@sjcrh/proteinpaint-client 2.221.0 → 2.222.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/dist/2dmaf-QFXSYOYN.js +1362 -0
- package/dist/AggMatrixInput-7D4ZUYJK.js +402 -0
- package/dist/AggregateMatrix-NVSFZEW3.js +37 -0
- package/dist/AppHeader-5YJWBQP6.js +826 -0
- package/dist/BoxPlot-52WWBGKN.js +1229 -0
- package/dist/CorrelationVolcano-WS23O2JT.js +613 -0
- package/dist/Cuminc-5LJQYFEE.js +1217 -0
- package/dist/DE-Z5GBDXDU.js +85 -0
- package/dist/DEinput-3EAIVG5U.js +479 -0
- package/dist/DM-24NZPPS6.js +86 -0
- package/dist/DifferentialAnalysis-LRAPDIXB.js +236 -0
- package/dist/Disco-IDOTCKSD.js +3384 -0
- package/dist/Disco.UI-SLJKAA6N.js +239 -0
- package/dist/DmrPlot-5CRGQNM3.js +361 -0
- package/dist/GB-YCDIORF3.js +1388 -0
- package/dist/GSEA-IGWX3AG7.js +870 -0
- package/dist/GeneExpInput-PPOTCILZ.js +38 -0
- package/dist/Geomap-D5JPCJ5L.js +80 -0
- package/dist/HicApp-BNMMISAR.js +2240 -0
- package/dist/IDCViewer-IUPPLC5B.js +10808 -0
- package/dist/NumBinaryEditor-45I5YNHI.js +274 -0
- package/dist/NumBinaryEditor.unit.spec-5CJPIDH4.js +308 -0
- package/dist/NumContEditor-VMCE5LUM.js +100 -0
- package/dist/NumContEditor.unit.spec-DKNXTVXT.js +160 -0
- package/dist/NumCustomBinEditor-3EESV7PW.js +29 -0
- package/dist/NumCustomBinEditor.unit.spec-JPOK7BWZ.js +393 -0
- package/dist/NumDiscreteEditor-YZ3Q4J4M.js +165 -0
- package/dist/NumDiscreteEditor.unit.spec-V6NSX72E.js +229 -0
- package/dist/NumRegularBinEditor-6GI63X5V.js +29 -0
- package/dist/NumRegularBinEditor.unit.spec-KCGZLQ6T.js +274 -0
- package/dist/NumSplineEditor-OMJUFDSC.js +205 -0
- package/dist/NumSplineEditor.unit.spec-KUB2OITH.js +220 -0
- package/dist/NumericDensity-M4BIVIB3.js +29 -0
- package/dist/NumericDensity.unit.spec-G3GJMO4S.js +414 -0
- package/dist/NumericHandler-AMV4BETD.js +30 -0
- package/dist/NumericHandler.unit.spec-OJDMQQHX.js +225 -0
- package/dist/ProteomeInput-KB7YRARQ.js +610 -0
- package/dist/Regression-5KSKHUEJ.js +1412 -0
- package/dist/RunChart2-JJ4GQF44.js +744 -0
- package/dist/SC-LKCBWZQX.js +1290 -0
- package/dist/Violin-JRP7R53K.js +1092 -0
- package/dist/Volcano-BDD3PZ4T.js +2661 -0
- package/dist/Wsi-3C3ERYSG.js +636 -0
- package/dist/aboutSunburst-2T5SLCCB.js +93 -0
- package/dist/aboutSunburst-2T5SLCCB.js.map +7 -0
- package/dist/adSandbox-GFF6ZCRM.js +29 -0
- package/dist/animatedBubbleChart-PUPXCFJW.js +542 -0
- package/dist/app-EICBB32X.js +28 -0
- package/dist/app-Z7M3CFWA.js +38 -0
- package/dist/app.js +8 -8
- package/dist/bam-KQ5F34X5.js +872 -0
- package/dist/barchart-WRAEMD7B.js +38 -0
- package/dist/barchart2-5CX3CO4K.js +305 -0
- package/dist/block-53QIZEH3.js +6203 -0
- package/dist/block.init-4V3SIUNX.js +29 -0
- package/dist/block.mds.expressionrank-5YNTX35V.js +350 -0
- package/dist/block.mds.geneboxplot-X5OHLSWT.js +819 -0
- package/dist/block.mds.junction-QBJF6MFG.js +1534 -0
- package/dist/block.mds.svcnv-BNCMHJJB.js +6413 -0
- package/dist/block.svg-KQELYSEO.js +155 -0
- package/dist/block.tk.aicheck-5EDNNXGL.js +274 -0
- package/dist/block.tk.bam-FRPCGSAE.js +1906 -0
- package/dist/block.tk.bigwig.ui-XUJPSA6D.js +202 -0
- package/dist/block.tk.hicstraw-MVLZALFC.js +814 -0
- package/dist/block.tk.junction-DLZNHWSA.js +2353 -0
- package/dist/block.tk.junction.textmatrixui-J3EODITY.js +190 -0
- package/dist/block.tk.ld-4GEJ2Y2K.js +90 -0
- package/dist/block.tk.menu-NM7KA5GZ.js +1050 -0
- package/dist/block.tk.pgv-XFOJACVC.js +934 -0
- package/dist/brainImaging-WFRZQANN.js +550 -0
- package/dist/brainRegions-66KWCUF2.js +213 -0
- package/dist/bubbleHeatmap-VKLIJOMM.js +374 -0
- package/dist/cellTypeBubbleHeatmap-ZPCXC52I.js +274 -0
- package/dist/chunk-2NDFMFNM.js +134 -0
- package/dist/chunk-34AGCF72.js +203 -0
- package/dist/chunk-3KKI63GB.js +96 -0
- package/dist/chunk-3LUHZYIN.js +14 -0
- package/dist/chunk-4ASBDE27.js +26731 -0
- package/dist/chunk-4ASBDE27.js.map +7 -0
- package/dist/chunk-5XXYEKE2.js +237 -0
- package/dist/chunk-6C3USAU5.js +848 -0
- package/dist/chunk-7F2FBQRP.js +35 -0
- package/dist/chunk-7TRD7A2U.js +141 -0
- package/dist/chunk-AG2PISH4.js +257 -0
- package/dist/chunk-BGYZJXYZ.js +2799 -0
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- package/dist/chunk-QI4EZK7S.js +2941 -0
- package/dist/chunk-QNSB6O4W.js +70 -0
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- package/dist/chunk-R55JRVX7.js.map +7 -0
- package/dist/chunk-RSMASA5S.js +340 -0
- package/dist/chunk-S2BMWHFY.js +54 -0
- package/dist/chunk-SKL52OWF.js +466 -0
- package/dist/chunk-TRWUXFVB.js +102 -0
- package/dist/chunk-URCFNXAK.js +2008 -0
- package/dist/chunk-V2D7DA2M.js +194 -0
- package/dist/chunk-V2ZVMDBY.js +480 -0
- package/dist/chunk-VIFY62YA.js +243 -0
- package/dist/chunk-VZ2JWFSX.js +296 -0
- package/dist/chunk-W5GR42L2.js +159 -0
- package/dist/chunk-WDOX6A6T.js +1339 -0
- package/dist/chunk-XPL54FXR.js +6375 -0
- package/dist/chunk-XV3KWMG3.js +103 -0
- package/dist/chunk-YFFQ7JTJ.js +123 -0
- package/dist/chunk-ZD6AIFTS.js +1253 -0
- package/dist/chunk-ZDVYAOWC.js +516 -0
- package/dist/chunk-ZKIC65KR.js +2685 -0
- package/dist/chunk-ZPRI5XCE.js +82 -0
- package/dist/cohort-CI22KICX.js +66 -0
- package/dist/cohortSunburst-Z5DANXVS.js +402 -0
- package/dist/condition-GZOA7BZJ.js +323 -0
- package/dist/controls-OWC25VQN.js +30 -0
- package/dist/controls.config-UVC4Q7BS.js +30 -0
- package/dist/correlation-EBA5YVXA.js +91 -0
- package/dist/customdata.inputui-FZRZCPS3.js +280 -0
- package/dist/dataDownload-WIPQU33P.js +326 -0
- package/dist/databrowser.ui-6L6Q72W4.js +421 -0
- package/dist/dictionary-4VZEPGW5.js +109 -0
- package/dist/dnaMethylation-LN6THRNZ.js +29 -0
- package/dist/dnaMethylation.integration.spec-BXC6EPUV.js +194 -0
- package/dist/e2pca-EXFI4Q2Y.js +340 -0
- package/dist/ep-T7EZ34XV.js +1247 -0
- package/dist/expclust.gdc.spec-NAN4M75R.js +298 -0
- package/dist/facet-BJFUIWHK.js +556 -0
- package/dist/gb-CBC3PDKZ.js +77 -0
- package/dist/geneExpClustering-7JFY7TQT.js +240 -0
- package/dist/geneExpression-FOQOKD34.js +29 -0
- package/dist/geneExpression.unit.spec-XSFC5ZJP.js +151 -0
- package/dist/geneORA-KYPN66QU.js +269 -0
- package/dist/geneRanking-VEHFMRFL.js +544 -0
- package/dist/geneVariant-77V6FNJX.js +289 -0
- package/dist/geneVariant-BS3XZFYM.js +32 -0
- package/dist/geneVariant.integration.spec-US4OY3S5.js +672 -0
- package/dist/genefusion.ui-YNVTTLDE.js +299 -0
- package/dist/geneset-BH5MWNJQ.js +199 -0
- package/dist/genomeBrowser.spec-BFTGLRHG.js +272 -0
- package/dist/grin2-4AXUYJIL.js +66 -0
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- package/dist/hierCluster-IJHBVO2N.js +55 -0
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- package/dist/hierCluster.config-UUQEFTIG.js +32 -0
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- package/dist/hierCluster.interactivity-6CN5PNFR.js +45 -0
- package/dist/imagePlot-HKPPACFV.js +152 -0
- package/dist/importPlot-EMI6BVPR.js +8 -0
- package/dist/isoformExpression-SFBA3SY7.js +31 -0
- package/dist/isoformExpression.unit.spec-JKYWHGRN.js +233 -0
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- package/dist/launch.adhoc-R7SYX6GF.js +33 -0
- package/dist/leftlabel.sample-XJUDFAKS.js +253 -0
- package/dist/lollipop-V43BWGBT.js +162 -0
- package/dist/maf-KU44HXN3.js +451 -0
- package/dist/maftimeline-JPHVYTTU.js +583 -0
- package/dist/matrix-EABQEAMC.js +50 -0
- package/dist/matrix-HMLF5MDD.js +55 -0
- package/dist/matrix.config-RX5GWHTM.js +33 -0
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- package/dist/matrix.renderers-UGQXONTG.js +30 -0
- package/dist/matrix.sort.unit.spec-FJKIBDTU.js +464 -0
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- package/dist/matrix.unit.spec-7Y3BKFNQ.js +146 -0
- package/dist/mavb-ADD57P2Q.js +726 -0
- package/dist/mds.fimo-7WH5GVFZ.js +509 -0
- package/dist/mds.samplescatterplot-JYFOORUG.js +1545 -0
- package/dist/mds.survivalplot-2V4H3YZY.js +472 -0
- package/dist/multivalue-GLS3RPQ5.js +79 -0
- package/dist/oncomatrix-QA267TP2.js +286 -0
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- package/dist/plot.barplot-KBVYKICH.js +93 -0
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- package/dist/plot.brainImaging-GGUARYRT.js +51 -0
- package/dist/plot.disco-EP274JEW.js +98 -0
- package/dist/plot.ssgq-4VUH3ZWV.js +130 -0
- package/dist/plot.vaf2cov-2FPWA2FS.js +249 -0
- package/dist/polar2-7W5JRMB5.js +228 -0
- package/dist/profileForms-2IKL3SZU.js +937 -0
- package/dist/profilePlot-IURW2HQN.js +45 -0
- package/dist/proteinView-4ZRODQN3.js +1346 -0
- package/dist/proteomeCohortCompare-BK3FLW4Z.js +866 -0
- package/dist/pseudbulk.unit.spec-QGQCCHNF.js +82 -0
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- package/dist/selectGenomeWithTklst-LGBKEN3T.js +125 -0
- package/dist/singleCellCellType-ACQACM6W.js +29 -0
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- package/dist/singleCellGeneExpression-M4RPITJW.js +29 -0
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- /package/dist/{tvs.dtcnv.categorical-PPFQIC42.js.map → tvs.dtcnv.categorical-H7FKTXH4.js.map} +0 -0
- /package/dist/{tvs.dtcnv.continuous-TV2IGHY4.js.map → tvs.dtcnv.continuous-JQ62ZHER.js.map} +0 -0
- /package/dist/{tvs.dtfusion-ON4BA4XJ.js.map → tvs.dtfusion-GC3DZ2BO.js.map} +0 -0
- /package/dist/{tvs.dtitd-VFNROOWQ.js.map → tvs.dtitd-3SHGIDIB.js.map} +0 -0
- /package/dist/{tvs.dtsnvindel-ZXOP37T5.js.map → tvs.dtsnvindel-BEDWZ4A2.js.map} +0 -0
- /package/dist/{tvs.dtsv-EUHPTW7J.js.map → tvs.dtsv-HRIMULVD.js.map} +0 -0
- /package/dist/{tvs.multivalue-NHVXZNDI.js.map → tvs.multivalue-5VC7BLSZ.js.map} +0 -0
- /package/dist/{tvs.numeric-FPWDPO3J.js.map → tvs.numeric-TGEC7G6A.js.map} +0 -0
- /package/dist/{tvs.samplelst-ZZHRNUP4.js.map → tvs.samplelst-Q6EYAUQZ.js.map} +0 -0
- /package/dist/{tvs.survival-F3KSG3U6.js.map → tvs.survival-NJ3DTZIG.js.map} +0 -0
- /package/dist/{tvs.termCollection-B37DZLDY.js.map → tvs.termCollection-TVVLPSTG.js.map} +0 -0
- /package/dist/{vocabulary-XNE5FFDK.js.map → vocabulary-A7ZBBU65.js.map} +0 -0
- /package/dist/{wsi.direct-3YH3QGQD.js.map → wsi.direct-JJGIAH6A.js.map} +0 -0
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import {
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LegendCircleReference,
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PlotBase,
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addGeneSearchbox
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} from "./chunk-WD7FZ5EE.js";
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import "./chunk-HJ6L54YS.js";
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import "./chunk-WXSMUSU7.js";
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import {
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Menu
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} from "./chunk-CNFTQSNE.js";
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import "./chunk-TVJOSRCH.js";
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import "./chunk-3CIL7KH7.js";
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import {
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dofetch3
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} from "./chunk-4TJO2DGU.js";
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import "./chunk-W5J3LTYS.js";
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import "./chunk-WJLRU5OF.js";
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import {
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copyMerge,
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getCompInit
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} from "./chunk-HBNB5TRH.js";
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import "./chunk-PF4DSFDR.js";
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import {
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linear,
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sqrt
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} from "./chunk-4OLM3KSB.js";
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import "./chunk-PWYMHUXY.js";
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import "./chunk-TLT4YIG3.js";
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import "./chunk-5R63Q5KH.js";
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import "./chunk-I6Y4O3RR.js";
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import "./chunk-HS5PO5ZQ.js";
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// plots/cellTypeBubbleHeatmap.ts
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var defaultConfig = { chartType: "cellTypeBubbleHeatmap" };
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var CELL_W = 84;
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var CELL_H = 60;
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var ROW_LABEL_W = 74;
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var GROUP_LABEL_H = 22;
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var GENO_LABEL_H = 40;
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var COL_LABEL_H = GROUP_LABEL_H + GENO_LABEL_H;
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var MIN_DOT_R = 8;
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var MAX_DOT_R = 22;
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var NEG_LOG_FDR_CAP = 10;
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var COLOR_NEG = "#762a83";
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var COLOR_ZERO = "#f7f7f7";
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var COLOR_POS = "#2166ac";
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var CellTypeBubbleHeatmap = class _CellTypeBubbleHeatmap extends PlotBase {
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constructor(opts, api) {
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super(opts, api);
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this.currentIsoform = "";
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this.type = _CellTypeBubbleHeatmap.type;
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}
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static {
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this.type = "cellTypeBubbleHeatmap";
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}
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async init() {
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const holder = this.opts.holder.append("div").style("padding", "10px");
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this.dom = {
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holder,
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body: holder.append("div"),
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tip: new Menu({ padding: "" }),
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header: this.opts.header
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};
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if (this.dom.header) this.dom.header.html("Cell-type Bubble Heatmap");
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}
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getState(appState) {
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const config = appState.plots.find((p) => p.id === this.id);
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if (!config) throw `No plot with id='${this.id}' found`;
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return { config };
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}
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async main() {
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const gene = this.state.config?.gene;
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if (!gene) throw new Error("cellTypeBubbleHeatmap: gene is missing");
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if (this.dom.header) this.dom.header.text(`Cell-type Bubble Heatmap: ${gene}`);
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const body = {
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genome: this.app.opts.state.vocab.genome,
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dslabel: this.app.opts.state.vocab.dslabel,
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gene
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};
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const data = await dofetch3("termdb/cellTypeBubbleHeatmap", { body });
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if (data.error) throw data.error;
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this.data = data;
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this.dom.body.selectAll("*").remove();
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const isoformIds = Object.keys(data.isoforms);
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if (isoformIds.length === 0) {
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this.dom.body.append("div").style("padding", "20px").style("color", "#666").text(`No data found for gene "${gene}" in any cohort DAPfile.`);
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return;
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}
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this.currentIsoform = isoformIds[0];
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const isoBlock = this.dom.body.append("div").style("margin-bottom", "12px");
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isoBlock.append("span").style("font-weight", "bold").text("Isoform: ");
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if (isoformIds.length > 1) {
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const sel = isoBlock.append("select").style("margin-left", "5px").style("padding", "3px 6px").on("change", () => {
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this.currentIsoform = sel.node().value;
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this.renderGrid();
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});
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sel.selectAll("option").data(isoformIds).enter().append("option").attr("value", (d) => d).text((d) => `${data.isoforms[d].gene_name} \u2014 ${d}`);
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} else {
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isoBlock.append("span").style("margin-left", "5px").text(`${data.isoforms[this.currentIsoform].gene_name} \u2014 ${this.currentIsoform}`);
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}
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this.gridHolder = this.dom.body.append("div");
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this.renderGrid();
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}
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renderGrid() {
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const data = this.data;
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const selectedIsoform = this.currentIsoform;
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const threshold = data.fdrThreshold;
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this.gridHolder.selectAll("*").remove();
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const container = this.gridHolder.append("div").style("display", "flex").style("gap", "24px").style("align-items", "flex-start").style("flex-wrap", "wrap");
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const isoformData = data.isoforms[selectedIsoform];
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if (!isoformData) return;
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const columns = data.columns;
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const rows = data.rows;
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const nCols = columns.length;
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const nRows = rows.length;
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const negLogFdr = (fdr) => fdr > 0 ? Math.min(-Math.log10(fdr), NEG_LOG_FDR_CAP) : NEG_LOG_FDR_CAP;
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const cellOf = (colKey, rowKey) => isoformData.data[colKey]?.[rowKey];
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let maxAbs = 0;
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const thresholdNegLog = negLogFdr(threshold);
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let maxNegLog = thresholdNegLog;
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for (const col of columns) {
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for (const row of rows) {
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const s = cellOf(col.key, row.key);
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if (!s) continue;
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const v = Math.abs(s.log2FC);
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if (v > maxAbs) maxAbs = v;
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const nl = negLogFdr(s.fdr);
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if (nl > maxNegLog) maxNegLog = nl;
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}
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}
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if (maxAbs === 0) maxAbs = 1;
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if (maxNegLog <= thresholdNegLog) maxNegLog = thresholdNegLog + 1;
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const colorScale = linear().domain([-maxAbs, 0, maxAbs]).range([COLOR_NEG, COLOR_ZERO, COLOR_POS]).clamp(true);
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const sizeScale = sqrt().domain([thresholdNegLog, maxNegLog]).range([MIN_DOT_R, MAX_DOT_R]).clamp(true);
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const gridW = ROW_LABEL_W + nCols * CELL_W + 20;
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const gridH = COL_LABEL_H + nRows * CELL_H + 20;
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const svg = container.append("svg").attr("width", gridW).attr("height", gridH).style("flex", "0 0 auto");
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const grid = svg.append("g");
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let c = 0;
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while (c < nCols) {
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const cellType = columns[c].cellType;
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let end = c;
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while (end + 1 < nCols && columns[end + 1].cellType === cellType) end++;
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const xStart = ROW_LABEL_W + c * CELL_W;
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const xEnd = ROW_LABEL_W + (end + 1) * CELL_W;
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const xMid = (xStart + xEnd) / 2;
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grid.append("text").attr("x", xMid).attr("y", GROUP_LABEL_H - 7).attr("text-anchor", "middle").attr("font-size", "13px").attr("font-weight", "bold").text(cellType);
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grid.append("line").attr("x1", xStart + 4).attr("y1", GROUP_LABEL_H - 3).attr("x2", xEnd - 4).attr("y2", GROUP_LABEL_H - 3).attr("stroke", "#bbb").attr("stroke-width", 1);
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c = end + 1;
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}
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for (let col = 0; col < nCols; col++) {
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const cx = ROW_LABEL_W + col * CELL_W + CELL_W / 2;
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grid.append("text").attr("x", cx).attr("y", COL_LABEL_H - 14).attr("text-anchor", "middle").attr("font-size", "12px").attr("font-weight", "600").text(columns[col].genotype);
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}
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for (let r = 0; r < nRows; r++) {
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const cy = COL_LABEL_H + r * CELL_H + CELL_H / 2;
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grid.append("text").attr("x", ROW_LABEL_W - 12).attr("y", cy).attr("text-anchor", "end").attr("dominant-baseline", "central").attr("font-size", "13px").attr("font-weight", "bold").text(rows[r].label);
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}
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for (let r = 0; r < nRows; r++) {
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for (let col = 0; col < nCols; col++) {
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const x0 = ROW_LABEL_W + col * CELL_W;
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const y0 = COL_LABEL_H + r * CELL_H;
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grid.append("rect").attr("x", x0).attr("y", y0).attr("width", CELL_W).attr("height", CELL_H).attr("fill", "none").attr("stroke", "#eee").attr("stroke-width", 1);
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const s = cellOf(columns[col].key, rows[r].key);
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if (!s) continue;
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const cx = x0 + CELL_W / 2;
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const cy = y0 + CELL_H / 2;
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grid.append("circle").attr("cx", cx).attr("cy", cy).attr("r", sizeScale(negLogFdr(s.fdr))).attr("fill", colorScale(s.log2FC)).attr("stroke", "#888").attr("stroke-width", 0.8).style("opacity", s.significant ? 1 : 0.35).on(
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"mouseover",
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(event) => this.showCellTip(event, isoformData.gene_name, selectedIsoform, columns[col], rows[r], s)
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).on("mouseout", () => this.dom.tip.hide());
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}
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}
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this.renderLegend(container, colorScale, maxAbs, threshold, maxNegLog);
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}
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fmtFdr(v) {
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return v >= 1e-4 ? v.toFixed(4) : v.toExponential(2);
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}
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showCellTip(event, geneName, isoform, col, row, s) {
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this.dom.tip.clear().show(event.clientX, event.clientY);
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const t = this.dom.tip.d.append("div").style("padding", "8px").style("font-size", "13px");
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t.append("div").style("font-weight", "bold").style("margin-bottom", "4px").text(`${geneName} \u2014 ${isoform}`);
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t.append("div").text(`Cell type: ${col.cellType}`);
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t.append("div").text(`Genotype: ${col.genotype}`);
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t.append("div").text(`Timepoint: ${row.label}`);
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t.append("div").text(`Protein: ${s.id}`);
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t.append("div").text(`log\u2082FC: ${s.log2FC.toFixed(3)}`);
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t.append("div").text(`FDR: ${this.fmtFdr(s.fdr)}${s.significant ? "" : " (n.s.)"}`);
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t.append("div").style("color", "#666").style("margin-top", "4px").text("Color = log\u2082FC (blue up / purple down). Size = \u2212log\u2081\u2080 FDR.");
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}
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renderLegend(container, colorScale, maxAbs, threshold, maxNegLog) {
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const legend = container.append("div").style("display", "flex").style("flex-direction", "column").style("gap", "16px").style("padding", "8px 0").style("min-width", "180px").style("max-width", "260px");
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const colorBlock = legend.append("div");
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colorBlock.append("div").style("font-weight", "bold").style("font-size", "13px").style("margin-bottom", "6px").text("log\u2082FC");
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const cW = 22;
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const cH = 130;
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const cSvg = colorBlock.append("svg").attr("width", cW + 80).attr("height", cH + 16);
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const gid = `ctbh-grad-${this.id}`;
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const grad = cSvg.append("defs").append("linearGradient").attr("id", gid).attr("x1", "0").attr("y1", "0").attr("x2", "0").attr("y2", "1");
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const steps = 10;
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for (let i = 0; i <= steps; i++) {
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const t = i / steps;
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grad.append("stop").attr("offset", `${t * 100}%`).attr("stop-color", colorScale(maxAbs * (1 - 2 * t)));
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}
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cSvg.append("rect").attr("x", 0).attr("y", 8).attr("width", cW).attr("height", cH).style("fill", `url(#${gid})`).attr("stroke", "#999");
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const cScale = linear().domain([maxAbs, -maxAbs]).range([8, cH + 8]);
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for (const tick of [maxAbs, maxAbs / 2, 0, -maxAbs / 2, -maxAbs]) {
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const y = cScale(tick);
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cSvg.append("line").attr("x1", cW).attr("y1", y).attr("x2", cW + 5).attr("y2", y).attr("stroke", "#666");
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cSvg.append("text").attr("x", cW + 8).attr("y", y).attr("dominant-baseline", "central").attr("font-size", "10px").text(`${tick > 0 ? "+" : ""}${tick.toFixed(2)}`);
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}
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colorBlock.append("div").style("font-size", "11px").style("color", "#666").style("margin-top", "2px").text("blue = up (+), purple = down (\u2212)");
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const sizeBlock = legend.append("div");
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sizeBlock.append("div").style("font-weight", "bold").style("font-size", "13px").style("margin-bottom", "6px").text("Dot size: significance (\u2212log\u2081\u2080 FDR)");
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const sSvg = sizeBlock.append("svg");
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const sG = sSvg.append("g");
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new LegendCircleReference({
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g: sG,
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inputMin: 0,
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inputMax: MAX_DOT_R * 2,
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minRadius: MIN_DOT_R,
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maxRadius: MAX_DOT_R,
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minLabel: Number(Math.min(-Math.log10(threshold), NEG_LOG_FDR_CAP).toFixed(1)),
|
|
229
|
-
maxLabel: Number(maxNegLog.toFixed(1))
|
|
230
|
-
});
|
|
231
|
-
const sPad = 4;
|
|
232
|
-
const sBox = sG.node().getBBox();
|
|
233
|
-
sG.attr("transform", `translate(${sPad - sBox.x}, ${sPad - sBox.y})`);
|
|
234
|
-
sSvg.attr("width", Math.ceil(sBox.width + 2 * sPad)).attr("height", Math.ceil(sBox.height + 2 * sPad));
|
|
235
|
-
const notes = legend.append("div").style("font-size", "11px").style("color", "#666").style("line-height", "1.5").style("max-width", "240px").style("overflow-wrap", "break-word");
|
|
236
|
-
notes.append("div").text(
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|
237
|
-
`Color = log\u2082FC (blue up, purple down). Dot size = significance, \u2212log\u2081\u2080 FDR; the smallest size marks the FDR < ${threshold} cutoff. Non-significant dots (FDR \u2265 ${threshold}) are faded.`
|
|
238
|
-
);
|
|
239
|
-
notes.append("div").style("margin-top", "4px").text("An empty cell means the cohort was not assayed (e.g. OPC has no 4m) or the protein was not detected.");
|
|
240
|
-
}
|
|
241
|
-
};
|
|
242
|
-
var componentInit = getCompInit(CellTypeBubbleHeatmap);
|
|
243
|
-
async function getPlotConfig(opts) {
|
|
244
|
-
const config = structuredClone(defaultConfig);
|
|
245
|
-
if (!opts.gene) throw new Error("cellTypeBubbleHeatmap requires opts.gene");
|
|
246
|
-
return copyMerge(config, opts);
|
|
247
|
-
}
|
|
248
|
-
function makeChartBtnMenu(holder, chartsInstance) {
|
|
249
|
-
const row = holder.append("div").style("padding", "5px");
|
|
250
|
-
row.append("span").style("font-weight", "bold").text("Enter a gene name:");
|
|
251
|
-
const geneSearch = addGeneSearchbox({
|
|
252
|
-
row,
|
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253
|
-
genome: chartsInstance.app.opts.genome,
|
|
254
|
-
tip: new Menu({ padding: "0px" }),
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255
|
-
searchOnly: "gene",
|
|
256
|
-
callback: async () => {
|
|
257
|
-
if (!geneSearch.geneSymbol) throw new Error("A valid gene selection is required");
|
|
258
|
-
chartsInstance.dom.tip.hide();
|
|
259
|
-
chartsInstance.app.dispatch({
|
|
260
|
-
type: "plot_create",
|
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261
|
-
config: {
|
|
262
|
-
chartType: "cellTypeBubbleHeatmap",
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|
263
|
-
gene: geneSearch.geneSymbol
|
|
264
|
-
}
|
|
265
|
-
});
|
|
266
|
-
}
|
|
267
|
-
});
|
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|
-
}
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|
-
export {
|
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270
|
-
componentInit,
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271
|
-
getPlotConfig,
|
|
272
|
-
makeChartBtnMenu
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};
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|
-
//# sourceMappingURL=cellTypeBubbleHeatmap-HJY53DB2.js.map
|
package/dist/chunk-226MNBZ2.js
DELETED
|
@@ -1,240 +0,0 @@
|
|
|
1
|
-
import {
|
|
2
|
-
make_radios
|
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3
|
-
} from "./chunk-WD7FZ5EE.js";
|
|
4
|
-
import {
|
|
5
|
-
initBinConfig
|
|
6
|
-
} from "./chunk-4TJO2DGU.js";
|
|
7
|
-
import {
|
|
8
|
-
toStoredUnit,
|
|
9
|
-
toUserUnit
|
|
10
|
-
} from "./chunk-W5J3LTYS.js";
|
|
11
|
-
import {
|
|
12
|
-
format
|
|
13
|
-
} from "./chunk-4OLM3KSB.js";
|
|
14
|
-
|
|
15
|
-
// termsetting/handlers/NumRegularBinEditor.ts
|
|
16
|
-
var NumRegularBinEditor = class {
|
|
17
|
-
constructor(editHandler) {
|
|
18
|
-
this.dom = {};
|
|
19
|
-
this.editHandler = editHandler;
|
|
20
|
-
this.opts = editHandler.opts;
|
|
21
|
-
this.tw = editHandler.tw;
|
|
22
|
-
this.termsetting = editHandler.termsetting;
|
|
23
|
-
}
|
|
24
|
-
/* q holds bin boundaries in the unit the term's values are stored in, while the <input>s and the
|
|
25
|
-
density plot show them in the term's user-facing unit. toDisplay()/toStored() cross that boundary;
|
|
26
|
-
both are identity functions unless the term declares valueConversion{} */
|
|
27
|
-
toDisplay(v) {
|
|
28
|
-
return toUserUnit(v, this.tw.term);
|
|
29
|
-
}
|
|
30
|
-
toStored(v) {
|
|
31
|
-
return toStoredUnit(v, this.tw.term);
|
|
32
|
-
}
|
|
33
|
-
render(div) {
|
|
34
|
-
this.tw = this.editHandler.tw;
|
|
35
|
-
const isRemounting = !!this.dom.binsTable && this.editHandler.dom.binsDiv?.node().contains(this.dom.binsTable.node());
|
|
36
|
-
if (!isRemounting) this.q = this.getDefaultQ();
|
|
37
|
-
this.editHandler.handler.density.setBinLines(this.getBoundaryOpts());
|
|
38
|
-
if (isRemounting) return;
|
|
39
|
-
if (this.dom.binsTable) {
|
|
40
|
-
this.dom.binsTable.remove();
|
|
41
|
-
delete this.dom.binsTable;
|
|
42
|
-
}
|
|
43
|
-
const binsTable = div.append("table");
|
|
44
|
-
this.dom.binsTable = binsTable;
|
|
45
|
-
this.renderBinSizeInput(binsTable.append("tr"));
|
|
46
|
-
this.renderFirstBinInput(binsTable.append("tr"));
|
|
47
|
-
this.renderLastBinInputs(binsTable.append("tr"));
|
|
48
|
-
}
|
|
49
|
-
getDefaultQ() {
|
|
50
|
-
if (this.tw.q.type == "regular-bin") return JSON.parse(JSON.stringify(this.tw.q));
|
|
51
|
-
const t = this.tw.term;
|
|
52
|
-
const defaultQ = this.termsetting.opts.use_bins_less && t.bins?.less || t.bins?.default;
|
|
53
|
-
if (defaultQ) return JSON.parse(JSON.stringify(defaultQ));
|
|
54
|
-
const binConfig = initBinConfig(this.editHandler.handler.density_data);
|
|
55
|
-
return typeof binConfig == "string" ? JSON.parse(binConfig) : binConfig;
|
|
56
|
-
}
|
|
57
|
-
renderBinSizeInput(tr) {
|
|
58
|
-
const handler = this.editHandler.handler;
|
|
59
|
-
tr.append("td").style("margin", "5px").style("opacity", 0.5).text("Bin Size");
|
|
60
|
-
const { min, max } = handler.density_data;
|
|
61
|
-
const q = this.q;
|
|
62
|
-
const origBinSize = this.toDisplay(q.bin_size);
|
|
63
|
-
this.dom.bin_size_input = tr.append("td").append("input").attr("type", "number").attr(
|
|
64
|
-
"value",
|
|
65
|
-
handler.density.scaleFactor == 1 && "rounding" in q ? format(q.rounding || ".0f")(q.bin_size) : origBinSize
|
|
66
|
-
).attr("data-testid", "sjpp-num-reg-bin-editor-size").style("margin-left", "15px").style("width", "100px").style("color", () => q.bin_size > Math.abs(max - min) ? "red" : "").on("change", (event) => {
|
|
67
|
-
const newValue = this.toStored(Number(event.target.value));
|
|
68
|
-
if (newValue <= 0) {
|
|
69
|
-
window.alert("Please enter non-negative bin size.");
|
|
70
|
-
event.target.value = origBinSize;
|
|
71
|
-
return;
|
|
72
|
-
}
|
|
73
|
-
if ((max - min) / newValue > 100) {
|
|
74
|
-
window.alert("Bin size too small. Try setting a bigger value.");
|
|
75
|
-
event.target.value = origBinSize;
|
|
76
|
-
return;
|
|
77
|
-
}
|
|
78
|
-
q.bin_size = newValue;
|
|
79
|
-
this.dom.bin_size_input.style(
|
|
80
|
-
"color",
|
|
81
|
-
q.bin_size > max - min ? "red" : this.toDisplay(newValue) != origBinSize ? "green" : ""
|
|
82
|
-
);
|
|
83
|
-
handler.density.setBinLines(this.getBoundaryOpts());
|
|
84
|
-
});
|
|
85
|
-
}
|
|
86
|
-
renderFirstBinInput(tr) {
|
|
87
|
-
const handler = this.editHandler.handler;
|
|
88
|
-
const q = this.q;
|
|
89
|
-
if (!q.first_bin) throw "missing q.first_bin";
|
|
90
|
-
tr.append("td").style("margin", "5px").style("opacity", 0.5).text("First Bin Stop");
|
|
91
|
-
const { min, max } = handler.density_data;
|
|
92
|
-
const origValue = this.toDisplay(q.first_bin.stop);
|
|
93
|
-
this.dom.first_stop_input = tr.append("td").append("input").attr("type", "number").property("value", origValue).style("width", "100px").style("margin-left", "15px").on("change", (event) => {
|
|
94
|
-
const newValue = this.toStored(Number(event.target.value));
|
|
95
|
-
if (Number(event.target.value) < this.toDisplay(min) || Number(event.target.value) > this.toDisplay(max)) {
|
|
96
|
-
window.alert("First bin stop value out of bound.");
|
|
97
|
-
event.target.value = origValue;
|
|
98
|
-
return;
|
|
99
|
-
}
|
|
100
|
-
this.q.first_bin.stop = newValue;
|
|
101
|
-
handler.density.setBinLines(this.getBoundaryOpts());
|
|
102
|
-
});
|
|
103
|
-
tr.append("td").append("div").style("font-size", ".6em").style("opacity", 0.5).style("display", handler.density.no_density_data ? "none" : "block").text("Indicated by left-most red line. Drag to change.");
|
|
104
|
-
}
|
|
105
|
-
renderLastBinInputs(tr) {
|
|
106
|
-
const handler = this.editHandler.handler;
|
|
107
|
-
const q = this.q;
|
|
108
|
-
const isAuto = !q.last_bin || !Number.isFinite(q.last_bin.start);
|
|
109
|
-
tr.append("td").style("padding-top", "4px").style("opacity", 0.5).style("vertical-align", "top").text("Last Bin Start");
|
|
110
|
-
const td1 = tr.append("td").style("padding-left", "15px").style("vertical-align", "top");
|
|
111
|
-
const radio_div = td1.append("div");
|
|
112
|
-
const radios = make_radios({
|
|
113
|
-
holder: radio_div,
|
|
114
|
-
options: [
|
|
115
|
-
{ label: "Automatic", value: "auto", checked: isAuto },
|
|
116
|
-
{ label: "Fixed", value: "fixed", checked: !isAuto }
|
|
117
|
-
],
|
|
118
|
-
callback: (v) => {
|
|
119
|
-
if (v == "auto") {
|
|
120
|
-
delete q.last_bin;
|
|
121
|
-
edit_div.style("display", "none");
|
|
122
|
-
handler.density.setBinLines(this.getBoundaryOpts());
|
|
123
|
-
return;
|
|
124
|
-
}
|
|
125
|
-
edit_div.style("display", "inline-block");
|
|
126
|
-
if (this.dom.last_start_input.property("value") == "") {
|
|
127
|
-
this.dom.last_start_input.property(
|
|
128
|
-
"value",
|
|
129
|
-
this.toDisplay(this.tw.q.last_bin?.start || handler.density_data.max)
|
|
130
|
-
);
|
|
131
|
-
}
|
|
132
|
-
this.setLastBinStart();
|
|
133
|
-
}
|
|
134
|
-
});
|
|
135
|
-
this.dom.fixed_radio = radios.inputs.filter((_, i) => i === 1);
|
|
136
|
-
const edit_div = tr.append("td").append("div").style("display", isAuto ? "none" : "inline-block");
|
|
137
|
-
this.dom.last_start_input = edit_div.append("input").attr("type", "number").property("value", Number.isFinite(q.last_bin?.start) ? this.toDisplay(q.last_bin.start) : "").style("width", "100px").on("change", () => this.setLastBinStart());
|
|
138
|
-
edit_div.append("div").style("font-size", ".6em").style("opacity", 0.5).style("display", handler.density.no_density_data ? "none" : "block").text("Indicated by right-most red line. Drag to change.");
|
|
139
|
-
}
|
|
140
|
-
setLastBinStart() {
|
|
141
|
-
const q = this.q;
|
|
142
|
-
const { max } = this.editHandler.handler.density_data;
|
|
143
|
-
const strInput = this.dom.last_start_input.property("value");
|
|
144
|
-
if (strInput === "") return;
|
|
145
|
-
const inputValue = this.toStored(Number(strInput));
|
|
146
|
-
if (q.first_bin && Number(strInput) <= this.toDisplay(q.first_bin.stop)) {
|
|
147
|
-
window.alert("Last bin start cannot be smaller than first bin stop.");
|
|
148
|
-
this.dom.last_start_input.property("value", this.toDisplay(max));
|
|
149
|
-
return;
|
|
150
|
-
}
|
|
151
|
-
if (Number(strInput) > this.toDisplay(max)) {
|
|
152
|
-
window.alert("Last bin start value out of bound.");
|
|
153
|
-
this.dom.last_start_input.property("value", this.toDisplay(max));
|
|
154
|
-
return;
|
|
155
|
-
}
|
|
156
|
-
if (q.last_bin) q.last_bin.start = inputValue;
|
|
157
|
-
else
|
|
158
|
-
q.last_bin = {
|
|
159
|
-
start: inputValue,
|
|
160
|
-
stopunbounded: true,
|
|
161
|
-
stopinclusive: false
|
|
162
|
-
};
|
|
163
|
-
this.editHandler.handler.density.setBinLines(this.getBoundaryOpts());
|
|
164
|
-
}
|
|
165
|
-
getBoundaryOpts() {
|
|
166
|
-
const { min, max } = this.editHandler.handler.density_data;
|
|
167
|
-
const binLinesStop = this.q.last_bin?.start ?? max + Math.abs(this.q.first_bin.stop) - Math.min(min, 0);
|
|
168
|
-
const boundaryValues = [];
|
|
169
|
-
for (let i = this.q.first_bin.stop; i <= binLinesStop; i = i + this.q.bin_size) {
|
|
170
|
-
if (this.q.last_bin?.start === i) break;
|
|
171
|
-
if (i > binLinesStop) boundaryValues[boundaryValues.length - 1].isLastVisibleLine = true;
|
|
172
|
-
const isDraggable = i === this.q.first_bin.stop || i === this.q.bin_size - 1;
|
|
173
|
-
boundaryValues.push({ x: this.toDisplay(i), isDraggable, movesWithLineIndex: !isDraggable ? 0 : -1 });
|
|
174
|
-
}
|
|
175
|
-
if (this.q.last_bin) {
|
|
176
|
-
boundaryValues.push({
|
|
177
|
-
x: this.toDisplay(this.q.last_bin.start),
|
|
178
|
-
isDraggable: true,
|
|
179
|
-
isLastVisibleLine: true,
|
|
180
|
-
movesWithLineIndex: -1
|
|
181
|
-
});
|
|
182
|
-
}
|
|
183
|
-
return {
|
|
184
|
-
values: boundaryValues,
|
|
185
|
-
// the dragged value arrives in display units, matching what the <input>s show
|
|
186
|
-
callback: (d, value) => {
|
|
187
|
-
if (d.index === 0) {
|
|
188
|
-
this.dom.first_stop_input.property("value", value);
|
|
189
|
-
this.q.first_bin.stop = this.toStored(value);
|
|
190
|
-
} else {
|
|
191
|
-
this.dom.last_start_input.property("value", value);
|
|
192
|
-
if (this.q.last_bin) this.q.last_bin.start = this.toStored(value);
|
|
193
|
-
}
|
|
194
|
-
}
|
|
195
|
-
};
|
|
196
|
-
}
|
|
197
|
-
getEditedQ(destroyDom = true) {
|
|
198
|
-
const bin_size = this.dom.bin_size_input.property("value");
|
|
199
|
-
const config = {
|
|
200
|
-
mode: "discrete",
|
|
201
|
-
type: "regular-bin",
|
|
202
|
-
startinclusive: this.editHandler.boundaryInclusion == "startinclusive",
|
|
203
|
-
stopinclusive: this.editHandler.boundaryInclusion == "stopinclusive",
|
|
204
|
-
bin_size: this.toStored(Number(bin_size)),
|
|
205
|
-
first_bin: {
|
|
206
|
-
startunbounded: true,
|
|
207
|
-
stop: this.toStored(Number(this.dom.first_stop_input.property("value")))
|
|
208
|
-
},
|
|
209
|
-
/* rounding formats the stored bin size, so it cannot be derived from the decimals of a
|
|
210
|
-
converted input. a converted term labels its bins through valueConversion instead */
|
|
211
|
-
rounding: this.editHandler.handler.density.scaleFactor != 1 ? ".0f" : bin_size.includes(".") && !bin_size.endsWith(".") ? `.${bin_size.split(".")[1].length}f` : ".0f"
|
|
212
|
-
};
|
|
213
|
-
if (this.dom.fixed_radio.property("checked")) {
|
|
214
|
-
config.last_bin = {
|
|
215
|
-
start: this.toStored(Number(this.dom.last_start_input.property("value"))),
|
|
216
|
-
stopunbounded: true
|
|
217
|
-
};
|
|
218
|
-
}
|
|
219
|
-
if (destroyDom) {
|
|
220
|
-
for (const name of Object.keys(this.dom)) {
|
|
221
|
-
this.dom[name].remove();
|
|
222
|
-
delete this.dom[name];
|
|
223
|
-
}
|
|
224
|
-
}
|
|
225
|
-
return config;
|
|
226
|
-
}
|
|
227
|
-
undoEdits() {
|
|
228
|
-
this.q = this.getDefaultQ();
|
|
229
|
-
this.dom.binsTable.selectAll("*").remove();
|
|
230
|
-
this.renderBinSizeInput(this.dom.binsTable.append("tr"));
|
|
231
|
-
this.renderFirstBinInput(this.dom.binsTable.append("tr"));
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|
232
|
-
this.renderLastBinInputs(this.dom.binsTable.append("tr"));
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|
233
|
-
this.editHandler.handler.density.setBinLines(this.getBoundaryOpts());
|
|
234
|
-
}
|
|
235
|
-
};
|
|
236
|
-
|
|
237
|
-
export {
|
|
238
|
-
NumRegularBinEditor
|
|
239
|
-
};
|
|
240
|
-
//# sourceMappingURL=chunk-226MNBZ2.js.map
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