@sjcrh/proteinpaint-client 2.200.0 → 2.202.0

package/dist/DEinput-3HVHJE2I.js.map

@@ -0,0 +1,7 @@
+{
+  "version": 3,
+  "sources": ["../plots/DEinput.ts"],
+  "sourcesContent": ["import { PlotBase } from './PlotBase.ts'\nimport { getCompInit, copyMerge, type ComponentApi, type RxComponent } from '#rx'\nimport {\n\tfilterInit,\n\tfilterPromptInit,\n\tgetNormalRoot,\n\texcludeFilterByTag,\n\tfilterJoin,\n\tnegateFilter\n} from '#filter/filter'\nimport { getColors } from '#shared/common.js'\nimport { rgb } from 'd3-color'\nimport { make_radios, renderTable, Tabs } from '#dom'\nimport { dofetch3 } from '#common/dofetch'\nimport { renderPreAnalysisData } from '#mass/groups'\nimport { TermTypeGroups, termType2label } from '#shared/terms.js'\n\nconst colorScale = getColors(5)\n\nclass DEinputPlot extends PlotBase implements RxComponent {\n\tstatic type = 'DEinput'\n\n\t// expected RxComponent props, some are already declared/set in PlotBase\n\ttype: string\n\tparentId?: string\n\tdom!: {\n\t\t[index: string]: any\n\t}\n\tcomponents: {\n\t\t[name: string]: ComponentApi | { [name: string]: ComponentApi }\n\t} = {}\n\t// expected class-specific props\n\tconfig: any\n\tgroups: any[]\n\tfilterPrompt: any\n\texpressionSource?: 'bulk' | 'pseudobulk'\n\tpseudobulk?: { assay: string; memberId: string; category: string }\n\thasCohort0?: boolean\n\n\tconstructor(opts, api) {\n\t\tsuper(opts, api)\n\t\tthis.type = DEinputPlot.type\n\t\tthis.opts = opts\n\t\tthis.dom = this.getDom()\n\t\tthis.groups = []\n\t}\n\n\tgetDom() {\n\t\tconst header = this.opts?.header?.html('Differential Gene Expression') || undefined\n\t\tconst holder = this.opts.holder.append('div').style('margin', '10px')\n\t\tconst expressionSource = holder.append('div').style('margin-bottom', '15px')\n\t\tconst table = holder.append('div')\n\t\tconst btns = holder.append('div').style('margin-top', '5px')\n\t\tconst addGroup = btns.append('div').style('display', 'inline-block')\n\t\tconst submit = btns\n\t\t\t.append('div')\n\t\t\t.style('display', 'none')\n\t\t\t.style('margin-left', '15px')\n\t\t\t.attr('class', 'sja_new_filter_btn sja_menuoption')\n\t\tconst loading = holder.append('div').style('display', 'none').style('margin', '20px 10px').text('Loading...')\n\t\tconst preAnalysis = holder\n\t\t\t.append('div')\n\t\t\t.style('display', 'none')\n\t\t\t.style('margin-top', '20px')\n\t\t\t.style('margin-left', '5px')\n\t\tconst dom = { header, expressionSource, table, addGroup, submit, loading, preAnalysis }\n\t\treturn dom\n\t}\n\n\tgetState(appState) {\n\t\tconst config = appState.plots.find(p => p.id === this.id)\n\t\tif (!config) {\n\t\t\tthrow `No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`\n\t\t}\n\t\treturn {\n\t\t\ttermfilter: appState.termfilter,\n\t\t\tconfig,\n\t\t\t// quick fix to skip history tracking as needed\n\t\t\t_scope_: appState._scope_\n\t\t}\n\t}\n\n\tasync init() {\n\t\tawait this.renderExpressionSourceUI()\n\t}\n\n\t// TODO: handle errors\n\tasync main() {\n\t\tthis.dom.preAnalysis.selectAll('*').remove()\n\t\tif (!this.expressionSource || (this.expressionSource === 'pseudobulk' && !this.pseudobulk)) {\n\t\t\tthis.dom.table.style('display', 'none')\n\t\t\tthis.dom.addGroup.style('display', 'none')\n\t\t\tthis.dom.submit.style('display', 'none')\n\t\t\treturn\n\t\t}\n\t\tthis.dom.addGroup.style('display', 'inline-block')\n\t\tthis.makeGroupsUI()\n\t\tthis.hasCohort0 = this.groups.some(g => g.filter.lst.some(item => item.tvs?.term.type == 'cohort'))\n\t\tthis.mayRenderSubmit()\n\t}\n\n\tasync renderExpressionSourceUI() {\n\t\tconst config = this.app.vocabApi.termdbConfig\n\t\tconst hasBulk = !!config.queries?.rnaseqGeneCount\n\t\tconst terms = config.termType2terms?.[TermTypeGroups.PSEUDOBULK] || []\n\t\tconst hasPseudobulk = terms.length > 0\n\t\tif (!hasBulk && !hasPseudobulk)\n\t\t\tthrow new Error('No gene expression count data configured for differential analysis')\n\n\t\tif (hasBulk && !hasPseudobulk) {\n\t\t\tthis.expressionSource = 'bulk'\n\t\t\treturn\n\t\t}\n\n\t\tif (!hasBulk) {\n\t\t\tthis.expressionSource = 'pseudobulk'\n\t\t\tthis.renderPseudobulkSelection(this.dom.expressionSource, terms)\n\t\t\treturn\n\t\t}\n\n\t\tconst tabs = [\n\t\t\t{\n\t\t\t\tlabel: 'Bulk RNA-seq',\n\t\t\t\tactive: true,\n\t\t\t\tcallback: async () => {\n\t\t\t\t\tthis.expressionSource = 'bulk'\n\t\t\t\t\tawait this.main()\n\t\t\t\t}\n\t\t\t},\n\t\t\t{\n\t\t\t\tlabel: 'Single-cell pseudobulk',\n\t\t\t\tcallback: async (_event, tab) => {\n\t\t\t\t\tthis.expressionSource = 'pseudobulk'\n\t\t\t\t\ttab.contentHolder.selectAll('*').remove()\n\t\t\t\t\tthis.renderPseudobulkSelection(tab.contentHolder, terms)\n\t\t\t\t\tawait this.main()\n\t\t\t\t}\n\t\t\t}\n\t\t]\n\t\tawait new Tabs({ holder: this.dom.expressionSource, tabs }).main()\n\t}\n\n\trenderPseudobulkSelection(holder, terms) {\n\t\tconst assayMap = new Map<string, Map<string, any[]>>()\n\t\tfor (const term of terms) {\n\t\t\tif (!assayMap.has(term.assay)) assayMap.set(term.assay, new Map())\n\t\t\tconst memberMap = assayMap.get(term.assay)!\n\t\t\tif (!memberMap.has(term.memberId)) memberMap.set(term.memberId, [])\n\t\t\tmemberMap.get(term.memberId)!.push(term)\n\t\t}\n\n\t\tconst renderAssay = (assayHolder, assay, memberMap) => {\n\t\t\tassayHolder.selectAll('*').remove()\n\t\t\tconst renderMember = (memberHolder, memberId, memberTerms) => {\n\t\t\t\tmemberHolder.selectAll('*').remove()\n\t\t\t\tmemberHolder.append('div').style('opacity', 0.7).text(`Select from ${memberId}:`)\n\t\t\t\tmake_radios({\n\t\t\t\t\tholder: memberHolder,\n\t\t\t\t\tinputName: `sjpp-de-pseudobulk-${this.id}-${assay}-${memberId}`,\n\t\t\t\t\toptions: memberTerms.map(term => ({\n\t\t\t\t\t\tlabel: term.name,\n\t\t\t\t\t\tvalue: term.id,\n\t\t\t\t\t\tchecked:\n\t\t\t\t\t\t\tthis.pseudobulk?.assay === assay &&\n\t\t\t\t\t\t\tthis.pseudobulk?.memberId === memberId &&\n\t\t\t\t\t\t\tthis.pseudobulk?.category === (term.category || term.id),\n\t\t\t\t\t\ttestid: `sjpp-de-pseudobulk-category-${term.id}`\n\t\t\t\t\t})),\n\t\t\t\t\tstyles: { display: 'block', padding: '3px 5px' },\n\t\t\t\t\tcallback: async value => {\n\t\t\t\t\t\tconst term = memberTerms.find(term => term.id == value)\n\t\t\t\t\t\tthis.pseudobulk = { assay, memberId, category: term.category || term.id }\n\t\t\t\t\t\tawait this.main()\n\t\t\t\t\t}\n\t\t\t\t})\n\t\t\t}\n\n\t\t\tif (memberMap.size === 1) {\n\t\t\t\tconst [memberId, memberTerms] = memberMap.entries().next().value\n\t\t\t\trenderMember(assayHolder, memberId, memberTerms)\n\t\t\t} else {\n\t\t\t\tconst memberTabs = Array.from(memberMap, ([memberId, memberTerms]) => ({\n\t\t\t\t\tlabel: memberId,\n\t\t\t\t\tcallback: (_event, tab) => renderMember(tab.contentHolder, memberId, memberTerms)\n\t\t\t\t}))\n\t\t\t\tnew Tabs({ holder: assayHolder, tabs: memberTabs }).main()\n\t\t\t}\n\t\t}\n\n\t\tif (assayMap.size === 1) {\n\t\t\tconst [assay, memberMap] = Array.from(assayMap)[0]\n\t\t\tholder.append('div').text('Single-cell pseudobulk ' + termType2label(assay))\n\t\t\trenderAssay(holder.append('div'), assay, memberMap)\n\t\t} else {\n\t\t\tconst assayTabs = Array.from(assayMap, ([assay, memberMap]) => ({\n\t\t\t\tlabel: termType2label(assay),\n\t\t\t\tcallback: (_event, tab) => renderAssay(tab.contentHolder, assay, memberMap)\n\t\t\t}))\n\t\t\tnew Tabs({ holder, tabs: assayTabs, linePosition: 'right', tabsPosition: 'vertical' }).main()\n\t\t}\n\t}\n\n\tasync makeGroupsUI() {\n\t\t// filter prompt\n\t\tif (!this.filterPrompt) {\n\t\t\tthis.filterPrompt = await filterPromptInit({\n\t\t\t\tholder: this.dom.addGroup,\n\t\t\t\tvocabApi: this.app.vocabApi,\n\t\t\t\temptyLabel: 'Add group',\n\t\t\t\theader_mode: this.opts?.header_mode,\n\t\t\t\tcallback: async f => {\n\t\t\t\t\tconst filter = getNormalRoot(f)\n\t\t\t\t\tthis.addNewGroup(filter, this.groups)\n\t\t\t\t\tawait this.main()\n\t\t\t\t},\n\t\t\t\tdebug: this.opts.debug\n\t\t\t})\n\t\t}\n\n\t\t// filterPrompt.main() always empties the filterUiRoot data\n\t\tconst filter = structuredClone(this.state?.termfilter?.filter)\n\t\tthis.filterPrompt.main(excludeFilterByTag(filter, 'cohortFilter')) // provide mass filter to limit the term tree\n\n\t\tif (!this.groups.length) {\n\t\t\t// no groups, hide table\n\t\t\tthis.dom.table.style('display', 'none')\n\t\t\treturn\n\t\t}\n\n\t\t// clear table and populate rows\n\t\tthis.dom.table.style('display', 'block').selectAll('*').remove()\n\t\tconst tableArg: any = {\n\t\t\tdiv: this.dom.table,\n\t\t\tcolumns: [\n\t\t\t\t{}, // blank column to add delete buttons\n\t\t\t\t{\n\t\t\t\t\tlabel: 'NAME',\n\t\t\t\t\teditCallback: async (i, cell) => {\n\t\t\t\t\t\tconst newName = cell.value\n\t\t\t\t\t\tconst index = this.groups.findIndex(group => group.name == newName)\n\t\t\t\t\t\tif (index != -1) {\n\t\t\t\t\t\t\talert(`Group named ${newName} already exists`)\n\t\t\t\t\t\t\tawait this.main()\n\t\t\t\t\t\t} else {\n\t\t\t\t\t\t\tthis.groups[i].name = newName\n\t\t\t\t\t\t\tawait this.main()\n\t\t\t\t\t\t}\n\t\t\t\t\t}\n\t\t\t\t},\n\t\t\t\t{\n\t\t\t\t\tlabel: 'COLOR',\n\t\t\t\t\teditCallback: async (i, cell) => {\n\t\t\t\t\t\tthis.groups[i].color = cell.color\n\t\t\t\t\t\tthis.main()\n\t\t\t\t\t}\n\t\t\t\t},\n\t\t\t\t// dataset may rename what a row counts (GDC: cases, not samples)\n\t\t\t\t{ label: `#${(this.app.vocabApi.termdbConfig?.uiLabels?.Sample || 'Sample').toUpperCase()}` },\n\t\t\t\t{ label: 'FILTER' }\n\t\t\t],\n\t\t\trows: [],\n\t\t\tstriped: false, // no alternating row bg color so delete button appears more visible\n\t\t\tshowLines: false\n\t\t}\n\n\t\tfor (const g of this.groups) {\n\t\t\ttableArg.rows.push([\n\t\t\t\t{}, // blank cell to add delete button\n\t\t\t\t{ value: g.name }, // to allow click to show <input>\n\t\t\t\t{ color: g.color },\n\t\t\t\t{ value: '' }, // filled in asynchronously below, so one slow count does not hold up the table\n\t\t\t\t{} // blank cell to show filter ui\n\t\t\t])\n\t\t}\n\n\t\trenderTable(tableArg)\n\n\t\t// after rendering table, iterate over rows again to fill cells with control elements\n\t\tfor (const [i, row] of tableArg.rows.entries()) {\n\t\t\t// add delete button in 1st cell\n\t\t\trow[0].__td\n\t\t\t\t.append('div')\n\t\t\t\t.attr('class', 'sja_menuoption')\n\t\t\t\t.style('padding', '1px 6px')\n\t\t\t\t.html('&times;')\n\t\t\t\t.on('click', () => {\n\t\t\t\t\tthis.groups.splice(i, 1)\n\t\t\t\t\tthis.main()\n\t\t\t\t})\n\n\t\t\t// fill the #SAMPLE cell. not awaited: the table is already rendered, and on gdc each count\n\t\t\t// is a /cases round trip\n\t\t\tthis.app.vocabApi\n\t\t\t\t.getFilteredSampleCount(this.groups[i].filter, this.hasCohort0 ? null : this.state.termfilter.filter0)\n\t\t\t\t.then(n => row[3].__td.text(n))\n\t\t\t\t.catch(e => row[3].__td.text('n/a').attr('title', e?.message || e))\n\n\t\t\t// create filter ui in its cell\n\t\t\tconst group = this.groups[i]\n\t\t\tfilterInit({\n\t\t\t\tholder: row[4].__td,\n\t\t\t\tvocabApi: this.app.vocabApi,\n\t\t\t\theader_mode: 'hide_search',\n\t\t\t\tcallback: f => {\n\t\t\t\t\tif (!f || f.lst.length == 0) {\n\t\t\t\t\t\t// blank filter (user removed last tvs from this filter), delete this element from groups[]\n\t\t\t\t\t\tconst i = this.groups.findIndex(g => g.name == group.name)\n\t\t\t\t\t\tthis.groups.splice(i, 1)\n\t\t\t\t\t} else {\n\t\t\t\t\t\t// update filter\n\t\t\t\t\t\tgroup.filter = f\n\t\t\t\t\t}\n\t\t\t\t\tthis.main()\n\t\t\t\t}\n\t\t\t}).main(group.filter)\n\t\t}\n\n\t\tthis.dom.addGroup.select('.sja_new_filter_btn').style('pointer-events', 'auto').style('opacity', 1)\n\t}\n\n\taddNewGroup(filter, groups, name?: string) {\n\t\tif (!groups) throw 'groups is missing'\n\t\tif (!name) {\n\t\t\tconst base = 'New group'\n\t\t\tname = base\n\t\t\tfor (let i = 0; ; i++) {\n\t\t\t\tname = base + (i === 0 ? '' : ' ' + i)\n\t\t\t\tif (!groups.find(g => g.name === name)) break\n\t\t\t}\n\t\t}\n\t\tconst newGroup = {\n\t\t\tname,\n\t\t\tfilter,\n\t\t\tcolor: rgb(colorScale(groups.length)).formatHex()\n\t\t}\n\t\tgroups.push(newGroup)\n\t}\n\n\tmayRenderSubmit() {\n\t\tif (!this.groups.length || (this.groups.length == 1 && this.hasCohort0)) {\n\t\t\t// currently unable to negate filter0, so enforcing two-group\n\t\t\t// comparison when cohort0 is used\n\t\t\tthis.dom.submit.style('display', 'none')\n\t\t\treturn\n\t\t}\n\t\tthis.dom.submit.style('display', 'inline-block')\n\t\tif (this.groups.length == 1) {\n\t\t\t// single group of samples, compare with all other samples\n\t\t\tthis.dom.submit.text(`Submit (${this.groups[0].name} vs others)`)\n\t\t\tthis.dom.submit.on('click', async () => {\n\t\t\t\tconst groups = [this.groups[0]]\n\t\t\t\tconst otherGroup = {\n\t\t\t\t\tname: 'Not in ' + groups[0].name,\n\t\t\t\t\tcolor: '#ccc',\n\t\t\t\t\tfilter: negateFilter(groups[0].filter)\n\t\t\t\t}\n\t\t\t\tgroups.push(otherGroup)\n\t\t\t\tawait this.clickSubmit(groups)\n\t\t\t})\n\t\t} else if (this.groups.length == 2) {\n\t\t\t// two groups of samples, compare these groups\n\t\t\tthis.dom.addGroup.select('.sja_new_filter_btn').style('pointer-events', 'none').style('opacity', 0.5)\n\t\t\tthis.dom.submit.text(`Submit (${this.groups[0].name} vs ${this.groups[1].name})`)\n\t\t\tthis.dom.submit.on('click', async () => {\n\t\t\t\tawait this.clickSubmit(this.groups)\n\t\t\t})\n\t\t} else {\n\t\t\tthrow new Error('cannot exceed 2 groups')\n\t\t}\n\t}\n\n\tasync clickSubmit(groups) {\n\t\tthis.dom.loading.style('display', 'block')\n\t\tconst samplelstTW: any = {\n\t\t\tq: { groups: [] },\n\t\t\tterm: {\n\t\t\t\tname: groups.map(g => g.name).join(' vs '),\n\t\t\t\ttype: 'samplelst',\n\t\t\t\tvalues: {}\n\t\t\t}\n\t\t}\n\t\tif (this.expressionSource === 'pseudobulk') samplelstTW.pseudobulk = this.pseudobulk\n\t\t// ignore filter0 when cohort0 is used\n\t\tconst filter0 = this.hasCohort0 ? null : this.state.termfilter.filter0\n\t\tfor (const g of groups) {\n\t\t\tconst samples = await this.vocabApi!.getFilteredSampleList(\n\t\t\t\tfilterJoin([g.filter, this.state.termfilter.filter]),\n\t\t\t\tfilter0\n\t\t\t)\n\t\t\tconst sampleIds = samples.map(s => {\n\t\t\t\treturn { sampleId: s.id }\n\t\t\t})\n\t\t\tsamplelstTW.q.groups.push({\n\t\t\t\tname: g.name,\n\t\t\t\tin: true,\n\t\t\t\tvalues: sampleIds\n\t\t\t})\n\t\t\tsamplelstTW.term.values[g.name] = {\n\t\t\t\tcolor: g.color,\n\t\t\t\tkey: g.name,\n\t\t\t\tlabel: g.name\n\t\t\t}\n\t\t}\n\n\t\t// get actual numbers of samples with rnaseq count\n\t\tconst body: any = {\n\t\t\tgenome: this.app.vocabApi.vocab.genome,\n\t\t\tdslabel: this.app.vocabApi.vocab.dslabel,\n\t\t\tsamplelst: { groups: samplelstTW.q.groups },\n\t\t\tfilter: this.state.termfilter.filter,\n\t\t\tfilter0,\n\t\t\tpreAnalysis: true\n\t\t}\n\t\tif (this.expressionSource === 'pseudobulk') body.pseudobulk = this.pseudobulk\n\t\tconst preAnalysisData = await dofetch3('termdb/DE', { body })\n\n\t\tthis.dom.loading.style('display', 'none')\n\n\t\t// render sample counts. renderPreAnalysisData writes its own header, using the ds vocabulary\n\t\tthis.dom.preAnalysis.style('display', 'block').selectAll('*').remove()\n\n\t\trenderPreAnalysisData({\n\t\t\tpreAnalysisData,\n\t\t\tsamplelstTW,\n\t\t\tgroups: samplelstTW.q.groups,\n\t\t\tholder: this.dom.preAnalysis,\n\t\t\tself: this\n\t\t})\n\t}\n}\n\nexport const DEinputInit = getCompInit(DEinputPlot)\nexport const componentInit = DEinputInit\n\nexport async function getPlotConfig(opts) {\n\tconst config = {\n\t\tchartType: 'DEinput',\n\t\tsettings: {}\n\t}\n\n\t// may apply term-specific changes to the default object\n\treturn copyMerge(config, opts)\n}\n"],
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+  "names": ["term", "filter", "i"]
+}

package/dist/DifferentialAnalysis-NBC222Q6.js

@@ -0,0 +1,243 @@
+import {
+  getDefaultGseaSettings
+} from "./chunk-KTKZSYIH.js";
+import {
+  DATermTypes,
+  PlotBase,
+  Tabs,
+  enabledTermTypes,
+  getDefaultVolcanoSettings,
+  validateVolcanoSettings
+} from "./chunk-73PFJ2VF.js";
+import "./chunk-HJ6L54YS.js";
+import "./chunk-XFAL46LZ.js";
+import {
+  importPlot
+} from "./chunk-ZZMIDYRE.js";
+import {
+  Menu
+} from "./chunk-HYOEWQ5P.js";
+import "./chunk-6QCYT6G2.js";
+import "./chunk-FN5XPUPH.js";
+import "./chunk-VSSZJHOR.js";
+import "./chunk-5RUVBYLK.js";
+import "./chunk-ZFJUVP2N.js";
+import "./chunk-R3ARQMM4.js";
+import "./chunk-X4QQRHFB.js";
+import "./chunk-4WF3XDQP.js";
+import {
+  termType2label
+} from "./chunk-X6VTVZY7.js";
+import {
+  copyMerge,
+  getCompInit
+} from "./chunk-H6INPPUC.js";
+import "./chunk-PF4DSFDR.js";
+import "./chunk-L44P5N4U.js";
+import {
+  PROTEOME_DAP
+} from "./chunk-GEQUQ3GG.js";
+import "./chunk-WPHUM5S5.js";
+import "./chunk-75T7ESEO.js";
+import "./chunk-2KXLYFAO.js";
+import "./chunk-LOZEKOES.js";
+import "./chunk-VQZ2Z5YU.js";
+import "./chunk-UJELJXJG.js";
+import "./chunk-FXQXCOII.js";
+import "./chunk-TLT4YIG3.js";
+import "./chunk-5R63Q5KH.js";
+import "./chunk-I6Y4O3RR.js";
+import "./chunk-Q5RDQNIT.js";
+import "./chunk-DQC5FFGV.js";
+import "./chunk-HFNDKYVF.js";
+
+// plots/diffAnalysis/view/DiffAnalysisView.ts
+var DiffAnalysisView = class {
+  constructor(app, config, dom) {
+    this.app = app;
+    this.config = config;
+    this.dom = dom;
+    setRenderers(this);
+    this.tabsData = this.getTabsOptions(this);
+    this.tabs = new Tabs({ holder: this.dom.tabsDiv, tabs: this.tabsData });
+    this.tabs.main();
+  }
+  update(plotConfig) {
+    const activeTabIndex = this.tabsData.findIndex((tab) => tab.id == plotConfig.childType);
+    this.tabs.update(activeTabIndex);
+  }
+};
+function setRenderers(self) {
+  self.getTabsOptions = (self2) => {
+    const tabs = [
+      {
+        active: self2.config.childType === "volcano",
+        id: "volcano",
+        label: "Volcano",
+        isVisible: () => true,
+        // isVisible: () => self.config.termType === TermTypes.GENE_EXPRESSION,
+        getPlotConfig: () => {
+          return {
+            childType: "volcano"
+          };
+        },
+        callback: self2.tabCallback
+      },
+      {
+        active: self2.config.childType === "gsea",
+        id: "gsea",
+        label: "Gene Set Enrichment Analysis",
+        isVisible: () => self2.config.termType !== PROTEOME_DAP,
+        // isVisible: () => self.config.termType === TermTypes.GENE_EXPRESSION,
+        getPlotConfig: () => {
+          return {
+            childType: "gsea"
+          };
+        },
+        callback: self2.tabCallback
+      }
+    ];
+    return tabs;
+  };
+  self.tabCallback = async (event, tab) => {
+    if (!event || !tab || !tab.id) return;
+    const plotConfig = tab.getPlotConfig();
+    await self.app.dispatch({
+      type: "plot_edit",
+      id: self.config.id,
+      config: plotConfig
+    });
+  };
+}
+
+// plots/diffAnalysis/DifferentialAnalysis.ts
+var { SINGLECELL_CELLTYPE } = DATermTypes;
+var DifferentialAnalysis = class extends PlotBase {
+  constructor(opts, api) {
+    super(opts, api);
+    this.type = "differentialAnalysis";
+    this.components = {
+      plots: {}
+    };
+    this.termType = opts.termType;
+    const holder = opts.holder.classed("sjpp-diff-analysis-main", true);
+    const controls = opts.controls ? holder : holder.append("div");
+    const div = holder.append("div").style("padding", "5px").style("display", "inline-block").style("vertical-align", "top");
+    const tabsDiv = div.append("div").attr("id", "sjpp-diff-analysis-tabs").style("display", "inline-block");
+    const plots = div.append("div").attr("id", "sjpp-diff-analysis-tabs-content");
+    this.dom = {
+      controls: controls.style("display", "inline-block"),
+      div,
+      tabsDiv,
+      plots,
+      tip: new Menu({ padding: "" })
+    };
+    this.plotsControlsDiv = {};
+    this.plotsDiv = {};
+    if (opts.parentId) this.parentId = opts.parentId;
+    if (opts.header) {
+      this.dom.header = {
+        title: opts.header.append("span").style("margin-right", "5px").style("color", "darkslategray"),
+        plot: opts.header.append("span").style("font-size", "0.7em").style("opacity", 0.6)
+      };
+    }
+  }
+  static {
+    this.type = "differentialAnalysis";
+  }
+  getState(appState) {
+    const config = appState.plots.find((p) => p.id === this.id);
+    if (!config) {
+      throw new Error(
+        `No plot with id='${this.id}' found. Did you set this.id before this.api = getComponentApi(this)?`
+      );
+    }
+    return {
+      config
+    };
+  }
+  reactsTo(action) {
+    if (action.type.includes("cache_termq")) return true;
+    if (action.type.startsWith("plot_")) {
+      return action.id === this.id || action.id == this.parentId;
+    }
+    if (action.type.startsWith("filter")) return true;
+    if (action.type.startsWith("cohort")) return true;
+    if (action.type == "app_refresh") return true;
+  }
+  async init(appState) {
+    const state = this.getState(appState);
+    const config = structuredClone(state.config);
+    this.plotTabs = new DiffAnalysisView(this.app, config, this.dom);
+  }
+  async setComponent(config) {
+    this.plotsControlsDiv[config.childType] = this.dom.controls.append("div");
+    this.plotsDiv[config.childType] = this.dom.plots.append("div");
+    const opts = {
+      app: this.app,
+      holder: this.plotsDiv[config.childType],
+      id: this.id,
+      parent: this.api,
+      controls: this.plotsControlsDiv[config.childType],
+      termType: config.termType
+    };
+    const _ = await importPlot(config.childType, `unsupported childType='${config.childType}'`);
+    this.components.plots[config.childType] = await _.componentInit(opts);
+  }
+  async main() {
+    const config = structuredClone(this.state.config);
+    if (config.chartType != this.type) return;
+    if (!this.components.plots[config.childType]) await this.setComponent(config);
+    for (const childType in this.components.plots) {
+      const chart = this.components.plots[childType];
+      if (chart.type != config.childType) {
+        this.plotsDiv[chart.type].style("display", "none");
+        this.plotsControlsDiv[chart.type].style("display", "none");
+      }
+    }
+    this.plotsDiv[config.childType].style("display", "");
+    this.plotsControlsDiv[config.childType].style("display", "");
+    if (this.dom.header) {
+      if (config.tw) this.dom.header.title.text(config.tw.term.name);
+      if (config.headerText) this.dom.header.title.text(config.headerText);
+      const typeStr = termType2label(config.termType).toUpperCase();
+      this.dom.header.plot.text(` DIFFERENTIAL ${typeStr} ANALYSIS`);
+    }
+    if (this.plotTabs) this.plotTabs.update(config);
+  }
+};
+var DiffAnalysisInit = getCompInit(DifferentialAnalysis);
+var componentInit = DiffAnalysisInit;
+function getPlotConfig(opts) {
+  if (!opts.termType) throw new Error(".termType is required");
+  if (!enabledTermTypes.has(opts.termType))
+    throw new Error(`termType = '${opts.termType}' not supported by Differential Analysis`);
+  const config = {
+    chartType: "differentialAnalysis",
+    childType: "volcano",
+    termType: opts.termType,
+    settings: {},
+    highlightedData: opts.highlightedData || [],
+    hidePlotFilter: true
+    //TODO: Support filtering and reactivity in child plots
+  };
+  if (opts?.tw?.term?.name && opts.headerText)
+    throw new Error("Cannot provide both tw.term.name and headerText. Please choose one to use as the plot title.");
+  if (opts.termType == SINGLECELL_CELLTYPE) {
+    Object.assign(config, {
+      categoryName: opts.categoryName || "",
+      termId: opts.termId || "",
+      sample: opts.sample || { sID: "", eID: "" }
+    });
+  }
+  config.settings.volcano = getDefaultVolcanoSettings(opts.overrides, opts);
+  config.settings.gsea = getDefaultGseaSettings(opts.overrides, opts);
+  validateVolcanoSettings(config, opts);
+  return copyMerge(config, opts);
+}
+export {
+  DiffAnalysisInit,
+  componentInit,
+  getPlotConfig
+};
+//# sourceMappingURL=DifferentialAnalysis-NBC222Q6.js.map