@sjcrh/proteinpaint-client 2.212.0 → 2.213.0

package/dist/chunk-BUX5YSDF.js

@@ -0,0 +1,56 @@
+import {
+  sayerror
+} from "./chunk-QI6X4V43.js";
+import {
+  TermTypeGroups
+} from "./chunk-57Z4VYLM.js";
+
+// termdb/handlers/singleCellNumericValue.ts
+var SearchHandler = class {
+  async init(opts) {
+    this.validateOpts(opts);
+    this.callback = opts.callback;
+    this.app = opts.app;
+    const holder = opts.holder.append("div").style("padding", "10px 0px");
+    const scnvTerms = opts.app.vocabApi.termdbConfig?.termType2terms?.[TermTypeGroups.SINGLECELL_NUMERIC_VALUE];
+    if (!scnvTerms?.length) {
+      sayerror(
+        holder,
+        `termType2terms[${TermTypeGroups.SINGLECELL_NUMERIC_VALUE}]:[] is required in termdbConfig for singleCellNumericValue handler`
+      );
+      return;
+    }
+    const usecaseConfig = opts.usecase?.specialCase?.config;
+    const plots = usecaseConfig?.sample?.plots;
+    const isMeta = usecaseConfig?.sample?.isMetaResult;
+    const filtered = plots ? scnvTerms.filter((t) => plots.includes(t.plot)) : usecaseConfig?.name ? scnvTerms.filter((t) => t.plot === usecaseConfig.name) : scnvTerms;
+    const getLabel = (t) => isMeta || plots?.length == 1 ? t.name : `${t.name} (${t.plot})`;
+    const filteredTerms = new Set(
+      plots || !usecaseConfig?.name ? filtered.map((t) => ({ ...t, label: getLabel(t) })) : filtered
+    );
+    for (const t of Array.from(filteredTerms)) {
+      holder.append("div").classed("termdiv", true).style("padding", "0px 5px").append("div").classed("termlabel sja_filter_tag_btn sja_tree_click_term ts_pill", true).style("display", "inline-block").style("padding", "5px 8px").style("margin", "1px 0px").style("border-radius", "6px").text(t.label || t.name).on("click", () => {
+        const term = this.makeTerm(t, usecaseConfig);
+        this.callback(term);
+      });
+    }
+  }
+  makeTerm(_term, usecaseConfig) {
+    const term = { ..._term };
+    if (!term.sample && usecaseConfig?.sample) term.sample = usecaseConfig.sample;
+    return term;
+  }
+  validateOpts(opts) {
+    if (opts.callback == null) throw new Error("callback is required");
+    if (opts.app == null) throw new Error("app is required");
+    if (opts.holder == null) throw new Error("holder is required");
+    if (opts.usecase == null) throw new Error("usecase is required");
+    if (!opts.app.vocabApi.termdbConfig?.termType2terms)
+      throw new Error("termType2terms is required in termdbConfig for singleCellNumericValue handler");
+  }
+};
+
+export {
+  SearchHandler
+};
+//# sourceMappingURL=chunk-BUX5YSDF.js.map

package/dist/chunk-C2KMMY53.js

@@ -0,0 +1,339 @@
+import {
+  summaryInit
+} from "./chunk-3SBHDIJU.js";
+import {
+  navInit
+} from "./chunk-GDJUSLDV.js";
+import {
+  skipPrevActionAbort,
+  storeInit
+} from "./chunk-QZXUHBUV.js";
+import {
+  AppBase,
+  downloadSVGsAsPdf,
+  filterRxCompInit,
+  newSandboxDiv,
+  sayerror,
+  vocabInit
+} from "./chunk-QI6X4V43.js";
+import {
+  importPlot
+} from "./chunk-7HPICVA4.js";
+import {
+  Menu
+} from "./chunk-7XZA2XR2.js";
+import {
+  AppApi,
+  getCompInit,
+  multiInit
+} from "./chunk-HBNB5TRH.js";
+import {
+  select_default
+} from "./chunk-I6Y4O3RR.js";
+
+// mass/plot.js
+var MassPlot = class _MassPlot {
+  static type = "plot";
+  constructor(opts) {
+    this.type = _MassPlot.type;
+    setRenderers(this);
+    this.initUi(opts);
+  }
+  reactsTo(action) {
+    if (action.type.endsWith("_group")) return true;
+    if (action.type.startsWith("plot_")) {
+      return action.id === this.id || action.id == this.parentId || action.config?.parentId === this.id || action.parentId === this.id;
+    }
+    if (action.type.startsWith("filter")) return true;
+    if (action.type.startsWith("cohort")) return true;
+    if (action.type == "app_refresh") return true;
+    if (action.type.endsWith("customTerm")) return true;
+  }
+  // !!! NOTE: This getState() method is reused by the plot-specific recover component.
+  // When logging something within getState, it may have been called by either the plot or recover instance
+  getState(appState) {
+    const config = appState.plots.find((p) => p.id === this.id);
+    if (!config) {
+      throw `No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`;
+    }
+    return {
+      termfilter: appState.termfilter,
+      config,
+      groups: appState.groups,
+      // quick fix to skip history tracking as needed
+      _scope_: appState._scope_
+    };
+  }
+  async main() {
+    this.dom.errdiv.style("display", "none").style("background-color", "rgba(255,100,100,0.2)").html("");
+    if (!this.components) await this.setComponents(this.opts);
+  }
+  async setComponents(opts) {
+    const _ = await importPlot(opts.chartType);
+    const promises = {
+      // recover: recoverInit({
+      // 	app: this.app,
+      // 	holder: this.dom.localRecoverDiv,
+      // 	getState: appState => this.getState(appState),
+      // 	reactsTo: action =>
+      // 		action.id == this.id &&
+      // 		(action.type == 'plot_edit' || action.type == 'plot_nestedEdits') &&
+      // 		action._track_ != 'none',
+      // 	plot_id: this.id,
+      // 	maxHistoryLen: 10,
+      // 	hideLabel: true
+      // }),
+      chart: _.componentInit({
+        app: this.app,
+        holder: this.dom.viz,
+        header: this.dom.paneTitleDiv,
+        id: this.id,
+        plotDiv: select_default(this.dom.holder.app_div.node().parentNode),
+        /******* reason for passing plotDiv to chart ********
+        				- this plot instance may allow to launch a new plot as a persistent sandbox
+        				  inside mass plotDiv, maintaining the uniform plot appearance despite it's ad-hoc
+        				  the new plot is not a formal mass plot type, and cannot be done via app.dispatch()
+        				  thus the need to directly access plotDiv
+        				- example: mds3 tk from genome browser can launch disco etc
+        				- having access to plotDiv may offer flexibility for the plot to do stuff
+        
+        				since plot.js has no access to mass app .dom.plotDiv in which all apps are shown,
+        				this workarounds gets the parent node of sandbox.app_div which is app.dom.plotDiv
+        				*/
+        getFilterImage: async () => this.components.filter.getFilterImage()
+      })
+    };
+    if (!this.state.config.hidePlotFilter) {
+      const filterDisabledMsg = this.app.vocabApi.termdbConfig?.plotFilter?.disabledMessage;
+      const filterHolder = filterDisabledMsg ? this.dom.filterDiv.append("div").style("pointer-events", "none").style("opacity", 0.5) : this.dom.filterDiv;
+      if (filterDisabledMsg) this.dom.filterDiv.attr("title", filterDisabledMsg).style("cursor", "not-allowed");
+      promises.filter = filterRxCompInit({
+        app: this.app,
+        vocabApi: this.app.vocabApi,
+        parentId: this.id,
+        holder: filterHolder,
+        hideLabel: true,
+        emptyLabel: "+Add new filter",
+        callback: (filter) => {
+          this.app.dispatch({
+            id: this.id,
+            type: "plot_edit",
+            config: { filter }
+          });
+        }
+      });
+    }
+    this.components = await multiInit(promises);
+  }
+  destroy() {
+    this.dom.holder.app_div.selectAll("*").remove();
+    this.dom.holder.app_div.remove();
+    for (const key in this.dom) {
+      delete this.dom[key];
+    }
+  }
+};
+var plotInit = getCompInit(MassPlot);
+function setRenderers(self) {
+  self.initUi = function(opts) {
+    const holder = opts.holder;
+    opts.holder.app_div.attr("data-testid", "sjpp-massplot-sandbox-" + opts.chartType);
+    holder.header.style("padding", 0);
+    try {
+      self.dom = {
+        tip: new Menu({ padding: "0px" }),
+        holder,
+        paneTitleDiv: holder.header.append("div").style("display", "inline-block").style("color", "#555").style("padding-left", "7px").style("vertical-align", "sub"),
+        localRecoverDiv: holder.header.append("div").style("display", "inline-block"),
+        filterDiv: holder.header.append("div").style("display", "inline-block").style("zoom", 0.9),
+        body: holder.body.style("white-space", "nowrap").style("overflow-x", "auto"),
+        // will hold no data notice or the page title in multichart views
+        errdiv: holder.body.append("div").style("display", "none").style("padding", "5px").style("background-color", "rgba(255,100,100,0.2)"),
+        // dom.viz will hold the rendered view
+        viz: holder.body.append("div")
+      };
+    } catch (e) {
+      self.dom.errdiv.style("display", "none").text(e);
+    }
+  };
+}
+
+// mass/app.ts
+var MassApp = class extends AppBase {
+  // expected class-specific props
+  constructor(opts, api) {
+    super(opts);
+    this.components = {};
+    this.wasDestroyed = false;
+    this.api = api;
+    if (opts.addLoginCallback) {
+      opts.addLoginCallback(() => this.api.dispatch({ type: "app_refresh" }));
+    }
+    this.type = "app";
+    this.dom = {
+      holder: opts.holder,
+      // do not modify holder style
+      topbar: opts.holder.append("div"),
+      errdiv: opts.holder.append("div"),
+      plotDiv: opts.holder.append("div")
+    };
+    if (opts.getPlotConfig_mutateSummary) {
+      if (typeof opts.getPlotConfig_mutateSummary != "function")
+        throw new Error("opts.getPlotConfig_mutateSummary is not function");
+    }
+    this.plotIdToSandboxId = {};
+  }
+  static {
+    this.type = "app";
+  }
+  async preApiFreeze(api) {
+    try {
+      api.tip = new Menu({ padding: "5px" });
+      api.tip.d.on("keyup", (event) => {
+        if (event.key == "Escape") api.tip.hide();
+      });
+      api.printError = (e) => this.printError(e);
+      api.vocabApi = await vocabInit({
+        app: api,
+        state: { vocab: this.opts.state.vocab },
+        fetchOpts: this.opts.fetchOpts,
+        getDatasetAccessToken: this.opts.getDatasetAccessToken
+      });
+      api.hasWebGL = function() {
+        try {
+          const canvas = document.createElement("canvas");
+          return !!(window.WebGLRenderingContext && (canvas.getContext("webgl") || canvas.getContext("experimental-webgl")));
+        } catch (_) {
+          return false;
+        }
+      };
+      this.opts.state.vocab = api.vocabApi.vocab;
+    } catch (e) {
+      console.log(`preApiFreeze error`, e);
+      throw e;
+    }
+  }
+  async init() {
+    try {
+      const debounceInterval = "debounceInterval" in this.opts ? this.opts.debounceInterval : 0;
+      const embeddedSessionState = this.opts.embeddedSessionState;
+      if (embeddedSessionState) {
+        Object.assign(this.opts.state, embeddedSessionState);
+      }
+      this.store = await storeInit({ app: this.api, state: this.opts.state, debounceInterval });
+      this.state = await this.store.copyState();
+      this.components = {};
+      if (this.state.nav.header_mode != "hidden") {
+        this.components.nav = await navInit({
+          app: this.api,
+          holder: this.dom.topbar,
+          header_mode: this.state && this.state.nav && this.state.nav.header_mode,
+          vocab: this.state.vocab,
+          massSessionDuration: this.state.termdbConfig.massSessionDuration,
+          // this.opts.massSessionDuration
+          pkgver: this.opts.pkgver,
+          downloadPlots: () => {
+            this.downloadPlots();
+          }
+        });
+      }
+      this.components.plots = {};
+      if (this.opts.app?.doNotAwaitInitRender) {
+        this.api.dispatch();
+      } else {
+        await this.api.dispatch();
+      }
+    } catch (e) {
+      this.printError(e);
+      throw e;
+    }
+  }
+  async main() {
+    await this.api.vocabApi.main();
+    this.dom.plotDiv?.style(
+      "display",
+      this.state.nav?.header_mode != "hidden" && this.state.nav?.activeTab == 0 ? "none" : "block"
+    );
+    const newPlots = {};
+    let sandbox;
+    for (const plot of this.state.plots) {
+      if (plot.parentId) continue;
+      if (this.components.plots && !(plot.id in this.components.plots)) {
+        sandbox = newSandboxDiv(this.dom.plotDiv, {
+          close: () => {
+            this.api.dispatch({
+              type: "plot_delete",
+              id: plot.id
+            });
+          },
+          plotId: plot.id,
+          beforePlotId: plot.insertBefore || null,
+          style: {
+            width: "98.5%"
+          }
+        });
+        if (plot.chartType == "summary")
+          newPlots[plot.id] = summaryInit(Object.assign({ app: this.api, holder: sandbox }, plot));
+        else newPlots[plot.id] = plotInit(Object.assign({ app: this.api, holder: sandbox }, plot));
+      }
+    }
+    const numNewPlots = Object.keys(newPlots).length;
+    if (numNewPlots) {
+      await Promise.all(Object.values(newPlots));
+      for (const plotId in newPlots) {
+        this.components.plots[plotId] = await newPlots[plotId];
+      }
+    }
+    for (const plotId in this.components.plots) {
+      if (!this.state.plots.find((p) => p.id === plotId)) {
+        this.components.plots[plotId].destroy();
+        delete this.components.plots[plotId];
+      }
+    }
+  }
+  printError(e) {
+    const errdiv = e.errdiv || this.dom.errdiv;
+    if (errdiv) errdiv.style("display", "").html("").style("background-color", "");
+    sayerror(errdiv || this.opts.holder, "Error: " + (e.message || e.error || e));
+    if (e.stack) console.log(e.stack);
+    this.bus.emit("error");
+    if (this.opts?.debug) {
+      console.groupCollapsed("Stack trace from MassApp.printError() call.");
+      console.trace();
+      console.groupEnd();
+    }
+  }
+  skipPrevActionAbort(action) {
+    return skipPrevActionAbort(action);
+  }
+  async downloadPlots() {
+    const chartImagesAll = [];
+    let i = 1;
+    const values = Object.values(this.components.plots);
+    for (const plot of values) {
+      const chart = plot.type == "plot" ? plot.getComponents("chart") : plot;
+      const chartImages = chart.getChartImages ? chart.getChartImages() : null;
+      if (!chartImages) {
+        console.log(`The ${chart.type} does not support downloading images yet`);
+        continue;
+      }
+      for (const chartImage of chartImages) {
+        if (values.length > 1) chartImage.name = `${i}. ${chartImage.name}`;
+        chartImagesAll.push(chartImage);
+      }
+      i++;
+    }
+    if (chartImagesAll.length > 0) {
+      const filters = [];
+      const globalFilterImg = await this.components.nav.getComponents("filter").getFilterImage();
+      if (globalFilterImg) filters.push(globalFilterImg);
+      downloadSVGsAsPdf(chartImagesAll, "plots", "landscape", filters);
+    } else alert("No chart images available for download");
+  }
+};
+var appInit = AppApi.getInitFxn(MassApp);
+
+export {
+  appInit
+};
+//# sourceMappingURL=chunk-C2KMMY53.js.map

package/dist/chunk-CD2WD7ZG.js

@@ -0,0 +1,56 @@
+import {
+  sayerror
+} from "./chunk-QI6X4V43.js";
+import {
+  TermTypeGroups
+} from "./chunk-57Z4VYLM.js";
+
+// termdb/handlers/singleCellCellType.ts
+var SearchHandler = class {
+  async init(opts) {
+    this.validateOpts(opts);
+    this.callback = opts.callback;
+    this.app = opts.app;
+    const holder = opts.holder.append("div").style("padding", "10px 0px");
+    const scctTerms = opts.app.vocabApi.termdbConfig?.termType2terms?.[TermTypeGroups.SINGLECELL_CELLTYPE];
+    if (!scctTerms?.length) {
+      sayerror(
+        holder,
+        `termType2terms[${TermTypeGroups.SINGLECELL_CELLTYPE}]:[] is required in termdbConfig for singleCellCellType handler`
+      );
+      return;
+    }
+    const usecaseConfig = opts.usecase?.specialCase?.config;
+    const plots = usecaseConfig?.sample?.plots;
+    const isMeta = usecaseConfig?.sample?.isMetaResult;
+    const filtered = plots ? scctTerms.filter((t) => plots.includes(t.plot)) : usecaseConfig?.name ? scctTerms.filter((t) => t.plot === usecaseConfig.name) : scctTerms;
+    const getLabel = (t) => isMeta || plots?.length == 1 ? t.name : `${t.name} (${t.plot})`;
+    const filteredTerms = new Set(
+      plots || !usecaseConfig?.name ? filtered.map((t) => ({ ...t, label: getLabel(t) })) : filtered
+    );
+    for (const t of Array.from(filteredTerms)) {
+      holder.append("div").classed("termdiv", true).style("padding", "0px 5px").append("div").classed("termlabel sja_filter_tag_btn sja_tree_click_term ts_pill", true).style("display", "inline-block").style("padding", "5px 8px").style("margin", "1px 0px").style("border-radius", "6px").text(t.label || t.name).on("click", () => {
+        const term = this.makeTerm(t, usecaseConfig);
+        this.callback(term);
+      });
+    }
+  }
+  makeTerm(_term, usecaseConfig) {
+    const term = { ..._term };
+    if (!term.sample && usecaseConfig?.sample) term.sample = usecaseConfig.sample;
+    return term;
+  }
+  validateOpts(opts) {
+    if (opts.callback == null) throw new Error("callback is required");
+    if (opts.app == null) throw new Error("app is required");
+    if (opts.holder == null) throw new Error("holder is required");
+    if (opts.usecase == null) throw new Error("usecase is required");
+    if (!opts.app.vocabApi.termdbConfig?.termType2terms)
+      throw new Error("termType2terms is required in termdbConfig for singleCellCellType handler");
+  }
+};
+
+export {
+  SearchHandler
+};
+//# sourceMappingURL=chunk-CD2WD7ZG.js.map

package/dist/chunk-CUHJN6CC.js

@@ -0,0 +1,217 @@
+import {
+  DATermTypes,
+  DMRCATE_DEFAULTS
+} from "./chunk-QI6X4V43.js";
+import {
+  dofetch3
+} from "./chunk-YU7CVG4B.js";
+import {
+  DMR_SCAN_ELEMENT_TYPE
+} from "./chunk-57Z4VYLM.js";
+import {
+  rgb
+} from "./chunk-Q5RDQNIT.js";
+
+// plots/volcano/colors.ts
+function getGroupColors(config) {
+  const groups = config?.samplelst?.groups;
+  const termValues = config?.tw?.term?.values;
+  const rawDown = termValues?.[groups?.[0]?.name]?.color || "red";
+  const rawUp = termValues?.[groups?.[1]?.name]?.color || "blue";
+  return {
+    controlColor: toHex(rawDown, "red"),
+    caseColor: toHex(rawUp, "blue")
+  };
+}
+function toHex(color, fallback) {
+  const c = rgb(color || fallback);
+  return c.displayable() ? c.formatHex() : rgb(fallback).formatHex();
+}
+
+// plots/volcano/model/VolcanoModel.ts
+var VolcanoModel = class {
+  /** TODO: This model is used in both the volcano and gsea.
+   * In the future, create base model in DA and use specific
+   * classes for the volcano and gsea. */
+  constructor(plot, termType) {
+    this.plot = plot;
+    this.app = plot.app;
+    this.termType = termType;
+  }
+  /** May use mapper instead as more termTypes are added */
+  async getData(config, settings) {
+    this.config = config;
+    this.settings = settings;
+    if (this.termType === DATermTypes.GENE_EXPRESSION) {
+      const body = await this.getGERequestBody();
+      const response = await dofetch3("termdb/DE", { body, signal: this.plot.api?.getAbortSignal() });
+      if (response && !response.error) response.daRequest = body;
+      return response;
+    }
+    if (this.termType === DATermTypes.DNA_METHYLATION) {
+      const body = await this.getDMRequestBody();
+      const response = await dofetch3("termdb/diffMeth", { body, signal: this.plot.api?.getAbortSignal() });
+      if (response && !response.error) response.daRequest = body;
+      return response;
+    }
+    if (this.termType === DATermTypes.SINGLECELL_CELLTYPE) {
+      const body = await this.getSCCTRequestBody();
+      return await dofetch3("termdb/singlecellDEgenes", { body, signal: this.plot.api?.getAbortSignal() });
+    }
+    if (this.termType === DATermTypes.PROTEOME_DAP) {
+      const body = this.getDapRequestBody();
+      return await dofetch3("termdb/dapVolcano", { body, signal: this.plot.api?.getAbortSignal() });
+    }
+    if (this.termType === DATermTypes.SINGLECELL_GENE_EXPRESSION) {
+    }
+    throw new Error(`Volcano plot does not support route for termType='${this.termType}'`);
+  }
+  //Gene expression
+  async getGERequestBody() {
+    await this.getOtherSamples(this.config.samplelst);
+    const state = this.app.getState();
+    const body = {
+      kind: "DE",
+      genome: this.app.vocabApi.vocab.genome,
+      dslabel: this.app.vocabApi.vocab.dslabel,
+      method: this.settings.method,
+      min_count: this.settings.minCount,
+      min_total_count: this.settings.minTotalCount,
+      samplelst: this.config.samplelst,
+      filter: state.termfilter.filter,
+      filter0: state.termfilter.filter0,
+      cpm_cutoff: this.settings.cpmCutoff,
+      volcanoRender: this.getVolcanoRender()
+    };
+    const pseudobulk = this.config.tw?.pseudobulk;
+    if (pseudobulk) body.pseudobulk = pseudobulk;
+    this.addConfounderTw(body);
+    return body;
+  }
+  //DNA methylation
+  async getDMRequestBody() {
+    await this.getOtherSamples(this.config.samplelst);
+    const state = this.app.getState();
+    const body = {
+      kind: "DM",
+      genome: this.app.vocabApi.vocab.genome,
+      dslabel: this.app.vocabApi.vocab.dslabel,
+      samplelst: this.config.samplelst,
+      filter: state.termfilter.filter,
+      filter0: state.termfilter.filter0,
+      min_samples_per_group: this.settings.minSamplesPerGroup,
+      exclude_sex_chr: this.settings.excludeSexChr,
+      /* Omitted rather than sent as 'promoter' when it is the default, so a request
+      from a promoter-only dataset is byte-identical to what this client sent before
+      the element picker existed. The server resolves an absent element_type to
+      'promoter'. This does NOT preserve cache keys -- the key object gained the
+      field server-side, so every pre-existing dm/ entry is orphaned on deploy
+      regardless of what the client sends. */
+      ...this.settings.elementType && this.settings.elementType != "promoter" ? { element_type: this.settings.elementType } : {},
+      // the scan's own knobs; the server ignores them for any other element type
+      ...this.settings.elementType == DMR_SCAN_ELEMENT_TYPE ? {
+        scan: {
+          ...this.settings.scanChromosome ? { chromosome: this.settings.scanChromosome } : {},
+          backgroundCorrection: !!this.settings.backgroundCorrection,
+          minCpgs: this.settings.minCpgs,
+          profileBinBp: this.settings.profileBinBp,
+          // only when changed: an explicit default would orphan every cached scan
+          ...this.settings.lambda != DMRCATE_DEFAULTS.lambda ? { lambda: this.settings.lambda } : {},
+          ...this.settings.C != DMRCATE_DEFAULTS.C ? { C: this.settings.C } : {},
+          ...this.settings.fdrCutoff != DMRCATE_DEFAULTS.fdrCutoff ? { fdrCutoff: this.settings.fdrCutoff } : {}
+        }
+      } : {},
+      volcanoRender: this.getVolcanoRender()
+    };
+    if (this.settings.elementType != DMR_SCAN_ELEMENT_TYPE) this.addConfounderTw(body);
+    return body;
+  }
+  /** Parameters telling the server to run the `volcano` Rust renderer and return a
+   * volcano PNG + top-significant rows instead of the full dot list. */
+  getVolcanoRender() {
+    const dotRadius = Math.max(this.settings.width, this.settings.height) / 80;
+    const { caseColor, controlColor } = getGroupColors(this.config);
+    const useDeltaBeta = this.termType === DATermTypes.DNA_METHYLATION && this.settings.xAxis == "delta_beta";
+    return {
+      significanceThresholds: {
+        pValueCutoff: this.settings.pValue,
+        pValueType: this.settings.pValueType,
+        foldChangeCutoff: useDeltaBeta ? this.settings.deltaBetaCutoff : this.settings.foldChangeCutoff
+      },
+      ...useDeltaBeta ? { xField: "delta_beta" } : {},
+      // Tied to the delta-beta axis: the control that sets it is only offered for
+      // methylation, and centering a log2 fold-change axis is a different conversation.
+      ...useDeltaBeta && this.settings.centerDeltaBeta ? { centerX: true } : {},
+      pixelWidth: this.settings.width,
+      pixelHeight: this.settings.height,
+      colorSignificant: toHex(this.settings.defaultSignColor, "red"),
+      colorSignificantUp: caseColor,
+      colorSignificantDown: controlColor,
+      colorNonsignificant: toHex(this.settings.defaultNonSignColor, "black"),
+      dotRadius,
+      maxInteractiveDots: this.settings.maxInteractiveDots,
+      // Render the PNG at device-pixel resolution so it stays sharp on
+      // retina screens. The server reports the plot extent in CSS-space,
+      // so SVG overlay coords are unaffected.
+      //
+      // Oversample by 2× so the PNG also stays sharp when the user
+      // *zooms in after* the initial render (the captured DPR is frozen
+      // at fetch time — bigger headroom = more tolerable post-render
+      // zoom before pixelation appears). The server clamp keeps the
+      // bitmap memory bounded.
+      devicePixelRatio: (typeof window !== "undefined" ? window.devicePixelRatio : 1) * 2
+    };
+  }
+  //This is a workaround until the server can accept an arr of confounder tws
+  addConfounderTw(body) {
+    const confounders = this.config?.confounderTws;
+    if (confounders?.length) {
+      body.tw = this.config.confounderTws[0];
+      if (confounders.length > 1) body.tw2 = this.config.confounderTws[1];
+    }
+  }
+  //Single cell cell type
+  getSCCTRequestBody() {
+    const body = {
+      genome: this.app.vocabApi.vocab.genome,
+      dslabel: this.app.vocabApi.vocab.dslabel,
+      sample: this.config.sample,
+      termId: this.config.termId,
+      categoryName: this.config.categoryName,
+      volcanoRender: this.getVolcanoRender()
+    };
+    return body;
+  }
+  getDapRequestBody() {
+    const { organism, assay, cohort } = this.config.proteomeDetails;
+    return {
+      genome: this.app.vocabApi.vocab.genome,
+      dslabel: this.app.vocabApi.vocab.dslabel,
+      organism,
+      assay,
+      cohort,
+      volcanoRender: this.getVolcanoRender()
+    };
+  }
+  /** retrieve the sampleId/sampleName for samples in
+   * the "others" group instead of using {in: false} */
+  async getOtherSamples(samplelst) {
+    const othersSamplesGroup = samplelst.groups.find((g) => !g.in);
+    if (!othersSamplesGroup) return;
+    const state = this.app.getState();
+    const samplesGroup = samplelst.groups.find((g) => g.in);
+    othersSamplesGroup.values = [];
+    for (const s of await this.plot.vocabApi.getFilteredSampleList(state.termfilter.filter)) {
+      if (!samplesGroup.values.some((i) => i.sampleId == s.id)) {
+        othersSamplesGroup.values.push({ sampleId: s.id, sample: s.name });
+      }
+    }
+    othersSamplesGroup.in = true;
+  }
+};
+
+export {
+  getGroupColors,
+  VolcanoModel
+};
+//# sourceMappingURL=chunk-CUHJN6CC.js.map