termsById).filter(this.isVisibleTermId.bind(this));
296
- const orderedVisibleTerms = [];
297
- this.sortVisibleTerms(this.termsById[root_ID], visibleTerms, orderedVisibleTerms);
298
- return orderedVisibleTerms;
299
- }
300
- isVisibleTermId(term) {
301
- if (term.parent_id == root_ID) return true;
302
- if (!term.ancestry) return false;
303
- for (const pid of term.ancestry) {
304
- if (pid === root_ID) continue;
305
- if (!this.config.expandedTermIds.includes(pid)) return false;
306
- }
307
- return true;
308
- }
309
- sortVisibleTerms(currParent, remainingTerms, currOrder = []) {
310
- const unorderedTerms = [];
311
- const orderedTerms = [];
312
- for (const term of remainingTerms) {
313
- if (term.parent_id == currParent.id) {
314
- orderedTerms.push(term);
315
- } else unorderedTerms.push(term);
316
- }
317
- remainingTerms.splice(0, remainingTerms.length, ...unorderedTerms);
318
- if (remainingTerms.length) {
319
- for (const term of orderedTerms) {
320
- currOrder.push(term);
321
- if (!term.isleaf && remainingTerms.length) {
322
- this.sortVisibleTerms(term, remainingTerms, currOrder);
323
- }
324
- }
325
- } else {
326
- currOrder.push(...orderedTerms);
327
- }
328
- }
329
- async fillSampleData(terms) {
330
- const term_ids = [];
331
- for (const term of terms) term_ids.push(term.id);
332
- for (const sample of this.state.samples) {
333
- const data = await this.vocabApi.getSingleSampleData({
334
- sampleId: sample.sampleId,
335
- term_ids,
336
- filter: this.state.termfilter.filter
337
- });
338
- if ("error" in data) throw data.error;
339
- if (!this.sampleDataByTermId[sample.sampleId]) this.sampleDataByTermId[sample.sampleId] = {};
340
- for (const id in data) this.sampleDataByTermId[sample.sampleId][id] = data[id];
341
- }
342
- }
343
- async downloadData() {
344
- this.dom.messageDiv.style("display", "block");
345
- this.dom.downloadbt.style("display", "none");
346
- const filename = `samples.tsv`;
347
- const sampleData = {};
348
- let lines = "Sample";
349
- for (const sample of this.state.samples) {
350
- sampleData[sample.sampleId] = await this.vocabApi.getSingleSampleData({
351
- sampleId: sample.sampleId,
352
- /** term_ids is required for getSingleSampleData but not
353
- * available in this instance. Pass empty array.*/
354
- term_ids: [],
355
- filter: this.state.termfilter.filter || []
356
- });
357
- lines += ` ${sample.sampleName}`;
358
- }
359
- lines += "\n";
360
- const sampleId = this.state.samples[0].sampleId;
361
- for (const termId in sampleData[sampleId]) {
362
- const term = sampleData[sampleId][termId].term;
363
- lines += `${term.name}`;
364
- for (const sampleId2 in sampleData) {
365
- const data = sampleData[sampleId2];
366
- let value = getTermValue(term, data);
367
- if (value == null) value = "Missing";
368
- lines += ` ${value}`;
369
- }
370
- lines += "\n";
371
- }
372
- const dataStr = "data:text/tsv;charset=utf-8," + encodeURIComponent(lines);
373
- const link = document.createElement("a");
374
- link.setAttribute("href", dataStr);
375
- link.setAttribute("download", filename);
376
- document.body.appendChild(link);
377
- link.click();
378
- link.remove();
379
- this.dom.messageDiv.style("display", "none");
380
- this.dom.downloadbt.style("display", "inline-block");
381
- }
382
- mayRequireToken() {
383
- if (this.state.hasVerifiedToken) {
384
- this.dom.holder.style("display", "block");
385
- return false;
386
- } else {
387
- const e = this.state.tokenVerificationPayload;
388
- const missingAccess = e?.error == "Missing access" && this.state.termdbConfig.dataDownloadCatch?.missingAccess;
389
- const message = missingAccess?.message?.replace("MISSING-ACCESS-LINK", missingAccess?.links[e?.linkKey]);
390
- const helpLink = this.state.termdbConfig.dataDownloadCatch?.helpLink;
391
- this.dom.holder.style("color", "#e44").style("padding", "10px").html(
392
- message || (this.state.tokenVerificationMessage || "Requires sign-in") + (helpLink ? ` <a href='${helpLink}' target=_blank>Tutorial</a>` : "")
393
- );
394
- return true;
395
- }
396
- }
397
- showVisiblePlots() {
398
- this.visiblePlots = false;
399
- this.showPlotsFromCategory(this.discoPlots, "showDisco");
400
- for (const ssgqKey in this.state.singleSampleGenomeQuantification)
401
- this.showPlotsFromCategory(this.singleSamplePlots[ssgqKey], ssgqKey);
402
- this.showPlotsFromCategory(this.brainPlots, "showBrain");
403
- this.showPlotsFromCategory(this.imagePlots, "showImages");
404
- if (this.swimmerDiv) {
405
- this.swimmerDiv.style("display", this.settings.showSwimmer ? "block" : "none");
406
- if (this.settings.showSwimmer) this.visiblePlots = true;
407
- }
408
- if (this.state.samples.length == 1 && this.visiblePlots)
409
- this.dom.tableDiv.style("max-width", "48vw").style("max-height", "40vw").attr("class", "sjpp_show_scrollbar");
410
- else this.dom.tableDiv.style("max-width", "").style("max-height", "").attr("class", "");
411
- }
412
- showPlotsFromCategory(plots, key) {
413
- for (const div of plots) {
414
- const visibleSample = this.state.samples.find((s) => s.sampleName == div.sample.sampleName);
415
- const visiblePlot = this.settings[key] && visibleSample;
416
- if (visiblePlot) this.visiblePlots = true;
417
- div.cellDiv.style("display", visiblePlot ? "table-cell" : "none");
418
- }
419
- }
420
- async renderPlots(state, samples) {
421
- const plotsDiv = this.dom.plotsDiv;
422
- this.discoPlots = [];
423
- this.singleSamplePlots = {};
424
- this.brainPlots = [];
425
- this.imagePlots = [];
426
- delete this.swimmerDiv;
427
- this.swimmerRenderer?.destroy();
428
- delete this.swimmerRenderer;
429
- if (state.termdbConfig?.queries?.singleSampleMutation) {
430
- const div = plotsDiv.append("div");
431
- if (state.samples.length == 1) div.style("display", "inline-block").style("width", "50vw");
432
- let someFound = false;
433
- for (const sample of samples) {
434
- const cellDiv = div.append("div").style("display", "inline-block");
435
- this.discoPlots.push({ sample, cellDiv });
436
- const header = cellDiv.insert("div");
437
- const discoPlotImport = await import("./plot.disco-3MSCX7TM.js");
438
- const found = await discoPlotImport.default(
439
- state.termdbConfig,
440
- state.vocab.dslabel,
441
- { sample_id: sample.sampleName },
442
- cellDiv,
443
- this.app.opts.genome,
444
- {},
445
- //overrides
446
- false
447
- //showError
448
- );
449
- if (found) {
450
- if (state.samples.length > 1)
451
- header.style("font-weight", "bold").style("padding-left", "20px").text(sample.sampleName);
452
- someFound = true;
453
- }
454
- }
455
- this.dom.showPlotsDiv.select("input[id=showDisco").style("display", someFound ? "inline-block" : "none");
456
- this.dom.showPlotsDiv.select("label[for=showDisco").style("display", someFound ? "inline-block" : "none");
457
- }
458
- if (state.termdbConfig.queries?.singleSampleGenomeQuantification) {
459
- for (const k in state.termdbConfig.queries.singleSampleGenomeQuantification) {
460
- let someFound = false;
461
- this.singleSamplePlots[k] = [];
462
- const div = plotsDiv.append("div");
463
- if (state.samples.length == 1) div.style("display", "inline-block").style("width", "50vw");
464
- for (const sample of samples) {
465
- const label = (k.match(/[A-Z][a-z]+|[0-9]+/g) || []).join(" ");
466
- const plotDiv = div.insert("div").style("display", "table-cell").style("padding", "20px");
467
- this.singleSamplePlots[k].push({ sample, cellDiv: plotDiv });
468
- if (state.samples.length > 1)
469
- plotDiv.insert("div").style("font-weight", "bold").text(`${sample.sampleName} ${label}`);
470
- const ssgqImport = await import("./plot.ssgq-4KBVHF42.js");
471
- const found = await ssgqImport.plotSingleSampleGenomeQuantification(
472
- state.termdbConfig,
473
- state.vocab.dslabel,
474
- k,
475
- { sample_id: sample.sampleName },
476
- plotDiv.insert("div"),
477
- this.app.opts.genome,
478
- null,
479
- //geneName
480
- false
481
- //showError
482
- );
483
- if (found) someFound = true;
484
- }
485
- this.dom.showPlotsDiv.select(`input[id=${k}`).style("display", someFound ? "inline-block" : "none");
486
- this.dom.showPlotsDiv.select(`label[for=${k}`).style("display", someFound ? "inline-block" : "none");
487
- }
488
- }
489
- if (state.termdbConfig.queries?.NIdata) {
490
- const k = Object.keys(state.termdbConfig.queries.NIdata.references)[0];
491
- let available = /* @__PURE__ */ new Set();
492
- try {
493
- available = k ? await getBrainImagingSampleSet(state.vocab.genome, state.vocab.dslabel, k) : /* @__PURE__ */ new Set();
494
- } catch (e) {
495
- console.error("brainImagingSamples request failed:", e);
496
- }
497
- const samplesWithImaging = samples.filter((s) => available.has(s.sampleName));
498
- if (samplesWithImaging.length) {
499
- const div = plotsDiv.append("div");
500
- if (state.samples.length == 1) div.style("display", "inline-block").style("width", "50vw");
501
- for (const sample of samplesWithImaging) {
502
- const plotDiv = div.insert("div").style("display", "inline-block");
503
- this.brainPlots.push({ sample, cellDiv: plotDiv });
504
- if (state.samples.length > 1)
505
- plotDiv.insert("div").style("font-weight", "bold").style("padding-left", "20px").text(sample.sampleName);
506
- const brainImagingImport = await import("./plot.brainImaging-UTHFJFXU.js");
507
- brainImagingImport.default(
508
- state.termdbConfig,
509
- state.vocab.dslabel,
510
- k,
511
- { sample_id: sample.sampleName },
512
- plotDiv,
513
- this.app.opts.genome
514
- );
515
- }
516
- }
517
- }
518
- if (state.termdbConfig?.queries?.images) {
519
- const div = plotsDiv.append("div");
520
- if (state.samples.length == 1) div.style("display", "inline-block").style("width", "50vw");
521
- for (const sample of samples) {
522
- const cellDiv = div.append("div").style("display", "inline-block");
523
- this.imagePlots.push({ sample, cellDiv });
524
- if (state.samples.length > 1)
525
- cellDiv.insert("div").style("font-weight", "bold").style("padding-left", "20px").text(sample.sampleName);
526
- const imagePlotImport = await import("./imagePlot-KBRXDV5G.js");
527
- imagePlotImport.renderImagePlot(state, cellDiv, sample);
528
- }
529
- }
530
- if (state.termdbConfig?.queries?.swimmer) await this.renderSwimmer(state, samples);
531
- }
532
- /** the swimmer lane of the shown samples' patient (found from any sample of the patient), drawn once
533
- below the other plots. the checkbox is hidden when there is no lane */
534
- async renderSwimmer(state, samples) {
535
- if (!samples.length) return;
536
- const { fetchSwimmerLanes, SwimmerRenderer, getDefaultSwimmerSettings } = await import("./swimmer-NUBRIWLI.js");
537
- let lanes = [];
538
- let timeReference;
539
- try {
540
- const result = await fetchSwimmerLanes({
541
- genome: state.vocab.genome,
542
- dslabel: state.vocab.dslabel,
543
- samples: samples.map((s) => s.sampleName),
544
- // set when opened from a swimmer plot, to show the same time reference; unset: the ds default
545
- timeReference: state.config.swimmerTimeReference
546
- });
547
- lanes = result.lanes;
548
- timeReference = result.timeReference;
549
- } catch (e) {
550
- console.error("swimmer request failed:", e);
551
- }
552
- this.dom.showPlotsDiv.select("input[id=showSwimmer]").style("display", lanes.length ? "inline-block" : "none");
553
- this.dom.showPlotsDiv.select("label[for=showSwimmer]").style("display", lanes.length ? "inline-block" : "none");
554
- if (!lanes.length) return;
555
- const div = this.dom.plotsDiv.append("div").attr("data-testid", "sjpp-sampleview-swimmer").style("width", "100%");
556
- this.swimmerDiv = div;
557
- div.append("div").style("font-weight", "bold").style("padding", "10px 20px 0 20px").text("Swimmer plot");
558
- const renderer = new SwimmerRenderer(this.app, {
559
- plotDiv: div.append("div").style("padding", "10px"),
560
- noteDiv: div.append("div").style("padding", "0 20px").style("font-size", ".9em").style("opacity", 0.7),
561
- tip: new Menu({ padding: "5px" })
562
- });
563
- this.swimmerRenderer = renderer;
564
- renderer.update({
565
- swimmer: state.termdbConfig.queries.swimmer,
566
- settings: getDefaultSwimmerSettings(),
567
- lanes,
568
- timeReference
569
- });
570
- }
571
- destroy() {
572
- this.swimmerRenderer?.destroy();
573
- }
574
- };
575
- function getTermValue(term, data) {
576
- let value = data[term.id]?.value;
577
- if (value == null || value == void 0 || value == "undefined") return null;
578
- if (term.type == "date") return getDateStrFromNumber(value);
579
- if (isNumericTerm(term)) {
580
- value = term.values?.[value]?.label || term.values?.[value]?.key || value;
581
- if (isNaN(value)) return value;
582
- return value % 1 == 0 ? value.toString() : value.toFixed(2).toString();
583
- }
584
- if (term.type == "categorical") return term.values[value]?.label || term.values[value]?.key;
585
- if (term.type == "condition") {
586
- const values = value.toString().split(" ");
587
- const [years, statusKey] = values;
588
- const status = term.values[statusKey].label || term.values[statusKey].key;
589
- return `Max grade: ${status}, Time to event: ${Number(years).toFixed(1)} years`;
590
- }
591
- if (term.type == "survival") {
592
- const values = value.split(" ");
593
- const [years, statusKey] = values;
594
- const status = term.values?.[statusKey]?.label || term.values?.[statusKey]?.key || statusKey;
595
- return `${status} after ${Number(years).toFixed(1)} years`;
596
- }
597
- return null;
598
- }
599
- var sampleViewInit = getCompInit(SampleView);
600
- var componentInit = sampleViewInit;
601
- function setRenderers(self) {
602
- self.renderSampleDictionary = function() {
603
- this.dom.tableDiv = this.dom.plotsDiv.append("div").style("display", "inline-block").style("padding", "20px");
604
- const table = this.dom.tableDiv.append("table").style("border-collapse", "collapse");
605
- const thead = table.append("thead");
606
- const theadrow = thead.append("tr");
607
- const tbody = table.append("tbody");
608
- const visibleSamples = [];
609
- for (const sample of self.state.samples) visibleSamples.push(self.sampleDataByTermId[sample.sampleId]);
610
- self.renderTHead(["", ...self.state.samples.map((s) => s.sampleName)], theadrow);
611
- const tBodyData = self.orderedVisibleTerms.map((term, _trIndex) => [
612
- { term },
613
- // first column, no sample data
614
- // create data to bind for each sample column
615
- ...visibleSamples.map((sample) => ({ term, sample }))
616
- ]);
617
- self.renderTBody(tBodyData, tbody);
618
- };
619
- self.renderTHead = function(data, theadrow) {
620
- const trs = theadrow.selectAll("th").data(data);
621
- trs.exit().remove();
622
- trs.text(self.getThHtml);
623
- trs.enter().append("th").style("padding", "5px 10px").style("text-align", "end").text(self.getThHtml);
624
- };
625
- self.getThHtml = (d) => d;
626
- self.renderTBody = function(data, tbody) {
627
- const trs = tbody.selectAll("tr").data(data);
628
- trs.exit().remove();
629
- trs.each(self.renderTr);
630
- trs.enter().append("tr").each(self.renderTr);
631
- };
632
- self.renderTr = function(trData, _trIndex) {
633
- const tds = select_default(this).selectAll("td").data(trData, (d) => d);
634
- tds.exit().remove();
635
- tds.each(self.renderTd);
636
- tds.enter().append("td").style("border-bottom", "solid 1px rgb(245,245,245)").style("text-align", (d, _i) => _i === 0 ? "left" : "center").style("padding", "2px 10px").each(self.renderTd);
637
- };
638
- self.renderTd = function(d, _i) {
639
- if (!d.sample) {
640
- self.renderTerm(select_default(this));
641
- return;
642
- }
643
- const term = d.term;
644
- const isNumeric = isNumericTerm(term);
645
- const value = getTermValue(d.term, d.sample);
646
- const td = select_default(this).datum(d).style("text-align", "end").style("padding", "5px 10px").text(d.sample[d.term.id]?.label || value);
647
- if (isNumeric)
648
- td.append("button").style("margin-left", "5px").text("Plot").on("click", () => {
649
- const tw = { id: term.id, q: { mode: "continuous" } };
650
- self.app.dispatch({ type: "plot_create", config: { chartType: "violin", term: tw, value } });
651
- });
652
- };
653
- self.renderTerm = function(td) {
654
- const d = td.datum();
655
- if (!td.select("span").size()) {
656
- const span2 = td.append("span");
657
- span2.append("button").style("border-width", 0).style("border-radius", "5px").style("width", "28px").style("height", "28px").style("cursor", "pointer");
658
- span2.append("span").style("margin-left", `3px`).style("cursor", "pointer");
659
- td.on("click", self.toggleTerm);
660
- }
661
- const leftIndent = (d.term.ancestry.length - 1) * 24;
662
- const span = td.select(":scope>span").style("margin-left", `${leftIndent}px`);
663
- span.select("button").style("display", d.term.isleaf ? "none" : "").html(self.config.expandedTermIds.includes(d.term.id) ? "-" : "+");
664
- span.select("span").text(d.term.name);
665
- return;
666
- };
667
- }
668
- function setInteractivity(self) {
669
- self.toggleTerm = function() {
670
- const d = select_default(this).datum();
671
- if (d.term.isleaf) return;
672
- const expandedTermIds = self.config.expandedTermIds.slice();
673
- const i = expandedTermIds.indexOf(d.term.id);
674
- if (i == -1) expandedTermIds.push(d.term.id);
675
- else expandedTermIds.splice(i, 1);
676
- self.app.dispatch({
677
- type: "plot_edit",
678
- id: self.id,
679
- config: { expandedTermIds }
680
- });
681
- };
682
- }
683
- async function getPlotConfig(opts, app) {
684
- const q = app.getState()?.termdbConfig?.queries;
685
- const settings = {
686
- sampleView: {
687
- showDictionary: true,
688
- showDisco: true,
689
- showBrain: true,
690
- showImages: true,
691
- showSwimmer: true
692
- }
693
- };
694
- if (q)
695
- for (const ssgqKey in q.singleSampleGenomeQuantification) settings.sampleView[ssgqKey] = true;
696
- const config = { activeCohort: 0, sample: null, expandedTermIds: [root_ID], settings, hidePlotFilter: true };
697
- return copyMerge(config, opts);
698
- }
699
- function searchSampleInput(holder, samplesData, hasSampleAncestry, callback, keyUpCallback) {
700
- const limit = 100;
701
- const allSamples = [];
702
- for (const sample in samplesData) {
703
- const sample_type = samplesData[sample].sample_type;
704
- if (sample_type == ROOT_SAMPLE_TYPE || sample_type == null || !hasSampleAncestry && sample_type == DEFAULT_SAMPLE_TYPE)
705
- allSamples.push(sample);
706
- }
707
- const isBigDataset = allSamples.length > 1e4;
708
- if (allSamples.length == 0)
709
- return;
710
- const { childrenByParent, rootFor } = buildHierarchy(samplesData);
711
- const sampleName = allSamples[0];
712
- const input = holder.append("input").attr("list", "sampleDatalist").property("autocomplete", "off").attr("placeholder", sampleName).style("width", "250px");
713
- holder.style("opacity", "0.8");
714
- const datalist = holder.append("datalist").attr("id", "sampleDatalist");
715
- addOptions(allSamples);
716
- input.on("keyup", () => {
717
- datalist.selectAll("*").remove();
718
- const str = input.node().value.toLowerCase();
719
- if (keyUpCallback) keyUpCallback(str);
720
- const options = [];
721
- for (const sample of allSamples) {
722
- if (sample.toLowerCase().startsWith(str)) options.push(sample);
723
- if (options.length == limit && allSamples.length > 1e4) break;
724
- }
725
- for (const sample of allSamples) {
726
- if (sample.toLowerCase().includes(str) && !options.includes(sample)) options.push(sample);
727
- if (options.length == limit && allSamples.length > 1e4) break;
728
- }
729
- if (options.length > 1 || options.length == 1 && input.node().value != options[0]) addOptions(options);
730
- });
731
- input.on("change", () => {
732
- const sampleName2 = input.node().value;
733
- callback(sampleName2);
734
- });
735
- function addOptions(options) {
736
- datalist.selectAll("option").data(options.filter((s, i) => i < limit)).enter().append("option").attr("value", (d) => d).attr(
737
- "label",
738
- (d, i) => getLabel(d, childrenByParent, rootFor) + (i + 1 == limit ? isBigDataset ? ` Showing first ${i + 1} hits` : ` Showing ${i + 1} of ${options.length} hits` : i + 1 === options.length && i > 0 ? ` (Found ${options.length} hits)` : "")
739
- );
740
- }
741
- function getLabel(sampleName2, childrenByParent2, rootFor2) {
742
- const rootName = rootFor2.get(sampleName2) || sampleName2;
743
- if (!childrenByParent2.has(rootName)) return sampleName2;
744
- const rootChildren = childrenByParent2.get(rootName) || [];
745
- if (rootChildren.length === 0) return sampleName2;
746
- const parts = [];
747
- for (const child of rootChildren) {
748
- const chain = [child];
749
- let cur = child;
750
- let kids = childrenByParent2.get(cur) || [];
751
- while (kids.length > 0) {
752
- chain.push(kids[0]);
753
- cur = kids[0];
754
- kids = childrenByParent2.get(cur) || [];
755
- }
756
- parts.push(chain.length > 1 ? chain.join(" > ") : child);
757
- }
758
- return parts.join(", ");
759
- }
760
- return sampleName;
761
- }
762
- function buildHierarchy(samplesData) {
763
- const childrenByParent = /* @__PURE__ */ new Map();
764
- const rootFor = /* @__PURE__ */ new Map();
765
- for (const s of Object.values(samplesData)) {
766
- const childName = s.name;
767
- const parentName = s.ancestor_name;
768
- if (parentName) {
769
- if (!childrenByParent.has(parentName)) {
770
- childrenByParent.set(parentName, []);
771
- }
772
- childrenByParent.get(parentName).push(childName);
773
- }
774
- let root = childName;
775
- let curr = s;
776
- while (curr?.ancestor_name) {
777
- root = curr.ancestor_name;
778
- curr = samplesData[root];
779
- }
780
- rootFor.set(childName, root);
781
- }
782
- for (const list of childrenByParent.values()) {
783
- list.sort((a, b) => {
784
- const na = Number(a);
785
- const nb = Number(b);
786
- return !isNaN(na) && !isNaN(nb) ? na - nb : a.localeCompare(b);
787
- });
788
- }
789
- return { childrenByParent, rootFor };
790
- }
791
- function getSamplesRelated(samplesData, sampleName, childrenByParent = null, rootFor) {
792
- if (!samplesData[sampleName]) return [];
793
- let rootName;
794
- if (rootFor && childrenByParent) {
795
- rootName = rootFor.get(sampleName);
796
- } else {
797
- rootName = sampleName;
798
- let current = samplesData[sampleName];
799
- while (current?.ancestor_name) {
800
- rootName = current.ancestor_name;
801
- current = samplesData[rootName];
802
- }
803
- }
804
- const root = samplesData[rootName];
805
- if (!root) return [];
806
- let kidsMap = childrenByParent;
807
- if (!kidsMap) {
808
- kidsMap = /* @__PURE__ */ new Map();
809
- for (const s of Object.values(samplesData)) {
810
- if (s.ancestor_name) {
811
- if (!kidsMap.has(s.ancestor_name)) kidsMap.set(s.ancestor_name, []);
812
- kidsMap.get(s.ancestor_name).push(s);
813
- }
814
- }
815
- for (const list of kidsMap.values()) {
816
- list.sort((a, b) => {
817
- const na = Number(a.name);
818
- const nb = Number(b.name);
819
- if (!isNaN(na) && !isNaN(nb)) return na - nb;
820
- return a.name.localeCompare(b.name);
821
- });
822
- }
823
- }
824
- const samples = [];
825
- const hasChildren = (kidsMap.get(rootName) || []).length > 0;
826
- if (root.sample_type !== ROOT_SAMPLE_TYPE || !hasChildren) {
827
- samples.push({ sampleId: root.id, sampleName: root.name });
828
- }
829
- function traverse(parentName) {
830
- const kids = kidsMap.get(parentName) || [];
831
- for (const kid of kids) {
832
- samples.push({ sampleId: kid.id, sampleName: kid.name });
833
- traverse(kid.name);
834
- }
835
- }
836
- traverse(rootName);
837
- return samples;
838
- }
839
-
840
- export {
841
- getTermValue,
842
- sampleViewInit,
843
- componentInit,
844
- getPlotConfig,
845
- searchSampleInput,
846
- getSamplesRelated
847
- };
848
- //# sourceMappingURL=chunk-IFPRYTS7.js.map