@sjcrh/proteinpaint-client 2.220.0 → 2.222.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (864) hide show
  1. package/dist/2dmaf-QFXSYOYN.js +1362 -0
  2. package/dist/AggMatrixInput-7D4ZUYJK.js +402 -0
  3. package/dist/AggregateMatrix-NVSFZEW3.js +37 -0
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  5. package/dist/BoxPlot-52WWBGKN.js +1229 -0
  6. package/dist/CorrelationVolcano-WS23O2JT.js +613 -0
  7. package/dist/Cuminc-5LJQYFEE.js +1217 -0
  8. package/dist/DE-Z5GBDXDU.js +85 -0
  9. package/dist/DEinput-3EAIVG5U.js +479 -0
  10. package/dist/DM-24NZPPS6.js +86 -0
  11. package/dist/DifferentialAnalysis-LRAPDIXB.js +236 -0
  12. package/dist/Disco-IDOTCKSD.js +3384 -0
  13. package/dist/Disco.UI-SLJKAA6N.js +239 -0
  14. package/dist/DmrPlot-5CRGQNM3.js +361 -0
  15. package/dist/GB-YCDIORF3.js +1388 -0
  16. package/dist/GSEA-IGWX3AG7.js +870 -0
  17. package/dist/GeneExpInput-PPOTCILZ.js +38 -0
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  37. package/dist/ProteomeInput-KB7YRARQ.js +610 -0
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  143. package/dist/cohort-CI22KICX.js +66 -0
  144. package/dist/cohortSunburst-Z5DANXVS.js +402 -0
  145. package/dist/condition-GZOA7BZJ.js +323 -0
  146. package/dist/controls-OWC25VQN.js +30 -0
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  148. package/dist/correlation-EBA5YVXA.js +91 -0
  149. package/dist/customdata.inputui-FZRZCPS3.js +280 -0
  150. package/dist/dataDownload-WIPQU33P.js +326 -0
  151. package/dist/databrowser.ui-6L6Q72W4.js +421 -0
  152. package/dist/dictionary-4VZEPGW5.js +109 -0
  153. package/dist/dnaMethylation-LN6THRNZ.js +29 -0
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  161. package/dist/geneExpression-FOQOKD34.js +29 -0
  162. package/dist/geneExpression.unit.spec-XSFC5ZJP.js +151 -0
  163. package/dist/geneORA-KYPN66QU.js +269 -0
  164. package/dist/geneRanking-VEHFMRFL.js +544 -0
  165. package/dist/geneVariant-77V6FNJX.js +289 -0
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  168. package/dist/genefusion.ui-YNVTTLDE.js +299 -0
  169. package/dist/geneset-BH5MWNJQ.js +199 -0
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  806. /package/dist/{singleCellGeneExpression.unit.spec-JVHPFLML.js.map → singleCellGeneExpression.unit.spec-N3VD6PUW.js.map} +0 -0
  807. /package/dist/{singleCellNumericValue-FHIECJDK.js.map → singleCellNumericValue-W6F44FJN.js.map} +0 -0
  808. /package/dist/{singleCellNumericValue.unit.spec-ZFG56MIO.js.map → singleCellNumericValue.unit.spec-JZNMY77I.js.map} +0 -0
  809. /package/dist/{singleCellPlot-NDGIW32L.js.map → singleCellPlot-CCG2KSCO.js.map} +0 -0
  810. /package/dist/{singlecell-JPWVPZEF.js.map → singlecell-32P47E4I.js.map} +0 -0
  811. /package/dist/{singlecell-N7RJMWZ2.js.map → singlecell-I6H3Z7FT.js.map} +0 -0
  812. /package/dist/{snp-APUTOL2F.js.map → snp-7X2BXRQP.js.map} +0 -0
  813. /package/dist/{snp.unit.spec-4AN7AJKO.js.map → snp.unit.spec-BJGWNSVR.js.map} +0 -0
  814. /package/dist/{snplocus-WIMFAMBE.js.map → snplocus-UOVS2GD6.js.map} +0 -0
  815. /package/dist/{snplst-SUJ5AK4E.js.map → snplst-JFVP4NG2.js.map} +0 -0
  816. /package/dist/{spliceevent.a53ss.diagram-4UBI7PFJ.js.map → spliceevent.a53ss.diagram-ETXJX57W.js.map} +0 -0
  817. /package/dist/{spliceevent.exonskip.diagram-NVEXVRIC.js.map → spliceevent.exonskip.diagram-C4JCEOXQ.js.map} +0 -0
  818. /package/dist/{spliceevent.noeventdiagram-CKEWNLVF.js.map → spliceevent.noeventdiagram-4DD3Z4OM.js.map} +0 -0
  819. /package/dist/{ssGSEA-CJOVXTAW.js.map → ssGSEA-GOZOYROM.js.map} +0 -0
  820. /package/dist/{ssGSEA.unit.spec-A7VRVJSF.js.map → ssGSEA.unit.spec-J4DPFU4D.js.map} +0 -0
  821. /package/dist/{stattable-JBJVVLQE.js.map → stattable-ICUZQHUF.js.map} +0 -0
  822. /package/dist/{studyCatalog-NEL7XSIP.js.map → studyCatalog-PCFXVOI3.js.map} +0 -0
  823. /package/dist/{summarizeCnvGeneexp-BZSCTA5W.js.map → summarizeCnvGeneexp-DK6HNUFE.js.map} +0 -0
  824. /package/dist/{summarizeGeneexpSurvival-743KXNV7.js.map → summarizeGeneexpSurvival-JLCR2VIX.js.map} +0 -0
  825. /package/dist/{summarizeMutationCnv-CALMSQGV.js.map → summarizeMutationCnv-CFAKT6IP.js.map} +0 -0
  826. /package/dist/{summarizeMutationDiagnosis-OTE7O4AS.js.map → summarizeMutationDiagnosis-5HMVSYMI.js.map} +0 -0
  827. /package/dist/{summarizeMutationSurvival-VOZOFTFM.js.map → summarizeMutationSurvival-GP2OQMUS.js.map} +0 -0
  828. /package/dist/{summary-XJKCD35N.js.map → summary-6K553VNS.js.map} +0 -0
  829. /package/dist/{summary.integration.spec-OOEU6WNB.js.map → summary.integration.spec-MXERZOVY.js.map} +0 -0
  830. /package/dist/{summaryInput-JSOXVSMY.js.map → summaryInput-V2G6HFJS.js.map} +0 -0
  831. /package/dist/{sunburst-J3QHMYKW.js.map → sunburst-6GKVNIRF.js.map} +0 -0
  832. /package/dist/{sunburst-LZPP6NPV.js.map → sunburst-YOVKC5G2.js.map} +0 -0
  833. /package/dist/{survival-FW7N3YXZ.js.map → survival-GHTV2ZPX.js.map} +0 -0
  834. /package/dist/{survival-5GWRVTQ6.js.map → survival-KF2QUWSM.js.map} +0 -0
  835. /package/dist/{survival.integration.spec-WN36VUHL.js.map → survival.integration.spec-GVSQL4VB.js.map} +0 -0
  836. /package/dist/{svgraph-N35EMK3G.js.map → svgraph-WN3JLEOC.js.map} +0 -0
  837. /package/dist/{svmr-EWL5WDDD.js.map → svmr-ZZKBQFQK.js.map} +0 -0
  838. /package/dist/{swimmer-Z6FUH4CD.js.map → swimmer-XHORJEVI.js.map} +0 -0
  839. /package/dist/{table-EI2OIRGE.js.map → table-XQCTNHSZ.js.map} +0 -0
  840. /package/dist/{termCollection-K3EX5P3F.js.map → termCollection-DXZQT7YT.js.map} +0 -0
  841. /package/dist/{termCollection-TBTAHLVH.js.map → termCollection-HRM2NHLA.js.map} +0 -0
  842. /package/dist/{termCollection.unit.spec-ZVNAIPHZ.js.map → termCollection.unit.spec-BGULSLH6.js.map} +0 -0
  843. /package/dist/{termCollectionFractionSelection-ATNIPWVX.js.map → termCollectionFractionSelection-TPNNP2ER.js.map} +0 -0
  844. /package/dist/{termCollectionFractionSelection.unit.spec-VBRWWBML.js.map → termCollectionFractionSelection.unit.spec-VONXAGZH.js.map} +0 -0
  845. /package/dist/{tk-P3RPLUVH.js.map → tk-KPD6HTHR.js.map} +0 -0
  846. /package/dist/{tk-U6CYISBH.js.map → tk-RCTQPQH7.js.map} +0 -0
  847. /package/dist/{tp.ui-KBFYUSWS.js.map → tp.ui-MVNQLMAD.js.map} +0 -0
  848. /package/dist/{tvs.categorical-5USP772O.js.map → tvs.categorical-4TKKU6HO.js.map} +0 -0
  849. /package/dist/{tvs.condition-652MAA2Z.js.map → tvs.condition-SARY3O5Y.js.map} +0 -0
  850. /package/dist/{tvs.density-CB24PXDE.js.map → tvs.density-IGO4I4T2.js.map} +0 -0
  851. /package/dist/{tvs.dt-7BTARQUS.js.map → tvs.dt-XJ2MW2AP.js.map} +0 -0
  852. /package/dist/{tvs.dtcnv.categorical-GAOO3DGO.js.map → tvs.dtcnv.categorical-H7FKTXH4.js.map} +0 -0
  853. /package/dist/{tvs.dtcnv.continuous-P2QRD45O.js.map → tvs.dtcnv.continuous-JQ62ZHER.js.map} +0 -0
  854. /package/dist/{tvs.dtfusion-L3I65W7L.js.map → tvs.dtfusion-GC3DZ2BO.js.map} +0 -0
  855. /package/dist/{tvs.dtitd-B3JPW6OL.js.map → tvs.dtitd-3SHGIDIB.js.map} +0 -0
  856. /package/dist/{tvs.dtsnvindel-6Y6CJBZV.js.map → tvs.dtsnvindel-BEDWZ4A2.js.map} +0 -0
  857. /package/dist/{tvs.dtsv-GL7CPATL.js.map → tvs.dtsv-HRIMULVD.js.map} +0 -0
  858. /package/dist/{tvs.multivalue-75IM23FZ.js.map → tvs.multivalue-5VC7BLSZ.js.map} +0 -0
  859. /package/dist/{tvs.numeric-XB3GBPHE.js.map → tvs.numeric-TGEC7G6A.js.map} +0 -0
  860. /package/dist/{tvs.samplelst-QUA45UE7.js.map → tvs.samplelst-Q6EYAUQZ.js.map} +0 -0
  861. /package/dist/{tvs.survival-EKSDZZIO.js.map → tvs.survival-NJ3DTZIG.js.map} +0 -0
  862. /package/dist/{tvs.termCollection-5ATMDC7O.js.map → tvs.termCollection-TVVLPSTG.js.map} +0 -0
  863. /package/dist/{vocabulary-5QBBQAYC.js.map → vocabulary-A7ZBBU65.js.map} +0 -0
  864. /package/dist/{wsi.direct-BU6BL5UR.js.map → wsi.direct-JJGIAH6A.js.map} +0 -0
@@ -1,1193 +0,0 @@
1
- import {
2
- getFilterName,
3
- makelabel,
4
- printCategory,
5
- rangequery_rglst,
6
- setLeftlabelsMaxWidth
7
- } from "./chunk-VSDJEPDN.js";
8
- import {
9
- makeJunctionCustomTerm
10
- } from "./chunk-MANAUI7R.js";
11
- import {
12
- rehydrateFilter
13
- } from "./chunk-FE5TCBIT.js";
14
- import "./chunk-5YQXNW6Y.js";
15
- import {
16
- legend_newrow
17
- } from "./chunk-PIN5YUVJ.js";
18
- import "./chunk-V2OJLJSK.js";
19
- import "./chunk-4FTH4L3A.js";
20
- import "./chunk-VLIOMJDR.js";
21
- import {
22
- axisstyle,
23
- table2col
24
- } from "./chunk-PEKCVKJK.js";
25
- import "./chunk-HJ6L54YS.js";
26
- import "./chunk-YR6EXI2K.js";
27
- import {
28
- Menu
29
- } from "./chunk-CNFTQSNE.js";
30
- import "./chunk-RIHO7ZD5.js";
31
- import "./chunk-TVJOSRCH.js";
32
- import "./chunk-3CIL7KH7.js";
33
- import "./chunk-T4XPCSLP.js";
34
- import {
35
- dofetch3
36
- } from "./chunk-4TJO2DGU.js";
37
- import "./chunk-W5J3LTYS.js";
38
- import "./chunk-MHWYRNGA.js";
39
- import "./chunk-JHLF2ZC2.js";
40
- import {
41
- JT_a3ss,
42
- JT_a5ss,
43
- JT_canonical,
44
- JT_exonaltuse,
45
- JT_exonskip,
46
- JTypes,
47
- TermTypes,
48
- axisRight,
49
- bplen,
50
- collide_default,
51
- simulation_default,
52
- x_default,
53
- y_default
54
- } from "./chunk-WJLRU5OF.js";
55
- import "./chunk-HBNB5TRH.js";
56
- import "./chunk-PF4DSFDR.js";
57
- import {
58
- linear,
59
- log
60
- } from "./chunk-4OLM3KSB.js";
61
- import "./chunk-6XKAOSQE.js";
62
- import {
63
- roundValueAuto
64
- } from "./chunk-TLT4YIG3.js";
65
- import "./chunk-5R63Q5KH.js";
66
- import {
67
- select_default
68
- } from "./chunk-I6Y4O3RR.js";
69
- import "./chunk-Q5RDQNIT.js";
70
- import "./chunk-HS5PO5ZQ.js";
71
-
72
- // j2/legend.js
73
- function initLegend(tk, block) {
74
- if (!block.legend) return;
75
- if (!tk.legend) tk.legend = {};
76
- tk.legend.tip = new Menu({ padding: "0px" });
77
- const [tr, td, td0] = legend_newrow(block, tk.custom_data ? tk.name : tk.dslabel);
78
- tk.legend.headTd = td0;
79
- tk.tr_legend = tr;
80
- const table = td.append("table").style("border-spacing", "5px").style("border-collapse", "separate");
81
- tk.legend.table = table;
82
- create_type(tk, block);
83
- }
84
- function updateLegend(data, tk, block) {
85
- if (!tk.legend) {
86
- return;
87
- }
88
- update_type(tk);
89
- }
90
- function create_type(tk, block) {
91
- if (!tk.legend.type) tk.legend.type = {};
92
- if (!tk.legend.type.hiddenvalues) tk.legend.type.hiddenvalues = /* @__PURE__ */ new Set();
93
- if (tk.hiddentypes) {
94
- for (const c of tk.hiddentypes.split(",")) tk.legend.type.hiddenvalues.add(c);
95
- delete tk.hiddentypes;
96
- }
97
- tk.legend.type.row = tk.legend.table.append("tr");
98
- tk.legend.type.row.append("td").attr("data-testid", "sjpp-j2-legend-row-type").style("text-align", "right").style("opacity", 0.7).text(tk.deltaPsiGroups ? "PSI" : "Type");
99
- tk.legend.type.holder = tk.legend.type.row.append("td");
100
- }
101
- function update_type(tk) {
102
- if (tk.deltaPsiGroups) return update_deltaPsi(tk);
103
- const type2count = /* @__PURE__ */ new Map();
104
- for (const j of tk.data) {
105
- for (const t of j.types) {
106
- type2count.set(t, 1 + (type2count.get(t) || 0));
107
- }
108
- }
109
- tk.legend.type.holder.selectAll("*").remove();
110
- for (const [t, c] of [...type2count].sort((i, j) => j[1] - i[1])) {
111
- printCategory({
112
- holder: tk.legend.type.holder,
113
- key: t,
114
- label: JTypes[t].name,
115
- color: JTypes[t].color,
116
- count: c,
117
- testid: "sjpp-j2-legend-row-type-item",
118
- click: (event) => {
119
- const opts = [
120
- {
121
- label: "Hide",
122
- callback: () => {
123
- tk.legend.type.hiddenvalues.add(t);
124
- }
125
- },
126
- {
127
- label: "Show only",
128
- callback: () => {
129
- for (const t2 of type2count.keys()) {
130
- tk.legend.type.hiddenvalues.add(t2);
131
- }
132
- tk.legend.type.hiddenvalues.delete(t);
133
- }
134
- },
135
- {
136
- label: "Show all",
137
- isVisible: () => tk.legend.type.hiddenvalues.size,
138
- callback: () => {
139
- tk.legend.type.hiddenvalues.clear();
140
- }
141
- }
142
- ];
143
- tk.legend.tip.clear().showunder(event.target);
144
- for (const o of opts) {
145
- if (o.isVisible && o.isVisible() == false) continue;
146
- tk.legend.tip.d.append("div").attr("class", "sja_menuoption").attr("data-testid", `sjpp-legend-option-${o.label.toLowerCase().replace(/\s/g, "-")}`).style("border-radius", "0px").text(o.label).on("click", () => {
147
- o.callback();
148
- tk.legend.tip.hide();
149
- tk.load();
150
- });
151
- }
152
- }
153
- });
154
- }
155
- for (const c of tk.legend.type.hiddenvalues) {
156
- let loading = false;
157
- tk.legend.type.holder.append("div").style("display", "inline-block").attr("class", "sja_clb").style("text-decoration", "line-through").style("opacity", 0.7).text(JTypes[c].name).on("click", async (event) => {
158
- if (loading) return;
159
- loading = true;
160
- tk.legend.type.hiddenvalues.delete(c);
161
- event.target.innerHTML = "Updating...";
162
- await tk.load();
163
- });
164
- }
165
- }
166
- function update_deltaPsi(tk) {
167
- tk.legend.type.holder.selectAll("*").remove();
168
- const { case: _case, control } = tk.deltaPsiGroups;
169
- const categories = [
170
- { key: "case", label: `${_case.name} > ${control.name}`, color: _case.color },
171
- { key: "control", label: `${control.name} > ${_case.name}`, color: control.color },
172
- { key: void 0, label: "Equal or missing", color: "#858585" }
173
- ];
174
- for (const c of categories) {
175
- const count = tk.data.filter((j) => j.higherPsiIn == c.key).length;
176
- if (!count && !c.key) continue;
177
- printCategory({
178
- holder: tk.legend.type.holder,
179
- key: c.key || "none",
180
- label: c.label,
181
- color: c.color,
182
- count,
183
- testid: "sjpp-j2-legend-row-type-item"
184
- });
185
- }
186
- }
187
-
188
- // j2/render.js
189
- var minfontsize = 12;
190
- var lineopacity = 0.5;
191
- var discopacity = 0.5;
192
- function renderTk(data, tk, block) {
193
- if (data) {
194
- tk.sections.jug.yAxisKey = tk.custom_data && data.junctions.every((j) => Number.isFinite(j.negLog10p)) ? "negLog10p" : !tk.custom_data || Number.isFinite(data.maxReadCount) ? "medianReadCount" : void 0;
195
- if (data.junctions?.length == 0) {
196
- tk.data = [];
197
- tk.leftlabels?.doms?.jug?.text("0 junctions");
198
- return;
199
- }
200
- if (tk.sections.jug.yAxisKey == "medianReadCount" && !Number.isFinite(data.maxReadCount))
201
- throw new Error("data.maxReadCount is not number");
202
- tk.maxReadCount = data.maxReadCount;
203
- if (rawdata2track(data.junctions, tk, block)) {
204
- tk.data = [];
205
- data.junctions = [];
206
- tk.leftlabels.doms.jug.text("0 junctions");
207
- return;
208
- }
209
- } else {
210
- }
211
- tk.leftlabels.doms.jug.text(`${tk.data.length} junction${tk.data.length > 1 ? "s" : ""}`);
212
- const viewpxwidth = block.width + block.subpanels.reduce((i, j) => i + j.leftpad + j.width, 0);
213
- setColor(tk);
214
- tk.sections.jug.g.selectAll("*").remove();
215
- const mg = tk.sections.jug.g;
216
- tk.data.sort((a, b) => {
217
- return a._x - b._x;
218
- });
219
- {
220
- const maxsamplecount = tk.data.reduce((max, j) => Math.max(max, j.sampleCount ?? 1), 0);
221
- const radius = 5;
222
- let mrd = 0;
223
- const w = Math.pow(radius, 2) * Math.PI;
224
- if (maxsamplecount <= 10) {
225
- mrd = w * maxsamplecount * 0.9;
226
- } else if (maxsamplecount <= 100) {
227
- mrd = w * 10;
228
- } else if (maxsamplecount <= 1e3) {
229
- mrd = w * 14;
230
- } else {
231
- mrd = w * 20;
232
- }
233
- const sf_discradius = linear().domain([
234
- 1,
235
- maxsamplecount * 0.5 + 0.1,
236
- maxsamplecount * 0.6 + 0.1,
237
- maxsamplecount * 0.7 + 0.1,
238
- maxsamplecount * 0.8 + 0.1,
239
- maxsamplecount
240
- ]).range([w, w + (mrd - w) * 0.8, w + (mrd - w) * 0.85, w + (mrd - w) * 0.9, w + (mrd - w) * 0.95, mrd]);
241
- let maxradius = 0;
242
- for (const j of tk.data) {
243
- j.radius = Math.sqrt(sf_discradius(j.sampleCount ?? 1) / Math.PI);
244
- if (j.sampleCount > 1) {
245
- mg.append("text").attr("font-family", "Arial").attr("font-size", Math.max(minfontsize, j.radius)).text(j.sampleCount).each(function() {
246
- const b = this.getBBox();
247
- const newrad = Math.sqrt(Math.pow(b.width, 2) + Math.pow(b.height, 2)) / 2;
248
- j.radius = Math.max(j.radius, newrad);
249
- }).remove();
250
- }
251
- j.rimwidth = j.rimcount ? Math.max(2, j.radius / 6) : 0;
252
- j.radius2 = j.radius + j.rimwidth + (j.rimwidth > 0 ? 1 : 0);
253
- maxradius = Math.max(maxradius, j.radius2);
254
- }
255
- tk.maxradius = maxradius;
256
- }
257
- const maxmedian = tk.data.reduce((c, j) => Math.max(c, j.medianReadCount), 0);
258
- tk.sections.jug.yscale = tk.sections.jug.yAxisKey == "medianReadCount" ? (tk.yscaleUseLog ? log() : linear()).domain([tk.readcountCutoff || 1, tk.maxReadCount]).range([tk.sections.jug.axisheight, 0]) : linear().domain([0, Math.max(1, ...tk.data.map((j) => yValue(j, tk)))]).nice().range([tk.sections.jug.axisheight, 0]);
259
- for (const j of tk.data) {
260
- if (j.axisy == void 0) {
261
- j.axisy = tk.sections.jug.axisheight - tk.sections.jug.yscale(yValue(j, tk));
262
- }
263
- }
264
- tk.sections.jug.height = tk.sections.jug.axisheight + tk.sections.jug.neckheight + tk.sections.jug.legheight;
265
- mg.attr("transform", `translate(0,${tk.sections.jug.height})`);
266
- {
267
- const topy = -tk.sections.jug.legheight - tk.sections.jug.neckheight - tk.sections.jug.axisheight;
268
- mg.append("line").attr("x1", 0).attr("y1", topy).attr("y2", topy).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("shape-rendering", "crispEdges");
269
- mg.append("line").attr("x1", 0).attr("y1", topy + tk.sections.jug.axisheight).attr("y2", topy + tk.sections.jug.axisheight).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("shape-rendering", "crispEdges");
270
- let v = 10;
271
- while (tk.sections.jug.yAxisKey == "medianReadCount" && v <= tk.maxReadCount) {
272
- mg.append("line").attr("x1", 0).attr("y1", topy + tk.sections.jug.yscale(v)).attr("y2", topy + tk.sections.jug.yscale(v)).attr("x2", viewpxwidth).attr("stroke", "#858585").attr("stroke-opacity", 0.2).attr("stroke-dasharray", "4,4").attr("shape-rendering", "crispEdges");
273
- v *= 10;
274
- }
275
- }
276
- const jug = mg.selectAll().data(tk.data).enter().append("g").attr("class", "sja_jug").attr("transform", (d) => set_jug(d)).each(function(j) {
277
- j.jugg = this;
278
- });
279
- jug.append("line").attr("stroke", (d) => d.color).attr("x1", (d) => set_leg_x1(d)).attr("y2", -tk.sections.jug.legheight).attr("stroke-opacity", lineopacity).attr("class", "sja_jug_leg1").each(function(d) {
280
- d.leg1 = this;
281
- });
282
- jug.append("line").attr("stroke", (d) => d.color).attr("x2", (d) => set_leg_x2(d)).attr("y1", -tk.sections.jug.legheight).attr("stroke-opacity", lineopacity).attr("class", "sja_jug_leg2").each(function(d) {
283
- d.leg2 = this;
284
- });
285
- const jug2 = jug.append("g").attr("class", "sja_jug_jug2").attr("transform", (d) => set_jug2(d, tk));
286
- jug2.append("line").attr("stroke", (d) => d.color).attr("class", "sja_jug_stem").attr("stroke-dasharray", "2,2").attr("shape-rendering", "crispEdges").attr("y1", (d) => d.radius).attr("y2", (d) => {
287
- return tk.sections.jug.neckheight + d.axisy;
288
- }).attr("stroke-opacity", lineopacity).each(function(d) {
289
- d.stem = this;
290
- });
291
- jug2.append("circle").each(function(d) {
292
- d.disc = this;
293
- }).attr("r", (d) => d.radius).attr("fill", (d) => d.color).attr("stroke", "white").attr("fill-opacity", discopacity);
294
- jug2.filter((d) => d.sampleCount > 1).append("text").text((d) => d.sampleCount).attr("font-size", (d) => Math.max(minfontsize, d.radius)).attr("class", "sja_jug_discnum").attr("fill", "white").attr("font-family", "Arial").attr("text-anchor", "middle").attr("dominant-baseline", "central");
295
- jug2.append("circle").attr("r", (d) => d.radius).attr("stroke", (d) => d.color).attr("fill", "white").attr("fill-opacity", 0).attr("stroke-opacity", 0).on("mouseover", (event, d) => {
296
- event.stopPropagation();
297
- select_default(d.disc).attr("fill-opacity", 0.8);
298
- select_default(d.stem).attr("stroke-opacity", 1);
299
- select_default(d.leg1).attr("stroke-opacity", 1);
300
- select_default(d.leg2).attr("stroke-opacity", 1);
301
- mouseoverSpanBackground(d, tk, block, viewpxwidth);
302
- mouseoverBoxplot(d, tk);
303
- const p = event.target.getBoundingClientRect();
304
- tk.hovertip.clear().show(p.left + p.width, p.top - 50);
305
- showOneJunction(d, tk, tk.hovertip.d, block);
306
- }).on("mouseout", (event, d) => {
307
- tk.hovertip.hide();
308
- tk.pica.g.selectAll("*").remove();
309
- block.cursorhlbar.attr("fill", block.cursorhlbarFillColor);
310
- select_default(d.disc).attr("fill-opacity", discopacity);
311
- select_default(d.stem).attr("stroke-opacity", lineopacity);
312
- select_default(d.leg1).attr("stroke-opacity", lineopacity);
313
- select_default(d.leg2).attr("stroke-opacity", lineopacity);
314
- }).on("mousedown", (event) => {
315
- event.stopPropagation();
316
- }).on("mousemove", (event) => {
317
- event.stopPropagation();
318
- }).on("click", (event, d) => {
319
- tk.hovertip.hide();
320
- const p = event.target.getBoundingClientRect();
321
- tk.itemtip.clear().show(p.left + p.width, p.top - 50);
322
- showOneJunction(d, tk, tk.itemtip.d.append("div"), block, true);
323
- });
324
- doForceLayout(tk, block, viewpxwidth).then(() => {
325
- set_all(tk);
326
- axisstyle({
327
- axis: tk.sections.jug.axis.transition().call(
328
- axisRight().scale(tk.sections.jug.yscale).ticks(
329
- tk.sections.jug.yAxisKey ? Math.floor(tk.sections.jug.axisheight / 20) : 0,
330
- tk.sections.jug.yAxisKey == "medianReadCount" ? ".0f" : void 0
331
- )
332
- ),
333
- color: "black",
334
- showline: true
335
- });
336
- });
337
- }
338
- function rawdata2track(raw, tk, block) {
339
- const viewpxwidth = block.width + block.subpanels.reduce((i, j) => i + j.leftpad + j.width, 0);
340
- const junctions = [];
341
- for (const j of raw) {
342
- if (j.sv && j.chr == j.sv.mate.chr) {
343
- if (j.start > j.sv.mate.start) {
344
- const p = j.start;
345
- j.start = j.stop = j.sv.mate.start;
346
- j.sv.mate.start = j.sv.mate.stop = p;
347
- const q = j.strand;
348
- j.strand = j.sv.mate.strand;
349
- j.sv.mate.strand = q;
350
- }
351
- }
352
- const e = j2block(j, block, viewpxwidth);
353
- if (e) {
354
- console.log(
355
- "junction not in view range: " + j.chr + ":" + j.start + "-" + (j.sv ? j.sv.mate.chr + ":" + j.sv.mate.start : j.stop)
356
- );
357
- continue;
358
- }
359
- junctions.push(j);
360
- }
361
- if (tk.data) {
362
- const map = /* @__PURE__ */ new Map();
363
- tk.data.forEach((j) => map.set(j.chr + "." + j.start + "." + j.stop + "." + j.strand, j));
364
- const pannedpx = Number.isInteger(block.pannedpx) ? block.pannedpx : 0;
365
- for (const i of junctions) {
366
- const j = map.get(i.chr + "." + i.start + "." + i.stop + "." + i.strand);
367
- if (j) {
368
- i.x = j.x + pannedpx;
369
- i.axisy = j.axisy;
370
- }
371
- }
372
- }
373
- if (junctions.length == 0) {
374
- return "no junctions in view range";
375
- }
376
- tk.data = junctions;
377
- }
378
- function j2block(j, block, viewpxwidth) {
379
- let starthit;
380
- let stophit;
381
- {
382
- const l = block.seekcoord(j.chr, j.start);
383
- for (const hit of l) {
384
- if (hit.ridx != void 0 && block.subpanels) {
385
- if (hit.x < 0 || hit.x > block.width) {
386
- continue;
387
- }
388
- }
389
- starthit = hit;
390
- }
391
- }
392
- {
393
- const l = block.seekcoord(j.sv ? j.sv.mate.chr : j.chr, j.sv ? j.sv.mate.start : j.stop);
394
- for (const hit of l) {
395
- if (hit.ridx != void 0 && block.subpanels) {
396
- if (hit.x < 0 || hit.x > block.width) {
397
- continue;
398
- }
399
- }
400
- stophit = hit;
401
- }
402
- }
403
- if (starthit) {
404
- if (!stophit) {
405
- stophit = starthit;
406
- }
407
- } else {
408
- if (stophit) {
409
- starthit = stophit;
410
- } else {
411
- return true;
412
- }
413
- }
414
- let startout = starthit.x < 0 || starthit.x > viewpxwidth;
415
- let stopout = stophit.x < 0 || stophit.x > viewpxwidth;
416
- if (startout && stopout) {
417
- return true;
418
- }
419
- j.x0 = starthit.x;
420
- j.x1 = stophit.x;
421
- j.x = (j.x0 + j.x1) / 2;
422
- j._x = j.x;
423
- return false;
424
- }
425
- function yValue(j, tk) {
426
- return tk.sections.jug.yAxisKey ? j[tk.sections.jug.yAxisKey] : 0;
427
- }
428
- function setColor(tk) {
429
- for (const j of tk.data) {
430
- delete j.color;
431
- const d = tk.deltaPsiGroups && j.psi_case != null && j.psi_control != null ? j.psi_case - j.psi_control : 0;
432
- j.higherPsiIn = d > 0 ? "case" : d < 0 ? "control" : void 0;
433
- if (j.higherPsiIn) {
434
- j.color = tk.deltaPsiGroups[j.higherPsiIn].color;
435
- } else if (tk.deltaPsiGroups || tk.custom_data && !j.types.length) {
436
- j.color = "#858585";
437
- } else {
438
- j.color = JTypes[j.types[0]]?.color;
439
- if (j.color == void 0) throw new Error("unknown j.type");
440
- }
441
- }
442
- }
443
- function set_jug(d) {
444
- return "translate(" + d.x + ",0)";
445
- }
446
- function set_leg_x1(d) {
447
- return d.x0 - d.x;
448
- }
449
- function set_leg_x2(d) {
450
- return d.x1 - d.x;
451
- }
452
- function set_jug2(d, tk) {
453
- return "translate(0,-" + (tk.sections.jug.legheight + tk.sections.jug.neckheight + d.axisy) + ")";
454
- }
455
- function set_all(tk) {
456
- const mg = tk.sections.jug;
457
- tk.data.forEach((j) => j.axisy = mg.axisheight - mg.yscale(yValue(j, tk)));
458
- const dur = 500;
459
- mg.g.selectAll(".sja_jug_leg1").transition().duration(dur).attr("y2", -mg.legheight).attr("x1", (d) => set_leg_x1(d));
460
- mg.g.selectAll(".sja_jug_leg2").transition().duration(dur).attr("y1", -mg.legheight).attr("x2", (d) => set_leg_x2(d));
461
- mg.g.selectAll(".sja_jug_jug2").transition().duration(dur).attr("transform", (d) => set_jug2(d, tk));
462
- mg.g.selectAll(".sja_jug").transition().duration(dur).attr("transform", (d) => set_jug(d));
463
- mg.g.selectAll(".sja_jug_stem").transition().duration(dur).attr("y2", (d) => mg.neckheight + d.axisy);
464
- }
465
- function doForceLayout(tk, block, viewpxwidth) {
466
- const nodes = [];
467
- let sumdiscwidth = 0;
468
- tk.data.map((j) => {
469
- let tox;
470
- if (j.x0 < 0) {
471
- tox = j.x1 - j.radius2 * 2;
472
- } else if (j.x1 > viewpxwidth) {
473
- tox = j.x0 + j.radius2 * 2;
474
- } else {
475
- tox = j._x;
476
- }
477
- nodes.push({
478
- junction: j,
479
- tox,
480
- x: tox,
481
- y: tk.sections.jug.axisheight - tk.sections.jug.yscale(yValue(j, tk))
482
- });
483
- sumdiscwidth += j.radius2 * 2;
484
- });
485
- nodes.sort((i, j) => i.tox - j.tox);
486
- nodes.forEach((n, i) => n.index = i);
487
- const collidestrength = sumdiscwidth <= viewpxwidth ? 1 : viewpxwidth / sumdiscwidth;
488
- return new Promise((resolve, reject) => {
489
- simulation_default(nodes).force(
490
- "y",
491
- y_default((d) => {
492
- return tk.sections.jug.axisheight - tk.sections.jug.yscale(yValue(d.junction, tk));
493
- }).strength(1)
494
- ).force("x", x_default((d) => d.tox).strength(0.1)).force(
495
- "collide",
496
- collide_default((d) => {
497
- return d.junction.radius2 + 2;
498
- }).strength(collidestrength)
499
- ).alphaMin(0.5).on("end", () => {
500
- nodes.forEach((n) => {
501
- n.junction.x = n.x;
502
- });
503
- resolve();
504
- });
505
- });
506
- }
507
- function mouseoverSpanBackground(j, tk, block, viewpxwidth) {
508
- let xleft = Math.min(j.x0, j.x1);
509
- let xright = Math.max(j.x0, j.x1);
510
- if (block.usegm && block.usegm.strand == "-") {
511
- xleft = j.x1;
512
- xright = j.x0;
513
- }
514
- if (xleft >= 0 && xright <= viewpxwidth) {
515
- block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xleft).attr("y", 0).attr("width", xright - xleft).attr("height", block.totalheight()).attr("fill", "url(#" + tk.gradient4spanBackground.mid.id + ")");
516
- return;
517
- }
518
- const boxwidth = 50;
519
- if (xleft >= 0) {
520
- block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xleft).attr("fill", "url(#" + tk.gradient4spanBackground.left.id + ")");
521
- } else {
522
- block.cursorhlbar.attr("x", block.leftheadw + block.lpad + xright - boxwidth).attr("fill", "url(#" + tk.gradient4spanBackground.right.id + ")");
523
- }
524
- block.cursorhlbar.attr("y", 0).attr("width", boxwidth).attr("height", block.totalheight());
525
- }
526
- function mouseoverBoxplot(j, tk) {
527
- if (!j.readcountBoxplot) return;
528
- const color = "black";
529
- const p5 = tk.sections.jug.yscale(j.readcountBoxplot[0]);
530
- const p25 = tk.sections.jug.yscale(j.readcountBoxplot[1]);
531
- const p50 = tk.sections.jug.yscale(j.readcountBoxplot[2]);
532
- const p75 = tk.sections.jug.yscale(j.readcountBoxplot[3]);
533
- const p95 = tk.sections.jug.yscale(j.readcountBoxplot[4]);
534
- const w = 10;
535
- tk.pica.g.selectAll("*").remove();
536
- tk.pica.g.attr("transform", "translate(" + j.x + "," + p50 + ")");
537
- const g = tk.pica.g.append("g").attr("transform", "translate(" + (-5 - w - j.radius2) + ",0)");
538
- g.append("line").attr("x1", w / 2).attr("x2", w / 2).attr("y1", p95 - p50).attr("y2", p5 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
539
- g.append("line").attr("x1", 0).attr("x2", w).attr("y1", p5 - p50).attr("y2", p5 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
540
- g.append("line").attr("x1", 0).attr("x2", w).attr("y1", p95 - p50).attr("y2", p95 - p50).attr("stroke", color).attr("shape-rendering", "crispEdges");
541
- g.append("rect").attr("y", p75 - p50).attr("width", w).attr("height", p25 - p75).attr("stroke", color).attr("fill", "white").attr("shape-rendering", "crispEdges");
542
- if (p25 - p75 > 3) {
543
- g.append("line").attr("x2", w).attr("stroke", color).attr("shape-rendering", "crispEdges");
544
- }
545
- }
546
- function showOneJunction(j, tk, holder, block, isClickMenu = false) {
547
- const table = table2col({ holder, margin: "0px" });
548
- {
549
- const [t1, t2] = table.addRow();
550
- t1.text("Junction");
551
- const div = t2.append("div");
552
- if (!j.sv || j.chr == j.sv.mate.chr) {
553
- div.html(
554
- bplen(Math.abs(j.start - (j.sv ? j.sv.mate.start : j.stop))) + ' <span style="font-size:.8em;">' + j.chr + ":" + (j.start + 1) + "-" + ((j.sv ? j.sv.mate.start : j.stop) + 1) + "</span>"
555
- );
556
- } else {
557
- div.html(
558
- '<span style="font-size:.8em;">' + j.chr + ":" + (j.start + 1) + "-" + j.sv.mate.chr + ":" + (j.sv.mate.start + 1) + "</span>"
559
- );
560
- }
561
- const d2 = t2.append("div");
562
- if (j.strand) {
563
- d2.append("span").attr("class", "sja_mcdot").style("padding", "1px 5px").style("background-color", "#555").style("margin-right", "5px").text(j.strand);
564
- }
565
- if (j.info.site) {
566
- d2.append("span").style("font-size", ".7em").style("margin-right", "5px").text(j.info.site);
567
- }
568
- for (const t of j.types) {
569
- d2.append("span").attr("class", "sja_mcdot").style("padding", "1px 5px").style("background-color", JTypes[t]?.color || "black").style("margin-right", "5px").text(JTypes[t]?.name || "?");
570
- }
571
- }
572
- if (Number.isFinite(j.p)) table.addRow("p-value", roundValueAuto(j.p));
573
- if ("psi_control" in j || "psi_case" in j) {
574
- const psi = (v) => v == null ? "NA" : roundValueAuto(v);
575
- table.addRow(`PSI, ${tk.deltaPsiGroups?.control.name || "control"}`, psi(j.psi_control));
576
- table.addRow(`PSI, ${tk.deltaPsiGroups?.case.name || "case"}`, psi(j.psi_case));
577
- if (j.psi_control != null && j.psi_case != null) table.addRow("\u0394PSI", roundValueAuto(j.psi_case - j.psi_control));
578
- }
579
- if (Number.isFinite(j.medianReadCount)) {
580
- const [t1, t2] = table.addRow();
581
- if (!(j.sampleCount > 1)) {
582
- t1.text("Sample");
583
- const sndiv = t2.append("div");
584
- sndiv.text(j.sampleName || "single sample");
585
- t2.append("div").html(j.medianReadCount + ' <span style="font-size:.7em">read count</span>');
586
- } else {
587
- t1.text("Samples");
588
- t2.append("div").html(`${j.sampleCount} <span style="font-size:.7em">samples</span>
589
- <br>${j.medianReadCount} <span style="font-size:.7em">median read count</span>`);
590
- }
591
- }
592
- if (isClickMenu && tk.massApp) {
593
- const [, buttonCell] = table.addRow();
594
- buttonCell.append("button").attr("data-testid", "sjpp-junction-details").text("Details").on("click", async () => {
595
- tk.itemtip.hide();
596
- await tk.massApp.dispatch({
597
- type: "plot_create",
598
- config: {
599
- chartType: "summary",
600
- term: { term: makeJunctionTerm(j), q: { mode: "continuous" } }
601
- }
602
- });
603
- });
604
- buttonCell.append("button").attr("data-testid", "sjpp-junction-select").text("Select").on("click", async (event) => {
605
- await addJunctionCustomTerm(tk, [makeJunctionTerm(j)], event.currentTarget, msgDiv);
606
- });
607
- const msgDiv = buttonCell.append("div").style("font-size", ".7em");
608
- }
609
- const type2elst = /* @__PURE__ */ new Map();
610
- for (const e of j.info?.events || []) {
611
- if (!type2elst.has(e.type)) type2elst.set(e.type, []);
612
- type2elst.get(e.type).push(e);
613
- }
614
- for (const [type, elst] of type2elst) {
615
- listAllEvents(elst, table, j, tk, block, isClickMenu);
616
- }
617
- if (type2elst.size == 0 && Object.keys(j.info).length) {
618
- const [t1, t2] = table.addRow();
619
- t1.text("Diagram");
620
- showJunctionDiagram(j, tk, t2);
621
- }
622
- }
623
- function makeJunctionTerm(j) {
624
- const position = `${j.chr}:${j.start + 1}-${j.stop + 1}`;
625
- return {
626
- type: TermTypes.JUNCTION,
627
- id: `${j.chr}:${j.start}-${j.stop}:${j.strand}`,
628
- name: j.name || `${position} (${j.strand})`,
629
- chr: j.chr,
630
- start: j.start,
631
- stop: j.stop,
632
- strand: j.strand,
633
- info: j.info || {}
634
- };
635
- }
636
- function showJunctionDiagram(j, tk, holder) {
637
- if (typeof j.info != "object" || Object.keys(j.info).length == 0) {
638
- return;
639
- }
640
- const leftgenes = /* @__PURE__ */ new Map();
641
- if (j.info.exonleft) j.info.exonleft.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
642
- if (j.info.exonleftin) j.info.exonleftin.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
643
- if (j.info.intronleft) j.info.intronleft.forEach((i) => leftgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
644
- const rightgenes = /* @__PURE__ */ new Map();
645
- if (j.info.exonright) j.info.exonright.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
646
- if (j.info.exonrightin) j.info.exonrightin.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
647
- if (j.info.intronright) j.info.intronright.forEach((i) => rightgenes.set(i.isoform, { gene: i.gene, strand: i.strand }));
648
- let isoform;
649
- let strand;
650
- if (leftgenes.size) {
651
- if (rightgenes.size) {
652
- for (const [n, a] of leftgenes) {
653
- if (rightgenes.has(n)) {
654
- isoform = n;
655
- strand = a.strand;
656
- break;
657
- }
658
- }
659
- } else {
660
- const a = [...leftgenes][0];
661
- isoform = a[0];
662
- strand = a[1].strand;
663
- }
664
- } else if (rightgenes.size) {
665
- const a = [...rightgenes][0];
666
- isoform = a[0];
667
- strand = a[1].strand;
668
- }
669
- if (isoform) {
670
- if (strand != "+" && strand != "-") {
671
- holder.text("unknown strand for " + isoform);
672
- return;
673
- }
674
- import("./spliceevent.noeventdiagram-CKEWNLVF.js").then((p) => {
675
- p.samegene({
676
- isoform,
677
- reverse: strand == "-",
678
- ongene: j.info,
679
- holder
680
- });
681
- });
682
- return;
683
- }
684
- import("./spliceevent.noeventdiagram-CKEWNLVF.js").then((p) => {
685
- p.differentgenes({
686
- ongene: j.info,
687
- holder
688
- });
689
- });
690
- }
691
- function showEventdiagram_a53ss(j, e, tk, holder, block, isClickMenu) {
692
- const e2 = {
693
- junctionB: {
694
- start: j.start,
695
- stop: j.stop,
696
- strand: j.strand,
697
- v: j.medianReadCount
698
- },
699
- a5ss: e.type == JT_a5ss,
700
- a3ss: e.type == JT_a3ss,
701
- altinintron: e.altinintron,
702
- altinexon: e.altinexon,
703
- frame: e.frame,
704
- exon5idx: e.exon5idx,
705
- strand: e.strand,
706
- sitedist: e.sitedist
707
- };
708
- const otherJs = [];
709
- if (e.junctionA) {
710
- e2.junctionA = { start: e.junctionA.start, stop: e.junctionA.stop, strand: e.junctionA.strand, v: "..." };
711
- const aj = structuredClone(e.junctionA);
712
- aj.name = `E${e.exon5idx + 1}-E${e.exon5idx + 1 + 1}`;
713
- otherJs.push(aj);
714
- }
715
- if (isClickMenu) {
716
- mayGroupSelect(tk, block, j, otherJs, `${e.gene} ${e.isoform} E${e.exon5idx + 1} ${e.type}`, holder);
717
- }
718
- import("./spliceevent.a53ss.diagram-4UBI7PFJ.js").then((p) => {
719
- const text = p.default({
720
- event: e2,
721
- holder
722
- });
723
- if (!text) return;
724
- setTimeout(() => {
725
- if (text.node().getBoundingClientRect().top == 0) return;
726
- const strandA = e.junctionA.strand;
727
- fetchReadcount4junctionAbyjunctionBsamples(
728
- tk,
729
- block,
730
- j,
731
- /* @__PURE__ */ new Map([[e.junctionA.start + "." + e.junctionA.stop + "." + strandA, text]]),
732
- [[e.junctionA.start, e.junctionA.stop, strandA]]
733
- );
734
- }, 1e3);
735
- });
736
- }
737
- function showEventdiagram_skipalt_fetchreadcount(j, e, tk, holder, block, isClickMenu) {
738
- const e2 = {
739
- gm: {
740
- // confirm if can delete
741
- name: e.gene,
742
- isoform: e.isoform
743
- },
744
- junctionB: {
745
- data: [{ v: j.medianReadCount }]
746
- },
747
- skippedexon: e.skippedexon,
748
- isskipexon: e.type == JT_exonskip,
749
- isaltexon: e.type == JT_exonaltuse,
750
- frame: e.frame,
751
- junctionAlst: [],
752
- color: "#99004d"
753
- };
754
- const otherJs = [];
755
- const firstSkipped = Math.min(...e.skippedexon) + 1;
756
- const lastSkipped = Math.max(...e.skippedexon) + 1;
757
- if (e.junctionAlst) {
758
- for (const [i, jA] of e.junctionAlst.entries()) {
759
- if (jA) {
760
- const aj = structuredClone(jA);
761
- aj.name = `E${firstSkipped - 1 + i}-E${firstSkipped + i}`;
762
- otherJs.push(aj);
763
- jA.data = [{ v: "..." }];
764
- e2.junctionAlst.push(jA);
765
- continue;
766
- }
767
- e2.junctionAlst.push(null);
768
- }
769
- }
770
- if (e.up1junction) {
771
- const uj = structuredClone(e.up1junction);
772
- uj.name = `E${firstSkipped - 2}-E${firstSkipped - 1}`;
773
- otherJs.push(uj);
774
- e.up1junction.data = [{ v: "..." }];
775
- e2.up1junction = e.up1junction;
776
- }
777
- if (e.down1junction) {
778
- const dj = structuredClone(e.down1junction);
779
- dj.name = `E${lastSkipped + 1}-E${lastSkipped + 2}`;
780
- otherJs.push(dj);
781
- e.down1junction.data = [{ v: "..." }];
782
- e2.down1junction = e.down1junction;
783
- }
784
- if (isClickMenu) {
785
- const jc = structuredClone({
786
- // duplicate j.info{} just in case
787
- chr: j.chr,
788
- start: j.start,
789
- stop: j.stop,
790
- strand: j.strand,
791
- info: j.info
792
- });
793
- jc.name = `E${firstSkipped - 1}-E${lastSkipped + 1}`;
794
- mayGroupSelect(
795
- tk,
796
- block,
797
- jc,
798
- otherJs,
799
- `${e.gene} ${e.isoform} ${e.skippedexon.map((i) => "E" + (i + 1)).join(",")} ${e.type}`,
800
- holder
801
- );
802
- }
803
- import("./spliceevent.exonskip.diagram-NVEXVRIC.js").then((p) => {
804
- const [junction2readcounttext, junctionlst] = p.default({
805
- event: e2,
806
- holder,
807
- nophrase: true
808
- });
809
- setTimeout(() => {
810
- for (const [k, text] of junction2readcounttext) {
811
- if (text.node().getBoundingClientRect().top == 0) {
812
- return;
813
- }
814
- }
815
- fetchReadcount4junctionAbyjunctionBsamples(tk, block, j, junction2readcounttext, junctionlst);
816
- }, 1e3);
817
- });
818
- }
819
- function mayGroupSelect(tk, block, mainJ, otherJs, eventlabel, holder) {
820
- if (!tk.massApp) return;
821
- for (const j of otherJs) {
822
- j.chr = mainJ.chr;
823
- j.info = {
824
- type: JT_canonical
825
- };
826
- }
827
- holder.append("button").attr("data-testid", "sjpp-junction-select").text(`Select ${otherJs.length + 1} junctions`).on("click", async (event) => {
828
- await addJunctionCustomTerm(
829
- tk,
830
- [makeJunctionTerm(mainJ), ...otherJs.map(makeJunctionTerm)],
831
- event.currentTarget,
832
- msgDiv,
833
- eventlabel
834
- );
835
- });
836
- const msgDiv = holder.append("div").style("font-size", ".7em");
837
- }
838
- async function addJunctionCustomTerm(tk, junctions, button, msgDiv, eventlabel) {
839
- await tk.massApp.dispatch({
840
- type: "add_customTerm",
841
- obj: makeJunctionCustomTerm(junctions, eventlabel)
842
- });
843
- button.remove();
844
- msgDiv.text(
845
- eventlabel ? `${junctions.length} junctions can now be found through variable selection under ${eventlabel}.` : "This junction can now be found through variable selection."
846
- );
847
- }
848
- function listAllEvents(lst, table, j, tk, block, isClickMenu) {
849
- if (lst.length == 1) {
850
- const [t1, t2] = table.addRow();
851
- const e = lst[0];
852
- t1.append("div").text(e.gene);
853
- t1.append("div").text(e.isoform).style("font-size", ".8em");
854
- if (e.type == JT_exonskip || e.type == JT_exonaltuse) {
855
- showEventdiagram_skipalt_fetchreadcount(j, e, tk, t2, block, isClickMenu);
856
- } else if (e.type == JT_a5ss || e.type == JT_a3ss) {
857
- showEventdiagram_a53ss(j, e, tk, t2, block, isClickMenu);
858
- }
859
- return;
860
- }
861
- const map = /* @__PURE__ */ new Map();
862
- for (const e of lst) {
863
- const f = structuredClone(e);
864
- const v = e.isoform;
865
- delete f.isoform;
866
- const key = JSON.stringify(f);
867
- if (map.has(key)) map.get(key).push(e.isoform);
868
- else map.set(key, [e.isoform]);
869
- }
870
- for (const [key, isolst] of map) {
871
- const eo = JSON.parse(key);
872
- eo.isoform = isolst[0];
873
- const [t1, t2] = table.addRow();
874
- t1.append("div").text(eo.gene);
875
- {
876
- const s = isolst.length >= 5 ? 0.7 : 0.8;
877
- for (const i of isolst)
878
- t1.append("div").text(i).style("font-size", s + "em");
879
- }
880
- if (eo.type == JT_exonskip || eo.type == JT_exonaltuse) {
881
- showEventdiagram_skipalt_fetchreadcount(j, eo, tk, t2, block, isClickMenu);
882
- } else if (eo.type == JT_a5ss || eo.type == JT_a3ss) {
883
- showEventdiagram_a53ss(j, eo, tk, t2, block, isClickMenu);
884
- }
885
- }
886
- }
887
- async function fetchReadcount4junctionAbyjunctionBsamples(tk, block, jB, junction2readcounttext, jAlst) {
888
- const [body, headers] = getParameter(tk, block);
889
- delete body.rglst;
890
- delete body.hiddenTypes;
891
- body.junctionB = { chr: jB.chr, start: jB.start, stop: jB.stop, strand: jB.strand };
892
- body.junctionAposlst = jAlst;
893
- try {
894
- const data = await dofetch3("termdb/junctions/AbyB", { body, headers });
895
- if (data.error) throw new Error(data.error);
896
- if (!Array.isArray(data.lst)) throw new Error(".lst[] missing");
897
- for (const j of data.lst) {
898
- const key = j.start + "." + j.stop + "." + j.strand;
899
- if (junction2readcounttext.has(key)) {
900
- junction2readcounttext.get(key).text(j.v);
901
- }
902
- }
903
- } catch (e) {
904
- console.error(e.message || e);
905
- }
906
- }
907
-
908
- // j2/makeTk.js
909
- async function makeTk(tk, block) {
910
- if ("yscaleUseLog" in tk) {
911
- if (typeof tk.yscaleUseLog != "boolean") throw new Error("tk.yscaleUseLog not boolean");
912
- } else {
913
- tk.yscaleUseLog = true;
914
- }
915
- if (tk.hiddentypes) {
916
- if (typeof tk.hiddentypes != "string") throw new Error("tk.hiddentypes not string");
917
- }
918
- if (tk.readcountCutoff) {
919
- if (!Number.isInteger(tk.readcountCutoff) || tk.readcountCutoff < 0)
920
- throw new Error("tk.readcountCutoff is not positive integer");
921
- } else {
922
- tk.readcountCutoff = 0;
923
- }
924
- {
925
- const pale = "#FFFEAB";
926
- const dark = "#F7F69E";
927
- const id1 = Math.random().toString();
928
- const id2 = Math.random().toString();
929
- const id3 = Math.random().toString();
930
- const defs = tk.gleft.append("defs");
931
- const left = defs.append("linearGradient").attr("id", id1);
932
- left.append("stop").attr("offset", 0).attr("stop-color", dark);
933
- left.append("stop").attr("offset", 1).attr("stop-color", "white");
934
- const mid = defs.append("linearGradient").attr("id", id2);
935
- mid.append("stop").attr("offset", 0).attr("stop-color", pale);
936
- mid.append("stop").attr("offset", 0.5).attr("stop-color", "white");
937
- mid.append("stop").attr("offset", 1).attr("stop-color", pale);
938
- const right = defs.append("linearGradient").attr("id", id3);
939
- right.append("stop").attr("offset", 0).attr("stop-color", "white");
940
- right.append("stop").attr("offset", 1).attr("stop-color", dark);
941
- tk.gradient4spanBackground = {
942
- left: { id: id1, gradient: left },
943
- mid: { id: id2, gradient: mid },
944
- right: { id: id3, gradient: right }
945
- };
946
- }
947
- tk.leftlabels = {
948
- // all labels are rendered here, except track label
949
- g: tk.gleft.append("g").attr("transform", "translate(0,17)"),
950
- doms: {},
951
- // keys: label name, value: label dom
952
- // to avoid having to delete all labels upon tk rendering
953
- laby: 0,
954
- // cumulative height, 0 for no labels
955
- xoff: 0,
956
- maxwidth: 0
957
- // set default 0 in case track runs into err, can still render tk
958
- };
959
- tk.leftlabels.doms.jug = makelabel(tk, block, 0);
960
- {
961
- const g = tk.glider.append("g");
962
- tk.sections = {
963
- // sections from top to bottom.
964
- jug: {
965
- height: 0,
966
- // total height of the jug section
967
- g: g.append("g"),
968
- axis: g.append("g"),
969
- yAxisKey: void 0
970
- // key of the junction attribute for y axis, set in renderTk()
971
- }
972
- };
973
- }
974
- setH(tk, "axisheight", 200);
975
- setH(tk, "legheight", 50);
976
- setH(tk, "neckheight", 50);
977
- tk._finish = loadTk_finish_closure(tk, block);
978
- tk.hovertip = new Menu();
979
- tk.itemtip = new Menu();
980
- tk.menutip = new Menu({ padding: "" });
981
- tk.load = _load(tk, block);
982
- if (!tk.custom_data) await initTermdb(tk, block);
983
- if (tk.filter) await Promise.all(rehydrateFilter(tk.filter, tk.vocabApi));
984
- tk.tklabel.text(tk.dslabel || tk.name);
985
- tk.clear = () => {
986
- tk.sections.jug.g.selectAll("*").remove();
987
- };
988
- tk.config_handle = block.maketkconfighandle(tk).on("click", () => {
989
- configPanel(tk, block);
990
- });
991
- initLegend(tk, block);
992
- }
993
- function setH(tk, prop, v) {
994
- const customv = tk[prop];
995
- if (customv != void 0) {
996
- if (!Number.isFinite(customv) || customv <= 0) throw new Error("invalid tk." + prop);
997
- tk.sections.jug[prop] = customv;
998
- delete tk[prop];
999
- return;
1000
- }
1001
- tk.sections.jug[prop] = v;
1002
- }
1003
- function loadTk_finish_closure(tk, block) {
1004
- return (data) => {
1005
- tk.legend?.headTd.text(tk.custom_data ? tk.name : tk.dslabel + (tk.filter ? " - " + getFilterName(tk.filter) : ""));
1006
- if (data) {
1007
- if (data.error) {
1008
- tk.sections.jug.height = 40;
1009
- } else {
1010
- if (data.junctions?.length == 0) {
1011
- tk.sections.jug.g.selectAll("*").remove();
1012
- tk.sections.jug.axis.selectAll("*").remove();
1013
- tk.sections.jug.g.transition().attr("transform", "translate(0,0)");
1014
- tk.sections.jug.g.append("text").text("No splice junctions").attr("y", 25).attr("x", block.width / 2).attr("text-anchor", "middle").attr("dominant-baseline", "center");
1015
- tk.sections.jug.height = 40;
1016
- }
1017
- if (data.alert) {
1018
- console.log("TODO print this alert in tk", data.alert);
1019
- }
1020
- }
1021
- }
1022
- tk.height_main = tk.sections.jug.height + tk.toppad + tk.bottompad;
1023
- if (data) {
1024
- updateLegend(data, tk, block);
1025
- }
1026
- setLeftlabelsMaxWidth(tk);
1027
- tk.leftLabelMaxwidth = tk.leftlabels.maxwidth + tk.leftlabels.xoff, block.tkcloakoff(tk, { error: data ? data.error : null });
1028
- block.block_setheight();
1029
- block.setllabel();
1030
- tk.callbackOnRender?.(tk, block);
1031
- };
1032
- }
1033
- async function initTermdb(tk, block) {
1034
- if (!tk.dslabel) {
1035
- throw new Error("tk.dslabel missing");
1036
- }
1037
- if (!tk.vocabApi) {
1038
- const arg = {
1039
- vocab: {
1040
- genome: block.genome.name,
1041
- dslabel: tk.dslabel
1042
- }
1043
- };
1044
- const _ = await import("./vocabulary-5QBBQAYC.js");
1045
- tk.vocabApi = _.vocabInit(arg);
1046
- if (!tk.vocabApi.app) {
1047
- tk.vocabApi.app = { opts: { genome: block.genome } };
1048
- }
1049
- }
1050
- if (!tk.termdbConfig) {
1051
- tk.termdbConfig = await tk.vocabApi.getTermdbConfig();
1052
- }
1053
- if (!tk.termdbConfig.queries?.junction) throw new Error("queries.junction missing");
1054
- }
1055
- function _load(tk, block) {
1056
- return async () => {
1057
- return await loadTk(tk, block);
1058
- };
1059
- }
1060
- function configPanel(tk, block) {
1061
- tk.tkconfigtip.clear().showunder(tk.config_handle.node());
1062
- const holder = tk.tkconfigtip.d;
1063
- if (!tk.custom_data) {
1064
- const row = holder.append("div").style("margin-bottom", "15px");
1065
- row.append("span").html("Read count cutoff&nbsp;");
1066
- row.append("input").property("value", tk.readcountCutoff || 0).attr("type", "number").style("width", "50px").on("keyup", (event) => {
1067
- if (event.code != "Enter" && event.code != "NumpadEnter") return;
1068
- let v = Number(event.target.value);
1069
- if (!v || v < 0) {
1070
- v = 0;
1071
- }
1072
- if (v == 0) {
1073
- if (tk.readcountCutoff) {
1074
- tk.readcountCutoff = 0;
1075
- loadTk(tk, block, true);
1076
- } else {
1077
- }
1078
- return;
1079
- }
1080
- if (tk.readcountCutoff) {
1081
- if (tk.readcountCutoff == v) {
1082
- } else {
1083
- tk.readcountCutoff = v;
1084
- loadTk(tk, block, true);
1085
- }
1086
- } else {
1087
- tk.readcountCutoff = v;
1088
- loadTk(tk, block, true);
1089
- }
1090
- });
1091
- row.append("div").style("font-size", ".7em").style("color", "#858585").text("For a junction, samples with read count lower than cutoff will not be shown.");
1092
- }
1093
- {
1094
- const k = tk.sections.jug;
1095
- const row = holder.append("div").style("margin-bottom", "15px");
1096
- row.append("span").text("Track height");
1097
- row.append("button").html("&nbsp;&nbsp;+&nbsp;&nbsp;").style("margin-left", "10px").on("click", () => {
1098
- k.axisheight += 30;
1099
- k.legheight = k.axisheight / 4;
1100
- renderTk(null, tk, block);
1101
- block.block_setheight();
1102
- });
1103
- row.append("button").html("&nbsp;&nbsp;-&nbsp;&nbsp;").style("margin-left", "5px").on("click", () => {
1104
- if (k.axisheight <= 90) return;
1105
- k.axisheight -= 30;
1106
- k.legheight = k.axisheight / 4;
1107
- renderTk(null, tk, block);
1108
- block.block_setheight();
1109
- });
1110
- }
1111
- if (tk.sections.jug.yAxisKey == "medianReadCount") {
1112
- const row = holder.append("div").style("margin-bottom", "1px");
1113
- const id = Math.random();
1114
- const input = row.append("input").attr("type", "checkbox").style("margin-right", "10px").attr("id", id).on("change", () => {
1115
- tk.yscaleUseLog = !tk.yscaleUseLog;
1116
- renderTk(null, tk, block);
1117
- });
1118
- if (tk.yscaleUseLog) {
1119
- input.property("checked", 1);
1120
- }
1121
- row.append("label").text("Use log10 for Y scale read count").attr("for", id);
1122
- }
1123
- }
1124
-
1125
- // j2/tk.js
1126
- async function loadTk(tk, block) {
1127
- block.tkcloakon(tk);
1128
- block.block_setheight();
1129
- try {
1130
- if (tk.uninitialized) {
1131
- await makeTk(tk, block);
1132
- delete tk.uninitialized;
1133
- }
1134
- const data = await getTkData(tk, block);
1135
- renderTk(data, tk, block);
1136
- tk._finish(data);
1137
- } catch (e) {
1138
- if (tk.clear) tk.clear();
1139
- if (tk._finish) tk._finish({ error: e.message || e });
1140
- if (e.stack) console.log(e.stack);
1141
- }
1142
- }
1143
- function getParameter(tk, block) {
1144
- const par = {
1145
- genome: block.genome.name,
1146
- dslabel: tk.dslabel,
1147
- filter0: tk.filter0,
1148
- filter: tk.filter,
1149
- readcountCutoff: tk.readcountCutoff
1150
- };
1151
- const headers = { "Content-Type": "application/json", Accept: "application/json" };
1152
- rangequery_rglst(tk, block, par);
1153
- if (tk.legend?.type?.hiddenvalues?.size) par.hiddenTypes = [...tk.legend.type.hiddenvalues].join(",");
1154
- return [par, headers];
1155
- }
1156
- async function getTkData(tk, block) {
1157
- let data;
1158
- if (tk.custom_data) {
1159
- data = await dataFromCustomData(tk, block);
1160
- } else {
1161
- const [body, headers] = getParameter(tk, block);
1162
- data = await dofetch3("termdb/junctions", { body, headers });
1163
- }
1164
- if (data.error) throw new Error(data.error);
1165
- return data;
1166
- }
1167
- async function dataFromCustomData(tk, block) {
1168
- const hidden = tk.legend?.type?.hiddenvalues;
1169
- const junctions = tk.custom_data.flatMap((j) => {
1170
- if (typeof j.chr != "string" || !Number.isInteger(j.start) || !Number.isInteger(j.stop))
1171
- throw new Error("custom junction requires chr, start and stop");
1172
- const types = (j.types || []).filter((t) => !hidden?.has(t));
1173
- if (j.types?.length && !types.length) return [];
1174
- const info = { ...j.info };
1175
- if (info.events) {
1176
- info.events = info.events.filter((e) => !hidden?.has(e.type));
1177
- if (!info.events.length) delete info.events;
1178
- }
1179
- const j2 = { ...j, types, info };
1180
- if (j.sv) j2.sv = { ...j.sv, mate: { ...j.sv.mate } };
1181
- if (Number.isFinite(j.p)) j2.negLog10p = -Math.log10(Math.max(j.p, Number.MIN_VALUE));
1182
- return [j2];
1183
- });
1184
- const data = { junctions };
1185
- if (junctions.every((j) => Number.isFinite(j.medianReadCount)))
1186
- data.maxReadCount = Math.max(...junctions.map((j) => j.medianReadCount));
1187
- return data;
1188
- }
1189
- export {
1190
- getParameter,
1191
- loadTk
1192
- };
1193
- //# sourceMappingURL=tk-P3RPLUVH.js.map