@sjcrh/proteinpaint-client 2.220.0 → 2.222.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (864) hide show
  1. package/dist/2dmaf-QFXSYOYN.js +1362 -0
  2. package/dist/AggMatrixInput-7D4ZUYJK.js +402 -0
  3. package/dist/AggregateMatrix-NVSFZEW3.js +37 -0
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  5. package/dist/BoxPlot-52WWBGKN.js +1229 -0
  6. package/dist/CorrelationVolcano-WS23O2JT.js +613 -0
  7. package/dist/Cuminc-5LJQYFEE.js +1217 -0
  8. package/dist/DE-Z5GBDXDU.js +85 -0
  9. package/dist/DEinput-3EAIVG5U.js +479 -0
  10. package/dist/DM-24NZPPS6.js +86 -0
  11. package/dist/DifferentialAnalysis-LRAPDIXB.js +236 -0
  12. package/dist/Disco-IDOTCKSD.js +3384 -0
  13. package/dist/Disco.UI-SLJKAA6N.js +239 -0
  14. package/dist/DmrPlot-5CRGQNM3.js +361 -0
  15. package/dist/GB-YCDIORF3.js +1388 -0
  16. package/dist/GSEA-IGWX3AG7.js +870 -0
  17. package/dist/GeneExpInput-PPOTCILZ.js +38 -0
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  37. package/dist/ProteomeInput-KB7YRARQ.js +610 -0
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  143. package/dist/cohort-CI22KICX.js +66 -0
  144. package/dist/cohortSunburst-Z5DANXVS.js +402 -0
  145. package/dist/condition-GZOA7BZJ.js +323 -0
  146. package/dist/controls-OWC25VQN.js +30 -0
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  148. package/dist/correlation-EBA5YVXA.js +91 -0
  149. package/dist/customdata.inputui-FZRZCPS3.js +280 -0
  150. package/dist/dataDownload-WIPQU33P.js +326 -0
  151. package/dist/databrowser.ui-6L6Q72W4.js +421 -0
  152. package/dist/dictionary-4VZEPGW5.js +109 -0
  153. package/dist/dnaMethylation-LN6THRNZ.js +29 -0
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  161. package/dist/geneExpression-FOQOKD34.js +29 -0
  162. package/dist/geneExpression.unit.spec-XSFC5ZJP.js +151 -0
  163. package/dist/geneORA-KYPN66QU.js +269 -0
  164. package/dist/geneRanking-VEHFMRFL.js +544 -0
  165. package/dist/geneVariant-77V6FNJX.js +289 -0
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  168. package/dist/genefusion.ui-YNVTTLDE.js +299 -0
  169. package/dist/geneset-BH5MWNJQ.js +199 -0
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  806. /package/dist/{singleCellGeneExpression.unit.spec-JVHPFLML.js.map → singleCellGeneExpression.unit.spec-N3VD6PUW.js.map} +0 -0
  807. /package/dist/{singleCellNumericValue-FHIECJDK.js.map → singleCellNumericValue-W6F44FJN.js.map} +0 -0
  808. /package/dist/{singleCellNumericValue.unit.spec-ZFG56MIO.js.map → singleCellNumericValue.unit.spec-JZNMY77I.js.map} +0 -0
  809. /package/dist/{singleCellPlot-NDGIW32L.js.map → singleCellPlot-CCG2KSCO.js.map} +0 -0
  810. /package/dist/{singlecell-JPWVPZEF.js.map → singlecell-32P47E4I.js.map} +0 -0
  811. /package/dist/{singlecell-N7RJMWZ2.js.map → singlecell-I6H3Z7FT.js.map} +0 -0
  812. /package/dist/{snp-APUTOL2F.js.map → snp-7X2BXRQP.js.map} +0 -0
  813. /package/dist/{snp.unit.spec-4AN7AJKO.js.map → snp.unit.spec-BJGWNSVR.js.map} +0 -0
  814. /package/dist/{snplocus-WIMFAMBE.js.map → snplocus-UOVS2GD6.js.map} +0 -0
  815. /package/dist/{snplst-SUJ5AK4E.js.map → snplst-JFVP4NG2.js.map} +0 -0
  816. /package/dist/{spliceevent.a53ss.diagram-4UBI7PFJ.js.map → spliceevent.a53ss.diagram-ETXJX57W.js.map} +0 -0
  817. /package/dist/{spliceevent.exonskip.diagram-NVEXVRIC.js.map → spliceevent.exonskip.diagram-C4JCEOXQ.js.map} +0 -0
  818. /package/dist/{spliceevent.noeventdiagram-CKEWNLVF.js.map → spliceevent.noeventdiagram-4DD3Z4OM.js.map} +0 -0
  819. /package/dist/{ssGSEA-CJOVXTAW.js.map → ssGSEA-GOZOYROM.js.map} +0 -0
  820. /package/dist/{ssGSEA.unit.spec-A7VRVJSF.js.map → ssGSEA.unit.spec-J4DPFU4D.js.map} +0 -0
  821. /package/dist/{stattable-JBJVVLQE.js.map → stattable-ICUZQHUF.js.map} +0 -0
  822. /package/dist/{studyCatalog-NEL7XSIP.js.map → studyCatalog-PCFXVOI3.js.map} +0 -0
  823. /package/dist/{summarizeCnvGeneexp-BZSCTA5W.js.map → summarizeCnvGeneexp-DK6HNUFE.js.map} +0 -0
  824. /package/dist/{summarizeGeneexpSurvival-743KXNV7.js.map → summarizeGeneexpSurvival-JLCR2VIX.js.map} +0 -0
  825. /package/dist/{summarizeMutationCnv-CALMSQGV.js.map → summarizeMutationCnv-CFAKT6IP.js.map} +0 -0
  826. /package/dist/{summarizeMutationDiagnosis-OTE7O4AS.js.map → summarizeMutationDiagnosis-5HMVSYMI.js.map} +0 -0
  827. /package/dist/{summarizeMutationSurvival-VOZOFTFM.js.map → summarizeMutationSurvival-GP2OQMUS.js.map} +0 -0
  828. /package/dist/{summary-XJKCD35N.js.map → summary-6K553VNS.js.map} +0 -0
  829. /package/dist/{summary.integration.spec-OOEU6WNB.js.map → summary.integration.spec-MXERZOVY.js.map} +0 -0
  830. /package/dist/{summaryInput-JSOXVSMY.js.map → summaryInput-V2G6HFJS.js.map} +0 -0
  831. /package/dist/{sunburst-J3QHMYKW.js.map → sunburst-6GKVNIRF.js.map} +0 -0
  832. /package/dist/{sunburst-LZPP6NPV.js.map → sunburst-YOVKC5G2.js.map} +0 -0
  833. /package/dist/{survival-FW7N3YXZ.js.map → survival-GHTV2ZPX.js.map} +0 -0
  834. /package/dist/{survival-5GWRVTQ6.js.map → survival-KF2QUWSM.js.map} +0 -0
  835. /package/dist/{survival.integration.spec-WN36VUHL.js.map → survival.integration.spec-GVSQL4VB.js.map} +0 -0
  836. /package/dist/{svgraph-N35EMK3G.js.map → svgraph-WN3JLEOC.js.map} +0 -0
  837. /package/dist/{svmr-EWL5WDDD.js.map → svmr-ZZKBQFQK.js.map} +0 -0
  838. /package/dist/{swimmer-Z6FUH4CD.js.map → swimmer-XHORJEVI.js.map} +0 -0
  839. /package/dist/{table-EI2OIRGE.js.map → table-XQCTNHSZ.js.map} +0 -0
  840. /package/dist/{termCollection-K3EX5P3F.js.map → termCollection-DXZQT7YT.js.map} +0 -0
  841. /package/dist/{termCollection-TBTAHLVH.js.map → termCollection-HRM2NHLA.js.map} +0 -0
  842. /package/dist/{termCollection.unit.spec-ZVNAIPHZ.js.map → termCollection.unit.spec-BGULSLH6.js.map} +0 -0
  843. /package/dist/{termCollectionFractionSelection-ATNIPWVX.js.map → termCollectionFractionSelection-TPNNP2ER.js.map} +0 -0
  844. /package/dist/{termCollectionFractionSelection.unit.spec-VBRWWBML.js.map → termCollectionFractionSelection.unit.spec-VONXAGZH.js.map} +0 -0
  845. /package/dist/{tk-P3RPLUVH.js.map → tk-KPD6HTHR.js.map} +0 -0
  846. /package/dist/{tk-U6CYISBH.js.map → tk-RCTQPQH7.js.map} +0 -0
  847. /package/dist/{tp.ui-KBFYUSWS.js.map → tp.ui-MVNQLMAD.js.map} +0 -0
  848. /package/dist/{tvs.categorical-5USP772O.js.map → tvs.categorical-4TKKU6HO.js.map} +0 -0
  849. /package/dist/{tvs.condition-652MAA2Z.js.map → tvs.condition-SARY3O5Y.js.map} +0 -0
  850. /package/dist/{tvs.density-CB24PXDE.js.map → tvs.density-IGO4I4T2.js.map} +0 -0
  851. /package/dist/{tvs.dt-7BTARQUS.js.map → tvs.dt-XJ2MW2AP.js.map} +0 -0
  852. /package/dist/{tvs.dtcnv.categorical-GAOO3DGO.js.map → tvs.dtcnv.categorical-H7FKTXH4.js.map} +0 -0
  853. /package/dist/{tvs.dtcnv.continuous-P2QRD45O.js.map → tvs.dtcnv.continuous-JQ62ZHER.js.map} +0 -0
  854. /package/dist/{tvs.dtfusion-L3I65W7L.js.map → tvs.dtfusion-GC3DZ2BO.js.map} +0 -0
  855. /package/dist/{tvs.dtitd-B3JPW6OL.js.map → tvs.dtitd-3SHGIDIB.js.map} +0 -0
  856. /package/dist/{tvs.dtsnvindel-6Y6CJBZV.js.map → tvs.dtsnvindel-BEDWZ4A2.js.map} +0 -0
  857. /package/dist/{tvs.dtsv-GL7CPATL.js.map → tvs.dtsv-HRIMULVD.js.map} +0 -0
  858. /package/dist/{tvs.multivalue-75IM23FZ.js.map → tvs.multivalue-5VC7BLSZ.js.map} +0 -0
  859. /package/dist/{tvs.numeric-XB3GBPHE.js.map → tvs.numeric-TGEC7G6A.js.map} +0 -0
  860. /package/dist/{tvs.samplelst-QUA45UE7.js.map → tvs.samplelst-Q6EYAUQZ.js.map} +0 -0
  861. /package/dist/{tvs.survival-EKSDZZIO.js.map → tvs.survival-NJ3DTZIG.js.map} +0 -0
  862. /package/dist/{tvs.termCollection-5ATMDC7O.js.map → tvs.termCollection-TVVLPSTG.js.map} +0 -0
  863. /package/dist/{vocabulary-5QBBQAYC.js.map → vocabulary-A7ZBBU65.js.map} +0 -0
  864. /package/dist/{wsi.direct-BU6BL5UR.js.map → wsi.direct-JJGIAH6A.js.map} +0 -0
@@ -1,2240 +0,0 @@
1
- import {
2
- blocklazyload
3
- } from "./chunk-XP4P55IC.js";
4
- import {
5
- hicParseFile
6
- } from "./chunk-FJ2JV2VK.js";
7
- import {
8
- AppBase,
9
- ColorScale,
10
- axisstyle,
11
- first_genetrack_tolist,
12
- font,
13
- newpane,
14
- showErrorsWithCounter,
15
- tkt
16
- } from "./chunk-PEKCVKJK.js";
17
- import "./chunk-HJ6L54YS.js";
18
- import "./chunk-YR6EXI2K.js";
19
- import {
20
- Menu
21
- } from "./chunk-CNFTQSNE.js";
22
- import "./chunk-RIHO7ZD5.js";
23
- import "./chunk-TVJOSRCH.js";
24
- import "./chunk-3CIL7KH7.js";
25
- import "./chunk-T4XPCSLP.js";
26
- import {
27
- dofetch3
28
- } from "./chunk-4TJO2DGU.js";
29
- import "./chunk-W5J3LTYS.js";
30
- import "./chunk-MHWYRNGA.js";
31
- import "./chunk-JHLF2ZC2.js";
32
- import {
33
- axisBottom,
34
- axisRight,
35
- bplen
36
- } from "./chunk-WJLRU5OF.js";
37
- import {
38
- StoreBase,
39
- getAppInit,
40
- getCompInit,
41
- getStoreInit
42
- } from "./chunk-HBNB5TRH.js";
43
- import "./chunk-PF4DSFDR.js";
44
- import {
45
- format,
46
- linear
47
- } from "./chunk-4OLM3KSB.js";
48
- import "./chunk-6XKAOSQE.js";
49
- import "./chunk-TLT4YIG3.js";
50
- import "./chunk-5R63Q5KH.js";
51
- import {
52
- pointer_default,
53
- select_default
54
- } from "./chunk-I6Y4O3RR.js";
55
- import "./chunk-Q5RDQNIT.js";
56
- import "./chunk-HS5PO5ZQ.js";
57
-
58
- // tracks/hic/HicStore.ts
59
- var HicStore = class _HicStore extends StoreBase {
60
- constructor(opts) {
61
- super(opts);
62
- this.views = ["genome", "chrpair", "detail", "horizontal"];
63
- this.type = _HicStore.type;
64
- this.defaultState = {
65
- defaultNmeth: "NONE",
66
- loading: true,
67
- minBinNum_bp: 200,
68
- minFragSpan: 200,
69
- initialBinNum: 20,
70
- settings: {
71
- widthHeightPx: 800
72
- }
73
- };
74
- }
75
- static {
76
- this.type = "store";
77
- }
78
- init() {
79
- this.state = Object.assign({}, this.defaultState, this.state);
80
- }
81
- };
82
- var hicStoreInit = getStoreInit(HicStore);
83
- HicStore.prototype.actions = {
84
- view_create(action) {
85
- if (!action.view) throw Error("view_create: missing view");
86
- if (!this.views.some((v) => v == action.view)) throw Error(`view_create: unknown view = ${action.view}`);
87
- this.state.currView = action.view;
88
- const opts = Object.assign(this.state, action.config);
89
- this.state = opts;
90
- },
91
- view_update(action) {
92
- if (action.view) {
93
- if (!this.views.some((v) => v == action.view)) throw Error(`view_update: unknown view = ${action.view}`);
94
- const opts = Object.assign(this.state[action.view], action.config);
95
- this.state[action.view] = opts;
96
- } else {
97
- const opts = Object.assign(this.state, action.config);
98
- this.state = opts;
99
- }
100
- },
101
- loading_active(action) {
102
- this.state.loading = action.active;
103
- }
104
- };
105
-
106
- // tracks/hic/dom/LoadingOverlay.ts
107
- var LoadingOverlay = class _LoadingOverlay {
108
- constructor(opts) {
109
- this.hasStatePreMain = true;
110
- this.type = _LoadingOverlay.type;
111
- this.app = opts.app;
112
- this.loadingDiv = opts.loadingDiv;
113
- }
114
- static {
115
- this.type = "loadingOverlay";
116
- }
117
- reactsTo(action) {
118
- if (action.type.startsWith("loading")) return true;
119
- else return false;
120
- }
121
- getState(appState) {
122
- return appState;
123
- }
124
- init() {
125
- this.loadingDiv.append("div").attr("class", "sjpp-spinner").style("display", "");
126
- }
127
- main(appState) {
128
- const loading = this.app.getState(appState).loading;
129
- this.loadingDiv.style("display", loading ? "" : "none");
130
- }
131
- };
132
- var loadingInit = getCompInit(LoadingOverlay);
133
-
134
- // tracks/hic/dom/ColorizeElement.ts
135
- var ColorizeElement = class {
136
- colorizeElement(xCoord, yCoord, v, obj, width, height, bpMinV, bpMaxV, currView) {
137
- if (v >= 0) {
138
- const p = v >= bpMaxV ? 0 : v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV - v) / bpMaxV);
139
- const positiveFill = `rgb(255, ${p}, ${p})`;
140
- if (currView === "genome") {
141
- obj.ctx.fillStyle = positiveFill;
142
- obj.ctx2.fillStyle = positiveFill;
143
- } else {
144
- obj.fillStyle = positiveFill;
145
- }
146
- } else {
147
- const p = v <= bpMinV ? 255 : Math.floor(255 * (bpMaxV + v) / bpMaxV);
148
- const negativeFill = `rgb(${p}, ${p}, 255)`;
149
- if (currView === "genome") {
150
- obj.ctx.fillStyle = negativeFill;
151
- obj.ctx2.fillStyle = negativeFill;
152
- } else {
153
- obj.fillStyle = negativeFill;
154
- }
155
- }
156
- if (currView === "genome") {
157
- obj.ctx.fillRect(yCoord, xCoord, width, height);
158
- obj.ctx2.fillRect(xCoord, yCoord, width, height);
159
- } else {
160
- obj.fillRect(xCoord, yCoord, width, height);
161
- }
162
- }
163
- };
164
-
165
- // tracks/hic/data/Resolution.ts
166
- var Resolution = class {
167
- constructor(error) {
168
- this.error = error;
169
- }
170
- getResolution(state, hic) {
171
- if (state.currView == "genome") return hic["bpresolution"][0];
172
- if (state.currView == "chrpair") {
173
- const resolution = this.getChrPairResolution(hic, state.x, state.y, state.minBinNum_bp);
174
- return resolution;
175
- } else if (state.currView == "detail") {
176
- const maxBpWidth = Math.max(state.x.stop - state.x.start, state.y.stop - state.y.start);
177
- let resolution = this.findResFromArray(maxBpWidth, state.minBinNum_bp, hic.bpresolution);
178
- if (resolution == null && !hic.enzyme) {
179
- resolution = hic.bpresolution[hic.bpresolution.length - 1];
180
- }
181
- return resolution;
182
- } else {
183
- this.error(`Unknown view: ${state.currView}`);
184
- throw `Unknown view: ${state.currView}`;
185
- }
186
- }
187
- getChrPairResolution(hic, x, y, minBinNum_bp) {
188
- const chrxlen = hic.genome.chrlookup[x.chr.toUpperCase()].len;
189
- const chrylen = hic.genome.chrlookup[y.chr.toUpperCase()].len;
190
- const maxchrlen = Math.max(chrxlen, chrylen);
191
- const resolution = this.findResFromArray(maxchrlen, minBinNum_bp, hic.bpresolution);
192
- if (resolution == null) {
193
- this.error(`No suitable resolution for ${x.chr}-${y.chr} pair.`);
194
- return;
195
- }
196
- return resolution;
197
- }
198
- findResFromArray(max, defaultValue, resolutionArray, returnNum) {
199
- let resolution = null;
200
- for (const res of resolutionArray) {
201
- if (max / res > defaultValue) {
202
- resolution = res;
203
- break;
204
- }
205
- }
206
- if (returnNum && resolution == null) {
207
- resolution = resolutionArray[resolutionArray.length - 1];
208
- }
209
- return resolution;
210
- }
211
- getDefaultViewSpan(hic, x, y, initialBinNum, minBinNum_bp) {
212
- const chrpairResolution = this.getChrPairResolution(hic, x, y, minBinNum_bp);
213
- if (!chrpairResolution) return;
214
- return chrpairResolution * initialBinNum;
215
- }
216
- };
217
-
218
- // tracks/hic/data/Positions.ts
219
- var Positions = class {
220
- constructor(error, minBinNum_bp) {
221
- this.error = error;
222
- this.resolution = new Resolution(this.error);
223
- this.minBinNum_bp = minBinNum_bp;
224
- }
225
- /**
226
- *
227
- * @param x x coordinate of pointer
228
- * @param y y coordinate of pointer
229
- * @param binpx
230
- * @param chrx x chr from state
231
- * @param chry y chr from state
232
- * @param hic
233
- * @param initialBinNum Set in the state
234
- * @returns
235
- */
236
- setPosition(x, y, binpx, chrx, chry, hic, initialBinNum) {
237
- const resolution = this.resolution.getChrPairResolution(hic, chrx, chry, this.minBinNum_bp);
238
- const viewrangebpw = resolution * initialBinNum;
239
- let coordx = Math.max(1, Math.floor(x * resolution / binpx) - viewrangebpw / 2);
240
- let coordy = Math.max(1, Math.floor(y * resolution / binpx) - viewrangebpw / 2);
241
- {
242
- const lenx = hic.genome.chrlookup[chrx.chr.toUpperCase()].len;
243
- if (coordx + viewrangebpw >= lenx) {
244
- coordx = lenx - viewrangebpw;
245
- }
246
- const leny = hic.genome.chrlookup[chry.chr.toUpperCase()].len;
247
- if (coordy + viewrangebpw > leny) {
248
- coordy = leny - viewrangebpw;
249
- }
250
- }
251
- const xObj = {
252
- chr: chrx.chr,
253
- start: coordx,
254
- stop: coordx + viewrangebpw
255
- };
256
- const yObj = {
257
- chr: chry.chr,
258
- start: coordy,
259
- stop: coordy + viewrangebpw
260
- };
261
- return [xObj, yObj];
262
- }
263
- };
264
-
265
- // tracks/hic/data/GridElementsFormattedData.ts
266
- var GridElementsFormattedData = class {
267
- /**
268
- * Format the data for the grid elements.
269
- * @param items The data to format.
270
- * @param binpx The bin size in pixels.
271
- * @param resolution The resolution.
272
- * @param isFirstChrX Whether the first chromosome is X. Used for chrpair view.
273
- * @param isIntraChr Whether the data is intra-chromosomal. Used for chrpair view
274
- * @returns The formatted data.
275
- */
276
- formatData(view, items, binpx, resolution, isFirstChrX, isIntraChr) {
277
- const formattedData = [];
278
- for (const [xCoord, yCoord, value] of items) {
279
- const xPx = Math.floor(xCoord / resolution) * binpx;
280
- const yPx = Math.floor(yCoord / resolution) * binpx;
281
- if (view == "genome") {
282
- formattedData.push([xPx, yPx, value]);
283
- }
284
- if (view == "chrpair") {
285
- const x = isFirstChrX ? xPx : yPx;
286
- const y = isFirstChrX ? yPx : xPx;
287
- formattedData.push([x, y, value]);
288
- if (isIntraChr) {
289
- formattedData.push([y, x, value]);
290
- }
291
- }
292
- }
293
- return formattedData;
294
- }
295
- };
296
-
297
- // tracks/hic/data/FirstChrX.ts
298
- var FirstChrX = class {
299
- constructor(chrorder, chrx, chry) {
300
- this.chrorder = chrorder;
301
- this.chrx = chrx;
302
- this.chry = chry;
303
- }
304
- isFirstX() {
305
- if (this.chrx == this.chry) return true;
306
- return this.chrorder.indexOf(this.chrx) < this.chrorder.indexOf(this.chry);
307
- }
308
- };
309
-
310
- // tracks/hic/chrpair/ChrPairView.ts
311
- var ChrPairView = class {
312
- constructor(opts) {
313
- this.binpx = 1;
314
- /** padding on the ends of x/y chr coordinate axes */
315
- this.axispad = 10;
316
- this.axisLabelFontSize = 15;
317
- this.calcResolution = null;
318
- this.data = [];
319
- this.app = opts.app;
320
- this.hic = opts.hic;
321
- this.plotDiv = opts.plotDiv;
322
- this.items = opts.items;
323
- this.parent = opts.parent;
324
- this.chrxlen = this.hic.genome.chrlookup[this.parent("state").x.chr.toUpperCase()].len;
325
- this.chrylen = this.hic.genome.chrlookup[this.parent("state").y.chr.toUpperCase()].len;
326
- this.maxchrlen = Math.max(this.chrxlen, this.chrylen);
327
- this.colorizeElement = new ColorizeElement();
328
- this.positions = new Positions(opts.error, this.parent("state").minBinNum_bp);
329
- this.formattedData = new GridElementsFormattedData();
330
- }
331
- setDefaultBinpx() {
332
- if (this.calcResolution == null) return;
333
- while (this.binpx * this.maxchrlen / this.calcResolution < 600) {
334
- this.binpx++;
335
- }
336
- }
337
- renderAxes() {
338
- if (this.calcResolution == null) return;
339
- const svgY = this.plotDiv.yAxis.append("svg");
340
- const h = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
341
- svgY.attr("width", 100).attr("height", this.axispad * 2 + h);
342
- svgY.append("g").attr("data-testid", "sjpp-chrpair-svg-y").attr("transform", "translate(80," + (this.axispad + h / 2) + ")").append("text").text(this.parent("state").y.chr).attr("text-anchor", "middle").attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("dominant-baseline", "central").attr("transform", "rotate(90)");
343
- axisstyle({
344
- axis: svgY.append("g").attr("transform", `translate(1, ${this.axispad})`).call(axisRight(linear().domain([0, this.chrylen]).range([0, h])).tickFormat(format(".2s"))),
345
- showline: true
346
- });
347
- const svgX = this.plotDiv.xAxis.append("svg").style("margin-top", "-4px");
348
- const w = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
349
- svgX.attr("height", 100).attr("width", this.axispad * 2 + w);
350
- svgX.append("text").attr("data-testid", "sjpp-chrpair-svg-x").text(this.parent("state").x.chr).attr("font-size", this.axisLabelFontSize).attr("font-family", font).attr("x", this.axispad + w / 2).attr("text-anchor", "middle").attr("y", 60);
351
- axisstyle({
352
- axis: svgX.append("g").attr("transform", "translate(" + this.axispad + ",1)").call(axisBottom(linear().domain([0, this.chrxlen]).range([0, w])).tickFormat(format(".2s"))),
353
- showline: true
354
- });
355
- }
356
- renderCanvas() {
357
- const initDetailView = this.initDetailView.bind(this);
358
- this.canvas = this.plotDiv.plot.append("canvas").attr("data-testid", "sjpp-chrpair-canvas").style("margin", this.axispad + "px").on("click", async function(event) {
359
- const [x, y] = pointer_default(event, this);
360
- initDetailView(x, y);
361
- }).node();
362
- this.canvas.width = Math.ceil(this.chrxlen / this.calcResolution) * this.binpx;
363
- this.canvas.height = Math.ceil(this.chrylen / this.calcResolution) * this.binpx;
364
- this.ctx = this.canvas.getContext("2d");
365
- }
366
- initDetailView(x, y) {
367
- const [xObj, yObj] = this.positions.setPosition(
368
- x,
369
- y,
370
- this.binpx,
371
- this.parent("state").x,
372
- this.parent("state").y,
373
- this.hic,
374
- this.parent("state").initialBinNum
375
- );
376
- this.app.dispatch({
377
- type: "view_create",
378
- view: "detail",
379
- config: {
380
- x: xObj,
381
- y: yObj
382
- }
383
- });
384
- }
385
- render() {
386
- this.calcResolution = this.parent("calcResolution");
387
- this.setDefaultBinpx();
388
- this.renderAxes();
389
- this.renderCanvas();
390
- this.update(this.items);
391
- }
392
- update(items) {
393
- this.items = items;
394
- const firstisx = new FirstChrX(this.hic.chrorder, this.parent("state").x.chr, this.parent("state").y.chr).isFirstX();
395
- const isintrachr = this.parent("state").x.chr === this.parent("state").y.chr;
396
- this.data = this.formattedData.formatData(
397
- "chrpair",
398
- items.items,
399
- this.binpx,
400
- this.calcResolution,
401
- firstisx,
402
- isintrachr
403
- );
404
- this.ctx.clearRect(0, 0, this.canvas.width, this.canvas.height);
405
- for (const [x, y, v] of this.data) {
406
- this.colorizeElement.colorizeElement(
407
- x,
408
- y,
409
- v,
410
- this.ctx,
411
- this.binpx,
412
- //width
413
- this.binpx,
414
- //height
415
- this.parent("min"),
416
- this.parent("max"),
417
- "chrpair"
418
- );
419
- }
420
- this.app.dispatch({ type: "loading_active", active: false });
421
- }
422
- };
423
-
424
- // tracks/hic/horizontal/HorizontalView.ts
425
- var HorizontalView = class {
426
- constructor(opts) {
427
- /** Defaults*/
428
- this.maxPercentage = 5;
429
- this.subPanelPxWidth = 600;
430
- this.borderColor = "rgba(200,0,0,.1)";
431
- this.app = opts.app;
432
- this.hic = opts.hic;
433
- this.plotDiv = opts.plotDiv;
434
- this.items = opts.items;
435
- this.parent = opts.parent;
436
- }
437
- setRunPpTracks() {
438
- const tracks = [
439
- {
440
- type: "hicstraw",
441
- file: this.hic.file,
442
- url: this.hic.url,
443
- name: this.hic.name,
444
- enzyme: this.hic.enzyme,
445
- maxpercentage: this.maxPercentage,
446
- pyramindup: 1
447
- }
448
- ];
449
- if (this.hic.tklst) {
450
- for (const t of this.hic.tklst) {
451
- tracks.push(t);
452
- }
453
- }
454
- first_genetrack_tolist(this.hic.genome, tracks);
455
- return tracks;
456
- }
457
- setRunPpArgs(tracks) {
458
- const arg = {
459
- holder: this.plotDiv.plot,
460
- hostURL: this.hic.hostURL,
461
- jwt: this.hic.jwt,
462
- genome: this.hic.genome,
463
- nobox: 1,
464
- tklst: tracks
465
- };
466
- const state = this.parent("state");
467
- if (state.x.chr == state.y.chr && Math.max(state.x.start, state.y.start) < Math.min(state.x.stop, state.y.stop)) {
468
- arg["chr"] = state.x.chr;
469
- arg["start"] = Math.min(state.x.start, state.y.start);
470
- arg["stop"] = Math.max(state.x.stop, state.y.stop);
471
- } else {
472
- arg["chr"] = state.x.chr;
473
- arg["start"] = state.x.start;
474
- arg["stop"] = state.x.stop;
475
- arg["width"] = this.subPanelPxWidth;
476
- arg["subpanels"] = [
477
- {
478
- chr: state.y.chr,
479
- start: state.y.start,
480
- stop: state.y.stop,
481
- width: this.subPanelPxWidth,
482
- leftpad: 10,
483
- leftborder: this.borderColor
484
- }
485
- ];
486
- }
487
- return arg;
488
- }
489
- render() {
490
- const tracks = this.setRunPpTracks();
491
- const arg = this.setRunPpArgs(tracks);
492
- blocklazyload(arg);
493
- }
494
- // update() {
495
- // //Not required.
496
- // //If controls are added back. Implement changes here.
497
- // }
498
- };
499
-
500
- // tracks/hic/detail/DetailBlock.ts
501
- var DetailBlock = class {
502
- constructor(app, hic, blockwidth, bbmargin, holder, isYblock) {
503
- /** Defaults */
504
- this.leftheadw = 20;
505
- this.rightheadw = 40;
506
- this.lpad = 1;
507
- this.rpad = 1;
508
- this.firstRender = true;
509
- this.app = app;
510
- this.hic = hic;
511
- this.width = blockwidth;
512
- this.bbmargin = bbmargin;
513
- this.holder = holder;
514
- this.isYblock = isYblock;
515
- this.bbw = this.leftheadw + this.lpad + this.width + this.rpad + this.rightheadw + 2 * this.bbmargin;
516
- this.defaultLeft = this.bbmargin + this.leftheadw + this.lpad;
517
- this.defaultTop = this.bbmargin + this.rightheadw + this.rpad;
518
- }
519
- setArgs(chrObj) {
520
- const runPpArgs = {
521
- hostURL: this.hic.hostURL,
522
- genome: this.hic.genome,
523
- holder: this.holder,
524
- noresize: true,
525
- nobox: true,
526
- butrowbottom: true,
527
- style: {
528
- margin: `${this.bbmargin}px`
529
- },
530
- width: this.width,
531
- leftheadw: this.leftheadw,
532
- chr: chrObj.chr,
533
- start: chrObj.start,
534
- stop: chrObj.stop,
535
- rightheadw: this.rightheadw,
536
- tklst: [],
537
- rotated: this.isYblock,
538
- showreverse: this.isYblock
539
- };
540
- first_genetrack_tolist(this.hic.genome, runPpArgs.tklst);
541
- return runPpArgs;
542
- }
543
- setMethods(canvasHolder, canvas, sheath) {
544
- const runPpMethods = {
545
- onloadalltk_always: () => {
546
- this.onload(canvasHolder, canvas, sheath);
547
- },
548
- onpanning: (xoff) => this.onpanning(xoff, canvas)
549
- };
550
- if (this.isYblock) {
551
- runPpMethods["onsetheight"] = (bbh) => {
552
- this.holder.transition().style("left", `${bbh + this.bbmargin + 30}px`);
553
- };
554
- }
555
- return runPpMethods;
556
- }
557
- onload(canvasHolder, canvas, sheath) {
558
- this.bbw = this.block.leftheadw + this.block.lpad + this.block.width + this.block.rpad + this.block.rightheadw + 2 * this.bbmargin;
559
- if (this.isYblock) {
560
- sheath.transition().style("height", `${this.bbw}px`);
561
- canvasHolder.style("height", `${this.bbw}px`);
562
- } else canvasHolder.style("width", `${this.bbw}px`);
563
- if (this.isYblock) {
564
- this.defaultTop = this.bbmargin + this.block.rightheadw + this.block.rpad;
565
- canvas.style("top", `${this.defaultTop}px`);
566
- } else {
567
- this.defaultLeft = this.bbmargin + this.block.leftheadw + this.block.lpad;
568
- canvas.style("left", `${this.defaultLeft}px`);
569
- }
570
- const config = {
571
- [this.isYblock ? "y" : "x"]: {
572
- chr: this.block.rglst[0].chr,
573
- start: this.block.rglst[0].start,
574
- stop: this.block.rglst[0].stop
575
- }
576
- };
577
- if (this.firstRender == false) {
578
- this.app.dispatch({
579
- type: "view_update",
580
- config
581
- });
582
- } else {
583
- this.firstRender = false;
584
- }
585
- }
586
- onpanning(xoff, canvas) {
587
- if (!this.isYblock) canvas.style("left", `${xoff + this.defaultLeft}px`);
588
- else canvas.style("top", `${-xoff + this.defaultTop}px`);
589
- }
590
- async loadBlock(chrObj, canvasHolder, canvas, sheath) {
591
- const runPpArgs = this.setArgs(chrObj);
592
- const runPpMethods = this.isYblock ? this.setMethods(canvasHolder, canvas, sheath) : this.setMethods(canvasHolder, canvas);
593
- const args = Object.assign(runPpArgs, runPpMethods);
594
- await blocklazyload(args).then(async (block) => {
595
- this.block = block;
596
- });
597
- }
598
- };
599
-
600
- // tracks/hic/data/DetailDataFetcher.ts
601
- var DetailDataFetcher = class {
602
- constructor(errList) {
603
- this.obj = {
604
- rglst: []
605
- };
606
- this.errList = errList;
607
- }
608
- isFragData(hic, resolution) {
609
- if (resolution != null) return;
610
- if (!hic.enzyme) {
611
- resolution = hic.bpresolution[hic.bpresolution.length - 1];
612
- return;
613
- }
614
- }
615
- formatFragArgs(enzymefile, chr) {
616
- const arg = {
617
- getdata: 1,
618
- getBED: 1,
619
- file: enzymefile,
620
- rglst: [chr]
621
- };
622
- return arg;
623
- }
624
- /**
625
- * @param arg Formated obj from either fn above
626
- * @param errList
627
- * @returns
628
- */
629
- async getBedData(arg) {
630
- try {
631
- return await dofetch3("tkbedj", { method: "POST", body: JSON.stringify(arg) });
632
- } catch (e) {
633
- this.errList.push(e.message || e);
634
- if (e.stack) console.error(e.stack);
635
- }
636
- }
637
- async getXFragData(hic, resolution, chrx) {
638
- this.isFragData(hic, resolution);
639
- if (!hic.enzymefile) return;
640
- const reqArgs = this.formatFragArgs(hic.enzymefile, chrx);
641
- return await this.getBedData(reqArgs);
642
- }
643
- async getYFragData(hic, chry) {
644
- const reqArgs = this.formatFragArgs(hic.enzymefile, chry);
645
- return await this.getBedData(reqArgs);
646
- }
647
- /**
648
- * Separate request from data fetch
649
- * Returns the additional fragment data
650
- * @param fragCoords
651
- */
652
- async fetchData(hic, detailView, resolution, x, y, fragCoords) {
653
- const fragStrawArgs = {
654
- matrixType: detailView.matrixType,
655
- file: hic.file,
656
- url: hic.url,
657
- pos1: this.determinePosition(hic, x, fragCoords?.x),
658
- pos2: this.determinePosition(hic, y, fragCoords?.y),
659
- nmeth: detailView.nmeth,
660
- resolution
661
- };
662
- if (fragCoords) fragStrawArgs["isfrag"] = true;
663
- try {
664
- const data = dofetch3("hicdata?", {
665
- method: "POST",
666
- body: JSON.stringify(fragStrawArgs)
667
- });
668
- if (data.error) {
669
- this.errList.push(data.error);
670
- }
671
- return data;
672
- } catch (e) {
673
- this.errList.push(e.message || e);
674
- if (e.stack) console.error(e.stack);
675
- }
676
- }
677
- determinePosition(hic, chr, fragCoord) {
678
- if (fragCoord) {
679
- return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${fragCoord.start}:${fragCoord.stop}`;
680
- } else {
681
- return `${hic.nochr ? chr.chr.replace("chr", "") : chr.chr}:${chr.start}:${chr.stop}`;
682
- }
683
- }
684
- };
685
-
686
- // tracks/hic/data/ParseFragData.ts
687
- var ParseFragData = class {
688
- constructor(errLst, items) {
689
- this.id2coord = /* @__PURE__ */ new Map();
690
- this.min = null;
691
- this.max = null;
692
- this.items = [];
693
- this.errLst = errLst;
694
- for (const i of items) {
695
- if (!i.rest || !i.rest[0]) {
696
- this.errLst.push("items[].rest data problem");
697
- }
698
- const id = Number.parseInt(i.rest[0]);
699
- if (Number.isNaN(id)) {
700
- this.errLst.push(`${i.start}.${i.stop} invalid fragment id: ${i.rest[0]}`);
701
- }
702
- this.id2coord.set(id, [i.start, i.stop]);
703
- if (this.min == null) {
704
- this.min = id;
705
- this.max = id;
706
- } else {
707
- this.min = Math.min(this.min, id);
708
- this.max = Math.max(this.max, id);
709
- }
710
- }
711
- }
712
- };
713
-
714
- // tracks/hic/data/DetailDataMapper.ts
715
- var DetailDataMapper = class {
716
- constructor(hic, errList, parent) {
717
- this.frag = {
718
- x: {},
719
- y: {}
720
- };
721
- this.hic = hic;
722
- this.errList = errList;
723
- this.dataFetcher = new DetailDataFetcher(errList);
724
- this.parent = parent;
725
- }
726
- async getFragData(chrx, chry) {
727
- try {
728
- const xFragData = await this.dataFetcher.getXFragData(this.hic, this.parent("calcResolution"), chrx);
729
- if (xFragData) {
730
- if (!xFragData.items) {
731
- this.errList.push(`No fragment data returned for ${chrx.chr}:${chrx.start}-${chrx.stop}`);
732
- return;
733
- }
734
- const xParse = new ParseFragData(this.errList, xFragData.items);
735
- if (this.errList.length) return;
736
- this.frag.x = {
737
- id2coord: xParse.id2coord,
738
- start: xParse.min,
739
- stop: xParse.max
740
- };
741
- const yFragData = await this.dataFetcher.getYFragData(this.hic, chry);
742
- if (this.errList.length) return;
743
- if (yFragData) {
744
- if (!yFragData.items) {
745
- this.errList.push(`No fragment data returned for ${chry.chr}:${chry.start}-${chry.stop}`);
746
- return;
747
- }
748
- const yParse = new ParseFragData(this.errList, yFragData.items);
749
- if (this.errList.length) return;
750
- this.frag.y = {
751
- id2coord: /* @__PURE__ */ new Map(),
752
- start: yParse.min,
753
- stop: yParse.max
754
- };
755
- this.determineMap(yParse.id2coord, chrx, chry);
756
- }
757
- }
758
- } catch (e) {
759
- this.errList.push(e.message || e);
760
- if (e.stack) console.error(e.stack);
761
- }
762
- }
763
- determineMap(map, chrx, chry) {
764
- if (chrx.chr == chry.chr) {
765
- for (const [id, pos] of map) {
766
- this.frag.x["id2coord"].set(id, pos);
767
- }
768
- this.frag.y["id2coord"] = this.frag.x["id2coord"];
769
- } else {
770
- this.frag.y["id2coord"] = map;
771
- }
772
- }
773
- async getData(chrx, chry, fragCoords) {
774
- return await this.dataFetcher.fetchData(
775
- this.hic,
776
- this.parent("state")["detail"],
777
- this.parent("calcResolution"),
778
- chrx,
779
- chry,
780
- fragCoords
781
- );
782
- }
783
- };
784
-
785
- // tracks/hic/data/DetailCoodinates.ts
786
- var DetailCoordinates = class {
787
- constructor(hic, errlist) {
788
- this.hic = hic;
789
- this.errlist = errlist;
790
- }
791
- getCoordinates(chrx, chry, data, resolution, widthHeightPx, fragData) {
792
- const isFirstX = new FirstChrX(this.hic.chrorder, chrx.chr, chry.chr).isFirstX();
793
- const isintrachr = chrx.chr == chry.chr;
794
- const xpxbp = widthHeightPx / (chrx.stop - chrx.start);
795
- const ypxbp = widthHeightPx / (chry.stop - chry.start);
796
- const list = this.calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData);
797
- return list;
798
- }
799
- calculateCoordinates(isFirstX, isintrachr, xpxbp, ypxbp, resolution, chrx, chry, data, fragData) {
800
- const list = [];
801
- for (const [xCoord, yCoord, value] of data.items) {
802
- let coord1, coord2, span1, span2;
803
- if (fragData) {
804
- const idx_start = isFirstX ? xCoord : yCoord;
805
- const idy_start = isFirstX ? yCoord : xCoord;
806
- if (fragData.x.id2coord.has(idx_start)) {
807
- const [a, b] = fragData.x.id2coord.get(idx_start);
808
- coord1 = a;
809
- span1 = b - a;
810
- } else {
811
- this.errlist.push(`[x id error] x: ${idx_start} y: ${idy_start}`);
812
- continue;
813
- }
814
- {
815
- const id_stop = idx_start + resolution;
816
- if (fragData.x.id2coord.has(id_stop)) {
817
- const ab = fragData.x.id2coord.get(id_stop);
818
- span1 = ab[1] - coord1;
819
- }
820
- }
821
- if (fragData.y.id2coord.has(idy_start)) {
822
- const [a, b] = fragData.y.id2coord.get(idy_start);
823
- coord2 = a;
824
- span2 = b - a;
825
- } else {
826
- this.errlist.push(`[y id error] x: ${idx_start} y: ${idy_start}`);
827
- continue;
828
- }
829
- {
830
- const id_stop = idy_start + resolution;
831
- if (fragData.y.id2coord.has(id_stop)) {
832
- const ab = fragData.y.id2coord.get(id_stop);
833
- span2 = ab[1] - coord2;
834
- }
835
- }
836
- } else {
837
- coord1 = isFirstX ? xCoord : yCoord;
838
- coord2 = isFirstX ? yCoord : xCoord;
839
- span1 = resolution;
840
- span2 = resolution;
841
- }
842
- if (isintrachr) {
843
- if (coord1 > chrx.start - span1 && coord1 < chrx.stop && coord2 > chry.start - span2 && coord2 < chry.stop) {
844
- list.push([
845
- Math.floor((coord1 - chrx.start) * xpxbp),
846
- Math.floor((coord2 - chry.start) * ypxbp),
847
- Math.ceil(span1 * xpxbp),
848
- Math.ceil(span2 * ypxbp),
849
- value
850
- ]);
851
- }
852
- if (coord2 > chrx.start - span2 && coord2 < chrx.stop && coord1 > chry.start && coord1 < chry.stop) {
853
- list.push([
854
- Math.floor((coord2 - chrx.start) * xpxbp),
855
- Math.floor((coord1 - chry.start) * ypxbp),
856
- Math.ceil(span2 * xpxbp),
857
- Math.ceil(span1 * ypxbp),
858
- value
859
- ]);
860
- }
861
- continue;
862
- }
863
- list.push([
864
- Math.floor((coord1 - chrx.start) * xpxbp),
865
- Math.floor((coord2 - chry.start) * ypxbp),
866
- Math.ceil(span1 * xpxbp),
867
- Math.ceil(span2 * ypxbp),
868
- value
869
- ]);
870
- }
871
- return list;
872
- }
873
- };
874
-
875
- // tracks/hic/detail/DetailView.ts
876
- var DetailView = class {
877
- constructor(opts) {
878
- this.calcResolution = null;
879
- /** Defaults **/
880
- this.binpx = 2;
881
- this.bbmargin = 1;
882
- this.app = opts.app;
883
- this.hic = opts.hic;
884
- this.plotDiv = opts.plotDiv;
885
- this.sheath = opts.plotDiv.yAxis.append("div").style("position", "relative").style("width", "200px").style("height", "800px");
886
- this.rotor = this.sheath.append("div").style("position", "absolute").style("bottom", "0px").style("transform", "rotate(-90deg)").style("transform-origin", "left bottom");
887
- this.data = opts.data;
888
- this.parent = opts.parent;
889
- this.errList = this.parent("errList");
890
- this.resolution = new Resolution(opts.error);
891
- this.colorizeElement = new ColorizeElement();
892
- this.viewRangeBpW = this.resolution.getDefaultViewSpan(
893
- this.hic,
894
- this.parent("state").x,
895
- this.parent("state").y,
896
- this.parent("state").initialBinNum,
897
- this.parent("state").minBinNum_bp
898
- );
899
- this.dataMapper = new DetailDataMapper(this.hic, opts.error, opts.parent);
900
- this.coordinates = new DetailCoordinates(this.hic, this.errList);
901
- }
902
- renderCanvas(blockwidth) {
903
- this.canvasHolder = this.plotDiv.plot.append("div").style("position", "relative").style("width", `${this.xBlock.bbw}px`).style("height", `${this.yBlock.bbw}px`).style("overflow", "hidden");
904
- this.canvas = this.canvasHolder.append("canvas").style("display", "block").style("position", "absolute").attr("data-testid", "sjpp-hic-detail-canvas").attr("width", blockwidth).attr("height", blockwidth).on("mousedown", (event) => {
905
- const body = select_default(document.body);
906
- const x = event.clientX;
907
- const y = event.clientY;
908
- const oldx = Number.parseInt(this.canvas.style("left"));
909
- const oldy = Number.parseInt(this.canvas.style("top"));
910
- body.on("mousemove", (event2) => {
911
- const xoff = event2.clientX - x;
912
- const yoff = event2.clientY - y;
913
- this.xBlock.block.panning(xoff);
914
- this.yBlock.block.panning(yoff);
915
- this.canvas.style("left", `${oldx + xoff}px`).style("top", `${oldy + yoff}px`);
916
- });
917
- body.on("mouseup", (event2) => {
918
- body.on("mousemove", null).on("mouseup", null);
919
- const xoff = event2.clientX - x;
920
- const yoff = event2.clientY - y;
921
- this.xBlock.block.pannedby(xoff);
922
- this.yBlock.block.pannedby(yoff);
923
- });
924
- });
925
- }
926
- async render() {
927
- this.calcResolution = this.parent("calcResolution");
928
- const state = this.parent("state");
929
- this.xBlock = new DetailBlock(
930
- this.app,
931
- this.hic,
932
- state.settings.widthHeightPx,
933
- this.bbmargin,
934
- this.plotDiv.xAxis,
935
- false
936
- );
937
- this.yBlock = new DetailBlock(this.app, this.hic, state.settings.widthHeightPx, this.bbmargin, this.rotor, true);
938
- this.renderCanvas(state.settings.widthHeightPx);
939
- await this.xBlock.loadBlock(state.x, this.canvasHolder, this.canvas);
940
- await this.yBlock.loadBlock(state.y, this.canvasHolder, this.canvas, this.sheath);
941
- this.update(this.data);
942
- }
943
- async update(data) {
944
- if (data.items.length == 0) {
945
- this.app.dispatch({ type: "loading_active", active: false });
946
- return;
947
- }
948
- this.data = data;
949
- const state = this.parent("state");
950
- const initialWidth = Number.parseInt(this.canvas.attr("width"));
951
- const holderChange = Number.parseInt(this.canvasHolder.style("width")) - initialWidth + state.settings.widthHeightPx;
952
- this.canvasHolder.style("width", `${holderChange}px`).style("height", `${holderChange}px`);
953
- this.canvas.attr("width", `${state.settings.widthHeightPx}px`).attr("height", `${state.settings.widthHeightPx}px`);
954
- if (this.xBlock.block.width != state.settings.widthHeightPx) {
955
- this.xBlock.block.width = state.settings.widthHeightPx;
956
- this.yBlock.block.width = state.settings.widthHeightPx;
957
- this.xBlock.block.zoom2px(0, initialWidth);
958
- this.yBlock.block.zoom2px(0, initialWidth);
959
- }
960
- this.ctx = this.canvas.node().getContext("2d");
961
- const coords = this.coordinates.getCoordinates(
962
- state.x,
963
- state.y,
964
- this.parent("data"),
965
- this.parent("calcResolution"),
966
- state.settings.widthHeightPx,
967
- this.parent("fragData")
968
- );
969
- this.coords = coords;
970
- this.ctx.clearRect(0, 0, state.settings.widthHeightPx, state.settings.widthHeightPx);
971
- for (const [xCoord, yCoord, width, height, value] of this.coords) {
972
- this.colorizeElement.colorizeElement(
973
- xCoord,
974
- yCoord,
975
- value,
976
- this.ctx,
977
- width,
978
- height,
979
- this.parent("min"),
980
- this.parent("max"),
981
- "detail"
982
- );
983
- }
984
- this.app.dispatch({ type: "loading_active", active: false });
985
- }
986
- };
987
-
988
- // tracks/hic/axes/Chromosome.ts
989
- var Chromosome = class {
990
- constructor(chr, width) {
991
- this.label = chr;
992
- this.width = width;
993
- }
994
- };
995
-
996
- // tracks/hic/grid/Grid.ts
997
- var Grid = class _Grid {
998
- constructor(chrlst, resolution, chrlookup, binpx) {
999
- this.chromosomeMatrix = /* @__PURE__ */ new Map();
1000
- this.chromosomeList = [];
1001
- this.xoff = 0;
1002
- this.yoff = 0;
1003
- this.chr2px = [];
1004
- this.chrlst = chrlst;
1005
- let totalpx = this.chrlst.length;
1006
- for (const chr of this.chrlst) {
1007
- const w = Math.ceil(chrlookup[chr.toUpperCase()].len / resolution) * binpx;
1008
- const chromosome = new Chromosome(chr, w);
1009
- this.chromosomeList.push(chromosome);
1010
- this.chr2px[chr] = w;
1011
- totalpx += w;
1012
- }
1013
- this.totalpx = totalpx;
1014
- for (let i = 0; i < this.chrlst.length; i++) {
1015
- const chrx = this.chrlst[i];
1016
- this.chromosomeMatrix.set(chrx, /* @__PURE__ */ new Map());
1017
- let yoff = 0;
1018
- for (let j = 0; j <= i; j++) {
1019
- const chry = this.chrlst[j];
1020
- const chrxChrLen = chrlookup[chrx.toUpperCase()].len;
1021
- const chryChrLen = chrlookup[chry.toUpperCase()].len;
1022
- const xbins = Math.ceil(chrxChrLen / resolution) * binpx;
1023
- const ybins = Math.ceil(chryChrLen / resolution) * binpx;
1024
- this.chromosomeMatrix.get(chrx).set(chry, {
1025
- x: this.xoff,
1026
- y: yoff,
1027
- xbins,
1028
- ybins,
1029
- data: []
1030
- //Empty array of data to fill later
1031
- });
1032
- yoff += this.chr2px[chry] + _Grid.borderWidth;
1033
- }
1034
- this.yoff = yoff;
1035
- this.xoff += this.chr2px[chrx] + _Grid.borderWidth;
1036
- }
1037
- }
1038
- static {
1039
- this.checkerFill = "#DEF3FA";
1040
- }
1041
- static {
1042
- this.spaceColor = "#CCC";
1043
- }
1044
- static {
1045
- this.fontSize = 15;
1046
- }
1047
- static {
1048
- this.font = font;
1049
- }
1050
- static {
1051
- this.borderWidth = 1;
1052
- }
1053
- static {
1054
- this.defaultChrLabWidth = 100;
1055
- }
1056
- };
1057
-
1058
- // tracks/hic/viewmodel/GridViewModel.ts
1059
- var GridViewModel = class {
1060
- constructor(opts) {
1061
- this.grid = new Grid(opts.hic.chrlst, opts.resolution || opts.hic.bpresolution[0], opts.hic.genome.chrlookup, 1);
1062
- }
1063
- };
1064
-
1065
- // tracks/hic/grid/GridRenderer.ts
1066
- var GridRenderer = class {
1067
- constructor(svg, layerMap, layerSv, grid) {
1068
- this.svg = svg;
1069
- this.layerMap = layerMap.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
1070
- this.layerSv = layerSv.attr("transform", `translate(${Grid.defaultChrLabWidth}, ${Grid.fontSize})`);
1071
- this.grid = grid;
1072
- }
1073
- render() {
1074
- this.renderAxisX(this.grid);
1075
- this.renderAxisY(this.grid);
1076
- this.svg.attr("width", Grid.defaultChrLabWidth + this.grid.xoff).attr("height", Grid.fontSize + this.grid.yoff);
1077
- }
1078
- renderAxisX(grid) {
1079
- let xoff = 0;
1080
- this.grid.chromosomeList.forEach((chr, index) => {
1081
- const chrw = chr.width;
1082
- if (index % 2 === 0) {
1083
- this.layerMap.append("rect").attr("x", xoff).attr("width", chrw).attr("height", Grid.fontSize).attr("y", -Grid.fontSize).attr("fill", Grid.checkerFill);
1084
- }
1085
- this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-xAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "middle").attr("font-size", 12).attr("x", xoff + chrw / 2).text(chr.label);
1086
- xoff += chrw;
1087
- this.layerSv.append("line").attr("x1", xoff).attr("x2", xoff).attr("y2", grid.totalpx).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
1088
- xoff += Grid.borderWidth;
1089
- });
1090
- }
1091
- renderAxisY(grid) {
1092
- let yoff = 0;
1093
- this.grid.chromosomeList.forEach((chr, index) => {
1094
- const chrh = chr.width;
1095
- if (index % 2 === 0) {
1096
- this.layerMap.append("rect").attr("x", -Grid.defaultChrLabWidth).attr("width", Grid.defaultChrLabWidth).attr("height", chrh).attr("y", yoff).attr("fill", Grid.checkerFill);
1097
- }
1098
- this.layerMap.append("text").attr("data-testid", `sjpp-hic-chr-yAxis-label`).attr("font-family", Grid.font).attr("text-anchor", "end").attr("dominant-baseline", "central").attr("font-size", 12).attr("y", yoff + chrh / 2).text(chr.label);
1099
- yoff += chrh;
1100
- this.layerSv.append("line").attr("x2", grid.totalpx).attr("y1", yoff).attr("y2", yoff).attr("stroke", Grid.spaceColor).attr("shape-rendering", "crispEdges");
1101
- yoff += Grid.borderWidth;
1102
- });
1103
- }
1104
- };
1105
-
1106
- // tracks/hic/genome/ChrsTooltips.ts
1107
- var ChrsTooltips = class {
1108
- constructor() {
1109
- this.chrx_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1110
- this.chry_tip = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1111
- }
1112
- render(img, chrx, chry) {
1113
- const p = img.node().getBoundingClientRect();
1114
- this.chrx_tip.clear().show(p.left, p.top).d.style("top", null).attr("data-testid", "sjpp-hic-chrx-tooltip").style("bottom", window.innerHeight - p.top - window.pageYOffset + "px").text(chrx);
1115
- this.chry_tip.clear().show(p.left, p.top).d.style("left", null).attr("data-testid", "sjpp-hic-chry-tooltip").style("right", document.body.clientWidth - p.left - window.pageXOffset + "px").text(chry);
1116
- }
1117
- };
1118
-
1119
- // tracks/hic/grid/GridElementRenderer.ts
1120
- var GridElementRenderer = class {
1121
- constructor(layerMap, app) {
1122
- this.app = app;
1123
- this.layerMap = layerMap;
1124
- this.tooltips = new ChrsTooltips();
1125
- }
1126
- render(obj, lead, follow, holder) {
1127
- obj.canvas = holder.append("canvas").style("display", "none").node();
1128
- obj.ctx = obj.canvas.getContext("2d");
1129
- obj.canvas.width = obj.xbins;
1130
- obj.canvas.height = obj.ybins;
1131
- obj.img = this.layerMap.append("image").attr("width", obj.canvas.width).attr("height", obj.canvas.height).attr("x", obj.x).attr("y", obj.y).on("click", async () => {
1132
- await this.app.dispatch({
1133
- type: "view_create",
1134
- view: "chrpair",
1135
- config: {
1136
- x: {
1137
- chr: lead
1138
- },
1139
- y: {
1140
- chr: follow
1141
- }
1142
- }
1143
- });
1144
- }).on("mouseover", () => {
1145
- this.tooltips.render(obj.img, lead, follow);
1146
- });
1147
- if (lead != follow) {
1148
- obj.canvas2 = holder.append("canvas").style("display", "none").node();
1149
- obj.canvas2.width = obj.ybins;
1150
- obj.canvas2.height = obj.xbins;
1151
- obj.ctx2 = obj.canvas2.getContext("2d");
1152
- obj.img2 = this.layerMap.append("image").attr("width", obj.canvas2.width).attr("height", obj.canvas2.height).attr("x", obj.y).attr("y", obj.x).on("click", async () => {
1153
- await this.app.dispatch({
1154
- type: "view_create",
1155
- view: "chrpair",
1156
- config: {
1157
- x: {
1158
- chr: follow
1159
- },
1160
- y: {
1161
- chr: lead
1162
- }
1163
- }
1164
- });
1165
- }).on("mouseover", () => {
1166
- this.tooltips.render(obj.img2, follow, lead);
1167
- });
1168
- } else {
1169
- obj.ctx2 = obj.ctx;
1170
- }
1171
- }
1172
- };
1173
-
1174
- // tracks/hic/grid/GridElementsRenderer.ts
1175
- var GridElementsRenderer = class {
1176
- constructor(grid, layerMap, app) {
1177
- this.grid = grid;
1178
- this.gridElementRenderer = new GridElementRenderer(layerMap, app);
1179
- }
1180
- render(holder) {
1181
- for (const [chrx, chryMap] of this.grid.chromosomeMatrix) {
1182
- for (const [chry, gridElem] of chryMap) {
1183
- this.gridElementRenderer.render(gridElem, chrx, chry, holder);
1184
- }
1185
- }
1186
- }
1187
- };
1188
-
1189
- // tracks/hic/genome/GenomeView.ts
1190
- var GenomeView = class {
1191
- constructor(opts) {
1192
- /** Dom */
1193
- this.tip = new Menu();
1194
- this.pica_x = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1195
- this.pica_y = new Menu({ border: "solid 1px #ccc", padding: "0px", offsetX: 0, offsetY: 0 });
1196
- /** Data */
1197
- /** px width for each chr */
1198
- this.chr2px = {};
1199
- this.lead2follow = /* @__PURE__ */ new Map();
1200
- this.values = [];
1201
- /** Defaults */
1202
- this.defaultChrLabWidth = 100;
1203
- this.borderwidth = 1;
1204
- this.default_maxVPerc = 5;
1205
- this.fontsize = 15;
1206
- this.xoff = 0;
1207
- this.yoff = 0;
1208
- this.binpx = 1;
1209
- this.atdev_chrnum = 8;
1210
- this.min = 0;
1211
- this.max = 0;
1212
- this.app = opts.app;
1213
- this.hic = opts.hic;
1214
- this.plotDiv = opts.plotDiv;
1215
- this.data = opts.data;
1216
- this.parent = opts.parent;
1217
- this.resolution = opts.resolution || opts.hic.bpresolution[0];
1218
- this.svg = this.plotDiv.plot.append("svg").attr("data-testid", "sjpp-hic-genome-svg");
1219
- this.layer_map = this.svg.append("g").attr("data-testid", "sjpp-hic-layerMap-g");
1220
- this.layer_sv = this.svg.append("g").attr("data-testid", "sjpp-hic-layerSv-g");
1221
- this.colorizeElement = new ColorizeElement();
1222
- this.viewModel = new GridViewModel(opts);
1223
- this.viewRender = new GridRenderer(this.svg, this.layer_map, this.layer_sv, this.viewModel.grid);
1224
- this.gridElementsRenderer = new GridElementsRenderer(this.viewModel.grid, this.layer_map, this.app);
1225
- this.gridFormattedData = new GridElementsFormattedData();
1226
- }
1227
- makeSv() {
1228
- const unknownchr = /* @__PURE__ */ new Set();
1229
- const radius = 8;
1230
- for (const item of this.hic.sv.items) {
1231
- const _o = this.lead2follow.get(item.chr1);
1232
- if (!_o) {
1233
- unknownchr.add(item.chr1);
1234
- continue;
1235
- }
1236
- const obj = _o.get(item.chr2);
1237
- if (!obj) {
1238
- unknownchr.add(item.chr2);
1239
- continue;
1240
- }
1241
- const p1 = item.position1 / this.resolution;
1242
- const p2 = item.position2 / this.resolution;
1243
- this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cx", obj.x + p1).attr("cy", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
1244
- this.tooltipSv(event, item);
1245
- }).on("mouseout", () => {
1246
- this.tip.hide();
1247
- }).on("click", () => {
1248
- this.clickSv(item);
1249
- });
1250
- if (obj.img2) {
1251
- this.layer_sv.append("circle").attr("data-testid", "sjpp-hic-genome-view-sv-circle-2").attr("stroke", "black").attr("fill", "white").attr("fill-opacity", 0).attr("cy", obj.x + p1).attr("cx", obj.y + p2).attr("r", radius).on("mouseover", (event) => {
1252
- this.tooltipSv(event, item);
1253
- }).on("mouseout", () => {
1254
- this.tip.hide();
1255
- }).on("click", () => {
1256
- this.clickSv(item);
1257
- });
1258
- }
1259
- }
1260
- }
1261
- tooltipSv(event, item) {
1262
- this.tip.clear().show(event.clientX, event.clientY).d.append("div").text(
1263
- item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`
1264
- );
1265
- }
1266
- clickSv(item) {
1267
- const default_svpointspan = 5e5;
1268
- const default_subpanelpxwidth = 600;
1269
- const subpanel_bordercolor = "rgba(200,0,0,.1)";
1270
- const pane = newpane({ x: 100, y: 100 });
1271
- pane.header.text(
1272
- this.hic.name + " " + (item.chr1 == item.chr2 ? `${item.chr1}:${item.position1}-${item.position2}` : `${item.chr1}:${item.position1}>${item.chr2}:${item.position2}`)
1273
- );
1274
- const tracks = [
1275
- {
1276
- type: tkt.hicstraw,
1277
- file: this.hic.file,
1278
- enzyme: this.hic.enzyme,
1279
- maxpercentage: this.default_maxVPerc,
1280
- pyramidup: 1,
1281
- name: this.hic.name
1282
- }
1283
- ];
1284
- if (this.hic.tklst) {
1285
- for (const t of this.hic.tklst) {
1286
- tracks.push(t);
1287
- }
1288
- }
1289
- first_genetrack_tolist(this.hic.genome, tracks);
1290
- const arg = {
1291
- holder: pane.body,
1292
- hostURL: this.hic.hostURL,
1293
- jwt: this.hic.jwt,
1294
- genome: this.hic.genome,
1295
- nobox: 1,
1296
- tklst: tracks
1297
- };
1298
- if (item.chr1 == item.chr2 && Math.abs(item.position2 - item.position1) < default_svpointspan * 2) {
1299
- arg.chr = item.chr1;
1300
- const w = Math.abs(item.position2 - item.position1);
1301
- arg.start = Math.max(1, Math.min(item.position1, item.position2) - w);
1302
- arg.stop = Math.min(
1303
- this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
1304
- Math.max(item.position1, item.position2) + w
1305
- );
1306
- } else {
1307
- arg.chr = item.chr1;
1308
- arg.start = Math.max(1, item.position1 - default_svpointspan / 2);
1309
- arg.stop = Math.min(
1310
- this.hic.genome.chrlookup[item.chr1.toUpperCase()].len,
1311
- item.position1 + default_svpointspan / 2
1312
- );
1313
- arg.width = default_subpanelpxwidth;
1314
- arg.subpanels = [
1315
- {
1316
- chr: item.chr2,
1317
- start: Math.max(1, item.position2 - default_svpointspan / 2),
1318
- stop: Math.min(
1319
- this.hic.genome.chrlookup[item.chr2.toUpperCase()].len,
1320
- item.position2 + default_svpointspan / 2
1321
- ),
1322
- width: default_subpanelpxwidth,
1323
- leftpad: 10,
1324
- leftborder: subpanel_bordercolor
1325
- }
1326
- ];
1327
- }
1328
- blocklazyload(arg);
1329
- }
1330
- render() {
1331
- this.viewRender.render();
1332
- this.gridElementsRenderer.render(this.hic.holder);
1333
- if (this.hic.sv && this.hic.sv.items) {
1334
- this.makeSv();
1335
- }
1336
- this.update(this.data);
1337
- }
1338
- update(data) {
1339
- this.data = data;
1340
- this.min = this.parent("min");
1341
- this.max = this.parent("max");
1342
- for (const data2 of this.data) {
1343
- if (!this.hic.chrlst.includes(data2.lead) || !this.hic.chrlst.includes(data2.follow)) continue;
1344
- const obj = this.viewModel.grid.chromosomeMatrix.get(data2.lead).get(data2.follow);
1345
- if (!obj) continue;
1346
- obj.ctx.clearRect(0, 0, obj.canvas.width, obj.canvas.height);
1347
- if (obj.canvas2) {
1348
- obj.ctx2.clearRect(0, 0, obj.canvas2.width, obj.canvas.height);
1349
- }
1350
- obj.data = this.gridFormattedData.formatData("genome", data2.items, this.binpx, this.resolution);
1351
- for (const [xPx, yPx, value] of obj.data) {
1352
- this.colorizeElement.colorizeElement(xPx, yPx, value, obj, this.binpx, this.binpx, this.min, this.max, "genome");
1353
- }
1354
- obj.img.attr("xlink:href", obj.canvas.toDataURL());
1355
- if (obj.canvas2) {
1356
- obj.img2.attr("xlink:href", obj.canvas2.toDataURL());
1357
- }
1358
- }
1359
- this.app.dispatch({ type: "loading_active", active: false });
1360
- }
1361
- };
1362
-
1363
- // tracks/hic/controls/NormalizationMethodControl.ts
1364
- var NormalizationMethodControl = class {
1365
- constructor(holder, normalization, defaultNmeth, callback) {
1366
- this.holder = holder;
1367
- this.normalization = normalization;
1368
- this.defaultNmeth = defaultNmeth;
1369
- this.callback = callback;
1370
- }
1371
- render() {
1372
- if (!this.normalization?.length) {
1373
- this.nmethSelect = this.holder.text(this.defaultNmeth);
1374
- } else {
1375
- this.nmethSelect = this.holder.attr("data-testid", "sjpp-hic-nmeth-select").style("margin-right", "10px").append("select").on("change", async () => {
1376
- const nmeth = this.nmethSelect.node().value;
1377
- this.callback(nmeth, "nmeth");
1378
- });
1379
- for (const n of this.normalization) {
1380
- this.nmethSelect.append("option").text(n);
1381
- }
1382
- }
1383
- }
1384
- update(option) {
1385
- const options = this.nmethSelect.node().options;
1386
- if (!options) return;
1387
- const selectedNmeth = Array.from(options).find((o) => o.value === option);
1388
- if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
1389
- selectedNmeth.selected = true;
1390
- }
1391
- };
1392
-
1393
- // tracks/hic/controls/CutoffControl.ts
1394
- var CutoffControl = class {
1395
- constructor(holder, value, callback) {
1396
- this.holder = holder;
1397
- this.value = value;
1398
- this.callback = callback;
1399
- }
1400
- render(opts) {
1401
- const cutoffDiv = this.holder.attr("data-testid", "sjpp-hic-cutoff-control").style("margin-right", "10px").append("input").attr("type", "number").style("width", opts && "width" in opts ? opts.width : "80px").style("margin-left", "0px").attr("type", "number").property("value", this.value).on("keyup", async (event) => {
1402
- if (event.code != "Enter") return;
1403
- const v = event.target.value;
1404
- this.callback(v);
1405
- });
1406
- return cutoffDiv;
1407
- }
1408
- };
1409
-
1410
- // tracks/hic/controls/MatrixTypeControl.ts
1411
- var MatrixTypeControl = class {
1412
- constructor(holder, callback) {
1413
- this.values = [
1414
- { label: "Observed", value: "observed" },
1415
- { label: "Expected", value: "expected" },
1416
- { label: "Observed/Expected", value: "oe" },
1417
- { label: "Log(Observed/Expected)", value: "log(oe)" }
1418
- // TODO: add server side logic to support these options
1419
- // { label: 'Log(Observed + 1)', value: 'log(obs+1)'},
1420
- // { label: 'Observed Pearson', value: 'op'}
1421
- ];
1422
- this.holder = holder;
1423
- this.callback = callback;
1424
- }
1425
- render() {
1426
- this.matrixSelect = this.holder.attr("data-testid", "sjpp-hic-matrix-type-select").style("margin-right", "10px").append("select").on("change", async () => {
1427
- this.callback(this.matrixSelect.node().value, "matrixType");
1428
- });
1429
- for (const matrixType of this.values) {
1430
- this.matrixSelect.append("option").text(matrixType.label).attr("value", matrixType.value);
1431
- }
1432
- }
1433
- update(option) {
1434
- const options = this.matrixSelect.node().options;
1435
- if (!options) return;
1436
- const selectedNmeth = Array.from(options).find((o) => o.value === option);
1437
- if (!selectedNmeth) throw `Invalid normalization method: ${option}`;
1438
- selectedNmeth.selected = true;
1439
- }
1440
- };
1441
-
1442
- // tracks/hic/controls/ControlPanel.ts
1443
- var ControlPanel = class _ControlPanel {
1444
- constructor(opts) {
1445
- this.zoomBlockCallback = (bool) => {
1446
- const detailView = this.parent("detail");
1447
- detailView.xBlock.block.zoomblock(2, bool);
1448
- detailView.yBlock.block.zoomblock(2, bool);
1449
- };
1450
- this.minCallback = (v) => {
1451
- if (Number(v) > Number(this.parent("max"))) {
1452
- this.error("Min cutoff cannot be greater than max cutoff");
1453
- } else {
1454
- this.parent("min", Number(v));
1455
- this.reColorHeatmap();
1456
- this.parent("infoBar").update();
1457
- }
1458
- };
1459
- this.maxCallback = (v) => {
1460
- if (Number(v) < Number(this.parent("min"))) {
1461
- this.error(`Max cutoff cannot be less than min cutoff`);
1462
- } else if (Number(v) < 0) {
1463
- this.error(`Max cutoff cannot be less than 0`);
1464
- } else {
1465
- this.parent("max", Number(v));
1466
- this.reColorHeatmap();
1467
- this.parent("infoBar").update();
1468
- }
1469
- };
1470
- this.reColorHeatmap = () => {
1471
- if (this.parent("activeView") == "genome") {
1472
- const genomeView = this.parent("genome");
1473
- const chrMatrix = genomeView.viewRender.grid.chromosomeMatrix;
1474
- if (!chrMatrix) return;
1475
- for (const map of chrMatrix) {
1476
- const yMap = map[1];
1477
- for (const obj of yMap) {
1478
- const canvasObj = obj[1];
1479
- if (!canvasObj) continue;
1480
- for (const [leadpx, followpx, val] of canvasObj.data) {
1481
- this.colorizeElement.colorizeElement(
1482
- leadpx,
1483
- followpx,
1484
- val,
1485
- canvasObj,
1486
- 1,
1487
- 1,
1488
- this.parent("min"),
1489
- this.parent("max"),
1490
- "genome"
1491
- );
1492
- }
1493
- canvasObj.img.attr("xlink:href", canvasObj.canvas.toDataURL());
1494
- if (canvasObj.canvas2) {
1495
- canvasObj.img2.attr("xlink:href", canvasObj.canvas2.toDataURL());
1496
- }
1497
- }
1498
- }
1499
- } else if (this.parent("activeView") == "chrpair") {
1500
- const view = this.parent("chrpair");
1501
- for (const [xCoord, yCoord, val] of view.data) {
1502
- this.colorizeElement.colorizeElement(
1503
- xCoord,
1504
- yCoord,
1505
- val,
1506
- view.ctx,
1507
- view.binpx,
1508
- view.binpx,
1509
- this.parent("min"),
1510
- this.parent("max"),
1511
- "chrpair"
1512
- );
1513
- }
1514
- } else if (this.parent("activeView") == "detail") {
1515
- const view = this.parent("detail");
1516
- for (const [xCoord, yCoord, width, height, value] of view.coords) {
1517
- this.colorizeElement.colorizeElement(
1518
- xCoord,
1519
- yCoord,
1520
- value,
1521
- view.ctx,
1522
- width,
1523
- height,
1524
- this.parent("min"),
1525
- this.parent("max"),
1526
- "detail"
1527
- );
1528
- }
1529
- }
1530
- };
1531
- this.dropdownCallback = (v, prop) => {
1532
- const state = this.app.getState();
1533
- this.app.dispatch({
1534
- type: "view_update",
1535
- view: state.currView,
1536
- config: { [prop]: v }
1537
- });
1538
- };
1539
- this.type = _ControlPanel.type;
1540
- this.controls = {};
1541
- this.app = opts.app;
1542
- this.controlsDiv = opts.controlsDiv;
1543
- this.hic = opts.hic;
1544
- this.colorizeElement = new ColorizeElement();
1545
- this.parent = opts.parent;
1546
- this.error = opts.error;
1547
- }
1548
- static {
1549
- this.type = "controlPanel";
1550
- }
1551
- getState(appState) {
1552
- return appState;
1553
- }
1554
- addLabel(tr, text) {
1555
- return tr.append("td").style("color", "#858585").style("font-size", ".8em").style("vertical-align", text.toUpperCase() == "VIEW" ? "top" : "middle").text(text.toUpperCase());
1556
- }
1557
- init() {
1558
- const state = this.app.getState();
1559
- const menuWrapper = this.controlsDiv.attr("data-testid", "sjpp-hic-control-panel").style("background", "rgb(253, 250, 244)").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc");
1560
- let menuVisible = true;
1561
- this.controlsDiv.append("button").attr("data-testid", "sjpp-hic-burger-btn").style("display", "block").style("border", "none").style("font-size", "1.5em").style("background", "none").html("&#8801;").on("click", () => {
1562
- menuVisible = !menuVisible;
1563
- menu.style("display", menuVisible ? "block" : "none");
1564
- });
1565
- const menu = menuWrapper.append("div").attr("class", "sjpp-hic-menu").attr("data-testid", "sjpp-hic-menu").style("display", menuVisible ? "block" : "none");
1566
- const menuTable = menu.append("table").style("border-spacing", "3px");
1567
- this.controls.normalizationRow = menuTable.append("tr");
1568
- this.addLabel(this.controls.normalizationRow, "NORMALIZATION");
1569
- this.controls.nmeth = new NormalizationMethodControl(
1570
- this.controls.normalizationRow.append("td").attr("class", "sjpp-nmeth-select"),
1571
- this.hic.normalization,
1572
- state.defaultNmeth,
1573
- this.dropdownCallback
1574
- );
1575
- this.controls.nmeth.render();
1576
- this.controls.minCutoffRow = menuTable.append("tr");
1577
- this.controls.minCutoffLabel = this.addLabel(this.controls.minCutoffRow, "");
1578
- this.controls.inputBpMinV = new CutoffControl(
1579
- this.controls.minCutoffRow.append("td"),
1580
- this.parent("min"),
1581
- this.minCallback
1582
- ).render({ width: "120px" });
1583
- this.controls.maxCutoffRow = menuTable.append("tr");
1584
- this.controls.maxCutoffLabel = this.addLabel(this.controls.maxCutoffRow, "");
1585
- this.controls.inputBpMaxV = new CutoffControl(
1586
- this.controls.maxCutoffRow.append("td"),
1587
- this.parent("max"),
1588
- this.maxCallback
1589
- ).render({ width: "120px" });
1590
- this.controls.matrixTypeRow = menuTable.append("tr");
1591
- this.addLabel(this.controls.matrixTypeRow, "matrix type");
1592
- this.controls.matrixType = new MatrixTypeControl(this.controls.matrixTypeRow.append("td"), this.dropdownCallback);
1593
- this.controls.matrixType.render();
1594
- this.controls.widthRow = menuTable.append("tr");
1595
- this.addLabel(this.controls.widthRow, "WIDTH / height");
1596
- this.controls.width = this.controls.widthRow.append("td");
1597
- this.controls.width.attr("data-testid", "sjpp-hic-block-size-input").style("margin-right", "10px").append("input").attr("type", "number").style("width", "80px").style("margin-left", "0px").attr("type", "number").property("value", state.width).on("keyup", async (event) => {
1598
- if (event.code != "Enter") return;
1599
- const v = event.target.value;
1600
- this.app.dispatch({
1601
- type: "view_update",
1602
- config: {
1603
- settings: { widthHeightPx: Number.parseInt(v) }
1604
- }
1605
- });
1606
- });
1607
- const viewRow = menuTable.append("tr");
1608
- this.addLabel(viewRow, "VIEW");
1609
- const viewBtnDiv = viewRow.append("td");
1610
- this.controls.view = viewBtnDiv.append("span").attr("data-testid", "sjpp-hic-view-span").style("padding-right", "5px").style("display", "block");
1611
- this.controls.genomeViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-genome-view-btn").style("display", "none").style("padding", "2px").style("margin-top", "4px").html("&#8810; Genome").on("click", async () => {
1612
- await this.app.dispatch({
1613
- type: "view_create",
1614
- view: "genome",
1615
- config: {
1616
- x: {},
1617
- y: {}
1618
- }
1619
- });
1620
- });
1621
- this.controls.chrpairViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-chrpair-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").on("click", async () => {
1622
- const currState = this.app.getState();
1623
- await this.app.dispatch({
1624
- type: "view_create",
1625
- view: "chrpair",
1626
- config: {
1627
- x: {
1628
- chr: currState.x.chr
1629
- },
1630
- y: {
1631
- chr: currState.y.chr
1632
- }
1633
- }
1634
- });
1635
- });
1636
- this.controls.horizontalViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-horizontal-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("Horizontal View &#8811;").on("click", async () => {
1637
- await this.app.dispatch({
1638
- type: "view_create",
1639
- view: "horizontal"
1640
- });
1641
- });
1642
- this.controls.detailViewBtn = viewBtnDiv.append("button").attr("data-testid", "sjpp-hic-detail-view-btn").style("display", "none").style("padding", "2px").style("margin", "4px 0px").html("&#8810; Detailed View").on("click", async () => {
1643
- await this.app.dispatch({
1644
- type: "view_create",
1645
- view: "detail"
1646
- });
1647
- });
1648
- this.controls.zoomDiv = menuTable.append("tr").attr("data-testid", "sjpp-hic-zoom-div").style("display", state.currView == "detail" ? "contents" : "none");
1649
- this.addLabel(this.controls.zoomDiv, "ZOOM");
1650
- const zoomDiv = this.controls.zoomDiv.append("td");
1651
- this.controls.zoomIn = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-in-btn").style("margin-right", "10px").text("In").on("click", () => {
1652
- this.zoomBlockCallback(false);
1653
- });
1654
- this.controls.zoomOut = zoomDiv.append("button").attr("data-testid", "sjpp-hic-zoom-out-btn").style("margin-right", "10px").text("Out").on("click", () => {
1655
- this.zoomBlockCallback(true);
1656
- });
1657
- }
1658
- showBtns() {
1659
- const state = this.app.getState();
1660
- this.controls.genomeViewBtn.style("display", state.currView === "genome" ? "none" : "inline-block");
1661
- if (state.currView === "detail") {
1662
- this.controls.chrpairViewBtn.html(`&#8810; Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
1663
- this.controls.horizontalViewBtn.style("display", "block");
1664
- this.controls.zoomDiv.style("display", "contents");
1665
- this.controls.detailViewBtn.style("display", "none");
1666
- } else if (state.currView === "horizontal") {
1667
- this.controls.chrpairViewBtn.html(`&#8810; Entire ${state.x.chr}-${state.y.chr}`).style("display", "block");
1668
- this.controls.detailViewBtn.style("display", "block");
1669
- this.controls.horizontalViewBtn.style("display", "none");
1670
- this.controls.zoomDiv.style("display", "none");
1671
- } else {
1672
- this.controls.chrpairViewBtn.style("display", "none");
1673
- this.controls.horizontalViewBtn.style("display", "none");
1674
- this.controls.detailViewBtn.style("display", "none");
1675
- this.controls.zoomDiv.style("display", "none");
1676
- this.controls.widthRow.style("display", "none");
1677
- }
1678
- }
1679
- showHideControls() {
1680
- const state = this.app.getState();
1681
- this.controls.normalizationRow.style("display", state.currView == "horizontal" ? "none" : "");
1682
- this.controls.minCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
1683
- this.controls.maxCutoffRow.style("display", state.currView == "horizontal" ? "none" : "");
1684
- this.controls.matrixTypeRow.style("display", state.currView == "horizontal" ? "none" : "");
1685
- this.controls.widthRow.style("display", state.currView == "detail" ? "contents" : "none");
1686
- }
1687
- main(appState) {
1688
- const state = this.app.getState(appState);
1689
- this.controls.nmeth.update(state[state.currView].nmeth);
1690
- this.controls.matrixType.update(state[state.currView].matrixType);
1691
- this.controls.zoomDiv.style("display", state.currView == "detail" ? "contents" : "none");
1692
- if (state.currView == "chrpair") {
1693
- this.controls.view.text(`${state.x.chr}-${state.y.chr} Pair`);
1694
- } else {
1695
- this.controls.view.text(state.currView.charAt(0).toUpperCase() + state.currView.slice(1));
1696
- }
1697
- const formatAbsMin = this.parent("absMin") < 1e-5 ? Number(this.parent("absMin")).toExponential(1) : Number(this.parent("absMin").toFixed(6));
1698
- const formatAbsMax = this.parent("absMax") < 1e-5 ? Number(this.parent("absMax")).toExponential(1) : Number(this.parent("absMax").toFixed(6));
1699
- this.controls.width.select("input").property("value", state.settings.widthHeightPx);
1700
- this.controls.inputBpMinV.property("value", this.parent("min"));
1701
- this.controls.inputBpMaxV.property("value", this.parent("max"));
1702
- this.controls.minCutoffLabel.html(`MIN CUTOFF <br>(>= ${formatAbsMin})`);
1703
- this.controls.maxCutoffLabel.html(`MAX CUTOFF <br>(<= ${formatAbsMax})`);
1704
- this.showBtns();
1705
- this.showHideControls();
1706
- }
1707
- };
1708
- var controlPanelInit = getCompInit(ControlPanel);
1709
-
1710
- // tracks/hic/dom/InfoBar.ts
1711
- var InfoBar = class {
1712
- constructor(opts) {
1713
- /** Defaults **/
1714
- //Color shown on the left of the color scale
1715
- this.startColor = "white";
1716
- //Color shown on the right of the color scale
1717
- this.endColor = "red";
1718
- this.addLabel = (text) => {
1719
- return this.labelRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toLowerCase().replace(/\s/g, "-")}-label`).style("color", "#858585").style("font-size", ".8em").style("text-align", "center").style("vertical-align", "middle").text(text.toUpperCase());
1720
- };
1721
- this.addValue = (text) => {
1722
- return this.valueRow.append("td").attr("data-testid", `sjpp-hic-infobar-${text.toString().toLowerCase().replace(/\s/g, "-")}-value`).style("font-size", "1em").style("text-align", "center").style("vertical-align", "middle").text(text);
1723
- };
1724
- this.type = "infoBar";
1725
- this.app = opts.app;
1726
- this.hic = opts.hic;
1727
- const table = opts.infoBarDiv;
1728
- this.labelRow = table.append("tr");
1729
- this.valueRow = table.append("tr");
1730
- this.parent = opts.parent;
1731
- }
1732
- async render() {
1733
- this.addLabel("Version");
1734
- this.addValue(this.hic.version);
1735
- this.addLabel("Enzyme");
1736
- this.addValue(this.hic.enzyme || "N/A");
1737
- this.addLabel("Resolution");
1738
- this.resolutionDiv = this.addValue("");
1739
- this.colorScaleLabel = this.addLabel("Scale");
1740
- this.colorScaleDiv = this.valueRow.append("td").attr("data-testid", "sjpp-hic-color-scale");
1741
- const min = this.parent("min");
1742
- let max = this.parent("max");
1743
- if (min == max) max = max + 0.01;
1744
- this.colorScale = new ColorScale({
1745
- barheight: 20,
1746
- barwidth: 100,
1747
- domain: [min, max],
1748
- fontSize: 12,
1749
- height: 40,
1750
- width: 150,
1751
- holder: this.colorScaleDiv,
1752
- colors: [this.startColor, this.endColor],
1753
- position: "20,0",
1754
- ticks: 3,
1755
- tickSize: 5,
1756
- //Do not use min value here on initialization. It's 0 and will not update later.
1757
- markedValue: 1
1758
- });
1759
- }
1760
- update() {
1761
- const res = this.parent("calcResolution");
1762
- let resolutionText;
1763
- if (res < this.hic.bpresolution[this.hic.bpresolution.length - 1]) {
1764
- resolutionText = `${res} fragment${res > 1 ? "s" : ""}`;
1765
- } else {
1766
- resolutionText = bplen(res);
1767
- }
1768
- this.resolutionDiv.text(resolutionText);
1769
- if (this.parent("state").currView == "horizontal") {
1770
- this.colorScaleLabel.style("display", "none");
1771
- this.colorScaleDiv.style("display", "none");
1772
- } else {
1773
- this.colorScaleLabel.style("display", "");
1774
- this.colorScaleDiv.style("display", "");
1775
- const min = this.parent("min");
1776
- const max = this.parent("max");
1777
- if (min < 0) {
1778
- this.colorScale.colors = ["blue", "white", "red"];
1779
- this.colorScale.domain = [min, 0, max];
1780
- } else {
1781
- this.colorScale.colors = ["white", "red"];
1782
- this.colorScale.domain = [0, max];
1783
- }
1784
- this.colorScale.markedValue = min;
1785
- this.colorScale.updateScale();
1786
- }
1787
- }
1788
- };
1789
-
1790
- // tracks/hic/data/DataMapper.ts
1791
- var DataMapper = class {
1792
- constructor(hic, percentile) {
1793
- this.hic = hic;
1794
- this.percentile = percentile ? percentile / 100 : 0.99;
1795
- }
1796
- sortData(data) {
1797
- const vlst = [];
1798
- if (data?.items && data?.items.length) {
1799
- for (const i of data.items) {
1800
- vlst.push(i[2]);
1801
- }
1802
- } else {
1803
- const blankChrs = /* @__PURE__ */ new Set();
1804
- for (const d of data) {
1805
- if (d.lead == "chrM" && !d.items.length || d.lead == "chrY" && !d.items.length) {
1806
- blankChrs.add(d.lead);
1807
- continue;
1808
- }
1809
- for (const i of d.items) {
1810
- vlst.push(i[2]);
1811
- }
1812
- }
1813
- if (blankChrs.size) {
1814
- for (const c of blankChrs) {
1815
- const idx = this.hic.chrlst.indexOf(c);
1816
- this.hic.chrlst.splice(idx, 1);
1817
- }
1818
- }
1819
- }
1820
- const sortedVlst = vlst.sort((a, b) => a - b);
1821
- const max = sortedVlst[Math.floor(sortedVlst.length * this.percentile)];
1822
- const min = sortedVlst[0];
1823
- return [min, max, sortedVlst[sortedVlst.length - 1]];
1824
- }
1825
- };
1826
-
1827
- // tracks/hic/data/GenomeDataFetcher.ts
1828
- var GenomeDataFetcher = class {
1829
- constructor(hic, debugmode, errList = []) {
1830
- this.data = [];
1831
- this.hic = hic;
1832
- this.debugmode = debugmode;
1833
- this.errList = errList || [];
1834
- }
1835
- async getData(obj) {
1836
- if (this.data.length) this.data = [];
1837
- if (!obj?.matrixType) obj.matrixType = "observed";
1838
- try {
1839
- const res = await dofetch3("hicgenome?", {
1840
- method: "POST",
1841
- body: JSON.stringify({
1842
- chrlst: this.hic.chrlst,
1843
- nmeth: obj.nmeth,
1844
- resolution: obj.resolution,
1845
- matrixType: obj.matrixType,
1846
- file: this.hic.file,
1847
- url: this.hic.url,
1848
- nochr: this.hic.nochr
1849
- })
1850
- });
1851
- if (res.error) {
1852
- const errs = res.error.split("\n");
1853
- for (const e of errs) {
1854
- this.errList.push(e);
1855
- }
1856
- }
1857
- return res.data;
1858
- } catch (e) {
1859
- this.errList.push(e.message || e);
1860
- if (e.stack) console.error(e.stack);
1861
- }
1862
- }
1863
- };
1864
-
1865
- // tracks/hic/data/DataFetcher.ts
1866
- var DataFetcher = class {
1867
- constructor(hic, debugmode, errList = []) {
1868
- this.hic = hic;
1869
- this.debugmode = debugmode;
1870
- this.errList = errList || [];
1871
- }
1872
- async getData(obj) {
1873
- if (!obj?.matrixType) obj.matrixType = "observed";
1874
- const arg = {
1875
- matrixType: obj.matrixType,
1876
- file: this.hic.file,
1877
- url: this.hic.url,
1878
- pos1: this.hic.nochr ? obj.lead.replace("chr", "") : obj.lead,
1879
- pos2: this.hic.nochr ? obj.follow.replace("chr", "") : obj.follow,
1880
- nmeth: obj.nmeth,
1881
- resolution: obj.resolution
1882
- };
1883
- try {
1884
- const data = await dofetch3("hicdata?", {
1885
- method: "POST",
1886
- body: JSON.stringify(arg)
1887
- });
1888
- if (data.error) {
1889
- throw Error(`${obj.lead} - ${obj.follow}: ${data.error.error}`);
1890
- }
1891
- if (!data.items || data.items.length == 0) return;
1892
- return data;
1893
- } catch (e) {
1894
- this.errList.push(e.message || e);
1895
- if (e.stack) console.error(e.stack);
1896
- }
1897
- }
1898
- };
1899
-
1900
- // tracks/hic/HicComponent.ts
1901
- var HicComponent = class _HicComponent {
1902
- constructor(opts) {
1903
- this.genomeData = [];
1904
- this.calcResolution = null;
1905
- this.firstRender = true;
1906
- this.min = 0;
1907
- this.absMin = 0;
1908
- this.max = 0;
1909
- this.absMax = 0;
1910
- this.hasStatePreMain = true;
1911
- this.type = _HicComponent.type;
1912
- this.hic = opts.hic;
1913
- this.state = opts.state;
1914
- this.dom = opts.dom;
1915
- this.errList = opts.errList;
1916
- this.plotDiv = this.dom.plotDiv.append("table").classed("sjpp-hic-plot-main", true);
1917
- const tr1 = this.plotDiv.append("tr");
1918
- const tr2 = this.plotDiv.append("tr");
1919
- this.plotDiv = {
1920
- plot: tr1.append("td").classed("sjpp-hic-plot", true).attr("data-testid", "sjpp-hic-plot"),
1921
- yAxis: tr1.append("td").classed("sjpp-hic-plot-yaxis", true).attr("data-testid", "sjpp-hic-yaxis"),
1922
- xAxis: tr2.append("td").classed("sjpp-hic-plot-xaxis", true).attr("data-testid", "sjpp-hic-xaxis"),
1923
- blank: tr2.append("td")
1924
- };
1925
- this.app = opts.app;
1926
- this.dataMapper = new DataMapper(this.hic, opts.state.maxCutoffPercentile);
1927
- this.activeView = this.state.currView;
1928
- this.error = opts.error;
1929
- this.resolution = new Resolution(this.error);
1930
- this.parent = (prop) => {
1931
- return this[prop];
1932
- };
1933
- this.detailDataMapper = new DetailDataMapper(this.hic, this.errList, this.parent);
1934
- }
1935
- static {
1936
- this.type = "view";
1937
- }
1938
- getState(appState) {
1939
- return appState;
1940
- }
1941
- reactsTo(action) {
1942
- if (action.type.startsWith("view")) return true;
1943
- else return false;
1944
- }
1945
- initView() {
1946
- const opts = {
1947
- plotDiv: this.plotDiv,
1948
- hic: this.hic,
1949
- app: this.app,
1950
- parent: (prop) => {
1951
- return this[prop];
1952
- }
1953
- };
1954
- if (this.state.currView == "genome") {
1955
- opts["data"] = this.data;
1956
- this.genome = new GenomeView(opts);
1957
- this.genome.render();
1958
- } else if (this.state.currView === "chrpair") {
1959
- opts["items"] = this.data;
1960
- this.chrpair = new ChrPairView(opts);
1961
- this.chrpair.render();
1962
- } else if (this.state.currView === "detail") {
1963
- opts["data"] = this.data;
1964
- this.detail = new DetailView(opts);
1965
- this.detail.render();
1966
- } else if (this.state.currView === "horizontal") {
1967
- this.horizontal = new HorizontalView(opts);
1968
- this.horizontal.render();
1969
- } else {
1970
- throw Error(`Unknown view: ${this.state.currView}`);
1971
- }
1972
- }
1973
- async fetchData(obj) {
1974
- if (this.data?.length) this.data = [];
1975
- if (this.state.currView == "genome") {
1976
- if (this.activeView != "genome" && this.genomeData?.length) this.data = this.genomeData;
1977
- else {
1978
- const genomeFetcher = new GenomeDataFetcher(this.hic, true, this.errList);
1979
- this.genomeData = await genomeFetcher.getData(obj);
1980
- this.data = this.genomeData;
1981
- }
1982
- } else if (this.state.currView == "detail") {
1983
- this.data = await this.detailDataMapper.getData(this.state.x, this.state.y, this.fragData);
1984
- } else {
1985
- if (!this.state?.x?.chr || !this.state?.y?.chr) {
1986
- this.errList.push(`No positions provided for ${this.activeView} view.`);
1987
- return;
1988
- } else {
1989
- const chrx = this.state.x;
1990
- const chry = this.state.y;
1991
- obj["lead"] = `${chrx.start && chrx.stop ? `${chrx.chr}:${chrx.start}-${chrx.stop}` : chrx.chr}`;
1992
- obj["follow"] = `${chry.start && chry.stop ? `${chry.chr}:${chry.start}-${chry.stop}` : chry.chr}`;
1993
- }
1994
- const dataFetcher = new DataFetcher(this.hic, true, this.errList);
1995
- this.data = await dataFetcher.getData(obj);
1996
- }
1997
- }
1998
- async setResolution(appState) {
1999
- const state = this.app.getState(appState);
2000
- this.calcResolution = this.resolution.getResolution(state, this.hic);
2001
- if (state.currView == "detail" && this.calcResolution == null) {
2002
- await this.detailDataMapper.getFragData(state.x, state.y);
2003
- this.fragData = this.detailDataMapper.frag;
2004
- const maxFragSpan = Math.min(
2005
- this.fragData.x.stop - this.fragData.x.start,
2006
- this.fragData.y.stop - this.fragData.y.start
2007
- );
2008
- this.calcResolution = this.resolution.findResFromArray(
2009
- maxFragSpan,
2010
- state.minFragSpan,
2011
- this.hic.fragresolution,
2012
- true
2013
- );
2014
- } else {
2015
- this.fragData = null;
2016
- }
2017
- return this.calcResolution;
2018
- }
2019
- async setDataArgs(appState) {
2020
- const state = this.app.getState(appState);
2021
- const currView = state[state.currView];
2022
- const args = {
2023
- nmeth: currView.nmeth,
2024
- resolution: await this.setResolution(appState),
2025
- matrixType: currView.matrixType
2026
- };
2027
- if (state.currView == "chrpair") {
2028
- args["lead"] = state.x.chr;
2029
- args["follow"] = state.y.chr;
2030
- }
2031
- return args;
2032
- }
2033
- async getViewData(appState) {
2034
- const args = await this.setDataArgs(appState);
2035
- await this.fetchData(args);
2036
- if (this.data?.length > 0 || this.data?.items?.length > 0) {
2037
- const [min, max, absMax] = this.dataMapper.sortData(this.data);
2038
- this.min = this.absMin = min;
2039
- this.max = max;
2040
- this.absMax = absMax;
2041
- } else {
2042
- if (this.state.currView != "genome") {
2043
- const state = this.app.getState(appState);
2044
- const xPosMessage = state.x?.start ? `${state.x.chr}:${state.x.start}-${state.x.stop}` : state.x.chr;
2045
- const yPosMessage = state.y?.start ? `${state.y.chr}:${state.y.start}-${state.y.stop}` : state.y.chr;
2046
- this.errList.push(`No data returned for ${xPosMessage} and ${yPosMessage}`);
2047
- }
2048
- }
2049
- }
2050
- async init() {
2051
- this.components = {
2052
- controls: await controlPanelInit({
2053
- app: this.app,
2054
- controlsDiv: this.dom.controlsDiv,
2055
- hic: this.hic,
2056
- parent: (prop, value) => {
2057
- if (value) this[prop] = value;
2058
- return this[prop];
2059
- },
2060
- error: this.error.bind(this)
2061
- })
2062
- };
2063
- this.infoBar = new InfoBar({
2064
- app: this.app,
2065
- infoBarDiv: this.dom.infoBarDiv.append("table").style("border-spacing", "3px"),
2066
- hic: this.hic,
2067
- parent: (prop) => {
2068
- return this[prop];
2069
- }
2070
- });
2071
- this.infoBar.render();
2072
- }
2073
- async main(appState) {
2074
- if (this.errList.length) {
2075
- this.app.dispatch({ type: "loading_active", active: false });
2076
- return;
2077
- }
2078
- const state = this.app.getState(appState);
2079
- if (this.firstRender == true) {
2080
- this.firstRender = false;
2081
- await this.getViewData(appState);
2082
- this.initView();
2083
- } else {
2084
- if (state.currView != "horizontal") {
2085
- this.app.dispatch({ type: "loading_active", active: true });
2086
- await this.getViewData(appState);
2087
- }
2088
- if (this.activeView != state.currView) {
2089
- if (this.activeView == "genome") {
2090
- this.genome.svg.remove();
2091
- } else {
2092
- this.plotDiv.xAxis.selectAll("*").remove();
2093
- this.plotDiv.yAxis.selectAll("*").remove();
2094
- this.plotDiv.plot.selectAll("*").remove();
2095
- }
2096
- this.activeView = state.currView;
2097
- this.initView();
2098
- } else {
2099
- this[state.currView].update(this.data);
2100
- }
2101
- }
2102
- this.infoBar.update();
2103
- if (this.errList.length) {
2104
- this.error(this.errList);
2105
- this.app.dispatch({ type: "loading_active", active: false });
2106
- }
2107
- }
2108
- };
2109
- var viewCompInit = getCompInit(HicComponent);
2110
-
2111
- // tracks/hic/HicApp.ts
2112
- var HicApp = class _HicApp extends AppBase {
2113
- constructor(opts) {
2114
- super(opts);
2115
- this.views = ["genome", "chrpair", "detail", "horizontal"];
2116
- this.errList = [];
2117
- /** Required for rx but not in use */
2118
- this.wasDestroyed = false;
2119
- this.type = _HicApp.type;
2120
- this.hic = {
2121
- enzyme: opts.enzyme,
2122
- file: opts.file,
2123
- url: opts.url,
2124
- genome: opts.genome,
2125
- holder: opts.holder,
2126
- hostUrl: opts.hostUrl,
2127
- jwt: opts.jwt,
2128
- position1: opts.position1,
2129
- position2: opts.position2,
2130
- maxCutoffPercentile: opts.maxCutoffPercentile,
2131
- name: "name" in opts ? opts.name : "Hi-C",
2132
- tklist: "tklst" in opts ? opts.tklst : [],
2133
- state: "state" in opts ? opts.state : {}
2134
- };
2135
- this.dom = {
2136
- errorDiv: opts.holder.append("div").classed("sjpp-hic-error", true),
2137
- controlsDiv: opts.holder.append("div").classed("sjpp-hic-controls", true).style("display", "inline-block"),
2138
- infoBarDiv: opts.holder.append("div").classed("sjpp-hic-infobar", true).style("display", "inline-block").style("vertical-align", "top").style("padding", "5px").style("border", "solid 0.5px #ccc"),
2139
- loadingDiv: select_default("body").append("div").attr("id", "sjpp-loading-overlay"),
2140
- plotDiv: opts.holder.append("div").classed("sjpp-hic-main", true).style("display", "inline-block"),
2141
- tip: new Menu()
2142
- };
2143
- }
2144
- static {
2145
- this.type = "app";
2146
- }
2147
- async error(err) {
2148
- if (err && typeof err == "string") this.errList.push(err);
2149
- showErrorsWithCounter(this.errList, this.dom.errorDiv);
2150
- this.errList = [];
2151
- }
2152
- determineView() {
2153
- if (!this.hic.position1 && !this.hic.position2 && !this.hic.state.currView) this.hic.state.currView = "genome";
2154
- if (!this.hic.position1 && this.hic.position2) this.errList.push("Missing first position");
2155
- if (this.hic.position1 && !this.hic.position2) this.errList.push("Missing second position");
2156
- if (this.hic.position1 && this.hic.position2) {
2157
- const pos1 = this.hic.position1.split(/[:-]/);
2158
- const pos2 = this.hic.position2.split(/[:-]/);
2159
- this.hic.state.x = { chr: pos1[0] };
2160
- this.hic.state.y = { chr: pos2[0] };
2161
- if (!Number.isNaN(+pos1[1]) && !Number.isNaN(+pos1[2])) {
2162
- this.hic.state.x.start = +pos1[1];
2163
- this.hic.state.x.stop = +pos1[2];
2164
- this.hic.state.y.start = +pos2[1];
2165
- this.hic.state.y.stop = +pos2[2];
2166
- this.hic.state.currView = "detail";
2167
- } else {
2168
- this.hic.state.currView = "chrpair";
2169
- }
2170
- } else {
2171
- if (!this.views.some((v) => v === this.hic.state.currView)) this.error(`Unknown view: ${this.hic.state.currView}`);
2172
- else return this.hic.state.currView;
2173
- }
2174
- }
2175
- getViewsConfig() {
2176
- if (this.hic.maxCutoffPercentile) this.hic.state.maxCutoffPercentile = this.hic.maxCutoffPercentile;
2177
- let nmeth;
2178
- if (this.hic["normalization"]?.length > 0) {
2179
- if (!this.hic["normalization"].includes("NONE")) this.hic["normalization"].unshift("NONE");
2180
- nmeth = this.hic["normalization"][0];
2181
- } else {
2182
- nmeth = "NONE";
2183
- }
2184
- if (this.hic.state.currView) {
2185
- if (!this.hic.state[this.hic.state.currView]) this.hic.state[this.hic.state.currView] = {};
2186
- if (!this.hic.state[this.hic.state.currView]?.matrixType) {
2187
- this.hic.state[this.hic.state.currView].matrixType = "observed";
2188
- }
2189
- if (!this.hic.state[this.hic.state.currView]?.nmeth) {
2190
- this.hic.state[this.hic.state.currView].nmeth = nmeth;
2191
- }
2192
- }
2193
- for (const v of this.views) {
2194
- if (!this.hic.state[v]) {
2195
- this.hic.state[v] = {
2196
- matrixType: "observed",
2197
- nmeth
2198
- };
2199
- }
2200
- }
2201
- }
2202
- async init() {
2203
- this.determineView();
2204
- try {
2205
- await hicParseFile(this.hic, true, this.errList);
2206
- this.getViewsConfig();
2207
- this.store = await hicStoreInit({ app: this.api, state: this.hic.state });
2208
- this.state = await this.store.copyState();
2209
- this.components = {
2210
- loadingOverlay: await loadingInit({
2211
- app: this.api,
2212
- loadingDiv: this.dom.loadingDiv
2213
- }),
2214
- view: await viewCompInit({
2215
- app: this.api,
2216
- state: this.state,
2217
- dom: this.dom,
2218
- hic: this.hic,
2219
- errList: this.errList,
2220
- error: this.error
2221
- })
2222
- };
2223
- await this.api.dispatch();
2224
- } catch (e) {
2225
- console.error(e.stack || e);
2226
- }
2227
- }
2228
- main() {
2229
- if (this.errList.length) {
2230
- this.error(this.errList);
2231
- this.dom.loadingDiv.style("display", "none");
2232
- return;
2233
- }
2234
- }
2235
- };
2236
- var hicInit = getAppInit(HicApp);
2237
- export {
2238
- hicInit
2239
- };
2240
- //# sourceMappingURL=HicApp-ZGZKO4Y4.js.map